DNAJC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.03787624
2sperm motility (GO:0030317)6.48187032
3acrosome reaction (GO:0007340)5.80437728
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.62077807
5ATP synthesis coupled proton transport (GO:0015986)5.51470922
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51470922
7sperm capacitation (GO:0048240)5.35284084
8plasma membrane fusion (GO:0045026)5.26698895
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.25497099
10tricarboxylic acid cycle (GO:0006099)5.11692600
11respiratory electron transport chain (GO:0022904)4.91161895
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.88966770
13phosphatidylethanolamine biosynthetic process (GO:0006646)4.86243054
14electron transport chain (GO:0022900)4.76080276
15phosphatidylethanolamine metabolic process (GO:0046337)4.39876849
16NADH metabolic process (GO:0006734)4.36831633
17sarcomere organization (GO:0045214)4.36383315
18sexual reproduction (GO:0019953)4.34967416
19oxidative phosphorylation (GO:0006119)4.32654278
20regulation of T-helper 2 cell differentiation (GO:0045628)4.26069998
21multicellular organism reproduction (GO:0032504)4.00289452
22spermatid development (GO:0007286)3.97965345
23reproduction (GO:0000003)3.94702028
24heart process (GO:0003015)3.92386773
25heart contraction (GO:0060047)3.92386773
26protein targeting to Golgi (GO:0000042)3.87098406
27immunoglobulin mediated immune response (GO:0016064)3.81338760
28retrograde transport, vesicle recycling within Golgi (GO:0000301)3.79371473
29ATP biosynthetic process (GO:0006754)3.73086915
30cytidine deamination (GO:0009972)3.70781113
31cytidine metabolic process (GO:0046087)3.70781113
32cytidine catabolic process (GO:0006216)3.70781113
33quinone biosynthetic process (GO:1901663)3.69542545
34ubiquinone biosynthetic process (GO:0006744)3.69542545
35positive regulation of type 2 immune response (GO:0002830)3.67153267
36positive regulation by symbiont of host defense response (GO:0052509)3.65110173
37modulation by symbiont of host defense response (GO:0052031)3.65110173
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65110173
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65110173
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.65110173
41modulation by symbiont of host immune response (GO:0052553)3.65110173
42spermatid nucleus differentiation (GO:0007289)3.64217455
43establishment of protein localization to Golgi (GO:0072600)3.57440773
44chromosome condensation (GO:0030261)3.53903865
45muscle filament sliding (GO:0030049)3.50334631
46actin-myosin filament sliding (GO:0033275)3.50334631
47sperm-egg recognition (GO:0035036)3.46955577
48succinate metabolic process (GO:0006105)3.46276056
49DNA packaging (GO:0006323)3.44449283
50negative regulation of inclusion body assembly (GO:0090084)3.42422692
51oxaloacetate metabolic process (GO:0006107)3.41632587
52protein polyglutamylation (GO:0018095)3.38951561
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.38143877
54purine nucleoside triphosphate biosynthetic process (GO:0009145)3.37902164
55negative regulation of erythrocyte differentiation (GO:0045647)3.37230426
56signal peptide processing (GO:0006465)3.36216647
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.34982634
58peptide catabolic process (GO:0043171)3.32273781
59regulation of sequestering of triglyceride (GO:0010889)3.29817783
60sequestering of actin monomers (GO:0042989)3.28536028
61myofibril assembly (GO:0030239)3.26749972
62cell wall macromolecule catabolic process (GO:0016998)3.26745080
63fatty acid beta-oxidation (GO:0006635)3.23052541
64rRNA methylation (GO:0031167)3.21166812
65negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.17448670
66regulation of Rab GTPase activity (GO:0032313)3.15507622
67positive regulation of Rab GTPase activity (GO:0032851)3.15507622
68cell wall macromolecule metabolic process (GO:0044036)3.13762699
69hydrogen ion transmembrane transport (GO:1902600)3.11663343
70RNA destabilization (GO:0050779)3.11482339
71cardiac myofibril assembly (GO:0055003)3.11171235
72macrophage activation involved in immune response (GO:0002281)3.09304807
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07965147
74single strand break repair (GO:0000012)3.07494833
75negative regulation of cell killing (GO:0031342)3.03983903
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03983903
77calcium ion-dependent exocytosis (GO:0017156)3.02933216
78ubiquinone metabolic process (GO:0006743)3.02908473
79cell-cell recognition (GO:0009988)3.01720054
80valine metabolic process (GO:0006573)3.00613922
81ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00242260
82positive regulation of gamma-delta T cell activation (GO:0046645)2.99893550
83regulation of mast cell degranulation (GO:0043304)2.98304958
84detection of bacterium (GO:0016045)2.96802164
85spermatogenesis (GO:0007283)2.96391722
86response to pheromone (GO:0019236)2.94694402
87carnitine shuttle (GO:0006853)2.94183832
88male gamete generation (GO:0048232)2.93878064
89microtubule severing (GO:0051013)2.93359826
90negative regulation of granulocyte differentiation (GO:0030853)2.91723627
91regulation of oxidative phosphorylation (GO:0002082)2.86615010
92protein localization to Golgi apparatus (GO:0034067)2.84556360
93antigen processing and presentation of endogenous antigen (GO:0019883)2.83757546
94response to host immune response (GO:0052572)2.83669575
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83669575
96fatty acid catabolic process (GO:0009062)2.83528290
97cellular response to zinc ion (GO:0071294)2.83504299
98hydrogen peroxide biosynthetic process (GO:0050665)2.82814917
99regulation of gamma-delta T cell activation (GO:0046643)2.82765100
100branched-chain amino acid catabolic process (GO:0009083)2.82751882
101fatty acid transmembrane transport (GO:1902001)2.82371144
102regulation of ARF GTPase activity (GO:0032312)2.81911868
103regulation of mast cell activation involved in immune response (GO:0033006)2.81594407
104NIK/NF-kappaB signaling (GO:0038061)2.81232152
105detection of other organism (GO:0098543)2.80674090
106actin-mediated cell contraction (GO:0070252)2.79704890
