DNAJC30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.21736536
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.36771714
3respiratory electron transport chain (GO:0022904)6.20477625
4ATP synthesis coupled proton transport (GO:0015986)6.13793056
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.13793056
6electron transport chain (GO:0022900)6.03361898
7chaperone-mediated protein transport (GO:0072321)5.30184676
8protein complex biogenesis (GO:0070271)4.99959185
9regulation of oxidative phosphorylation (GO:0002082)4.66949387
10mitochondrial respiratory chain complex assembly (GO:0033108)4.62090548
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60569314
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.60569314
13NADH dehydrogenase complex assembly (GO:0010257)4.60569314
14respiratory chain complex IV assembly (GO:0008535)4.19794527
15ubiquinone biosynthetic process (GO:0006744)4.17044746
16quinone biosynthetic process (GO:1901663)4.17044746
17galactose catabolic process (GO:0019388)4.14657193
18dopamine transport (GO:0015872)3.98405575
19regulation of mitochondrial translation (GO:0070129)3.95503143
20proteasome assembly (GO:0043248)3.92564838
21ubiquinone metabolic process (GO:0006743)3.83775633
22cytochrome complex assembly (GO:0017004)3.81260371
23hydrogen ion transmembrane transport (GO:1902600)3.74432375
24galactose metabolic process (GO:0006012)3.73681772
25ATP biosynthetic process (GO:0006754)3.71396325
26regulation of cellular respiration (GO:0043457)3.71087665
27iron-sulfur cluster assembly (GO:0016226)3.65707285
28metallo-sulfur cluster assembly (GO:0031163)3.65707285
29inner mitochondrial membrane organization (GO:0007007)3.61763887
30purine nucleoside triphosphate biosynthetic process (GO:0009145)3.57961803
31purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.56963263
32oxidative phosphorylation (GO:0006119)3.49929864
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.49498826
34DNA deamination (GO:0045006)3.46302554
35protein targeting to mitochondrion (GO:0006626)3.42985836
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41993729
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41993729
38protein-cofactor linkage (GO:0018065)3.41392738
39NADH metabolic process (GO:0006734)3.39669253
40proton transport (GO:0015992)3.37300217
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.37213880
42L-phenylalanine metabolic process (GO:0006558)3.37213880
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36644467
44L-phenylalanine catabolic process (GO:0006559)3.36644467
45hydrogen transport (GO:0006818)3.31448438
46cullin deneddylation (GO:0010388)3.24397024
47aerobic respiration (GO:0009060)3.24222510
48succinate metabolic process (GO:0006105)3.23471044
49establishment of protein localization to mitochondrion (GO:0072655)3.21729244
50aldehyde catabolic process (GO:0046185)3.21046678
51ketone body metabolic process (GO:1902224)3.18284012
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.16433845
53ATP hydrolysis coupled proton transport (GO:0015991)3.16433845
54protein deneddylation (GO:0000338)3.13207715
55tricarboxylic acid cycle (GO:0006099)3.13201804
56protein neddylation (GO:0045116)3.10565400
57mannosylation (GO:0097502)3.09214582
58GTP biosynthetic process (GO:0006183)3.06447546
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05929591
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.04631688
61quinone metabolic process (GO:1901661)3.04407496
62norepinephrine metabolic process (GO:0042415)3.03582452
63peroxisome fission (GO:0016559)2.99790141
64C-terminal protein lipidation (GO:0006501)2.99107198
65protein localization to mitochondrion (GO:0070585)2.98998435
66negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95250148
67GDP-mannose metabolic process (GO:0019673)2.94962238
68mitochondrion morphogenesis (GO:0070584)2.94303188
69guanosine-containing compound biosynthetic process (GO:1901070)2.92401871
70L-methionine salvage (GO:0071267)2.91133534
71L-methionine biosynthetic process (GO:0071265)2.91133534
72amino acid salvage (GO:0043102)2.91133534
73mitochondrial transport (GO:0006839)2.90785563
74preassembly of GPI anchor in ER membrane (GO:0016254)2.89274238
75base-excision repair, AP site formation (GO:0006285)2.86498964
76virion assembly (GO:0019068)2.85974129
77pseudouridine synthesis (GO:0001522)2.85468210
78pattern specification involved in kidney development (GO:0061004)2.85336777
79phosphate ion transmembrane transport (GO:0035435)2.85000618
80pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82245856
81signal peptide processing (GO:0006465)2.76994003
82ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.76776176
83branched-chain amino acid catabolic process (GO:0009083)2.76775979
84cellular ketone body metabolic process (GO:0046950)2.75957909
85synaptic vesicle exocytosis (GO:0016079)2.74733941
86positive regulation of TOR signaling (GO:0032008)2.74387180
87C-terminal protein amino acid modification (GO:0018410)2.73696324
88nucleoside triphosphate biosynthetic process (GO:0009142)2.72536121
89anterograde synaptic vesicle transport (GO:0048490)2.68389349
90intracellular protein transmembrane import (GO:0044743)2.68097374
