DNAJC27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.29943105
2synaptic vesicle maturation (GO:0016188)6.14900386
3locomotory exploration behavior (GO:0035641)5.75342285
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.43558271
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35611247
6synaptic vesicle exocytosis (GO:0016079)5.31560273
7regulation of synaptic vesicle exocytosis (GO:2000300)5.11174474
8vocalization behavior (GO:0071625)5.08381513
9glutamate secretion (GO:0014047)4.98839912
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93214243
11regulation of glutamate receptor signaling pathway (GO:1900449)4.91630411
12neuronal action potential propagation (GO:0019227)4.77334316
13neurotransmitter secretion (GO:0007269)4.76648613
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.69303780
15regulation of synaptic vesicle transport (GO:1902803)4.62869030
16negative regulation of inclusion body assembly (GO:0090084)4.46981156
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.39828312
18protein localization to cilium (GO:0061512)4.39508193
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.39368874
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.38027525
21exploration behavior (GO:0035640)4.32740553
22protein localization to synapse (GO:0035418)4.31676456
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29518955
24cellular potassium ion homeostasis (GO:0030007)4.27985872
25regulation of neuronal synaptic plasticity (GO:0048168)4.25562969
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18166246
27sodium ion export (GO:0071436)4.07521278
28neuron cell-cell adhesion (GO:0007158)4.06523999
29layer formation in cerebral cortex (GO:0021819)4.04232646
30pyrimidine nucleobase catabolic process (GO:0006208)4.00392067
31gamma-aminobutyric acid transport (GO:0015812)4.00274909
32proline transport (GO:0015824)3.99814059
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94934481
34neurotransmitter transport (GO:0006836)3.94205168
35neuromuscular process controlling posture (GO:0050884)3.92277861
36synaptic transmission, glutamatergic (GO:0035249)3.91452813
37regulation of synapse structural plasticity (GO:0051823)3.89200493
38mechanosensory behavior (GO:0007638)3.87299774
39activation of protein kinase A activity (GO:0034199)3.83884974
40cilium movement (GO:0003341)3.83850508
41glutamate receptor signaling pathway (GO:0007215)3.83403299
42long-term memory (GO:0007616)3.83137813
43neuron-neuron synaptic transmission (GO:0007270)3.80329971
44neurotransmitter-gated ion channel clustering (GO:0072578)3.71198027
45cilium or flagellum-dependent cell motility (GO:0001539)3.70147672
46cerebral cortex radially oriented cell migration (GO:0021799)3.69802667
47membrane depolarization during action potential (GO:0086010)3.69711117
48epithelial cilium movement (GO:0003351)3.68659579
49dendritic spine morphogenesis (GO:0060997)3.68574537
50positive regulation of mitochondrial fission (GO:0090141)3.67275884
51central nervous system projection neuron axonogenesis (GO:0021952)3.67077812
52intraciliary transport (GO:0042073)3.66580064
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61498150
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.59278779
55cerebellar Purkinje cell differentiation (GO:0021702)3.57094951
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.56036530
57regulation of neurotransmitter levels (GO:0001505)3.55006725
58positive regulation of membrane potential (GO:0045838)3.54275955
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52428293
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.52224702
61behavioral response to nicotine (GO:0035095)3.52045545
62calcium ion-dependent exocytosis (GO:0017156)3.51644934
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50940920
64brain morphogenesis (GO:0048854)3.45337658
65axoneme assembly (GO:0035082)3.40735451
66regulation of inclusion body assembly (GO:0090083)3.40465665
67neuromuscular process controlling balance (GO:0050885)3.37868434
68positive regulation of neurotransmitter transport (GO:0051590)3.36886750
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36282383
70regulation of postsynaptic membrane potential (GO:0060078)3.36147411
71negative regulation of oligodendrocyte differentiation (GO:0048715)3.35448615
72cell communication by electrical coupling (GO:0010644)3.34505061
73synapsis (GO:0007129)3.34166633
74synaptic vesicle endocytosis (GO:0048488)3.32798881
75regulation of neurotransmitter secretion (GO:0046928)3.32483016
76central nervous system neuron axonogenesis (GO:0021955)3.32438514
77regulation of synaptic plasticity (GO:0048167)3.32416825
78glycine transport (GO:0015816)3.32315470
79positive regulation of synapse maturation (GO:0090129)3.30591895
80transmission of nerve impulse (GO:0019226)3.29260339
81resolution of meiotic recombination intermediates (GO:0000712)3.27418868
82prepulse inhibition (GO:0060134)3.23186540
83piRNA metabolic process (GO:0034587)3.22190425
84presynaptic membrane assembly (GO:0097105)3.22131431
85regulation of neurotransmitter transport (GO:0051588)3.18821709
86vesicle transport along microtubule (GO:0047496)3.18116478
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.18095341
88membrane depolarization (GO:0051899)3.17579394
89neuronal ion channel clustering (GO:0045161)3.16214155
