DNAJC5G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.74079760
2acrosome reaction (GO:0007340)9.56967382
3acrosome assembly (GO:0001675)9.38790953
4multicellular organism reproduction (GO:0032504)9.23740156
5axonemal dynein complex assembly (GO:0070286)9.21770812
6binding of sperm to zona pellucida (GO:0007339)9.18360454
7cell-cell recognition (GO:0009988)8.71037736
8male meiosis (GO:0007140)8.67309230
9spermatid development (GO:0007286)8.56311633
10cell wall macromolecule metabolic process (GO:0044036)8.50938530
11cell wall macromolecule catabolic process (GO:0016998)8.50938530
12synaptonemal complex organization (GO:0070193)8.49107328
13epithelial cilium movement (GO:0003351)8.48841147
14synaptonemal complex assembly (GO:0007130)8.44636456
15motile cilium assembly (GO:0044458)8.26523189
16plasma membrane fusion (GO:0045026)8.09100564
17reproduction (GO:0000003)7.66509298
18cilium movement (GO:0003341)7.28389961
19regulation of cilium movement (GO:0003352)7.25357112
20DNA methylation involved in gamete generation (GO:0043046)7.07951214
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.04151371
22male meiosis I (GO:0007141)6.47798173
23single fertilization (GO:0007338)6.42205517
24microtubule depolymerization (GO:0007019)6.26424911
25behavioral response to nicotine (GO:0035095)6.10656603
26negative regulation of inclusion body assembly (GO:0090084)6.00177624
27chromosome organization involved in meiosis (GO:0070192)5.97070399
28spermatogenesis (GO:0007283)5.95120262
29male gamete generation (GO:0048232)5.93412678
30fertilization (GO:0009566)5.84852132
31sperm capacitation (GO:0048240)5.76341704
32meiotic nuclear division (GO:0007126)5.71041388
33gamete generation (GO:0007276)5.52509893
34meiosis I (GO:0007127)5.52385386
35germ cell development (GO:0007281)5.16982967
36meiotic cell cycle (GO:0051321)5.06208610
37cellular process involved in reproduction in multicellular organism (GO:0022412)4.97636759
38regulation of inclusion body assembly (GO:0090083)4.92092415
39organic cation transport (GO:0015695)4.72790959
40seminiferous tubule development (GO:0072520)4.65551114
41ventricular system development (GO:0021591)4.47674498
42microtubule severing (GO:0051013)4.46826796
43chromosome condensation (GO:0030261)4.35841324
44multicellular organismal reproductive process (GO:0048609)4.30924978
45DNA packaging (GO:0006323)4.27663869
46regulation of microtubule-based movement (GO:0060632)4.23267927
47regulation of meiosis I (GO:0060631)4.18864771
48meiotic cell cycle process (GO:1903046)4.16905945
49calcium ion-dependent exocytosis (GO:0017156)4.11202183
50gene silencing by RNA (GO:0031047)4.06425868
51cell recognition (GO:0008037)4.00088421
52monoubiquitinated protein deubiquitination (GO:0035520)3.97247456
53chaperone-mediated protein complex assembly (GO:0051131)3.76538451
54regulation of centriole replication (GO:0046599)3.75173398
55regulation of spindle checkpoint (GO:0090231)3.67679262
56left/right pattern formation (GO:0060972)3.60957206
57primary amino compound metabolic process (GO:1901160)3.58707898
58spermatid nucleus differentiation (GO:0007289)3.58606120
59DNA deamination (GO:0045006)3.55402933
60sulfation (GO:0051923)3.55116834
61synapsis (GO:0007129)3.52128393
62response to pheromone (GO:0019236)3.48509696
63fucose catabolic process (GO:0019317)3.45570616
64L-fucose metabolic process (GO:0042354)3.45570616
65L-fucose catabolic process (GO:0042355)3.45570616
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42695803
67multicellular organismal development (GO:0007275)3.38054958
68glycerol ether metabolic process (GO:0006662)3.37914834
69single strand break repair (GO:0000012)3.36294443
70genitalia morphogenesis (GO:0035112)3.36174053
71nuclear pore complex assembly (GO:0051292)3.34422866
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32572472
73microtubule polymerization or depolymerization (GO:0031109)3.30987309
74negative regulation of mast cell activation (GO:0033004)3.29493271
75cytidine deamination (GO:0009972)3.28143147
76cytidine metabolic process (GO:0046087)3.28143147
77cytidine catabolic process (GO:0006216)3.28143147
78protein polyglutamylation (GO:0018095)3.26749526
79ovulation cycle (GO:0042698)3.25662894
80neuron fate determination (GO:0048664)3.25325942
81negative regulation of telomere maintenance (GO:0032205)3.24888485
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.23716764
83ATP synthesis coupled proton transport (GO:0015986)3.23716764
84serotonin metabolic process (GO:0042428)3.22065639
85nucleus organization (GO:0006997)3.21508084
86mitotic sister chromatid cohesion (GO:0007064)3.21393117
87protein localization to cilium (GO:0061512)3.18599493
88protein localization to chromosome, centromeric region (GO:0071459)3.14292879
89histone exchange (GO:0043486)3.13276900
90positive regulation of gastrulation (GO:2000543)3.12623577
91respiratory chain complex IV assembly (GO:0008535)3.11255990
92ether metabolic process (GO:0018904)3.10943567
93cellular ketone body metabolic process (GO:0046950)3.10816468
94neuronal action potential (GO:0019228)3.06688298
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06293730
96DNA methylation (GO:0006306)3.05359343
97DNA alkylation (GO:0006305)3.05359343
98nephron tubule morphogenesis (GO:0072078)3.05140555
99nephron epithelium morphogenesis (GO:0072088)3.05140555
100gene silencing (GO:0016458)3.04448073
101mitochondrial respiratory chain complex assembly (GO:0033108)3.02019903
102reciprocal meiotic recombination (GO:0007131)2.98685138
103reciprocal DNA recombination (GO:0035825)2.98685138
104nuclear pore organization (GO:0006999)2.98173266
105tryptophan catabolic process (GO:0006569)2.97549380
106indole-containing compound catabolic process (GO:0042436)2.97549380
107indolalkylamine catabolic process (GO:0046218)2.97549380
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92316692
109protein complex biogenesis (GO:0070271)2.91375665
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91302931
111protein refolding (GO:0042026)2.91002935
112neuronal action potential propagation (GO:0019227)2.87921266
113nucleoside diphosphate phosphorylation (GO:0006165)2.87804559
114alditol metabolic process (GO:0019400)2.87506646
115negative regulation of leukocyte chemotaxis (GO:0002689)2.87351326
116indolalkylamine metabolic process (GO:0006586)2.87010433
