Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.51421948 |
2 | ATP synthesis coupled proton transport (GO:0015986) | 7.27907249 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 7.27907249 |
4 | viral transcription (GO:0019083) | 7.15552998 |
5 | translational termination (GO:0006415) | 6.93943668 |
6 | ribosomal small subunit assembly (GO:0000028) | 6.58334194 |
7 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 6.54352580 |
8 | cotranslational protein targeting to membrane (GO:0006613) | 6.46306029 |
9 | ribosomal small subunit biogenesis (GO:0042274) | 6.44845138 |
10 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 6.39386689 |
11 | protein targeting to ER (GO:0045047) | 6.38325741 |
12 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 6.13639532 |
13 | protein localization to endoplasmic reticulum (GO:0070972) | 6.03776911 |
14 | maturation of SSU-rRNA (GO:0030490) | 5.93348052 |
15 | respiratory electron transport chain (GO:0022904) | 5.92489743 |
16 | electron transport chain (GO:0022900) | 5.84592008 |
17 | protein neddylation (GO:0045116) | 5.76311419 |
18 | chaperone-mediated protein transport (GO:0072321) | 5.74204751 |
19 | translational elongation (GO:0006414) | 5.68403589 |
20 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.57233002 |
21 | ribosomal large subunit biogenesis (GO:0042273) | 5.38460263 |
22 | cellular protein complex disassembly (GO:0043624) | 5.24860325 |
23 | viral life cycle (GO:0019058) | 5.11639206 |
24 | proteasome assembly (GO:0043248) | 5.09813791 |
25 | translational initiation (GO:0006413) | 5.08492760 |
26 | protein complex biogenesis (GO:0070271) | 4.97943580 |
27 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.92760516 |
28 | NADH dehydrogenase complex assembly (GO:0010257) | 4.92760516 |
29 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.92760516 |
30 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.89860117 |
31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.81332513 |
32 | translation (GO:0006412) | 4.81318404 |
33 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.47277463 |
34 | oxidative phosphorylation (GO:0006119) | 4.41713671 |
35 | protein complex disassembly (GO:0043241) | 4.39232331 |
36 | macromolecular complex disassembly (GO:0032984) | 4.28104406 |
37 | protein targeting to membrane (GO:0006612) | 4.23873013 |
38 | ATP biosynthetic process (GO:0006754) | 4.13623791 |
39 | termination of RNA polymerase III transcription (GO:0006386) | 4.08902305 |
40 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.08902305 |
41 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.02830223 |
42 | regulation of mitochondrial translation (GO:0070129) | 4.02204652 |
43 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.95001184 |
44 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.95001184 |
45 | hydrogen ion transmembrane transport (GO:1902600) | 3.82116548 |
46 | cellular component biogenesis (GO:0044085) | 3.81441435 |
47 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.78255015 |
48 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.78074572 |
49 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.70837049 |
50 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.70146179 |
51 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.65936752 |
52 | protein targeting to mitochondrion (GO:0006626) | 3.61773151 |
53 | mRNA catabolic process (GO:0006402) | 3.48731076 |
54 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.48630455 |
55 | regulation of cellular respiration (GO:0043457) | 3.48167419 |
56 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.46796707 |
57 | proton transport (GO:0015992) | 3.41295840 |
58 | hydrogen transport (GO:0006818) | 3.37743407 |
59 | spliceosomal snRNP assembly (GO:0000387) | 3.33756292 |
60 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.33107250 |
61 | spliceosomal complex assembly (GO:0000245) | 3.32965783 |
62 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.32557682 |
63 | establishment of protein localization to mitochondrion (GO:0072655) | 3.28215960 |
64 | protein localization to mitochondrion (GO:0070585) | 3.25620561 |
65 | regulation of cilium movement (GO:0003352) | 3.22595325 |
