DNAJC21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the precursor 45S ribosomal RNA and may be involved in early nuclear ribosomal RNA biogenesis and maturation of the 60S ribosomal subunit. Mutations in this gene result in Bone marrow failure syndrome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.00884475
2metaphase plate congression (GO:0051310)4.93221552
3ribosome assembly (GO:0042255)4.73228328
4nuclear pore organization (GO:0006999)4.69258805
5protein localization to kinetochore (GO:0034501)4.52541699
6DNA replication checkpoint (GO:0000076)4.51026106
7nuclear pore complex assembly (GO:0051292)4.50650889
8regulation of spindle organization (GO:0090224)4.48130700
9regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.32194012
10protein K6-linked ubiquitination (GO:0085020)4.31475602
11regulation of DNA endoreduplication (GO:0032875)4.29765414
12monoubiquitinated protein deubiquitination (GO:0035520)4.21139599
13DNA unwinding involved in DNA replication (GO:0006268)4.20709407
14protein localization to chromosome, centromeric region (GO:0071459)4.15918107
15establishment of chromosome localization (GO:0051303)4.11383614
16purine nucleobase biosynthetic process (GO:0009113)4.10662499
17ribosome biogenesis (GO:0042254)4.10462185
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03474156
19regulation of RNA export from nucleus (GO:0046831)3.98614499
20formation of translation preinitiation complex (GO:0001731)3.98422048
21mitotic chromosome condensation (GO:0007076)3.96507829
22positive regulation of chromosome segregation (GO:0051984)3.92531412
23nucleobase biosynthetic process (GO:0046112)3.91135962
24mitotic nuclear envelope disassembly (GO:0007077)3.90658453
25mitotic sister chromatid segregation (GO:0000070)3.89467911
26mitotic sister chromatid cohesion (GO:0007064)3.88381918
27regulation of mitotic spindle organization (GO:0060236)3.88159838
28histone H2A monoubiquitination (GO:0035518)3.79840284
29intestinal epithelial cell development (GO:0060576)3.76782207
30regulation of centriole replication (GO:0046599)3.76131498
31ribosomal small subunit biogenesis (GO:0042274)3.70766006
32membrane disassembly (GO:0030397)3.65807668
33nuclear envelope disassembly (GO:0051081)3.65807668
34regulation of double-strand break repair via homologous recombination (GO:0010569)3.64161711
35kinetochore organization (GO:0051383)3.59158644
36inner cell mass cell proliferation (GO:0001833)3.59014930
37attachment of spindle microtubules to kinetochore (GO:0008608)3.58179341
38rRNA modification (GO:0000154)3.52428274
39maturation of 5.8S rRNA (GO:0000460)3.50651831
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.49512341
41positive regulation of mitotic sister chromatid separation (GO:1901970)3.48847558
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48847558
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48847558
44spindle checkpoint (GO:0031577)3.47400435
45kinetochore assembly (GO:0051382)3.47251939
46protein localization to chromosome (GO:0034502)3.45804651
47DNA replication initiation (GO:0006270)3.45439506
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.41781340
49pore complex assembly (GO:0046931)3.41552957
50maturation of SSU-rRNA (GO:0030490)3.41399224
51heterochromatin organization (GO:0070828)3.41230252
52chromatin remodeling at centromere (GO:0031055)3.38459824
53DNA strand elongation involved in DNA replication (GO:0006271)3.38389930
54ribosomal large subunit biogenesis (GO:0042273)3.36286036
55DNA replication-dependent nucleosome assembly (GO:0006335)3.34570009
56DNA replication-dependent nucleosome organization (GO:0034723)3.34570009
57histone exchange (GO:0043486)3.34544536
58sister chromatid segregation (GO:0000819)3.33747894
59regulation of chromosome segregation (GO:0051983)3.33387040
60negative regulation of DNA repair (GO:0045738)3.32301819
61CENP-A containing nucleosome assembly (GO:0034080)3.31381610
62DNA replication-independent nucleosome assembly (GO:0006336)3.31375705
63DNA replication-independent nucleosome organization (GO:0034724)3.31375705
64regulation of centrosome duplication (GO:0010824)3.27775630
65regulation of centrosome cycle (GO:0046605)3.26240484
66regulation of posttranscriptional gene silencing (GO:0060147)3.26027365
67regulation of gene silencing by miRNA (GO:0060964)3.26027365
68regulation of gene silencing by RNA (GO:0060966)3.26027365
69pre-miRNA processing (GO:0031054)3.25145315
70DNA strand elongation (GO:0022616)3.23369154
71mitotic spindle checkpoint (GO:0071174)3.20555563
72folic acid metabolic process (GO:0046655)3.20262961
73regulation of translational fidelity (GO:0006450)3.19643074
74non-recombinational repair (GO:0000726)3.19268890
75double-strand break repair via nonhomologous end joining (GO:0006303)3.19268890
76ribonucleoprotein complex biogenesis (GO:0022613)3.17133679
77transcription elongation from RNA polymerase I promoter (GO:0006362)3.16380138
78establishment of protein localization to mitochondrial membrane (GO:0090151)3.15852031
79DNA duplex unwinding (GO:0032508)3.15683442
80regulation of sister chromatid cohesion (GO:0007063)3.15607809
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.11258957
82termination of RNA polymerase I transcription (GO:0006363)3.09637447
