DNAJC19P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.51421948
2ATP synthesis coupled proton transport (GO:0015986)7.27907249
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.27907249
4viral transcription (GO:0019083)7.15552998
5translational termination (GO:0006415)6.93943668
6ribosomal small subunit assembly (GO:0000028)6.58334194
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.54352580
8cotranslational protein targeting to membrane (GO:0006613)6.46306029
9ribosomal small subunit biogenesis (GO:0042274)6.44845138
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.39386689
11protein targeting to ER (GO:0045047)6.38325741
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.13639532
13protein localization to endoplasmic reticulum (GO:0070972)6.03776911
14maturation of SSU-rRNA (GO:0030490)5.93348052
15respiratory electron transport chain (GO:0022904)5.92489743
16electron transport chain (GO:0022900)5.84592008
17protein neddylation (GO:0045116)5.76311419
18chaperone-mediated protein transport (GO:0072321)5.74204751
19translational elongation (GO:0006414)5.68403589
20establishment of protein localization to mitochondrial membrane (GO:0090151)5.57233002
21ribosomal large subunit biogenesis (GO:0042273)5.38460263
22cellular protein complex disassembly (GO:0043624)5.24860325
23viral life cycle (GO:0019058)5.11639206
24proteasome assembly (GO:0043248)5.09813791
25translational initiation (GO:0006413)5.08492760
26protein complex biogenesis (GO:0070271)4.97943580
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.92760516
28NADH dehydrogenase complex assembly (GO:0010257)4.92760516
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.92760516
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.89860117
31mitochondrial respiratory chain complex assembly (GO:0033108)4.81332513
32translation (GO:0006412)4.81318404
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.47277463
34oxidative phosphorylation (GO:0006119)4.41713671
35protein complex disassembly (GO:0043241)4.39232331
36macromolecular complex disassembly (GO:0032984)4.28104406
37protein targeting to membrane (GO:0006612)4.23873013
38ATP biosynthetic process (GO:0006754)4.13623791
39termination of RNA polymerase III transcription (GO:0006386)4.08902305
40transcription elongation from RNA polymerase III promoter (GO:0006385)4.08902305
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.02830223
42regulation of mitochondrial translation (GO:0070129)4.02204652
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.95001184
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.95001184
45hydrogen ion transmembrane transport (GO:1902600)3.82116548
46cellular component biogenesis (GO:0044085)3.81441435
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.78255015
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.78074572
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.70837049
50pyrimidine nucleotide catabolic process (GO:0006244)3.70146179
51ribonucleoprotein complex biogenesis (GO:0022613)3.65936752
52protein targeting to mitochondrion (GO:0006626)3.61773151
53mRNA catabolic process (GO:0006402)3.48731076
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48630455
55regulation of cellular respiration (GO:0043457)3.48167419
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46796707
57proton transport (GO:0015992)3.41295840
58hydrogen transport (GO:0006818)3.37743407
59spliceosomal snRNP assembly (GO:0000387)3.33756292
60deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.33107250
61spliceosomal complex assembly (GO:0000245)3.32965783
62ribonucleoside triphosphate biosynthetic process (GO:0009201)3.32557682
63establishment of protein localization to mitochondrion (GO:0072655)3.28215960
64protein localization to mitochondrion (GO:0070585)3.25620561
65regulation of cilium movement (GO:0003352)3.22595325
66respiratory chain complex IV assembly (GO:0008535)3.22280579
67RNA catabolic process (GO:0006401)3.19654005
68DNA deamination (GO:0045006)3.18286947
69organelle disassembly (GO:1903008)3.17836701
70nucleoside triphosphate biosynthetic process (GO:0009142)3.10430650
71rRNA processing (GO:0006364)3.09862152