66 | respiratory chain complex IV assembly (GO:0008535) | 3.22280579 |
67 | RNA catabolic process (GO:0006401) | 3.19654005 |
68 | DNA deamination (GO:0045006) | 3.18286947 |
69 | organelle disassembly (GO:1903008) | 3.17836701 |
70 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.10430650 |
71 | rRNA processing (GO:0006364) | 3.09862152 |
72 | deoxyribonucleotide catabolic process (GO:0009264) | 3.08137769 |
73 | deoxyribose phosphate catabolic process (GO:0046386) | 3.06337930 |
74 | protein targeting (GO:0006605) | 3.03391833 |
75 | mitochondrial transport (GO:0006839) | 3.01754116 |
76 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.00625255 |
77 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.96976400 |
78 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.96976400 |
79 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.96901832 |
80 | rRNA metabolic process (GO:0016072) | 2.96705132 |
81 | chromatin remodeling at centromere (GO:0031055) | 2.96622907 |
82 | negative regulation of heart rate (GO:0010459) | 2.93214650 |
83 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.92496387 |
84 | cullin deneddylation (GO:0010388) | 2.90869256 |
85 | establishment of protein localization to membrane (GO:0090150) | 2.89031056 |
86 | cytochrome complex assembly (GO:0017004) | 2.88973911 |
87 | regulation of oxidative phosphorylation (GO:0002082) | 2.86792886 |
88 | response to redox state (GO:0051775) | 2.86224128 |
89 | peptidyl-histidine modification (GO:0018202) | 2.85172022 |
90 | histone mRNA metabolic process (GO:0008334) | 2.84945852 |
91 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.84664412 |
92 | ribonucleoprotein complex disassembly (GO:0032988) | 2.82328588 |
93 | DNA replication checkpoint (GO:0000076) | 2.79524357 |
94 | establishment of protein localization to organelle (GO:0072594) | 2.77019162 |
95 | rRNA modification (GO:0000154) | 2.76938091 |
96 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.76202067 |
97 | negative regulation of appetite (GO:0032099) | 2.75849322 |
98 | negative regulation of response to food (GO:0032096) | 2.75849322 |
99 | CENP-A containing nucleosome assembly (GO:0034080) | 2.68588473 |
100 | formation of translation preinitiation complex (GO:0001731) | 2.67106805 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.11282697 |
2 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.97876567 |
3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.81769074 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.95401310 |
5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.35586059 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.33443296 |
7 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.19239263 |
8 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.19107978 |
9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.14797261 |
10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.00837649 |
11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.95604670 |
12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.86069829 |
13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82257425 |
14 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.68713938 |
15 | VDR_22108803_ChIP-Seq_LS180_Human | 2.68292855 |
16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.67663577 |
17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.21201993 |
18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.20510024 |
19 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.04540208 |
20 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.03186975 |
21 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.00560407 |
22 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.88954552 |
23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.85124532 |
24 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.82775994 |
25 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.80984588 |
26 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.80218973 |
27 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.79871427 |
28 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.78324106 |
29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.78035274 |