91regulation of cellular amino acid metabolic process (GO:0006521)2.67703104
92protein maturation by protein folding (GO:0022417)2.67637185
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.67483289
94vocalization behavior (GO:0071625)2.64690516
95oxaloacetate metabolic process (GO:0006107)2.64472046
96tRNA processing (GO:0008033)2.63697790
97phosphate ion transport (GO:0006817)2.63469318
98ribosomal small subunit biogenesis (GO:0042274)2.63020236
99aromatic amino acid family catabolic process (GO:0009074)2.62995709
100regulation of dopamine metabolic process (GO:0042053)2.62127652
101regulation of catecholamine metabolic process (GO:0042069)2.62127652
102regulation of acyl-CoA biosynthetic process (GO:0050812)2.59680249
103protein insertion into membrane (GO:0051205)2.58953515
104positive regulation of mitochondrial fission (GO:0090141)2.58339985
105rRNA modification (GO:0000154)2.57808145
106catecholamine transport (GO:0051937)2.57062793
107transferrin transport (GO:0033572)2.55475815
108rRNA methylation (GO:0031167)2.55287950
109regulation of cofactor metabolic process (GO:0051193)2.55074214
110regulation of coenzyme metabolic process (GO:0051196)2.55074214
111protein polyglutamylation (GO:0018095)2.52961792
112neuron cell-cell adhesion (GO:0007158)2.52197689
113generation of precursor metabolites and energy (GO:0006091)2.52173305
114transcription from RNA polymerase I promoter (GO:0006360)2.49147628
115tRNA modification (GO:0006400)2.49029078
116behavioral response to nicotine (GO:0035095)2.48929653
117neuronal action potential propagation (GO:0019227)2.48586581
118RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.48131297
119deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.46756034
120purine nucleoside monophosphate biosynthetic process (GO:0009127)2.46196992
121purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.46196992
122neurotransmitter biosynthetic process (GO:0042136)2.44506999
123termination of RNA polymerase III transcription (GO:0006386)2.41752906
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.41752906
125positive regulation of triglyceride biosynthetic process (GO:0010867)2.41557275
126cellular respiration (GO:0045333)2.40410763
127purine nucleoside biosynthetic process (GO:0042451)2.38498477
128purine ribonucleoside biosynthetic process (GO:0046129)2.38498477
129nitric oxide biosynthetic process (GO:0006809)2.38099121
130ncRNA 3-end processing (GO:0043628)2.38045527
131DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.36695649
132polyketide metabolic process (GO:0030638)2.36533577
133doxorubicin metabolic process (GO:0044598)2.36533577
134daunorubicin metabolic process (GO:0044597)2.36533577
135regulation of mitochondrial fission (GO:0090140)2.36443594
136glycerophospholipid catabolic process (GO:0046475)2.36386587
137coenzyme catabolic process (GO:0009109)2.35422509
138glyoxylate metabolic process (GO:0046487)2.35180729
139peptidyl-histidine modification (GO:0018202)2.35088594
140ferric iron transport (GO:0015682)2.34180991
141trivalent inorganic cation transport (GO:0072512)2.34180991
142negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.33594706
143cofactor catabolic process (GO:0051187)2.33587409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.23950875
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91243191
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56205525
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.34978222
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.17905624
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.89769570
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.84789162
8EZH2_22144423_ChIP-Seq_EOC_Human2.83143706
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82825388
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74527146
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.71333487
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.69333978
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.59701408
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.59563838
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.53377239
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48515005
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46878253
18TAF15_26573619_Chip-Seq_HEK293_Human2.44005659
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35234115
20GBX2_23144817_ChIP-Seq_PC3_Human2.14482201
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.12893424
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.11746891
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07676066
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02945373
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98272655
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.97898419
27SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.97064718
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94336606
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.90716380
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.83495844
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73811018
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72668016
