DNAJC28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.37221400
2lysine catabolic process (GO:0006554)5.37221400
3tricarboxylic acid cycle (GO:0006099)5.29287282
42-oxoglutarate metabolic process (GO:0006103)4.85452745
5aspartate family amino acid catabolic process (GO:0009068)4.76105463
6carnitine shuttle (GO:0006853)4.75558743
7fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72451926
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.70850128
9L-phenylalanine catabolic process (GO:0006559)4.70850128
10fatty acid transmembrane transport (GO:1902001)4.61316872
11alpha-linolenic acid metabolic process (GO:0036109)4.56131597
12fatty acid beta-oxidation (GO:0006635)4.54367377
13L-phenylalanine metabolic process (GO:0006558)4.49648867
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49648867
15glyoxylate metabolic process (GO:0046487)4.35971538
16cellular ketone body metabolic process (GO:0046950)4.32170123
17succinate metabolic process (GO:0006105)4.22972834
18fatty acid catabolic process (GO:0009062)4.17829991
19regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.14158441
20aromatic amino acid family catabolic process (GO:0009074)4.13776406
21fatty acid oxidation (GO:0019395)4.12417118
22short-chain fatty acid metabolic process (GO:0046459)4.06843212
23lipid oxidation (GO:0034440)4.06132250
24amino-acid betaine metabolic process (GO:0006577)4.02770315
25acetyl-CoA metabolic process (GO:0006084)4.01433176
26carnitine transmembrane transport (GO:1902603)3.99849172
27NADH metabolic process (GO:0006734)3.99177618
28regulation of sequestering of triglyceride (GO:0010889)3.97091180
29monocarboxylic acid catabolic process (GO:0072329)3.94017781
30kynurenine metabolic process (GO:0070189)3.94007928
31DNA deamination (GO:0045006)3.91564915
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.89087251
33carnitine transport (GO:0015879)3.87726019
34amino-acid betaine transport (GO:0015838)3.87726019
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.86824339
36bile acid biosynthetic process (GO:0006699)3.85511277
37behavioral response to nicotine (GO:0035095)3.81983661
38regulation of acyl-CoA biosynthetic process (GO:0050812)3.80412975
39branched-chain amino acid catabolic process (GO:0009083)3.80287438
40carnitine metabolic process (GO:0009437)3.74431507
41coenzyme catabolic process (GO:0009109)3.72569294
42oxaloacetate metabolic process (GO:0006107)3.70599419
43valine metabolic process (GO:0006573)3.69857079
44ketone body metabolic process (GO:1902224)3.69067710
45response to pheromone (GO:0019236)3.66932910
46sulfur amino acid catabolic process (GO:0000098)3.66174392
47indole-containing compound catabolic process (GO:0042436)3.64559950
48indolalkylamine catabolic process (GO:0046218)3.64559950
49tryptophan catabolic process (GO:0006569)3.64559950
50regulation of triglyceride catabolic process (GO:0010896)3.64487804
51tricarboxylic acid metabolic process (GO:0072350)3.63192974
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60308124
53branched-chain amino acid metabolic process (GO:0009081)3.52786537
54alpha-amino acid catabolic process (GO:1901606)3.50002547
55ethanol oxidation (GO:0006069)3.49843260
56protein K11-linked deubiquitination (GO:0035871)3.49046392
57C4-dicarboxylate transport (GO:0015740)3.48353886
58tryptophan metabolic process (GO:0006568)3.46599475
59cysteine metabolic process (GO:0006534)3.45060909
60water-soluble vitamin biosynthetic process (GO:0042364)3.44239897
61homocysteine metabolic process (GO:0050667)3.42895877
62DNA double-strand break processing (GO:0000729)3.40867477
63regulation of cofactor metabolic process (GO:0051193)3.40119812
64regulation of coenzyme metabolic process (GO:0051196)3.40119812
65sarcomere organization (GO:0045214)3.38472963
66platelet dense granule organization (GO:0060155)3.38191308
67carboxylic acid catabolic process (GO:0046395)3.38170898
68organic acid catabolic process (GO:0016054)3.38170898
69regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.37629412
70regulation of fatty acid oxidation (GO:0046320)3.35874585
71cellular amino acid catabolic process (GO:0009063)3.33609654
72dicarboxylic acid biosynthetic process (GO:0043650)3.32243083
73fucose catabolic process (GO:0019317)3.32097903
74L-fucose metabolic process (GO:0042354)3.32097903
75L-fucose catabolic process (GO:0042355)3.32097903
76regulation of glucokinase activity (GO:0033131)3.30311843
77regulation of hexokinase activity (GO:1903299)3.30311843
78serine family amino acid catabolic process (GO:0009071)3.27440504
79cardiac myofibril assembly (GO:0055003)3.27169386
80regulation of skeletal muscle contraction (GO:0014819)3.26497116
81bile acid metabolic process (GO:0008206)3.25087469
82presynaptic membrane assembly (GO:0097105)3.24696974
83quaternary ammonium group transport (GO:0015697)3.23709406
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21851225
85respiratory chain complex IV assembly (GO:0008535)3.21477480
86urea cycle (GO:0000050)3.19760511
87urea metabolic process (GO:0019627)3.19760511
88cardiac muscle contraction (GO:0060048)3.17892694
89glutamate metabolic process (GO:0006536)3.17464551
90positive regulation of fatty acid oxidation (GO:0046321)3.15069879
91biotin metabolic process (GO:0006768)3.14511348
92kidney morphogenesis (GO:0060993)3.12400498
93response to mercury ion (GO:0046689)3.11316158
94thioester metabolic process (GO:0035383)3.08498083
95acyl-CoA metabolic process (GO:0006637)3.08498083
96dicarboxylic acid catabolic process (GO:0043649)3.07405073
97regulation of relaxation of muscle (GO:1901077)3.07306940
98glycogen catabolic process (GO:0005980)3.07229495
99protein complex biogenesis (GO:0070271)3.06319216
100positive regulation of fatty acid beta-oxidation (GO:0032000)3.05978511
101myofibril assembly (GO:0030239)3.05178751
102negative regulation of lipase activity (GO:0060192)3.04671383
103negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.04380931
104mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04042986
105nonmotile primary cilium assembly (GO:0035058)3.03552517
106replication fork processing (GO:0031297)3.03487867
107complement activation, alternative pathway (GO:0006957)3.00186646
108fatty acid homeostasis (GO:0055089)2.98192854
109drug transmembrane transport (GO:0006855)2.96295503