30 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.75562306 |
31 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.73699180 |
32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.73508337 |
33 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.62427479 |
34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.60970748 |
35 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.57828830 |
36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.55893976 |
37 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.54494416 |
38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.54402230 |
39 | EWS_26573619_Chip-Seq_HEK293_Human | 1.49909529 |
40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.48972381 |
41 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.48153580 |
42 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.47973876 |
43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.47682528 |
44 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.47491362 |
45 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.47197356 |
46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.46502328 |
47 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.38510629 |
48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35119191 |
49 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.34764815 |
50 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28027484 |
51 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.27858783 |
52 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.22787184 |
53 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.22249924 |
54 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.21364998 |
55 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.20748278 |
56 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.19879209 |
57 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.17010225 |
58 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.15704233 |
59 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14573691 |
60 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.13972060 |
61 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.13521925 |
62 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.09167512 |
63 | AR_20517297_ChIP-Seq_VCAP_Human | 1.06711893 |
64 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06212276 |
65 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.04546121 |
66 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.04416610 |
67 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.01665112 |
68 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.00544931 |
69 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.98258406 |
70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.98004647 |
71 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96832232 |
72 | P300_19829295_ChIP-Seq_ESCs_Human | 0.96638132 |
73 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.95408184 |
74 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.94953554 |
75 | NCOR_22424771_ChIP-Seq_293T_Human | 0.93976527 |
76 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.93812727 |
77 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.93648120 |
78 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.93396271 |
79 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.91457266 |
80 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.90750552 |
81 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.90663492 |
82 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.90417604 |
83 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.89603468 |
84 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.88783576 |
85 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.88547375 |
86 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.88539247 |
87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.88331218 |
88 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.88156045 |
89 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.86903500 |
90 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.86715295 |
91 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.86715295 |
92 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.86666861 |
