DNAJC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.35589077
2synaptic vesicle maturation (GO:0016188)6.35407438
3locomotory exploration behavior (GO:0035641)5.73112442
4synaptic vesicle exocytosis (GO:0016079)5.67986127
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.65227377
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58083541
7glutamate secretion (GO:0014047)5.55928182
8vocalization behavior (GO:0071625)5.35865001
9regulation of synaptic vesicle exocytosis (GO:2000300)5.30307470
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.09060441
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.99636552
12regulation of glutamate receptor signaling pathway (GO:1900449)4.77549597
13neuron cell-cell adhesion (GO:0007158)4.71414767
14regulation of synaptic vesicle transport (GO:1902803)4.70435976
15neuronal action potential propagation (GO:0019227)4.70120314
16protein localization to synapse (GO:0035418)4.68448455
17neurotransmitter secretion (GO:0007269)4.64714896
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.56975293
19exploration behavior (GO:0035640)4.51297532
20potassium ion homeostasis (GO:0055075)4.46931286
21regulation of neuronal synaptic plasticity (GO:0048168)4.40691266
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.37915669
23axon ensheathment in central nervous system (GO:0032291)4.24938735
24central nervous system myelination (GO:0022010)4.24938735
25layer formation in cerebral cortex (GO:0021819)4.19586297
26synaptic transmission, glutamatergic (GO:0035249)4.16963948
27gamma-aminobutyric acid transport (GO:0015812)4.16736656
28cellular sodium ion homeostasis (GO:0006883)4.08711936
29glutamate receptor signaling pathway (GO:0007215)4.07885321
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07575768
31regulation of synapse structural plasticity (GO:0051823)4.06331468
32amino acid import (GO:0043090)4.05944823
33neuron-neuron synaptic transmission (GO:0007270)4.02515577
34potassium ion import (GO:0010107)4.02298834
35dendritic spine morphogenesis (GO:0060997)3.99792432
36cellular potassium ion homeostasis (GO:0030007)3.98790713
37proline transport (GO:0015824)3.94160107
38negative regulation of dendrite morphogenesis (GO:0050774)3.92632161
39neurotransmitter transport (GO:0006836)3.88885337
40neurotransmitter-gated ion channel clustering (GO:0072578)3.85998733
41long-term memory (GO:0007616)3.85408733
42positive regulation of membrane potential (GO:0045838)3.81433561
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76298364
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75012337
45activation of protein kinase A activity (GO:0034199)3.65670363
46regulation of voltage-gated calcium channel activity (GO:1901385)3.63284871
47sodium ion export (GO:0071436)3.61117718
48regulation of postsynaptic membrane potential (GO:0060078)3.60184861
49regulation of neurotransmitter levels (GO:0001505)3.56335084
50transmission of nerve impulse (GO:0019226)3.56248139
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55690164
52neuron recognition (GO:0008038)3.55663900
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.54087298
54cerebellar Purkinje cell differentiation (GO:0021702)3.53934613
55synaptic vesicle endocytosis (GO:0048488)3.53237213
56regulation of neurotransmitter secretion (GO:0046928)3.52900744
57neuromuscular process controlling posture (GO:0050884)3.51848806
58regulation of synaptic plasticity (GO:0048167)3.51302450
59regulation of synapse maturation (GO:0090128)3.49594507
60positive regulation of dendritic spine development (GO:0060999)3.45365867
61neuromuscular process controlling balance (GO:0050885)3.41627395
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.41260981
63neurotransmitter uptake (GO:0001504)3.41165629
64long-term synaptic potentiation (GO:0060291)3.39015876
65detection of calcium ion (GO:0005513)3.37301578
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.36730949
67positive regulation of synapse maturation (GO:0090129)3.33249914
68regulation of vesicle fusion (GO:0031338)3.32642092
69regulation of dendritic spine morphogenesis (GO:0061001)3.32384470
70cell communication involved in cardiac conduction (GO:0086065)3.31565724
71auditory behavior (GO:0031223)3.31003317
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30977911
73vesicle transport along microtubule (GO:0047496)3.27869071