90protein polyglutamylation (GO:0018095)3.14468907
91nucleobase catabolic process (GO:0046113)3.14192478
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13602901
93long-term synaptic potentiation (GO:0060291)3.12875559
94neuron recognition (GO:0008038)3.12200911
95regulation of dendritic spine morphogenesis (GO:0061001)3.10830216
96membrane hyperpolarization (GO:0060081)3.10422667
97histone H2A acetylation (GO:0043968)3.09255998
98positive regulation of potassium ion transmembrane transport (GO:1901381)3.07921168
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07791224
100regulation of ARF protein signal transduction (GO:0032012)3.07770097
101response to histamine (GO:0034776)3.07540361
102retinal cone cell development (GO:0046549)3.06688426
103regulation of glucocorticoid secretion (GO:2000849)3.06405090
104presynaptic membrane organization (GO:0097090)3.06085260
105regulation of vesicle fusion (GO:0031338)3.05869524
106substrate-independent telencephalic tangential migration (GO:0021826)3.05779501
107substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.05779501
108potassium ion import (GO:0010107)3.03975055
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02564094
110regulation of collateral sprouting (GO:0048670)3.00689076
111DNA methylation involved in gamete generation (GO:0043046)2.99066585
112synaptic transmission (GO:0007268)2.98894139
113potassium ion homeostasis (GO:0055075)2.98481353
114cellular sodium ion homeostasis (GO:0006883)2.98120797
115response to auditory stimulus (GO:0010996)2.97913466
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.97578070
117axonal fasciculation (GO:0007413)2.96628129
118nonmotile primary cilium assembly (GO:0035058)2.95004690
119auditory behavior (GO:0031223)2.94517758
120neuromuscular process (GO:0050905)2.93150502
121positive regulation of synaptic transmission (GO:0050806)2.92115274
122striatum development (GO:0021756)2.92023271
123regulation of cilium movement (GO:0003352)2.91792044
124intraspecies interaction between organisms (GO:0051703)2.91657858
125social behavior (GO:0035176)2.91657858
126mating behavior (GO:0007617)2.90673097
127axonemal dynein complex assembly (GO:0070286)2.88738593
128regulation of synaptic transmission (GO:0050804)2.88517820
129cilium organization (GO:0044782)2.88428701
130axon ensheathment in central nervous system (GO:0032291)2.87119751
131central nervous system myelination (GO:0022010)2.87119751
132innervation (GO:0060384)2.87005117
133learning (GO:0007612)2.86779892
134cochlea development (GO:0090102)2.85621656
135behavioral defense response (GO:0002209)2.85107368
136behavioral fear response (GO:0001662)2.85107368
137cilium assembly (GO:0042384)2.84595503
138regulation of synaptic transmission, GABAergic (GO:0032228)2.84000372
139positive regulation of neurotransmitter secretion (GO:0001956)2.83742088
140neuronal stem cell maintenance (GO:0097150)2.74902937
141interkinetic nuclear migration (GO:0022027)2.74265945
142serotonin metabolic process (GO:0042428)2.73713241
143neural tube formation (GO:0001841)2.73148133
144forebrain neuron differentiation (GO:0021879)2.71985239
145neuron fate determination (GO:0048664)2.70651249
146regulation of telomere maintenance (GO:0032204)2.70644147
147regulation of timing of cell differentiation (GO:0048505)2.66523448
148dendritic spine organization (GO:0097061)2.61957571
149negative regulation of telomere maintenance (GO:0032205)2.60649006
150mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.60073596
151positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.60073596
152glycosphingolipid biosynthetic process (GO:0006688)2.59861763
153olfactory bulb development (GO:0021772)2.58886813
154regulation of development, heterochronic (GO:0040034)2.58035912
155cell wall macromolecule catabolic process (GO:0016998)2.54922680
156adult walking behavior (GO:0007628)2.54437065
157primary amino compound metabolic process (GO:1901160)2.53150129
158cilium morphogenesis (GO:0060271)2.49828063
159C4-dicarboxylate transport (GO:0015740)2.46557891
160protein refolding (GO:0042026)2.45412222
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.44429483
162regulation of microtubule-based movement (GO:0060632)2.44189368
163nucleus localization (GO:0051647)2.43720351
164negative regulation of neurotransmitter transport (GO:0051589)2.42691782
165microtubule severing (GO:0051013)2.42597531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.59200003
2REST_21632747_ChIP-Seq_MESCs_Mouse3.03092922
3GBX2_23144817_ChIP-Seq_PC3_Human2.96665242
4* RARB_27405468_Chip-Seq_BRAIN_Mouse2.87621209
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84420079
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73717279
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69228878
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66606827
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.61584819
10DROSHA_22980978_ChIP-Seq_HELA_Human2.56021307
11VDR_22108803_ChIP-Seq_LS180_Human2.49526776
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46147100
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.46117508
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41306337
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39817634
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35357681