93 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.85528803 |
94 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.83885110 |
95 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.83610832 |
96 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.82115675 |
97 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.82115675 |
98 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.81720145 |
99 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.81351698 |
100 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.80742936 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 6.68422491 |
2 | MP0006292_abnormal_olfactory_placode | 4.12644995 |
3 | MP0003806_abnormal_nucleotide_metabolis | 3.33139135 |
4 | MP0002163_abnormal_gland_morphology | 3.21648630 |
5 | MP0005646_abnormal_pituitary_gland | 2.58806443 |
6 | MP0003186_abnormal_redox_activity | 2.50175400 |
7 | MP0002837_dystrophic_cardiac_calcinosis | 2.49598486 |
8 | MP0001529_abnormal_vocalization | 2.44221814 |
9 | MP0003880_abnormal_central_pattern | 2.40253851 |
10 | MP0005379_endocrine/exocrine_gland_phen | 2.25415446 |
11 | MP0004142_abnormal_muscle_tone | 2.19912816 |
12 | MP0002876_abnormal_thyroid_physiology | 2.16425098 |
13 | MP0008789_abnormal_olfactory_epithelium | 2.16297469 |
14 | MP0006072_abnormal_retinal_apoptosis | 2.15691881 |
15 | MP0001188_hyperpigmentation | 1.94365155 |
16 | MP0003123_paternal_imprinting | 1.93296453 |
17 | MP0004145_abnormal_muscle_electrophysio | 1.89048323 |
18 | MP0004147_increased_porphyrin_level | 1.74899481 |
19 | MP0006276_abnormal_autonomic_nervous | 1.73870756 |
20 | MP0003787_abnormal_imprinting | 1.72793814 |
21 | MP0001905_abnormal_dopamine_level | 1.71309679 |
22 | MP0008877_abnormal_DNA_methylation | 1.68240185 |
23 | MP0006036_abnormal_mitochondrial_physio | 1.65210656 |
24 | MP0002160_abnormal_reproductive_system | 1.63248176 |
25 | MP0003011_delayed_dark_adaptation | 1.62883724 |
26 | MP0003195_calcinosis | 1.60534125 |
27 | MP0005084_abnormal_gallbladder_morpholo | 1.59263609 |
28 | MP0005499_abnormal_olfactory_system | 1.57616641 |
29 | MP0005394_taste/olfaction_phenotype | 1.57616641 |
30 | MP0005389_reproductive_system_phenotype | 1.55831345 |
31 | MP0003567_abnormal_fetal_cardiomyocyte | 1.48450989 |
32 | MP0003786_premature_aging | 1.44962477 |
33 | MP0003646_muscle_fatigue | 1.41816368 |
34 | MP0000516_abnormal_urinary_system | 1.40268157 |
35 | MP0005367_renal/urinary_system_phenotyp | 1.40268157 |
36 | MP0000049_abnormal_middle_ear | 1.35471530 |
37 | MP0009697_abnormal_copulation | 1.34062935 |
38 | MP0000631_abnormal_neuroendocrine_gland | 1.33998195 |
39 | MP0002638_abnormal_pupillary_reflex | 1.32772109 |
40 | MP0002138_abnormal_hepatobiliary_system | 1.30537546 |
41 | MP0003121_genomic_imprinting | 1.29341444 |
42 | MP0001984_abnormal_olfaction | 1.29234214 |
43 | MP0005551_abnormal_eye_electrophysiolog | 1.25026338 |
44 | MP0010386_abnormal_urinary_bladder | 1.22987927 |
45 | MP0005636_abnormal_mineral_homeostasis | 1.22146302 |
46 | MP0001485_abnormal_pinna_reflex | 1.20980343 |
47 | MP0001293_anophthalmia | 1.18676186 |
48 | MP0003137_abnormal_impulse_conducting | 1.17350812 |
49 | MP0006035_abnormal_mitochondrial_morpho | 1.16643870 |
50 | MP0008875_abnormal_xenobiotic_pharmacok | 1.16449518 |
51 | MP0002938_white_spotting | 1.13358594 |
52 | MP0005670_abnormal_white_adipose | 1.13015749 |
53 | MP0001986_abnormal_taste_sensitivity | 1.12035902 |
54 | MP0003693_abnormal_embryo_hatching | 1.09479031 |
55 | MP0005645_abnormal_hypothalamus_physiol | 1.08466344 |
56 | MP0001919_abnormal_reproductive_system | 1.08214199 |
57 | MP0002272_abnormal_nervous_system | 1.08151816 |
58 | MP0009046_muscle_twitch | 1.06523261 |
59 | MP0001968_abnormal_touch/_nociception | 1.01771850 |
60 | MP0000372_irregular_coat_pigmentation | 1.00982513 |
61 | MP0003122_maternal_imprinting | 1.00810901 |
62 | MP0004957_abnormal_blastocyst_morpholog | 1.00683845 |
63 | MP0008872_abnormal_physiological_respon | 0.99580529 |
64 | MP0000566_synostosis | 0.97204863 |
65 | MP0002095_abnormal_skin_pigmentation | 0.94805636 |
66 | MP0002277_abnormal_respiratory_mucosa | 0.93959129 |
67 | MP0002736_abnormal_nociception_after | 0.93811093 |