110regulation of mesoderm development (GO:2000380)2.95873115
111protein polyglutamylation (GO:0018095)2.95599974
112indolalkylamine metabolic process (GO:0006586)2.94521318
113acylglycerol homeostasis (GO:0055090)2.94465649
114triglyceride homeostasis (GO:0070328)2.94465649
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93852328
116phospholipid homeostasis (GO:0055091)2.92181356
117cellular modified amino acid catabolic process (GO:0042219)2.92082945
118nitrogen cycle metabolic process (GO:0071941)2.91373734
119high-density lipoprotein particle remodeling (GO:0034375)2.91214998
120glucan catabolic process (GO:0009251)2.90574897
121regulation of cholesterol metabolic process (GO:0090181)2.90537850
122cellular glucuronidation (GO:0052695)2.89597621
123thioester biosynthetic process (GO:0035384)2.89158503
124axoneme assembly (GO:0035082)2.88192673
125mitochondrial respiratory chain complex assembly (GO:0033108)2.87728535
126regulation of action potential (GO:0098900)2.85023836
127preassembly of GPI anchor in ER membrane (GO:0016254)2.83789467
128cytochrome complex assembly (GO:0017004)2.82685941
129regulation of meiosis I (GO:0060631)2.82135931
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81624810
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.81624810
132regulation of translation, ncRNA-mediated (GO:0045974)2.81624810
133neuronal action potential (GO:0019228)2.78252271
134reflex (GO:0060004)2.77077537
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.76090874
136protein-cofactor linkage (GO:0018065)2.75131438
137mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74082007
138mitochondrial respiratory chain complex I assembly (GO:0032981)2.74082007
139NADH dehydrogenase complex assembly (GO:0010257)2.74082007
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73894289
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73894289
142presynaptic membrane organization (GO:0097090)2.73054595
143retinal cone cell development (GO:0046549)2.72984245
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.72963815
145gamma-aminobutyric acid transport (GO:0015812)2.72693751
146detection of light stimulus involved in sensory perception (GO:0050962)2.66909350
147detection of light stimulus involved in visual perception (GO:0050908)2.66909350
148piRNA metabolic process (GO:0034587)2.66838201
149G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65592812
150proline transport (GO:0015824)2.65074760
151recombinational repair (GO:0000725)2.65032912
152positive regulation of meiosis (GO:0045836)2.63836525
153double-strand break repair via homologous recombination (GO:0000724)2.62708052
154auditory receptor cell stereocilium organization (GO:0060088)2.58502056
155photoreceptor cell maintenance (GO:0045494)2.53164368
156startle response (GO:0001964)2.52286853
157keratinocyte development (GO:0003334)2.50571027
158protein neddylation (GO:0045116)2.50395857
159protein K6-linked ubiquitination (GO:0085020)2.50243241
160neural tube formation (GO:0001841)2.50046240
161neuron cell-cell adhesion (GO:0007158)2.48443287
162cilium organization (GO:0044782)2.48343961
163nephron tubule morphogenesis (GO:0072078)2.47780521
164nephron epithelium morphogenesis (GO:0072088)2.47780521
165anterograde synaptic vesicle transport (GO:0048490)2.47031143
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.46997944
167regulation of neurotransmitter uptake (GO:0051580)2.46997302
168adaptation of signaling pathway (GO:0023058)2.46808372
169postsynaptic membrane organization (GO:0001941)2.46717683
170inner ear receptor stereocilium organization (GO:0060122)2.46146593
171positive regulation of meiotic cell cycle (GO:0051446)2.45855939
172intraciliary transport (GO:0042073)2.45664889
173regulation of cilium movement (GO:0003352)2.44111134
174dopamine transport (GO:0015872)2.43137846
175protein localization to cilium (GO:0061512)2.42553011
176cilium assembly (GO:0042384)2.42458692
177transmission of nerve impulse (GO:0019226)2.42437501
178regulation of collateral sprouting (GO:0048670)2.42383020
179termination of RNA polymerase III transcription (GO:0006386)2.42297179
180transcription elongation from RNA polymerase III promoter (GO:0006385)2.42297179
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42222563
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41484349
183cornea development in camera-type eye (GO:0061303)2.40182382
184synapsis (GO:0007129)2.40111224
185spinal cord motor neuron differentiation (GO:0021522)2.38506455
186DNA demethylation (GO:0080111)2.38474196
187membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38358128
188nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.37935108
189establishment of protein localization to mitochondrial membrane (GO:0090151)2.36845657
190sulfation (GO:0051923)2.36451603
191glycosphingolipid biosynthetic process (GO:0006688)2.36284137
192cilium morphogenesis (GO:0060271)2.35689281

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.67152991
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70337480
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.34006660
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.63977769
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.31137337
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.70715479
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.70692454
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.13415539
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.89863513
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81641920
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.79141332
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77652380
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.71528400
14IGF1R_20145208_ChIP-Seq_DFB_Human2.60309894
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.25402082
16FUS_26573619_Chip-Seq_HEK293_Human2.21424167
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10274454
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07156461
19EWS_26573619_Chip-Seq_HEK293_Human2.06566827
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06285041
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04826481
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02084968