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35357681
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.34524782
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26567164
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21363367
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20540829
22FUS_26573619_Chip-Seq_HEK293_Human2.18263391
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16267380
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13949482
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13126651
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12516950
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.12362492
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11473161
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.09686539
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08720980
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06083690
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.05613770
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02828213
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.02403506
35ZNF274_21170338_ChIP-Seq_K562_Hela1.81333030
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.80572585
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.80306192
38EWS_26573619_Chip-Seq_HEK293_Human1.79560154
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75691522
40* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72480850
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69592896
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69592896
43SMAD4_21799915_ChIP-Seq_A2780_Human1.67888118
44AR_21572438_ChIP-Seq_LNCaP_Human1.65848306
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65381739
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.61558476
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59799920
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58873835
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58345942
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55521944
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50895653
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50823345
53TAF15_26573619_Chip-Seq_HEK293_Human1.48522947
54BCAT_22108803_ChIP-Seq_LS180_Human1.44534711
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.42770464
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42487046
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37670200
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37610661
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34802480
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34571595
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.33413806
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32594502
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.31855070
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31624494
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.29136798
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.26429527
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26235221
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25053554
69AR_19668381_ChIP-Seq_PC3_Human1.22951224
70AR_25329375_ChIP-Seq_VCAP_Human1.22215488
71STAT3_23295773_ChIP-Seq_U87_Human1.22137957
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21864701
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20983649
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.19194781
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18469304
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.18369880
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18215216
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18163210
79P300_19829295_ChIP-Seq_ESCs_Human1.16631878
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16571193
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15128057
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14876554
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14473452
84P53_22387025_ChIP-Seq_ESCs_Mouse1.13848568
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.13749482
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13165953
87TCF4_23295773_ChIP-Seq_U87_Human1.12863183
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12633056
89TCF4_22108803_ChIP-Seq_LS180_Human1.11311093
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.11037638
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10708414
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10553869
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10066419
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09907593
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09506212
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09502868
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08829114
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.07953589
99TP53_18474530_ChIP-ChIP_U2OS_Human1.07932803
100SOX2_19829295_ChIP-Seq_ESCs_Human1.07071245
101NANOG_19829295_ChIP-Seq_ESCs_Human1.07071245
102IGF1R_20145208_ChIP-Seq_DFB_Human1.06983058
103SMAD3_21741376_ChIP-Seq_ESCs_Human1.05922606
104KDM2B_26808549_Chip-Seq_K562_Human1.05790829
105RXR_22108803_ChIP-Seq_LS180_Human1.05352642
106IRF1_19129219_ChIP-ChIP_H3396_Human1.05115508