68 | MP0009745_abnormal_behavioral_response | 0.93374047 |
69 | MP0005075_abnormal_melanosome_morpholog | 0.91339312 |
70 | MP0001727_abnormal_embryo_implantation | 0.90244396 |
71 | MP0002210_abnormal_sex_determination | 0.90089716 |
72 | MP0008995_early_reproductive_senescence | 0.89291153 |
73 | MP0001756_abnormal_urination | 0.85829664 |
74 | MP0005408_hypopigmentation | 0.85474172 |
75 | MP0002928_abnormal_bile_duct | 0.85418794 |
76 | MP0008058_abnormal_DNA_repair | 0.85154003 |
77 | MP0002102_abnormal_ear_morphology | 0.84008314 |
78 | MP0005332_abnormal_amino_acid | 0.83711457 |
79 | MP0003718_maternal_effect | 0.82102627 |
80 | MP0003938_abnormal_ear_development | 0.80335808 |
81 | MP0005410_abnormal_fertilization | 0.80249290 |
82 | MP0009780_abnormal_chondrocyte_physiolo | 0.79389309 |
83 | MP0000230_abnormal_systemic_arterial | 0.78132864 |
84 | MP0001970_abnormal_pain_threshold | 0.77637853 |
85 | MP0001440_abnormal_grooming_behavior | 0.76509107 |
86 | MP0001145_abnormal_male_reproductive | 0.75632042 |
87 | MP0001286_abnormal_eye_development | 0.74312295 |
88 | MP0000653_abnormal_sex_gland | 0.72984217 |
89 | MP0001765_abnormal_ion_homeostasis | 0.72304498 |
90 | MP0003315_abnormal_perineum_morphology | 0.72002840 |
91 | MP0005195_abnormal_posterior_eye | 0.70949480 |
92 | MP0005423_abnormal_somatic_nervous | 0.69364381 |
93 | MP0002733_abnormal_thermal_nociception | 0.66627376 |
94 | MP0003638_abnormal_response/metabolism_ | 0.66233902 |
95 | MP0005253_abnormal_eye_physiology | 0.65972563 |
96 | MP0003890_abnormal_embryonic-extraembry | 0.64082041 |
97 | MP0001324_abnormal_eye_pigmentation | 0.63763190 |
98 | MP0002557_abnormal_social/conspecific_i | 0.63290567 |
99 | MP0000427_abnormal_hair_cycle | 0.63113015 |
100 | MP0001764_abnormal_homeostasis | 0.62931188 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.15094533 |
2 | 3-Methylglutaconic aciduria (HP:0003535) | 5.98459546 |
3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.55618394 |
4 | Mitochondrial inheritance (HP:0001427) | 5.26643076 |
5 | Acute encephalopathy (HP:0006846) | 5.23326210 |
6 | Progressive macrocephaly (HP:0004481) | 5.14342759 |
7 | Increased CSF lactate (HP:0002490) | 4.72600791 |
8 | Hepatocellular necrosis (HP:0001404) | 4.39262614 |
9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.21682820 |
10 | Lipid accumulation in hepatocytes (HP:0006561) | 4.20217952 |
11 | Hepatic necrosis (HP:0002605) | 4.14418679 |
12 | Cerebral edema (HP:0002181) | 4.07685630 |
13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.02941808 |
14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.02941808 |
15 | Macrocytic anemia (HP:0001972) | 3.99184063 |
16 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.76707787 |
17 | Congenital, generalized hypertrichosis (HP:0004540) | 3.69205966 |
18 | Renal Fanconi syndrome (HP:0001994) | 3.49885017 |
19 | Abnormal number of erythroid precursors (HP:0012131) | 3.29516193 |
20 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.24564873 |
21 | Abnormality of alanine metabolism (HP:0010916) | 3.24564873 |
22 | Hyperalaninemia (HP:0003348) | 3.24564873 |
23 | Increased serum lactate (HP:0002151) | 3.16425440 |
24 | Aplastic anemia (HP:0001915) | 3.15984593 |
25 | Methylmalonic acidemia (HP:0002912) | 3.10857307 |
26 | Reticulocytopenia (HP:0001896) | 3.10645339 |
27 | Lactic acidosis (HP:0003128) | 3.10491400 |
28 | Exertional dyspnea (HP:0002875) | 3.07017523 |
29 | Increased serum pyruvate (HP:0003542) | 3.04351194 |
30 | Respiratory failure (HP:0002878) | 2.91637867 |
31 | Leukodystrophy (HP:0002415) | 2.90672879 |
32 | Increased intramyocellular lipid droplets (HP:0012240) | 2.86415315 |
33 | Optic disc pallor (HP:0000543) | 2.77674035 |
34 | Respiratory difficulties (HP:0002880) | 2.77592772 |
35 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.74588193 |
36 | Increased muscle lipid content (HP:0009058) | 2.60363680 |
37 | Exercise intolerance (HP:0003546) | 2.59191314 |
38 | Pallor (HP:0000980) | 2.54452569 |
39 | Medial flaring of the eyebrow (HP:0010747) | 2.53935814 |
40 | Abnormality of renal resorption (HP:0011038) | 2.52493674 |
41 | Colon cancer (HP:0003003) | 2.48413135 |
