DNAJC5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins that is characterized by an N-terminal DNAJ domain, a linker region, and a cysteine-rich C-terminal domain. The encoded protein, together with heat shock protein 70, is thought to regulate the proper folding of other proteins. The orthologous mouse protein is membrane-associated and is targeted to the trans-golgi network. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.86270975
2epithelial cilium movement (GO:0003351)9.81886792
3axonemal dynein complex assembly (GO:0070286)9.74720365
4spermatid development (GO:0007286)9.42932235
5cilium or flagellum-dependent cell motility (GO:0001539)9.19749255
6motile cilium assembly (GO:0044458)9.03648405
7regulation of cilium movement (GO:0003352)8.15073514
8cilium movement (GO:0003341)8.11025346
9single fertilization (GO:0007338)7.71888590
10male meiosis (GO:0007140)7.66248134
11piRNA metabolic process (GO:0034587)7.47161396
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.43033673
13synaptonemal complex organization (GO:0070193)7.17900937
14sperm capacitation (GO:0048240)7.16114981
15synaptonemal complex assembly (GO:0007130)7.10333002
16negative regulation of inclusion body assembly (GO:0090084)6.71796931
17spermatogenesis (GO:0007283)6.55815850
18microtubule depolymerization (GO:0007019)6.55095512
19male gamete generation (GO:0048232)6.53631389
20fertilization (GO:0009566)6.53206670
21gamete generation (GO:0007276)6.08319790
22organic cation transport (GO:0015695)5.95320885
23regulation of inclusion body assembly (GO:0090083)5.55134281
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.33329628
25germ cell development (GO:0007281)5.29900772
26calcium ion-dependent exocytosis (GO:0017156)5.25136909
27microtubule severing (GO:0051013)5.20170652
28spermatid nucleus differentiation (GO:0007289)5.16590397
29behavioral response to nicotine (GO:0035095)5.08644558
30male meiosis I (GO:0007141)4.98829762
31cell recognition (GO:0008037)4.93011089
32ventricular system development (GO:0021591)4.90629342
33chromosome organization involved in meiosis (GO:0070192)4.89800133
34DNA methylation involved in gamete generation (GO:0043046)4.89312114
35chromosome condensation (GO:0030261)4.81421136
36multicellular organismal reproductive process (GO:0048609)4.77809061
37regulation of microtubule-based movement (GO:0060632)4.74447497
38glycerol ether metabolic process (GO:0006662)4.71688305
39DNA packaging (GO:0006323)4.47968750
40meiotic nuclear division (GO:0007126)4.46347037
41seminiferous tubule development (GO:0072520)4.43761508
42ether metabolic process (GO:0018904)4.35483531
43L-fucose catabolic process (GO:0042355)4.28367412
44fucose catabolic process (GO:0019317)4.28367412
45L-fucose metabolic process (GO:0042354)4.28367412
46pyrimidine nucleobase catabolic process (GO:0006208)4.23881414
47monoubiquitinated protein deubiquitination (GO:0035520)4.20135288
48meiosis I (GO:0007127)4.06920619
49single strand break repair (GO:0000012)4.06564858
50response to pheromone (GO:0019236)3.86701331
51left/right pattern formation (GO:0060972)3.81182999
52negative regulation of telomere maintenance (GO:0032205)3.79717650
53multicellular organismal development (GO:0007275)3.77557643
54meiotic cell cycle (GO:0051321)3.75003783
55sexual reproduction (GO:0019953)3.74963847
56protein polyglutamylation (GO:0018095)3.73644220
57platelet dense granule organization (GO:0060155)3.72955287
58cellular ketone body metabolic process (GO:0046950)3.69816682
59chaperone-mediated protein complex assembly (GO:0051131)3.69085016
60nucleobase catabolic process (GO:0046113)3.68640886
61microtubule polymerization or depolymerization (GO:0031109)3.62680355
62phosphatidylinositol acyl-chain remodeling (GO:0036149)3.60451422
63protein K11-linked deubiquitination (GO:0035871)3.58939615
64genitalia morphogenesis (GO:0035112)3.51307762
65regulation of spindle checkpoint (GO:0090231)3.48595148
66positive regulation of prostaglandin secretion (GO:0032308)3.43410797
67ketone body metabolic process (GO:1902224)3.30364377
68positive regulation of fatty acid transport (GO:2000193)3.28704253
69nonmotile primary cilium assembly (GO:0035058)3.26100185
70protein localization to synapse (GO:0035418)3.26006797
71sequestering of actin monomers (GO:0042989)3.22543340
72synaptic transmission, cholinergic (GO:0007271)3.18178603
73neuronal action potential (GO:0019228)3.17164897
74nephron epithelium morphogenesis (GO:0072088)3.16412084
75nephron tubule morphogenesis (GO:0072078)3.16412084
76water-soluble vitamin biosynthetic process (GO:0042364)3.14894130
77mitotic sister chromatid cohesion (GO:0007064)3.06974283
78meiotic cell cycle process (GO:1903046)3.06008455
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.04844993
80indolalkylamine metabolic process (GO:0006586)3.04389262
81nucleus organization (GO:0006997)3.03907824
82protein refolding (GO:0042026)3.03294542
83polyol catabolic process (GO:0046174)3.01504329
84DNA deamination (GO:0045006)3.00501480
85centriole assembly (GO:0098534)2.98294974
86nucleoside diphosphate phosphorylation (GO:0006165)2.96615884
87glycolytic process (GO:0006096)2.95496140
88indole-containing compound catabolic process (GO:0042436)2.93957898
89indolalkylamine catabolic process (GO:0046218)2.93957898
90tryptophan catabolic process (GO:0006569)2.93957898
91auditory behavior (GO:0031223)2.92684950
92protein localization to cilium (GO:0061512)2.91492217
93positive regulation of icosanoid secretion (GO:0032305)2.90759385
94synapsis (GO:0007129)2.89317557
95alditol metabolic process (GO:0019400)2.87425872
96neurotransmitter catabolic process (GO:0042135)2.85826384
97GTP biosynthetic process (GO:0006183)2.85539698
98cilium organization (GO:0044782)2.85279979
99protein-cofactor linkage (GO:0018065)2.84417697
100postsynaptic membrane organization (GO:0001941)2.84058753
101centriole replication (GO:0007099)2.83654867
102phosphatidylserine acyl-chain remodeling (GO:0036150)2.82699505
103microtubule-based movement (GO:0007018)2.82017259
104alanine transport (GO:0032328)2.81538980
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.80781008