117negative regulation of organelle assembly (GO:1902116)2.86843871
118pyrimidine ribonucleoside catabolic process (GO:0046133)2.86449629
119protein-cofactor linkage (GO:0018065)2.83365514
120detection of light stimulus involved in sensory perception (GO:0050962)2.83280705
121detection of light stimulus involved in visual perception (GO:0050908)2.83280705
122interferon-gamma secretion (GO:0072643)2.81834443
123regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.81190653
124axoneme assembly (GO:0035082)2.79722834
125mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77541802
126mitochondrial respiratory chain complex I assembly (GO:0032981)2.77541802
127NADH dehydrogenase complex assembly (GO:0010257)2.77541802
128microtubule-based movement (GO:0007018)2.77458931
129DNA replication-dependent nucleosome assembly (GO:0006335)2.77448694
130DNA replication-dependent nucleosome organization (GO:0034723)2.77448694
131sister chromatid cohesion (GO:0007062)2.76367883
132regulation of centrosome cycle (GO:0046605)2.72959538
133indole-containing compound metabolic process (GO:0042430)2.72938482
134pyrimidine nucleobase catabolic process (GO:0006208)2.72568622
135meiotic chromosome segregation (GO:0045132)2.72561723
136ketone body metabolic process (GO:1902224)2.72205953
137sequestering of actin monomers (GO:0042989)2.71907124
138centriole replication (GO:0007099)2.71294721
139polyol catabolic process (GO:0046174)2.71211393
140kynurenine metabolic process (GO:0070189)2.68851275
141regulation of rhodopsin mediated signaling pathway (GO:0022400)2.68214588
142atrial cardiac muscle cell action potential (GO:0086014)2.67257470
143intraciliary transport (GO:0042073)2.66751088
144blastocyst development (GO:0001824)2.63635951
145centriole assembly (GO:0098534)2.63379899
146cilium organization (GO:0044782)2.62655345
147amino-acid betaine transport (GO:0015838)2.61820998
148tryptophan metabolic process (GO:0006568)2.61550736
149auditory behavior (GO:0031223)2.58112307
150protein localization to synapse (GO:0035418)2.54871603
151rhodopsin mediated signaling pathway (GO:0016056)2.54870445
152glycerophospholipid catabolic process (GO:0046475)2.54655780
153negative regulation of heart rate (GO:0010459)2.52998816
154endoderm formation (GO:0001706)2.52349766
155cytochrome complex assembly (GO:0017004)2.51365576
156mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50548710
157gamma-aminobutyric acid transport (GO:0015812)2.50055810
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.49073657
159somite development (GO:0061053)2.48806737
160parturition (GO:0007567)2.48159879
161transmission of nerve impulse (GO:0019226)2.46375829
162cerebral cortex radially oriented cell migration (GO:0021799)2.45777107
163establishment of protein localization to mitochondrial membrane (GO:0090151)2.45179418
164spinal cord motor neuron differentiation (GO:0021522)2.45109932
165cAMP catabolic process (GO:0006198)2.44973630
166positive regulation of CREB transcription factor activity (GO:0032793)2.43273939
167nucleobase catabolic process (GO:0046113)2.42450723
168membrane depolarization during action potential (GO:0086010)2.41932193
169protein neddylation (GO:0045116)2.41331625
170retinal cone cell development (GO:0046549)2.40942110
171forebrain neuron differentiation (GO:0021879)2.40829165
172water-soluble vitamin biosynthetic process (GO:0042364)2.39370622
173kidney morphogenesis (GO:0060993)2.38732198
174DNA demethylation (GO:0080111)2.38682242
175action potential (GO:0001508)2.38612463
176cell morphogenesis involved in neuron differentiation (GO:0048667)2.38250642
177platelet dense granule organization (GO:0060155)2.37468730
178auditory receptor cell stereocilium organization (GO:0060088)2.36679988
179pyrimidine dimer repair (GO:0006290)2.35641829
180somite rostral/caudal axis specification (GO:0032525)2.35537323
181regulation of female gonad development (GO:2000194)2.34482189
182histone-serine phosphorylation (GO:0035404)2.34204127
183cilium or flagellum-dependent cell motility (GO:0001539)11.3963625
184sperm motility (GO:0030317)11.2942778
185fusion of sperm to egg plasma membrane (GO:0007342)10.7523187
186piRNA metabolic process (GO:0034587)10.7131067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.10546460
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.81747122
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36259185
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78730821
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.54918496
6GATA1_26923725_Chip-Seq_HPCs_Mouse2.53646678
7GBX2_23144817_ChIP-Seq_PC3_Human2.52704748
8CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.45124350
9KAP1_22055183_ChIP-Seq_ESCs_Mouse2.23828316
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20445151
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14222590
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13781856
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.11725623
14VDR_22108803_ChIP-Seq_LS180_Human2.10148815
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08390942
16IGF1R_20145208_ChIP-Seq_DFB_Human2.07411787
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05276907
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01015889
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00317471
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9741911
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99525225
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87342871
23TAF15_26573619_Chip-Seq_HEK293_Human1.86331903
24FUS_26573619_Chip-Seq_HEK293_Human1.82622246
25EWS_26573619_Chip-Seq_HEK293_Human1.81309884
26IRF1_19129219_ChIP-ChIP_H3396_Human1.80952489
27P300_19829295_ChIP-Seq_ESCs_Human1.79847108
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75859929
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.74471512
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70165804
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68905361
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68304181
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67500494
34KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66388388
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65580753
36STAT1_17558387_ChIP-Seq_HELA_Human1.64973946