74axonal fasciculation (GO:0007413)3.27838650
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.27729894
76presynaptic membrane assembly (GO:0097105)3.27366394
77postsynaptic membrane organization (GO:0001941)3.26863179
78regulation of neurotransmitter transport (GO:0051588)3.26613572
79glycine transport (GO:0015816)3.26557144
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.25928948
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22635291
82cell differentiation in hindbrain (GO:0021533)3.19184452
83dendrite morphogenesis (GO:0048813)3.19160041
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17691313
85response to auditory stimulus (GO:0010996)3.17409295
86membrane hyperpolarization (GO:0060081)3.16929641
87positive regulation of neurotransmitter transport (GO:0051590)3.16118543
88presynaptic membrane organization (GO:0097090)3.14987424
89membrane depolarization (GO:0051899)3.14955710
90positive regulation of neurotransmitter secretion (GO:0001956)3.14334515
91synaptic vesicle transport (GO:0048489)3.13527188
92establishment of synaptic vesicle localization (GO:0097480)3.13527188
93establishment of mitochondrion localization (GO:0051654)3.12956635
94membrane depolarization during action potential (GO:0086010)3.12489526
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11639905
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11299179
97acidic amino acid transport (GO:0015800)3.10786325
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08207610
99L-amino acid import (GO:0043092)3.06743758
100adult walking behavior (GO:0007628)3.04815424
101neuronal ion channel clustering (GO:0045161)3.04758166
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04705685
103response to histamine (GO:0034776)3.04132749
104cerebellar granule cell differentiation (GO:0021707)3.03781981
105startle response (GO:0001964)3.03001741
106regulation of dendritic spine development (GO:0060998)3.02851722
107innervation (GO:0060384)3.02478233
108prepulse inhibition (GO:0060134)3.02442883
109synapse assembly (GO:0007416)3.02032382
110organelle transport along microtubule (GO:0072384)3.02022166
111learning (GO:0007612)3.01419303
112synaptic transmission (GO:0007268)3.01370633
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00895294
114cell communication by electrical coupling (GO:0010644)3.00864821
115regulation of synaptic transmission (GO:0050804)2.99633629
116positive regulation of synaptic transmission (GO:0050806)2.99340659
117neuromuscular process (GO:0050905)2.97336562
118mating behavior (GO:0007617)2.96498025
119neuromuscular synaptic transmission (GO:0007274)2.95304661
120cerebellar Purkinje cell layer development (GO:0021680)2.94773890
121regulation of ARF protein signal transduction (GO:0032012)2.94381405
122social behavior (GO:0035176)2.93581330
123intraspecies interaction between organisms (GO:0051703)2.93581330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10153074
2GBX2_23144817_ChIP-Seq_PC3_Human3.62057376
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11968605
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04750341
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02862160
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.87782771
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67696183
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67696183
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.67615230
10DROSHA_22980978_ChIP-Seq_HELA_Human2.60974133
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57115942
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53538761
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53249856
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52310591
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45335105
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41421683
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40251923
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.37696906
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24840966
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21918857
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.14867994
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.14036287
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09190983
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07795416
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07000114