83negative regulation of chromosome segregation (GO:0051985)3.09525799
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08959347
85transcription from RNA polymerase I promoter (GO:0006360)3.08639962
86replication fork processing (GO:0031297)3.08028790
87negative regulation of translational initiation (GO:0045947)3.07608166
88negative regulation of histone methylation (GO:0031061)3.06584939
89regulation of helicase activity (GO:0051095)3.05474238
90DNA geometric change (GO:0032392)3.05231293
91chromatin assembly or disassembly (GO:0006333)3.04144872
92regulation of nucleobase-containing compound transport (GO:0032239)3.03619653
93regulation of histone H3-K9 methylation (GO:0051570)3.03399453
94sister chromatid cohesion (GO:0007062)3.02699647
95chromosome segregation (GO:0007059)3.02257441
96rRNA processing (GO:0006364)3.02145096
97IMP biosynthetic process (GO:0006188)3.02115251
98histone H2A ubiquitination (GO:0033522)3.00905318
99mitotic G2/M transition checkpoint (GO:0044818)3.00584533
100rRNA methylation (GO:0031167)3.00265812
101positive regulation of histone H3-K4 methylation (GO:0051571)2.99783967
102regulation of meiosis I (GO:0060631)2.99643924
103synaptonemal complex assembly (GO:0007130)2.99212448
104telomere maintenance via semi-conservative replication (GO:0032201)2.99141660
105DNA topological change (GO:0006265)2.99080690
106nuclear envelope organization (GO:0006998)2.98056228
107meiotic chromosome segregation (GO:0045132)2.97740259
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.97108513
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97108513
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97108513
111negative regulation of sister chromatid segregation (GO:0033046)2.97108513
112rRNA metabolic process (GO:0016072)2.96900405
113regulation of translation in response to stress (GO:0043555)2.96521126
114regulation of double-strand break repair (GO:2000779)2.96063009
115regulation of sister chromatid segregation (GO:0033045)2.95889512
116regulation of mitotic sister chromatid separation (GO:0010965)2.95889512
117regulation of mitotic sister chromatid segregation (GO:0033047)2.95889512
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94548737
119spindle assembly checkpoint (GO:0071173)2.93681892
120mitotic recombination (GO:0006312)2.90195372
121chromosome condensation (GO:0030261)2.86833601
122regulation of DNA-dependent DNA replication (GO:0090329)2.86491638
123IMP metabolic process (GO:0046040)2.83556772
124DNA conformation change (GO:0071103)2.82188719
125telomere maintenance via recombination (GO:0000722)2.79578334
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.79218335
127cellular protein complex localization (GO:0034629)2.78557666
128folic acid-containing compound biosynthetic process (GO:0009396)2.76151135
129regulation of translational termination (GO:0006449)2.71232384
130telomere maintenance via telomerase (GO:0007004)2.69132500
131DNA packaging (GO:0006323)2.67624841
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.64757974
133spindle assembly involved in mitosis (GO:0090307)2.64526157
134nucleobase-containing small molecule interconversion (GO:0015949)2.61945557
135establishment of integrated proviral latency (GO:0075713)2.58879422
136protein complex localization (GO:0031503)2.57784207
137ribosomal small subunit assembly (GO:0000028)2.55730755
138negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.53464212
139mitotic G2 DNA damage checkpoint (GO:0007095)2.52794770
140regulation of DNA damage checkpoint (GO:2000001)2.52071547
141RNA-dependent DNA replication (GO:0006278)2.50136986
142protein export from nucleus (GO:0006611)2.49819699
143paraxial mesoderm development (GO:0048339)2.47964908
144AMP metabolic process (GO:0046033)2.46015006
145translational initiation (GO:0006413)2.45691689
146tetrahydrofolate metabolic process (GO:0046653)2.45453832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.75099347
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.76419004
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.94242988
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.92084718
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59961084
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.36809846
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97620940
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81252843
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74802338
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74685207
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68883955
12AR_21909140_ChIP-Seq_LNCAP_Human2.65530837
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.56706682
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54369352
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.48915391
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.48254634
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38345269
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.37836976
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35547147
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27369968
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26349955
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25745938
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16357315
24NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14494981
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.13081604
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.08633591
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07139698
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.05186361
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04159400
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04159400
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04159400
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.01730546
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.99600395
34* VDR_23849224_ChIP-Seq_CD4+_Human1.97765592
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86998313
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85509416
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83404447
38XRN2_22483619_ChIP-Seq_HELA_Human1.82222770
39KDM5A_27292631_Chip-Seq_BREAST_Human1.75998606
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75736261
41GABP_19822575_ChIP-Seq_HepG2_Human1.70817482
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.68983367
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67570827
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66490291
45ZNF263_19887448_ChIP-Seq_K562_Human1.65508800
46DCP1A_22483619_ChIP-Seq_HELA_Human1.62145789
47FOXP3_21729870_ChIP-Seq_TREG_Human1.60381680
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56417347
49TTF2_22483619_ChIP-Seq_HELA_Human1.54686916
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54111359
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54058675
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47617209
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44885598
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.44260181
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44042194
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43082569
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42618460
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.37761643
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.35980349
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34926546
61FUS_26573619_Chip-Seq_HEK293_Human1.33661446
62ELK1_19687146_ChIP-ChIP_HELA_Human1.32845130
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30135655
64EWS_26573619_Chip-Seq_HEK293_Human1.28670569
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28618247
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27644744
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26911693
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21458361
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20196717
70* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20148699
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19913700
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19274184
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15817630
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15461450
75GATA1_22025678_ChIP-Seq_K562_Human1.14889718
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13972076
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12971513
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11877962
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10176771
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09543772
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09177770
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09082111
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07443632
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03711067
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01574890
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01301228
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.00559745
88NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00121234
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99977499
90TFEB_21752829_ChIP-Seq_HELA_Human0.99748746
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99411571
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98748669
93MYC_22102868_ChIP-Seq_BL_Human0.98301250
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.98059288
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97687346
96CIITA_25753668_ChIP-Seq_RAJI_Human0.96834116
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95912722
98GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95060374
99KAP1_27257070_Chip-Seq_ESCs_Mouse0.93958779
100NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93056016
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92249111
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92130170
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92102746
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91672732
105ELF5_23300383_ChIP-Seq_T47D_Human0.90524399
106BRD4_25478319_ChIP-Seq_HGPS_Human0.90437161
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90371395
108NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90314906
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90263731
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90150017
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89209352
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88650203