37ER_23166858_ChIP-Seq_MCF-7_Human1.64299411
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.63522532
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.62753609
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62638982
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57570499
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56673489
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55703680
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54577426
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53746626
46ZNF274_21170338_ChIP-Seq_K562_Hela1.53184146
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.53160297
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50089015
49* TP53_22573176_ChIP-Seq_HFKS_Human1.49685739
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.48922908
51BCAT_22108803_ChIP-Seq_LS180_Human1.47131599
52* GATA3_21878914_ChIP-Seq_MCF-7_Human1.46447148
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44027332
54MYC_18940864_ChIP-ChIP_HL60_Human1.43579821
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.42300814
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41762733
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40244127
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38351726
59GATA3_21867929_ChIP-Seq_TH1_Mouse1.38282686
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36989279
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35721107
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33740963
63AR_25329375_ChIP-Seq_VCAP_Human1.31466459
64TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.31254815
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30482462
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29305764
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29017742
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.28199851
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27273281
70SMAD4_21799915_ChIP-Seq_A2780_Human1.26299035
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.25512385
72STAT3_23295773_ChIP-Seq_U87_Human1.25274067
73FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25060210
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24790280
75RUNX1_26923725_Chip-Seq_HPCs_Mouse1.24678296
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24318194
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24113645
78NANOG_19829295_ChIP-Seq_ESCs_Human1.23823121
79SOX2_19829295_ChIP-Seq_ESCs_Human1.23823121
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.23058084
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22816816
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21600879
83MYC_19829295_ChIP-Seq_ESCs_Human1.20830807
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20813720
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19803626
86GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.19644290
87HOXB7_26014856_ChIP-Seq_BT474_Human1.19243743
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.18157199
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17517136
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17085162
91TCF4_23295773_ChIP-Seq_U87_Human1.16197513
92NCOR_22424771_ChIP-Seq_293T_Human1.16151717
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.16126504
94TCF4_22108803_ChIP-Seq_LS180_Human1.15390657
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.13005409
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12566755
97RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12516509
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12516509
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.12380562
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12380562
101RUNX2_22187159_ChIP-Seq_PCA_Human1.12238101
102ERA_21632823_ChIP-Seq_H3396_Human1.12073358
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11496530
104KDM2B_26808549_Chip-Seq_REH_Human1.11403980
105P53_21459846_ChIP-Seq_SAOS-2_Human1.11379108
106SPI1_26923725_Chip-Seq_HPCs_Mouse1.10726246
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10093830
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.10046070
109CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09174160
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08747655
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08001263
112GF1_26923725_Chip-Seq_HPCs_Mouse1.07673963
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07074656
114SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06959857
115LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06776776
116HTT_18923047_ChIP-ChIP_STHdh_Human1.06593180
117YY1_22570637_ChIP-Seq_MALME-3M_Human1.05262032
118* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04644616
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04489303
120AR_21909140_ChIP-Seq_LNCAP_Human1.04379566
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.03933866
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.03665952
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03653264
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03367488
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03259971
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03197768
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.02822967
128CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02703118
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.01942379
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01931405
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01244492
132ERG_20517297_ChIP-Seq_VCAP_Human0.99921863
133* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99326931
134FLI1_21867929_ChIP-Seq_CD8_Mouse0.99064085
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.98885843
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98678678
137CBP_20019798_ChIP-Seq_JUKART_Human0.98678678
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98524242
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98524242
140POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98227808
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.98110245
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97807506
143PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97685017
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97307520