106NADH dehydrogenase complex assembly (GO:0010257)2.80781008
107mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80781008
108amino-acid betaine transport (GO:0015838)2.80688936
109carnitine transport (GO:0015879)2.80688936
110sulfation (GO:0051923)2.78433892
111cilium morphogenesis (GO:0060271)2.75988941
112cellular component assembly involved in morphogenesis (GO:0010927)2.75237467
113cilium assembly (GO:0042384)2.74834443
114intraciliary transport (GO:0042073)2.74798310
115phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.74733909
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73136102
117gene silencing by RNA (GO:0031047)2.72982115
118regulation of prostaglandin secretion (GO:0032306)2.71931668
119kynurenine metabolic process (GO:0070189)2.71400552
120basic amino acid transport (GO:0015802)2.68601754
121protein complex biogenesis (GO:0070271)2.67791850
122regulation of meiosis I (GO:0060631)2.66661118
123transmission of nerve impulse (GO:0019226)2.64842930
124carnitine transmembrane transport (GO:1902603)2.64328988
125tryptophan metabolic process (GO:0006568)2.64004690
126negative regulation of mast cell activation (GO:0033004)2.63433439
127lactate metabolic process (GO:0006089)2.62156921
128regulation of cilium assembly (GO:1902017)2.61683255
129NAD biosynthetic process (GO:0009435)2.61630933
130cAMP catabolic process (GO:0006198)2.61570677
131axoneme assembly (GO:0035082)2.59474830
132negative regulation of organelle assembly (GO:1902116)2.54847005
133neuron cell-cell adhesion (GO:0007158)2.54718072
134cornea development in camera-type eye (GO:0061303)2.53184382
135negative regulation of interleukin-1 beta production (GO:0032691)2.52936348
136response to dietary excess (GO:0002021)2.51388440
137UTP biosynthetic process (GO:0006228)2.50187149
138interferon-gamma secretion (GO:0072643)2.49176578
139glycerophospholipid catabolic process (GO:0046475)2.49170594
140neuron fate determination (GO:0048664)2.48524465
141positive regulation of macrophage activation (GO:0043032)2.47883433
142glycerol metabolic process (GO:0006071)2.47778474
143RNA destabilization (GO:0050779)2.46285556
144regulation of centriole replication (GO:0046599)2.46082702
145indole-containing compound metabolic process (GO:0042430)2.45908874
146amine catabolic process (GO:0009310)2.45650576
147cellular biogenic amine catabolic process (GO:0042402)2.45650576
148mitochondrial respiratory chain complex assembly (GO:0033108)2.45453672
149gamma-aminobutyric acid transport (GO:0015812)2.45386337
150activated T cell proliferation (GO:0050798)2.44348967
151primary amino compound metabolic process (GO:1901160)2.42922967
152neurotransmitter metabolic process (GO:0042133)2.42350359
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41823057
154ATP synthesis coupled proton transport (GO:0015986)2.41823057
155amino acid salvage (GO:0043102)2.40672967
156L-methionine salvage (GO:0071267)2.40672967
157L-methionine biosynthetic process (GO:0071265)2.40672967
158negative regulation of heart rate (GO:0010459)2.40578452
159detection of light stimulus involved in visual perception (GO:0050908)2.39709513
160detection of light stimulus involved in sensory perception (GO:0050962)2.39709513
161regulation of nuclear cell cycle DNA replication (GO:0033262)2.39330784
162negative regulation of reactive oxygen species metabolic process (GO:2000378)2.38749797
163positive regulation of organic acid transport (GO:0032892)2.38236813
164cellular response to ATP (GO:0071318)2.37669496
165regulation of action potential (GO:0098900)2.37087168
166synapse assembly (GO:0007416)2.36371561
167startle response (GO:0001964)2.35863875
168positive regulation of sodium ion transmembrane transport (GO:1902307)2.35462552
169positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.35375019
170cardiac right ventricle morphogenesis (GO:0003215)2.34865141
171fusion of sperm to egg plasma membrane (GO:0007342)13.8286408
172sperm motility (GO:0030317)13.4580762
173cell wall macromolecule catabolic process (GO:0016998)13.1197081
174cell wall macromolecule metabolic process (GO:0044036)13.1197081
175acrosome assembly (GO:0001675)11.8607319
176multicellular organism reproduction (GO:0032504)11.6093015
177sperm-egg recognition (GO:0035036)11.4656833
178acrosome reaction (GO:0007340)11.3281389
179plasma membrane fusion (GO:0045026)10.5015670
180binding of sperm to zona pellucida (GO:0007339)10.3857221
181cell-cell recognition (GO:0009988)10.2478894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.00823537
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.56389893
3EZH2_22144423_ChIP-Seq_EOC_Human3.56048677
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.01103872
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.88899412
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87514889
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.83095733
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49646366
9VDR_22108803_ChIP-Seq_LS180_Human2.44670457
10GBX2_23144817_ChIP-Seq_PC3_Human2.40015587
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.38794881
12IGF1R_20145208_ChIP-Seq_DFB_Human2.38222251
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12598578
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.10589777
15* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10292040
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.07415879
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05390720
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04278484
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.02038472
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98926341
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.98644507
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98386161
23KAP1_22055183_ChIP-Seq_ESCs_Mouse1.91492338
24P300_19829295_ChIP-Seq_ESCs_Human1.82342237
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81996095
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.81793139
27STAT1_17558387_ChIP-Seq_HELA_Human1.81600525
28RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.77759845
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73557087