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.88633370
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87408883
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87408883
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.85796089
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85533750
118SOX2_18692474_ChIP-Seq_MESCs_Mouse0.83982770
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83011712
120* CHD1_26751641_Chip-Seq_LNCaP_Human0.82087135
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.81544646
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81014127
123MYC_18940864_ChIP-ChIP_HL60_Human0.80173285
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79689116
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.79473130
126SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79396308
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78313556
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78062281
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77967812
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.77703723
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77642406
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76785280
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76296101
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75659882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.69790845
2MP0008057_abnormal_DNA_replication4.69803797
3MP0004957_abnormal_blastocyst_morpholog4.49999933
4MP0003111_abnormal_nucleus_morphology4.37447065
5MP0010094_abnormal_chromosome_stability4.08832312
6MP0003077_abnormal_cell_cycle3.68446368
7MP0008058_abnormal_DNA_repair2.90384730
8MP0003718_maternal_effect2.89862432
9MP0001730_embryonic_growth_arrest2.74398422
10MP0008877_abnormal_DNA_methylation2.59800701
11MP0003123_paternal_imprinting2.50248955
12MP0008932_abnormal_embryonic_tissue2.30692971
13MP0000350_abnormal_cell_proliferation2.25170869
14MP0001672_abnormal_embryogenesis/_devel2.23957022
15MP0005380_embryogenesis_phenotype2.23957022
16MP0008007_abnormal_cellular_replicative2.14808927
17MP0003984_embryonic_growth_retardation1.96760483
18MP0001697_abnormal_embryo_size1.96591944
19MP0002088_abnormal_embryonic_growth/wei1.92285634
20MP0002084_abnormal_developmental_patter1.91695559
21MP0003786_premature_aging1.89965367
22MP0010307_abnormal_tumor_latency1.86554884
23MP0002085_abnormal_embryonic_tissue1.85290784
24MP0009697_abnormal_copulation1.81938801
25MP0005451_abnormal_body_composition1.77927150
26MP0004185_abnormal_adipocyte_glucose1.77492740
27MP0003890_abnormal_embryonic-extraembry1.76515101
28MP0002086_abnormal_extraembryonic_tissu1.69810639
29MP0003646_muscle_fatigue1.65042700
30MP0005408_hypopigmentation1.61213203
31MP0002210_abnormal_sex_determination1.59781226
32MP0002080_prenatal_lethality1.57746045
33MP0010352_gastrointestinal_tract_polyps1.54948616
34MP0004197_abnormal_fetal_growth/weight/1.50119151
35MP0005076_abnormal_cell_differentiation1.49823690
36MP0001929_abnormal_gametogenesis1.48905611
37MP0002009_preneoplasia1.46502151
38MP0004036_abnormal_muscle_relaxation1.40723663
39MP0001145_abnormal_male_reproductive1.39443005
40MP0003567_abnormal_fetal_cardiomyocyte1.34934786
41MP0003121_genomic_imprinting1.32587408
42MP0000750_abnormal_muscle_regeneration1.31081605
43MP0002837_dystrophic_cardiac_calcinosis1.29969159
44MP0006292_abnormal_olfactory_placode1.29836997
45MP0000653_abnormal_sex_gland1.29231996
46MP0004808_abnormal_hematopoietic_stem1.27892117
47MP0001849_ear_inflammation1.27431458
48MP0002653_abnormal_ependyma_morphology1.26922152
49MP0010678_abnormal_skin_adnexa1.26581445
50MP0003221_abnormal_cardiomyocyte_apopto1.26530483
51MP0003941_abnormal_skin_development1.26288227
52MP0004264_abnormal_extraembryonic_tissu1.26125361
53MP0002396_abnormal_hematopoietic_system1.20988528
54MP0003119_abnormal_digestive_system1.20876855
55MP0000749_muscle_degeneration1.20827082
56MP0000313_abnormal_cell_death1.16058648
57MP0003937_abnormal_limbs/digits/tail_de1.15323216
58MP0004087_abnormal_muscle_fiber1.13779245
59MP0005257_abnormal_intraocular_pressure1.12412787
60MP0009780_abnormal_chondrocyte_physiolo1.11770827
61MP0002877_abnormal_melanocyte_morpholog1.11567144
62MP0009672_abnormal_birth_weight1.10988272
63MP0005083_abnormal_biliary_tract1.09930308
64MP0000383_abnormal_hair_follicle1.07779122
65MP0005395_other_phenotype1.07557165
66MP0001293_anophthalmia1.03695962
67MP0002019_abnormal_tumor_incidence1.02458287
68MP0003806_abnormal_nucleotide_metabolis1.00979462
69MP0009703_decreased_birth_body0.99993146
70MP0000759_abnormal_skeletal_muscle0.97012093
71MP0002163_abnormal_gland_morphology0.95685768
72MP0008260_abnormal_autophagy0.94615743
73MP0003950_abnormal_plasma_membrane0.93969767
74MP0001119_abnormal_female_reproductive0.93963337
75MP0003186_abnormal_redox_activity0.93707972
76MP0001348_abnormal_lacrimal_gland0.90306976
77MP0005330_cardiomyopathy0.89644575
78MP0003699_abnormal_female_reproductive0.89613551
79MP0000490_abnormal_crypts_of0.89551289
80MP0000003_abnormal_adipose_tissue0.88819409
81MP0006036_abnormal_mitochondrial_physio0.88618752
82MP0000537_abnormal_urethra_morphology0.87624769
83MP0003136_yellow_coat_color0.87065722
84MP0000013_abnormal_adipose_tissue0.86548258