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04857433
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04836678
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.04638138
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.03215863
111* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02498085
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.02355080
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02042955
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01743564
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00407032
116* SOX9_26525672_Chip-Seq_HEART_Mouse1.00333927
117RNF2_27304074_Chip-Seq_NSC_Mouse0.99618258
118TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98925127
119* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98588048
120CBP_20019798_ChIP-Seq_JUKART_Human0.98401796
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98401796
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.95702268
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.95579823
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.95191956
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94694098
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94636168
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93473976
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.93054543
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92943651
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92823360
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92344927
132AHR_22903824_ChIP-Seq_MCF-7_Human0.91248298
133* RUNX2_22187159_ChIP-Seq_PCA_Human0.88904815
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88782851
135KLF4_19829295_ChIP-Seq_ESCs_Human0.86631830
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86296682
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.85869905
138ER_23166858_ChIP-Seq_MCF-7_Human0.85571233
139CTCF_27219007_Chip-Seq_Bcells_Human0.85096166
140* SMAD4_21741376_ChIP-Seq_HESCs_Human0.85031812
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84993520
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84710643
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.83738834
144FLI1_21867929_ChIP-Seq_TH2_Mouse0.83405010
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.82651433
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82522525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07979370
2MP0003880_abnormal_central_pattern4.44677928
3MP0003635_abnormal_synaptic_transmissio4.07188654
4MP0009046_muscle_twitch3.54553789
5MP0001968_abnormal_touch/_nociception3.47473933
6MP0004270_analgesia3.45663908
7MP0009745_abnormal_behavioral_response3.43996141
8MP0002063_abnormal_learning/memory/cond3.18798862
9MP0002064_seizures3.15600417
10MP0005423_abnormal_somatic_nervous2.83917603
11MP0002572_abnormal_emotion/affect_behav2.73333714
12MP0002822_catalepsy2.64095088
13MP0002272_abnormal_nervous_system2.56990301
14MP0002734_abnormal_mechanical_nocicepti2.49417538
15MP0001486_abnormal_startle_reflex2.43811951
16MP0003122_maternal_imprinting2.22761907
17MP0002735_abnormal_chemical_nociception2.21211528
18MP0001501_abnormal_sleep_pattern2.17566891
19MP0002736_abnormal_nociception_after2.05593284
20MP0002067_abnormal_sensory_capabilities2.01544024
21MP0008569_lethality_at_weaning2.00376670
22MP0001440_abnormal_grooming_behavior1.99520309
23MP0002733_abnormal_thermal_nociception1.93833053
24MP0005410_abnormal_fertilization1.85425334
25MP0001970_abnormal_pain_threshold1.83666649
26MP0005386_behavior/neurological_phenoty1.82983142
27MP0004924_abnormal_behavior1.82983142
28MP0004811_abnormal_neuron_physiology1.82438474
29MP0002557_abnormal_social/conspecific_i1.82427014
30MP0002909_abnormal_adrenal_gland1.79922240
31MP0003787_abnormal_imprinting1.79624316
32MP0005646_abnormal_pituitary_gland1.76610319
33MP0002102_abnormal_ear_morphology1.71318904
34MP0004145_abnormal_muscle_electrophysio1.69061825
35MP0002928_abnormal_bile_duct1.67288599
36MP0003329_amyloid_beta_deposits1.66202373
37MP0001984_abnormal_olfaction1.65039648
38MP0009780_abnormal_chondrocyte_physiolo1.64108347
39MP0001986_abnormal_taste_sensitivity1.63933849
40MP0002184_abnormal_innervation1.62434985
41MP0000751_myopathy1.57129313
42MP0006276_abnormal_autonomic_nervous1.54766174
43MP0000955_abnormal_spinal_cord1.47527034
44MP0005645_abnormal_hypothalamus_physiol1.46210953
45MP0005253_abnormal_eye_physiology1.45452812
46MP0006292_abnormal_olfactory_placode1.44916445
47MP0004885_abnormal_endolymph1.40618807
48MP0002066_abnormal_motor_capabilities/c1.40256192
49MP0003633_abnormal_nervous_system1.35102681
50MP0004858_abnormal_nervous_system1.35010546
51MP0000778_abnormal_nervous_system1.34558536
52MP0002882_abnormal_neuron_morphology1.33591951
53MP0003879_abnormal_hair_cell1.30851555
54MP0004142_abnormal_muscle_tone1.30020367
55MP0008789_abnormal_olfactory_epithelium1.29478393
56MP0001905_abnormal_dopamine_level1.28054184
57MP0001502_abnormal_circadian_rhythm1.26555222
58MP0003890_abnormal_embryonic-extraembry1.24269286
59MP0004133_heterotaxia1.24108178
60MP0005248_abnormal_Harderian_gland1.23494378
61MP0002938_white_spotting1.22895999
62MP0008877_abnormal_DNA_methylation1.22002187
63MP0003123_paternal_imprinting1.19895183
64MP0001529_abnormal_vocalization1.18039815
65MP0004147_increased_porphyrin_level1.17471043