42 | Lethargy (HP:0001254) | 2.48085124 |
43 | Molar tooth sign on MRI (HP:0002419) | 2.47588094 |
44 | Abnormality of midbrain morphology (HP:0002418) | 2.47588094 |
45 | Stenosis of the external auditory canal (HP:0000402) | 2.41284861 |
46 | Methylmalonic aciduria (HP:0012120) | 2.38817466 |
47 | Pancreatic cysts (HP:0001737) | 2.37269001 |
48 | Glycosuria (HP:0003076) | 2.25752694 |
49 | Abnormality of urine glucose concentration (HP:0011016) | 2.25752694 |
50 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.24975456 |
51 | Congenital primary aphakia (HP:0007707) | 2.21215898 |
52 | Abnormality of serum amino acid levels (HP:0003112) | 2.20549184 |
53 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.18736201 |
54 | Gait imbalance (HP:0002141) | 2.18531621 |
55 | Abnormality of glycolysis (HP:0004366) | 2.15393021 |
56 | Generalized aminoaciduria (HP:0002909) | 2.14443715 |
57 | Thyroid-stimulating hormone excess (HP:0002925) | 2.06821619 |
58 | Testicular atrophy (HP:0000029) | 2.06794284 |
59 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.06445114 |
60 | Microvesicular hepatic steatosis (HP:0001414) | 2.02364273 |
61 | CNS demyelination (HP:0007305) | 2.01358891 |
62 | Abnormality of magnesium homeostasis (HP:0004921) | 2.00828526 |
63 | X-linked dominant inheritance (HP:0001423) | 2.00182155 |
64 | Microretrognathia (HP:0000308) | 1.97644018 |
65 | Hyperphosphaturia (HP:0003109) | 1.96784221 |
66 | Hyperglycinemia (HP:0002154) | 1.95664626 |
67 | Nephrogenic diabetes insipidus (HP:0009806) | 1.94942676 |
68 | Dicarboxylic aciduria (HP:0003215) | 1.94053409 |
69 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.94053409 |
70 | Triphalangeal thumb (HP:0001199) | 1.93736200 |
71 | Degeneration of anterior horn cells (HP:0002398) | 1.90652861 |
72 | Abnormality of the anterior horn cell (HP:0006802) | 1.90652861 |
73 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.87949733 |
74 | Woolly hair (HP:0002224) | 1.87627742 |
75 | Type I transferrin isoform profile (HP:0003642) | 1.87626955 |
76 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.86381439 |
77 | Delayed CNS myelination (HP:0002188) | 1.85844025 |
78 | Hypothermia (HP:0002045) | 1.81713816 |
79 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.81020413 |
80 | Type 2 muscle fiber atrophy (HP:0003554) | 1.78526037 |
81 | Megaloblastic anemia (HP:0001889) | 1.78331575 |
82 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.78238024 |
83 | Abnormality of vitamin B metabolism (HP:0004340) | 1.78032808 |
84 | Pancreatic fibrosis (HP:0100732) | 1.77839834 |
85 | Hypoplasia of the radius (HP:0002984) | 1.75844241 |
86 | Parakeratosis (HP:0001036) | 1.75040415 |
87 | Nephronophthisis (HP:0000090) | 1.73663016 |
88 | Abnormal hemoglobin (HP:0011902) | 1.72735873 |
89 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.72722499 |
90 | Congenital stationary night blindness (HP:0007642) | 1.72482385 |
91 | Abolished electroretinogram (ERG) (HP:0000550) | 1.71433771 |
92 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.70552495 |
93 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.70239854 |
94 | Vomiting (HP:0002013) | 1.65581373 |
95 | Hypomagnesemia (HP:0002917) | 1.64885006 |
96 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.63316538 |
97 | Cleft eyelid (HP:0000625) | 1.61028141 |
98 | Genital tract atresia (HP:0001827) | 1.59801578 |
99 | Rectovaginal fistula (HP:0000143) | 1.58218802 |
100 | Rectal fistula (HP:0100590) | 1.58218802 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NME2 | 3.26086360 |
2 | MAP3K12 | 2.77438795 |
3 | VRK2 | 2.76640845 |
4 | BUB1 | 2.68431505 |
5 | BCKDK | 2.61902375 |
6 | STK16 | 2.56313616 |
7 | ZAK | 2.28174459 |
8 | TLK1 | 2.04186597 |
9 | ARAF | 1.88732067 |
10 | TNIK | 1.88556455 |
11 | CDK19 | 1.85607965 |
12 | MAP4K2 | 1.85315319 |
13 | PLK4 | 1.84727913 |
14 | NEK1 | 1.80139964 |
15 | ILK | 1.76914092 |
16 | BMPR1B | 1.75395165 |
17 | MYLK | 1.73325556 |
18 | GRK1 | 1.72046121 |
19 | PDK2 | 1.70993849 |
20 | LIMK1 | 1.61253667 |
21 | ADRBK2 | 1.55107030 |
22 | EIF2AK3 | 1.53547750 |
23 | DYRK2 | 1.42759348 |
24 | NUAK1 | 1.35797741 |
25 | CDC7 | 1.35328347 |
26 | RPS6KA4 | 1.33540751 |
27 | PHKG2 | 1.33122380 |