85MP0003698_abnormal_male_reproductive0.86436600
86MP0002269_muscular_atrophy0.84817574
87MP0010630_abnormal_cardiac_muscle0.82763573
88MP0003315_abnormal_perineum_morphology0.82724107
89MP0009250_abnormal_appendicular_skeleto0.80653015
90MP0002127_abnormal_cardiovascular_syste0.80621951
91MP0002060_abnormal_skin_morphology0.79799929
92MP0004145_abnormal_muscle_electrophysio0.79512022
93MP0002161_abnormal_fertility/fecundity0.79150037
94MP0003705_abnormal_hypodermis_morpholog0.78824805
95MP0004084_abnormal_cardiac_muscle0.78773508
96MP0000747_muscle_weakness0.77985221
97MP0000432_abnormal_head_morphology0.77853835
98MP0005621_abnormal_cell_physiology0.77686053
99MP0003755_abnormal_palate_morphology0.77421770
100MP0003787_abnormal_imprinting0.76437932
101MP0009333_abnormal_splenocyte_physiolog0.75903147
102MP0004134_abnormal_chest_morphology0.74264615
103MP0005389_reproductive_system_phenotype0.73993300
104MP0006035_abnormal_mitochondrial_morpho0.73807570
105MP0003943_abnormal_hepatobiliary_system0.73062455
106MP0005384_cellular_phenotype0.72582966
107MP0005666_abnormal_adipose_tissue0.72404344
108MP0002166_altered_tumor_susceptibility0.71739325
109MP0001286_abnormal_eye_development0.71654636
110MP0002160_abnormal_reproductive_system0.71608388
111MP0003936_abnormal_reproductive_system0.71576023
112MP0003656_abnormal_erythrocyte_physiolo0.71232450
113MP0000627_abnormal_mammary_gland0.71110446
114MP0004215_abnormal_myocardial_fiber0.70230718
115MP0003935_abnormal_craniofacial_develop0.70115913
116MP0003566_abnormal_cell_adhesion0.68895794
117MP0004147_increased_porphyrin_level0.68878975
118MP0002106_abnormal_muscle_physiology0.67702561
119MP0002697_abnormal_eye_size0.67591925
120MP0000428_abnormal_craniofacial_morphol0.67509688
121MP0002108_abnormal_muscle_morphology0.67333633
122MP0001881_abnormal_mammary_gland0.67000881
123MP0002138_abnormal_hepatobiliary_system0.66688338
124MP0005369_muscle_phenotype0.65377470
125MP0005266_abnormal_metabolism0.64228002
126MP0001545_abnormal_hematopoietic_system0.63934088
127MP0005397_hematopoietic_system_phenotyp0.63934088
128MP0002796_impaired_skin_barrier0.63647890
129MP0000733_abnormal_muscle_development0.63566626
130MP0010234_abnormal_vibrissa_follicle0.61964126
131MP0004233_abnormal_muscle_weight0.61165582
132MP0005501_abnormal_skin_physiology0.61029358
133MP0003938_abnormal_ear_development0.60827362
134MP0001661_extended_life_span0.59747352
135MP0002092_abnormal_eye_morphology0.58241209
136MP0000516_abnormal_urinary_system0.57996821
137MP0005367_renal/urinary_system_phenotyp0.57996821
138MP0000358_abnormal_cell_content/0.55778368

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.73890325
2Impulsivity (HP:0100710)5.21172042
3Breast hypoplasia (HP:0003187)4.74679425
4Chromsome breakage (HP:0040012)4.25414532
5Abnormality of the labia minora (HP:0012880)4.16366561
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10442989
7Nemaline bodies (HP:0003798)4.02230998
8Patellar aplasia (HP:0006443)3.85714752
9Muscle fiber inclusion bodies (HP:0100299)3.82799618
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.78758163
11Aplasia/Hypoplasia of the patella (HP:0006498)3.64456566
12Facial hemangioma (HP:0000329)3.52720846
13Carpal bone hypoplasia (HP:0001498)3.52007282
14Hyperglycinemia (HP:0002154)3.43293653
15Absent radius (HP:0003974)3.36736315
16Ependymoma (HP:0002888)3.33158118
17Ureteral duplication (HP:0000073)3.20525182
18Absent forearm bone (HP:0003953)3.10412572
19Aplasia involving forearm bones (HP:0009822)3.10412572
20Abnormality of chromosome stability (HP:0003220)3.05618203
21Abnormality of the preputium (HP:0100587)2.95950236
22Volvulus (HP:0002580)2.95404797
23Abnormality of lateral ventricle (HP:0030047)2.90666580
24Premature ovarian failure (HP:0008209)2.87817125
25Rough bone trabeculation (HP:0100670)2.85778046
26Meckel diverticulum (HP:0002245)2.85400700
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.83464043
28Acute myeloid leukemia (HP:0004808)2.81419943
29Shawl scrotum (HP:0000049)2.80510218
30Hyperglycinuria (HP:0003108)2.80049509
31Abnormality of the ileum (HP:0001549)2.70721724
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.69372330
33Overlapping toe (HP:0001845)2.65151416
34Muscle fiber splitting (HP:0003555)2.59531825
35Multiple enchondromatosis (HP:0005701)2.57825268
36Sparse lateral eyebrow (HP:0005338)2.57763238
37Secondary amenorrhea (HP:0000869)2.57372129
38Subaortic stenosis (HP:0001682)2.56679668
39Abnormality of the left ventricular outflow tract (HP:0011103)2.56679668
40Abnormality of the anterior horn cell (HP:0006802)2.53280410
41Degeneration of anterior horn cells (HP:0002398)2.53280410
42Increased nuchal translucency (HP:0010880)2.52270358
43Rhabdomyosarcoma (HP:0002859)2.50788506
44Hyperglycemia (HP:0003074)2.49065675
45Horseshoe kidney (HP:0000085)2.48986783
46Cerebral hypomyelination (HP:0006808)2.47429765
47Aplasia/hypoplasia of the humerus (HP:0006507)2.46306616
48Supernumerary spleens (HP:0009799)2.44630537
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43121034
50Prominent nose (HP:0000448)2.40940980
51Type 1 muscle fiber predominance (HP:0003803)2.40210386
52Papillary thyroid carcinoma (HP:0002895)2.39511983
53Ectopic kidney (HP:0000086)2.39319651
54Medulloblastoma (HP:0002885)2.38203339
