DNAJC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18560900
2synaptic vesicle maturation (GO:0016188)5.92290887
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.47580983
4locomotory exploration behavior (GO:0035641)5.43420031
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.35427810
6* synaptic vesicle exocytosis (GO:0016079)5.25967397
7vocalization behavior (GO:0071625)5.25223022
8regulation of synaptic vesicle exocytosis (GO:2000300)5.01909560
9glutamate secretion (GO:0014047)4.97878571
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94410879
11layer formation in cerebral cortex (GO:0021819)4.78299863
12protein localization to synapse (GO:0035418)4.77181512
13regulation of glutamate receptor signaling pathway (GO:1900449)4.70260227
14protein localization to endosome (GO:0036010)4.60435518
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.56503109
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.43426300
17regulation of synaptic vesicle transport (GO:1902803)4.41976925
18exploration behavior (GO:0035640)4.41544372
19* neurotransmitter secretion (GO:0007269)4.39092073
20neuron cell-cell adhesion (GO:0007158)4.38369410
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23620627
22regulation of synapse structural plasticity (GO:0051823)4.22182914
23regulation of neuronal synaptic plasticity (GO:0048168)4.10307019
24proline transport (GO:0015824)4.05328662
25cytoskeletal anchoring at plasma membrane (GO:0007016)4.01464586
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97785727
27glutamate receptor signaling pathway (GO:0007215)3.91513439
28dendritic spine morphogenesis (GO:0060997)3.90874762
29cellular potassium ion homeostasis (GO:0030007)3.89374804
30gamma-aminobutyric acid transport (GO:0015812)3.88294424
31synaptic transmission, glutamatergic (GO:0035249)3.85863340
32neuronal action potential propagation (GO:0019227)3.82678902
33positive regulation of synapse maturation (GO:0090129)3.81756684
34sodium ion export (GO:0071436)3.79324160
35neuron-neuron synaptic transmission (GO:0007270)3.75146759
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71027002
37activation of protein kinase A activity (GO:0034199)3.70630179
38long-term memory (GO:0007616)3.66470425
39neurotransmitter-gated ion channel clustering (GO:0072578)3.65665525
40neuron recognition (GO:0008038)3.63532912
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60719694
42positive regulation of membrane potential (GO:0045838)3.55300363
43* neurotransmitter transport (GO:0006836)3.55242594
44regulation of early endosome to late endosome transport (GO:2000641)3.53139404
45dendrite morphogenesis (GO:0048813)3.47384945
46negative regulation of erythrocyte differentiation (GO:0045647)3.47261295
47regulation of postsynaptic membrane potential (GO:0060078)3.47156026
48synaptic vesicle endocytosis (GO:0048488)3.46474242
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45854204
50prepulse inhibition (GO:0060134)3.44688915
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.39324568
52regulation of vesicle fusion (GO:0031338)3.38693166
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36059902
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.33280163
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.32160400
56regulation of dendritic spine morphogenesis (GO:0061001)3.31557262
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30569156
58transmission of nerve impulse (GO:0019226)3.30125712
59regulation of neurotransmitter secretion (GO:0046928)3.29490286
60neuromuscular process controlling balance (GO:0050885)3.28639052
61axonal fasciculation (GO:0007413)3.27325362
62cerebellar Purkinje cell differentiation (GO:0021702)3.26430349
63mating behavior (GO:0007617)3.24628068
64regulation of synaptic plasticity (GO:0048167)3.22879008
65* regulation of neurotransmitter levels (GO:0001505)3.21694000
66cell communication by electrical coupling (GO:0010644)3.19694691
67vesicle transport along microtubule (GO:0047496)3.17066178
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16165244
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14942400
70barbed-end actin filament capping (GO:0051016)3.14730294
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.14647811
72long-term synaptic potentiation (GO:0060291)3.14006009
73response to histamine (GO:0034776)3.12555941
74synapse assembly (GO:0007416)3.12538709
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.11533360
76regulation of ARF protein signal transduction (GO:0032012)3.11306413
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08129666
78membrane hyperpolarization (GO:0060081)3.07687025
79innervation (GO:0060384)3.07554456
80postsynaptic membrane organization (GO:0001941)3.05445039
81regulation of neurotransmitter transport (GO:0051588)3.04724563
82positive regulation of neurotransmitter transport (GO:0051590)3.03136595
83auditory behavior (GO:0031223)3.02382222
84glycine transport (GO:0015816)3.01679583
85membrane depolarization (GO:0051899)2.99344943
86response to auditory stimulus (GO:0010996)2.96117343
87cell migration in hindbrain (GO:0021535)2.94465694
88social behavior (GO:0035176)2.93799068
89intraspecies interaction between organisms (GO:0051703)2.93799068
90mannose metabolic process (GO:0006013)2.93783764
91neuromuscular process controlling posture (GO:0050884)2.93711897
92signal complex assembly (GO:0007172)2.93518737
93positive regulation of neurotransmitter secretion (GO:0001956)2.93394400
94organelle transport along microtubule (GO:0072384)2.93113815
95membrane depolarization during action potential (GO:0086010)2.92638845
96cerebellar Purkinje cell layer development (GO:0021680)2.92352577
97clathrin coat assembly (GO:0048268)2.90913705
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90303057
99cerebellar granule cell differentiation (GO:0021707)2.90164351
100regulation of synapse maturation (GO:0090128)2.89803970
101synapse organization (GO:0050808)2.87730537
102axon cargo transport (GO:0008088)2.87630410
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87483839