107neutrophil activation involved in immune response (GO:0002283)2.79352584
108myeloid cell activation involved in immune response (GO:0002275)2.78183818
109regulation of skeletal muscle contraction (GO:0014819)2.78018590
110protein complex biogenesis (GO:0070271)2.77743010
111proton transport (GO:0015992)2.77461351
112axonemal dynein complex assembly (GO:0070286)2.77270786
1132-oxoglutarate metabolic process (GO:0006103)2.76627677
114binding of sperm to zona pellucida (GO:0007339)2.75713258
115mitochondrial calcium ion transport (GO:0006851)2.74717871
116regulation of relaxation of muscle (GO:1901077)2.73906157
117mature B cell differentiation involved in immune response (GO:0002313)2.73310307
118regulation of interferon-beta biosynthetic process (GO:0045357)2.72390212
119nucleoside triphosphate biosynthetic process (GO:0009142)2.72108077
120hydrogen transport (GO:0006818)2.71670957
121membrane protein intracellular domain proteolysis (GO:0031293)2.70759311
122L-methionine salvage (GO:0071267)2.70566909
123L-methionine biosynthetic process (GO:0071265)2.70566909
124amino acid salvage (GO:0043102)2.70566909
125interferon-gamma-mediated signaling pathway (GO:0060333)2.70431110
126ADP metabolic process (GO:0046031)2.69730336
127positive regulation of mast cell activation (GO:0033005)2.67784293
128cardiac muscle cell development (GO:0055013)2.67720092
129regulation of cilium movement (GO:0003352)2.67460388
130single fertilization (GO:0007338)2.66643749
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.66070871
132positive regulation of mast cell degranulation (GO:0043306)2.66070871
133branched-chain amino acid metabolic process (GO:0009081)2.65964206
134response to peptidoglycan (GO:0032494)2.65875042
135cardiac muscle tissue morphogenesis (GO:0055008)2.65528975
136gamete generation (GO:0007276)2.64670976
137mitochondrial respiratory chain complex I assembly (GO:0032981)2.64171784
138NADH dehydrogenase complex assembly (GO:0010257)2.64171784
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64171784
140fatty acid oxidation (GO:0019395)2.63751789
141negative regulation of potassium ion transmembrane transport (GO:1901380)2.63617172
142regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.63244565
143cardiac muscle contraction (GO:0060048)2.62846823
144reactive oxygen species biosynthetic process (GO:1903409)2.62548780
145lipid oxidation (GO:0034440)2.62545828
146regulation of gamma-delta T cell differentiation (GO:0045586)2.62334304
147rRNA modification (GO:0000154)2.62216035
148regulation of type 2 immune response (GO:0002828)2.61816829
149positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.61691041
150cellular ketone body metabolic process (GO:0046950)2.60480144
151response to acidic pH (GO:0010447)2.60269849
152purine nucleoside monophosphate biosynthetic process (GO:0009127)2.59732091
153purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.59732091
154polyamine biosynthetic process (GO:0006596)2.59278866
155response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59151551
156response to host (GO:0075136)2.59151551
157response to host defenses (GO:0052200)2.59151551
158regulation of mitochondrial translation (GO:0070129)2.58777416
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.57869455
160positive regulation of T-helper cell differentiation (GO:0045624)2.56782413
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55215043
162antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55081814
163aerobic respiration (GO:0009060)2.54662401
164ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.54617446
165regulation of inclusion body assembly (GO:0090083)2.54020194
166positive regulation of antigen processing and presentation (GO:0002579)2.53548999
167carnitine transmembrane transport (GO:1902603)2.53435706
168B cell mediated immunity (GO:0019724)2.51966115
169positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51581899
170mitochondrion degradation (GO:0000422)2.51527165
171antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51288043
172antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51288043
173cardiac cell development (GO:0055006)2.50496216
174antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.49639365
175cellular response to pH (GO:0071467)2.49534593
176cytochrome complex assembly (GO:0017004)2.48837185
177microtubule depolymerization (GO:0007019)2.48797790
178biotin metabolic process (GO:0006768)2.47787716
179mast cell activation (GO:0045576)2.45819153
180leukocyte degranulation (GO:0043299)2.45479840
181mitochondrial respiratory chain complex assembly (GO:0033108)2.45467858
182positive regulation of interleukin-4 production (GO:0032753)2.44949044
183regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.44442718
184regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43649169
185amino-acid betaine transport (GO:0015838)2.42605647
186carnitine transport (GO:0015879)2.42605647
187cellular response to nicotine (GO:0071316)2.40259814
188mitochondrial transport (GO:0006839)2.38388701
189regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.38302731
190ventricular cardiac muscle cell action potential (GO:0086005)2.38176447
191ribonucleoside monophosphate biosynthetic process (GO:0009156)2.34072713
192myeloid dendritic cell differentiation (GO:0043011)2.34048711
193tricarboxylic acid metabolic process (GO:0072350)2.33989975
194actomyosin structure organization (GO:0031032)2.33449225
195heart trabecula formation (GO:0060347)2.31736219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47333590
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.77873993
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.96432341
4LXR_22292898_ChIP-Seq_THP-1_Human2.87184129
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72689611
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68400138
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.67603591
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65999750
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59908243
10* SRF_21415370_ChIP-Seq_HL-1_Mouse2.56654652
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44953048