23GATA1_22025678_ChIP-Seq_K562_Human1.97868816
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.94327224
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83118319
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83044462
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.76431644
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.69274116
29EZH2_22144423_ChIP-Seq_EOC_Human1.64100949
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63400449
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60802877
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55501708
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55316505
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54724108
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54370486
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.53904364
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.53904364
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53536263
39MYC_18940864_ChIP-ChIP_HL60_Human1.52704609
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.50112541
41TP53_22573176_ChIP-Seq_HFKS_Human1.49195184
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.47975172
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.47424885
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46369543
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46255269
46STAT3_23295773_ChIP-Seq_U87_Human1.43278337
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42858468
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42416503
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41161858
50ZNF274_21170338_ChIP-Seq_K562_Hela1.41079541
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39658575
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35920869
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.33481781
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31430061
55NANOG_19829295_ChIP-Seq_ESCs_Human1.31218059
56SOX2_19829295_ChIP-Seq_ESCs_Human1.31218059
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.29720216
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.29516046
59TCF4_22108803_ChIP-Seq_LS180_Human1.29416423
60BCAT_22108803_ChIP-Seq_LS180_Human1.28899953
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28028285
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27670047
63TAF15_26573619_Chip-Seq_HEK293_Human1.27469114
64IRF1_19129219_ChIP-ChIP_H3396_Human1.25474158
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23636588
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23600177
67ELK1_19687146_ChIP-ChIP_HELA_Human1.23037470
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21924662
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.21924662
70GBX2_23144817_ChIP-Seq_PC3_Human1.21809722
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21671569
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21434108
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21434108
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.21194993
75* HTT_18923047_ChIP-ChIP_STHdh_Human1.20045941
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18787550
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17674430
78RNF2_27304074_Chip-Seq_NSC_Mouse1.17177061
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.17036741
80RUNX2_22187159_ChIP-Seq_PCA_Human1.16687323
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15265561
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14849040
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14488869
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13343878
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12385455
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.11425143
87P53_22387025_ChIP-Seq_ESCs_Mouse1.11041666
88CDX2_22108803_ChIP-Seq_LS180_Human1.08221518
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.06886978
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05354079
91DROSHA_22980978_ChIP-Seq_HELA_Human1.04617229
92AR_21572438_ChIP-Seq_LNCaP_Human1.03124178
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02349018
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02081613
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01369098
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00780567
97VDR_23849224_ChIP-Seq_CD4+_Human1.00742962
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00422664
99CBP_20019798_ChIP-Seq_JUKART_Human1.00422664
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00032630
101VDR_22108803_ChIP-Seq_LS180_Human0.99194142
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97825132
103HNF4A_19822575_ChIP-Seq_HepG2_Human0.97754561
104NCOR_22424771_ChIP-Seq_293T_Human0.97717238
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.97553678
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96599490
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96396063
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96327536
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92626612
110* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92392232
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89034408
112* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87391206
113CLOCK_20551151_ChIP-Seq_293T_Human0.87002340
114CBP_21632823_ChIP-Seq_H3396_Human0.86457562
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83861015
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.82634772
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81794340
118PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.80320607
119GATA1_19941826_ChIP-Seq_K562_Human0.77717456
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77511289
121GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76616569
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.74940583
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74739359
124SMAD4_21799915_ChIP-Seq_A2780_Human0.74378398
125* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72444833
126GATA2_19941826_ChIP-Seq_K562_Human0.72023485
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.71464261
128OCT4_20526341_ChIP-Seq_ESCs_Human0.68220793
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.66947641
130P53_21459846_ChIP-Seq_SAOS-2_Human0.66400161
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.66092816