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72376965
34* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72188607
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69688038
36P68_20966046_ChIP-Seq_HELA_Human1.67230778
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66107289
38DCP1A_22483619_ChIP-Seq_HELA_Human1.63779857
39VDR_23849224_ChIP-Seq_CD4+_Human1.59306648
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54126898
41FOXP1_21924763_ChIP-Seq_HESCs_Human1.47658188
42IGF1R_20145208_ChIP-Seq_DFB_Human1.46649650
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.46313583
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45648188
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44637466
46BCL6_27268052_Chip-Seq_Bcells_Human1.44500206
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44048632
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.43529237
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42864136
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42482137
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42043667
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40936337
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40595138
54ERA_21632823_ChIP-Seq_H3396_Human1.38309664
55CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38055817
56LXR_22292898_ChIP-Seq_THP-1_Human1.36109199
57VDR_22108803_ChIP-Seq_LS180_Human1.35921655
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33343889
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32608763
60KDM5A_27292631_Chip-Seq_BREAST_Human1.32439484
61FOXP3_21729870_ChIP-Seq_TREG_Human1.32148511
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.31794013
63CTCF_20526341_ChIP-Seq_ESCs_Human1.31587484
64IRF1_19129219_ChIP-ChIP_H3396_Human1.30531060
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30033274
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29587255
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28728302
68ZNF263_19887448_ChIP-Seq_K562_Human1.28579967
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28021707
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26375633
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26152260
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22847781
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22320519
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21887861
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21755069
76BCOR_27268052_Chip-Seq_Bcells_Human1.21179057
77CIITA_25753668_ChIP-Seq_RAJI_Human1.20893408
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.20852846
79REST_21632747_ChIP-Seq_MESCs_Mouse1.20167050
80MYC_18940864_ChIP-ChIP_HL60_Human1.19727129
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.19717999
82PHF8_20622854_ChIP-Seq_HELA_Human1.19383109
83HTT_18923047_ChIP-ChIP_STHdh_Human1.18770343
84E2F1_20622854_ChIP-Seq_HELA_Human1.18396445
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17466942
86RACK7_27058665_Chip-Seq_MCF-7_Human1.16669665
87GABP_19822575_ChIP-Seq_HepG2_Human1.16327871
88* RARB_24833708_ChIP-Seq_LIVER_Mouse1.16013755
89RAC3_21632823_ChIP-Seq_H3396_Human1.15973834
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14938422
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13951914
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.13392542
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.13133596
94SA1_27219007_Chip-Seq_Bcells_Human1.12127938
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11192622
96CTCF_27219007_Chip-Seq_Bcells_Human1.10788920
97PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10319184
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10254386
99EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09405413
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09230070
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06796169
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06709342
103RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06456804
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04289255
105SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03885260
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03350942
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03178967
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.02886931
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01268710
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00798073
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.00491362
112* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99263164
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98809210
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.98185830
115ERG_21242973_ChIP-ChIP_JURKAT_Human0.97466685
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97315025
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96991985
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96909800
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96751714
120TTF2_22483619_ChIP-Seq_HELA_Human0.96037332
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95698584
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94722176
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94481441