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.97215695
146KLF4_18555785_Chip-Seq_ESCs_Mouse0.96467635
147EZH2_27294783_Chip-Seq_NPCs_Mouse0.96293915
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96186130
149E2F7_22180533_ChIP-Seq_HELA_Human0.96134389
150LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95721774
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.95388452
152EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95003213
153RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94468850
154NFYB_21822215_ChIP-Seq_K562_Human0.93045642
155SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92598359
156RNF2_27304074_Chip-Seq_NSC_Mouse0.92397652
157ESRRB_18555785_Chip-Seq_ESCs_Mouse0.92001289
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91584534
159RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91318602
160MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89606779
161ETV1_20927104_ChIP-Seq_GIST48_Human0.88595287
162REST_21632747_ChIP-Seq_MESCs_Mouse0.87885534
163STAT3_18555785_Chip-Seq_ESCs_Mouse0.87600991
164TBL1_22424771_ChIP-Seq_293T_Human0.87454606
165EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86995642
166E2F4_17652178_ChIP-ChIP_JURKAT_Human0.86651792
167RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85757749
168P53_22387025_ChIP-Seq_ESCs_Mouse0.85253311
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84955704
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84697597
171P300_18555785_Chip-Seq_ESCs_Mouse0.84651962
172NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84561459
173STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84311119
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.83540635
175SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82517185
176NANOG_20526341_ChIP-Seq_ESCs_Human0.82071344
177CBX2_27304074_Chip-Seq_ESCs_Mouse0.81215541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.87158352
2MP0003698_abnormal_male_reproductive5.61197553
3MP0001929_abnormal_gametogenesis5.56707723
4MP0006292_abnormal_olfactory_placode4.10398874
5MP0002210_abnormal_sex_determination4.09624066
6MP0001145_abnormal_male_reproductive3.39820937
7MP0002161_abnormal_fertility/fecundity3.24256033
8MP0000653_abnormal_sex_gland3.06113121
9MP0002653_abnormal_ependyma_morphology2.98431514
10MP0003880_abnormal_central_pattern2.46526808
11MP0004147_increased_porphyrin_level2.43787525
12MP0010094_abnormal_chromosome_stability2.41417050
13MP0005551_abnormal_eye_electrophysiolog2.34569237
14MP0008058_abnormal_DNA_repair2.31857508
15MP0003693_abnormal_embryo_hatching2.26717503
16MP0006276_abnormal_autonomic_nervous2.26353053
17MP0005423_abnormal_somatic_nervous2.23951990
18MP0001968_abnormal_touch/_nociception2.17606542
19MP0003111_abnormal_nucleus_morphology2.10358343
20MP0009745_abnormal_behavioral_response2.07049668
21MP0004133_heterotaxia2.05939067
22MP0008875_abnormal_xenobiotic_pharmacok2.00397113
23MP0005410_abnormal_fertilization13.3251054
24MP0002160_abnormal_reproductive_system1.96156856
25MP0008057_abnormal_DNA_replication1.92958166
26MP0005646_abnormal_pituitary_gland1.90197507
27MP0002876_abnormal_thyroid_physiology1.86155720
28MP0000631_abnormal_neuroendocrine_gland1.84926788
29MP0003195_calcinosis1.84601199
30MP0008995_early_reproductive_senescence1.84294835
31MP0005167_abnormal_blood-brain_barrier1.84071894
32MP0002272_abnormal_nervous_system1.82811423
33MP0001485_abnormal_pinna_reflex1.78441350
34MP0003786_premature_aging1.74634272
35MP0003646_muscle_fatigue1.73821981
36MP0002138_abnormal_hepatobiliary_system1.73605063
37MP0005670_abnormal_white_adipose1.73091240
38MP0002735_abnormal_chemical_nociception1.73078764
39MP0002102_abnormal_ear_morphology1.71189168
40MP0002736_abnormal_nociception_after1.67358301
41MP0004885_abnormal_endolymph1.66448725
42MP0002277_abnormal_respiratory_mucosa1.56763839
43MP0002572_abnormal_emotion/affect_behav1.50740021
44MP0006072_abnormal_retinal_apoptosis1.48876428
45MP0003077_abnormal_cell_cycle1.47007751
46MP0002064_seizures1.45956000
47MP0005253_abnormal_eye_physiology1.45690791
48MP0003718_maternal_effect1.45028179
49MP0004742_abnormal_vestibular_system1.44869245
50MP0004142_abnormal_muscle_tone1.44821444
51MP0005623_abnormal_meninges_morphology1.42632200
52MP0003890_abnormal_embryonic-extraembry1.42003935
53MP0001501_abnormal_sleep_pattern1.41658408
54MP0008775_abnormal_heart_ventricle1.39237634
55MP0001486_abnormal_startle_reflex1.38983940
56MP0005085_abnormal_gallbladder_physiolo1.36206331
57MP0004145_abnormal_muscle_electrophysio1.35328051
58MP0010030_abnormal_orbit_morphology1.35319992
59MP0008872_abnormal_physiological_respon1.34929920
60MP0002733_abnormal_thermal_nociception1.31478412
61MP0004957_abnormal_blastocyst_morpholog1.31251406
62MP0002837_dystrophic_cardiac_calcinosis1.27328607
63MP0002063_abnormal_learning/memory/cond1.26404148
64MP0005645_abnormal_hypothalamus_physiol1.25636226
65MP0000026_abnormal_inner_ear1.25492718
66MP0008789_abnormal_olfactory_epithelium1.22730998
67MP0001970_abnormal_pain_threshold1.22502481
68MP0002638_abnormal_pupillary_reflex1.21407060
69MP0005084_abnormal_gallbladder_morpholo1.19350350
70MP0005389_reproductive_system_phenotype1.19119929
71MP0008007_abnormal_cellular_replicative1.18218832
72MP0002938_white_spotting1.16401570
73MP0002734_abnormal_mechanical_nocicepti1.15768144
74MP0003635_abnormal_synaptic_transmissio1.14377156
75MP0009379_abnormal_foot_pigmentation1.12569826
76MP0002557_abnormal_social/conspecific_i1.11764358
77MP0005187_abnormal_penis_morphology1.10041573
78MP0002067_abnormal_sensory_capabilities1.08798650
79MP0005647_abnormal_sex_gland1.06624734
80MP0005451_abnormal_body_composition1.04624744
81MP0004215_abnormal_myocardial_fiber1.03724291
82MP0002282_abnormal_trachea_morphology1.03468476
83MP0000049_abnormal_middle_ear1.02908788
84MP0003878_abnormal_ear_physiology1.02295912
85MP0005377_hearing/vestibular/ear_phenot1.02295912
86MP0001905_abnormal_dopamine_level1.00478846
87MP0000383_abnormal_hair_follicle0.99627167
88MP0003699_abnormal_female_reproductive0.99491351
89MP0003137_abnormal_impulse_conducting0.98449879
90MP0001119_abnormal_female_reproductive0.96116016
91MP0005195_abnormal_posterior_eye0.94694287
92MP0001963_abnormal_hearing_physiology0.94203440
93MP0004043_abnormal_pH_regulation0.91758747
94MP0003122_maternal_imprinting0.91028004