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05789951
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01720156
28AR_21572438_ChIP-Seq_LNCaP_Human1.90556802
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85184381
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84615840
31TAF15_26573619_Chip-Seq_HEK293_Human1.80695539
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80518839
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68426228
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.65867415
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64191244
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55508131
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.55202235
38ZNF274_21170338_ChIP-Seq_K562_Hela1.42685528
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38251187
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37111399
41* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36100415
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34698599
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34446170
44P300_19829295_ChIP-Seq_ESCs_Human1.33355488
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32691853
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.29270410
47STAT3_23295773_ChIP-Seq_U87_Human1.27824000
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.27194563
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24865325
50* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24144306
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23425577
52AR_19668381_ChIP-Seq_PC3_Human1.22373705
53* AR_25329375_ChIP-Seq_VCAP_Human1.20789466
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18398737
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17710697
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16514913
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16440079
58IGF1R_20145208_ChIP-Seq_DFB_Human1.16165458
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13819619
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13336868
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12205945
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11742595
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.11607979
64TCF4_23295773_ChIP-Seq_U87_Human1.11484613
65* TET1_21490601_ChIP-Seq_MESCs_Mouse1.10348607
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10151318
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.09679288
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.07982606
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.07317648
70RNF2_27304074_Chip-Seq_NSC_Mouse1.05846180
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05643829
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03921617
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.03844820
74* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03684415
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03647945
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03096523
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01648520
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01619638
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00890241
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00613334
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00604920
82* KDM2B_26808549_Chip-Seq_K562_Human1.00470954
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99833846
84SMAD3_21741376_ChIP-Seq_ESCs_Human0.99264599
85POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98696967
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98394259
87AHR_22903824_ChIP-Seq_MCF-7_Human0.97948714
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.97489546
89SOX9_26525672_Chip-Seq_HEART_Mouse0.96541116
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95034991
91RUNX2_22187159_ChIP-Seq_PCA_Human0.94837541
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94591255
93TP53_16413492_ChIP-PET_HCT116_Human0.93957138
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92910604
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92367807
96* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92110891
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.91788631
98FUS_26573619_Chip-Seq_HEK293_Human0.91389106
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90479914