132REST_21632747_ChIP-Seq_MESCs_Mouse0.65945124
133* AR_20517297_ChIP-Seq_VCAP_Human0.65402350
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65038245
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.64530247
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.64059077
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63942742
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.63744797
139STAT1_17558387_ChIP-Seq_HELA_Human0.63660082
140SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.62670391
141P300_19829295_ChIP-Seq_ESCs_Human0.62346278
142SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.62337892
143GATA3_26560356_Chip-Seq_TH1_Human0.62140883
144ZFP57_27257070_Chip-Seq_ESCs_Mouse0.61499324
145NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61327318
146NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61327318
147AR_25329375_ChIP-Seq_VCAP_Human0.61278177
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61229557
149ZNF263_19887448_ChIP-Seq_K562_Human0.61158693
150GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60593691
151* TCF4_23295773_ChIP-Seq_U87_Human0.60517646
152CTCF_27219007_Chip-Seq_Bcells_Human0.60350060
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60222433
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60026783
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.59950430
156MTF2_20144788_ChIP-Seq_MESCs_Mouse0.59263036
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59160586
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59139732
159ERG_20517297_ChIP-Seq_VCAP_Human0.58932432
160RARB_27405468_Chip-Seq_BRAIN_Mouse0.58864846
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.58835065
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.58793171
163REST_18959480_ChIP-ChIP_MESCs_Mouse0.58779457
164KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.58611782
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.58260272
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58195363
167ER_23166858_ChIP-Seq_MCF-7_Human0.57773734
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.57020416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.77172929
2MP0002837_dystrophic_cardiac_calcinosis4.59345182
3MP0003646_muscle_fatigue4.44794448
4MP0005360_urolithiasis4.23801151
5MP0005085_abnormal_gallbladder_physiolo4.13489366
6MP0005365_abnormal_bile_salt4.02422397
7MP0008875_abnormal_xenobiotic_pharmacok3.29304040
8MP0008877_abnormal_DNA_methylation3.11315102
9MP0004036_abnormal_muscle_relaxation3.00988374
10MP0004084_abnormal_cardiac_muscle2.91007275
11MP0002102_abnormal_ear_morphology2.89795358
12MP0004130_abnormal_muscle_cell2.75536371
13MP0000751_myopathy2.74247378
14MP0006072_abnormal_retinal_apoptosis2.59536581
15MP0000749_muscle_degeneration2.57531307
16MP0003787_abnormal_imprinting2.53290341
17MP0003806_abnormal_nucleotide_metabolis2.50972823
18MP0004215_abnormal_myocardial_fiber2.49553449
19MP0006292_abnormal_olfactory_placode2.40566780
20MP0010329_abnormal_lipoprotein_level2.36012763
21MP0000569_abnormal_digit_pigmentation2.34759770
22MP0003252_abnormal_bile_duct2.28770796
23MP0002736_abnormal_nociception_after2.28508506
24MP0006036_abnormal_mitochondrial_physio2.28314942
25MP0001968_abnormal_touch/_nociception2.22555285
26MP0003880_abnormal_central_pattern2.22350162
27MP0003890_abnormal_embryonic-extraembry2.18478135
28MP0005330_cardiomyopathy2.15918398
29MP0005332_abnormal_amino_acid2.11826500
30MP0005670_abnormal_white_adipose2.04199947
31MP0004885_abnormal_endolymph2.02672453
32MP0005253_abnormal_eye_physiology1.99026276
33MP0003195_calcinosis1.94033815
34MP0009046_muscle_twitch1.89570653
35MP0005083_abnormal_biliary_tract1.86138764
36MP0004145_abnormal_muscle_electrophysio1.80717462
37MP0009840_abnormal_foam_cell1.79518853
38MP0002269_muscular_atrophy1.79442997
39MP0001986_abnormal_taste_sensitivity1.78894279
40MP0009745_abnormal_behavioral_response1.77896379
41MP0001666_abnormal_nutrient_absorption1.77657984
42MP0002972_abnormal_cardiac_muscle1.75787225
43MP0004087_abnormal_muscle_fiber1.73971546
44MP0005620_abnormal_muscle_contractility1.72165055
45MP0002118_abnormal_lipid_homeostasis1.70675499
46MP0002272_abnormal_nervous_system1.66341547
47MP0003137_abnormal_impulse_conducting1.63465448
48MP0001764_abnormal_homeostasis1.63240026
49MP0002638_abnormal_pupillary_reflex1.63007746
50MP0004142_abnormal_muscle_tone1.60754562
51MP0005319_abnormal_enzyme/_coenzyme1.57704131
52MP0001529_abnormal_vocalization1.56906220
53MP0000427_abnormal_hair_cycle1.56131291
54MP0000631_abnormal_neuroendocrine_gland1.55825724
55MP0008775_abnormal_heart_ventricle1.55708437
56MP0005584_abnormal_enzyme/coenzyme_acti1.54299043
57MP0004043_abnormal_pH_regulation1.53245696
58MP0005174_abnormal_tail_pigmentation1.51663086
59MP0008872_abnormal_physiological_respon1.50376700
60MP0001486_abnormal_startle_reflex1.48904380
61MP0000372_irregular_coat_pigmentation1.48823845
62MP0003718_maternal_effect1.47144636
63MP0005385_cardiovascular_system_phenoty1.46191612
64MP0001544_abnormal_cardiovascular_syste1.46191612
65MP0004133_heterotaxia1.45758025
66MP0002106_abnormal_muscle_physiology1.44700478
67MP0003121_genomic_imprinting1.44489768
68MP0002971_abnormal_brown_adipose1.42811569
69MP0005666_abnormal_adipose_tissue1.42640837
70MP0004742_abnormal_vestibular_system1.42197984
71MP0008058_abnormal_DNA_repair1.42119026
72MP0006035_abnormal_mitochondrial_morpho1.41363329
73MP0005535_abnormal_body_temperature1.40873886
74MP0006138_congestive_heart_failure1.39893711
75MP0002938_white_spotting1.38556929
76MP0004484_altered_response_of1.37842108
77MP0003868_abnormal_feces_composition1.37345589
78MP0004085_abnormal_heartbeat1.36504169
79MP0000747_muscle_weakness1.35425131
80MP0002557_abnormal_social/conspecific_i1.34586244
81MP0001485_abnormal_pinna_reflex1.33974137
82MP0005389_reproductive_system_phenotype1.31230939
83MP0000609_abnormal_liver_physiology1.30955681
84MP0005084_abnormal_gallbladder_morpholo1.30931545
85MP0003656_abnormal_erythrocyte_physiolo1.29515788
86MP0003567_abnormal_fetal_cardiomyocyte1.29275936
87MP0002572_abnormal_emotion/affect_behav1.26309627
88MP0003136_yellow_coat_color1.26075920
89MP0010630_abnormal_cardiac_muscle1.23646362
90MP0001919_abnormal_reproductive_system1.23254491