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73101823
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73054251
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.69035471
33KDM2B_26808549_Chip-Seq_REH_Human1.63792030
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61940182
35TAL1_26923725_Chip-Seq_HPCs_Mouse1.61777698
36FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58925110
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.58918655
38ER_23166858_ChIP-Seq_MCF-7_Human1.58631569
39GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58450420
40EWS_26573619_Chip-Seq_HEK293_Human1.58094257
41TP53_22573176_ChIP-Seq_HFKS_Human1.51293044
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.49672629
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.48576573
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.48111922
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.47977065
46GATA3_21867929_ChIP-Seq_CD8_Mouse1.47605287
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.47507449
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46124005
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.42087787
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41776118
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41627966
52IRF1_19129219_ChIP-ChIP_H3396_Human1.40582581
53GATA3_21867929_ChIP-Seq_TH1_Mouse1.38186220
54AR_25329375_ChIP-Seq_VCAP_Human1.37348202
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37332795
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36930702
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36418265
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.35731373
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.35390731
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35191470
61CBP_20019798_ChIP-Seq_JUKART_Human1.35191470
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33803069
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33473322
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33462063
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.32389028
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32389028
67SOX2_19829295_ChIP-Seq_ESCs_Human1.31903297
68NANOG_19829295_ChIP-Seq_ESCs_Human1.31903297
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.31177057
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31024472
71TAF15_26573619_Chip-Seq_HEK293_Human1.30218972
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29606635
73AR_21572438_ChIP-Seq_LNCaP_Human1.29158764
74ERA_21632823_ChIP-Seq_H3396_Human1.28766264
75MYC_18940864_ChIP-ChIP_HL60_Human1.26987970
76* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26661404
77STAT3_23295773_ChIP-Seq_U87_Human1.26173004
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26100366
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25736568
80GF1_26923725_Chip-Seq_HPCs_Mouse1.25707397
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25641254
82P53_21459846_ChIP-Seq_SAOS-2_Human1.25536037
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25416347
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24927745
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24886886
86TAF2_19829295_ChIP-Seq_ESCs_Human1.24642758
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24547984
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24376647
89JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24205772
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24123128
91BCAT_22108803_ChIP-Seq_LS180_Human1.23710125
92FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22473048
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.22216827
94RNF2_27304074_Chip-Seq_NSC_Mouse1.21987047
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21352737
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20498516
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20498516
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20208765
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18306548
100MYC_19829295_ChIP-Seq_ESCs_Human1.18285912
101RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18005809
102REST_21632747_ChIP-Seq_MESCs_Mouse1.17701335
103SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16635963
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.16342714
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15680695
106SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15438561
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14639011
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.14457587
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11964986
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.11664644
111* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11144477
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11122216
113TCF4_23295773_ChIP-Seq_U87_Human1.10838233
114TCF4_22108803_ChIP-Seq_LS180_Human1.10633135
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10628265
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09727953
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09610064
118NCOR_22424771_ChIP-Seq_293T_Human1.09525345
119* CMYC_18555785_Chip-Seq_ESCs_Mouse1.09459101
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.09030365
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.08824865
122ERG_20517297_ChIP-Seq_VCAP_Human1.07956335
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07734299
124AR_20517297_ChIP-Seq_VCAP_Human1.07656535
125* P53_22387025_ChIP-Seq_ESCs_Mouse1.07124147
126ESET_19884257_ChIP-Seq_ESCs_Mouse1.06424922
127* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06274464
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.05691514
129SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05239529
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05140422
131RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04932113
132* HOXB7_26014856_ChIP-Seq_BT474_Human1.04218362
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03908883
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.03879101
135NANOG_20526341_ChIP-Seq_ESCs_Human1.03762810