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90211226
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89884505
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89810553
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88419090
104SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87512480
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86556087
106ER_23166858_ChIP-Seq_MCF-7_Human0.85958308
107* SMAD_19615063_ChIP-ChIP_OVARY_Human0.85819999
108* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85565998
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85219467
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.85110713
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84546116
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84282934
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.83462492
114DPY_21335234_ChIP-Seq_ESCs_Mouse0.81040123
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79852037
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79378316
117* JUN_21703547_ChIP-Seq_K562_Human0.77792756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43531031
2MP0003880_abnormal_central_pattern4.89790098
3MP0003635_abnormal_synaptic_transmissio4.16781202
4MP0004270_analgesia3.93644066
5MP0009745_abnormal_behavioral_response3.41179794
6MP0002064_seizures3.28231082
7MP0009046_muscle_twitch3.28118573
8MP0002063_abnormal_learning/memory/cond3.26508115
9MP0001968_abnormal_touch/_nociception3.07725324
10MP0005423_abnormal_somatic_nervous2.95853073
11MP0002734_abnormal_mechanical_nocicepti2.80195024
12MP0002572_abnormal_emotion/affect_behav2.78135540
13MP0002272_abnormal_nervous_system2.74881440
14MP0001486_abnormal_startle_reflex2.60986780
15MP0002822_catalepsy2.30333787
16MP0002736_abnormal_nociception_after2.28858819
17MP0002735_abnormal_chemical_nociception2.26271889
18MP0001501_abnormal_sleep_pattern2.25064160
19MP0001440_abnormal_grooming_behavior2.10060956
20MP0002733_abnormal_thermal_nociception2.09823928
21MP0001970_abnormal_pain_threshold2.03977110
22MP0002067_abnormal_sensory_capabilities2.03175930
23MP0009780_abnormal_chondrocyte_physiolo2.00691696
24MP0008569_lethality_at_weaning1.99643602
25MP0003329_amyloid_beta_deposits1.89706027
26MP0004147_increased_porphyrin_level1.85099497
27MP0002184_abnormal_innervation1.80491318
28MP0005386_behavior/neurological_phenoty1.80130111
29MP0004924_abnormal_behavior1.80130111
30MP0000778_abnormal_nervous_system1.77458667
31MP0002909_abnormal_adrenal_gland1.76307509
32* MP0004811_abnormal_neuron_physiology1.75748609
33MP0006276_abnormal_autonomic_nervous1.74688611
34MP0002557_abnormal_social/conspecific_i1.72795674
35MP0004885_abnormal_endolymph1.68593805
36MP0004858_abnormal_nervous_system1.68017859
37MP0005646_abnormal_pituitary_gland1.65242033
38MP0000955_abnormal_spinal_cord1.62136398
39MP0003879_abnormal_hair_cell1.56388163
40MP0001984_abnormal_olfaction1.53123251
41MP0005645_abnormal_hypothalamus_physiol1.51756418
42MP0003787_abnormal_imprinting1.48614235
43MP0002066_abnormal_motor_capabilities/c1.47499603
44* MP0002882_abnormal_neuron_morphology1.47429990
45MP0001905_abnormal_dopamine_level1.44009041
46MP0003633_abnormal_nervous_system1.42880637
47MP0004142_abnormal_muscle_tone1.42635883
48MP0001529_abnormal_vocalization1.35540028
49MP0003122_maternal_imprinting1.30511303
50MP0001502_abnormal_circadian_rhythm1.27405275
51MP0003631_nervous_system_phenotype1.21175625
52MP0003123_paternal_imprinting1.20855924
53MP0002229_neurodegeneration1.19191202
54MP0005551_abnormal_eye_electrophysiolog1.16679788
55MP0001188_hyperpigmentation1.13807126
56MP0000920_abnormal_myelination1.11430984
57MP0002152_abnormal_brain_morphology1.10560702
58MP0000569_abnormal_digit_pigmentation1.09084182
59MP0008872_abnormal_physiological_respon1.05579910
60MP0004742_abnormal_vestibular_system1.04197410
61MP0003634_abnormal_glial_cell0.99227652
62MP0003690_abnormal_glial_cell0.97396114
63MP0004145_abnormal_muscle_electrophysio0.93859543
64MP0002069_abnormal_eating/drinking_beha0.90760624
65MP0003632_abnormal_nervous_system0.90084013
66MP0000013_abnormal_adipose_tissue0.89601419
67MP0008874_decreased_physiological_sensi0.89130615
68MP0001963_abnormal_hearing_physiology0.87444349
69MP0003283_abnormal_digestive_organ0.86097758
70MP0000751_myopathy0.86037978
71MP0001177_atelectasis0.84815117
72MP0005535_abnormal_body_temperature0.83925092