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94361519
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94155610
126TFEB_21752829_ChIP-Seq_HELA_Human0.92509901
127GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92158406
128FLI1_27457419_Chip-Seq_LIVER_Mouse0.92039396
129P300_19829295_ChIP-Seq_ESCs_Human0.91363111
130SMC4_20622854_ChIP-Seq_HELA_Human0.90895606
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89957115
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89381388
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.89299966
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88580318
135EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88580318
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88000562
137ZNF274_21170338_ChIP-Seq_K562_Hela0.87390292
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.86631191
139CTCF_21964334_Chip-Seq_Bcells_Human0.86301832
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86242628
141TAF2_19829295_ChIP-Seq_ESCs_Human0.86067624
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.86012225
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85849130
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.84730343
145* XRN2_22483619_ChIP-Seq_HELA_Human0.81967764
146YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81692070
147MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81553795
148SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81056640
149ER_23166858_ChIP-Seq_MCF-7_Human0.80898760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.09873967
2MP0002837_dystrophic_cardiac_calcinosis3.66805319
3MP0003646_muscle_fatigue3.54700810
4MP0001529_abnormal_vocalization3.43633495
5MP0005360_urolithiasis2.88605904
6MP0006036_abnormal_mitochondrial_physio2.65476174
7MP0002139_abnormal_hepatobiliary_system2.65318411
8MP0008875_abnormal_xenobiotic_pharmacok2.64386643
9MP0006276_abnormal_autonomic_nervous2.37598135
10MP0005645_abnormal_hypothalamus_physiol2.36430713
11MP0005085_abnormal_gallbladder_physiolo2.33670283
12MP0001905_abnormal_dopamine_level2.25981340
13MP0009379_abnormal_foot_pigmentation2.13995695
14MP0005365_abnormal_bile_salt2.11306821
15MP0009745_abnormal_behavioral_response2.08949254
16MP0002064_seizures2.08136859
17MP0009697_abnormal_copulation2.06825248
18MP0003635_abnormal_synaptic_transmissio2.05445129
19MP0002822_catalepsy2.01808480
20MP0004142_abnormal_muscle_tone2.00807480
21MP0004215_abnormal_myocardial_fiber1.95073764
22MP0004859_abnormal_synaptic_plasticity1.92478707
23MP0000749_muscle_degeneration1.92014286
24MP0004147_increased_porphyrin_level1.91462692
25MP0000372_irregular_coat_pigmentation1.90310410
26MP0002876_abnormal_thyroid_physiology1.87271481
27MP0003195_calcinosis1.84940902
28MP0000049_abnormal_middle_ear1.83313202
29MP0001968_abnormal_touch/_nociception1.81426028
30MP0002653_abnormal_ependyma_morphology1.79138731
31MP0005670_abnormal_white_adipose1.76904443
32MP0010386_abnormal_urinary_bladder1.74324181
33MP0002272_abnormal_nervous_system1.73393438
34MP0002735_abnormal_chemical_nociception1.73095520
35MP0009780_abnormal_chondrocyte_physiolo1.72436617
36MP0001764_abnormal_homeostasis1.71919464
37MP0009046_muscle_twitch1.70294571
38MP0005332_abnormal_amino_acid1.65470945
39MP0001188_hyperpigmentation1.63409234
40MP0005083_abnormal_biliary_tract1.62625407
41MP0000751_myopathy1.61998498
42MP0005084_abnormal_gallbladder_morpholo1.59604537
43MP0005423_abnormal_somatic_nervous1.54556040
44MP0006035_abnormal_mitochondrial_morpho1.53947266
45MP0002572_abnormal_emotion/affect_behav1.53244556
46MP0003938_abnormal_ear_development1.52336919
47MP0002063_abnormal_learning/memory/cond1.52297335
48MP0004270_analgesia1.49699490
49MP0008789_abnormal_olfactory_epithelium1.49579819
50MP0003656_abnormal_erythrocyte_physiolo1.46596674
51MP0000013_abnormal_adipose_tissue1.45160644
52MP0002736_abnormal_nociception_after1.45086117
53MP0001502_abnormal_circadian_rhythm1.44380410
54MP0008260_abnormal_autophagy1.38691101
55MP0004019_abnormal_vitamin_homeostasis1.37982201
56MP0005075_abnormal_melanosome_morpholog1.36294640
57MP0002277_abnormal_respiratory_mucosa1.35411213
58MP0002102_abnormal_ear_morphology1.35307288
59MP0009840_abnormal_foam_cell1.33047668
60MP0003806_abnormal_nucleotide_metabolis1.31145316
61MP0004133_heterotaxia1.30897559
62MP0000750_abnormal_muscle_regeneration1.30248877
63MP0001664_abnormal_digestion1.30026773
64MP0001486_abnormal_startle_reflex1.29806902
65MP0002163_abnormal_gland_morphology1.29298624
66MP0006072_abnormal_retinal_apoptosis1.25909479
67MP0003172_abnormal_lysosome_physiology1.25798262
68MP0010030_abnormal_orbit_morphology1.25045058
69MP0003879_abnormal_hair_cell1.24711649
70MP0005535_abnormal_body_temperature1.24339204
71MP0004043_abnormal_pH_regulation1.22199386
72MP0004924_abnormal_behavior1.22118290
73MP0005386_behavior/neurological_phenoty1.22118290
74MP0004036_abnormal_muscle_relaxation1.22025723
75MP0005636_abnormal_mineral_homeostasis1.21398799
76MP0003329_amyloid_beta_deposits1.19534618
77MP0002734_abnormal_mechanical_nocicepti1.18238870
78MP0010329_abnormal_lipoprotein_level1.18022500
79MP0005646_abnormal_pituitary_gland1.17823495