72deoxyribonucleotide catabolic process (GO:0009264)3.08137769
73deoxyribose phosphate catabolic process (GO:0046386)3.06337930
74protein targeting (GO:0006605)3.03391833
75mitochondrial transport (GO:0006839)3.01754116
76water-soluble vitamin biosynthetic process (GO:0042364)3.00625255
77purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.96976400
78purine nucleoside monophosphate biosynthetic process (GO:0009127)2.96976400
79deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96901832
80rRNA metabolic process (GO:0016072)2.96705132
81chromatin remodeling at centromere (GO:0031055)2.96622907
82negative regulation of heart rate (GO:0010459)2.93214650
83negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.92496387
84cullin deneddylation (GO:0010388)2.90869256
85establishment of protein localization to membrane (GO:0090150)2.89031056
86cytochrome complex assembly (GO:0017004)2.88973911
87regulation of oxidative phosphorylation (GO:0002082)2.86792886
88response to redox state (GO:0051775)2.86224128
89peptidyl-histidine modification (GO:0018202)2.85172022
90histone mRNA metabolic process (GO:0008334)2.84945852
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84664412
92ribonucleoprotein complex disassembly (GO:0032988)2.82328588
93DNA replication checkpoint (GO:0000076)2.79524357
94establishment of protein localization to organelle (GO:0072594)2.77019162
95rRNA modification (GO:0000154)2.76938091
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76202067
97negative regulation of appetite (GO:0032099)2.75849322
98negative regulation of response to food (GO:0032096)2.75849322
99CENP-A containing nucleosome assembly (GO:0034080)2.68588473
100formation of translation preinitiation complex (GO:0001731)2.67106805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.11282697
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.97876567
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.81769074
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.95401310
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35586059
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.33443296
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.19239263
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.19107978
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14797261
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.00837649
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.95604670
12ELK1_19687146_ChIP-ChIP_HELA_Human2.86069829
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82257425
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68713938
15VDR_22108803_ChIP-Seq_LS180_Human2.68292855
16VDR_23849224_ChIP-Seq_CD4+_Human2.67663577
17FOXP3_21729870_ChIP-Seq_TREG_Human2.21201993
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20510024
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04540208
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.03186975
21TTF2_22483619_ChIP-Seq_HELA_Human2.00560407
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88954552
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85124532
24MYC_18940864_ChIP-ChIP_HL60_Human1.82775994
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80984588
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80218973
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.79871427
28POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78324106
29DCP1A_22483619_ChIP-Seq_HELA_Human1.78035274
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75562306
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73699180
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73508337
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62427479
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60970748
35XRN2_22483619_ChIP-Seq_HELA_Human1.57828830
36GABP_19822575_ChIP-Seq_HepG2_Human1.55893976
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.54494416
38FUS_26573619_Chip-Seq_HEK293_Human1.54402230
39EWS_26573619_Chip-Seq_HEK293_Human1.49909529
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48972381
41IRF1_19129219_ChIP-ChIP_H3396_Human1.48153580
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47973876