104behavioral fear response (GO:0001662)2.87370218
105behavioral defense response (GO:0002209)2.87370218
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87011678
107dopamine receptor signaling pathway (GO:0007212)2.86246030
108learning (GO:0007612)2.85337367
109activation of Rac GTPase activity (GO:0032863)2.84544511
110regulation of ARF GTPase activity (GO:0032312)2.84333570
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.83794371
112protein retention in ER lumen (GO:0006621)2.80015033
113positive regulation of Cdc42 GTPase activity (GO:0043089)2.73259938
114amino acid import (GO:0043090)2.73014766
115epithelial cell differentiation involved in prostate gland development (GO:0060742)2.71695419
116cell-cell junction maintenance (GO:0045217)2.71563089
117response to peptidoglycan (GO:0032494)2.70544263
118regulation of regulated secretory pathway (GO:1903305)2.67351889
119stress fiber assembly (GO:0043149)2.66121481
120adherens junction assembly (GO:0034333)2.64342126
121COPI coating of Golgi vesicle (GO:0048205)2.63391715
122Golgi transport vesicle coating (GO:0048200)2.63391715
123regulation of leukocyte degranulation (GO:0043300)2.62720584
124L-amino acid import (GO:0043092)2.61458991
125negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61456582
126positive regulation of receptor recycling (GO:0001921)2.60390840
127maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59607262
128positive regulation of cellular amide metabolic process (GO:0034250)2.59030989
129positive regulation of protein dephosphorylation (GO:0035307)2.58871698
130cell-substrate adherens junction assembly (GO:0007045)2.56996282
131focal adhesion assembly (GO:0048041)2.56996282
132peptidyl-tyrosine autophosphorylation (GO:0038083)2.54637425
133cell-substrate junction assembly (GO:0007044)2.53208657
134positive regulation by symbiont of host defense response (GO:0052509)2.52511092
135modulation by symbiont of host defense response (GO:0052031)2.52511092
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52511092
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52511092
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.52511092
139modulation by symbiont of host immune response (GO:0052553)2.52511092
140modulation by symbiont of host cellular process (GO:0044068)2.50863443
141semaphorin-plexin signaling pathway (GO:0071526)2.50709254
142cortical actin cytoskeleton organization (GO:0030866)2.49609986
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.49319771
144macrophage activation involved in immune response (GO:0002281)2.47980899
145negative regulation of cell killing (GO:0031342)2.47403760
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.47403760
147regulation of defense response to virus by virus (GO:0050690)2.46638037
148hemidesmosome assembly (GO:0031581)2.39931827
149response to laminar fluid shear stress (GO:0034616)2.38214890
150response to muramyl dipeptide (GO:0032495)2.37764372
151positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.34726360
152regulation of myeloid leukocyte mediated immunity (GO:0002886)2.34282236
153positive regulation of Rap GTPase activity (GO:0032854)2.34193348
154negative regulation of fatty acid transport (GO:2000192)2.34173640
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33140941
156regulation of T-helper 2 cell differentiation (GO:0045628)2.32626160
157regulation of NFAT protein import into nucleus (GO:0051532)2.30032507
158hypotonic response (GO:0006971)2.29006280
159positive regulation of regulated secretory pathway (GO:1903307)2.28435701
160glucose 6-phosphate metabolic process (GO:0051156)2.27647667
161negative regulation of toll-like receptor signaling pathway (GO:0034122)2.26629280
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.24172270
163detection of other organism (GO:0098543)2.24057779
164regulation of extracellular matrix disassembly (GO:0010715)2.23117161
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.21168923
166modulation by virus of host process (GO:0019054)2.20392653
167regulation of cellular amide metabolic process (GO:0034248)2.19273988
168cortical cytoskeleton organization (GO:0030865)2.19171652
169positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.18428651
170regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.18428651
171adenosine receptor signaling pathway (GO:0001973)2.17706677
172modulation by virus of host morphology or physiology (GO:0019048)2.17170755
173actin filament bundle organization (GO:0061572)2.16636026
174actin filament bundle assembly (GO:0051017)2.16636026
175regulation of amyloid precursor protein catabolic process (GO:1902991)2.16088566
176potassium ion homeostasis (GO:0055075)2.15384846
177receptor recycling (GO:0001881)2.15353271
178protein targeting to plasma membrane (GO:0072661)2.14956505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76443749
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.50185245
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.18282994
4GBX2_23144817_ChIP-Seq_PC3_Human3.18106260
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08374018
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07804579
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01854031
8LXR_22292898_ChIP-Seq_THP-1_Human2.81308268
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69956508
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69956508
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69463533
12REST_21632747_ChIP-Seq_MESCs_Mouse2.69102702
13DROSHA_22980978_ChIP-Seq_HELA_Human2.61680370
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.59799187
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58326166
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55471131
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52819342
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51705842
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48101614
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44575165
21VDR_21846776_ChIP-Seq_THP-1_Human2.44526242