66MP0008058_abnormal_DNA_repair1.16565731
67MP0000013_abnormal_adipose_tissue1.13995440
68MP0003631_nervous_system_phenotype1.12412016
69MP0008961_abnormal_basal_metabolism1.12068919
70MP0004233_abnormal_muscle_weight1.11043638
71MP0003646_muscle_fatigue1.10434985
72MP0008995_early_reproductive_senescence1.10196562
73MP0005551_abnormal_eye_electrophysiolog1.07814728
74MP0002152_abnormal_brain_morphology1.05919005
75MP0004484_altered_response_of1.03693762
76MP0002229_neurodegeneration1.02907067
77MP0003121_genomic_imprinting0.99901356
78MP0003136_yellow_coat_color0.99822022
79MP0001485_abnormal_pinna_reflex0.95312327
80MP0002069_abnormal_eating/drinking_beha0.93507155
81MP0008872_abnormal_physiological_respon0.93398870
82MP0003698_abnormal_male_reproductive0.90708328
83MP0000569_abnormal_digit_pigmentation0.90420880
84MP0000747_muscle_weakness0.88980089
85MP0005084_abnormal_gallbladder_morpholo0.88860040
86MP0003690_abnormal_glial_cell0.87704957
87MP0004085_abnormal_heartbeat0.87561392
88MP0005623_abnormal_meninges_morphology0.87425033
89MP0000372_irregular_coat_pigmentation0.87216656
90MP0000427_abnormal_hair_cycle0.86414387
91MP0001929_abnormal_gametogenesis0.85894888
92MP0003283_abnormal_digestive_organ0.85486772
93MP0008874_decreased_physiological_sensi0.84463423
94MP0000566_synostosis0.83010366
95MP0003634_abnormal_glial_cell0.80460248
96MP0004215_abnormal_myocardial_fiber0.80362994
97MP0005171_absent_coat_pigmentation0.79725960
98MP0003632_abnormal_nervous_system0.78971040
99MP0002837_dystrophic_cardiac_calcinosis0.77331906
100MP0004043_abnormal_pH_regulation0.77038865
101MP0005195_abnormal_posterior_eye0.76126261
102MP0005394_taste/olfaction_phenotype0.76117931
103MP0005499_abnormal_olfactory_system0.76117931
104MP0005535_abnormal_body_temperature0.74442653
105MP0005187_abnormal_penis_morphology0.73189558
106MP0003172_abnormal_lysosome_physiology0.72808574
107MP0004036_abnormal_muscle_relaxation0.72775254
108MP0003861_abnormal_nervous_system0.72772827
109MP0001177_atelectasis0.70910361
110MP0002160_abnormal_reproductive_system0.70523968
111MP0000920_abnormal_myelination0.70471517
112MP0003943_abnormal_hepatobiliary_system0.70408030
113MP0001270_distended_abdomen0.70021990
114MP0003075_altered_response_to0.69384895
115MP0002638_abnormal_pupillary_reflex0.69324275
116MP0002752_abnormal_somatic_nervous0.68603627
117MP0000026_abnormal_inner_ear0.68273916
118MP0002210_abnormal_sex_determination0.68016655
119MP0003195_calcinosis0.67948757
120MP0000631_abnormal_neuroendocrine_gland0.67616209
121MP0004130_abnormal_muscle_cell0.65734979
122MP0001299_abnormal_eye_distance/0.64449229
123MP0006072_abnormal_retinal_apoptosis0.63669330
124MP0000604_amyloidosis0.63373834
125MP0002653_abnormal_ependyma_morphology0.62868746
126MP0003137_abnormal_impulse_conducting0.62769116
127MP0001963_abnormal_hearing_physiology0.62577868
128MP0001188_hyperpigmentation0.61943461
129MP0002090_abnormal_vision0.61804937
130MP0004742_abnormal_vestibular_system0.61687641
131MP0010386_abnormal_urinary_bladder0.59467404
132MP0005448_abnormal_energy_balance0.58477932

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.92548094
2Myokymia (HP:0002411)6.00574503
3Focal seizures (HP:0007359)5.31546394
4Visual hallucinations (HP:0002367)4.85138221
5Atonic seizures (HP:0010819)4.38666771
6Epileptic encephalopathy (HP:0200134)4.35415010
7Febrile seizures (HP:0002373)4.27979500
8Absence seizures (HP:0002121)4.17879067
9Progressive cerebellar ataxia (HP:0002073)4.04394355
10Action tremor (HP:0002345)3.74877866
11Dialeptic seizures (HP:0011146)3.71314130
12Tubulointerstitial nephritis (HP:0001970)3.67259292
13Generalized tonic-clonic seizures (HP:0002069)3.66785753
14Supranuclear gaze palsy (HP:0000605)3.54726181
15Truncal ataxia (HP:0002078)3.52632552
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.44299703
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.44299703
18Gait imbalance (HP:0002141)3.42202810
19Ankle clonus (HP:0011448)3.40278016
20Impaired vibration sensation in the lower limbs (HP:0002166)3.34690219
21Depression (HP:0000716)3.33254281
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.32956208
23Absent/shortened dynein arms (HP:0200106)3.32956208
24Medial flaring of the eyebrow (HP:0010747)3.22714923
25Type II lissencephaly (HP:0007260)3.20723803
26Congenital primary aphakia (HP:0007707)3.20677904
27Papilledema (HP:0001085)3.18843528
28Gaze-evoked nystagmus (HP:0000640)3.17358300
29Urinary bladder sphincter dysfunction (HP:0002839)3.16542628
30Postural instability (HP:0002172)3.14738894
31Pancreatic fibrosis (HP:0100732)3.14671104
32Dysdiadochokinesis (HP:0002075)3.12641017
33Abnormality of the lower motor neuron (HP:0002366)3.07242237
34Pancreatic cysts (HP:0001737)3.05824486
35Poor eye contact (HP:0000817)3.01387527
36Broad-based gait (HP:0002136)3.01154186
37Impaired smooth pursuit (HP:0007772)3.00545016
38Nephrogenic diabetes insipidus (HP:0009806)2.96493654
39Urinary urgency (HP:0000012)2.94011931
40Dysmetria (HP:0001310)2.89822402
41Anxiety (HP:0000739)2.88732731
42Nephronophthisis (HP:0000090)2.88297854
43Abnormal eating behavior (HP:0100738)2.86130528
44Pheochromocytoma (HP:0002666)2.85707323
45Chronic hepatic failure (HP:0100626)2.83617972
46Specific learning disability (HP:0001328)2.81980482