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47682528
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47491362
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47197356
46ZNF274_21170338_ChIP-Seq_K562_Hela1.46502328
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38510629
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35119191
49TP53_22573176_ChIP-Seq_HFKS_Human1.34764815
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.28027484
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27858783
52EZH2_22144423_ChIP-Seq_EOC_Human1.22787184
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22249924
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21364998
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20748278
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19879209
57ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17010225
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15704233
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14573691
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13972060
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.13521925
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09167512
63AR_20517297_ChIP-Seq_VCAP_Human1.06711893
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06212276
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04546121
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04416610
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01665112
68TAF15_26573619_Chip-Seq_HEK293_Human1.00544931
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98258406
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98004647
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96832232
72P300_19829295_ChIP-Seq_ESCs_Human0.96638132
73PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95408184
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94953554
75NCOR_22424771_ChIP-Seq_293T_Human0.93976527
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93812727
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93648120
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93396271
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.91457266
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90750552
81GATA3_21878914_ChIP-Seq_MCF-7_Human0.90663492
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90417604
83E2F1_21310950_ChIP-Seq_MCF-7_Human0.89603468
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88783576
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88547375
86HTT_18923047_ChIP-ChIP_STHdh_Human0.88539247
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88331218
88KDM5A_27292631_Chip-Seq_BREAST_Human0.88156045
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.86903500
90SOX2_19829295_ChIP-Seq_ESCs_Human0.86715295
91NANOG_19829295_ChIP-Seq_ESCs_Human0.86715295
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86666861
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85528803
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83885110
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.83610832
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82115675
97CBP_20019798_ChIP-Seq_JUKART_Human0.82115675
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81720145
99RNF2_27304074_Chip-Seq_NSC_Mouse0.81351698
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80742936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.68422491
2MP0006292_abnormal_olfactory_placode4.12644995
3MP0003806_abnormal_nucleotide_metabolis3.33139135
4MP0002163_abnormal_gland_morphology3.21648630
5MP0005646_abnormal_pituitary_gland2.58806443
6MP0003186_abnormal_redox_activity2.50175400
7MP0002837_dystrophic_cardiac_calcinosis2.49598486
8MP0001529_abnormal_vocalization2.44221814
9MP0003880_abnormal_central_pattern2.40253851
10MP0005379_endocrine/exocrine_gland_phen2.25415446
11MP0004142_abnormal_muscle_tone2.19912816
12MP0002876_abnormal_thyroid_physiology2.16425098
13MP0008789_abnormal_olfactory_epithelium2.16297469
14MP0006072_abnormal_retinal_apoptosis2.15691881
15MP0001188_hyperpigmentation1.94365155
16MP0003123_paternal_imprinting1.93296453
17MP0004145_abnormal_muscle_electrophysio1.89048323