28 | PHKG1 | 1.33122380 |
29 | WNK4 | 1.29525717 |
30 | PIM2 | 1.28704192 |
31 | WNK3 | 1.27975862 |
32 | MST4 | 1.27872049 |
33 | CSNK1G3 | 1.24127255 |
34 | VRK1 | 1.21479632 |
35 | SRPK1 | 1.21120647 |
36 | CSNK1G1 | 1.20338358 |
37 | MAP2K7 | 1.16702897 |
38 | TRIM28 | 1.12324073 |
39 | FRK | 1.08980090 |
40 | CSNK1G2 | 1.07254828 |
41 | EIF2AK1 | 1.06209128 |
42 | PIK3CA | 1.00710130 |
43 | CHEK2 | 0.99437979 |
44 | CDK8 | 0.98665170 |
45 | ABL2 | 0.91725384 |
46 | MAP3K9 | 0.89147644 |
47 | OXSR1 | 0.87333753 |
48 | CDK3 | 0.84785304 |
49 | TIE1 | 0.83009015 |
50 | AURKB | 0.82241468 |
51 | ACVR1B | 0.80527853 |
52 | OBSCN | 0.79720588 |
53 | DAPK3 | 0.79309840 |
54 | TNK2 | 0.78830173 |
55 | CSNK1A1L | 0.78074953 |
56 | INSRR | 0.77522071 |
57 | CSNK2A2 | 0.77278160 |
58 | IKBKB | 0.76415571 |
59 | RPS6KA5 | 0.72943123 |
60 | CSNK1A1 | 0.72349829 |
61 | PLK3 | 0.72311789 |
62 | BMPR2 | 0.71908954 |
63 | BRAF | 0.71553148 |
64 | PLK1 | 0.70979163 |
65 | DAPK1 | 0.70197423 |
66 | TEC | 0.70168037 |
67 | PINK1 | 0.68657253 |
68 | CSNK2A1 | 0.68183223 |
69 | TESK2 | 0.67801786 |
70 | DMPK | 0.67129703 |
71 | ATR | 0.64615651 |
72 | PRKCQ | 0.61880951 |
73 | KDR | 0.60664633 |
74 | CAMK1 | 0.59885517 |
75 | TGFBR1 | 0.57811588 |
76 | ADRBK1 | 0.56763388 |
77 | TXK | 0.55900810 |
78 | EIF2AK2 | 0.54551681 |
79 | PASK | 0.54414942 |
80 | AURKA | 0.54079176 |
81 | CAMKK2 | 0.53924464 |
82 | STK39 | 0.53899490 |
83 | CCNB1 | 0.52949104 |
84 | MKNK1 | 0.52705635 |
85 | MAP3K4 | 0.51925099 |
86 | PRKACA | 0.51360016 |
87 | PRKG1 | 0.51143550 |
88 | PRKCG | 0.50085864 |
89 | PLK2 | 0.49439177 |
90 | PAK1 | 0.48721177 |
91 | ERBB3 | 0.43720065 |
92 | CAMK2A | 0.43455466 |
93 | NEK2 | 0.42589506 |
94 | BRSK2 | 0.42411356 |
95 | NME1 | 0.41560227 |
96 | PIK3CG | 0.41043886 |
97 | KIT | 0.39515978 |
98 | CASK | 0.38820520 |
99 | LYN | 0.38543790 |
100 | CSNK1E | 0.38470092 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 6.04182185 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 5.20695029 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.40003844 |
4 | Protein export_Homo sapiens_hsa03060 | 3.75727182 |
5 | Proteasome_Homo sapiens_hsa03050 | 3.36190549 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.06620142 |
7 | Alzheimers disease_Homo sapiens_hsa05010 | 3.04919138 |
8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.71180471 |
9 | RNA polymerase_Homo sapiens_hsa03020 | 2.50776153 |
10 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.41614917 |
11 | Mismatch repair_Homo sapiens_hsa03430 | 2.07415029 |
12 | Asthma_Homo sapiens_hsa05310 | 2.04642118 |
13 | Homologous recombination_Homo sapiens_hsa03440 | 1.91091699 |
14 | DNA replication_Homo sapiens_hsa03030 | 1.80297827 |
15 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.50899011 |
16 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.50191641 |
17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.49033867 |
18 | Spliceosome_Homo sapiens_hsa03040 | 1.48556979 |
19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.46848431 |
20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.41220493 |
21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.32810400 |
22 | RNA degradation_Homo sapiens_hsa03018 | 1.32041003 |
23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.31629430 |
24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.22088143 |
25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.20295931 |
26 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.18370017 |
27 | Purine metabolism_Homo sapiens_hsa00230 | 1.16449342 |
28 | Base excision repair_Homo sapiens_hsa03410 | 1.15116978 |
29 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.13712490 |
30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.03948088 |
31 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.02300425 |
32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.01139396 |
33 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.00769972 |
34 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.99583760 |
35 | RNA transport_Homo sapiens_hsa03013 | 0.99364815 |
36 | Allograft rejection_Homo sapiens_hsa05330 | 0.97387628 |