95MP0001730_embryonic_growth_arrest0.90888348
96MP0008932_abnormal_embryonic_tissue0.90786922
97MP0005499_abnormal_olfactory_system0.90094556
98MP0005394_taste/olfaction_phenotype0.90094556
99MP0003937_abnormal_limbs/digits/tail_de0.89275700
100MP0003123_paternal_imprinting0.86708205
101MP0002752_abnormal_somatic_nervous0.85699073
102MP0002234_abnormal_pharynx_morphology0.83881769
103MP0003567_abnormal_fetal_cardiomyocyte0.83237362
104MP0001502_abnormal_circadian_rhythm0.82880101
105MP0003938_abnormal_ear_development0.82714831
106MP0002095_abnormal_skin_pigmentation0.81856231
107MP0004085_abnormal_heartbeat0.81727914
108MP0010386_abnormal_urinary_bladder0.81666890
109MP0004233_abnormal_muscle_weight0.77818382
110MP0010307_abnormal_tumor_latency0.77204500
111MP0005380_embryogenesis_phenotype0.70995523
112MP0001672_abnormal_embryogenesis/_devel0.70995523
113MP0004808_abnormal_hematopoietic_stem0.69670582
114MP0001765_abnormal_ion_homeostasis0.69528121
115MP0005395_other_phenotype0.65914915
116MP0001545_abnormal_hematopoietic_system0.64396859
117MP0005397_hematopoietic_system_phenotyp0.64396859
118MP0003011_delayed_dark_adaptation0.62409349
119MP0000358_abnormal_cell_content/0.60203382
120MP0003136_yellow_coat_color0.58932585
121MP0001293_anophthalmia0.58161821
122MP0001727_abnormal_embryo_implantation0.58034503
123MP0000313_abnormal_cell_death0.57784471
124MP0004019_abnormal_vitamin_homeostasis0.57520114
125MP0001986_abnormal_taste_sensitivity0.56533341
126MP0002084_abnormal_developmental_patter0.54088767
127MP0001697_abnormal_embryo_size0.54076271
128MP0000350_abnormal_cell_proliferation0.52038558
129MP0003984_embryonic_growth_retardation0.51736966
130MP0009046_muscle_twitch0.51365557
131MP0003315_abnormal_perineum_morphology0.51079328
132MP0009672_abnormal_birth_weight0.50928574
133MP0002085_abnormal_embryonic_tissue0.50390805
134MP0000569_abnormal_digit_pigmentation0.48983103
135MP0002088_abnormal_embryonic_growth/wei0.48220893
136MP0004036_abnormal_muscle_relaxation0.47310128
137MP0008260_abnormal_autophagy0.45995202
138MP0003950_abnormal_plasma_membrane0.45977071
139MP0002080_prenatal_lethality0.45010411
140MP0001984_abnormal_olfaction0.44880606
141MP0003115_abnormal_respiratory_system0.44177932
142MP0003936_abnormal_reproductive_system0.42899766
143MP0009278_abnormal_bone_marrow0.42067246
144MP0001661_extended_life_span0.40278073
145MP0002796_impaired_skin_barrier0.40210333
146MP0000579_abnormal_nail_morphology0.38868655
147MP0001919_abnormal_reproductive_system0.37761343
148MP0005666_abnormal_adipose_tissue0.36515913
149MP0001764_abnormal_homeostasis0.35447309
150MP0000427_abnormal_hair_cycle0.34977490
151MP0002269_muscular_atrophy0.34126373
152MP0004197_abnormal_fetal_growth/weight/0.33330476
153MP0003861_abnormal_nervous_system0.31387357
154MP0005636_abnormal_mineral_homeostasis0.31180265
155MP0002092_abnormal_eye_morphology0.30602225
156MP0000462_abnormal_digestive_system0.30213182
157MP0005391_vision/eye_phenotype0.30211633
158MP0000490_abnormal_crypts_of0.29390905
159MP0001324_abnormal_eye_pigmentation0.28706710
160MP0003787_abnormal_imprinting0.27648130
161MP0003119_abnormal_digestive_system0.26595203
162MP0002873_normal_phenotype0.26231788
163MP0002169_no_abnormal_phenotype0.26200315
164MP0000647_abnormal_sebaceous_gland0.25772438
165MP0004264_abnormal_extraembryonic_tissu0.25673006
166MP0002086_abnormal_extraembryonic_tissu0.25272755
167MP0002019_abnormal_tumor_incidence0.25123884
168MP0003879_abnormal_hair_cell0.24423931
169MP0009703_decreased_birth_body0.24147303
170MP0003121_genomic_imprinting0.22403870
171MP0000566_synostosis0.22322018

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.92529952
2Abnormal respiratory epithelium morphology (HP:0012253)8.44393619
3Abnormal respiratory motile cilium morphology (HP:0005938)8.44393619
4Rhinitis (HP:0012384)7.55578734
5Chronic bronchitis (HP:0004469)6.97525101
6Abnormal ciliary motility (HP:0012262)6.94439427
7Infertility (HP:0000789)6.65844346
8Nasal polyposis (HP:0100582)5.84025244
9Abnormality of the nasal mucosa (HP:0000433)4.68828671
10Male infertility (HP:0003251)4.54737464
11Bronchiectasis (HP:0002110)4.41708623
12Pancreatic cysts (HP:0001737)4.29482998
13Bronchitis (HP:0012387)4.23600872
14Nephronophthisis (HP:0000090)4.19467000
15Abnormal spermatogenesis (HP:0008669)4.15044024
16Impulsivity (HP:0100710)3.75963841
17Congenital stationary night blindness (HP:0007642)3.73344703
18True hermaphroditism (HP:0010459)3.64870791
19Chronic hepatic failure (HP:0100626)3.47186380
20Azoospermia (HP:0000027)3.22282293
21Abnormality of the renal medulla (HP:0100957)3.19967932
22Recurrent otitis media (HP:0000403)3.09285465
23Gonadotropin excess (HP:0000837)3.03022679
24Recurrent sinusitis (HP:0011108)2.94480988
25Abnormality of the lower motor neuron (HP:0002366)2.89611358
26Type II lissencephaly (HP:0007260)2.88298784
27Pendular nystagmus (HP:0012043)2.84659540
28Cerebellar dysplasia (HP:0007033)2.76301052
29Hypoplasia of the uterus (HP:0000013)2.74706180
30Hypoplasia of the capital femoral epiphysis (HP:0003090)2.74352519
31Delayed CNS myelination (HP:0002188)2.71209033
32Birth length less than 3rd percentile (HP:0003561)2.69375514
33Attenuation of retinal blood vessels (HP:0007843)2.67982195
34Abnormality of alanine metabolism (HP:0010916)2.67561424
35Hyperalaninemia (HP:0003348)2.67561424
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67561424
37Congenital, generalized hypertrichosis (HP:0004540)2.63048320
38Aplasia/hypoplasia of the uterus (HP:0008684)2.55632189
39Sclerocornea (HP:0000647)2.54229263
40Broad-based gait (HP:0002136)2.53554639
41Tubulointerstitial nephritis (HP:0001970)2.52889927
42Molar tooth sign on MRI (HP:0002419)2.49907188
43Abnormality of midbrain morphology (HP:0002418)2.49907188
44Hyperventilation (HP:0002883)2.45256171
45Polyuria (HP:0000103)2.45239062
46Abnormality of the labia minora (HP:0012880)2.44010506
47Recurrent bronchitis (HP:0002837)2.40984719
48Abolished electroretinogram (ERG) (HP:0000550)2.35437526
49Amyotrophic lateral sclerosis (HP:0007354)2.34349573
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.31738887
51Increased corneal curvature (HP:0100692)2.30826621
52Keratoconus (HP:0000563)2.30826621
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.28063558
54Concave nail (HP:0001598)2.26210308