18MP0004147_increased_porphyrin_level1.74899481
19MP0006276_abnormal_autonomic_nervous1.73870756
20MP0003787_abnormal_imprinting1.72793814
21MP0001905_abnormal_dopamine_level1.71309679
22MP0008877_abnormal_DNA_methylation1.68240185
23MP0006036_abnormal_mitochondrial_physio1.65210656
24MP0002160_abnormal_reproductive_system1.63248176
25MP0003011_delayed_dark_adaptation1.62883724
26MP0003195_calcinosis1.60534125
27MP0005084_abnormal_gallbladder_morpholo1.59263609
28MP0005499_abnormal_olfactory_system1.57616641
29MP0005394_taste/olfaction_phenotype1.57616641
30MP0005389_reproductive_system_phenotype1.55831345
31MP0003567_abnormal_fetal_cardiomyocyte1.48450989
32MP0003786_premature_aging1.44962477
33MP0003646_muscle_fatigue1.41816368
34MP0000516_abnormal_urinary_system1.40268157
35MP0005367_renal/urinary_system_phenotyp1.40268157
36MP0000049_abnormal_middle_ear1.35471530
37MP0009697_abnormal_copulation1.34062935
38MP0000631_abnormal_neuroendocrine_gland1.33998195
39MP0002638_abnormal_pupillary_reflex1.32772109
40MP0002138_abnormal_hepatobiliary_system1.30537546
41MP0003121_genomic_imprinting1.29341444
42MP0001984_abnormal_olfaction1.29234214
43MP0005551_abnormal_eye_electrophysiolog1.25026338
44MP0010386_abnormal_urinary_bladder1.22987927
45MP0005636_abnormal_mineral_homeostasis1.22146302
46MP0001485_abnormal_pinna_reflex1.20980343
47MP0001293_anophthalmia1.18676186
48MP0003137_abnormal_impulse_conducting1.17350812
49MP0006035_abnormal_mitochondrial_morpho1.16643870
50MP0008875_abnormal_xenobiotic_pharmacok1.16449518
51MP0002938_white_spotting1.13358594
52MP0005670_abnormal_white_adipose1.13015749
53MP0001986_abnormal_taste_sensitivity1.12035902
54MP0003693_abnormal_embryo_hatching1.09479031
55MP0005645_abnormal_hypothalamus_physiol1.08466344
56MP0001919_abnormal_reproductive_system1.08214199
57MP0002272_abnormal_nervous_system1.08151816
58MP0009046_muscle_twitch1.06523261
59MP0001968_abnormal_touch/_nociception1.01771850
60MP0000372_irregular_coat_pigmentation1.00982513
61MP0003122_maternal_imprinting1.00810901
62MP0004957_abnormal_blastocyst_morpholog1.00683845
63MP0008872_abnormal_physiological_respon0.99580529
64MP0000566_synostosis0.97204863
65MP0002095_abnormal_skin_pigmentation0.94805636
66MP0002277_abnormal_respiratory_mucosa0.93959129
67MP0002736_abnormal_nociception_after0.93811093
68MP0009745_abnormal_behavioral_response0.93374047
69MP0005075_abnormal_melanosome_morpholog0.91339312
70MP0001727_abnormal_embryo_implantation0.90244396
71MP0002210_abnormal_sex_determination0.90089716
72MP0008995_early_reproductive_senescence0.89291153
73MP0001756_abnormal_urination0.85829664
74MP0005408_hypopigmentation0.85474172
75MP0002928_abnormal_bile_duct0.85418794
76MP0008058_abnormal_DNA_repair0.85154003
77MP0002102_abnormal_ear_morphology0.84008314
78MP0005332_abnormal_amino_acid0.83711457
79MP0003718_maternal_effect0.82102627
80MP0003938_abnormal_ear_development0.80335808
81MP0005410_abnormal_fertilization0.80249290
82MP0009780_abnormal_chondrocyte_physiolo0.79389309
83MP0000230_abnormal_systemic_arterial0.78132864
84MP0001970_abnormal_pain_threshold0.77637853
85MP0001440_abnormal_grooming_behavior0.76509107
86MP0001145_abnormal_male_reproductive0.75632042
87MP0001286_abnormal_eye_development0.74312295
88MP0000653_abnormal_sex_gland0.72984217
89MP0001765_abnormal_ion_homeostasis0.72304498
90MP0003315_abnormal_perineum_morphology0.72002840
91MP0005195_abnormal_posterior_eye0.70949480
92MP0005423_abnormal_somatic_nervous0.69364381
93MP0002733_abnormal_thermal_nociception0.66627376
94MP0003638_abnormal_response/metabolism_0.66233902
95MP0005253_abnormal_eye_physiology0.65972563
96MP0003890_abnormal_embryonic-extraembry0.64082041
97MP0001324_abnormal_eye_pigmentation0.63763190
98MP0002557_abnormal_social/conspecific_i0.63290567
99MP0000427_abnormal_hair_cycle0.63113015
100MP0001764_abnormal_homeostasis0.62931188

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.15094533
23-Methylglutaconic aciduria (HP:0003535)5.98459546
3Abnormal mitochondria in muscle tissue (HP:0008316)5.55618394
4Mitochondrial inheritance (HP:0001427)5.26643076
5Acute encephalopathy (HP:0006846)5.23326210
6Progressive macrocephaly (HP:0004481)5.14342759