37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.95113632 |
38 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.94258010 |
39 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.91539730 |
40 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.91445240 |
41 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.90708115 |
42 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.83052141 |
43 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.79934026 |
44 | Phototransduction_Homo sapiens_hsa04744 | 0.78613736 |
45 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.77430666 |
46 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72647543 |
47 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.72465872 |
48 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.70934584 |
49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.68293030 |
50 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.67909681 |
51 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.67024953 |
52 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.66666669 |
53 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.63884826 |
54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.63446157 |
55 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.59323330 |
56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.57735467 |
57 | Peroxisome_Homo sapiens_hsa04146 | 0.57455385 |
58 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.55162724 |
59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54154263 |
60 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.53783885 |
61 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.52535572 |
62 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.51872555 |
63 | Nicotine addiction_Homo sapiens_hsa05033 | 0.50933747 |
64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.50554974 |
65 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48361059 |
66 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.47920040 |
67 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.47753503 |
68 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.46668712 |
69 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.46289786 |
70 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.45185236 |
71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.41230971 |
72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39397470 |
73 | Sulfur relay system_Homo sapiens_hsa04122 | 0.39387365 |
74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37354402 |
75 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.37148512 |
76 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.36721737 |
77 | Olfactory transduction_Homo sapiens_hsa04740 | 0.33650327 |
78 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33043587 |
79 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.32063679 |
80 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30275748 |
81 | Viral myocarditis_Homo sapiens_hsa05416 | 0.30196937 |
82 | Morphine addiction_Homo sapiens_hsa05032 | 0.29141643 |
83 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.28459812 |
84 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.27674943 |
85 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26509279 |
86 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.26428876 |
87 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.25799812 |
88 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.24393646 |
89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.21636635 |
90 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.20016729 |
91 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.19943243 |
92 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.18701538 |
93 | Cell cycle_Homo sapiens_hsa04110 | 0.17414039 |
94 | Mineral absorption_Homo sapiens_hsa04978 | 0.16322176 |
95 | GABAergic synapse_Homo sapiens_hsa04727 | 0.14950182 |
96 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.14569542 |
97 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.14350748 |
98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.14053832 |
99 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.13870972 |
100 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.07346347 |