55Tubular atrophy (HP:0000092)2.24362768
56Spastic tetraparesis (HP:0001285)2.24200242
57Anencephaly (HP:0002323)2.23132061
58Mitochondrial inheritance (HP:0001427)2.20988944
59Chorioretinal atrophy (HP:0000533)2.20359544
60Male pseudohermaphroditism (HP:0000037)2.20174139
61Aplasia/Hypoplasia of the patella (HP:0006498)2.19782305
62Retinal dysplasia (HP:0007973)2.19764252
63Patellar aplasia (HP:0006443)2.18611652
64Abnormal number of erythroid precursors (HP:0012131)2.15517310
65Lipid accumulation in hepatocytes (HP:0006561)2.14348430
66Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13093211
67Absent epiphyses (HP:0010577)2.13093211
68Optic nerve hypoplasia (HP:0000609)2.12675397
69Lissencephaly (HP:0001339)2.12455990
70Tubulointerstitial abnormality (HP:0001969)2.11722924
71Hypomagnesemia (HP:0002917)2.11611921
72Short tibia (HP:0005736)2.11530600
73Abnormal rod and cone electroretinograms (HP:0008323)2.11308520
74Inability to walk (HP:0002540)2.09903663
75Abnormality of the middle phalanges of the toes (HP:0010183)2.09290890
76Occipital encephalocele (HP:0002085)2.09112025
77Increased hepatocellular lipid droplets (HP:0006565)2.08090001
78Oligodactyly (hands) (HP:0001180)2.07100892
79Hypothermia (HP:0002045)2.05910141
80Medial flaring of the eyebrow (HP:0010747)2.05583937
81Supernumerary spleens (HP:0009799)2.04597075
82Degeneration of anterior horn cells (HP:0002398)2.03380727
83Abnormality of the anterior horn cell (HP:0006802)2.03380727
84Fibular hypoplasia (HP:0003038)2.02696363
85Myokymia (HP:0002411)2.01669427
86Increased CSF lactate (HP:0002490)2.01185069
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01134508
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9245068
89Absent/shortened dynein arms (HP:0200106)11.9347540
90Dynein arm defect of respiratory motile cilia (HP:0012255)11.9347540
91Anterior segment dysgenesis (HP:0007700)1.98705542
92Postaxial foot polydactyly (HP:0001830)1.98266905
93Fair hair (HP:0002286)1.98231535
94Abnormal urine output (HP:0012590)1.97129938
95Facial cleft (HP:0002006)1.96829806
96Abnormality of cells of the erythroid lineage (HP:0012130)1.92981235
97Abnormality of the aortic arch (HP:0012303)1.92398905
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.90904153
99Septo-optic dysplasia (HP:0100842)1.90122417
100Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88939893
101Atonic seizures (HP:0010819)1.88228534
1023-Methylglutaconic aciduria (HP:0003535)1.86063840
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85718845
104Thyroid-stimulating hormone excess (HP:0002925)1.85530274
105Congenital hepatic fibrosis (HP:0002612)1.80922514
106Hemiparesis (HP:0001269)1.80041101
107Furrowed tongue (HP:0000221)1.78698653
108Anophthalmia (HP:0000528)1.77657412
109Gait imbalance (HP:0002141)1.77551468
110Chronic sinusitis (HP:0011109)1.76902838
111Optic disc pallor (HP:0000543)1.76624654
112Renal Fanconi syndrome (HP:0001994)1.76553780
113Protruding tongue (HP:0010808)1.75581403
114Short ribs (HP:0000773)1.73521661
115Heterotopia (HP:0002282)1.73060165
116Abnormality of the renal cortex (HP:0011035)1.72224960
117Impaired proprioception (HP:0010831)1.71046839
118Congenital primary aphakia (HP:0007707)1.69860046
119Preaxial hand polydactyly (HP:0001177)1.69376278
120Stage 5 chronic kidney disease (HP:0003774)1.68781983
121Renal dysplasia (HP:0000110)1.68623154
122Pachygyria (HP:0001302)1.67588632
123Nephrogenic diabetes insipidus (HP:0009806)1.66807824
124Tubulointerstitial fibrosis (HP:0005576)1.66314988
125Progressive cerebellar ataxia (HP:0002073)1.66124249
126Acute necrotizing encephalopathy (HP:0006965)1.65515172
127Double outlet right ventricle (HP:0001719)1.65466148
128Congenital malformation of the right heart (HP:0011723)1.65466148
129Upper motor neuron abnormality (HP:0002127)1.61452351
130Oculomotor apraxia (HP:0000657)1.61154988
131Microglossia (HP:0000171)1.59529737
132Abnormality of the dental root (HP:0006486)1.55816312
133Taurodontia (HP:0000679)1.55816312
134Abnormality of permanent molar morphology (HP:0011071)1.55816312
135Median cleft lip (HP:0000161)1.53560765
136Deformed sella turcica (HP:0002681)1.52998906
137Sloping forehead (HP:0000340)1.50827570
138Pancreatic fibrosis (HP:0100732)1.48795488
139Breast carcinoma (HP:0003002)1.46667659
140Bundle branch block (HP:0011710)1.45547364
141Abnormality of molar (HP:0011077)1.44965399
142Abnormality of molar morphology (HP:0011070)1.44965399
143Abnormal gallbladder physiology (HP:0012438)1.44262934
144Cholecystitis (HP:0001082)1.44262934
145Postaxial hand polydactyly (HP:0001162)1.42810137
146Dyschromatopsia (HP:0007641)1.42656924
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.42346545
148J-shaped sella turcica (HP:0002680)1.42338897
149Abnormality of the dental pulp (HP:0006479)1.41532872
150Broad distal phalanx of finger (HP:0009836)1.40662889
151Bell-shaped thorax (HP:0001591)1.40283873
152Chromosomal breakage induced by crosslinking agents (HP:0003221)1.38698107
153Bile duct proliferation (HP:0001408)1.37606378
154Abnormal biliary tract physiology (HP:0012439)1.37606378
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.37316645
156Chromsome breakage (HP:0040012)1.36953619
157Polydipsia (HP:0001959)1.36763365
158Abnormal drinking behavior (HP:0030082)1.36763365
159Meckel diverticulum (HP:0002245)1.36573149
160Decreased central vision (HP:0007663)1.36059829
161Short thorax (HP:0010306)1.34638585
162Abnormality of the preputium (HP:0100587)1.33391480
163Abnormality of chromosome stability (HP:0003220)1.32438059
164Selective tooth agenesis (HP:0001592)1.30828941
165Abnormality of renal excretion (HP:0011036)1.29231115
166Abnormality of the ileum (HP:0001549)1.28784423
167Glucose intolerance (HP:0000833)1.28399108
168Personality changes (HP:0000751)1.28352046
169Nephroblastoma (Wilms tumor) (HP:0002667)1.27538015
170Short nail (HP:0001799)1.27342793
171Cleft eyelid (HP:0000625)1.26938164
172Ectopic kidney (HP:0000086)1.25251144
173Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23442426
174Cystic liver disease (HP:0006706)1.22799594
175Abnormality of dentin (HP:0010299)1.21568972
176Abnormal connection of the cardiac segments (HP:0011545)1.21358699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.01519802
2PDK38.01519802
3PDK25.23460775
4TESK14.54800753