7Increased CSF lactate (HP:0002490)4.72600791
8Hepatocellular necrosis (HP:0001404)4.39262614
9Increased hepatocellular lipid droplets (HP:0006565)4.21682820
10Lipid accumulation in hepatocytes (HP:0006561)4.20217952
11Hepatic necrosis (HP:0002605)4.14418679
12Cerebral edema (HP:0002181)4.07685630
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.02941808
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.02941808
15Macrocytic anemia (HP:0001972)3.99184063
16Abnormality of cells of the erythroid lineage (HP:0012130)3.76707787
17Congenital, generalized hypertrichosis (HP:0004540)3.69205966
18Renal Fanconi syndrome (HP:0001994)3.49885017
19Abnormal number of erythroid precursors (HP:0012131)3.29516193
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24564873
21Abnormality of alanine metabolism (HP:0010916)3.24564873
22Hyperalaninemia (HP:0003348)3.24564873
23Increased serum lactate (HP:0002151)3.16425440
24Aplastic anemia (HP:0001915)3.15984593
25Methylmalonic acidemia (HP:0002912)3.10857307
26Reticulocytopenia (HP:0001896)3.10645339
27Lactic acidosis (HP:0003128)3.10491400
28Exertional dyspnea (HP:0002875)3.07017523
29Increased serum pyruvate (HP:0003542)3.04351194
30Respiratory failure (HP:0002878)2.91637867
31Leukodystrophy (HP:0002415)2.90672879
32Increased intramyocellular lipid droplets (HP:0012240)2.86415315
33Optic disc pallor (HP:0000543)2.77674035
34Respiratory difficulties (HP:0002880)2.77592772
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.74588193
36Increased muscle lipid content (HP:0009058)2.60363680
37Exercise intolerance (HP:0003546)2.59191314
38Pallor (HP:0000980)2.54452569
39Medial flaring of the eyebrow (HP:0010747)2.53935814
40Abnormality of renal resorption (HP:0011038)2.52493674
41Colon cancer (HP:0003003)2.48413135
42Lethargy (HP:0001254)2.48085124
43Molar tooth sign on MRI (HP:0002419)2.47588094
44Abnormality of midbrain morphology (HP:0002418)2.47588094
45Stenosis of the external auditory canal (HP:0000402)2.41284861
46Methylmalonic aciduria (HP:0012120)2.38817466
47Pancreatic cysts (HP:0001737)2.37269001
48Glycosuria (HP:0003076)2.25752694
49Abnormality of urine glucose concentration (HP:0011016)2.25752694
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24975456
51Congenital primary aphakia (HP:0007707)2.21215898
52Abnormality of serum amino acid levels (HP:0003112)2.20549184
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18736201
54Gait imbalance (HP:0002141)2.18531621
55Abnormality of glycolysis (HP:0004366)2.15393021
56Generalized aminoaciduria (HP:0002909)2.14443715
57Thyroid-stimulating hormone excess (HP:0002925)2.06821619
58Testicular atrophy (HP:0000029)2.06794284
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06445114
60Microvesicular hepatic steatosis (HP:0001414)2.02364273
61CNS demyelination (HP:0007305)2.01358891
62Abnormality of magnesium homeostasis (HP:0004921)2.00828526
63X-linked dominant inheritance (HP:0001423)2.00182155
64Microretrognathia (HP:0000308)1.97644018
65Hyperphosphaturia (HP:0003109)1.96784221
66Hyperglycinemia (HP:0002154)1.95664626
67Nephrogenic diabetes insipidus (HP:0009806)1.94942676
68Dicarboxylic aciduria (HP:0003215)1.94053409
69Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94053409
70Triphalangeal thumb (HP:0001199)1.93736200
71Degeneration of anterior horn cells (HP:0002398)1.90652861
72Abnormality of the anterior horn cell (HP:0006802)1.90652861
73Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87949733
74Woolly hair (HP:0002224)1.87627742
75Type I transferrin isoform profile (HP:0003642)1.87626955
76Abnormal rod and cone electroretinograms (HP:0008323)1.86381439
77Delayed CNS myelination (HP:0002188)1.85844025
78Hypothermia (HP:0002045)1.81713816
79Aplasia/hypoplasia of the uterus (HP:0008684)1.81020413
80Type 2 muscle fiber atrophy (HP:0003554)1.78526037
81Megaloblastic anemia (HP:0001889)1.78331575
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78238024
83Abnormality of vitamin B metabolism (HP:0004340)1.78032808
84Pancreatic fibrosis (HP:0100732)1.77839834
85Hypoplasia of the radius (HP:0002984)1.75844241
86Parakeratosis (HP:0001036)1.75040415