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.38977634
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.31914144
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.31163398
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.26284682
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24556936
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.24403715
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21471471
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20957244
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.20330192
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.19734141
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.13907812
33TCF7_22412390_ChIP-Seq_EML_Mouse2.13576265
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.12363886
35KDM2B_26808549_Chip-Seq_DND41_Human2.12222046
36* RACK7_27058665_Chip-Seq_MCF-7_Human2.11511342
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10049299
38AR_21572438_ChIP-Seq_LNCaP_Human2.04181406
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02185749
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98314795
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94729589
42MYC_22102868_ChIP-Seq_BL_Human1.91890927
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88677294
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83569317
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77465365
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67722590
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62274759
48VDR_24763502_ChIP-Seq_THP-1_Human1.60453271
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.59355625
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57345066
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56980931
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56173539
53SMAD4_21799915_ChIP-Seq_A2780_Human1.56000460
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52428672
55ZNF274_21170338_ChIP-Seq_K562_Hela1.50674991
56TAF15_26573619_Chip-Seq_HEK293_Human1.50650057
57SMC4_20622854_ChIP-Seq_HELA_Human1.50093512
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50021903
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49936739
60CLOCK_20551151_ChIP-Seq_293T_Human1.46410422
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.46221957
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45831240
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45543769
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44890130
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44633719
66ZNF263_19887448_ChIP-Seq_K562_Human1.41718380
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39734963
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39406096
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37695284
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.36490045
71P68_20966046_ChIP-Seq_HELA_Human1.35614717
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.35034992
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34750234
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34393227
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.34302475
76CREB1_26743006_Chip-Seq_LNCaP_Human1.33637669
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32834980
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.32789586
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31800363
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31701244
81* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29566697
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29015155
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28793156
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.28655639
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28644954
86AR_19668381_ChIP-Seq_PC3_Human1.28149484
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.28127871
88* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27937295
89KDM2B_26808549_Chip-Seq_K562_Human1.27711990
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27168314
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26686743
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25116223
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.24918853
94AR_25329375_ChIP-Seq_VCAP_Human1.24760419
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23113710
96P300_19829295_ChIP-Seq_ESCs_Human1.22480848
97* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21990229
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21984332
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.21775470
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20952591
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20842090
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20821088
103SPI1_23127762_ChIP-Seq_K562_Human1.20140736
104ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19915228
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19687282
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19569520
107* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18516647
108MAF_26560356_Chip-Seq_TH1_Human1.18371054
109* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18041317
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17980865
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.17844213
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.17627390
113ESR1_21235772_ChIP-Seq_MCF-7_Human1.17572265
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17277495
115IGF1R_20145208_ChIP-Seq_DFB_Human1.16874061
116STAT3_23295773_ChIP-Seq_U87_Human1.16593184
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.16267859
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13746864
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13379720
120OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11716171
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11042777
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10845857
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10643640
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10303179