80MP0003137_abnormal_impulse_conducting1.17012430
81MP0001944_abnormal_pancreas_morphology1.16342713
82MP0002067_abnormal_sensory_capabilities1.16092061
83MP0001970_abnormal_pain_threshold1.14480098
84MP0000026_abnormal_inner_ear1.14367137
85MP0005058_abnormal_lysosome_morphology1.13538974
86MP0003123_paternal_imprinting1.11912157
87MP0000538_abnormal_urinary_bladder1.11456483
88MP0005584_abnormal_enzyme/coenzyme_acti1.11145782
89MP0001440_abnormal_grooming_behavior1.09754277
90MP0000230_abnormal_systemic_arterial1.06307584
91MP0003786_premature_aging1.06128635
92MP0001270_distended_abdomen1.05605371
93MP0002733_abnormal_thermal_nociception1.04300930
94MP0005379_endocrine/exocrine_gland_phen1.03173146
95MP0001542_abnormal_bone_strength1.03004336
96MP0005394_taste/olfaction_phenotype1.02733978
97MP0005499_abnormal_olfactory_system1.02733978
98MP0000631_abnormal_neuroendocrine_gland1.01530119
99MP0002638_abnormal_pupillary_reflex1.01300163
100MP0000681_abnormal_thyroid_gland0.99124766
101MP0005551_abnormal_eye_electrophysiolog0.98955982
102MP0003011_delayed_dark_adaptation0.97677907
103MP0003186_abnormal_redox_activity0.97488251
104MP0005330_cardiomyopathy0.95188522
105MP0001666_abnormal_nutrient_absorption0.95059719
106MP0002249_abnormal_larynx_morphology0.93636649
107MP0002938_white_spotting0.88703422
108MP0002693_abnormal_pancreas_physiology0.86859506
109MP0002066_abnormal_motor_capabilities/c0.86360210
110MP0001501_abnormal_sleep_pattern0.85738763
111MP0008872_abnormal_physiological_respon0.84688146
112MP0001727_abnormal_embryo_implantation0.84377738
113MP0004742_abnormal_vestibular_system0.84195444
114MP0002184_abnormal_innervation0.83521963
115MP0005408_hypopigmentation0.83058330
116MP0005266_abnormal_metabolism0.82712439
117MP0001963_abnormal_hearing_physiology0.81588878
118MP0002069_abnormal_eating/drinking_beha0.81012530
119MP0000358_abnormal_cell_content/0.80251014
120MP0001756_abnormal_urination0.79645633
121MP0001348_abnormal_lacrimal_gland0.79616456
122MP0005376_homeostasis/metabolism_phenot0.79171803
123MP0001984_abnormal_olfaction0.78763584
124MP0002078_abnormal_glucose_homeostasis0.78724110
125MP0000778_abnormal_nervous_system0.77983569
126MP0002332_abnormal_exercise_endurance0.77980170
127MP0002177_abnormal_outer_ear0.77917465
128MP0000427_abnormal_hair_cycle0.75843168
129MP0005319_abnormal_enzyme/_coenzyme0.75367468
130MP0002972_abnormal_cardiac_muscle0.74978628
131MP0002970_abnormal_white_adipose0.74324952
132MP0003122_maternal_imprinting0.74148222
133MP0004145_abnormal_muscle_electrophysio0.73151285
134MP0005310_abnormal_salivary_gland0.73083245
135MP0002557_abnormal_social/conspecific_i0.72871664
136MP0001346_abnormal_lacrimal_gland0.72545130
137MP0008004_abnormal_stomach_pH0.72407376
138MP0005220_abnormal_exocrine_pancreas0.72350798
139MP0005367_renal/urinary_system_phenotyp0.72084149
140MP0000516_abnormal_urinary_system0.72084149
141MP0004233_abnormal_muscle_weight0.72074503
142MP0005620_abnormal_muscle_contractility0.71884124
143MP0002118_abnormal_lipid_homeostasis0.71020105
144MP0008569_lethality_at_weaning0.70621283
145MP0004484_altered_response_of0.69895273
146MP0002909_abnormal_adrenal_gland0.69800831
147MP0001765_abnormal_ion_homeostasis0.69369357
148MP0005448_abnormal_energy_balance0.68952236
149MP0004085_abnormal_heartbeat0.68486753
150MP0005451_abnormal_body_composition0.67435097
151MP0001663_abnormal_digestive_system0.66230033

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.26651448
2Abnormal mitochondria in muscle tissue (HP:0008316)5.94126799
3Mitochondrial inheritance (HP:0001427)5.87094747
4Hepatocellular necrosis (HP:0001404)5.66564182
5Acute encephalopathy (HP:0006846)5.57416569
6Progressive macrocephaly (HP:0004481)5.46871579
7Hepatic necrosis (HP:0002605)5.15544990
8Increased CSF lactate (HP:0002490)5.04155430
9Cerebral edema (HP:0002181)4.43535486
10Lactic acidosis (HP:0003128)3.96185204
11Fibular aplasia (HP:0002990)3.87219508
12Increased hepatocellular lipid droplets (HP:0006565)3.83610478
13Lipid accumulation in hepatocytes (HP:0006561)3.83102643
14Increased serum lactate (HP:0002151)3.61483705
15Renal Fanconi syndrome (HP:0001994)3.60821657
16Optic disc pallor (HP:0000543)3.58322024
17Focal motor seizures (HP:0011153)3.56440313
18Respiratory failure (HP:0002878)3.56045887
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.53991588
20Increased intramyocellular lipid droplets (HP:0012240)3.51248765
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.42868241
22Hyperventilation (HP:0002883)3.39220044
23Exercise intolerance (HP:0003546)3.35998234
24Increased muscle lipid content (HP:0009058)3.33776075
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.26865105
26Decreased activity of mitochondrial respiratory chain (HP:0008972)3.26865105
27Microretrognathia (HP:0000308)3.17550558
283-Methylglutaconic aciduria (HP:0003535)3.15253236
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13852952
30Abnormality of glycolysis (HP:0004366)3.07516764
31Increased serum pyruvate (HP:0003542)3.07516764
32Aplasia/hypoplasia of the uterus (HP:0008684)3.04978135
33Lethargy (HP:0001254)2.89067383
34Concave nail (HP:0001598)2.86843012
35Leukodystrophy (HP:0002415)2.85852911
