DNAJC24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH4 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.20416435
2axon ensheathment in central nervous system (GO:0032291)8.20416435
3signal peptide processing (GO:0006465)5.43808419
4fatty acid elongation (GO:0030497)5.24234052
5response to pheromone (GO:0019236)4.59436409
6GPI anchor biosynthetic process (GO:0006506)4.55286556
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.52415516
8chaperone-mediated protein transport (GO:0072321)4.47976311
9myelination (GO:0042552)4.42392031
10ensheathment of neurons (GO:0007272)4.40401160
11axon ensheathment (GO:0008366)4.40401160
12proteasome assembly (GO:0043248)4.33060331
13preassembly of GPI anchor in ER membrane (GO:0016254)4.29710118
14mannosylation (GO:0097502)4.26922418
15protein neddylation (GO:0045116)4.24990858
16nucleotide transmembrane transport (GO:1901679)4.24412432
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23801082
18cholesterol biosynthetic process (GO:0006695)4.11277038
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09630597
20cotranslational protein targeting to membrane (GO:0006613)4.08294697
21regulation of glucokinase activity (GO:0033131)4.02022598
22regulation of hexokinase activity (GO:1903299)4.02022598
23GPI anchor metabolic process (GO:0006505)4.01752215
24cellular ketone body metabolic process (GO:0046950)4.00626324
25protein targeting to ER (GO:0045047)4.00577113
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00009906
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96251282
28ATP synthesis coupled proton transport (GO:0015986)3.96251282
29protein localization to endoplasmic reticulum (GO:0070972)3.92174954
30response to redox state (GO:0051775)3.91116967
31ribosomal small subunit biogenesis (GO:0042274)3.88535796
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.85269866
33protein maturation by protein folding (GO:0022417)3.83367226
34water-soluble vitamin biosynthetic process (GO:0042364)3.74682091
35transcription elongation from RNA polymerase III promoter (GO:0006385)3.71603773
36termination of RNA polymerase III transcription (GO:0006386)3.71603773
37DNA deamination (GO:0045006)3.71386161
38GDP-mannose metabolic process (GO:0019673)3.69647382
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.68354835
40NADH dehydrogenase complex assembly (GO:0010257)3.68354835
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68354835
42protein complex biogenesis (GO:0070271)3.65220196
43sterol biosynthetic process (GO:0016126)3.64990540
44ketone body metabolic process (GO:1902224)3.62173907
45behavioral response to nicotine (GO:0035095)3.58402257
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.55985553
47amino acid salvage (GO:0043102)3.49152356
48L-methionine salvage (GO:0071267)3.49152356
49L-methionine biosynthetic process (GO:0071265)3.49152356
50DNA double-strand break processing (GO:0000729)3.47590837
51replication fork processing (GO:0031297)3.47078468
52respiratory electron transport chain (GO:0022904)3.45305543
53long-chain fatty acid biosynthetic process (GO:0042759)3.41960889
54nonmotile primary cilium assembly (GO:0035058)3.41915842
55isoprenoid biosynthetic process (GO:0008299)3.40414721
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38984012
57electron transport chain (GO:0022900)3.36551862
58mitochondrial respiratory chain complex assembly (GO:0033108)3.34730151
597-methylguanosine mRNA capping (GO:0006370)3.32711398
607-methylguanosine RNA capping (GO:0009452)3.29015628
61RNA capping (GO:0036260)3.29015628
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.28007520
63fucose catabolic process (GO:0019317)3.25865564
64L-fucose metabolic process (GO:0042354)3.25865564
65L-fucose catabolic process (GO:0042355)3.25865564
66substantia nigra development (GO:0021762)3.22996384
67cullin deneddylation (GO:0010388)3.22850176
68cytochrome complex assembly (GO:0017004)3.22742157
69C-terminal protein lipidation (GO:0006501)3.22574405
70magnesium ion transport (GO:0015693)3.20931907
71viral transcription (GO:0019083)3.15906746
72dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.11734411
73protein K6-linked ubiquitination (GO:0085020)3.10954645
74prenylation (GO:0097354)3.08704009
75protein prenylation (GO:0018342)3.08704009
76translation (GO:0006412)3.07823799
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07432919
78epithelial cilium movement (GO:0003351)3.05957569
79translational termination (GO:0006415)3.05348094
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04383012
81recombinational repair (GO:0000725)3.03649300
82oligodendrocyte differentiation (GO:0048709)3.03326572
83creatine metabolic process (GO:0006600)3.03277545
84kidney morphogenesis (GO:0060993)3.03156040
85double-strand break repair via homologous recombination (GO:0000724)3.02503595
86protein K11-linked deubiquitination (GO:0035871)3.02173271
87endocrine pancreas development (GO:0031018)3.00913636
88protein targeting to mitochondrion (GO:0006626)3.00757129
89negative regulation of neurotransmitter secretion (GO:0046929)3.00675353
90platelet dense granule organization (GO:0060155)3.00532802
91positive regulation of cellular amine metabolic process (GO:0033240)2.99763197
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.99695062
93retinal cone cell development (GO:0046549)2.98517329
94amyloid precursor protein metabolic process (GO:0042982)2.97537663
95cranial nerve development (GO:0021545)2.97314415
96negative regulation of ligase activity (GO:0051352)2.96539571
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96539571
98regulation of mitochondrial translation (GO:0070129)2.95726149
99respiratory chain complex IV assembly (GO:0008535)2.93856155
100centriole replication (GO:0007099)2.93817791
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.92494789
102neural tube formation (GO:0001841)2.90920712
103ribosomal large subunit biogenesis (GO:0042273)2.90511035
104nucleoside diphosphate catabolic process (GO:0009134)2.89392728
105deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87661417