12ELF1_20517297_ChIP-Seq_JURKAT_Human2.44905198
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43419838
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35602337
15* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.35397438
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30456084
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.27533545
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25160460
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.25068323
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18584638
21P68_20966046_ChIP-Seq_HELA_Human2.18130653
22VDR_21846776_ChIP-Seq_THP-1_Human2.16186237
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.15313110
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03512661
25* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.02424631
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01168815
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95722059
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.94883865
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94748174
30VDR_24763502_ChIP-Seq_THP-1_Human1.93726638
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89571851
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88367167
33SPI1_23127762_ChIP-Seq_K562_Human1.82384770
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81263740
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80755396
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.80659033
37SMC4_20622854_ChIP-Seq_HELA_Human1.79862808
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.79269549
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77686581
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.69719481
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.69435932
42TCF7_22412390_ChIP-Seq_EML_Mouse1.69156300
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68996039
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68619597
45E2F1_20622854_ChIP-Seq_HELA_Human1.68475892
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66354208
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.65545808
48* SA1_27219007_Chip-Seq_ERYTHROID_Human1.63806578
49PHF8_20622854_ChIP-Seq_HELA_Human1.63631562
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.62722778
51* KDM2B_26808549_Chip-Seq_DND41_Human1.61446422
52SCL_19346495_ChIP-Seq_HPC-7_Human1.61363035
53UTX_26944678_Chip-Seq_JUKART_Human1.60894707
54MAF_26560356_Chip-Seq_TH1_Human1.60535591
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58397954
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58334513
57* CTCF_27219007_Chip-Seq_Bcells_Human1.58026425
58VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.56788752
59MAF_26560356_Chip-Seq_TH2_Human1.56048336
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.53695005
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53689243
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52854565
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52576192
64RUNX_20019798_ChIP-Seq_JUKART_Human1.50706219
65BCL6_27268052_Chip-Seq_Bcells_Human1.50681389
66CTCF_20526341_ChIP-Seq_ESCs_Human1.48896520
67P300_27268052_Chip-Seq_Bcells_Human1.48729012
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48409764
69MYC_22102868_ChIP-Seq_BL_Human1.47692766
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47665110
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46101829
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46099667
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44414053
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.43963031
75TP63_22573176_ChIP-Seq_HFKS_Human1.43653946
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43018472
77SA1_27219007_Chip-Seq_Bcells_Human1.42557013
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42527986
79RAC3_21632823_ChIP-Seq_H3396_Human1.39366821
80* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37639018
81SPI1_20517297_ChIP-Seq_HL60_Human1.37462492
82GATA1_19941826_ChIP-Seq_K562_Human1.37239998
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.36961433
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36884663
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36248817
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34427050
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33329084
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33311600
89DROSHA_22980978_ChIP-Seq_HELA_Human1.32116983
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30827430
91ERA_21632823_ChIP-Seq_H3396_Human1.30661532
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.30064575
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30054189
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28743602
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.28412629
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.27998845
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.27998845
98DCP1A_22483619_ChIP-Seq_HELA_Human1.27336805
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26908220
100NANOG_20526341_ChIP-Seq_ESCs_Human1.26549458
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26344276
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26122671
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25656926
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25416546
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24287382
106VDR_23849224_ChIP-Seq_CD4+_Human1.24180062
107CTCF_21964334_Chip-Seq_Bcells_Human1.24158799
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23072899
109E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22830250
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22096269
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22048883
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.20468525
113RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19536552
114RACK7_27058665_Chip-Seq_MCF-7_Human1.19343304
115TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17154407
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16369171
117MYB_26560356_Chip-Seq_TH2_Human1.16082514
118MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15925242
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15621285
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14287532
121BCOR_27268052_Chip-Seq_Bcells_Human1.13840906
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13119841
123GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12624233
124NCOR1_26117541_ChIP-Seq_K562_Human1.12269524
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12260126
126* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12144178
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11491887
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11456763
129* TAF2_19829295_ChIP-Seq_ESCs_Human1.10785970
130* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09931258
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08822974
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08039756
133OCT4_19829295_ChIP-Seq_ESCs_Human1.07878358
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07442297
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07248505
136SPI1_23547873_ChIP-Seq_NB4_Human1.07075888
137GATA1_22025678_ChIP-Seq_K562_Human1.06656490
138OCT4_20526341_ChIP-Seq_ESCs_Human1.05438493
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05056343
140TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04108098
141CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03570494
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03544551
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03543623
144PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03333366
145SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03072759
146RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01999189
147* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01986737
148MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01929863
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01817781
150GATA3_21867929_ChIP-Seq_CD8_Mouse1.01088665
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00664830
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00107727
153NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99979800
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99835657
155ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99007436
156PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98300546
157KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96219584
158CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95657357
159* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95078695
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95037497
161STAT1_20625510_ChIP-Seq_HELA_Human0.95006460
162GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94989347
163HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93846314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.46954999
2MP0003646_muscle_fatigue4.42379845
3MP0004084_abnormal_cardiac_muscle3.28092671
4MP0004215_abnormal_myocardial_fiber2.85857586
5MP0003303_peritoneal_inflammation2.75377725
6MP0000749_muscle_degeneration2.68091093
7MP0005377_hearing/vestibular/ear_phenot2.62372089
8MP0003878_abnormal_ear_physiology2.62372089
9MP0004036_abnormal_muscle_relaxation2.57115975
10MP0001835_abnormal_antigen_presentation2.54962448
11MP0003806_abnormal_nucleotide_metabolis2.50537658
12MP0006036_abnormal_mitochondrial_physio2.45612106
13MP0000751_myopathy2.36482616
14MP0005330_cardiomyopathy2.31786297
15MP0005464_abnormal_platelet_physiology2.28767237
16MP0002132_abnormal_respiratory_system2.27070357
17MP0003436_decreased_susceptibility_to2.25679642
18MP0002148_abnormal_hypersensitivity_rea2.20073460
19MP0003172_abnormal_lysosome_physiology2.13816820
20MP0005670_abnormal_white_adipose2.05326581
21MP0002972_abnormal_cardiac_muscle2.04396252
22MP0009278_abnormal_bone_marrow1.93768350
23MP0009785_altered_susceptibility_to1.91392706
24MP0005410_abnormal_fertilization1.90669090
25MP0004510_myositis1.90602382
26MP0003186_abnormal_redox_activity1.88076403
27MP0000750_abnormal_muscle_regeneration1.84043095
28MP0003698_abnormal_male_reproductive1.83840752
29MP0000685_abnormal_immune_system1.78668450
30MP0004130_abnormal_muscle_cell1.71217949
31MP0004087_abnormal_muscle_fiber1.67586408
32MP0008775_abnormal_heart_ventricle1.66539497
33MP0000678_abnormal_parathyroid_gland1.66091896
34MP0001544_abnormal_cardiovascular_syste1.65896508
35MP0005385_cardiovascular_system_phenoty1.65896508
36MP0003828_pulmonary_edema1.65139347
37MP0003191_abnormal_cellular_cholesterol1.58891157
38MP0005025_abnormal_response_to1.55546632
39MP0002139_abnormal_hepatobiliary_system1.53173949
40MP0005058_abnormal_lysosome_morphology1.51952518
41MP0000343_altered_response_to1.51737988
42MP0005671_abnormal_response_to1.49805974
43MP0001545_abnormal_hematopoietic_system1.48725231
44MP0005397_hematopoietic_system_phenotyp1.48725231
45MP0001790_abnormal_immune_system1.48566976
46MP0005387_immune_system_phenotype1.48566976
47MP0005365_abnormal_bile_salt1.47990514
48MP0005000_abnormal_immune_tolerance1.47188213
49MP0002106_abnormal_muscle_physiology1.46638384
50MP0001853_heart_inflammation1.45500477
51MP0001873_stomach_inflammation1.45481744
52MP0003195_calcinosis1.45428129
53MP0002419_abnormal_innate_immunity1.44530136
54MP0009840_abnormal_foam_cell1.44450858
55MP0004782_abnormal_surfactant_physiolog1.43728667
56MP0005620_abnormal_muscle_contractility1.43280213
57MP0002822_catalepsy1.42557003
58MP0002876_abnormal_thyroid_physiology1.42354658
59MP0002269_muscular_atrophy1.40322660
60MP0001929_abnormal_gametogenesis1.40077300
61MP0006082_CNS_inflammation1.39403221
62MP0003724_increased_susceptibility_to1.37642004
63MP0005319_abnormal_enzyme/_coenzyme1.32479782
64MP0003879_abnormal_hair_cell1.30815094
65MP0006035_abnormal_mitochondrial_morpho1.28994834
66MP0009643_abnormal_urine_homeostasis1.28965867
67MP0006138_congestive_heart_failure1.28651909
68MP0005451_abnormal_body_composition1.28308641
69MP0009333_abnormal_splenocyte_physiolog1.27825129
70MP0008875_abnormal_xenobiotic_pharmacok1.24562980
71MP0008260_abnormal_autophagy1.22991118
72MP0003183_abnormal_peptide_metabolism1.21981515