91MP0002064_seizures1.23069460
92MP0005410_abnormal_fertilization1.21301316
93MP0002332_abnormal_exercise_endurance1.20255851
94MP0000383_abnormal_hair_follicle1.19165789
95MP0003635_abnormal_synaptic_transmissio1.18514372
96MP0003122_maternal_imprinting1.17664183
97MP0001293_anophthalmia1.16282687
98MP0005645_abnormal_hypothalamus_physiol1.15993553
99MP0005379_endocrine/exocrine_gland_phen1.15422367
100MP0002078_abnormal_glucose_homeostasis1.14766348
101MP0003221_abnormal_cardiomyocyte_apopto1.14691561
102MP0005266_abnormal_metabolism1.13962910
103MP0003950_abnormal_plasma_membrane1.13345593
104MP0005369_muscle_phenotype1.12640407
105MP0000759_abnormal_skeletal_muscle1.12462125
106MP0002067_abnormal_sensory_capabilities1.12263460
107MP0001501_abnormal_sleep_pattern1.12053304
108MP0003011_delayed_dark_adaptation1.11811122
109MP0002160_abnormal_reproductive_system1.11465276
110MP0004019_abnormal_vitamin_homeostasis1.11415491
111MP0005195_abnormal_posterior_eye1.10146307
112MP0005551_abnormal_eye_electrophysiolog1.09053025
113MP0002735_abnormal_chemical_nociception1.08740381
114MP0002734_abnormal_mechanical_nocicepti1.06591983
115MP0004147_increased_porphyrin_level1.06457270
116MP0003191_abnormal_cellular_cholesterol1.06020507
117MP0003283_abnormal_digestive_organ1.04683199
118MP0006276_abnormal_autonomic_nervous1.03539923
119MP0009697_abnormal_copulation1.03220912
120MP0004233_abnormal_muscle_weight1.02344010
121MP0002063_abnormal_learning/memory/cond1.01100932
122MP0005451_abnormal_body_composition1.00900930
123MP0002229_neurodegeneration1.00669436
124MP0002254_reproductive_system_inflammat0.99495442
125MP0002127_abnormal_cardiovascular_syste0.98969511
126MP0002138_abnormal_hepatobiliary_system0.98669407
127MP0001970_abnormal_pain_threshold0.98537170
128MP0003119_abnormal_digestive_system0.98534296
129MP0002752_abnormal_somatic_nervous0.97494054
130MP0001324_abnormal_eye_pigmentation0.96664456
131MP0001984_abnormal_olfaction0.96430584
132MP0002653_abnormal_ependyma_morphology0.96020777
133MP0002822_catalepsy0.95266230
134MP0000230_abnormal_systemic_arterial0.95081907
135MP0005334_abnormal_fat_pad0.94977724
136MP0009643_abnormal_urine_homeostasis0.94226075
137MP0000750_abnormal_muscle_regeneration0.93865091
138MP0002163_abnormal_gland_morphology0.93817233
139MP0000647_abnormal_sebaceous_gland0.93243741
140MP0005423_abnormal_somatic_nervous0.92842405
141MP0000015_abnormal_ear_pigmentation0.92427781
142MP0000026_abnormal_inner_ear0.91374924
143MP0002095_abnormal_skin_pigmentation0.90689378
144MP0002733_abnormal_thermal_nociception0.90195719
145MP0003937_abnormal_limbs/digits/tail_de0.89585145
146MP0000778_abnormal_nervous_system0.89457550
147MP0003186_abnormal_redox_activity0.89188465
148MP0001963_abnormal_hearing_physiology0.88252686
149MP0000013_abnormal_adipose_tissue0.87843490
150MP0005375_adipose_tissue_phenotype0.87565006
151MP0002909_abnormal_adrenal_gland0.85660743
152MP0002234_abnormal_pharynx_morphology0.85328355
153MP0010386_abnormal_urinary_bladder0.84439772
154MP0003690_abnormal_glial_cell0.84295521
155MP0003786_premature_aging0.81589418
156MP0005646_abnormal_pituitary_gland0.81519361
157MP0001905_abnormal_dopamine_level0.80958746
158MP0005391_vision/eye_phenotype0.80881688
159MP0002210_abnormal_sex_determination0.80744606
160MP0005376_homeostasis/metabolism_phenot0.79346024
161MP0003698_abnormal_male_reproductive0.79125922
162MP0001440_abnormal_grooming_behavior0.77639868
163MP0001929_abnormal_gametogenesis0.76677494
164MP0005636_abnormal_mineral_homeostasis0.72866924
165MP0005647_abnormal_sex_gland0.72557650
166MP0005165_increased_susceptibility_to0.71069085
167MP0002876_abnormal_thyroid_physiology0.69333555
168MP0009642_abnormal_blood_homeostasis0.67946463
169MP0005058_abnormal_lysosome_morphology0.64345103
170MP0004924_abnormal_behavior0.64071291
171MP0005386_behavior/neurological_phenoty0.64071291
172MP0008874_decreased_physiological_sensi0.62144929
173MP0004510_myositis0.61782272
174MP0009763_increased_sensitivity_to0.60941390
175MP0003953_abnormal_hormone_level0.60660594
176MP0003828_pulmonary_edema0.60585622
177MP0005448_abnormal_energy_balance0.59069364
178MP0005452_abnormal_adipose_tissue0.57714733
179MP0000598_abnormal_liver_morphology0.56133819
180MP0000604_amyloidosis0.55884347
181MP0000343_altered_response_to0.55876320

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.79419716
2Myoglobinuria (HP:0002913)4.57502335
3Ketosis (HP:0001946)4.34270730
4Hypoglycemic coma (HP:0001325)4.14747602
5Ketoacidosis (HP:0001993)4.07982200
6Exercise-induced muscle cramps (HP:0003710)4.06513779
7Abnormality of midbrain morphology (HP:0002418)3.95820371
8Molar tooth sign on MRI (HP:0002419)3.95820371
9Abnormality of fatty-acid metabolism (HP:0004359)3.88587802
10Calf muscle hypertrophy (HP:0008981)3.86701275
11Pancreatic cysts (HP:0001737)3.86644842
12Hyperammonemia (HP:0001987)3.84575154
13Congenital stationary night blindness (HP:0007642)3.74589626
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.72111283
15Muscle hypertrophy of the lower extremities (HP:0008968)3.71026425
16Cerebral edema (HP:0002181)3.70366255
17Sudden death (HP:0001699)3.68479305
18Pancreatic fibrosis (HP:0100732)3.65887497
19Intrahepatic cholestasis (HP:0001406)3.63093090
20True hermaphroditism (HP:0010459)3.57829898
21Ventricular tachycardia (HP:0004756)3.56285184
22Hyperglycinuria (HP:0003108)3.41337664
23Dicarboxylic aciduria (HP:0003215)3.40820798
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.40820798
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40643487
26Rhabdomyolysis (HP:0003201)3.36526821
27Nephronophthisis (HP:0000090)3.36137110
28Acute encephalopathy (HP:0006846)3.33299939
29Abnormal mitochondria in muscle tissue (HP:0008316)3.33158385
30Deep venous thrombosis (HP:0002625)3.26677238
31Abnormality of glycine metabolism (HP:0010895)3.25405262
32Abnormality of serine family amino acid metabolism (HP:0010894)3.25405262
33Xanthomatosis (HP:0000991)3.23837328
34Acute necrotizing encephalopathy (HP:0006965)3.17730056
35Hyperglycinemia (HP:0002154)3.17339949
36Hyperlipoproteinemia (HP:0010980)3.14054574
37Atrial fibrillation (HP:0005110)3.12823103
38Hepatic necrosis (HP:0002605)3.12708974
39Abnormality of the renal cortex (HP:0011035)3.04169523