5INSRR4.21593884
6PRKD34.14879454
7ICK3.29451926
8TLK13.19677821
9PNCK3.09746686
10CDK192.94893547
11MAP4K22.79030297
12CASK2.67473538
13NEK22.59003009
14GRK12.47222616
15ADRBK22.40450447
16WEE12.12412525
17FRK2.08484512
18NUAK11.95249543
19MAP3K41.82438982
20WNK41.79421908
21STK391.78604620
22MARK11.76068355
23TTK1.74376537
24DAPK21.74337368
25PTK2B1.73693219
26VRK21.70888613
27STK381.64327859
28TIE11.58554240
29PLK41.57327222
30PLK21.57216588
31TNIK1.51632302
32BUB11.48932040
33VRK11.42946046
34CDC71.40702566
35MAPK131.34078101
36NTRK31.33075135
37TXK1.31571931
38STK31.27887586
39TAOK31.22908082
40DYRK31.18990999
41EPHB21.10832888
42CHEK21.10400252
43OXSR11.08020705
44CCNB11.06529329
45BRSK21.05264892
46DYRK21.03078944
47PLK11.02903034
48FLT31.01959790
49STK38L0.99611624
50PINK10.97549466
51DYRK1B0.93977024
52TGFBR10.90603093
53TYRO30.87138883
54CHEK10.83585456
55PDK10.79919262
56PASK0.79861774
57MAPK150.78211338
58MUSK0.77636795
59CAMKK20.76313627
60EEF2K0.76170175
61MAP2K70.70451379
62ATR0.68925235
63ADRBK10.68501998
64PIK3CA0.68352209
65BRAF0.68169509
66CSNK1G20.68028634
67NTRK20.67221339
68RPS6KA50.66803642
69WNK10.66406109
70BRSK10.63848013
71CAMK2A0.61651546
72PRKCE0.61629491
73ATM0.61161034
74GRK70.60523149
75ACVR1B0.60404927
76CAMK10.59944022
77MAP3K90.58434884
78IRAK10.57696857
79CAMK1D0.55072644
80SRPK10.54887523
81PHKG10.52879251
82PHKG20.52879251
83PRKCQ0.51800287
84PRKCI0.51063504
85TNK20.50626725
86CSNK1G10.49206335
87KDR0.48999186
88EIF2AK10.48083948
89STK160.46913707
90PLK30.46885250
91MKNK20.46465891
92CSNK1G30.46332201
93PAK30.44178923
94CDK120.44099754
95PRKACA0.43963034
96RPS6KA60.43526495
97AURKB0.43293534
98PRKCH0.43182648
99PTK60.42325603
100LATS20.42117473
101IKBKB0.42087078
102PAK10.41188771
103TESK20.38790641
104CAMK40.37373903
105MAP2K60.37139971
106LATS10.36669656
107AKT30.35668869
108PRKAA20.35665789
109STK110.35536368
110AURKA0.35150121
111PDPK10.35140922
112PRKAA10.34636759
113PRKG10.34554742
114MTOR0.34371210
115WNK30.34215069
116IRAK20.32303491
117CHUK0.31496921
118NEK90.30663251
119MAPKAPK50.29811062
120PKN20.29805071
121ITK0.28260163
122SIK20.28234215
123KIT0.28146506
124BMPR1B0.27793426
125NEK60.27434809
126EPHA40.27407021
127CDK10.26817605
128CDK70.26812573
129CDK20.26750806
130PRKCA0.26341865
131PKN10.25581997
132SGK10.25483074
133TRIM280.25092438
134CSNK1A1L0.24784212
135TAOK10.24673847
136CAMK1G0.24167224
137PRKCG0.23799718
138PIM10.23300057
139TSSK60.21419068
140STK100.20177127
141CSNK2A10.19834181
142CDK40.19036343
143STK40.18767273
144CDK30.17490895
145OBSCN0.16705819
146PAK60.16366552
147RPS6KA40.16075564
148MAPKAPK30.15637740
149NEK10.14673664
150CSNK1E0.14246470
151MAP3K80.14195324
152EIF2AK20.12785114
153CSNK2A20.12661376
154LMTK20.11803682
155GSK3B0.11545480
156MARK30.10720674
157PAK20.10495792
158RPS6KB10.10144421
159CSNK1D0.10061975
160CAMKK10.09072328
161RIPK40.08418517
162ZAK0.07498986
163MARK20.05894691
164RPS6KA10.05706671
165PRKACB0.05014588
166PRKDC0.04780269
167PRKCZ0.04271330
168MAP3K50.02939574

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.95805016
2Basal transcription factors_Homo sapiens_hsa030223.76083095
3Phototransduction_Homo sapiens_hsa047443.10667591
4Fatty acid biosynthesis_Homo sapiens_hsa000613.07572717
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.04947759
6Linoleic acid metabolism_Homo sapiens_hsa005912.98287136
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98225485
8Fanconi anemia pathway_Homo sapiens_hsa034602.92384808
9Oxidative phosphorylation_Homo sapiens_hsa001902.80262979
10Nitrogen metabolism_Homo sapiens_hsa009102.66699833
11RNA transport_Homo sapiens_hsa030132.66391317
12Pyruvate metabolism_Homo sapiens_hsa006202.65721146
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60933768
14Nicotine addiction_Homo sapiens_hsa050332.60906624
15Parkinsons disease_Homo sapiens_hsa050122.45308790
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28293395
17Oocyte meiosis_Homo sapiens_hsa041142.23216250
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18666027
19Dorso-ventral axis formation_Homo sapiens_hsa043202.14210802
20Selenocompound metabolism_Homo sapiens_hsa004502.12256363
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11127063
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07549475
23Pentose phosphate pathway_Homo sapiens_hsa000302.05789881
24Glucagon signaling pathway_Homo sapiens_hsa049221.99862495
25Homologous recombination_Homo sapiens_hsa034401.99836016
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.98321766
27Propanoate metabolism_Homo sapiens_hsa006401.90320450
28Ribosome_Homo sapiens_hsa030101.80043669
29Cell cycle_Homo sapiens_hsa041101.79209192
30mRNA surveillance pathway_Homo sapiens_hsa030151.79053542
31Glycerolipid metabolism_Homo sapiens_hsa005611.71492338
32Caffeine metabolism_Homo sapiens_hsa002321.71181173
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69786401
34Butanoate metabolism_Homo sapiens_hsa006501.69385872
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.64946116
36DNA replication_Homo sapiens_hsa030301.59734402
37Purine metabolism_Homo sapiens_hsa002301.57240236
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50748161
39Olfactory transduction_Homo sapiens_hsa047401.48856635
40Alzheimers disease_Homo sapiens_hsa050101.47381553
41Morphine addiction_Homo sapiens_hsa050321.46984157
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46871585
43Fructose and mannose metabolism_Homo sapiens_hsa000511.46774446
44Protein export_Homo sapiens_hsa030601.45559203
45Ether lipid metabolism_Homo sapiens_hsa005651.42944369
46Pyrimidine metabolism_Homo sapiens_hsa002401.42668750
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42375897
48Mismatch repair_Homo sapiens_hsa034301.37345808
49Proteasome_Homo sapiens_hsa030501.34055295
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30560862
51Base excision repair_Homo sapiens_hsa034101.28913301
52GABAergic synapse_Homo sapiens_hsa047271.23433027
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22344902
54Antigen processing and presentation_Homo sapiens_hsa046121.22317450
55* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20274327
56Nucleotide excision repair_Homo sapiens_hsa034201.18296565
57Huntingtons disease_Homo sapiens_hsa050161.17835267
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.17490795