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10227626
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.10077575
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09677480
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08377667
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07435952
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06968784
131ATF3_27146783_Chip-Seq_COLON_Human1.05857848
132TP53_22127205_ChIP-Seq_IMR90_Human1.05316159
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.05108040
134AHR_22903824_ChIP-Seq_MCF-7_Human1.05075800
135CBX2_27304074_Chip-Seq_ESCs_Mouse1.04905693
136TRIM28_21343339_ChIP-Seq_HEK293_Human1.03735932
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03126276
138CTCF_27219007_Chip-Seq_Bcells_Human1.02918308
139NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02484071
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01893602
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01569811
142GATA1_19941826_ChIP-Seq_K562_Human1.01458967
143TCF4_23295773_ChIP-Seq_U87_Human1.01160249
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00820695
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99833267
146RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99383388
147UTX_26944678_Chip-Seq_JUKART_Human0.98992736
148BCOR_27268052_Chip-Seq_Bcells_Human0.98060135
149GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97335138
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97314107
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.95463602
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94915622
153* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94910407
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.94562235
155TP63_22573176_ChIP-Seq_HFKS_Human0.94355822
156* MAF_26560356_Chip-Seq_TH2_Human0.94308511
157P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93895449
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93810882
159EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93733115
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.93173064
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.92081378
162IRF8_27001747_Chip-Seq_BMDM_Mouse0.92003782
163SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91904271
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91811408
165UBF1/2_26484160_Chip-Seq_HMECs_Human0.91785501
166BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91615840
167* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91493492
168RUNX2_22187159_ChIP-Seq_PCA_Human0.90961342
169ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88950478
170RNF2_27304074_Chip-Seq_NSC_Mouse0.88515971
171POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88098478
172ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88052410
173NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87682154
174KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87396076
175BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85327129
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83110373
177TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82687612
178TP53_16413492_ChIP-PET_HCT116_Human0.82252717
179TP53_18474530_ChIP-ChIP_U2OS_Human0.82045881
180TET1_21490601_ChIP-Seq_MESCs_Mouse0.81709186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43046543
2MP0003880_abnormal_central_pattern4.69559365
3MP0003705_abnormal_hypodermis_morpholog4.24024307
4* MP0003635_abnormal_synaptic_transmissio4.23559888
5MP0004270_analgesia3.68595470
6MP0002063_abnormal_learning/memory/cond3.36153174
7MP0009745_abnormal_behavioral_response3.35283919
8MP0005058_abnormal_lysosome_morphology3.22068167
9MP0002064_seizures3.16737459
10MP0009046_muscle_twitch3.15775210
11MP0005423_abnormal_somatic_nervous2.99905836
12MP0001968_abnormal_touch/_nociception2.87562265
13MP0008260_abnormal_autophagy2.84436715
14MP0005451_abnormal_body_composition2.81155019
15MP0005409_darkened_coat_color2.80620753
16MP0003191_abnormal_cellular_cholesterol2.77928765
17MP0002572_abnormal_emotion/affect_behav2.72759134
18MP0002734_abnormal_mechanical_nocicepti2.60918465
19MP0002822_catalepsy2.57040715
20MP0002272_abnormal_nervous_system2.45333808
21* MP0001486_abnormal_startle_reflex2.38341777
22MP0009840_abnormal_foam_cell2.34935249
23MP0009780_abnormal_chondrocyte_physiolo2.33439964
24MP0003436_decreased_susceptibility_to2.27393665
25MP0003566_abnormal_cell_adhesion2.20123286
26MP0002735_abnormal_chemical_nociception2.19127165
27MP0001501_abnormal_sleep_pattern2.14594888
28MP0002736_abnormal_nociception_after2.12398872
29MP0001440_abnormal_grooming_behavior2.09862666
30MP0002733_abnormal_thermal_nociception2.09335903
31MP0001849_ear_inflammation2.06141412
32MP0003300_gastrointestinal_ulcer2.05236285
33MP0002877_abnormal_melanocyte_morpholog2.03363958
34MP0003329_amyloid_beta_deposits1.99633976
35MP0008569_lethality_at_weaning1.97687896
36MP0002909_abnormal_adrenal_gland1.95463869
37* MP0002067_abnormal_sensory_capabilities1.95385428
38MP0002184_abnormal_innervation1.95044259
39MP0001970_abnormal_pain_threshold1.93779310
40MP0003453_abnormal_keratinocyte_physiol1.92567356
41MP0000778_abnormal_nervous_system1.92440327
42MP0004811_abnormal_neuron_physiology1.88823405
43MP0004858_abnormal_nervous_system1.83067819
44MP0005076_abnormal_cell_differentiation1.81422555
45MP0002557_abnormal_social/conspecific_i1.76478050
46MP0000569_abnormal_digit_pigmentation1.72932862
47MP0003091_abnormal_cell_migration1.72880790
48MP0004947_skin_inflammation1.71725025
49* MP0004924_abnormal_behavior1.70483092
50* MP0005386_behavior/neurological_phenoty1.70483092
51MP0003123_paternal_imprinting1.70247277
52MP0006276_abnormal_autonomic_nervous1.65925388
53MP0000955_abnormal_spinal_cord1.58212578
54MP0001348_abnormal_lacrimal_gland1.48668145
55MP0002796_impaired_skin_barrier1.47983958
56* MP0002882_abnormal_neuron_morphology1.47813018
57MP0004885_abnormal_endolymph1.44737098
58MP0003787_abnormal_imprinting1.43557223
59MP0003122_maternal_imprinting1.41768445
60MP0003879_abnormal_hair_cell1.40664672