55Exercise-induced muscle cramps (HP:0003710)2.37179659
56Absent thumb (HP:0009777)2.34702144
57Oligodactyly (hands) (HP:0001180)2.34508609
58Oligodactyly (HP:0012165)2.32298382
59Capillary hemangiomas (HP:0005306)2.31940266
60Pelvic girdle muscle weakness (HP:0003749)2.31582822
61Abnormal trabecular bone morphology (HP:0100671)2.29672764
62Dysmetric saccades (HP:0000641)2.28414710
63Biliary tract neoplasm (HP:0100574)2.28132608
64Areflexia of lower limbs (HP:0002522)2.24906155
65Rib fusion (HP:0000902)2.24633950
66Male infertility (HP:0003251)2.24396695
67Neoplasm of the oral cavity (HP:0100649)2.24267423
68Oral leukoplakia (HP:0002745)2.20681150
69Myelodysplasia (HP:0002863)2.19423510
70Short humerus (HP:0005792)2.17748930
71Deep philtrum (HP:0002002)2.17459382
72Breast aplasia (HP:0100783)2.16631111
73Neoplasm of the small intestine (HP:0100833)2.15230129
74Astrocytoma (HP:0009592)2.13780322
75Abnormality of the astrocytes (HP:0100707)2.13780322
76Sloping forehead (HP:0000340)2.13423913
77Aplasia/Hypoplasia of the sternum (HP:0006714)2.12851625
78Abnormality of serine family amino acid metabolism (HP:0010894)2.09896638
79Abnormality of glycine metabolism (HP:0010895)2.09896638
80Abnormality of the nasal septum (HP:0000419)2.08715888
81Entropion (HP:0000621)2.08693168
82Duodenal stenosis (HP:0100867)2.08309643
83Small intestinal stenosis (HP:0012848)2.08309643
84Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07639045
85Abnormal number of incisors (HP:0011064)2.07265215
86Embryonal renal neoplasm (HP:0011794)2.05408547
87Cutaneous melanoma (HP:0012056)2.04835219
88Neoplasm of the rectum (HP:0100743)2.04727182
89Calcaneovalgus deformity (HP:0001848)2.04361253
90Short thumb (HP:0009778)2.03558653
91Squamous cell carcinoma (HP:0002860)2.03364195
92Nephroblastoma (Wilms tumor) (HP:0002667)2.03153905
93Homocystinuria (HP:0002156)2.02883454
94Abnormality of homocysteine metabolism (HP:0010919)2.02883454
95Atresia of the external auditory canal (HP:0000413)2.02484005
96Abnormality of methionine metabolism (HP:0010901)2.02355675
97Reticulocytopenia (HP:0001896)2.01038231
98Shoulder girdle muscle weakness (HP:0003547)2.00325510
99Deformed tarsal bones (HP:0008119)1.95854929
100Adrenal hypoplasia (HP:0000835)1.94875470
101Abnormal biliary tract morphology (HP:0012440)1.94639813
102Abnormality of the carotid arteries (HP:0005344)1.93802286
103Aplasia/Hypoplasia of the breasts (HP:0010311)1.93761698
104Difficulty climbing stairs (HP:0003551)1.93286625
105Neoplasm of striated muscle (HP:0009728)1.92369909
106Glioma (HP:0009733)1.91629549
107Rectal fistula (HP:0100590)1.89074424
108Rectovaginal fistula (HP:0000143)1.89074424
109Cafe-au-lait spot (HP:0000957)1.88906486
110Proximal placement of thumb (HP:0009623)1.88679837
111Abnormal spermatogenesis (HP:0008669)1.88132883
112Abnormality of the musculature of the pelvis (HP:0001469)1.86637731
113Abnormality of the hip-girdle musculature (HP:0001445)1.86637731
114Trismus (HP:0000211)1.86369799
115Abnormality of serum amino acid levels (HP:0003112)1.85595814
116Septate vagina (HP:0001153)1.85160229
117Neoplasm of the pancreas (HP:0002894)1.84421997
118Neoplasm of the colon (HP:0100273)1.84405587
119Exercise-induced myalgia (HP:0003738)1.84385879
120Deviation of the thumb (HP:0009603)1.82220966
121Bone marrow hypocellularity (HP:0005528)1.81371076
122Right ventricular cardiomyopathy (HP:0011663)1.81267531
123Microtia (HP:0008551)1.80463544
124Abnormality of DNA repair (HP:0003254)1.80383197
125Macrocytic anemia (HP:0001972)1.79364766
126Ankyloglossia (HP:0010296)1.78769202
127Hypochromic microcytic anemia (HP:0004840)1.77144018
128Intestinal fistula (HP:0100819)1.74696443
129Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74436844
130Progressive muscle weakness (HP:0003323)1.73584223
131Small epiphyses (HP:0010585)1.73097911
132Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72877036
133Short 1st metacarpal (HP:0010034)1.72877036
134Cystic hygroma (HP:0000476)1.72624855
135Selective tooth agenesis (HP:0001592)1.72395731
136Sensory axonal neuropathy (HP:0003390)1.70423785
137Gout (HP:0001997)1.70170726
138Thyroid carcinoma (HP:0002890)1.69157518
139Abnormality of the duodenum (HP:0002246)1.68684272
140Submucous cleft hard palate (HP:0000176)1.68057679
141Vertebral arch anomaly (HP:0008438)1.68001235
142Narrow face (HP:0000275)1.67886611
143Missing ribs (HP:0000921)1.67078520
144Abnormal auditory evoked potentials (HP:0006958)1.66702166
145Arteriovenous malformation (HP:0100026)1.65755375
146Menstrual irregularities (HP:0000858)1.65677128
147Pseudobulbar signs (HP:0002200)1.64868431
148Low anterior hairline (HP:0000294)1.64618029
149Choanal atresia (HP:0000453)1.64385762
150Cubitus valgus (HP:0002967)1.64310130
151Wide intermamillary distance (HP:0006610)1.63696676
152Hyperkalemia (HP:0002153)1.63328107
153Calf muscle hypertrophy (HP:0008981)1.62651776
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61476740
155Abnormality of alanine metabolism (HP:0010916)1.61476740
156Hyperalaninemia (HP:0003348)1.61476740
157Asymmetry of the thorax (HP:0001555)1.61066199
158Muscle hypertrophy of the lower extremities (HP:0008968)1.60343323
159Short middle phalanx of the 5th finger (HP:0004220)1.59878102