136SMAD4_21799915_ChIP-Seq_A2780_Human1.03533204
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03153130
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02583215
139RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02434927
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02353763
141ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01662955
142* KLF4_18555785_Chip-Seq_ESCs_Mouse1.01525814
143PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01471623
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01333514
145RUNX2_22187159_ChIP-Seq_PCA_Human1.01229435
146* P300_18555785_Chip-Seq_ESCs_Mouse1.00684625
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99374442
148GF1B_26923725_Chip-Seq_HPCs_Mouse0.99259254
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99011883
150FUS_26573619_Chip-Seq_HEK293_Human0.98992905
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97921564
152SOX9_26525672_Chip-Seq_HEART_Mouse0.97695367
153NFYB_21822215_ChIP-Seq_K562_Human0.96956958
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96610990
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96566489
156* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96536752
157CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96435485
158STAT3_18555785_Chip-Seq_ESCs_Mouse0.96121040
159STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95213615
160TBL1_22424771_ChIP-Seq_293T_Human0.94547067
161LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93429708
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.93223713
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93212113
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91912763
165EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91292164
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.90965145
167* SOX2_18555785_Chip-Seq_ESCs_Mouse0.90793869
168* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90403490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.05130184
2MP0001929_abnormal_gametogenesis5.71248008
3MP0008877_abnormal_DNA_methylation4.50902756
4MP0002210_abnormal_sex_determination3.58889686
5MP0002161_abnormal_fertility/fecundity3.43121279
6MP0001145_abnormal_male_reproductive3.00340279
7MP0002653_abnormal_ependyma_morphology2.95434451
8MP0000653_abnormal_sex_gland2.74354562
9MP0005645_abnormal_hypothalamus_physiol2.69217808
10MP0006276_abnormal_autonomic_nervous2.63248964
11MP0003122_maternal_imprinting2.61107107
12MP0003195_calcinosis2.39035998
13MP0005670_abnormal_white_adipose2.32577797
14MP0003136_yellow_coat_color2.08858045
15MP0004142_abnormal_muscle_tone2.03051639
16MP0005410_abnormal_fertilization15.8908129
17MP0009745_abnormal_behavioral_response1.99266747
18MP0003646_muscle_fatigue1.88276151
19MP0008875_abnormal_xenobiotic_pharmacok1.80208977
20MP0002064_seizures1.66924734
21MP0003880_abnormal_central_pattern1.65833713
22MP0001502_abnormal_circadian_rhythm1.63362930
23MP0002733_abnormal_thermal_nociception1.63115792
24MP0002837_dystrophic_cardiac_calcinosis1.61004435
25MP0002876_abnormal_thyroid_physiology1.60496580
26MP0002272_abnormal_nervous_system1.59802563
27MP0005084_abnormal_gallbladder_morpholo1.59059534
28MP0002557_abnormal_social/conspecific_i1.58814757
29MP0001486_abnormal_startle_reflex1.58046717
30MP0008872_abnormal_physiological_respon1.57772342
31MP0002735_abnormal_chemical_nociception1.55380882
32MP0004147_increased_porphyrin_level1.52474549
33MP0004885_abnormal_endolymph1.51546551
34MP0002572_abnormal_emotion/affect_behav1.51326986
35MP0001970_abnormal_pain_threshold1.50191945
36MP0004133_heterotaxia1.49028192
37MP0001986_abnormal_taste_sensitivity1.49021340
38MP0002160_abnormal_reproductive_system1.47024878
39MP0003635_abnormal_synaptic_transmissio1.44310852
40MP0002067_abnormal_sensory_capabilities1.43154082
41MP0001905_abnormal_dopamine_level1.40435548
42MP0002638_abnormal_pupillary_reflex1.38609088
43MP0002063_abnormal_learning/memory/cond1.35849126
44MP0004924_abnormal_behavior1.35196840
45MP0005386_behavior/neurological_phenoty1.35196840
46MP0005646_abnormal_pituitary_gland1.35099729
47MP0001501_abnormal_sleep_pattern1.34499121
48MP0001440_abnormal_grooming_behavior1.33414771
49MP0005623_abnormal_meninges_morphology1.32516617
50MP0002282_abnormal_trachea_morphology1.32502153
51MP0004233_abnormal_muscle_weight1.32111930
52MP0000778_abnormal_nervous_system1.31980178
53MP0003121_genomic_imprinting1.31771574
54MP0002734_abnormal_mechanical_nocicepti1.27551044
55MP0001485_abnormal_pinna_reflex1.27349063
56MP0003283_abnormal_digestive_organ1.26026653
57MP0005423_abnormal_somatic_nervous1.25417947
58MP0000631_abnormal_neuroendocrine_gland1.23576178
59MP0005379_endocrine/exocrine_gland_phen1.18466304
60MP0002254_reproductive_system_inflammat1.17533095
61MP0005174_abnormal_tail_pigmentation1.13340444
62MP0005167_abnormal_blood-brain_barrier1.08693005
63MP0001765_abnormal_ion_homeostasis1.08253660
64MP0008058_abnormal_DNA_repair1.05607631
65MP0010386_abnormal_urinary_bladder1.05136529
66MP0002277_abnormal_respiratory_mucosa1.04503797
67MP0000566_synostosis1.03580450
68MP0002102_abnormal_ear_morphology1.03532249
69MP0005647_abnormal_sex_gland1.01062480
70MP0001919_abnormal_reproductive_system0.99620039
71MP0004043_abnormal_pH_regulation0.98148225
72MP0000026_abnormal_inner_ear0.96157132
73MP0002909_abnormal_adrenal_gland0.95730424
74MP0010094_abnormal_chromosome_stability0.95452136
75MP0000955_abnormal_spinal_cord0.94027514
76MP0002138_abnormal_hepatobiliary_system0.93088192
77MP0000427_abnormal_hair_cycle0.93016629
78MP0004859_abnormal_synaptic_plasticity0.93000214
79MP0001984_abnormal_olfaction0.92360943
80MP0001963_abnormal_hearing_physiology0.91222990
81MP0009046_muscle_twitch0.90588463
82MP0008995_early_reproductive_senescence0.90190221
83MP0003632_abnormal_nervous_system0.85863488
84MP0003950_abnormal_plasma_membrane0.84586186
85MP0005389_reproductive_system_phenotype0.84564209
86MP0003699_abnormal_female_reproductive0.84083751
87MP0002882_abnormal_neuron_morphology0.83441974
88MP0006292_abnormal_olfactory_placode0.82699381
89MP0002163_abnormal_gland_morphology0.82649589
90MP0003633_abnormal_nervous_system0.82145960