47Genital tract atresia (HP:0001827)2.80308806
48Impaired social interactions (HP:0000735)2.79644235
49Abnormal social behavior (HP:0012433)2.79644235
50Dyskinesia (HP:0100660)2.78322944
51Abnormality of the renal medulla (HP:0100957)2.77904809
52Dysmetric saccades (HP:0000641)2.75378100
53True hermaphroditism (HP:0010459)2.74192618
54Abnormality of ocular smooth pursuit (HP:0000617)2.72086937
55Mutism (HP:0002300)2.66554323
56Ventricular fibrillation (HP:0001663)2.66431136
57Retinal dysplasia (HP:0007973)2.66378339
58Progressive inability to walk (HP:0002505)2.66144196
59Vaginal atresia (HP:0000148)2.63741441
60Hemiparesis (HP:0001269)2.58649181
61Spastic gait (HP:0002064)2.57711240
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53123892
63Genetic anticipation (HP:0003743)2.48104348
64Molar tooth sign on MRI (HP:0002419)2.47541015
65Abnormality of midbrain morphology (HP:0002418)2.47541015
66Insomnia (HP:0100785)2.43944791
67Neuroendocrine neoplasm (HP:0100634)2.43690324
68Bradykinesia (HP:0002067)2.42880966
69Intention tremor (HP:0002080)2.41924875
70Hemiplegia (HP:0002301)2.41233356
71Exercise-induced myalgia (HP:0003738)2.36431237
72Amblyopia (HP:0000646)2.34951854
73Abnormal respiratory motile cilium physiology (HP:0012261)2.33778455
74Optic nerve hypoplasia (HP:0000609)2.32777578
75Poor coordination (HP:0002370)2.31531576
76Abnormal hair whorl (HP:0010721)2.29954567
77Scanning speech (HP:0002168)2.27734490
78Abnormality of the labia minora (HP:0012880)2.27657033
79Lissencephaly (HP:0001339)2.26502253
80Lower limb muscle weakness (HP:0007340)2.26398279
81Hyperventilation (HP:0002883)2.25130386
82Impaired vibratory sensation (HP:0002495)2.24795861
83Intestinal atresia (HP:0011100)2.23403817
84Abnormality of saccadic eye movements (HP:0000570)2.23371227
85Volvulus (HP:0002580)2.22269954
86Cystic liver disease (HP:0006706)2.22240099
87Fetal akinesia sequence (HP:0001989)2.21853765
88Morphological abnormality of the pyramidal tract (HP:0002062)2.19437667
89Torticollis (HP:0000473)2.18693252
90Insidious onset (HP:0003587)2.17592298
91Termporal pattern (HP:0011008)2.17592298
92Abnormal respiratory motile cilium morphology (HP:0005938)2.15725280
93Abnormal respiratory epithelium morphology (HP:0012253)2.15725280
94Agitation (HP:0000713)2.15071898
95Gonadotropin excess (HP:0000837)2.14333034
96Status epilepticus (HP:0002133)2.13684863
97Drooling (HP:0002307)2.09821207
98Excessive salivation (HP:0003781)2.09821207
99Abnormality of the corticospinal tract (HP:0002492)2.09382397
100Neurofibrillary tangles (HP:0002185)2.09323019
101Pointed chin (HP:0000307)2.08329956
102Abnormal ciliary motility (HP:0012262)2.07115587
103Amyotrophic lateral sclerosis (HP:0007354)2.06380068
104Hypsarrhythmia (HP:0002521)2.05174503
105Rimmed vacuoles (HP:0003805)2.03488921
106Polyphagia (HP:0002591)2.02945713
107Cerebral inclusion bodies (HP:0100314)2.02569369
108Diplopia (HP:0000651)2.02043614
109Abnormality of binocular vision (HP:0011514)2.02043614
110Bundle branch block (HP:0011710)2.00736387
111Neoplasm of the peripheral nervous system (HP:0100007)2.00313778
112Annular pancreas (HP:0001734)1.99683955
113Bony spicule pigmentary retinopathy (HP:0007737)1.99198615
114Failure to thrive in infancy (HP:0001531)1.99198279
115Stereotypic behavior (HP:0000733)1.99138806
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98485249
117Hypoplasia of the pons (HP:0012110)1.98405352
118Abnormal EKG (HP:0003115)1.97307876
119Clonus (HP:0002169)1.97157207
120Focal dystonia (HP:0004373)1.96728206
121Papillary thyroid carcinoma (HP:0002895)1.95970414
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.95945061
123Epileptiform EEG discharges (HP:0011182)1.93995752
124Gait ataxia (HP:0002066)1.93281606
125Cerebellar dysplasia (HP:0007033)1.93186627
126Central scotoma (HP:0000603)1.93172704
127Postaxial foot polydactyly (HP:0001830)1.93057229
128Hypoglycemic seizures (HP:0002173)1.92785678
129Postaxial hand polydactyly (HP:0001162)1.92371972
130Rhinitis (HP:0012384)1.92246405
131Megalencephaly (HP:0001355)1.91712990
132Resting tremor (HP:0002322)1.91547501
133EEG with generalized epileptiform discharges (HP:0011198)1.91281310
134Menstrual irregularities (HP:0000858)1.90757798
135Neuronal loss in central nervous system (HP:0002529)1.89890365
136Renal dysplasia (HP:0000110)1.89659984
137Congenital stationary night blindness (HP:0007642)1.88963238
138Curly hair (HP:0002212)1.88597870
139Abnormality of the pons (HP:0007361)1.88547295
140Absent eyebrow (HP:0002223)1.88033960
141Narrow forehead (HP:0000341)1.85948561
142Abnormal rod and cone electroretinograms (HP:0008323)1.85720973
143Spastic paraplegia (HP:0001258)1.85644339
144Limb dystonia (HP:0002451)1.85541730
145Absent speech (HP:0001344)1.85055529
146Neoplasm of the heart (HP:0100544)1.85004070
147Tubulointerstitial abnormality (HP:0001969)1.84908879
148Paraplegia (HP:0010550)1.82777940
149Inability to walk (HP:0002540)1.81242855
150Abnormality of the renal cortex (HP:0011035)1.80959659
151Hyperacusis (HP:0010780)1.80555665
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79711760
153Occipital encephalocele (HP:0002085)1.79518741
154Shoulder girdle muscle weakness (HP:0003547)1.76565984
155Sleep apnea (HP:0010535)1.75684724
156Pachygyria (HP:0001302)1.74684528
157Facial hemangioma (HP:0000329)1.74654710