106protein deneddylation (GO:0000338)2.87464357
107glandular epithelial cell differentiation (GO:0002067)2.85503723
108regulation of cellular amino acid metabolic process (GO:0006521)2.85146258
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84983126
110establishment of protein localization to mitochondrion (GO:0072655)2.81517401
111axoneme assembly (GO:0035082)2.79804546
112synapsis (GO:0007129)2.79459900
113cilium organization (GO:0044782)2.78606395
114ribosomal small subunit assembly (GO:0000028)2.77730523
115cilium morphogenesis (GO:0060271)2.77551636
116inositol phosphate catabolic process (GO:0071545)2.77322584
117regulation of telomere maintenance (GO:0032204)2.75161593
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74352311
119establishment of protein localization to Golgi (GO:0072600)2.73843725
120detection of light stimulus involved in sensory perception (GO:0050962)2.73839748
121detection of light stimulus involved in visual perception (GO:0050908)2.73839748
122establishment of integrated proviral latency (GO:0075713)2.72699990
123cilium assembly (GO:0042384)2.72651107
124photoreceptor cell maintenance (GO:0045494)2.71289962
125protein localization to cilium (GO:0061512)2.70890822
126maturation of SSU-rRNA (GO:0030490)2.70398491
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.69273670
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67988466
129indolalkylamine metabolic process (GO:0006586)2.67901941
130establishment of viral latency (GO:0019043)2.67673167
131regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67538020
132GTP biosynthetic process (GO:0006183)2.67524760
133protein targeting to membrane (GO:0006612)2.66474529
134regulation of collateral sprouting (GO:0048670)2.66121879
135piRNA metabolic process (GO:0034587)2.66061032
136antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65885505
137reciprocal DNA recombination (GO:0035825)2.63692125
138reciprocal meiotic recombination (GO:0007131)2.63692125
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.63522672
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.63522672
141protein palmitoylation (GO:0018345)2.62986912
142kynurenine metabolic process (GO:0070189)2.62622006
143astrocyte development (GO:0014002)2.62621543
144signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62586891
145signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62586891
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62586891
147nucleotide transport (GO:0006862)2.62518769
148indole-containing compound catabolic process (GO:0042436)2.62511261
149indolalkylamine catabolic process (GO:0046218)2.62511261
150tryptophan catabolic process (GO:0006569)2.62511261
151maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61498016
152polyol catabolic process (GO:0046174)2.59696228
153negative regulation of telomere maintenance (GO:0032205)2.59160742
154rRNA methylation (GO:0031167)2.58474110
155inositol phosphate dephosphorylation (GO:0046855)2.56604108
156phosphorylated carbohydrate dephosphorylation (GO:0046838)2.56604108
157intraciliary transport (GO:0042073)2.54800540
158reflex (GO:0060004)2.53635969
159proline transport (GO:0015824)2.53256581
160protein targeting to Golgi (GO:0000042)2.52511138
161maturation of 5.8S rRNA (GO:0000460)2.51280762
162cilium movement (GO:0003341)2.51119699
163dopamine transport (GO:0015872)2.50447573
164tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.47524918
165RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.47524918
166rRNA modification (GO:0000154)2.46592203
167negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45570632
168somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42604068
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.42604068
170regulation of mitotic spindle checkpoint (GO:1903504)2.41286515
171regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.41286515
172regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40933945
173regulation of meiosis I (GO:0060631)2.38880768
174protein localization to Golgi apparatus (GO:0034067)2.38605899
175positive regulation of glycolytic process (GO:0045821)2.37319886
176methionine biosynthetic process (GO:0009086)2.36921800
177RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.36742572
178nephron epithelium morphogenesis (GO:0072088)2.36561547
179nephron tubule morphogenesis (GO:0072078)2.36561547
180regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.36262054
181neuron fate determination (GO:0048664)2.36042717
182resolution of meiotic recombination intermediates (GO:0000712)2.35881477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.40628455
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.29521027
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.94308762
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.26249295
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.19439211
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.17248261
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75859101
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.66853368
9PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.60647595
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.55867367
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.50657302
12ZNF274_21170338_ChIP-Seq_K562_Hela3.40897008
13ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29565504
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23210488
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21255215
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17697760
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01360968
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.85997635
19GBX2_23144817_ChIP-Seq_PC3_Human2.84324047
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.82089311
21VDR_23849224_ChIP-Seq_CD4+_Human2.65286362
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.61143017
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59949691
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.55695424