73MP0005394_taste/olfaction_phenotype0.83078192
74MP0005499_abnormal_olfactory_system0.83078192
75MP0002752_abnormal_somatic_nervous0.82270837
76MP0008877_abnormal_DNA_methylation0.82042334
77MP0010386_abnormal_urinary_bladder0.80613721
78MP0001485_abnormal_pinna_reflex0.80457994
79MP0000631_abnormal_neuroendocrine_gland0.78520629
80MP0004043_abnormal_pH_regulation0.78350951
81MP0005409_darkened_coat_color0.78267384
82MP0000604_amyloidosis0.76652295
83MP0004085_abnormal_heartbeat0.75529489
84MP0003075_altered_response_to0.75111164
85MP0008961_abnormal_basal_metabolism0.73261874
86MP0002090_abnormal_vision0.72507829
87MP0003172_abnormal_lysosome_physiology0.71323434
88MP0003121_genomic_imprinting0.69002246
89MP0006072_abnormal_retinal_apoptosis0.63499120
90MP0001348_abnormal_lacrimal_gland0.61628106
91MP0002638_abnormal_pupillary_reflex0.61025540
92MP0001986_abnormal_taste_sensitivity0.60853684
93MP0001664_abnormal_digestion0.60418614
94MP0001299_abnormal_eye_distance/0.60291831
95* MP0010768_mortality/aging0.60283239
96* MP0010770_preweaning_lethality0.59643815
97* MP0002082_postnatal_lethality0.59643815
98MP0004215_abnormal_myocardial_fiber0.58710504
99MP0005623_abnormal_meninges_morphology0.58162834
100MP0002876_abnormal_thyroid_physiology0.58090225
101MP0004233_abnormal_muscle_weight0.57723751
102MP0001346_abnormal_lacrimal_gland0.57145957
103MP0003137_abnormal_impulse_conducting0.56598174
104MP0005187_abnormal_penis_morphology0.56360084
105MP0002837_dystrophic_cardiac_calcinosis0.56327730
106MP0001943_abnormal_respiration0.56295899
107MP0000579_abnormal_nail_morphology0.54483196
108* MP0010769_abnormal_survival0.53484098
109MP0005253_abnormal_eye_physiology0.53240224
110* MP0003956_abnormal_body_size0.52926109
111MP0003861_abnormal_nervous_system0.52546917
112MP0005167_abnormal_blood-brain_barrier0.52513030
113MP0004484_altered_response_of0.51985710
114MP0000639_abnormal_adrenal_gland0.51569494
115MP0001731_abnormal_postnatal_growth0.41565595
116MP0002873_normal_phenotype0.40583866

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.46726286
2Myokymia (HP:0002411)6.82337740
3Focal seizures (HP:0007359)5.69192973
4Visual hallucinations (HP:0002367)5.49752651
5Epileptic encephalopathy (HP:0200134)4.77322461
6Atonic seizures (HP:0010819)4.70237799
7Progressive cerebellar ataxia (HP:0002073)4.44561989
8Febrile seizures (HP:0002373)4.32831545
9Absence seizures (HP:0002121)4.25036096
10Action tremor (HP:0002345)4.11112107
11Supranuclear gaze palsy (HP:0000605)3.94251979
12Generalized tonic-clonic seizures (HP:0002069)3.89948681
13Dialeptic seizures (HP:0011146)3.89689755
14Ankle clonus (HP:0011448)3.84717265
15Broad-based gait (HP:0002136)3.54223393
16Gaze-evoked nystagmus (HP:0000640)3.45956233
17Poor eye contact (HP:0000817)3.31812536
18Dysdiadochokinesis (HP:0002075)3.30085672
19Depression (HP:0000716)3.29726525
20Papilledema (HP:0001085)3.29599765
21Impaired vibration sensation in the lower limbs (HP:0002166)3.29495084
22Dysmetria (HP:0001310)3.26253212
23Truncal ataxia (HP:0002078)3.22067147
24Urinary bladder sphincter dysfunction (HP:0002839)3.19989759
25Cerebral hypomyelination (HP:0006808)3.15848817
26Mutism (HP:0002300)3.14961342
27Abnormal eating behavior (HP:0100738)3.06610104
28Anxiety (HP:0000739)3.04103102
29Hyperventilation (HP:0002883)3.01558617
30Impaired social interactions (HP:0000735)3.00201776
31Abnormal social behavior (HP:0012433)3.00201776
32Scanning speech (HP:0002168)2.97574953
33Spastic gait (HP:0002064)2.95110460
34Tetraplegia (HP:0002445)2.89241497
35Urinary urgency (HP:0000012)2.85957452
36Abnormality of the corticospinal tract (HP:0002492)2.83427968
37Intention tremor (HP:0002080)2.82869778
38Progressive inability to walk (HP:0002505)2.82090084
39Neurofibrillary tangles (HP:0002185)2.80766429
40Obstructive sleep apnea (HP:0002870)2.80584745
41Pheochromocytoma (HP:0002666)2.77640526
42Genetic anticipation (HP:0003743)2.76147038
43Impaired smooth pursuit (HP:0007772)2.76057275
44Amblyopia (HP:0000646)2.68035593
45Excessive salivation (HP:0003781)2.67788732
46Drooling (HP:0002307)2.67788732
47Cerebral inclusion bodies (HP:0100314)2.67683593
48Limb dystonia (HP:0002451)2.63379663
49Termporal pattern (HP:0011008)2.58119449
50Insidious onset (HP:0003587)2.58119449
51Morphological abnormality of the pyramidal tract (HP:0002062)2.54207501
52* Postural instability (HP:0002172)2.54101283