160Abnormal finger flexion creases (HP:0006143)1.59724903
161Enlarged kidneys (HP:0000105)1.59644347
162Short chin (HP:0000331)1.58957721
163Clubbing of toes (HP:0100760)1.58327407
164Distal arthrogryposis (HP:0005684)1.57392250
165Abnormality of the umbilical cord (HP:0010881)1.56544900
166Proximal amyotrophy (HP:0007126)1.56008595
167Breast carcinoma (HP:0003002)1.56008319
168Abnormal lung lobation (HP:0002101)1.55716753
169Long clavicles (HP:0000890)1.55324851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.56216360
2CDK123.54960623
3CDC73.51756168
4NEK23.35970627
5MST43.19910006
6LATS13.02613751
7TTK2.94972097
8STK38L2.94095690
9BUB12.89357413
10LATS22.73410917
11PLK42.57701965
12EIF2AK12.41856726
13SRPK12.35632761
14BRSK22.26857272
15CHEK22.20858559
16PNCK2.19412950
17PLK12.18577208
18AKT32.08816185
19PBK2.08495983
20STK32.04841816
21SCYL21.97545659
22EEF2K1.92604531
23PLK31.90102650
24TAF11.89501734
25MKNK21.86725021
26NEK11.80894324
27NME21.75620831
28CDK71.74639581
29ACVR1B1.73998828
30EPHA21.71917617
31DYRK31.62799694
32AURKB1.59461508
33EIF2AK31.55600184
34MAP3K91.55223569
35PDK31.53692614
36PDK41.53692614
37CHEK11.51497816
38TSSK61.47035272
39MST1R1.43232340
40TTN1.40926026
41TRPM71.37698678
42CDK41.35975834
43CDK81.27595705
44CAMK1G1.21810229
45RPS6KA41.21756069
46MAP3K61.21471929
47BRAF1.19864628
48ATR1.18752917
49MKNK11.18175112
50MELK1.17435617
51ALK1.16294012
52BRSK11.15977772
53ATM1.13133495
54CDK21.04397046
55AURKA1.04372416
56PDK21.03339675
57CLK11.02010573
58TAOK11.00183809
59MAP3K80.90130982
60CSNK1E0.89848943
61STK390.89779138
62CAMK1D0.89290102
63FRK0.88530030
64PIM10.88284145
65ERBB40.85730949
66MTOR0.84660691
67MET0.82171214
68MARK30.82144526
69STK40.78664229
70PRKCI0.78322588
71BRD40.78254493
72STK380.78080583
73WNK40.77933570
74IRAK30.75677209
75RPS6KB20.75151766
76STK100.73376438
77CDK10.73297889
78CSNK2A20.73053179
79WNK10.71629928
80STK160.70817015
81TNIK0.70493611
82MAP3K50.69720269
83FLT30.69289117
84CDK60.67626355
85NUAK10.67434673
86STK240.66969083
87PASK0.65576046
88PIK3CG0.63487116
89NME10.62262317
90PHKG20.59559717
91PHKG10.59559717
92VRK10.58240130
93PRKAA10.57804579
94MAPKAPK50.57130819
95NEK90.56822606
96CSNK2A10.55246546
97PDGFRA0.54377134
98ZAK0.54123247
99NLK0.52918163
100RAF10.52472651
101ERBB30.52067056
102FGFR10.51809099
103CDK30.51509491
104SMG10.51156014
105WNK30.50494437
106BMPR1B0.50446740
107MAPK100.50020895
108TEC0.50012479
109RPS6KB10.45942541
110OBSCN0.45864224
111PAK20.45836308
112MAP3K100.44802534
113PKN20.44650935
114TYRO30.44411793
115AKT20.43921292
116MAPK140.43579976
117PINK10.42982745
118CSNK1D0.42501833
119MUSK0.40664578
120EIF2AK20.38257843
121MAPK110.37691348
122RPS6KA50.37605836
123CCNB10.36619609
124PAK10.36526485
125GSK3B0.36395765
126PRKDC0.35438707
127MAP3K30.34117624
128DMPK0.31558233
129TAOK30.28086231
130DYRK20.28081710
131PRKD30.27128836
132CDK90.25416492
133MAPK10.25016457
134ABL20.24804701
135MAPKAPK30.21675029
136AKT10.21197992
137CSNK1A10.18350854
138RPS6KA10.17164422

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.92619304
2Vitamin B6 metabolism_Homo sapiens_hsa007504.29013802
3RNA polymerase_Homo sapiens_hsa030204.24467643
4RNA transport_Homo sapiens_hsa030134.17488636
5Basal transcription factors_Homo sapiens_hsa030223.33070104
6Mismatch repair_Homo sapiens_hsa034303.20698692
7Cell cycle_Homo sapiens_hsa041103.16852757
8Spliceosome_Homo sapiens_hsa030402.95554385
9DNA replication_Homo sapiens_hsa030302.94609750
10Homologous recombination_Homo sapiens_hsa034402.58479866
11mRNA surveillance pathway_Homo sapiens_hsa030152.43719578
12Fanconi anemia pathway_Homo sapiens_hsa034602.35374307
13Nucleotide excision repair_Homo sapiens_hsa034202.31355297
14RNA degradation_Homo sapiens_hsa030182.27512590
15Proteasome_Homo sapiens_hsa030502.27104964
16Pyrimidine metabolism_Homo sapiens_hsa002402.17812474
17Base excision repair_Homo sapiens_hsa034102.15655975
18p53 signaling pathway_Homo sapiens_hsa041151.87984792
19One carbon pool by folate_Homo sapiens_hsa006701.86957054
20Protein export_Homo sapiens_hsa030601.83529764
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78426128
22Pyruvate metabolism_Homo sapiens_hsa006201.73736151
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72080541
24Non-homologous end-joining_Homo sapiens_hsa034501.66274275
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.61312477
26Ribosome_Homo sapiens_hsa030101.58615590
27Oocyte meiosis_Homo sapiens_hsa041141.47719334
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38054579
29Purine metabolism_Homo sapiens_hsa002301.33642522
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20574085
31Epstein-Barr virus infection_Homo sapiens_hsa051691.17336293
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.16638527
33Regulation of autophagy_Homo sapiens_hsa041401.12626187
34Propanoate metabolism_Homo sapiens_hsa006401.08294228
35mTOR signaling pathway_Homo sapiens_hsa041501.06111549
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98901116
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98484264
38Folate biosynthesis_Homo sapiens_hsa007900.92718780
39Herpes simplex infection_Homo sapiens_hsa051680.90499564
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90254344
41Biosynthesis of amino acids_Homo sapiens_hsa012300.86331436