158Broad foot (HP:0001769)1.73833328
159Oligodactyly (HP:0012165)1.71617291
160Poor suck (HP:0002033)1.71591233
161Thickened helices (HP:0000391)1.68509328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.70965594
2TSSK64.15460103
3MAP3K94.00813225
4TRIM283.57996484
5EPHA43.55473817
6MAP3K43.23089410
7MINK12.74878699
8PRKD32.69035933
9MARK12.57143433
10MAP2K72.52052653
11FRK2.50547072
12NTRK22.35515025
13PAK62.25080041
14EPHA32.21794395
15MAP2K42.14386313
16MAPK152.14221598
17DAPK22.09455844
18MAP3K122.00543273
19KSR21.96832473
20BCR1.87737453
21NTRK11.86645598
22CAMKK11.83983160
23PDK41.79320288
24PDK31.79320288
25STK381.77512378
26PNCK1.63364431
27TNIK1.53719651
28MAP4K21.52473314
29CDK51.49848143
30CDK191.48569252
31TIE11.45316583
32OBSCN1.43263161
33RIPK41.42912535
34ERBB31.39530752
35PHKG21.37130208
36PHKG11.37130208
37DAPK11.32380612
38SIK31.32019369
39STK38L1.31662903
40KSR11.30163942
41PINK11.20096828
42ARAF1.19982745
43PRKCG1.19193823
44UHMK11.17341341
45TAOK11.14331587
46FES1.13485973
47INSRR1.09597287
48GRK51.09483900
49PLK21.09414966
50TYRO31.08662462
51MAP3K131.04455137
52AKT31.01158091
53CAMKK20.98752818
54NEK10.98417952
55STK160.98183098
56BMPR1B0.96884733
57SIK20.96687669
58CDK30.95225760
59SGK4940.94842801
60SGK2230.94842801
61CAMK10.93739318
62MAPK130.93668497
63PRKCH0.93463387
64LATS20.93291307
65MAP3K20.92265690
66ALK0.92156645
67PRPF4B0.92066082
68PKN10.90134050
69PDK20.88829379
70FGFR20.88348673
71SGK20.87840452
72WNK10.87813533
73STK110.87453642
74CDK180.87386220
75MKNK20.87142135
76WNK30.86377482
77CDK150.86361391
78LMTK20.85828515
79CASK0.84753214
80SGK30.84492082
81CAMK2A0.84002318
82CDK140.83833178
83ADRBK20.83174723
84ERBB20.80992404
85RET0.80517794
86WEE10.79989807
87PDK10.79485609
88PTK2B0.79458452
89DYRK1B0.77553822
90DYRK30.77172482
91TNK20.76299033
92PAK30.74849651
93CDK11A0.73639931
94MARK30.69955025
95SGK10.68447806
96RAF10.68419759
97MAP3K10.68051775
98SCYL20.67457282
99RIPK10.67245944
100ICK0.65650963
101RPS6KB10.65282694
102RPS6KA40.64602916
103PRKCE0.64037842
104CAMK1G0.63620929
105PDPK10.62200423
106LATS10.61944705
107DYRK20.61739213
108PIK3CA0.59423312
109NUAK10.57757799
110GRK10.56454611
111RPS6KA30.56132542
112MARK20.55811341
113MAPK100.55021530
114CSNK1G10.53844370
115OXSR10.53091119
116CAMK2B0.52535313
117STK390.52184880
118RPS6KA50.51238210
119BRD40.48855175
120CDC42BPA0.48791671
121BRSK10.48100861
122MAP2K60.48063342
123CCNB10.46933047
124EIF2AK30.46228372
125MAP3K70.46147305
126PRKG10.45778699
127BRAF0.45324132
128DYRK1A0.44786653
129BCKDK0.44063778
130PRKCQ0.43132668
131PRKAA10.43113317
132CSNK1G30.42851850
133CAMK2G0.42387880
134PRKACA0.41611697
135NME10.40494003
136CSNK1A1L0.40158072
137VRK10.39391949
138CAMK2D0.37866785
139CSNK1G20.37417185
140PRKCZ0.37190462
141FYN0.35473423
142PRKCB0.35031372
143NEK60.35027529
144ACVR1B0.33438809
145CAMK40.33397738
146DMPK0.32318585
147RPS6KA20.28820893
148WNK40.28190951

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.93335376
2Synaptic vesicle cycle_Homo sapiens_hsa047213.31898687
3GABAergic synapse_Homo sapiens_hsa047272.93800447
4Olfactory transduction_Homo sapiens_hsa047402.71428657
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64710420
6Morphine addiction_Homo sapiens_hsa050322.61158002
7Circadian entrainment_Homo sapiens_hsa047132.60384887
8Long-term potentiation_Homo sapiens_hsa047202.54175564
9Glutamatergic synapse_Homo sapiens_hsa047242.40732084
10Amphetamine addiction_Homo sapiens_hsa050312.37230252
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35920025
12Dopaminergic synapse_Homo sapiens_hsa047282.08312012
13Salivary secretion_Homo sapiens_hsa049702.04888372
14Insulin secretion_Homo sapiens_hsa049112.04762973
15Protein export_Homo sapiens_hsa030601.92605214
16Gastric acid secretion_Homo sapiens_hsa049711.87568211
17Cholinergic synapse_Homo sapiens_hsa047251.79750473
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73434033
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73350068
20Taste transduction_Homo sapiens_hsa047421.73293992
21Renin secretion_Homo sapiens_hsa049241.72728719
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.72074215
23Steroid biosynthesis_Homo sapiens_hsa001001.71558613
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66615790
25Oxytocin signaling pathway_Homo sapiens_hsa049211.64699755
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61195752
27Cocaine addiction_Homo sapiens_hsa050301.60041147
28Calcium signaling pathway_Homo sapiens_hsa040201.57352203
29Long-term depression_Homo sapiens_hsa047301.56069797
30Serotonergic synapse_Homo sapiens_hsa047261.49469827
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48168318
32Butanoate metabolism_Homo sapiens_hsa006501.47155319
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46250308
34Regulation of autophagy_Homo sapiens_hsa041401.36894556
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33229576
36GnRH signaling pathway_Homo sapiens_hsa049121.32935917
37Type II diabetes mellitus_Homo sapiens_hsa049301.32157616
38Propanoate metabolism_Homo sapiens_hsa006401.31240883
39Basal transcription factors_Homo sapiens_hsa030221.29089847
40Collecting duct acid secretion_Homo sapiens_hsa049661.27476198
41Cardiac muscle contraction_Homo sapiens_hsa042601.27201393