91MP0005451_abnormal_body_composition0.82092018
92MP0000372_irregular_coat_pigmentation0.81317239
93MP0002938_white_spotting0.81071321
94MP0002693_abnormal_pancreas_physiology0.80308625
95MP0000230_abnormal_systemic_arterial0.75840046
96MP0003011_delayed_dark_adaptation0.75353821
97MP0002184_abnormal_innervation0.75241682
98MP0001348_abnormal_lacrimal_gland0.74504584
99MP0001119_abnormal_female_reproductive0.66404356
100MP0002234_abnormal_pharynx_morphology0.65197171
101MP0003718_maternal_effect0.63156075
102MP0003111_abnormal_nucleus_morphology0.61085756
103MP0003878_abnormal_ear_physiology0.60840159
104MP0005377_hearing/vestibular/ear_phenot0.60840159
105MP0003115_abnormal_respiratory_system0.54482443
106MP0002736_abnormal_nociception_after0.54206306
107MP0000569_abnormal_digit_pigmentation0.51849985
108MP0005636_abnormal_mineral_homeostasis0.51693311
109MP0005666_abnormal_adipose_tissue0.50550839
110MP0005551_abnormal_eye_electrophysiolog0.50288418
111MP0001324_abnormal_eye_pigmentation0.49643185
112MP0008057_abnormal_DNA_replication0.48811247
113MP0003329_amyloid_beta_deposits0.48170313
114MP0004036_abnormal_muscle_relaxation0.47921072
115MP0005253_abnormal_eye_physiology0.46285851
116MP0002928_abnormal_bile_duct0.44659334
117MP0000534_abnormal_ureter_morphology0.44372404
118MP0001293_anophthalmia0.42319476
119MP0002269_muscular_atrophy0.41691663
120MP0003786_premature_aging0.41106357
121MP0001730_embryonic_growth_arrest0.39751546
122MP0004742_abnormal_vestibular_system0.39414295
123MP0000358_abnormal_cell_content/0.38398274
124MP0008007_abnormal_cellular_replicative0.38052503
125MP0003077_abnormal_cell_cycle0.36161835
126MP0000462_abnormal_digestive_system0.35722744
127MP0006072_abnormal_retinal_apoptosis0.35005505
128MP0005391_vision/eye_phenotype0.34235301
129MP0004270_analgesia0.33432413
130MP0001529_abnormal_vocalization0.33135431
131MP0001851_eye_inflammation0.33037067
132MP0003861_abnormal_nervous_system0.32190205
133MP0005395_other_phenotype0.29912867
134MP0010307_abnormal_tumor_latency0.29849106
135MP0001968_abnormal_touch/_nociception0.28847570
136MP0003879_abnormal_hair_cell0.28611429
137MP0002084_abnormal_developmental_patter0.27785110
138MP0006036_abnormal_mitochondrial_physio0.27783128
139MP0001764_abnormal_homeostasis0.27591151
140MP0002971_abnormal_brown_adipose0.26808860
141MP0001727_abnormal_embryo_implantation0.26628518
142MP0003942_abnormal_urinary_system0.25920834
143MP0002295_abnormal_pulmonary_circulatio0.25643547
144MP0009115_abnormal_fat_cell0.25031408
145MP0003787_abnormal_imprinting0.23949749
146MP0004145_abnormal_muscle_electrophysio0.23790429
147MP0001849_ear_inflammation0.22845654
148MP0000579_abnormal_nail_morphology0.22636742
149MP0002229_neurodegeneration0.22571093
150MP0002152_abnormal_brain_morphology0.22424497
151MP0002169_no_abnormal_phenotype0.22358060
152MP0002873_normal_phenotype0.22300803
153MP0005397_hematopoietic_system_phenotyp0.21639503
154MP0001545_abnormal_hematopoietic_system0.21639503
155MP0001697_abnormal_embryo_size0.21563341
156MP0009250_abnormal_appendicular_skeleto0.21371603
157MP0002085_abnormal_embryonic_tissue0.20456491
158MP0001672_abnormal_embryogenesis/_devel0.20197897
159MP0005380_embryogenesis_phenotype0.20197897
160MP0005195_abnormal_posterior_eye0.19268982
161MP0002139_abnormal_hepatobiliary_system0.19164069
162MP0003693_abnormal_embryo_hatching0.18263353
163MP0000604_amyloidosis0.18108260
164MP0002752_abnormal_somatic_nervous0.17956652
165MP0000920_abnormal_myelination0.17222563
166MP0000313_abnormal_cell_death0.17198786
167MP0002092_abnormal_eye_morphology0.17176473
168MP0003631_nervous_system_phenotype0.17123498
169MP0000432_abnormal_head_morphology0.16573439
170MP0001270_distended_abdomen0.16012654

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.62100894
2Abnormal respiratory motile cilium morphology (HP:0005938)8.97724493
3Abnormal respiratory epithelium morphology (HP:0012253)8.97724493
4Abnormal ciliary motility (HP:0012262)7.81928208
5Rhinitis (HP:0012384)7.46572536
6Chronic bronchitis (HP:0004469)7.46345445
7Infertility (HP:0000789)6.90456355
8Nasal polyposis (HP:0100582)5.98245761
9Male infertility (HP:0003251)5.29009918
10Abnormality of the nasal mucosa (HP:0000433)4.86616061
11Type II lissencephaly (HP:0007260)4.86260397
12Bronchitis (HP:0012387)4.46144229
13Bronchiectasis (HP:0002110)4.43186443
14Pancreatic cysts (HP:0001737)4.27841245
15Nephronophthisis (HP:0000090)4.04210103
16Abnormal spermatogenesis (HP:0008669)3.64023619
17Recurrent sinusitis (HP:0011108)3.34431455
18Congenital stationary night blindness (HP:0007642)3.32400265
19Polyphagia (HP:0002591)3.26117405
20Recurrent otitis media (HP:0000403)3.17960298
21Chronic hepatic failure (HP:0100626)3.15252866
22Attenuation of retinal blood vessels (HP:0007843)3.14387262
23Hyperventilation (HP:0002883)3.10521775
24Abnormality of the renal medulla (HP:0100957)3.05937457
25Lissencephaly (HP:0001339)3.03965923
26Hypoplasia of the pons (HP:0012110)2.87011598
27Abnormality of the pons (HP:0007361)2.78999842
28Tubulointerstitial nephritis (HP:0001970)2.76156980
29Molar tooth sign on MRI (HP:0002419)2.72503330
30Abnormality of midbrain morphology (HP:0002418)2.72503330
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68988285
32Medial flaring of the eyebrow (HP:0010747)2.62671086
33Congenital, generalized hypertrichosis (HP:0004540)2.60654718
34Pachygyria (HP:0001302)2.57260253
35Large for gestational age (HP:0001520)2.55341426
36Acute necrotizing encephalopathy (HP:0006965)2.47151466
37Recurrent bronchitis (HP:0002837)2.46010086
38Limb dystonia (HP:0002451)2.45402088
39Impulsivity (HP:0100710)2.44336885
40Tubular atrophy (HP:0000092)2.41526626
41Calf muscle hypertrophy (HP:0008981)2.39140003
42Abnormal gallbladder physiology (HP:0012438)2.38473443
43Cholecystitis (HP:0001082)2.38473443
44Azoospermia (HP:0000027)2.37737906
45Mesangial abnormality (HP:0001966)2.36696287
46Sclerocornea (HP:0000647)2.35793948
47Pendular nystagmus (HP:0012043)2.35569209
48Tubulointerstitial abnormality (HP:0001969)2.34790697
493-Methylglutaconic aciduria (HP:0003535)2.30596271