61* MP0002066_abnormal_motor_capabilities/c1.40467594
62MP0001984_abnormal_olfaction1.36574850
63MP0000858_altered_metastatic_potential1.36361655
64* MP0005551_abnormal_eye_electrophysiolog1.35210533
65MP0003633_abnormal_nervous_system1.34523186
66MP0001502_abnormal_circadian_rhythm1.34361201
67MP0002419_abnormal_innate_immunity1.33014294
68MP0005646_abnormal_pituitary_gland1.30347755
69MP0009278_abnormal_bone_marrow1.30257112
70MP0004185_abnormal_adipocyte_glucose1.28544461
71MP0002998_abnormal_bone_remodeling1.27109138
72MP0001958_emphysema1.26713654
73MP0003183_abnormal_peptide_metabolism1.26000017
74MP0004264_abnormal_extraembryonic_tissu1.20264002
75MP0005257_abnormal_intraocular_pressure1.20013859
76MP0001533_abnormal_skeleton_physiology1.16367170
77MP0002152_abnormal_brain_morphology1.15794908
78MP0000013_abnormal_adipose_tissue1.14269541
79MP0005025_abnormal_response_to1.12588473
80MP0003631_nervous_system_phenotype1.10681621
81MP0005166_decreased_susceptibility_to1.10391496
82MP0005645_abnormal_hypothalamus_physiol1.09601796
83MP0005464_abnormal_platelet_physiology1.08840349
84MP0000751_myopathy1.07244144
85MP0000579_abnormal_nail_morphology1.07216255
86MP0001529_abnormal_vocalization1.06149604
87MP0008961_abnormal_basal_metabolism1.05905621
88MP0005023_abnormal_wound_healing1.03913946
89MP0006082_CNS_inflammation1.03859662
90MP0002089_abnormal_postnatal_growth/wei1.03115913
91MP0004142_abnormal_muscle_tone1.02885514
92MP0000678_abnormal_parathyroid_gland1.02295685
93MP0000604_amyloidosis1.01426671
94* MP0002229_neurodegeneration1.00955783
95MP0001905_abnormal_dopamine_level1.00270339
96MP0003828_pulmonary_edema0.97563864
97MP0010386_abnormal_urinary_bladder0.96341538
98MP0003283_abnormal_digestive_organ0.95269771
99MP0010234_abnormal_vibrissa_follicle0.94279563
100MP0002069_abnormal_eating/drinking_beha0.93400134
101MP0008874_decreased_physiological_sensi0.92750047
102MP0008438_abnormal_cutaneous_collagen0.92310521
103MP0004510_myositis0.91424175
104MP0001177_atelectasis0.90732358
105MP0004742_abnormal_vestibular_system0.90644048
106MP0008872_abnormal_physiological_respon0.90516173
107* MP0003634_abnormal_glial_cell0.88800160
108* MP0002090_abnormal_vision0.88612627
109MP0005666_abnormal_adipose_tissue0.86557095
110MP0001188_hyperpigmentation0.84940263
111MP0005394_taste/olfaction_phenotype0.84664021
112MP0005499_abnormal_olfactory_system0.84664021
113MP0005535_abnormal_body_temperature0.84145397
114MP0005000_abnormal_immune_tolerance0.83396363
115MP0002896_abnormal_bone_mineralization0.82984869
116MP0003724_increased_susceptibility_to0.82610397
117MP0003279_aneurysm0.82267478
118MP0005501_abnormal_skin_physiology0.82125427
119MP0004085_abnormal_heartbeat0.81756569
120MP0006072_abnormal_retinal_apoptosis0.81347020
121MP0001851_eye_inflammation0.80994849
122MP0000343_altered_response_to0.80924656
123MP0005187_abnormal_penis_morphology0.80873674
124MP0003172_abnormal_lysosome_physiology0.80836093
125MP0004381_abnormal_hair_follicle0.78962037
126MP0003632_abnormal_nervous_system0.78507944
127MP0004233_abnormal_muscle_weight0.78046789
128MP0003866_abnormal_defecation0.77878574
129* MP0002752_abnormal_somatic_nervous0.76835652
130MP0003075_altered_response_to0.76758659
131MP0002837_dystrophic_cardiac_calcinosis0.76611015
132MP0010155_abnormal_intestine_physiology0.76246371
133MP0002638_abnormal_pupillary_reflex0.76018042
134MP0005387_immune_system_phenotype0.75932048
135MP0001790_abnormal_immune_system0.75932048
136MP0000685_abnormal_immune_system0.75817805
137MP0002060_abnormal_skin_morphology0.75046605
138MP0000631_abnormal_neuroendocrine_gland0.75004586
139MP0003303_peritoneal_inflammation0.74237494
140MP0003690_abnormal_glial_cell0.73657068
141MP0004215_abnormal_myocardial_fiber0.73366202
142MP0005621_abnormal_cell_physiology0.72990183
143MP0001216_abnormal_epidermal_layer0.72925019
144MP0005623_abnormal_meninges_morphology0.72821208
145MP0003448_altered_tumor_morphology0.72328953
146MP0004145_abnormal_muscle_electrophysio0.72147585
147MP0005375_adipose_tissue_phenotype0.69638390
148MP0005310_abnormal_salivary_gland0.69630234
149MP0005253_abnormal_eye_physiology0.68903718
150MP0004484_altered_response_of0.68726809
151MP0003045_fibrosis0.68469819
152MP0001915_intracranial_hemorrhage0.66125995
153MP0000920_abnormal_myelination0.65130411
154MP0004130_abnormal_muscle_cell0.65075875
155MP0001819_abnormal_immune_cell0.63942531
156MP0002420_abnormal_adaptive_immunity0.63736543
157MP0001299_abnormal_eye_distance/0.63463374
158MP0003137_abnormal_impulse_conducting0.62372507
159MP0000681_abnormal_thyroid_gland0.61408069
160MP0001943_abnormal_respiration0.61350300
161MP0003861_abnormal_nervous_system0.60734152
162* MP0001963_abnormal_hearing_physiology0.60191035
163MP0005165_increased_susceptibility_to0.59927953
164MP0002148_abnormal_hypersensitivity_rea0.59449196
165MP0009785_altered_susceptibility_to0.58868967
166MP0002452_abnormal_antigen_presenting0.58472041
167MP0000767_abnormal_smooth_muscle0.58073295
168MP0010769_abnormal_survival0.57423862
169MP0005167_abnormal_blood-brain_barrier0.57097993

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.68328370
2Myokymia (HP:0002411)5.92815784
3Focal seizures (HP:0007359)5.36503209
4* Visual hallucinations (HP:0002367)4.54827694
5Epileptic encephalopathy (HP:0200134)4.35810924
6Progressive cerebellar ataxia (HP:0002073)4.31121451
7Atonic seizures (HP:0010819)4.21356526
8Absence seizures (HP:0002121)4.10586255
9Febrile seizures (HP:0002373)3.96237617
10Action tremor (HP:0002345)3.87022708
11Supranuclear gaze palsy (HP:0000605)3.79822259
12Mutism (HP:0002300)3.75073943
13Ankle clonus (HP:0011448)3.67333243
14Dialeptic seizures (HP:0011146)3.62995906
15Generalized tonic-clonic seizures (HP:0002069)3.61114112
16Papilledema (HP:0001085)3.44159959
17Poor eye contact (HP:0000817)3.22300872
18Broad-based gait (HP:0002136)3.21574768
19Truncal ataxia (HP:0002078)3.14653193
20Impaired social interactions (HP:0000735)3.09370734
21Abnormal social behavior (HP:0012433)3.09370734
22Obstructive sleep apnea (HP:0002870)3.07738928