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.49068475
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46125286
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43774537
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.38238483
29IGF1R_20145208_ChIP-Seq_DFB_Human2.37162336
30TAF15_26573619_Chip-Seq_HEK293_Human2.35626343
31EWS_26573619_Chip-Seq_HEK293_Human2.30866314
32* FUS_26573619_Chip-Seq_HEK293_Human2.27672293
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20300074
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20076498
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.19041598
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18339142
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15143161
38ELK1_19687146_ChIP-ChIP_HELA_Human2.14831965
39* P300_19829295_ChIP-Seq_ESCs_Human2.14148871
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13712054
41MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12918172
42DCP1A_22483619_ChIP-Seq_HELA_Human2.09531695
43PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00682045
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96208731
45XRN2_22483619_ChIP-Seq_HELA_Human1.93801261
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93510137
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91427396
48* FOXP3_21729870_ChIP-Seq_TREG_Human1.91221376
49ER_23166858_ChIP-Seq_MCF-7_Human1.88467902
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83087490
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82045967
52GABP_19822575_ChIP-Seq_HepG2_Human1.81994866
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.77200773
54TTF2_22483619_ChIP-Seq_HELA_Human1.65681302
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.64504828
56* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63160626
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62511990
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61533854
59SMAD4_21799915_ChIP-Seq_A2780_Human1.59976262
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59324457
61VDR_22108803_ChIP-Seq_LS180_Human1.59182963
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.58488003
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57729372
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.57703882
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56271684
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56011352
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55449435
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53506221
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.52759832
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52726056
71* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49757794
72IRF1_19129219_ChIP-ChIP_H3396_Human1.49732682
73STAT3_23295773_ChIP-Seq_U87_Human1.49665326
74BCAT_22108803_ChIP-Seq_LS180_Human1.49414299
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45971539
76AR_25329375_ChIP-Seq_VCAP_Human1.45199701
77CBP_20019798_ChIP-Seq_JUKART_Human1.43415697
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43415697
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43069548
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.41106814
81TP53_22573176_ChIP-Seq_HFKS_Human1.38419038
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.38316513
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36644524
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.35065215
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34922474
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34071155
87* NANOG_18555785_Chip-Seq_ESCs_Mouse1.33690878
88TCF4_23295773_ChIP-Seq_U87_Human1.33641238
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31998890
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31376062
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30881815
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30473508
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.29522327
94* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29170603
95TCF4_22108803_ChIP-Seq_LS180_Human1.29144432
96* SOX2_19829295_ChIP-Seq_ESCs_Human1.29102829
97* NANOG_19829295_ChIP-Seq_ESCs_Human1.29102829
98* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26124220
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25831105
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.24832892
101YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24465993
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24283070
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23315905
104* P53_22387025_ChIP-Seq_ESCs_Mouse1.22545251
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21184164
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21184164
107* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20598844
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20099038
109ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19325023
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18616182
111TFEB_21752829_ChIP-Seq_HELA_Human1.17173392
112EZH2_22144423_ChIP-Seq_EOC_Human1.15941710
113* E2F1_18555785_Chip-Seq_ESCs_Mouse1.15454355
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14580650
115* STAT3_18555785_Chip-Seq_ESCs_Mouse1.12911327
116* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12856493
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10759722
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.10759722
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10650300
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10431133
121RUNX2_22187159_ChIP-Seq_PCA_Human1.10390515
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10170117
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.08870748
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08548314
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08326919
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07933345
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07617787
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07166317