40Hypoalphalipoproteinemia (HP:0003233)2.98553545
41Metabolic acidosis (HP:0001942)2.96288377
42Hyperventilation (HP:0002883)2.96284344
43Abnormality of the renal medulla (HP:0100957)2.93613120
44Prolonged partial thromboplastin time (HP:0003645)2.90118713
45Palpitations (HP:0001962)2.88920658
46Asymmetric septal hypertrophy (HP:0001670)2.86981550
47Increased muscle lipid content (HP:0009058)2.86961056
48Hypobetalipoproteinemia (HP:0003563)2.83126441
49Primary atrial arrhythmia (HP:0001692)2.81546658
50Lipoatrophy (HP:0100578)2.78257353
51Hypolipoproteinemia (HP:0010981)2.76886563
52Medial flaring of the eyebrow (HP:0010747)2.75973137
53Hyporeflexia of lower limbs (HP:0002600)2.74938717
54Proximal tubulopathy (HP:0000114)2.74779834
55Supraventricular tachycardia (HP:0004755)2.73343213
56Abnormality of the calf musculature (HP:0001430)2.73266599
57Pendular nystagmus (HP:0012043)2.70576098
58Intestinal atresia (HP:0011100)2.67750457
59Lethargy (HP:0001254)2.67160573
60Hyperinsulinemic hypoglycemia (HP:0000825)2.64008519
61Lactic acidosis (HP:0003128)2.63326196
62Supraventricular arrhythmia (HP:0005115)2.63030895
63Progressive macrocephaly (HP:0004481)2.62366973
64Syncope (HP:0001279)2.61764248
65Type II lissencephaly (HP:0007260)2.55609765
66Dilated cardiomyopathy (HP:0001644)2.54990451
67Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54246721
68Abolished electroretinogram (ERG) (HP:0000550)2.54145796
69Mitochondrial inheritance (HP:0001427)2.54056374
70Chronic hepatic failure (HP:0100626)2.52652884
71Abnormality of the intrinsic pathway (HP:0010989)2.52383052
72Gout (HP:0001997)2.52328871
73Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52317055
74Bundle branch block (HP:0011710)2.51854508
75Abnormality of the labia minora (HP:0012880)2.51736538
76Generalized aminoaciduria (HP:0002909)2.50027171
77Increased CSF lactate (HP:0002490)2.49764396
78Hepatocellular necrosis (HP:0001404)2.49451307
79Complement deficiency (HP:0004431)2.49339963
80Cholelithiasis (HP:0001081)2.48425919
81Abnormality of serum amino acid levels (HP:0003112)2.46062843
82Muscle fiber splitting (HP:0003555)2.43896758
83Vomiting (HP:0002013)2.40832718
84Increased intramyocellular lipid droplets (HP:0012240)2.39280041
85Abnormal gallbladder morphology (HP:0012437)2.36508218
86Decreased circulating renin level (HP:0003351)2.36231817
87Gaze-evoked nystagmus (HP:0000640)2.36087632
88Ragged-red muscle fibers (HP:0003200)2.34519955
89Progressive cerebellar ataxia (HP:0002073)2.32868004
90Hypothermia (HP:0002045)2.30601019
91Abnormality of purine metabolism (HP:0004352)2.30298969
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28889478
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28668613
94Abnormality of alanine metabolism (HP:0010916)2.28668613
95Hyperalaninemia (HP:0003348)2.28668613
96Progressive inability to walk (HP:0002505)2.28258325
97Subaortic stenosis (HP:0001682)2.28110101
98Abnormality of the left ventricular outflow tract (HP:0011103)2.28110101
99Right ventricular cardiomyopathy (HP:0011663)2.27671413
100Central scotoma (HP:0000603)2.27639569
101Cystic liver disease (HP:0006706)2.26636230
102Hypercholesterolemia (HP:0003124)2.26270823
103Oligomenorrhea (HP:0000876)2.26206036
104Methylmalonic acidemia (HP:0002912)2.24880932
105Furrowed tongue (HP:0000221)2.24770342
106Abnormal biliary tract physiology (HP:0012439)2.24456301
107Bile duct proliferation (HP:0001408)2.24456301
108Sclerocornea (HP:0000647)2.24365367
109Renal cortical cysts (HP:0000803)2.22069584
110Stomach cancer (HP:0012126)2.19410838
111Epidermoid cyst (HP:0200040)2.19132624
112Heart block (HP:0012722)2.18400973
113Large for gestational age (HP:0001520)2.16339600
114Abnormality of methionine metabolism (HP:0010901)2.16311536
115Polydipsia (HP:0001959)2.15151624
116Abnormal drinking behavior (HP:0030082)2.15151624
117Abnormality of macular pigmentation (HP:0008002)2.14466502
118Inability to walk (HP:0002540)2.13755208
119Aplasia/Hypoplasia of the tongue (HP:0010295)2.12937656
120Lipid accumulation in hepatocytes (HP:0006561)2.12837816
121Hyperbilirubinemia (HP:0002904)2.12104564
122Hyperuricemia (HP:0002149)2.12097028
123Increased purine levels (HP:0004368)2.12097028
124Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11319741
125Muscle stiffness (HP:0003552)2.11202213
126Difficulty running (HP:0009046)2.10976534
127EMG: myopathic abnormalities (HP:0003458)2.10563730
128Abnormal rod and cone electroretinograms (HP:0008323)2.09606896
129Atrioventricular block (HP:0001678)2.09030919
130Abnormality of sulfur amino acid metabolism (HP:0004339)2.08891275
131Delayed CNS myelination (HP:0002188)2.07882783
132Oligodactyly (hands) (HP:0001180)2.07519644
133Aplasia/Hypoplasia of the uvula (HP:0010293)2.07419459
134Methylmalonic aciduria (HP:0012120)2.05775247
135Abnormality of glycolysis (HP:0004366)2.03836128
136Increased serum pyruvate (HP:0003542)2.03836128
137Gait imbalance (HP:0002141)2.02752883
138Neuroendocrine neoplasm (HP:0100634)2.02293330
139Hyperglycemia (HP:0003074)2.02007056
140Joint hemorrhage (HP:0005261)2.01971615
141Attenuation of retinal blood vessels (HP:0007843)2.01606610
142Lissencephaly (HP:0001339)2.00819093
143Anencephaly (HP:0002323)2.00076141
144Broad-based gait (HP:0002136)2.00041508
145Nephrogenic diabetes insipidus (HP:0009806)1.99929023
146Aplasia/hypoplasia of the uterus (HP:0008684)1.98854300
147Genetic anticipation (HP:0003743)1.98460522
148Tubular atrophy (HP:0000092)1.97658776
149Male pseudohermaphroditism (HP:0000037)1.97477778
150Drooling (HP:0002307)1.97115153
151Polyuria (HP:0000103)1.95998098
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.95422078
153Hypoplasia of the fovea (HP:0007750)1.95422078
154Hypoplasia of the uterus (HP:0000013)1.95377527
155Congenital sensorineural hearing impairment (HP:0008527)1.94050472
156Genital tract atresia (HP:0001827)1.93366422
157Congenital hepatic fibrosis (HP:0002612)1.92795311
158Congenital primary aphakia (HP:0007707)1.92234590
159Colon cancer (HP:0003003)1.92025871
160Absent speech (HP:0001344)1.91360619
161Hemiparesis (HP:0001269)1.89053828
1623-Methylglutaconic aciduria (HP:0003535)1.88040110
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.84587455
164Dialeptic seizures (HP:0011146)1.83619815
165Anophthalmia (HP:0000528)1.83283095