50Agitation (HP:0000713)2.29513972
51Optic disc pallor (HP:0000543)2.27630900
52Acute encephalopathy (HP:0006846)2.17215812
53Hypoplasia of the brainstem (HP:0002365)2.15193685
54Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15193685
55Abolished electroretinogram (ERG) (HP:0000550)2.14886240
56Muscle hypertrophy of the lower extremities (HP:0008968)2.14350501
57Inability to walk (HP:0002540)2.14074249
58Mitochondrial inheritance (HP:0001427)2.11619746
59Retinal dysplasia (HP:0007973)2.10728039
60Furrowed tongue (HP:0000221)2.09751890
61Severe muscular hypotonia (HP:0006829)2.09043399
62Hemiparesis (HP:0001269)2.08845276
63Progressive macrocephaly (HP:0004481)2.07819040
64Abnormal rod and cone electroretinograms (HP:0008323)2.05648040
65Broad-based gait (HP:0002136)2.05417223
66Abnormality of alanine metabolism (HP:0010916)2.05079983
67Hyperalaninemia (HP:0003348)2.05079983
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05079983
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04762900
70Abnormal mitochondria in muscle tissue (HP:0008316)2.04466833
71Renal cortical cysts (HP:0000803)2.03952989
72Poor head control (HP:0002421)2.03587284
73Dyschromatopsia (HP:0007641)2.02416274
74Male pseudohermaphroditism (HP:0000037)2.02354806
75Keratoconus (HP:0000563)2.00397321
76Increased corneal curvature (HP:0100692)2.00397321
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3825053
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.2275806
79Absent/shortened dynein arms (HP:0200106)13.2275806
80Gonadotropin excess (HP:0000837)1.99163496
81Optic nerve hypoplasia (HP:0000609)1.95367822
82Increased CSF lactate (HP:0002490)1.92994400
83Polyuria (HP:0000103)1.92920858
84Focal motor seizures (HP:0011153)1.92475151
85Large eyes (HP:0001090)1.90296365
86Abnormality of the labia minora (HP:0012880)1.88637854
87Anencephaly (HP:0002323)1.88448149
88Tubulointerstitial fibrosis (HP:0005576)1.87360465
89Decreased central vision (HP:0007663)1.87359884
90Concave nail (HP:0001598)1.84986285
91Agnosia (HP:0010524)1.83133146
92Patellar aplasia (HP:0006443)1.82237068
93Postaxial foot polydactyly (HP:0001830)1.81849054
94Stage 5 chronic kidney disease (HP:0003774)1.79433265
95Progressive cerebellar ataxia (HP:0002073)1.77635334
96Left ventricular hypertrophy (HP:0001712)1.74803683
97Abnormal biliary tract physiology (HP:0012439)1.73841776
98Bile duct proliferation (HP:0001408)1.73841776
99Occipital encephalocele (HP:0002085)1.73285363
100Birth length less than 3rd percentile (HP:0003561)1.72300017
101Aplasia/Hypoplasia of the patella (HP:0006498)1.71968298
102Hemiplegia (HP:0002301)1.70911451
103Hypomagnesemia (HP:0002917)1.70858711
104Abnormal number of erythroid precursors (HP:0012131)1.70557207
105Progressive inability to walk (HP:0002505)1.70211081
106Aplasia/hypoplasia of the uterus (HP:0008684)1.69856440
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68739976
108Hypothermia (HP:0002045)1.68140782
109Mutism (HP:0002300)1.67385386
110Inappropriate behavior (HP:0000719)1.67342062
111Spastic tetraparesis (HP:0001285)1.65243222
112Abnormality of the dental root (HP:0006486)1.65024635
113Taurodontia (HP:0000679)1.65024635
114Abnormality of permanent molar morphology (HP:0011071)1.65024635
115Abnormal drinking behavior (HP:0030082)1.62279633
116Polydipsia (HP:0001959)1.62279633
117Heterotopia (HP:0002282)1.61790637
118Choroideremia (HP:0001139)1.61690933
119Pancreatic fibrosis (HP:0100732)1.60415807
120Congenital hepatic fibrosis (HP:0002612)1.60378742
121Congenital primary aphakia (HP:0007707)1.58400751
122Gait imbalance (HP:0002141)1.58348877
123Renal dysplasia (HP:0000110)1.57819441
124Short ribs (HP:0000773)1.54816675
125Genital tract atresia (HP:0001827)1.53336495
126Abnormality of molar morphology (HP:0011070)1.53265593
127Abnormality of molar (HP:0011077)1.53265593
128Aplasia/Hypoplasia of the lens (HP:0008063)1.51275579
129Vaginal atresia (HP:0000148)1.51212574
130Abnormality of the dental pulp (HP:0006479)1.50815009
131Abnormality of renal excretion (HP:0011036)1.50348505
132Postaxial hand polydactyly (HP:0001162)1.49194278
133Microglossia (HP:0000171)1.48738041
134Oculomotor apraxia (HP:0000657)1.48515583
135Abnormality of the renal cortex (HP:0011035)1.46667086
136Bell-shaped thorax (HP:0001591)1.43599027
137Neurofibrillary tangles (HP:0002185)1.42139829
138Cystic liver disease (HP:0006706)1.42115126
139Hemorrhage of the eye (HP:0011885)1.41834556
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.38855333
141Fibular hypoplasia (HP:0003038)1.37364657
142Abnormality of dentin (HP:0010299)1.37063001
143Asymmetric septal hypertrophy (HP:0001670)1.36596840
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.34918978
145Absent epiphyses (HP:0010577)1.33446153
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33446153
147Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.33134274
148Supernumerary spleens (HP:0009799)1.33123433
149Nephrogenic diabetes insipidus (HP:0009806)1.32915534
150Sensory axonal neuropathy (HP:0003390)1.32570367
151True hermaphroditism (HP:0010459)1.31013553
152Bundle branch block (HP:0011710)1.31004664
153Facial cleft (HP:0002006)1.26102395
154Poor coordination (HP:0002370)1.25906120
155Chronic sinusitis (HP:0011109)1.23552580
156Abnormality of the lower motor neuron (HP:0002366)1.21237532
157Cerebellar dysplasia (HP:0007033)1.19186854
158Deformed sella turcica (HP:0002681)1.19091288
159Congenital malformation of the right heart (HP:0011723)1.19039468
160Double outlet right ventricle (HP:0001719)1.19039468
161Potter facies (HP:0002009)1.18787073
162Facial shape deformation (HP:0011334)1.18787073
163Abnormal urine output (HP:0012590)1.18106096
164Easy fatigability (HP:0003388)1.17557702
165Abnormality of saccadic eye movements (HP:0000570)1.16674789
166Fatigable weakness (HP:0003473)1.15311526
167Abnormality of the neuromuscular junction (HP:0003398)1.15311526
168Absent frontal sinuses (HP:0002688)1.14792725
169Short thorax (HP:0010306)1.14245271
170Degeneration of the lateral corticospinal tracts (HP:0002314)1.12911531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.45922958
2PDK48.45922958