129CDX2_22108803_ChIP-Seq_LS180_Human1.07154040
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.06626764
131* P300_18555785_Chip-Seq_ESCs_Mouse1.05802448
132* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05279407
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05080647
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04512959
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04062976
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03538677
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01779862
138* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00884954
139CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99591969
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98890870
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93712737
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92842162
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90308888
144* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89818676
145KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88083003
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86159354
147NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85494466
148FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85227147
149TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84945366
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84564729
151LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81501154
152MYC_18940864_ChIP-ChIP_HL60_Human0.81184692
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81136401
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.80924134
155RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80860267
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80778757
157E2F4_17652178_ChIP-ChIP_JURKAT_Human0.80283570
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.79226402
159* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79196252
160EOMES_21245162_ChIP-Seq_HESCs_Human0.77700584
161KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77374138
162KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77374138
163KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77374138
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.76929216
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76495484
166KDM5A_27292631_Chip-Seq_BREAST_Human0.76350348
167STAT1_20625510_ChIP-Seq_HELA_Human0.76150714
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74904781
169* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.71133122
170REST_19997604_ChIP-ChIP_NEURONS_Mouse0.70558149
171EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69911288
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69503858
173TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.69477375
174CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69381743
175MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.68893852
176GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68611248
177SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68513021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.11864591
2MP0004043_abnormal_pH_regulation3.92542781
3MP0000569_abnormal_digit_pigmentation3.68827512
4MP0003136_yellow_coat_color3.48383260
5MP0008877_abnormal_DNA_methylation3.40282354
6MP0002837_dystrophic_cardiac_calcinosis3.34907358
7MP0001529_abnormal_vocalization3.24658051
8MP0003950_abnormal_plasma_membrane3.16977316
9MP0002102_abnormal_ear_morphology3.10153537
10MP0003806_abnormal_nucleotide_metabolis2.65301661
11MP0005171_absent_coat_pigmentation2.59553657
12MP0003195_calcinosis2.56407715
13MP0005379_endocrine/exocrine_gland_phen2.53586794
14MP0003787_abnormal_imprinting2.48837837
15MP0006072_abnormal_retinal_apoptosis2.38521258
16MP0001485_abnormal_pinna_reflex2.38365813
17MP0000462_abnormal_digestive_system2.32712293
18MP0001905_abnormal_dopamine_level2.26029525
19MP0002938_white_spotting2.25575944
20MP0000566_synostosis2.17087210
21MP0002638_abnormal_pupillary_reflex2.15053717
22MP0003283_abnormal_digestive_organ2.00938285
23MP0001986_abnormal_taste_sensitivity1.97674925
24MP0000427_abnormal_hair_cycle1.86418247
25MP0004142_abnormal_muscle_tone1.84847388
26MP0001984_abnormal_olfaction1.84561524
27MP0009379_abnormal_foot_pigmentation1.84329136
28MP0005409_darkened_coat_color1.81022506
29MP0009046_muscle_twitch1.80781675
30MP0004381_abnormal_hair_follicle1.79142548
31MP0003634_abnormal_glial_cell1.73987281
32MP0003690_abnormal_glial_cell1.71091432
33MP0002693_abnormal_pancreas_physiology1.64997478
34MP0008932_abnormal_embryonic_tissue1.63303992
35MP0002234_abnormal_pharynx_morphology1.61797544
36MP0001346_abnormal_lacrimal_gland1.60272007
37MP0006292_abnormal_olfactory_placode1.59148134
38MP0004885_abnormal_endolymph1.58187832
39MP0010386_abnormal_urinary_bladder1.55938076
40MP0003186_abnormal_redox_activity1.55895869
41MP0008260_abnormal_autophagy1.55185763
42MP0003121_genomic_imprinting1.53572369
43MP0001661_extended_life_span1.51988738
44MP0004145_abnormal_muscle_electrophysio1.48933006
45MP0005408_hypopigmentation1.47700169
46MP0000372_irregular_coat_pigmentation1.47258220
47MP0000013_abnormal_adipose_tissue1.46749086
48MP0009745_abnormal_behavioral_response1.42935477
49MP0003646_muscle_fatigue1.42435482
50MP0005058_abnormal_lysosome_morphology1.38862336
51MP0001944_abnormal_pancreas_morphology1.36593834
52MP0005253_abnormal_eye_physiology1.36349552
53MP0002736_abnormal_nociception_after1.36151443
54MP0004742_abnormal_vestibular_system1.35944370
55MP0000613_abnormal_salivary_gland1.35606790
56MP0004215_abnormal_myocardial_fiber1.34513082
57MP0000678_abnormal_parathyroid_gland1.34503087
58MP0004957_abnormal_blastocyst_morpholog1.34084429
59MP0009697_abnormal_copulation1.33666918
60MP0005174_abnormal_tail_pigmentation1.32974115
61MP0002229_neurodegeneration1.32808507
62MP0006036_abnormal_mitochondrial_physio1.32805685
63MP0001968_abnormal_touch/_nociception1.28001038
64MP0005451_abnormal_body_composition1.26989398
65MP0005551_abnormal_eye_electrophysiolog1.25784991
66MP0004133_heterotaxia1.25366519
67MP0003718_maternal_effect1.25235211