42Gap junction_Homo sapiens_hsa045401.26646052
43cAMP signaling pathway_Homo sapiens_hsa040241.23261881
44Estrogen signaling pathway_Homo sapiens_hsa049151.22116508
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21388499
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21328899
47Dorso-ventral axis formation_Homo sapiens_hsa043201.11662446
48Oocyte meiosis_Homo sapiens_hsa041141.10348254
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07808681
50Melanogenesis_Homo sapiens_hsa049161.05967428
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05031535
52RNA degradation_Homo sapiens_hsa030181.02502488
53Glioma_Homo sapiens_hsa052140.99629737
54Nitrogen metabolism_Homo sapiens_hsa009100.97679674
55ErbB signaling pathway_Homo sapiens_hsa040120.97607321
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95170012
57Phototransduction_Homo sapiens_hsa047440.91153315
58Hedgehog signaling pathway_Homo sapiens_hsa043400.88664014
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.88294395
60Ether lipid metabolism_Homo sapiens_hsa005650.88258691
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88162486
62Glucagon signaling pathway_Homo sapiens_hsa049220.86127346
63Dilated cardiomyopathy_Homo sapiens_hsa054140.86003597
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84373177
65Vibrio cholerae infection_Homo sapiens_hsa051100.82090390
66Thyroid hormone synthesis_Homo sapiens_hsa049180.81471156
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.81181997
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81152858
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80656934
70Type I diabetes mellitus_Homo sapiens_hsa049400.77711133
71Axon guidance_Homo sapiens_hsa043600.77424068
72Pancreatic secretion_Homo sapiens_hsa049720.76841651
73MAPK signaling pathway_Homo sapiens_hsa040100.76298932
74beta-Alanine metabolism_Homo sapiens_hsa004100.75997103
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74555027
76Fanconi anemia pathway_Homo sapiens_hsa034600.74311105
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74298476
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72871290
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72246491
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65817793
81Choline metabolism in cancer_Homo sapiens_hsa052310.64180380
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.63817522
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63561016
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62221402
85Alcoholism_Homo sapiens_hsa050340.59992397
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59844960
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59532807
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59263197
89Huntingtons disease_Homo sapiens_hsa050160.58624487
90mTOR signaling pathway_Homo sapiens_hsa041500.57696456
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57071760
92Insulin signaling pathway_Homo sapiens_hsa049100.56623377
93mRNA surveillance pathway_Homo sapiens_hsa030150.56307128
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56256838
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55479895
96Inositol phosphate metabolism_Homo sapiens_hsa005620.55158542
97VEGF signaling pathway_Homo sapiens_hsa043700.54486877
98Endocytosis_Homo sapiens_hsa041440.52828140
99Circadian rhythm_Homo sapiens_hsa047100.52025539
100Oxidative phosphorylation_Homo sapiens_hsa001900.51930211
101Ras signaling pathway_Homo sapiens_hsa040140.51295243
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49074026
103FoxO signaling pathway_Homo sapiens_hsa040680.48970662
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48400624
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47614299
106Bile secretion_Homo sapiens_hsa049760.46567180
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44457385
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44404295
109AMPK signaling pathway_Homo sapiens_hsa041520.44194587
110Renal cell carcinoma_Homo sapiens_hsa052110.43817609
111Legionellosis_Homo sapiens_hsa051340.43549611
112Rap1 signaling pathway_Homo sapiens_hsa040150.43204010
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.41926123
114Parkinsons disease_Homo sapiens_hsa050120.40661464
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40588845
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.40381414
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.38842587
118African trypanosomiasis_Homo sapiens_hsa051430.38029811
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.37812857
120Non-small cell lung cancer_Homo sapiens_hsa052230.37308548
121Fatty acid biosynthesis_Homo sapiens_hsa000610.35968411
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.35891725
123Endometrial cancer_Homo sapiens_hsa052130.35474450
124Wnt signaling pathway_Homo sapiens_hsa043100.34380584
125Alzheimers disease_Homo sapiens_hsa050100.31964701
126Prion diseases_Homo sapiens_hsa050200.30808877
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29662687
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26291812
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25942386
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25082386
131Hippo signaling pathway_Homo sapiens_hsa043900.23887456

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