87Nephronophthisis (HP:0000090)1.73663016
88Abnormal hemoglobin (HP:0011902)1.72735873
89Symphalangism affecting the phalanges of the hand (HP:0009773)1.72722499
90Congenital stationary night blindness (HP:0007642)1.72482385
91Abolished electroretinogram (ERG) (HP:0000550)1.71433771
92Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.70552495
93Abnormality of the vitamin B12 metabolism (HP:0004341)1.70239854
94Vomiting (HP:0002013)1.65581373
95Hypomagnesemia (HP:0002917)1.64885006
96Abnormality of the phalanges of the 5th finger (HP:0004213)1.63316538
97Cleft eyelid (HP:0000625)1.61028141
98Genital tract atresia (HP:0001827)1.59801578
99Rectovaginal fistula (HP:0000143)1.58218802
100Rectal fistula (HP:0100590)1.58218802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.26086360
2MAP3K122.77438795
3VRK22.76640845
4BUB12.68431505
5BCKDK2.61902375
6STK162.56313616
7ZAK2.28174459
8TLK12.04186597
9ARAF1.88732067
10TNIK1.88556455
11CDK191.85607965
12MAP4K21.85315319
13PLK41.84727913
14NEK11.80139964
15ILK1.76914092
16BMPR1B1.75395165
17MYLK1.73325556
18GRK11.72046121
19PDK21.70993849
20LIMK11.61253667
21ADRBK21.55107030
22EIF2AK31.53547750
23DYRK21.42759348
24NUAK11.35797741
25CDC71.35328347
26RPS6KA41.33540751
27PHKG21.33122380
28PHKG11.33122380
29WNK41.29525717
30PIM21.28704192
31WNK31.27975862
32MST41.27872049
33CSNK1G31.24127255
34VRK11.21479632
35SRPK11.21120647
36CSNK1G11.20338358
37MAP2K71.16702897
38TRIM281.12324073
39FRK1.08980090
40CSNK1G21.07254828
41EIF2AK11.06209128
42PIK3CA1.00710130
43CHEK20.99437979
44CDK80.98665170
45ABL20.91725384
46MAP3K90.89147644
47OXSR10.87333753
48CDK30.84785304
49TIE10.83009015
50AURKB0.82241468
51ACVR1B0.80527853
52OBSCN0.79720588
53DAPK30.79309840
54TNK20.78830173
55CSNK1A1L0.78074953
56INSRR0.77522071
57CSNK2A20.77278160
58IKBKB0.76415571
59RPS6KA50.72943123
60CSNK1A10.72349829
61PLK30.72311789
62BMPR20.71908954
63BRAF0.71553148
64PLK10.70979163
65DAPK10.70197423
66TEC0.70168037
67PINK10.68657253
68CSNK2A10.68183223
69TESK20.67801786
70DMPK0.67129703
71ATR0.64615651
72PRKCQ0.61880951
73KDR0.60664633
74CAMK10.59885517
75TGFBR10.57811588
76ADRBK10.56763388
77TXK0.55900810
78EIF2AK20.54551681
79PASK0.54414942
80AURKA0.54079176
81CAMKK20.53924464
82STK390.53899490
83CCNB10.52949104
84MKNK10.52705635
85MAP3K40.51925099
86PRKACA0.51360016
87PRKG10.51143550
88PRKCG0.50085864
89PLK20.49439177
90PAK10.48721177
91ERBB30.43720065
92CAMK2A0.43455466
93NEK20.42589506
94BRSK20.42411356
95NME10.41560227
96PIK3CG0.41043886
97KIT0.39515978
98CASK0.38820520
99LYN0.38543790
100CSNK1E0.38470092

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.04182185
2Oxidative phosphorylation_Homo sapiens_hsa001905.20695029
3Parkinsons disease_Homo sapiens_hsa050124.40003844
4Protein export_Homo sapiens_hsa030603.75727182
5Proteasome_Homo sapiens_hsa030503.36190549
6Huntingtons disease_Homo sapiens_hsa050163.06620142
7Alzheimers disease_Homo sapiens_hsa050103.04919138
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71180471
9RNA polymerase_Homo sapiens_hsa030202.50776153
10Cardiac muscle contraction_Homo sapiens_hsa042602.41614917
11Mismatch repair_Homo sapiens_hsa034302.07415029
12Asthma_Homo sapiens_hsa053102.04642118
13Homologous recombination_Homo sapiens_hsa034401.91091699
14DNA replication_Homo sapiens_hsa030301.80297827
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50899011
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50191641
17One carbon pool by folate_Homo sapiens_hsa006701.49033867
18Spliceosome_Homo sapiens_hsa030401.48556979
19Pyrimidine metabolism_Homo sapiens_hsa002401.46848431
20Nucleotide excision repair_Homo sapiens_hsa034201.41220493
21Propanoate metabolism_Homo sapiens_hsa006401.32810400
22RNA degradation_Homo sapiens_hsa030181.32041003
23Fanconi anemia pathway_Homo sapiens_hsa034601.31629430
24Basal transcription factors_Homo sapiens_hsa030221.22088143
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20295931
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.18370017
27Purine metabolism_Homo sapiens_hsa002301.16449342
28Base excision repair_Homo sapiens_hsa034101.15116978
29Folate biosynthesis_Homo sapiens_hsa007901.13712490
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03948088