68MP0008872_abnormal_physiological_respon1.24140419
69MP0006276_abnormal_autonomic_nervous1.23769645
70MP0002254_reproductive_system_inflammat1.23750351
71MP0004270_analgesia1.23263027
72MP0005084_abnormal_gallbladder_morpholo1.22124106
73MP0003937_abnormal_limbs/digits/tail_de1.22008694
74MP0003693_abnormal_embryo_hatching1.21666130
75MP0002928_abnormal_bile_duct1.19506102
76MP0003329_amyloid_beta_deposits1.18859102
77MP0001486_abnormal_startle_reflex1.14158421
78MP0003122_maternal_imprinting1.14092269
79MP0005410_abnormal_fertilization1.13649491
80MP0004147_increased_porphyrin_level1.12022687
81MP0008057_abnormal_DNA_replication1.10175905
82MP0001501_abnormal_sleep_pattern1.08949222
83MP0002160_abnormal_reproductive_system1.08538802
84MP0002557_abnormal_social/conspecific_i1.08494027
85MP0000383_abnormal_hair_follicle1.08153156
86MP0000631_abnormal_neuroendocrine_gland1.07631231
87MP0003890_abnormal_embryonic-extraembry1.07181768
88MP0002272_abnormal_nervous_system1.06974254
89MP0002876_abnormal_thyroid_physiology1.06684695
90MP0001929_abnormal_gametogenesis1.05085448
91MP0002572_abnormal_emotion/affect_behav1.03475578
92MP0005075_abnormal_melanosome_morpholog1.03111394
93MP0002095_abnormal_skin_pigmentation1.03045114
94MP0002090_abnormal_vision1.02151460
95MP0003011_delayed_dark_adaptation1.00081538
96MP0002909_abnormal_adrenal_gland1.00026943
97MP0005389_reproductive_system_phenotype0.99447272
98MP0005386_behavior/neurological_phenoty0.99200646
99MP0004924_abnormal_behavior0.99200646
100MP0003698_abnormal_male_reproductive0.97323821
101MP0003137_abnormal_impulse_conducting0.96293498
102MP0008789_abnormal_olfactory_epithelium0.95071114
103MP0005220_abnormal_exocrine_pancreas0.94638445
104MP0008995_early_reproductive_senescence0.93872454
105MP0003786_premature_aging0.93816418
106MP0008775_abnormal_heart_ventricle0.93707835
107MP0008875_abnormal_xenobiotic_pharmacok0.92437094
108MP0000647_abnormal_sebaceous_gland0.91673018
109MP0008058_abnormal_DNA_repair0.91479368
110MP0006035_abnormal_mitochondrial_morpho0.90716001
111MP0002735_abnormal_chemical_nociception0.89433041
112MP0003119_abnormal_digestive_system0.89090139
113MP0005645_abnormal_hypothalamus_physiol0.88870739
114MP0002751_abnormal_autonomic_nervous0.88757409
115MP0002210_abnormal_sex_determination0.88500914
116MP0001324_abnormal_eye_pigmentation0.87017812
117MP0002064_seizures0.86510918
118MP0005195_abnormal_posterior_eye0.86267315
119MP0003938_abnormal_ear_development0.85773127
120MP0005646_abnormal_pituitary_gland0.85493863
121MP0002163_abnormal_gland_morphology0.85456336
122MP0005395_other_phenotype0.85401278
123MP0002067_abnormal_sensory_capabilities0.85006481
124MP0004134_abnormal_chest_morphology0.84153887
125MP0001188_hyperpigmentation0.83715765
126MP0008007_abnormal_cellular_replicative0.81499739
127MP0003252_abnormal_bile_duct0.81497003
128MP0001764_abnormal_homeostasis0.81315539
129MP0009333_abnormal_splenocyte_physiolog0.80839572
130MP0000653_abnormal_sex_gland0.79982396
131MP0001963_abnormal_hearing_physiology0.78776721
132MP0003632_abnormal_nervous_system0.78556423
133MP0002098_abnormal_vibrissa_morphology0.78379992
134MP0001293_anophthalmia0.78010876
135MP0002752_abnormal_somatic_nervous0.76736895
136MP0001502_abnormal_circadian_rhythm0.75521161
137MP0000762_abnormal_tongue_morphology0.75266152
138MP0002877_abnormal_melanocyte_morpholog0.74431453
139MP0005391_vision/eye_phenotype0.74375759
140MP0005636_abnormal_mineral_homeostasis0.74038124
141MP0000465_gastrointestinal_hemorrhage0.72156735
142MP0003880_abnormal_central_pattern0.72119576
143MP0002177_abnormal_outer_ear0.72004195
144MP0010678_abnormal_skin_adnexa0.71863544
145MP0000026_abnormal_inner_ear0.71283931
146MP0000003_abnormal_adipose_tissue0.71085188
147MP0003724_increased_susceptibility_to0.69998619
148MP0000049_abnormal_middle_ear0.69059375
149MP0001299_abnormal_eye_distance/0.67989124
150MP0000955_abnormal_spinal_cord0.66693047
151MP0000015_abnormal_ear_pigmentation0.66557072
152MP0000579_abnormal_nail_morphology0.63535850
153MP0000778_abnormal_nervous_system0.63262668
154MP0010094_abnormal_chromosome_stability0.63213163
155MP0002653_abnormal_ependyma_morphology0.62395620
156MP0009643_abnormal_urine_homeostasis0.62002907

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.26114898
2Cerebral hypomyelination (HP:0006808)4.15668170
3Mitochondrial inheritance (HP:0001427)3.86467211
4Abnormal mitochondria in muscle tissue (HP:0008316)3.77410020
5Parakeratosis (HP:0001036)3.68101877
6Renal Fanconi syndrome (HP:0001994)3.66400928
7True hermaphroditism (HP:0010459)3.62876745
8Increased hepatocellular lipid droplets (HP:0006565)3.61361883
9Acute encephalopathy (HP:0006846)3.50521431
10Abnormality of midbrain morphology (HP:0002418)3.49236139
11Molar tooth sign on MRI (HP:0002419)3.49236139
12Hepatic necrosis (HP:0002605)3.43011493
13Type I transferrin isoform profile (HP:0003642)3.42871274
14Abnormality of the renal cortex (HP:0011035)3.42279757
153-Methylglutaconic aciduria (HP:0003535)3.38549180
16Hepatocellular necrosis (HP:0001404)3.36085156
17Nephronophthisis (HP:0000090)3.30966461
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.30114621
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.30114621
20Lipid accumulation in hepatocytes (HP:0006561)3.28907981
21Progressive macrocephaly (HP:0004481)3.22581803
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.21427441
23Abnormal protein N-linked glycosylation (HP:0012347)3.21427441
24Abnormal protein glycosylation (HP:0012346)3.21427441
25Abnormal glycosylation (HP:0012345)3.21427441
26Increased CSF lactate (HP:0002490)3.19087250
27Split foot (HP:0001839)3.14401069
28Leukodystrophy (HP:0002415)3.08684097
29Increased serum pyruvate (HP:0003542)2.97156359
30Abnormality of glycolysis (HP:0004366)2.97156359
31Abnormality of the renal medulla (HP:0100957)2.95478207
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90419016
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90419016
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.83320256