73MP0004484_altered_response_of1.19071972
74MP0000716_abnormal_immune_system1.18440432
75MP0005167_abnormal_blood-brain_barrier1.17530440
76MP0002398_abnormal_bone_marrow1.17208380
77MP0005332_abnormal_amino_acid1.16923509
78MP0008469_abnormal_protein_level1.16749311
79MP0005310_abnormal_salivary_gland1.16161790
80MP0001764_abnormal_homeostasis1.16048315
81MP0010630_abnormal_cardiac_muscle1.15874195
82MP0001348_abnormal_lacrimal_gland1.14941951
83MP0003075_altered_response_to1.13397435
84MP0008004_abnormal_stomach_pH1.12018258
85MP0004043_abnormal_pH_regulation1.11897596
86MP0002405_respiratory_system_inflammati1.11076479
87MP0001533_abnormal_skeleton_physiology1.09002127
88MP0005166_decreased_susceptibility_to1.08002495
89MP0000013_abnormal_adipose_tissue1.07039165
90MP0003763_abnormal_thymus_physiology1.06918599
91MP0005369_muscle_phenotype1.05845033
92MP0005375_adipose_tissue_phenotype1.05336494
93MP0010329_abnormal_lipoprotein_level1.03560989
94MP0003011_delayed_dark_adaptation1.02783448
95MP0001845_abnormal_inflammatory_respons1.02703302
96MP0004947_skin_inflammation1.02576840
97MP0003300_gastrointestinal_ulcer1.01379133
98MP0005535_abnormal_body_temperature1.01374413
99MP0002118_abnormal_lipid_homeostasis1.00606877
100MP0009764_decreased_sensitivity_to0.99739546
101MP0002138_abnormal_hepatobiliary_system0.99614052
102MP0002166_altered_tumor_susceptibility0.99355724
103MP0001756_abnormal_urination0.97894647
104MP0002723_abnormal_immune_serum0.97603633
105MP0002429_abnormal_blood_cell0.97331645
106MP0002722_abnormal_immune_system0.97170206
107MP0003137_abnormal_impulse_conducting0.97134143
108MP0003221_abnormal_cardiomyocyte_apopto0.96767524
109MP0000689_abnormal_spleen_morphology0.96383814
110MP0001666_abnormal_nutrient_absorption0.95477414
111MP0005085_abnormal_gallbladder_physiolo0.95050502
112MP0002332_abnormal_exercise_endurance0.94847936
113MP0005266_abnormal_metabolism0.94593921
114MP0002078_abnormal_glucose_homeostasis0.94220754
115MP0000681_abnormal_thyroid_gland0.93461685
116MP0005584_abnormal_enzyme/coenzyme_acti0.93380675
117MP0002452_abnormal_antigen_presenting0.92602326
118MP0000249_abnormal_blood_vessel0.92372239
119MP0003866_abnormal_defecation0.92143303
120MP0005636_abnormal_mineral_homeostasis0.90511587
121MP0000759_abnormal_skeletal_muscle0.90012532
122MP0005666_abnormal_adipose_tissue0.89343189
123MP0001819_abnormal_immune_cell0.87770730
124MP0002877_abnormal_melanocyte_morpholog0.87578938
125MP0000465_gastrointestinal_hemorrhage0.87146707
126MP0002161_abnormal_fertility/fecundity0.86940008
127MP0004145_abnormal_muscle_electrophysio0.86722851
128MP0008874_decreased_physiological_sensi0.86612011
129MP0001800_abnormal_humoral_immune0.85921566
130MP0005360_urolithiasis0.85771897
131MP0002420_abnormal_adaptive_immunity0.85698171
132MP0000609_abnormal_liver_physiology0.85564205
133MP0002933_joint_inflammation0.82980417
134MP0002998_abnormal_bone_remodeling0.81541609
135MP0000230_abnormal_systemic_arterial0.79334113
136MP0001765_abnormal_ion_homeostasis0.78830871
137MP0002653_abnormal_ependyma_morphology0.77871218
138MP0010155_abnormal_intestine_physiology0.77107305
139MP0009115_abnormal_fat_cell0.76812551
140MP0003656_abnormal_erythrocyte_physiolo0.76650835
141MP0000604_amyloidosis0.76176861
142MP0005083_abnormal_biliary_tract0.75903666
143MP0005165_increased_susceptibility_to0.75593818
144MP0005075_abnormal_melanosome_morpholog0.71457278
145MP0001663_abnormal_digestive_system0.70111622
146MP0002127_abnormal_cardiovascular_syste0.64051253

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.61103154
2Hepatic necrosis (HP:0002605)4.49733169
3Abnormal mitochondria in muscle tissue (HP:0008316)4.43932457
4Severe visual impairment (HP:0001141)4.37876046
5Mitochondrial inheritance (HP:0001427)4.14549881
6Acute encephalopathy (HP:0006846)4.14255872
7Hepatocellular necrosis (HP:0001404)4.08004970
8Ventricular tachycardia (HP:0004756)3.87041216
9Increased CSF lactate (HP:0002490)3.79464154
10Progressive macrocephaly (HP:0004481)3.77935213
11Abnormality of macrophages (HP:0004311)3.71358353
12Sudden death (HP:0001699)3.70489894
13Prolonged bleeding time (HP:0003010)3.58904566
14Chronic obstructive pulmonary disease (HP:0006510)3.53889412
15Obstructive lung disease (HP:0006536)3.53889412
16Dicarboxylic aciduria (HP:0003215)3.50401072
17Abnormality of dicarboxylic acid metabolism (HP:0010995)3.50401072
18Exercise-induced muscle cramps (HP:0003710)3.47605845
19Myoglobinuria (HP:0002913)3.47256060
20Calf muscle hypertrophy (HP:0008981)3.39511299
21Cerebral edema (HP:0002181)3.32991917
22Purpura (HP:0000979)3.32051705
23Exercise-induced myalgia (HP:0003738)3.23667666
24Petechiae (HP:0000967)3.21996693
25Absent/shortened dynein arms (HP:0200106)3.20583435
26Dynein arm defect of respiratory motile cilia (HP:0012255)3.20583435
27Generalized aminoaciduria (HP:0002909)3.19784742
28Increased muscle lipid content (HP:0009058)3.18673558
29Abnormality of fatty-acid metabolism (HP:0004359)3.17218898
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.16562469
31Lipoatrophy (HP:0100578)3.11443686
32Palpitations (HP:0001962)3.08323167
33Abnormality of the nasal mucosa (HP:0000433)3.08083090
34Rhabdomyolysis (HP:0003201)3.07279681
35Elevated erythrocyte sedimentation rate (HP:0003565)3.06611024
36Myositis (HP:0100614)3.02311821
37Exercise intolerance (HP:0003546)3.02055040
38Lactic acidosis (HP:0003128)3.00665678
39Lipid accumulation in hepatocytes (HP:0006561)2.97293771
40Muscle fiber splitting (HP:0003555)2.95185133
41Muscle hypertrophy of the lower extremities (HP:0008968)2.93165931
42Hypoglycemic coma (HP:0001325)2.91416568
43Respiratory failure (HP:0002878)2.90119492
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78812118
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78812118
46Increased intramyocellular lipid droplets (HP:0012240)2.74221231
47Asymmetric septal hypertrophy (HP:0001670)2.72950626
48Epistaxis (HP:0000421)2.72801326
49Male infertility (HP:0003251)2.72755484
50Right ventricular cardiomyopathy (HP:0011663)2.72346117
51Neoplasm of head and neck (HP:0012288)2.71778141
52Esophageal neoplasm (HP:0100751)2.71778141