59RNA degradation_Homo sapiens_hsa030181.17490369
60Tryptophan metabolism_Homo sapiens_hsa003801.16975589
61PPAR signaling pathway_Homo sapiens_hsa033201.16446585
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15388330
63Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14476898
64Glutamatergic synapse_Homo sapiens_hsa047241.14236462
65Fat digestion and absorption_Homo sapiens_hsa049751.12335626
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10007292
67Ovarian steroidogenesis_Homo sapiens_hsa049131.07183409
68RNA polymerase_Homo sapiens_hsa030201.06263910
69Circadian entrainment_Homo sapiens_hsa047131.04967680
70Non-homologous end-joining_Homo sapiens_hsa034501.04875936
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04629645
72Serotonergic synapse_Homo sapiens_hsa047261.02603345
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02364360
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01746072
75Primary immunodeficiency_Homo sapiens_hsa053400.99556104
76Arachidonic acid metabolism_Homo sapiens_hsa005900.99177936
77One carbon pool by folate_Homo sapiens_hsa006700.98303149
78Amphetamine addiction_Homo sapiens_hsa050310.94149966
79Spliceosome_Homo sapiens_hsa030400.93794399
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.93684185
81Peroxisome_Homo sapiens_hsa041460.92849115
82Calcium signaling pathway_Homo sapiens_hsa040200.91856815
83Carbon metabolism_Homo sapiens_hsa012000.91808653
84Mineral absorption_Homo sapiens_hsa049780.88755004
85Biosynthesis of amino acids_Homo sapiens_hsa012300.87007313
86beta-Alanine metabolism_Homo sapiens_hsa004100.84228382
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82951625
88Insulin secretion_Homo sapiens_hsa049110.82854230
89p53 signaling pathway_Homo sapiens_hsa041150.81382038
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80496922
91Salivary secretion_Homo sapiens_hsa049700.79663501
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.79660432
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.79176392
94Hedgehog signaling pathway_Homo sapiens_hsa043400.75731280
95Asthma_Homo sapiens_hsa053100.74213066
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72512122
97Fatty acid metabolism_Homo sapiens_hsa012120.71341473
98Glutathione metabolism_Homo sapiens_hsa004800.71164408
99Epstein-Barr virus infection_Homo sapiens_hsa051690.69714883
100Cocaine addiction_Homo sapiens_hsa050300.69256126
101Collecting duct acid secretion_Homo sapiens_hsa049660.68326159
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65375202
103Basal cell carcinoma_Homo sapiens_hsa052170.62118985
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59779845
105Bile secretion_Homo sapiens_hsa049760.58976973
106Vitamin digestion and absorption_Homo sapiens_hsa049770.58052913
107Graft-versus-host disease_Homo sapiens_hsa053320.55645863
108cAMP signaling pathway_Homo sapiens_hsa040240.54994536
109Oxytocin signaling pathway_Homo sapiens_hsa049210.54593856
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54044671
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53660285
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53270623
113Regulation of autophagy_Homo sapiens_hsa041400.52460297
114Fatty acid degradation_Homo sapiens_hsa000710.52398244
115Histidine metabolism_Homo sapiens_hsa003400.52138700
116Sulfur relay system_Homo sapiens_hsa041220.51282321
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46020043
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44621899
119Cardiac muscle contraction_Homo sapiens_hsa042600.44212507
120Metabolic pathways_Homo sapiens_hsa011000.43929286
121Dopaminergic synapse_Homo sapiens_hsa047280.43317778
122Estrogen signaling pathway_Homo sapiens_hsa049150.43212843
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42704778
124ABC transporters_Homo sapiens_hsa020100.42071996
125Cholinergic synapse_Homo sapiens_hsa047250.40852560
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40619121
127Type I diabetes mellitus_Homo sapiens_hsa049400.40564317
128Dilated cardiomyopathy_Homo sapiens_hsa054140.38540275
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38378715
130Gastric acid secretion_Homo sapiens_hsa049710.37601831
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36091669
132Inositol phosphate metabolism_Homo sapiens_hsa005620.35641583
133Sphingolipid metabolism_Homo sapiens_hsa006000.35166817
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33742573
135AMPK signaling pathway_Homo sapiens_hsa041520.33645162
136Synaptic vesicle cycle_Homo sapiens_hsa047210.32827379
137MAPK signaling pathway_Homo sapiens_hsa040100.32770995
138Circadian rhythm_Homo sapiens_hsa047100.32082740
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.31458866
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31068089
141Viral carcinogenesis_Homo sapiens_hsa052030.30413603
142Chemical carcinogenesis_Homo sapiens_hsa052040.29464771
143Legionellosis_Homo sapiens_hsa051340.28422142
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28239251
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27622574
146Renin secretion_Homo sapiens_hsa049240.26643374
147VEGF signaling pathway_Homo sapiens_hsa043700.25038970
148Renin-angiotensin system_Homo sapiens_hsa046140.23417807
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.22943746
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22420777
151Herpes simplex infection_Homo sapiens_hsa051680.22401349
152Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21574939
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20807316
154Retinol metabolism_Homo sapiens_hsa008300.20532304
155Central carbon metabolism in cancer_Homo sapiens_hsa052300.19383424
156Endocytosis_Homo sapiens_hsa041440.17560680
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17233845
158Systemic lupus erythematosus_Homo sapiens_hsa053220.16262186
159Long-term potentiation_Homo sapiens_hsa047200.14032133
160HTLV-I infection_Homo sapiens_hsa051660.13701208
161Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11676604
162Taste transduction_Homo sapiens_hsa047420.11462106
163Protein digestion and absorption_Homo sapiens_hsa049740.10661870
164Vascular smooth muscle contraction_Homo sapiens_hsa042700.10653040

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