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78022531
36Congenital stationary night blindness (HP:0007642)2.74988863
37Symptomatic seizures (HP:0011145)2.74648215
38Type II lissencephaly (HP:0007260)2.74054018
39Renal cortical cysts (HP:0000803)2.72354605
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67671164
41Gait imbalance (HP:0002141)2.66960289
42Hyperinsulinemic hypoglycemia (HP:0000825)2.66614765
43Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66190730
44Hypoglycemic seizures (HP:0002173)2.64021370
45CNS hypomyelination (HP:0003429)2.63135931
46Intestinal atresia (HP:0011100)2.61772101
47Aplasia/hypoplasia of the uterus (HP:0008684)2.56992710
48Neurofibrillary tangles (HP:0002185)2.56577391
49Tubular atrophy (HP:0000092)2.55939847
50Abnormality of cells of the erythroid lineage (HP:0012130)2.55250117
51Abnormality of renal resorption (HP:0011038)2.53102723
52Microvesicular hepatic steatosis (HP:0001414)2.52576773
53Increased intramyocellular lipid droplets (HP:0012240)2.50588283
54Nephrogenic diabetes insipidus (HP:0009806)2.49810991
55Ketoacidosis (HP:0001993)2.46615374
56Exertional dyspnea (HP:0002875)2.44823398
57Attenuation of retinal blood vessels (HP:0007843)2.41737130
58Peripheral hypomyelination (HP:0007182)2.40474903
59Respiratory failure (HP:0002878)2.39645703
60Cystic liver disease (HP:0006706)2.38403911
61Stenosis of the external auditory canal (HP:0000402)2.37297631
62Chronic hepatic failure (HP:0100626)2.36196354
63Abnormality of the pons (HP:0007361)2.33101420
64Hyperventilation (HP:0002883)2.31108153
65Hypoglycemic coma (HP:0001325)2.30854791
66Sclerocornea (HP:0000647)2.30450587
67Increased serum lactate (HP:0002151)2.29052300
68Abnormal drinking behavior (HP:0030082)2.28891677
69Polydipsia (HP:0001959)2.28891677
70Abnormality of alanine metabolism (HP:0010916)2.27620430
71Hyperalaninemia (HP:0003348)2.27620430
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27620430
73Abnormal number of erythroid precursors (HP:0012131)2.26739171
74Sensory axonal neuropathy (HP:0003390)2.25251458
75Large for gestational age (HP:0001520)2.24669507
76Hepatosplenomegaly (HP:0001433)2.23876196
77Gaze-evoked nystagmus (HP:0000640)2.23729733
78Postnatal microcephaly (HP:0005484)2.22972312
79Glycosuria (HP:0003076)2.22826442
80Abnormality of urine glucose concentration (HP:0011016)2.22826442
81Spastic paraparesis (HP:0002313)2.22038373
82Retinal dysplasia (HP:0007973)2.20562033
83Exercise intolerance (HP:0003546)2.19654164
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19269381
85Asplenia (HP:0001746)2.19030473
86Alacrima (HP:0000522)2.18256160
87Progressive inability to walk (HP:0002505)2.18101319
88Cerebral edema (HP:0002181)2.18082093
89Hypoplasia of the uterus (HP:0000013)2.17913792
90Bile duct proliferation (HP:0001408)2.16579079
91Abnormal biliary tract physiology (HP:0012439)2.16579079
92Abnormality of the labia minora (HP:0012880)2.15590715
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.15092734
94Hypoplastic pelvis (HP:0008839)2.13237539
95Abolished electroretinogram (ERG) (HP:0000550)2.12828019
96Neuroendocrine neoplasm (HP:0100634)2.12741849
97Congenital hepatic fibrosis (HP:0002612)2.12070951
98Abnormality of aromatic amino acid family metabolism (HP:0004338)2.10432556
99Pendular nystagmus (HP:0012043)2.10012125
100Hypoplasia of the pons (HP:0012110)2.09948225
101Patchy hypopigmentation of hair (HP:0011365)2.09853004
102Furrowed tongue (HP:0000221)2.09441387
103Cerebellar dysplasia (HP:0007033)2.09169437
104Pheochromocytoma (HP:0002666)2.09099665
105Methylmalonic aciduria (HP:0012120)2.08433383
106Aplasia/Hypoplasia of the uvula (HP:0010293)2.07496812
107Congenital, generalized hypertrichosis (HP:0004540)2.07489868
108Medial flaring of the eyebrow (HP:0010747)2.05528947
109Lactic acidosis (HP:0003128)2.04756542
110Abnormal rod and cone electroretinograms (HP:0008323)2.04596598
111Vaginal atresia (HP:0000148)2.04227371
112Progressive neurologic deterioration (HP:0002344)2.03635326
113Increased muscle lipid content (HP:0009058)2.02320687
114Pancreatic fibrosis (HP:0100732)2.01303638
115Anencephaly (HP:0002323)2.01198876
116Pancreatic cysts (HP:0001737)2.00828926
117Hyperphosphaturia (HP:0003109)2.00114228
118Macrocytic anemia (HP:0001972)1.99387841
119Optic disc pallor (HP:0000543)1.98679874
120Generalized aminoaciduria (HP:0002909)1.98387778
121Congenital ichthyosiform erythroderma (HP:0007431)1.97940291
122Male pseudohermaphroditism (HP:0000037)1.97467866
123Neoplasm of the adrenal cortex (HP:0100641)1.96848680
124Respiratory difficulties (HP:0002880)1.96572422
125Aplasia/Hypoplasia of the tibia (HP:0005772)1.96043829
126Postaxial foot polydactyly (HP:0001830)1.95586449
127Genital tract atresia (HP:0001827)1.92503981
128Postaxial hand polydactyly (HP:0001162)1.91954982
129Increased corneal curvature (HP:0100692)1.91886432
130Keratoconus (HP:0000563)1.91886432
131Poor coordination (HP:0002370)1.90621024
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.90120441
133Lissencephaly (HP:0001339)1.90094034
134Methylmalonic acidemia (HP:0002912)1.89757748
135Bony spicule pigmentary retinopathy (HP:0007737)1.88160419
136Breast hypoplasia (HP:0003187)1.85926412
137Abnormality of vitamin B metabolism (HP:0004340)1.85327802
138Duplicated collecting system (HP:0000081)1.85313199
139Absent septum pellucidum (HP:0001331)1.85174969
140CNS demyelination (HP:0007305)1.83643653
141Colon cancer (HP:0003003)1.83077694
142Abnormality of the ileum (HP:0001549)1.82190322
143Hypomagnesemia (HP:0002917)1.81982050
144Anteriorly placed anus (HP:0001545)1.81686151
145Abnormal auditory evoked potentials (HP:0006958)1.81108646
146Hyperglycinemia (HP:0002154)1.80931148
147Polyuria (HP:0000103)1.80278082
148White forelock (HP:0002211)1.79599420
149Supernumerary spleens (HP:0009799)1.79517502
150Abnormality of chromosome stability (HP:0003220)1.78769227
151Meckel diverticulum (HP:0002245)1.78534476
152Hypothermia (HP:0002045)1.78047177
153Inability to walk (HP:0002540)1.76998788