53Dilated cardiomyopathy (HP:0001644)2.70583410
54Gingivitis (HP:0000230)2.69288340
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.64837484
56Tubulointerstitial nephritis (HP:0001970)2.61007252
57Nausea (HP:0002018)2.58298697
58Increased serum lactate (HP:0002151)2.57348551
59Increased hepatocellular lipid droplets (HP:0006565)2.56231280
60Dysostosis multiplex (HP:0000943)2.54709729
61Congenital malformation of the right heart (HP:0011723)2.53270288
62Double outlet right ventricle (HP:0001719)2.53270288
63Glycosuria (HP:0003076)2.52856177
64Abnormality of urine glucose concentration (HP:0011016)2.52856177
65Meningitis (HP:0001287)2.52674628
66Subaortic stenosis (HP:0001682)2.52224824
67Abnormality of the left ventricular outflow tract (HP:0011103)2.52224824
68Menstrual irregularities (HP:0000858)2.50414639
69Infertility (HP:0000789)2.50058197
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49862939
71Lethargy (HP:0001254)2.49852467
72Abnormality of liposaccharide metabolism (HP:0010968)2.49519576
73Abnormality of glycosphingolipid metabolism (HP:0004343)2.49519576
74Abnormality of glycolipid metabolism (HP:0010969)2.49519576
75Atrial fibrillation (HP:0005110)2.49160621
76Increased IgE level (HP:0003212)2.48474976
77Colitis (HP:0002583)2.47454677
78Ketoacidosis (HP:0001993)2.45744549
79Gastrointestinal inflammation (HP:0004386)2.45670000
80Gastrointestinal infarctions (HP:0005244)2.45330394
81Prolonged neonatal jaundice (HP:0006579)2.42734823
82Abnormal rod and cone electroretinograms (HP:0008323)2.42596749
83Orchitis (HP:0100796)2.38203137
84Inflammation of the large intestine (HP:0002037)2.36441050
85Hypertriglyceridemia (HP:0002155)2.33799095
86Loss of speech (HP:0002371)2.31957092
87Gingival bleeding (HP:0000225)2.30255766
88Cellulitis (HP:0100658)2.29714237
89Renal Fanconi syndrome (HP:0001994)2.28564982
90Attenuation of retinal blood vessels (HP:0007843)2.26385077
91Recurrent abscess formation (HP:0002722)2.25630814
92Primary atrial arrhythmia (HP:0001692)2.25524253
93Abnormality of the calf musculature (HP:0001430)2.25154324
94Conjunctival hamartoma (HP:0100780)2.23863873
95Tinnitus (HP:0000360)2.23681733
96Hyperglycinuria (HP:0003108)2.22846337
97Ketosis (HP:0001946)2.22066312
98Mediastinal lymphadenopathy (HP:0100721)2.22005550
99Abnormal ciliary motility (HP:0012262)2.21157940
100Bundle branch block (HP:0011710)2.20955586
101Progressive neurologic deterioration (HP:0002344)2.20876546
102Recurrent pneumonia (HP:0006532)2.19729468
103Resting tremor (HP:0002322)2.19668210
104Exertional dyspnea (HP:0002875)2.19555962
105Supraventricular tachycardia (HP:0004755)2.19244362
106Abnormality of lateral ventricle (HP:0030047)2.18631435
107Recurrent fungal infections (HP:0002841)2.18007326
1083-Methylglutaconic aciduria (HP:0003535)2.17620365
109Vasculitis (HP:0002633)2.16936030
110Amyloidosis (HP:0011034)2.16673057
111Abnormal respiratory epithelium morphology (HP:0012253)2.16498848
112Abnormal respiratory motile cilium morphology (HP:0005938)2.16498848
113Optic neuritis (HP:0100653)2.16472217
114Retrobulbar optic neuritis (HP:0100654)2.16472217
115Systemic lupus erythematosus (HP:0002725)2.15740136
116Optic disc pallor (HP:0000543)2.15227050
117Syncope (HP:0001279)2.13961672
118Prolonged QT interval (HP:0001657)2.12135641
119Hypertensive crisis (HP:0100735)2.10935160
120Supraventricular arrhythmia (HP:0005115)2.10788553
121Chest pain (HP:0100749)2.10586322
122Bulbar palsy (HP:0001283)2.10516793
123Ventricular arrhythmia (HP:0004308)2.10075041
124CNS demyelination (HP:0007305)2.09726013
125Neuroendocrine neoplasm (HP:0100634)2.09604300
126Recurrent bacterial skin infections (HP:0005406)2.07801526
127Methylmalonic aciduria (HP:0012120)2.07296072
128Hyperkalemia (HP:0002153)2.06700318
129Bony spicule pigmentary retinopathy (HP:0007737)2.06193280
130Vacuolated lymphocytes (HP:0001922)2.05421559
131Eczematoid dermatitis (HP:0000976)2.04719243
132Recurrent gram-negative bacterial infections (HP:0005420)2.04661811
133Abnormality of the costochondral junction (HP:0000919)2.04580966
134Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04542493
135Abnormality of polysaccharide metabolism (HP:0011012)2.04542493
136Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04542493
137Menorrhagia (HP:0000132)2.04106162
138Hyperthyroidism (HP:0000836)2.03976826
139Testicular atrophy (HP:0000029)2.03817948
140Stomatitis (HP:0010280)2.03155987
141Axonal loss (HP:0003447)2.02937590
142Nasal polyposis (HP:0100582)2.01607018
143Distal lower limb muscle weakness (HP:0009053)2.01213274
144EMG: myopathic abnormalities (HP:0003458)2.00904103
145Ventricular fibrillation (HP:0001663)2.00888466
146Muscle fibrillation (HP:0010546)1.98995551
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98777403
148Vomiting (HP:0002013)1.98677274
149Proximal tubulopathy (HP:0000114)1.97507232
150Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97482239
151Recurrent skin infections (HP:0001581)1.97141415
152Oligomenorrhea (HP:0000876)1.96816504
153Microvesicular hepatic steatosis (HP:0001414)1.96378719
154Abnormality of dental color (HP:0011073)1.95580263
155Ragged-red muscle fibers (HP:0003200)1.95416347
156Hyporeflexia of lower limbs (HP:0002600)1.94569057
157Abnormal respiratory motile cilium physiology (HP:0012261)1.93698595
158Increased IgM level (HP:0003496)1.93628343
159Growth hormone excess (HP:0000845)1.92892688
160Spontaneous hematomas (HP:0007420)1.92618035
161Hypoplasia of the thymus (HP:0000778)1.91958219
162Increased serum ferritin (HP:0003281)1.91888014
163Easy fatigability (HP:0003388)1.90405759
164Heart block (HP:0012722)1.89855616
165Abnormality of alanine metabolism (HP:0010916)1.89031186
166Hyperalaninemia (HP:0003348)1.89031186
167Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89031186
168Metabolic acidosis (HP:0001942)1.88193454
169Seborrheic dermatitis (HP:0001051)1.87936701
170Respiratory difficulties (HP:0002880)1.87934419
171Cone-rod dystrophy (HP:0000548)1.87381372
172Gastrointestinal stroma tumor (HP:0100723)1.87325089
173Gout (HP:0001997)1.85747780
174Amelogenesis imperfecta (HP:0000705)1.85695833
175Renal cortical cysts (HP:0000803)1.84493352