23Urinary bladder sphincter dysfunction (HP:0002839)3.05500888
24Dysdiadochokinesis (HP:0002075)2.98355809
25* Depression (HP:0000716)2.97533334
26Impaired vibration sensation in the lower limbs (HP:0002166)2.95196048
27Eczematoid dermatitis (HP:0000976)2.92264142
28Genetic anticipation (HP:0003743)2.88491396
29Gaze-evoked nystagmus (HP:0000640)2.85445815
30Hyperacusis (HP:0010780)2.85303707
31Abnormal eating behavior (HP:0100738)2.84074457
32Urinary urgency (HP:0000012)2.84068903
33Excessive salivation (HP:0003781)2.77852617
34Drooling (HP:0002307)2.77852617
35Postural instability (HP:0002172)2.77616376
36Anxiety (HP:0000739)2.76146716
37Progressive inability to walk (HP:0002505)2.75073488
38Amblyopia (HP:0000646)2.68506074
39Cerebral inclusion bodies (HP:0100314)2.68337964
40Limb dystonia (HP:0002451)2.67305867
41Dysmetria (HP:0001310)2.66773444
42Cerebral aneurysm (HP:0004944)2.64299600
43Termporal pattern (HP:0011008)2.62641506
44Insidious onset (HP:0003587)2.62641506
45Abnormality of binocular vision (HP:0011514)2.62239405
46Diplopia (HP:0000651)2.62239405
47Impaired smooth pursuit (HP:0007772)2.56261733
48Abnormality of liposaccharide metabolism (HP:0010968)2.53708005
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.53708005
50Abnormality of glycolipid metabolism (HP:0010969)2.53708005
51Hemiplegia (HP:0002301)2.51638264
52Neurofibrillary tangles (HP:0002185)2.51159125
53Spastic gait (HP:0002064)2.50608447
54Scanning speech (HP:0002168)2.49589154
55Amyotrophic lateral sclerosis (HP:0007354)2.48514958
56Hemiparesis (HP:0001269)2.47597158
57Abnormality of the lower motor neuron (HP:0002366)2.46891262
58Dysostosis multiplex (HP:0000943)2.44443861
59Stereotypic behavior (HP:0000733)2.40978462
60Hyperventilation (HP:0002883)2.40566297
61Upper limb amyotrophy (HP:0009129)2.40341654
62Distal upper limb amyotrophy (HP:0007149)2.40341654
63Torticollis (HP:0000473)2.40023128
64Dysmetric saccades (HP:0000641)2.39396604
65Central scotoma (HP:0000603)2.38485939
66Inappropriate behavior (HP:0000719)2.37737046
67Bradykinesia (HP:0002067)2.37586701
68Abnormality of the corticospinal tract (HP:0002492)2.37302516
69Pheochromocytoma (HP:0002666)2.36907936
70Abnormality of macrophages (HP:0004311)2.36407656
71Agitation (HP:0000713)2.35569563
72Epileptiform EEG discharges (HP:0011182)2.34763737
73Intention tremor (HP:0002080)2.33220961
74EEG with generalized epileptiform discharges (HP:0011198)2.32528612
75Distal lower limb amyotrophy (HP:0008944)2.30471797
76Fetal akinesia sequence (HP:0001989)2.29997911
77Abnormality of ocular smooth pursuit (HP:0000617)2.28131319
78Vertebral compression fractures (HP:0002953)2.25646958
79Pointed chin (HP:0000307)2.25484756
80Polyphagia (HP:0002591)2.25416288
81Thin bony cortex (HP:0002753)2.23920123
82Axonal loss (HP:0003447)2.23676983
83Broad face (HP:0000283)2.23252487
84Apathy (HP:0000741)2.23120876
85Hypsarrhythmia (HP:0002521)2.22651807
86Megalencephaly (HP:0001355)2.21621925
87Lower limb muscle weakness (HP:0007340)2.21397597
88Flat acetabular roof (HP:0003180)2.16133588
89Protrusio acetabuli (HP:0003179)2.14654511
90Focal dystonia (HP:0004373)2.14205207
91Amyloidosis (HP:0011034)2.14194421
92Insomnia (HP:0100785)2.14152267
93Achilles tendon contracture (HP:0001771)2.13873019
94Hyperparathyroidism (HP:0000843)2.13236392
95Absent speech (HP:0001344)2.12877309
96Hypoventilation (HP:0002791)2.12615524
97Distal lower limb muscle weakness (HP:0009053)2.11846307
98Cellulitis (HP:0100658)2.10675240
99Neuronal loss in central nervous system (HP:0002529)2.10492647
100Annular pancreas (HP:0001734)2.10363514
101Loss of speech (HP:0002371)2.06846462
102Ventricular fibrillation (HP:0001663)2.06456724
103Generalized myoclonic seizures (HP:0002123)2.03314798
104Status epilepticus (HP:0002133)2.03158138
105Recurrent bacterial skin infections (HP:0005406)2.02965633
106Neuroendocrine neoplasm (HP:0100634)2.01771042
107Failure to thrive in infancy (HP:0001531)2.01484939
108Urinary glycosaminoglycan excretion (HP:0003541)2.00810028
109Mucopolysacchariduria (HP:0008155)2.00810028
110Diminished motivation (HP:0000745)2.00370628
111Recurrent abscess formation (HP:0002722)2.00203136
112Interstitial pulmonary disease (HP:0006530)2.00010377
113Inability to walk (HP:0002540)1.99049894
114Hand muscle atrophy (HP:0009130)1.97693758
115Akinesia (HP:0002304)1.97441660
116Increased connective tissue (HP:0009025)1.97395403
117Clonus (HP:0002169)1.96443241
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95750147
119Gingivitis (HP:0000230)1.94571641
120Slow saccadic eye movements (HP:0000514)1.94555218
121Lower limb asymmetry (HP:0100559)1.94396207
122Deep venous thrombosis (HP:0002625)1.92138529
123Abnormality of polysaccharide metabolism (HP:0011012)1.90681514
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90681514
125Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90681514
126Impaired vibratory sensation (HP:0002495)1.90220220
127Abnormality of the Achilles tendon (HP:0005109)1.90180123
128Craniofacial dystonia (HP:0012179)1.89690932
129Lower limb amyotrophy (HP:0007210)1.89350326
130Arterial tortuosity (HP:0005116)1.89063462
131Atrophic scars (HP:0001075)1.87505848
132Centrally nucleated skeletal muscle fibers (HP:0003687)1.86130390
133Segmental peripheral demyelination/remyelination (HP:0003481)1.84960261
134Hypercortisolism (HP:0001578)1.84511560
135Abnormality of macular pigmentation (HP:0008002)1.83525854
136Ankyloglossia (HP:0010296)1.82531861
137Abnormality of salivation (HP:0100755)1.82058550
138Polygenic inheritance (HP:0010982)1.81926287
139Macroorchidism (HP:0000053)1.81876429
140Gait ataxia (HP:0002066)1.81771037
141Long palpebral fissure (HP:0000637)1.81037182
142Premature rupture of membranes (HP:0001788)1.80353354
143Psychosis (HP:0000709)1.80136595
144Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78984055
145Short nail (HP:0001799)1.78117657
146Postural tremor (HP:0002174)1.77666874
147Difficulty climbing stairs (HP:0003551)1.76882761
148Decreased motor nerve conduction velocity (HP:0003431)1.76578952