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75553508
155Abnormal pupillary function (HP:0007686)1.75344897
156Gastrointestinal atresia (HP:0002589)1.74563750
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74496031
158Cupped ear (HP:0000378)1.74468893
159Increased circulating renin level (HP:0000848)1.74422857
160Disproportionate short-trunk short stature (HP:0003521)1.74397582
161Hemiparesis (HP:0001269)1.73736022
162Ketosis (HP:0001946)1.73233580
163Aplasia/Hypoplasia of the fovea (HP:0008060)1.73050607
164Hypoplasia of the fovea (HP:0007750)1.73050607
165Reticulocytopenia (HP:0001896)1.73037009
166Optic nerve hypoplasia (HP:0000609)1.72922104
167Congenital primary aphakia (HP:0007707)1.72647310
168Abnormality of the renal collecting system (HP:0004742)1.71205864
169Hyperglycinuria (HP:0003108)1.71189447
170Morphological abnormality of the inner ear (HP:0011390)1.71132502
171Aqueductal stenosis (HP:0002410)1.70990746
172Abnormality of endocrine pancreas physiology (HP:0012093)1.70157113
173Calf muscle hypertrophy (HP:0008981)1.68938323
174Tachypnea (HP:0002789)1.68523976
175Abnormality of methionine metabolism (HP:0010901)1.68486231
176Sloping forehead (HP:0000340)1.68231408
177Dandy-Walker malformation (HP:0001305)1.68094289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.01439448
2STK394.07795813
3PBK3.83432123
4STK163.62415903
5MAP4K23.22700221
6EIF2AK32.75821163
7BUB12.65735646
8PASK2.62752193
9OXSR12.56806655
10BCR2.42927304
11MAPK152.42797556
12TNIK2.33207538
13MST42.21616812
14MAP3K42.07996332
15PINK12.07372428
16MKNK22.07140005
17WNK41.97469574
18EIF2AK11.91542514
19BMPR1B1.89919660
20TESK21.84968007
21LIMK11.83555853
22MAPKAPK51.81911421
23STK38L1.79167655
24VRK11.78760729
25ERBB31.68758806
26MET1.62868011
27NME21.61391037
28INSRR1.60764848
29CSNK1G31.52228539
30UHMK11.45901208
31TLK11.43779937
32TRIM281.42455206
33EPHB11.39242900
34IRAK11.39235708
35PAK31.38084623
36PLK31.35313503
37DYRK21.33478460
38ARAF1.33136534
39IRAK31.32401785
40CSNK1A1L1.30845737
41TAOK31.30514753
42PKN11.29237509
43CLK11.27176182
44PLK21.25659699
45CSNK1G11.23369254
46NEK61.23364255
47MKNK11.15221577
48STK31.13136713
49SRPK11.11664291
50NME11.11517627
51CDK191.10350836
52DYRK31.09913733
53WEE11.08233619
54CAMK2B1.07613175
55MAP2K71.06525056
56BRAF1.05005691
57PHKG21.03866850
58PHKG11.03866850
59RPS6KA51.03025309
60IRAK41.00937690
61BRSK21.00356857
62BCKDK1.00046699
63CAMK2D0.99677572
64NLK0.98332522
65IRAK20.95793019
66FER0.94477444
67HIPK20.92591620
68MAP2K20.85986263
69AURKA0.84121701
70PRPF4B0.82439279
71PLK40.80807913
72NEK10.79935959
73CSNK1G20.79731381
74TAF10.76949325
75CAMKK20.73090102
76PTK2B0.72107922
77PRKCG0.71246573
78DAPK20.71232456
79ITK0.70429251
80MUSK0.68715307
81ADRBK10.68173772
82TEC0.67627165
83NTRK30.67366186
84PLK10.67173754
85CAMK2G0.67151311
86ZAK0.66331488
87BRSK10.64069032
88TGFBR10.63632442
89WNK10.62076854
90FGFR20.62036019
91CASK0.59945476
92ROCK20.58507122
93VRK20.58460407
94NTRK10.56486595
95MARK10.55445821
96EPHA40.55394613
97CDC70.53532995
98EIF2AK20.52857806
99NUAK10.50487781
100PIM20.50376030
101ATM0.50346910
102CAMK2A0.49556791
103PNCK0.49433151
104ADRBK20.48560048
105STK240.48313611
106EPHA30.47988726
107OBSCN0.47553081
108PAK10.46571950
109CDK140.45484854
110TSSK60.45436238
111MELK0.44510933
112AKT30.44042749
113PRKAA20.43903435
114GRK70.43785257
115ACVR1B0.43025883
116STK110.42912351
117CSNK2A20.42737892
118WNK30.42630286
119CDK80.42216113
120ABL20.41808480
121TXK0.41571259
122PRKCE0.40608170
123ATR0.40339075
124CSNK1D0.39267602
125CHEK20.39215840
126CSNK2A10.39161112
127BRD40.39131350
128CSNK1A10.39025270
129CDK30.38708335
130TIE10.38637029
131CCNB10.38021402
132MAP2K60.37929152
133PRKAA10.37694951
134NEK20.37556411
135NTRK20.37003785
136TTK0.36181562
137PIK3CG0.36116616
138MAPK130.36049020
139GRK10.35622149
140LATS10.34997935
141BMPR20.34853944
142STK40.34349805
143PRKACA0.34338486
144PRKCQ0.33651905
145CDK11A0.32818355
146CDK70.31745470
147FLT30.31005569
148DYRK1B0.30212924
149CDK150.30045359
150RPS6KB20.29835378
151TRPM70.28699588
152AURKB0.28229113

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.50609313
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.62430684
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.40232847
4Proteasome_Homo sapiens_hsa030503.30724558
5Ribosome_Homo sapiens_hsa030103.25687169
6Oxidative phosphorylation_Homo sapiens_hsa001903.15577024
7RNA polymerase_Homo sapiens_hsa030203.13252080
8Fatty acid elongation_Homo sapiens_hsa000622.92044406
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.89214045
10Sulfur metabolism_Homo sapiens_hsa009202.81160234
11Steroid biosynthesis_Homo sapiens_hsa001002.63531948
12Parkinsons disease_Homo sapiens_hsa050122.51949325
13Folate biosynthesis_Homo sapiens_hsa007902.10450844
14Alzheimers disease_Homo sapiens_hsa050101.92057712
15Huntingtons disease_Homo sapiens_hsa050161.85812896
16Mismatch repair_Homo sapiens_hsa034301.75625793
17Ether lipid metabolism_Homo sapiens_hsa005651.74521144
18DNA replication_Homo sapiens_hsa030301.74213961
19Pyrimidine metabolism_Homo sapiens_hsa002401.71878781
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.66634045
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62074138
22Spliceosome_Homo sapiens_hsa030401.61891823
23Nitrogen metabolism_Homo sapiens_hsa009101.58313634
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55049194
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52720694
26Tryptophan metabolism_Homo sapiens_hsa003801.51932074
27Basal transcription factors_Homo sapiens_hsa030221.49852393
28Homologous recombination_Homo sapiens_hsa034401.42555024
29Sphingolipid metabolism_Homo sapiens_hsa006001.36006899
30Nucleotide excision repair_Homo sapiens_hsa034201.35791636
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31503941
32Nicotine addiction_Homo sapiens_hsa050331.29089813
33Linoleic acid metabolism_Homo sapiens_hsa005911.27677777
34Caffeine metabolism_Homo sapiens_hsa002321.27522861
35Non-homologous end-joining_Homo sapiens_hsa034501.26383741
36Circadian rhythm_Homo sapiens_hsa047101.24411650