176Urticaria (HP:0001025)1.84406644
177Hypergammaglobulinemia (HP:0010702)1.84040309
178Cerebral palsy (HP:0100021)1.83048541
179Hyperammonemia (HP:0001987)1.82734976
180Pheochromocytoma (HP:0002666)1.81659502
181Hypoalphalipoproteinemia (HP:0003233)1.79799946
182Encephalitis (HP:0002383)1.79738356
183Insulin-resistant diabetes mellitus (HP:0000831)1.79652068
184Hepatosplenomegaly (HP:0001433)1.79406363
185Urinary glycosaminoglycan excretion (HP:0003541)1.78775977
186Mucopolysacchariduria (HP:0008155)1.78775977
187Increased cerebral lipofuscin (HP:0011813)1.78110400
188Hypochromic anemia (HP:0001931)1.76933495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK43.99363205
2PDK33.99363205
3MYLK3.50467094
4PDK23.07259332
5PLK42.84046177
6NME22.77012219
7TESK22.69660662
8TBK12.67917074
9TNK22.66807259
10ERN12.55311364
11BCKDK2.50888093
12TTN2.49347378
13ARAF2.34884850
14PIM22.31880643
15LMTK22.20918493
16TESK12.18722884
17DDR22.16555772
18OBSCN2.14634333
19MAP3K142.06437499
20STK381.64868495
21WNK41.60955600
22IRAK31.59861996
23PINK11.58521414
24TYK21.56804449
25NEK11.54371852
26MAP3K121.53362426
27NEK91.42813061
28IKBKE1.42771417
29CSF1R1.41287374
30DYRK1B1.37991621
31MAP3K111.37174697
32IKBKB1.36915146
33PDK11.36428189
34GRK61.35235069
35EIF2AK11.34359327
36MAP4K21.34232385
37NME11.34153101
38BRAF1.33867404
39FES1.33667300
40MAP4K11.33178118
41MAP2K31.28086700
42PRKD21.27823369
43SIK21.27363524
44MUSK1.27075325
45IRAK41.20207023
46STK241.18045226
47CDK191.16565638
48PRPF4B1.16533452
49MAP3K11.14691913
50CAMK1G1.11952400
51MARK21.11339486
52BRSK21.11188383
53TXK1.10431058
54ILK1.09719247
55ZAP701.07045857
56CSK1.04093237
57BRD41.03997610
58MAP2K20.97523311
59TAOK20.95365389
60SIK10.95155988
61MAP3K30.94618742
62PIK3CA0.94357529
63CAMKK20.92391041
64MATK0.90902741
65CAMK1D0.89692344
66AKT30.88772144
67PIK3CG0.88429700
68TEC0.88283594
69NEK20.88076045
70HCK0.86722196
71PRKD30.86375933
72STK38L0.83820816
73EIF2AK30.82222745
74ABL20.80910826
75FGFR40.79084573
76PHKG10.78806509
77PHKG20.78806509
78SYK0.78090785
79MAP3K130.77508692
80INSRR0.77302368
81JAK10.77192242
82LYN0.76846605
83JAK30.75414568
84MARK30.74276274
85DAPK30.73520607
86TAOK30.71701190
87ZAK0.70873785
88KDR0.69917927
89RPS6KA20.69878011
90FLT30.69267680
91MAPKAPK30.68148755
92BMPR20.68054304
93TIE10.67599939
94EIF2AK20.67376706
95MAP3K70.64377673
96CHUK0.64146121
97PRKG20.64090789
98MST1R0.62947589
99KSR20.62362695
100FER0.62332238
101EPHB10.62216077
102RIPK40.62164119
103TRIB30.61951960
104CDC42BPA0.60675884
105MAP2K60.59879974
106PTK2B0.59793115
107BTK0.59733772
108STK40.58927081
109MAP3K50.58428710
110BUB10.58322489
111LCK0.58246793
112BRSK10.58159837
113GRK70.58094262
114TRPM70.56524125
115FGR0.55098162
116PIM10.54620082
117HIPK20.53108578
118RPS6KA40.50815878
119PRKCD0.50402204
120MAPK120.48263098
121TLK10.48056876
122PTK60.46157129
123ADRBK20.45915916
124KIT0.45545717
125CAMK10.44759050
126TYRO30.44379039
127RPS6KA60.44239777
128TAOK10.43597526
129TGFBR20.43361177
130PKN20.43184096
131JAK20.43019260
132PRKD10.42879424
133MAPK110.42128382
134RPS6KA10.42115946
135PDPK10.42000343
136BMX0.41313377
137ITK0.41192450
138DMPK0.41096606
139STK160.40964266
140VRK10.40918658
141DAPK20.40824906
142PLK20.40384184
143IRAK20.39656254
144NLK0.39224516
145RPS6KL10.39186829
146RPS6KC10.39186829
147BLK0.38369629
148MAPK150.38176930
149RIPK10.37706334
150SIK30.37173147
151MAPK70.37003686
152CAMK2D0.36585647

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.35181517
2Oxidative phosphorylation_Homo sapiens_hsa001904.32701420
3Parkinsons disease_Homo sapiens_hsa050123.81062588
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81114851
5Alzheimers disease_Homo sapiens_hsa050102.70905337
6Fatty acid biosynthesis_Homo sapiens_hsa000612.64387747
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.63260332
8Huntingtons disease_Homo sapiens_hsa050162.57915326
9Cardiac muscle contraction_Homo sapiens_hsa042602.48561658
10Propanoate metabolism_Homo sapiens_hsa006402.45403755
11Proteasome_Homo sapiens_hsa030502.25376932
12Fatty acid degradation_Homo sapiens_hsa000712.15627821
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15441398
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.10504305
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09588980
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08819542
17Carbon metabolism_Homo sapiens_hsa012002.06646905
18Pyruvate metabolism_Homo sapiens_hsa006201.89034127
19Sulfur metabolism_Homo sapiens_hsa009201.83639848
20Osteoclast differentiation_Homo sapiens_hsa043801.79693465
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76975282
22B cell receptor signaling pathway_Homo sapiens_hsa046621.70565059
23Protein export_Homo sapiens_hsa030601.65854041
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.53359105
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50230484
26Fatty acid metabolism_Homo sapiens_hsa012121.50083324
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47577028
28Acute myeloid leukemia_Homo sapiens_hsa052211.45987609
29Peroxisome_Homo sapiens_hsa041461.41102330
30Ribosome_Homo sapiens_hsa030101.39617284
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32875220
32Hematopoietic cell lineage_Homo sapiens_hsa046401.32841714
33Pentose phosphate pathway_Homo sapiens_hsa000301.29236352
34Fatty acid elongation_Homo sapiens_hsa000621.29170571
35Fructose and mannose metabolism_Homo sapiens_hsa000511.27623751
36Butanoate metabolism_Homo sapiens_hsa006501.25041723
37Collecting duct acid secretion_Homo sapiens_hsa049661.23750943
38Toxoplasmosis_Homo sapiens_hsa051451.20451554
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16961257
40Legionellosis_Homo sapiens_hsa051341.14363110
41beta-Alanine metabolism_Homo sapiens_hsa004101.10475720
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08946931
43Vitamin B6 metabolism_Homo sapiens_hsa007501.08583638
44Herpes simplex infection_Homo sapiens_hsa051681.06571572
45Biosynthesis of amino acids_Homo sapiens_hsa012301.06227924
46Tryptophan metabolism_Homo sapiens_hsa003801.05725172
47Platelet activation_Homo sapiens_hsa046111.03570576