42MicroRNAs in cancer_Homo sapiens_hsa052060.83243260
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77732575
44Sulfur metabolism_Homo sapiens_hsa009200.77663586
45Selenocompound metabolism_Homo sapiens_hsa004500.77399235
46Thyroid cancer_Homo sapiens_hsa052160.76286135
47TGF-beta signaling pathway_Homo sapiens_hsa043500.75435528
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72701454
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69298212
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68978073
51Pentose phosphate pathway_Homo sapiens_hsa000300.68828648
52Viral carcinogenesis_Homo sapiens_hsa052030.68249535
53N-Glycan biosynthesis_Homo sapiens_hsa005100.66149230
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.64951773
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64675867
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.64403027
57Chronic myeloid leukemia_Homo sapiens_hsa052200.62851722
58Hippo signaling pathway_Homo sapiens_hsa043900.62499649
59Linoleic acid metabolism_Homo sapiens_hsa005910.60950359
60Pancreatic cancer_Homo sapiens_hsa052120.60072342
61Circadian rhythm_Homo sapiens_hsa047100.59389683
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58506878
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54855319
64FoxO signaling pathway_Homo sapiens_hsa040680.54272855
65Proteoglycans in cancer_Homo sapiens_hsa052050.51435058
66Arginine biosynthesis_Homo sapiens_hsa002200.49231468
67Small cell lung cancer_Homo sapiens_hsa052220.48736917
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48577482
69Fructose and mannose metabolism_Homo sapiens_hsa000510.48151987
70Arginine and proline metabolism_Homo sapiens_hsa003300.48088312
71Prostate cancer_Homo sapiens_hsa052150.47526648
72HTLV-I infection_Homo sapiens_hsa051660.46552859
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46494208
74ECM-receptor interaction_Homo sapiens_hsa045120.46000635
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.43377260
76Adherens junction_Homo sapiens_hsa045200.42806268
77Dilated cardiomyopathy_Homo sapiens_hsa054140.42566621
78Dorso-ventral axis formation_Homo sapiens_hsa043200.40897727
79Parkinsons disease_Homo sapiens_hsa050120.40539545
80Antigen processing and presentation_Homo sapiens_hsa046120.40491154
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39838327
82Cardiac muscle contraction_Homo sapiens_hsa042600.39169214
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38725765
84Tight junction_Homo sapiens_hsa045300.38581814
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38138705
86Renal cell carcinoma_Homo sapiens_hsa052110.37904648
87Oxidative phosphorylation_Homo sapiens_hsa001900.35934581
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35672762
89AMPK signaling pathway_Homo sapiens_hsa041520.35203745
90Focal adhesion_Homo sapiens_hsa045100.34612522
91Insulin resistance_Homo sapiens_hsa049310.34064161
92Carbon metabolism_Homo sapiens_hsa012000.33620969
93Endometrial cancer_Homo sapiens_hsa052130.33000497
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32444425
95Glioma_Homo sapiens_hsa052140.32012991
96Systemic lupus erythematosus_Homo sapiens_hsa053220.31157835
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30815045
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29742144
99Fatty acid metabolism_Homo sapiens_hsa012120.29486053
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29140193
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28003281
102Sulfur relay system_Homo sapiens_hsa041220.27962647
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27719512
104Fatty acid elongation_Homo sapiens_hsa000620.27560348
105Glutathione metabolism_Homo sapiens_hsa004800.27115950
106HIF-1 signaling pathway_Homo sapiens_hsa040660.25704054
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23242500
108Melanoma_Homo sapiens_hsa052180.22584446
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.22495955
110Huntingtons disease_Homo sapiens_hsa050160.22446361
111Glucagon signaling pathway_Homo sapiens_hsa049220.21431580
112Hedgehog signaling pathway_Homo sapiens_hsa043400.21214982
113Vitamin digestion and absorption_Homo sapiens_hsa049770.19371367
114Metabolic pathways_Homo sapiens_hsa011000.16790556
115Wnt signaling pathway_Homo sapiens_hsa043100.16657223
116Bladder cancer_Homo sapiens_hsa052190.15429045
117Lysine degradation_Homo sapiens_hsa003100.14777832
118Arachidonic acid metabolism_Homo sapiens_hsa005900.14570717
119Inositol phosphate metabolism_Homo sapiens_hsa005620.14545438
120Pathways in cancer_Homo sapiens_hsa052000.13183142
121Colorectal cancer_Homo sapiens_hsa052100.12662753
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12336226
123Insulin signaling pathway_Homo sapiens_hsa049100.10635815
124Choline metabolism in cancer_Homo sapiens_hsa052310.10068182
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09754999
126Basal cell carcinoma_Homo sapiens_hsa052170.09097038
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.08079455
128Ether lipid metabolism_Homo sapiens_hsa005650.07779082
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.06733840
130Non-small cell lung cancer_Homo sapiens_hsa052230.04950867

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