166Vaginal atresia (HP:0000148)1.82316853
167Optic disc pallor (HP:0000543)1.81935609
168Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76986507
169Focal motor seizures (HP:0011153)1.75264594
170Volvulus (HP:0002580)1.74519765
171Dynein arm defect of respiratory motile cilia (HP:0012255)1.74281102
172Absent/shortened dynein arms (HP:0200106)1.74281102
173Increased corneal curvature (HP:0100692)1.74224401
174Keratoconus (HP:0000563)1.74224401
175Optic nerve hypoplasia (HP:0000609)1.73659497
176Hypomagnesemia (HP:0002917)1.73445445
177Congenital malformation of the right heart (HP:0011723)1.72871512
178Double outlet right ventricle (HP:0001719)1.72871512
179Abnormality of the fovea (HP:0000493)1.72710806
180Gastrointestinal atresia (HP:0002589)1.71392739
181Excessive salivation (HP:0003781)1.71228110
182Chorioretinal atrophy (HP:0000533)1.70675192
183Postaxial hand polydactyly (HP:0001162)1.68883008

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.07158996
2PDK35.02941874
3PDK45.02941874
4TNIK3.43948837
5TTN3.17591884
6BMPR1B3.10230655
7OBSCN3.03731212
8PHKG22.97999516
9PHKG12.97999516
10PINK12.95882279
11PDK22.89814916
12MAP4K22.54716805
13ADRBK22.50445169
14NUAK12.48104352
15ACVR1B2.44643055
16ZAK2.37420478
17LMTK22.29195580
18MYLK2.22542522
19INSRR1.98059856
20TRIM281.89754891
21PKN21.70619683
22NEK11.69880110
23MAP3K71.68594974
24MAP2K31.66029001
25RIPK11.62432188
26MAPK131.58762056
27GRK71.58366113
28MAP2K41.56462609
29PIK3CA1.49492468
30WNK41.48811247
31MAPK151.48560955
32PLK21.46760056
33MUSK1.43328528
34MST41.43259221
35TRIB31.40781529
36FGFR41.35991540
37TXK1.35563807
38ERN11.35170683
39BCR1.28018146
40MARK11.26456238
41CSNK1G11.25517337
42PIK3CG1.21866716
43PRKAA21.20707088
44PNCK1.19807671
45MKNK21.19694559
46CSNK1G21.18281178
47PBK1.17566464
48PRKAA11.14771921
49MAPK121.14073869
50SIK11.12973279
51TIE11.11038582
52MAP2K61.06287304
53STK161.06246499
54STK241.05031998
55PLK31.01867678
56CSNK1G31.01632451
57TLK10.99917954
58ICK0.98319332
59FLT30.95741766
60DYRK20.94135290
61PRKD30.93260668
62CAMK10.92214084
63DAPK20.91983106
64PRKCG0.90278767
65CSNK1A1L0.89769117
66FGFR20.88342535
67CAMK40.87975363
68ERBB30.85523990
69PAK30.85480054
70EPHA40.84295066
71ADRBK10.82870109
72CAMK2D0.81606991
73EIF2AK30.81486888
74MAP3K40.81126029
75TGFBR10.81074836
76WEE10.79409756
77CAMK1D0.78814861
78NEK90.77261408
79MAP3K50.77025846
80WNK30.76866163
81STK30.76118593
82PDK10.75819325
83STK390.75438961
84PDPK10.75186686
85PLK40.74898254
86MAPK110.72612182
87CAMK1G0.72170862
88DMPK0.72053625
89SGK20.68809210
90MAP3K30.67075843
91PRKD10.65563508
92OXSR10.64667840
93NLK0.63403983
94PLK10.60714096
95SGK30.60279570
96BRSK20.60084617
97STK38L0.59666263
98PRKACG0.58405547
99SGK4940.58123014
100SGK2230.58123014
101VRK10.56778394
102NME10.56427332
103CAMK2G0.56246119
104PTK2B0.56136517
105TAF10.55747404
106MKNK10.54974348
107MAPKAPK30.53928949
108TAOK20.52726168
109NTRK30.52715002
110LATS10.52532301
111EIF2AK10.52138157
112CAMK2A0.52069862
113PRKCE0.51332472
114TEC0.48122186
115CDK30.47865289
116PRKACB0.46073651
117GRK10.45984506
118STK380.45498223
119GRK50.44611153
120MAPK40.43881426
121EIF2AK20.43737131
122PRKCI0.43049451
123CSNK1A10.42718935
124CASK0.42320278
125SIK30.41857185
126PRKACA0.41383332
127AKT30.41109053
128PRKCH0.40929671
129FER0.39660569
130MAP2K10.39552367
131PKN10.38737889
132TAOK30.37894193
133JAK20.37385607
134CSNK1D0.36989933
135CDC70.36488452
136PRKG10.35530023
137CDK190.35492740
138CHEK20.34914662
139MAPK70.34730853
140ATM0.34637432
141TTK0.33899297
142MARK30.33856513
143ATR0.32499864
144STK110.31824473
145DYRK1A0.31268962
146MAP3K110.30836800
147FRK0.30219861
148PRKCQ0.29708757
149RPS6KA30.28997066
150PTK60.28950810
151TGFBR20.28644185
152TAOK10.28276220
153MAP2K70.26936310
154SGK10.26343667
155WNK10.26113784
156PRKCZ0.25431035
157AKT20.22960206
158PDGFRA0.22370563
159RET0.21965381
160JAK10.20293000
161NTRK20.19143490
162PRKCA0.18662035

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.62011553
2Propanoate metabolism_Homo sapiens_hsa006403.58772773
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41004206
4Fatty acid degradation_Homo sapiens_hsa000713.22550095
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.97033885
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87489754
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.87135616
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71408586
9Protein export_Homo sapiens_hsa030602.60077739
10Fatty acid metabolism_Homo sapiens_hsa012122.56580988
11Butanoate metabolism_Homo sapiens_hsa006502.53644286
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38401232
13Pyruvate metabolism_Homo sapiens_hsa006202.32964283
14Nitrogen metabolism_Homo sapiens_hsa009102.29281770
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.26752589
16Arginine biosynthesis_Homo sapiens_hsa002202.18241361
17RNA polymerase_Homo sapiens_hsa030202.17008544
18Carbon metabolism_Homo sapiens_hsa012002.08166797
19Tryptophan metabolism_Homo sapiens_hsa003802.06605079
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01841699
21Peroxisome_Homo sapiens_hsa041461.97153273
22PPAR signaling pathway_Homo sapiens_hsa033201.94553838
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90978757
24Linoleic acid metabolism_Homo sapiens_hsa005911.88317121
25Nicotine addiction_Homo sapiens_hsa050331.88075217
26Homologous recombination_Homo sapiens_hsa034401.88059729
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80634391
28Basal transcription factors_Homo sapiens_hsa030221.79124639
29Fanconi anemia pathway_Homo sapiens_hsa034601.74987524
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71785607
31Fatty acid elongation_Homo sapiens_hsa000621.69809919
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67396266
33Sulfur metabolism_Homo sapiens_hsa009201.64584904
34Proteasome_Homo sapiens_hsa030501.63100461
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61738837
36Ether lipid metabolism_Homo sapiens_hsa005651.56968110
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54763514
38beta-Alanine metabolism_Homo sapiens_hsa004101.53119598
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52367497
40Starch and sucrose metabolism_Homo sapiens_hsa005001.48924780
41Cardiac muscle contraction_Homo sapiens_hsa042601.42472512