48Galactose metabolism_Homo sapiens_hsa000521.01292927
49Phenylalanine metabolism_Homo sapiens_hsa003601.01250102
50PPAR signaling pathway_Homo sapiens_hsa033201.01063346
51Endocytosis_Homo sapiens_hsa041441.00472740
52Starch and sucrose metabolism_Homo sapiens_hsa005000.98466300
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.98128817
54Malaria_Homo sapiens_hsa051440.97969780
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97909421
56Other glycan degradation_Homo sapiens_hsa005110.96767870
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.95650350
58Rheumatoid arthritis_Homo sapiens_hsa053230.95553771
59Folate biosynthesis_Homo sapiens_hsa007900.95547066
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94790122
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93827719
62Chemokine signaling pathway_Homo sapiens_hsa040620.92143526
63Sulfur relay system_Homo sapiens_hsa041220.91232982
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89353105
65Graft-versus-host disease_Homo sapiens_hsa053320.85995849
66Olfactory transduction_Homo sapiens_hsa047400.85759501
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83679449
68Renin-angiotensin system_Homo sapiens_hsa046140.82271170
69Metabolic pathways_Homo sapiens_hsa011000.79590686
70Allograft rejection_Homo sapiens_hsa053300.79404535
71VEGF signaling pathway_Homo sapiens_hsa043700.78481403
72Type I diabetes mellitus_Homo sapiens_hsa049400.77137276
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.75260540
74Staphylococcus aureus infection_Homo sapiens_hsa051500.74904502
75Lysosome_Homo sapiens_hsa041420.74794515
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71877850
77Dilated cardiomyopathy_Homo sapiens_hsa054140.70764905
78Vibrio cholerae infection_Homo sapiens_hsa051100.70561445
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70181159
80RNA polymerase_Homo sapiens_hsa030200.69962979
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69115980
82Viral myocarditis_Homo sapiens_hsa054160.68473005
83Pyrimidine metabolism_Homo sapiens_hsa002400.67968324
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67857150
85T cell receptor signaling pathway_Homo sapiens_hsa046600.66112867
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66073262
87Glutathione metabolism_Homo sapiens_hsa004800.65025487
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.63202765
89African trypanosomiasis_Homo sapiens_hsa051430.63098852
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.62136206
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.61885161
92Regulation of autophagy_Homo sapiens_hsa041400.61805454
93Leishmaniasis_Homo sapiens_hsa051400.60940261
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60547971
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60486897
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59544325
97TNF signaling pathway_Homo sapiens_hsa046680.58592025
98Notch signaling pathway_Homo sapiens_hsa043300.57677826
99Arginine and proline metabolism_Homo sapiens_hsa003300.57145846
100Pertussis_Homo sapiens_hsa051330.56988975
101Type II diabetes mellitus_Homo sapiens_hsa049300.56452219
102ABC transporters_Homo sapiens_hsa020100.55864060
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55476986
104Salmonella infection_Homo sapiens_hsa051320.54077392
105Histidine metabolism_Homo sapiens_hsa003400.52341238
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.52300937
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.51863889
108Selenocompound metabolism_Homo sapiens_hsa004500.50899718
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49072409
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48592944
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47974377
112Phagosome_Homo sapiens_hsa041450.47850022
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.47726911
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47597066
115Arachidonic acid metabolism_Homo sapiens_hsa005900.47495802
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47490139
117Tuberculosis_Homo sapiens_hsa051520.46578315
118Shigellosis_Homo sapiens_hsa051310.45480090
119Antigen processing and presentation_Homo sapiens_hsa046120.44478038
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42702028
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42315408
122Autoimmune thyroid disease_Homo sapiens_hsa053200.41912559
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41731729
124Influenza A_Homo sapiens_hsa051640.41531422
125Synaptic vesicle cycle_Homo sapiens_hsa047210.41473951
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41118953
127Purine metabolism_Homo sapiens_hsa002300.40965455
128Insulin signaling pathway_Homo sapiens_hsa049100.39389858
129Hepatitis C_Homo sapiens_hsa051600.38958554
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38071976
131Inositol phosphate metabolism_Homo sapiens_hsa005620.37146584
132Insulin resistance_Homo sapiens_hsa049310.37041595
133Primary immunodeficiency_Homo sapiens_hsa053400.36769631
134Glycerolipid metabolism_Homo sapiens_hsa005610.36712024
135Measles_Homo sapiens_hsa051620.36135135
136Asthma_Homo sapiens_hsa053100.36115672
137Fat digestion and absorption_Homo sapiens_hsa049750.35907815
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35845593
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35795755
140Chemical carcinogenesis_Homo sapiens_hsa052040.33336115
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32813473
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32760173
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.31195938
144Salivary secretion_Homo sapiens_hsa049700.30952546
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.30375712
146Tyrosine metabolism_Homo sapiens_hsa003500.30317891
147Hepatitis B_Homo sapiens_hsa051610.30275687
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29992690
149Complement and coagulation cascades_Homo sapiens_hsa046100.29803354
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29504790
151Epstein-Barr virus infection_Homo sapiens_hsa051690.28345091

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