149Intellectual disability, profound (HP:0002187)1.75280941
150Fragile skin (HP:0001030)1.74844682
151Rigidity (HP:0002063)1.74182639
152Mitral regurgitation (HP:0001653)1.72569466
153Upper motor neuron abnormality (HP:0002127)1.70880010
154Nuclear cataract (HP:0100018)1.70760288
155Vascular tortuosity (HP:0004948)1.70701464
156Onion bulb formation (HP:0003383)1.69938213
157Distal sensory impairment (HP:0002936)1.69473027
158Pathologic fracture (HP:0002756)1.69457432
159Bone pain (HP:0002653)1.69308590
160Hemorrhage of the eye (HP:0011885)1.68179591
161Supernumerary nipples (HP:0002558)1.67757186
162Peripheral hypomyelination (HP:0007182)1.66604071
163Spinal cord compression (HP:0002176)1.66120422
164Recurrent gram-negative bacterial infections (HP:0005420)1.65741295
165Increased IgE level (HP:0003212)1.65486853
166Disproportionate tall stature (HP:0001519)1.62237897
167* Rapidly progressive (HP:0003678)1.61666435
168Ulnar bowing (HP:0003031)1.59960461
169Abnormality of oral frenula (HP:0000190)1.59832057
170Growth hormone excess (HP:0000845)1.58832577
171Abnormality of nail color (HP:0100643)1.58203307
172Aneurysm (HP:0002617)1.57649210
173Foot dorsiflexor weakness (HP:0009027)1.57395141
174* Dementia (HP:0000726)1.57325581
175Systemic lupus erythematosus (HP:0002725)1.56923417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.18708228
2NTRK34.10398348
3MAP3K93.93519376
4EPHA43.23187712
5MAP3K43.04738754
6MINK12.90349604
7ICK2.36593509
8MAP2K72.33812183
9KSR22.33153193
10PAK62.33052349
11ERN12.30065641
12DAPK22.20611037
13IRAK32.20135132
14NTRK22.19509426
15MAP3K122.19394341
16SIK12.18674916
17SMG12.09277165
18CAMKK11.93957728
19MAP2K41.92818427
20NTRK11.91697825
21RIPK41.82133983
22SIK21.81977376
23KSR11.76815803
24EPHA21.68001830
25PRKD31.63287194
26MAP3K111.60281252
27CDK51.57526523
28EEF2K1.50203158
29PNCK1.48770558
30MAP2K31.43321375
31MAP3K21.39638665
32FGFR41.35650952
33MAPK131.33929970
34FES1.31947346
35PHKG21.31361444
36PHKG11.31361444
37PLK21.29500828
38MAP3K31.29286511
39GRK51.27072900
40STK381.25213840
41PDGFRA1.23963083
42DAPK11.23690412
43EPHB11.21128131
44RET1.20459163
45TTN1.15589894
46CDK121.14805389
47PRKCH1.13215933
48PRKCG1.09513260
49CAMKK21.08743548
50TNIK1.07232252
51TESK11.04861417
52PTK61.04650364
53TYRO31.04616751
54UHMK11.04095516
55CASK1.03194380
56PRKD21.02437655
57TAOK21.02287726
58LATS21.00590003
59CDK191.00256100
60SCYL20.99929641
61STK110.97821389
62IRAK20.97190797
63ALK0.96754259
64PAK30.94777540
65CSNK1G20.91754934
66RIPK10.91406390
67TAOK10.90142395
68PTK20.88533688
69CAMK2A0.88397531
70CDK140.87691999
71CDK180.87539519
72CDK150.87419350
73SGK4940.87369376
74SGK2230.87369376
75CAMK1G0.87329251
76PRPF4B0.87038442
77CSK0.84618610
78ZAP700.83458038
79DYRK1A0.82021621
80MAP3K130.81176907
81BLK0.81132939
82BRAF0.80529413
83CAMK10.78801141
84SGK20.77201641
85TYK20.77178353
86PAK40.76685730
87NME20.76684260
88IRAK40.76666848
89SGK30.76572996
90ARAF0.75732557
91CDK11A0.75196747
92MAP4K10.74318769
93MST1R0.74222687
94RAF10.73452112
95LMTK20.72436284
96ERBB30.72204515
97DDR20.71748204
98TESK20.71246501
99MOS0.70828106
100MARK20.69598114
101CAMK1D0.68881070
102MTOR0.68103839
103MAP3K10.65268433
104TBK10.64323949
105PRKCZ0.61925526
106JAK10.61057372
107CAMK2B0.60882689
108PRKG20.60592138
109FER0.58950553
110RPS6KA20.58879430
111* SGK10.58841196
112PDK10.57759089
113TRIB30.57032038
114FYN0.56905775
115GRK60.55337961
116NEK60.52158008
117PTK2B0.51723435
118PRKCE0.51702085
119FGFR30.51451019
120MAP3K140.50647907
121PDPK10.49732349
122WNK10.49089966
123TNK20.48870895
124LRRK20.48650744
125MAP2K10.48625926
126PDGFRB0.47400915
127JAK20.47071957
128* RPS6KA30.46556083
129RPS6KC10.46430224
130RPS6KL10.46430224
131MAPK100.45063105
132HIPK20.44960040
133PKN20.42457636
134FGFR20.42339678
135CDC42BPA0.42014854
136CAMK2D0.40116848
137MAP3K70.39933308
138NEK10.39419918
139MAPK120.37722763
140PRKCB0.37477898
141CAMK40.37135973
142BMPR20.37095110
143FGR0.35996743
144MAP3K60.35651585
145ROCK20.34852988
146CSNK1G30.33318998
147PINK10.31728554
148CAMK2G0.30680629
149DAPK30.29570921

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.34242935
2Synaptic vesicle cycle_Homo sapiens_hsa047213.18282927
3GABAergic synapse_Homo sapiens_hsa047272.59521334
4Olfactory transduction_Homo sapiens_hsa047402.50929205
5Circadian entrainment_Homo sapiens_hsa047132.48594104
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46203885
7Long-term potentiation_Homo sapiens_hsa047202.42549254
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37343217
9Morphine addiction_Homo sapiens_hsa050322.37299590
10Glutamatergic synapse_Homo sapiens_hsa047242.29954940
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23860296
12Dopaminergic synapse_Homo sapiens_hsa047282.09549168
13Amphetamine addiction_Homo sapiens_hsa050312.08967781
14Salivary secretion_Homo sapiens_hsa049701.96240045
15Cholinergic synapse_Homo sapiens_hsa047251.91529504
16Other glycan degradation_Homo sapiens_hsa005111.90414850
17Insulin secretion_Homo sapiens_hsa049111.81283382
18Gastric acid secretion_Homo sapiens_hsa049711.76131239
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70777430
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66722634
21Renin secretion_Homo sapiens_hsa049241.66600192
22Long-term depression_Homo sapiens_hsa047301.66490557
23Oxytocin signaling pathway_Homo sapiens_hsa049211.60661875
24Cocaine addiction_Homo sapiens_hsa050301.56626710
25Serotonergic synapse_Homo sapiens_hsa047261.52532337
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49383996
27Taste transduction_Homo sapiens_hsa047421.47630333
28GnRH signaling pathway_Homo sapiens_hsa049121.45552379
29Chronic myeloid leukemia_Homo sapiens_hsa052201.45222808
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42868319
31Gap junction_Homo sapiens_hsa045401.39774597
32Osteoclast differentiation_Homo sapiens_hsa043801.39330238
33Acute myeloid leukemia_Homo sapiens_hsa052211.38340797
34Phototransduction_Homo sapiens_hsa047441.37474360
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36833142