3PDK25.44638760
4TESK15.15023787
5PRKD34.82582741
6ICK3.74810324
7INSRR3.48816242
8ADRBK23.41028021
9TAOK32.96768501
10BMPR1B2.89459641
11FRK2.82297011
12MAP4K22.59504602
13MARK12.44641422
14STK392.29958229
15CASK2.24289296
16ZAK2.16728214
17WNK42.02058965
18TNIK2.01509621
19PTK2B2.01355330
20GRK11.95237964
21WNK31.83889493
22MAPK131.82805702
23ACVR1B1.79336901
24STK381.71291741
25TLK11.69135197
26PHKG21.67460863
27PHKG11.67460863
28PNCK1.63515379
29NEK21.60631877
30DAPK21.58696091
31BCKDK1.57415580
32NUAK11.39530461
33TXK1.38702441
34CSNK1G21.35944394
35TIE11.21499026
36PLK21.19277713
37CSNK1G31.18305962
38PDK11.17933673
39PLK41.17854575
40DYRK1B1.17380183
41STK38L1.12419270
42VRK11.06315862
43TTK1.02221782
44TYRO30.99478855
45PAK30.96459247
46ADRBK10.95158366
47CSNK1G10.95035350
48TGFBR10.93782899
49CSNK1A1L0.91696640
50TSSK60.91420290
51TESK20.89052551
52FES0.87870386
53MKNK20.87373579
54MUSK0.86140578
55CHEK20.86121011
56STK30.85296163
57DYRK1A0.85125819
58CAMKK20.85093542
59IRAK10.84030597
60EEF2K0.81702192
61PRKCE0.78906272
62MAPKAPK30.78031984
63MAPK150.78017589
64BCR0.75774775
65GRK70.73679060
66RPS6KA50.72620366
67DYRK30.72187509
68WNK10.71546052
69BRAF0.70624490
70PDPK10.70134265
71NTRK30.69986103
72MATK0.69586798
73TRIM280.67539903
74KIT0.65330449
75IKBKB0.64635324
76PINK10.63914431
77MAP3K110.59791887
78LATS10.59374738
79NLK0.55983697
80EPHA30.55712489
81MAPKAPK50.52429447
82CHUK0.52309468
83LMTK20.51231905
84CCNB10.50157446
85SYK0.50077971
86BRSK20.49399290
87CDC70.48313878
88CHEK10.47354985
89PRKACA0.47325790
90MAP2K60.47052373
91MAP3K60.44995784
92RIPK40.44179903
93ARAF0.43653742
94CSNK1A10.43019357
95PASK0.42658169
96PAK10.42178928
97IRAK20.41011446
98PRKCA0.40600992
99SIK20.40308554
100NEK60.37191758
101LIMK10.37055688
102LYN0.36262697
103IRAK40.36039803
104ERBB40.35793963
105PRKCI0.35450609
106PAK60.35255991
107STK160.35155828
108NEK90.34984480
109PIK3CA0.34135284
110PLK10.33650799
111ATM0.33644577
112MARK20.32201122
113NME10.31081845
114LATS20.30510198
115NTRK20.30388700
116RPS6KA60.29725867
117LCK0.29482303
118PRKACB0.29341413
119PLK30.28921427
120MAP3K90.28771665
121MAPK120.27973839
122PRKAA10.26908913
123CAMK1G0.26344345
124CAMK10.25890830
125MAP4K10.25563424
126ABL20.25315855
127BRSK10.25041650
128KSR20.24472297
129WEE10.23387750
130ATR0.23300125
131CDK150.22256076
132MOS0.22036042
133PBK0.20356440
134OXSR10.20270612
135STK100.20154339
136DYRK20.19543250
137TAOK10.19337590
138CDK180.18997483
139CDK30.17859850
140PRKCG0.16334515
141CDK11A0.16304284
142MTOR0.16054556
143MARK30.15811804
144PAK20.14787331
145PRKCQ0.14663607
146CDK140.14214926
147MAP2K70.12733505
148CSNK1D0.10621533
149MAP3K40.10367592
150BMPR20.10259869
151PRKCZ0.10091638
152AURKA0.08444458
153CAMK2A0.08072374
154PKN10.08065707
155MAP3K50.08019353
156CDK10.07270262
157CDK120.06742641
158RPS6KB10.06408687
159GSK3B0.06167206
160MAP3K10.05926521
161STK110.04593283
162CAMKK10.04048462
163CDK90.04043263
164CSNK2A10.04015899
165PRKG10.03437720
166CDK20.03353454
167RPS6KA10.02200361
168FGFR20.01532423
169PAK40.01520233
170PRKD20.00709333
171MELK0.00419605

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.70518302
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.36969696
3Fatty acid biosynthesis_Homo sapiens_hsa000614.13985970
4Pyruvate metabolism_Homo sapiens_hsa006203.56338840
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.30468314
6Linoleic acid metabolism_Homo sapiens_hsa005913.22677523
7Basal transcription factors_Homo sapiens_hsa030223.17774297
8Phototransduction_Homo sapiens_hsa047442.93741643
9Propanoate metabolism_Homo sapiens_hsa006402.83326123
10Oxidative phosphorylation_Homo sapiens_hsa001902.70955026
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51131012
12Glucagon signaling pathway_Homo sapiens_hsa049222.49963473
13Nitrogen metabolism_Homo sapiens_hsa009102.46194902
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35091138
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.30601857
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29812035
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21665594
18Nicotine addiction_Homo sapiens_hsa050332.16266809
19Butanoate metabolism_Homo sapiens_hsa006502.15299332
20Oocyte meiosis_Homo sapiens_hsa041142.12267438
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09073867
22Parkinsons disease_Homo sapiens_hsa050122.02418930
23Glycerolipid metabolism_Homo sapiens_hsa005611.93421798
24Pentose phosphate pathway_Homo sapiens_hsa000301.91672918
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91549476
26Ether lipid metabolism_Homo sapiens_hsa005651.82583449
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.81196848
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79612800
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.77465102
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.75818088
31Tryptophan metabolism_Homo sapiens_hsa003801.74426804
32Fanconi anemia pathway_Homo sapiens_hsa034601.73879425
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70232053
34Selenocompound metabolism_Homo sapiens_hsa004501.65512164
35PPAR signaling pathway_Homo sapiens_hsa033201.64291833
36Dorso-ventral axis formation_Homo sapiens_hsa043201.63680494
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63344314
38* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57814977
39Type I diabetes mellitus_Homo sapiens_hsa049401.52630077
40Asthma_Homo sapiens_hsa053101.50789986
41Protein export_Homo sapiens_hsa030601.47179912
42Mineral absorption_Homo sapiens_hsa049781.46334761
43Allograft rejection_Homo sapiens_hsa053301.45059379
44Autoimmune thyroid disease_Homo sapiens_hsa053201.43559629
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.43311069
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43279443
47Alzheimers disease_Homo sapiens_hsa050101.42120651
48Morphine addiction_Homo sapiens_hsa050321.40197818
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36186863
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33270928
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30816046
52RNA polymerase_Homo sapiens_hsa030201.26688333