36Neuroendocrine neoplasm (HP:0100634)2.83954357
37CNS demyelination (HP:0007305)2.79320175
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73599477
39Limb dystonia (HP:0002451)2.65471473
40Abnormality of renal resorption (HP:0011038)2.64808769
41Prolonged neonatal jaundice (HP:0006579)2.61286159
42Pheochromocytoma (HP:0002666)2.55783465
43Delayed CNS myelination (HP:0002188)2.51291860
44Glycosuria (HP:0003076)2.50846685
45Abnormality of urine glucose concentration (HP:0011016)2.50846685
46Emotional lability (HP:0000712)2.50403084
47Esophageal neoplasm (HP:0100751)2.48111789
48Neoplasm of head and neck (HP:0012288)2.48111789
49Aplasia/Hypoplasia of the patella (HP:0006498)2.47257916
50Exertional dyspnea (HP:0002875)2.44947945
51Testicular atrophy (HP:0000029)2.43516115
52Patellar aplasia (HP:0006443)2.42108287
53Type I transferrin isoform profile (HP:0003642)2.41255891
54Gait imbalance (HP:0002141)2.38260394
55Dicarboxylic aciduria (HP:0003215)2.35750850
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35750850
57Methylmalonic aciduria (HP:0012120)2.29884771
58Respiratory difficulties (HP:0002880)2.29321854
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.29086150
60Abnormality of alanine metabolism (HP:0010916)2.29086150
61Hyperalaninemia (HP:0003348)2.29086150
62Pancreatic cysts (HP:0001737)2.28687382
63Ketosis (HP:0001946)2.28002529
64X-linked dominant inheritance (HP:0001423)2.26393281
65Hyperphosphaturia (HP:0003109)2.26388135
66Myokymia (HP:0002411)2.26359448
67Gout (HP:0001997)2.23645436
68Congenital primary aphakia (HP:0007707)2.23462320
69Molar tooth sign on MRI (HP:0002419)2.23057846
70Abnormality of midbrain morphology (HP:0002418)2.23057846
71Abnormal number of erythroid precursors (HP:0012131)2.21749616
72Ragged-red muscle fibers (HP:0003200)2.20181144
73Microvesicular hepatic steatosis (HP:0001414)2.19898979
74Medial flaring of the eyebrow (HP:0010747)2.17683191
75Vomiting (HP:0002013)2.17226759
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14488232
77Nephrogenic diabetes insipidus (HP:0009806)2.14034434
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.13610663
79Abnormality of fatty-acid metabolism (HP:0004359)2.11755040
80Severe muscular hypotonia (HP:0006829)2.08911196
81Agitation (HP:0000713)2.08120777
82Cholecystitis (HP:0001082)2.07486634
83Abnormal gallbladder physiology (HP:0012438)2.07486634
84Poor suck (HP:0002033)2.06519539
85Shawl scrotum (HP:0000049)2.04810176
86Epileptic encephalopathy (HP:0200134)2.04277718
87Abnormality of cells of the erythroid lineage (HP:0012130)2.03756633
88Metabolic acidosis (HP:0001942)2.03582949
89Calf muscle hypertrophy (HP:0008981)2.03374320
90Prolonged partial thromboplastin time (HP:0003645)2.03169192
91Generalized aminoaciduria (HP:0002909)2.02953515
92Abnormal rod and cone electroretinograms (HP:0008323)2.02779268
93Ketoacidosis (HP:0001993)2.02157772
94Muscle hypertrophy of the lower extremities (HP:0008968)2.02032168
95Brushfield spots (HP:0001088)1.99617517
96Oligodactyly (hands) (HP:0001180)1.99359753
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96722015
98Abnormal protein N-linked glycosylation (HP:0012347)1.96722015
99Abnormal protein glycosylation (HP:0012346)1.96722015
100Abnormal glycosylation (HP:0012345)1.96722015
101Hypokinesia (HP:0002375)1.96339254
102Oligomenorrhea (HP:0000876)1.96188833
103Congenital stationary night blindness (HP:0007642)1.94789197
104Hypothermia (HP:0002045)1.93537537
105Methylmalonic acidemia (HP:0002912)1.89483469
106Gliosis (HP:0002171)1.89196121
107Diminished movement (HP:0002374)1.87768554
108Athetosis (HP:0002305)1.87657206
109Delayed gross motor development (HP:0002194)1.87491562
110Vacuolated lymphocytes (HP:0001922)1.86993193
111Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86551186
112Type II lissencephaly (HP:0007260)1.84955954
113Abnormal urine phosphate concentration (HP:0012599)1.84103048
114Hyperammonemia (HP:0001987)1.82431197
115Oligodactyly (HP:0012165)1.82076367
116Hyperglycinemia (HP:0002154)1.81232574
117Unsteady gait (HP:0002317)1.81200810
118Carpal bone hypoplasia (HP:0001498)1.80014638
119Anxiety (HP:0000739)1.78184922
120Muscular hypotonia of the trunk (HP:0008936)1.77812480
121Conjunctival hamartoma (HP:0100780)1.77608772
122Visual hallucinations (HP:0002367)1.77172373
123Atonic seizures (HP:0010819)1.76824754
124Hypobetalipoproteinemia (HP:0003563)1.76756312
125Delayed myelination (HP:0012448)1.76403838
126Cerebral hypomyelination (HP:0006808)1.76049909
127Flat capital femoral epiphysis (HP:0003370)1.75652811
128Delusions (HP:0000746)1.73690770
129Abnormality of serine family amino acid metabolism (HP:0010894)1.73459455
130Abnormality of glycine metabolism (HP:0010895)1.73459455
131Irregular epiphyses (HP:0010582)1.73225833
132Hyperglycinuria (HP:0003108)1.72903286
133Abnormality of serum amino acid levels (HP:0003112)1.72883127
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71985001
135Opisthotonus (HP:0002179)1.71235367
136Palpitations (HP:0001962)1.69644786
137Focal dystonia (HP:0004373)1.69298411
138Pendular nystagmus (HP:0012043)1.68530936
139Abnormal gallbladder morphology (HP:0012437)1.68200933