37Vibrio cholerae infection_Homo sapiens_hsa051101.19430893
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16147354
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16058465
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.15416942
41Olfactory transduction_Homo sapiens_hsa047401.13814708
42Vitamin B6 metabolism_Homo sapiens_hsa007501.12284802
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10589596
44Purine metabolism_Homo sapiens_hsa002301.07559973
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04667012
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01957970
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98459234
48Base excision repair_Homo sapiens_hsa034100.97336695
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96780228
50RNA degradation_Homo sapiens_hsa030180.96416112
51Taste transduction_Homo sapiens_hsa047420.95795035
52Glutathione metabolism_Homo sapiens_hsa004800.95639704
53N-Glycan biosynthesis_Homo sapiens_hsa005100.94461923
54Sulfur relay system_Homo sapiens_hsa041220.94447959
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94226673
56Histidine metabolism_Homo sapiens_hsa003400.92956174
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90914110
58Arachidonic acid metabolism_Homo sapiens_hsa005900.90626265
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87861682
60RNA transport_Homo sapiens_hsa030130.85301409
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84405454
62Arginine and proline metabolism_Homo sapiens_hsa003300.82887449
63Metabolic pathways_Homo sapiens_hsa011000.81496864
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81090408
65Fanconi anemia pathway_Homo sapiens_hsa034600.80744684
66Regulation of autophagy_Homo sapiens_hsa041400.78350820
67beta-Alanine metabolism_Homo sapiens_hsa004100.76149229
68Butanoate metabolism_Homo sapiens_hsa006500.71466823
69ABC transporters_Homo sapiens_hsa020100.69924104
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69380040
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67998161
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64781256
73Mineral absorption_Homo sapiens_hsa049780.64497702
74Lysosome_Homo sapiens_hsa041420.63910824
75GABAergic synapse_Homo sapiens_hsa047270.63688824
76Morphine addiction_Homo sapiens_hsa050320.62154905
77Retinol metabolism_Homo sapiens_hsa008300.62097437
78Cardiac muscle contraction_Homo sapiens_hsa042600.61856633
79Chemical carcinogenesis_Homo sapiens_hsa052040.61527415
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61281087
81Lysine degradation_Homo sapiens_hsa003100.57897338
82Ovarian steroidogenesis_Homo sapiens_hsa049130.57387139
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.57204231
84Peroxisome_Homo sapiens_hsa041460.56460361
85Oocyte meiosis_Homo sapiens_hsa041140.55781622
86Fatty acid degradation_Homo sapiens_hsa000710.53988905
87Pyruvate metabolism_Homo sapiens_hsa006200.53350280
88Glutamatergic synapse_Homo sapiens_hsa047240.52367241
89Collecting duct acid secretion_Homo sapiens_hsa049660.52291849
90Alcoholism_Homo sapiens_hsa050340.51412327
91Cell cycle_Homo sapiens_hsa041100.51386312
92Systemic lupus erythematosus_Homo sapiens_hsa053220.50302239
93Circadian entrainment_Homo sapiens_hsa047130.49144941
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45373095
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43747098
96Asthma_Homo sapiens_hsa053100.41482960
97Rheumatoid arthritis_Homo sapiens_hsa053230.41156962
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40153135
99Other glycan degradation_Homo sapiens_hsa005110.39377659
100Glycerolipid metabolism_Homo sapiens_hsa005610.38506104
101Tyrosine metabolism_Homo sapiens_hsa003500.36809599
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36158919
103Epstein-Barr virus infection_Homo sapiens_hsa051690.34566556
104TGF-beta signaling pathway_Homo sapiens_hsa043500.33904041
105Dopaminergic synapse_Homo sapiens_hsa047280.30952453
106Serotonergic synapse_Homo sapiens_hsa047260.30950310
107Salivary secretion_Homo sapiens_hsa049700.30859248
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30127406
109Phagosome_Homo sapiens_hsa041450.29722376
110Fatty acid biosynthesis_Homo sapiens_hsa000610.29589098
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29310876
112Selenocompound metabolism_Homo sapiens_hsa004500.28821352
113p53 signaling pathway_Homo sapiens_hsa041150.28361376
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.27301749
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27156208
116Autoimmune thyroid disease_Homo sapiens_hsa053200.25940480
117Hedgehog signaling pathway_Homo sapiens_hsa043400.25552064
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22725656
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.19540718
120Cocaine addiction_Homo sapiens_hsa050300.18237144
121Phototransduction_Homo sapiens_hsa047440.18234573
122One carbon pool by folate_Homo sapiens_hsa006700.18168469
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.16323284
124Pentose phosphate pathway_Homo sapiens_hsa000300.14929613
125Vitamin digestion and absorption_Homo sapiens_hsa049770.14781670
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.14635877
127mRNA surveillance pathway_Homo sapiens_hsa030150.12904651
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11644570
129Type I diabetes mellitus_Homo sapiens_hsa049400.11409307
130Fatty acid metabolism_Homo sapiens_hsa012120.10605268
131Propanoate metabolism_Homo sapiens_hsa006400.10189141
132Insulin secretion_Homo sapiens_hsa049110.10158148
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09576769
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08464095
135Primary immunodeficiency_Homo sapiens_hsa053400.06776084
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06469825
137Fructose and mannose metabolism_Homo sapiens_hsa000510.06451494
138Phenylalanine metabolism_Homo sapiens_hsa003600.05770130
139Renal cell carcinoma_Homo sapiens_hsa052110.05534701

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