53Amphetamine addiction_Homo sapiens_hsa050311.26538355
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25757299
55Graft-versus-host disease_Homo sapiens_hsa053321.24082796
56Olfactory transduction_Homo sapiens_hsa047401.23615197
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23058721
58Carbon metabolism_Homo sapiens_hsa012001.20339714
59GABAergic synapse_Homo sapiens_hsa047271.19583039
60Fructose and mannose metabolism_Homo sapiens_hsa000511.18394033
61Purine metabolism_Homo sapiens_hsa002301.18253933
62Fatty acid metabolism_Homo sapiens_hsa012121.15740580
63Rheumatoid arthritis_Homo sapiens_hsa053231.15291315
64Cardiac muscle contraction_Homo sapiens_hsa042601.12611178
65Primary bile acid biosynthesis_Homo sapiens_hsa001201.12225457
66Caffeine metabolism_Homo sapiens_hsa002321.11299481
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08972540
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08072480
69mRNA surveillance pathway_Homo sapiens_hsa030151.07815819
70Huntingtons disease_Homo sapiens_hsa050161.07143456
71Fatty acid degradation_Homo sapiens_hsa000711.06464865
72Regulation of autophagy_Homo sapiens_hsa041401.06449827
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04525910
74Fat digestion and absorption_Homo sapiens_hsa049751.03940438
75Glutathione metabolism_Homo sapiens_hsa004801.03053644
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01371516
77Glutamatergic synapse_Homo sapiens_hsa047240.98669838
78Circadian entrainment_Homo sapiens_hsa047130.98308434
79Sulfur relay system_Homo sapiens_hsa041220.97958129
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97081317
81RNA transport_Homo sapiens_hsa030130.96290867
82Biosynthesis of amino acids_Homo sapiens_hsa012300.93296132
83Collecting duct acid secretion_Homo sapiens_hsa049660.92244500
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90699203
85Peroxisome_Homo sapiens_hsa041460.89501858
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88274134
87Renin secretion_Homo sapiens_hsa049240.88268762
88Arachidonic acid metabolism_Homo sapiens_hsa005900.87523606
89Serotonergic synapse_Homo sapiens_hsa047260.87211028
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86417946
91Hedgehog signaling pathway_Homo sapiens_hsa043400.85106391
92Lysosome_Homo sapiens_hsa041420.84321364
93Cell cycle_Homo sapiens_hsa041100.84087470
94Chemical carcinogenesis_Homo sapiens_hsa052040.79161161
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76863102
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70078592
97Antigen processing and presentation_Homo sapiens_hsa046120.69404286
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66494916
99Estrogen signaling pathway_Homo sapiens_hsa049150.65530159
100Dopaminergic synapse_Homo sapiens_hsa047280.63915362
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63881456
102RNA degradation_Homo sapiens_hsa030180.63481331
103Renin-angiotensin system_Homo sapiens_hsa046140.61371367
104Insulin secretion_Homo sapiens_hsa049110.61059242
105Primary immunodeficiency_Homo sapiens_hsa053400.59774106
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59346424
107Thyroid hormone synthesis_Homo sapiens_hsa049180.57736955
108Ovarian steroidogenesis_Homo sapiens_hsa049130.57251658
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56548502
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55476058
111Long-term potentiation_Homo sapiens_hsa047200.54733146
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.52626304
113Bile secretion_Homo sapiens_hsa049760.51765964
114Endocytosis_Homo sapiens_hsa041440.51176570
115Inositol phosphate metabolism_Homo sapiens_hsa005620.49173399
116VEGF signaling pathway_Homo sapiens_hsa043700.47774999
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.45806178
118beta-Alanine metabolism_Homo sapiens_hsa004100.43981931
119Cholinergic synapse_Homo sapiens_hsa047250.43702299
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.42311331
121Metabolic pathways_Homo sapiens_hsa011000.41699013
122Synaptic vesicle cycle_Homo sapiens_hsa047210.40770705
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40767331
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40669699
125Calcium signaling pathway_Homo sapiens_hsa040200.39378775
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38881194
127Protein digestion and absorption_Homo sapiens_hsa049740.37723949
128Pyrimidine metabolism_Homo sapiens_hsa002400.37545068
129AMPK signaling pathway_Homo sapiens_hsa041520.36459582
130Steroid biosynthesis_Homo sapiens_hsa001000.36444973
131Pancreatic secretion_Homo sapiens_hsa049720.36171738
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33906052
133cAMP signaling pathway_Homo sapiens_hsa040240.32471839
134Homologous recombination_Homo sapiens_hsa034400.32190877
135Oxytocin signaling pathway_Homo sapiens_hsa049210.30635802
136Salivary secretion_Homo sapiens_hsa049700.30632425
137Ribosome_Homo sapiens_hsa030100.28871952
138ABC transporters_Homo sapiens_hsa020100.28097649
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27528683
140Sulfur metabolism_Homo sapiens_hsa009200.27215628
141Phagosome_Homo sapiens_hsa041450.23848423
142Histidine metabolism_Homo sapiens_hsa003400.23555189
143Systemic lupus erythematosus_Homo sapiens_hsa053220.23164932
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22578171
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20383197
146Wnt signaling pathway_Homo sapiens_hsa043100.19003038
147Taste transduction_Homo sapiens_hsa047420.18025036
148Legionellosis_Homo sapiens_hsa051340.17722233
149Gastric acid secretion_Homo sapiens_hsa049710.15998063
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.14595661
151Circadian rhythm_Homo sapiens_hsa047100.11527016
152Sphingolipid metabolism_Homo sapiens_hsa006000.11359828
153Cocaine addiction_Homo sapiens_hsa050300.10214270
154Retinol metabolism_Homo sapiens_hsa008300.09715066
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08922380
156Non-homologous end-joining_Homo sapiens_hsa034500.07969170
157Tight junction_Homo sapiens_hsa045300.07292097

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