31Regulation of autophagy_Homo sapiens_hsa041401.02300425
32Fatty acid elongation_Homo sapiens_hsa000621.01139396
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00769972
34Type I diabetes mellitus_Homo sapiens_hsa049400.99583760
35RNA transport_Homo sapiens_hsa030130.99364815
36Allograft rejection_Homo sapiens_hsa053300.97387628
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95113632
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94258010
39Linoleic acid metabolism_Homo sapiens_hsa005910.91539730
40Maturity onset diabetes of the young_Homo sapiens_hsa049500.91445240
41Autoimmune thyroid disease_Homo sapiens_hsa053200.90708115
42Caffeine metabolism_Homo sapiens_hsa002320.83052141
43Sulfur metabolism_Homo sapiens_hsa009200.79934026
44Phototransduction_Homo sapiens_hsa047440.78613736
45Graft-versus-host disease_Homo sapiens_hsa053320.77430666
46Metabolic pathways_Homo sapiens_hsa011000.72647543
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.72465872
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70934584
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.68293030
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67909681
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67024953
52Butanoate metabolism_Homo sapiens_hsa006500.66666669
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63884826
54Collecting duct acid secretion_Homo sapiens_hsa049660.63446157
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59323330
56Tryptophan metabolism_Homo sapiens_hsa003800.57735467
57Peroxisome_Homo sapiens_hsa041460.57455385
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55162724
59Glutathione metabolism_Homo sapiens_hsa004800.54154263
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53783885
61Pyruvate metabolism_Homo sapiens_hsa006200.52535572
62Chemical carcinogenesis_Homo sapiens_hsa052040.51872555
63Nicotine addiction_Homo sapiens_hsa050330.50933747
64Arachidonic acid metabolism_Homo sapiens_hsa005900.50554974
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48361059
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47920040
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47753503
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46668712
69Rheumatoid arthritis_Homo sapiens_hsa053230.46289786
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45185236
71Systemic lupus erythematosus_Homo sapiens_hsa053220.41230971
72beta-Alanine metabolism_Homo sapiens_hsa004100.39397470
73Sulfur relay system_Homo sapiens_hsa041220.39387365
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37354402
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37148512
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36721737
77Olfactory transduction_Homo sapiens_hsa047400.33650327
78Steroid biosynthesis_Homo sapiens_hsa001000.33043587
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.32063679
80Tyrosine metabolism_Homo sapiens_hsa003500.30275748
81Viral myocarditis_Homo sapiens_hsa054160.30196937
82Morphine addiction_Homo sapiens_hsa050320.29141643
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28459812
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27674943
85Retinol metabolism_Homo sapiens_hsa008300.26509279
86Fatty acid degradation_Homo sapiens_hsa000710.26428876
87Fat digestion and absorption_Homo sapiens_hsa049750.25799812
88Non-homologous end-joining_Homo sapiens_hsa034500.24393646
89Ether lipid metabolism_Homo sapiens_hsa005650.21636635
90Phenylalanine metabolism_Homo sapiens_hsa003600.20016729
91Serotonergic synapse_Homo sapiens_hsa047260.19943243
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18701538
93Cell cycle_Homo sapiens_hsa041100.17414039
94Mineral absorption_Homo sapiens_hsa049780.16322176
95GABAergic synapse_Homo sapiens_hsa047270.14950182
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14569542
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14350748
98p53 signaling pathway_Homo sapiens_hsa041150.14053832
99Epstein-Barr virus infection_Homo sapiens_hsa051690.13870972
100Antigen processing and presentation_Homo sapiens_hsa046120.07346347

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