140Disproportionate short-trunk short stature (HP:0003521)1.67008987
141Abnormality of glycolipid metabolism (HP:0010969)1.66845876
142Abnormality of liposaccharide metabolism (HP:0010968)1.66845876
143Abnormality of glycosphingolipid metabolism (HP:0004343)1.66845876
144Humeroradial synostosis (HP:0003041)1.65336742
145Synostosis involving the elbow (HP:0003938)1.65336742
146Cholelithiasis (HP:0001081)1.63049280
147Polyphagia (HP:0002591)1.60620480
148Cerebral hemorrhage (HP:0001342)1.60375069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.65179612
2CASK3.54554061
3STK163.35078020
4VRK23.26681211
5NME23.14658728
6BCKDK2.97609137
7CDK192.84704686
8MAPKAPK32.75997014
9NME12.61797066
10MYLK2.60286175
11EIF2AK12.59098417
12ARAF2.58786736
13TESK12.53982140
14MUSK2.22744489
15MAP2K72.05722807
16EPHA21.97565513
17TLK11.92462145
18TESK21.91187805
19EPHA41.83840809
20TNIK1.69669210
21SIK11.64945359
22OXSR11.62344731
23TRIM281.61264571
24PRKD31.55376393
25BRAF1.53377779
26PDK21.50672579
27PIM21.49345325
28MAP3K91.49276184
29SIK21.45701797
30CCNB11.44658599
31DAPK11.43098526
32GRK71.40191935
33MINK11.37271767
34TRIB31.35142927
35SRPK11.34745550
36TAOK31.34741730
37MAP3K111.32850928
38PRKD21.29055559
39WNK41.27242765
40PRKCI1.26832746
41ILK1.26827769
42VRK11.26602863
43RIPK41.25436341
44PAK31.25057870
45OBSCN1.24641748
46MAP2K41.24457802
47MAP3K41.20231226
48SIK31.19306778
49NTRK31.17775723
50CAMKK21.16783968
51GRK51.14495437
52NUAK11.09470964
53NEK91.07138257
54GRK11.02792020
55EIF2AK31.00072480
56PINK10.98559895
57STK390.95928455
58BUB10.95129668
59TAOK10.93889200
60IRAK40.93768390
61PLK20.93438781
62DAPK20.92353391
63TBK10.91734032
64PRKCG0.89373360
65PIK3CG0.88917840
66DAPK30.86479001
67CSNK1G20.83854044
68BCR0.82756962
69PAK60.82218719
70ADRBK20.82066647
71CAMK2A0.81398453
72PKN10.81271440
73BMPR20.80023293
74CSNK1A1L0.79047611
75MST40.79030374
76FES0.75106381
77CAMK2D0.74081132
78SMG10.73519310
79TAOK20.72485667
80TEC0.71492308
81PDK30.71063173
82PDK40.71063173
83RPS6KA50.70090350
84RPS6KA20.70046864
85CAMK2B0.69825030
86ABL20.69409398
87PBK0.68484440
88AURKA0.68020111
89EPHB20.67883047
90LIMK10.67757752
91IKBKB0.66120654
92CAMK10.65169762
93WNK30.64609947
94CAMK2G0.63021999
95PNCK0.62864831
96CHEK20.62561983
97ADRBK10.62451462
98CDK140.61007612
99PRPF4B0.60486584
100MAP3K50.58546677
101CDK80.58116160
102PTK2B0.57487583
103PRKCE0.57310860
104CDK180.56592621
105MAPKAPK20.53752751
106MKNK20.52666585
107SYK0.52426539
108CSNK1G30.51940097
109MAPK130.51821719
110RPS6KL10.51686192
111RPS6KC10.51686192
112PRKD10.51385118
113AKT30.50970496
114CHUK0.50356831
115HIPK20.49957088
116MAP3K30.49479512
117UHMK10.49423557
118IRAK30.49273848
119STK38L0.48618044
120PHKG10.48298327
121PHKG20.48298327
122CSNK1G10.48090478
123CDK11A0.47704138
124CDK150.47059356
125PKN20.46800208
126RPS6KA60.46410043
127FRK0.44996522
128PRKACA0.44240501
129ZAK0.44195884
130PRKCZ0.43497121
131CDK50.43491631
132MARK10.43298116
133CSNK1A10.42435676
134MAP2K20.41384303
135MAPK40.39875541
136CAMKK10.39399019
137NEK10.39358759
138BRSK10.39139619
139PAK10.38838189
140DYRK20.38231314
141MAP2K60.38069092
142MAPKAPK50.36083992
143CLK10.35770532
144BRD40.35749840
145PRKCQ0.33770621
146TIE10.33175203

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.38942592
2Parkinsons disease_Homo sapiens_hsa050124.68221559
3Alzheimers disease_Homo sapiens_hsa050103.43215103
4Huntingtons disease_Homo sapiens_hsa050163.10611751
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.88467693
6Protein export_Homo sapiens_hsa030602.55225733
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42332311
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.39974155
9Cardiac muscle contraction_Homo sapiens_hsa042602.39217376
10Ribosome_Homo sapiens_hsa030102.33757157
11Proteasome_Homo sapiens_hsa030502.25757521
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.04369224
13Collecting duct acid secretion_Homo sapiens_hsa049661.96309720
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93345101
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84897378
16Propanoate metabolism_Homo sapiens_hsa006401.84307232
17RNA polymerase_Homo sapiens_hsa030201.81915420
18Fatty acid elongation_Homo sapiens_hsa000621.72897636
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66729618
20Synaptic vesicle cycle_Homo sapiens_hsa047211.66384845
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.64693779
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61164095
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58991653
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55427029
25Pyruvate metabolism_Homo sapiens_hsa006201.54606357
26Butanoate metabolism_Homo sapiens_hsa006501.52728479
27Nicotine addiction_Homo sapiens_hsa050331.51601727
28Vibrio cholerae infection_Homo sapiens_hsa051101.39188818
29Sulfur metabolism_Homo sapiens_hsa009201.33298055
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.31110306
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26809830
32Folate biosynthesis_Homo sapiens_hsa007901.26616658
33Peroxisome_Homo sapiens_hsa041461.26480747
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26081061
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.24304646