42Oxidative phosphorylation_Homo sapiens_hsa001901.41947498
43Biosynthesis of amino acids_Homo sapiens_hsa012301.40033332
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39414088
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38276585
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34036302
47Parkinsons disease_Homo sapiens_hsa050121.32700556
48Complement and coagulation cascades_Homo sapiens_hsa046101.31757013
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27582323
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26775659
51Olfactory transduction_Homo sapiens_hsa047401.24768663
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.24238045
53RNA degradation_Homo sapiens_hsa030181.23430892
54Steroid biosynthesis_Homo sapiens_hsa001001.22100549
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17428765
56Selenocompound metabolism_Homo sapiens_hsa004501.15306726
57Morphine addiction_Homo sapiens_hsa050321.13245820
58Collecting duct acid secretion_Homo sapiens_hsa049661.12636666
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11584767
60Chemical carcinogenesis_Homo sapiens_hsa052041.10403854
61Phenylalanine metabolism_Homo sapiens_hsa003601.08369399
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05789521
63Bile secretion_Homo sapiens_hsa049761.03241391
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02597958
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98889898
66Alzheimers disease_Homo sapiens_hsa050100.98363766
67ABC transporters_Homo sapiens_hsa020100.97924762
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97731941
69Caffeine metabolism_Homo sapiens_hsa002320.97420673
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.95742884
71Taste transduction_Homo sapiens_hsa047420.94858070
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94408136
73Fatty acid biosynthesis_Homo sapiens_hsa000610.94073481
74Retinol metabolism_Homo sapiens_hsa008300.91080538
75Glycerolipid metabolism_Homo sapiens_hsa005610.90499463
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89862351
77Glucagon signaling pathway_Homo sapiens_hsa049220.85743148
78Tyrosine metabolism_Homo sapiens_hsa003500.85453527
79Serotonergic synapse_Homo sapiens_hsa047260.83369858
80Fat digestion and absorption_Homo sapiens_hsa049750.82632408
81Lysine degradation_Homo sapiens_hsa003100.82566112
82Purine metabolism_Homo sapiens_hsa002300.81712344
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81533991
84One carbon pool by folate_Homo sapiens_hsa006700.81051665
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.79430886
86Fructose and mannose metabolism_Homo sapiens_hsa000510.78461895
87Histidine metabolism_Homo sapiens_hsa003400.77631091
88Huntingtons disease_Homo sapiens_hsa050160.77550817
89Arginine and proline metabolism_Homo sapiens_hsa003300.76242601
90Circadian entrainment_Homo sapiens_hsa047130.76177052
91Glutamatergic synapse_Homo sapiens_hsa047240.75217242
92Pyrimidine metabolism_Homo sapiens_hsa002400.75182412
93Dilated cardiomyopathy_Homo sapiens_hsa054140.74998015
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69900963
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69044080
96Non-homologous end-joining_Homo sapiens_hsa034500.68421631
97Staphylococcus aureus infection_Homo sapiens_hsa051500.66380488
98Insulin resistance_Homo sapiens_hsa049310.64861663
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64543173
100Galactose metabolism_Homo sapiens_hsa000520.64248946
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.63017635
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.61327603
103Ovarian steroidogenesis_Homo sapiens_hsa049130.60178374
104Arachidonic acid metabolism_Homo sapiens_hsa005900.58314394
105Sulfur relay system_Homo sapiens_hsa041220.58027689
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57118376
107Folate biosynthesis_Homo sapiens_hsa007900.56700861
108Mineral absorption_Homo sapiens_hsa049780.56331143
109Metabolic pathways_Homo sapiens_hsa011000.55540172
110Pentose phosphate pathway_Homo sapiens_hsa000300.55515670
111Phototransduction_Homo sapiens_hsa047440.54449664
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54042234
113Dopaminergic synapse_Homo sapiens_hsa047280.52120558
114Dorso-ventral axis formation_Homo sapiens_hsa043200.45637693
115RNA transport_Homo sapiens_hsa030130.44071870
116Vitamin B6 metabolism_Homo sapiens_hsa007500.42559575
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42374863
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42095945
119AMPK signaling pathway_Homo sapiens_hsa041520.41974527
120Nucleotide excision repair_Homo sapiens_hsa034200.38842371
121Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38599663
122Mismatch repair_Homo sapiens_hsa034300.38389423
123Salivary secretion_Homo sapiens_hsa049700.38236100
124Insulin signaling pathway_Homo sapiens_hsa049100.37398134
125Basal cell carcinoma_Homo sapiens_hsa052170.36853788
126Hedgehog signaling pathway_Homo sapiens_hsa043400.33656230
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28456432
128Glutathione metabolism_Homo sapiens_hsa004800.27412712
129Calcium signaling pathway_Homo sapiens_hsa040200.26625992
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25553122
131Insulin secretion_Homo sapiens_hsa049110.23705495
132Vitamin digestion and absorption_Homo sapiens_hsa049770.21571152
133Circadian rhythm_Homo sapiens_hsa047100.21021542
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.19194015
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17505513
136Type II diabetes mellitus_Homo sapiens_hsa049300.16908221
137Renin secretion_Homo sapiens_hsa049240.14466919
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.14332319
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12645084
140GABAergic synapse_Homo sapiens_hsa047270.12472896
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10833214
142Regulation of autophagy_Homo sapiens_hsa041400.10000347
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08645503
144Glycosaminoglycan degradation_Homo sapiens_hsa005310.08299196
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06834620
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06667068

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