36Calcium signaling pathway_Homo sapiens_hsa040201.33327204
37B cell receptor signaling pathway_Homo sapiens_hsa046621.31936290
38Type II diabetes mellitus_Homo sapiens_hsa049301.28169365
39Collecting duct acid secretion_Homo sapiens_hsa049661.27830836
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26925717
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23945496
42Estrogen signaling pathway_Homo sapiens_hsa049151.23394318
43Glioma_Homo sapiens_hsa052141.22120375
44Lysosome_Homo sapiens_hsa041421.20434000
45cAMP signaling pathway_Homo sapiens_hsa040241.17192587
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17190886
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.14852038
48Pancreatic cancer_Homo sapiens_hsa052121.14304005
49Axon guidance_Homo sapiens_hsa043601.13841298
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12598986
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11892073
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11725779
53Notch signaling pathway_Homo sapiens_hsa043301.10553323
54ErbB signaling pathway_Homo sapiens_hsa040121.07013226
55Bladder cancer_Homo sapiens_hsa052191.06922668
56Amoebiasis_Homo sapiens_hsa051461.02778501
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.02692332
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02373355
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00938052
60Melanogenesis_Homo sapiens_hsa049160.99267776
61Tuberculosis_Homo sapiens_hsa051520.99059448
62Salmonella infection_Homo sapiens_hsa051320.98519978
63Hepatitis C_Homo sapiens_hsa051600.92462212
64Leishmaniasis_Homo sapiens_hsa051400.90509866
65Vibrio cholerae infection_Homo sapiens_hsa051100.89644973
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.89002414
67Dorso-ventral axis formation_Homo sapiens_hsa043200.88947798
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88685107
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.85736922
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85351251
71Dilated cardiomyopathy_Homo sapiens_hsa054140.81805493
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81583081
73Focal adhesion_Homo sapiens_hsa045100.81548147
74Proteoglycans in cancer_Homo sapiens_hsa052050.81277997
75HIF-1 signaling pathway_Homo sapiens_hsa040660.80835256
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80172215
77Cardiac muscle contraction_Homo sapiens_hsa042600.80019248
78TNF signaling pathway_Homo sapiens_hsa046680.78871591
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78663678
80Oocyte meiosis_Homo sapiens_hsa041140.78236041
81Toxoplasmosis_Homo sapiens_hsa051450.77908175
82Thyroid cancer_Homo sapiens_hsa052160.76940215
83Endometrial cancer_Homo sapiens_hsa052130.76661921
84Thyroid hormone synthesis_Homo sapiens_hsa049180.76404467
85Phagosome_Homo sapiens_hsa041450.75789924
86Pancreatic secretion_Homo sapiens_hsa049720.75766667
87MAPK signaling pathway_Homo sapiens_hsa040100.75549789
88Shigellosis_Homo sapiens_hsa051310.75224522
89VEGF signaling pathway_Homo sapiens_hsa043700.74987313
90Choline metabolism in cancer_Homo sapiens_hsa052310.74878149
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.74589656
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74540003
93mTOR signaling pathway_Homo sapiens_hsa041500.71274393
94T cell receptor signaling pathway_Homo sapiens_hsa046600.68494043
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68483432
96Hepatitis B_Homo sapiens_hsa051610.68439092
97Vitamin B6 metabolism_Homo sapiens_hsa007500.66290006
98Apoptosis_Homo sapiens_hsa042100.64819617
99Renal cell carcinoma_Homo sapiens_hsa052110.64064229
100Galactose metabolism_Homo sapiens_hsa000520.63875227
101Pertussis_Homo sapiens_hsa051330.63308794
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63008871
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62838867
104Fructose and mannose metabolism_Homo sapiens_hsa000510.62377179
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.61870846
106Non-small cell lung cancer_Homo sapiens_hsa052230.61370800
107AMPK signaling pathway_Homo sapiens_hsa041520.60441086
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60374582
109Endocytosis_Homo sapiens_hsa041440.58886594
110Influenza A_Homo sapiens_hsa051640.57983949
111Rap1 signaling pathway_Homo sapiens_hsa040150.57712201
112Glucagon signaling pathway_Homo sapiens_hsa049220.57189657
113Ras signaling pathway_Homo sapiens_hsa040140.57113252
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56705159
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54940627
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53215378
117Type I diabetes mellitus_Homo sapiens_hsa049400.52990691
118Colorectal cancer_Homo sapiens_hsa052100.52690358
119Insulin signaling pathway_Homo sapiens_hsa049100.52106208
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51893426
121Chemokine signaling pathway_Homo sapiens_hsa040620.51768122
122Inositol phosphate metabolism_Homo sapiens_hsa005620.51757395
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51570102
124Alcoholism_Homo sapiens_hsa050340.50170262
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50145348
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48515283
127Nitrogen metabolism_Homo sapiens_hsa009100.47571230
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46315574
129Prolactin signaling pathway_Homo sapiens_hsa049170.43363805
130Platelet activation_Homo sapiens_hsa046110.43026840
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.42599407
132Prion diseases_Homo sapiens_hsa050200.42310306
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41325164
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40763975
135Wnt signaling pathway_Homo sapiens_hsa043100.38143692
136Bile secretion_Homo sapiens_hsa049760.37081369
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37075136
138Circadian rhythm_Homo sapiens_hsa047100.35768449
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35155837
140Ovarian steroidogenesis_Homo sapiens_hsa049130.29288794

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