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.23701794
37Carbon metabolism_Homo sapiens_hsa012001.17366998
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13503780
39Selenocompound metabolism_Homo sapiens_hsa004501.11933284
40Fatty acid degradation_Homo sapiens_hsa000711.08291408
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07312863
42Pyrimidine metabolism_Homo sapiens_hsa002401.03783839
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01890529
44Basal transcription factors_Homo sapiens_hsa030221.01475416
45Galactose metabolism_Homo sapiens_hsa000521.00200977
46Metabolic pathways_Homo sapiens_hsa011000.99038526
47Homologous recombination_Homo sapiens_hsa034400.97228906
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95637170
49GABAergic synapse_Homo sapiens_hsa047270.93531633
50Sulfur relay system_Homo sapiens_hsa041220.92908606
51Histidine metabolism_Homo sapiens_hsa003400.91476256
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.88473858
53Tryptophan metabolism_Homo sapiens_hsa003800.86158147
54Biosynthesis of amino acids_Homo sapiens_hsa012300.85313670
55Caffeine metabolism_Homo sapiens_hsa002320.85074289
56Arginine and proline metabolism_Homo sapiens_hsa003300.81029248
57beta-Alanine metabolism_Homo sapiens_hsa004100.79613049
58Fatty acid biosynthesis_Homo sapiens_hsa000610.79353396
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78703304
60Phenylalanine metabolism_Homo sapiens_hsa003600.77232125
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77044969
62Fatty acid metabolism_Homo sapiens_hsa012120.76032593
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75122997
64One carbon pool by folate_Homo sapiens_hsa006700.74025339
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73045890
66N-Glycan biosynthesis_Homo sapiens_hsa005100.72864228
67Amphetamine addiction_Homo sapiens_hsa050310.72849781
68Morphine addiction_Homo sapiens_hsa050320.71840230
69Lysosome_Homo sapiens_hsa041420.70849582
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.70728380
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69898485
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69308754
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.67136361
74Purine metabolism_Homo sapiens_hsa002300.66854277
75Steroid biosynthesis_Homo sapiens_hsa001000.64006487
76Arginine biosynthesis_Homo sapiens_hsa002200.63800748
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62363421
78Tyrosine metabolism_Homo sapiens_hsa003500.61268935
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60200740
80Serotonergic synapse_Homo sapiens_hsa047260.59850940
81Dopaminergic synapse_Homo sapiens_hsa047280.59596485
82Taste transduction_Homo sapiens_hsa047420.57318747
83Phototransduction_Homo sapiens_hsa047440.56625783
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56048197
85Vitamin B6 metabolism_Homo sapiens_hsa007500.55048753
86Starch and sucrose metabolism_Homo sapiens_hsa005000.54618750
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53887005
88Sphingolipid metabolism_Homo sapiens_hsa006000.53767907
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53354647
90Circadian entrainment_Homo sapiens_hsa047130.51060591
91Olfactory transduction_Homo sapiens_hsa047400.49107523
92Glutathione metabolism_Homo sapiens_hsa004800.49064324
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45609055
94Chemical carcinogenesis_Homo sapiens_hsa052040.44853218
95Insulin secretion_Homo sapiens_hsa049110.44813172
96Regulation of autophagy_Homo sapiens_hsa041400.42477626
97Calcium signaling pathway_Homo sapiens_hsa040200.41159603
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40035384
99Cocaine addiction_Homo sapiens_hsa050300.36845632
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35915493
101PPAR signaling pathway_Homo sapiens_hsa033200.35479913
102Glutamatergic synapse_Homo sapiens_hsa047240.35048667
103Epstein-Barr virus infection_Homo sapiens_hsa051690.33539519
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31945534
105Rheumatoid arthritis_Homo sapiens_hsa053230.31935850
106Fructose and mannose metabolism_Homo sapiens_hsa000510.31890253
107Cholinergic synapse_Homo sapiens_hsa047250.31637615
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31507630
109Retinol metabolism_Homo sapiens_hsa008300.31305789
110Long-term potentiation_Homo sapiens_hsa047200.31239104
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31090750
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31047533
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30845672
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29713527
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25983920
116Pentose phosphate pathway_Homo sapiens_hsa000300.25461709
117Complement and coagulation cascades_Homo sapiens_hsa046100.24807388
118Other glycan degradation_Homo sapiens_hsa005110.24653173
119Base excision repair_Homo sapiens_hsa034100.24150236
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23318895
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22521837
122Mismatch repair_Homo sapiens_hsa034300.17719769
123DNA replication_Homo sapiens_hsa030300.16852594

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