53Abnormality of the lower motor neuron (HP:0002366)2.54031380
54Abnormality of binocular vision (HP:0011514)2.53519425
55Diplopia (HP:0000651)2.53519425
56Torticollis (HP:0000473)2.53455253
57Hemiparesis (HP:0001269)2.53374091
58Abnormality of ocular smooth pursuit (HP:0000617)2.42715416
59Hemiplegia (HP:0002301)2.41774621
60Epileptiform EEG discharges (HP:0011182)2.40136830
61Neuroendocrine neoplasm (HP:0100634)2.36486537
62Lower limb muscle weakness (HP:0007340)2.36484987
63Focal dystonia (HP:0004373)2.36244066
64Absent speech (HP:0001344)2.34600926
65Megalencephaly (HP:0001355)2.32963542
66EEG with generalized epileptiform discharges (HP:0011198)2.32815241
67Sleep apnea (HP:0010535)2.32718977
68Dysmetric saccades (HP:0000641)2.27546473
69Spastic tetraparesis (HP:0001285)2.27481647
70Stereotypic behavior (HP:0000733)2.26267106
71Fetal akinesia sequence (HP:0001989)2.25587403
72* Bradykinesia (HP:0002067)2.24656768
73Agitation (HP:0000713)2.24199777
74Ventricular fibrillation (HP:0001663)2.24058196
75Choreoathetosis (HP:0001266)2.23437367
76Impaired vibratory sensation (HP:0002495)2.21998401
77Apathy (HP:0000741)2.21663067
78Hypsarrhythmia (HP:0002521)2.21062237
79Increased circulating renin level (HP:0000848)2.17576442
80Generalized myoclonic seizures (HP:0002123)2.17507389
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15946595
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.15946595
83Polyphagia (HP:0002591)2.15781818
84Inability to walk (HP:0002540)2.15536615
85Clonus (HP:0002169)2.11786425
86Craniofacial dystonia (HP:0012179)2.11090679
87Status epilepticus (HP:0002133)2.10440714
88CNS hypomyelination (HP:0003429)2.10288264
89Amyotrophic lateral sclerosis (HP:0007354)2.07083021
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05590538
91Peripheral hypomyelination (HP:0007182)2.01360380
92Blue irides (HP:0000635)2.00730299
93Gait ataxia (HP:0002066)1.98916187
94Diminished motivation (HP:0000745)1.98399286
95Akinesia (HP:0002304)1.96898239
96Insomnia (HP:0100785)1.94311951
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93298409
98Psychosis (HP:0000709)1.93054559
99Neuronal loss in central nervous system (HP:0002529)1.91958654
100Paraplegia (HP:0010550)1.91536700
101Bundle branch block (HP:0011710)1.87577720
102Specific learning disability (HP:0001328)1.86428377
103Incomplete penetrance (HP:0003829)1.85736448
104Spastic paraplegia (HP:0001258)1.85281171
105Delusions (HP:0000746)1.84985410
106Diminished movement (HP:0002374)1.83901076
107Annular pancreas (HP:0001734)1.83588067
108Neoplasm of the peripheral nervous system (HP:0100007)1.81182131
109Inappropriate behavior (HP:0000719)1.80979296
110Abnormality of salivation (HP:0100755)1.80320066
111Failure to thrive in infancy (HP:0001531)1.80305418
112Spastic tetraplegia (HP:0002510)1.79992837
113Gait imbalance (HP:0002141)1.79241505
114Aplasia of the phalanges of the hand (HP:0009802)1.78481379
115Aplasia involving bones of the extremities (HP:0009825)1.78481379
116Pointed chin (HP:0000307)1.76029585
117* Rigidity (HP:0002063)1.73962952
118Resting tremor (HP:0002322)1.73899085
119Postural tremor (HP:0002174)1.73665132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.31078916
2MAP3K93.93144306
3EPHA43.65592058
4MARK13.26820285
5MAP3K43.05240953
6MINK12.74466802
7MAP2K72.59673660
8DAPK22.41377673
9PAK62.33161297
10MAP3K122.23853059
11NTRK22.16010680
12KSR22.05816024
13NTRK12.03124192
14MAP2K41.94275680
15CDK191.90117406
16PRKD31.87689076
17CASK1.86938055
18CAMKK11.86344242
19PNCK1.60525822
20CDK51.59900617
21TNIK1.54208918
22RIPK41.53975192
23DAPK11.45420453
24GRK51.44765428
25KSR11.44741422
26PRPF4B1.40746552
27CAMKK21.37199482
28PLK21.35980192
29UHMK11.35761255
30MAPK131.30203475
31ARAF1.29806563
32OXSR11.27355517
33STK381.22496473
34PRKCG1.21081405
35MAP3K21.18932570
36MAP3K131.12886618
37RIPK11.08996249
38TYRO31.07380766
39FES1.04593631
40PHKG21.02323882
41PHKG11.02323882
42SIK21.02109760
43SGK4940.99947374
44SGK2230.99947374
45CAMK2A0.99190073
46CDK180.99001566
47CDK150.98154917
48CDK140.96331254
49STK110.93764922
50CAMK10.91551791
51CSNK1G20.88200364
52PRKCH0.87772180
53CAMK2B0.86930419
54RET0.86899367
55CDK11A0.85724142
56LATS20.84604825
57PINK10.82861973
58PAK30.80651946
59ALK0.80411394
60TAOK10.79735786
61WNK10.73828294
62MAPK120.72113135
63RAF10.71206094
64STK390.70555835
65PDK10.68970478
66SGK20.67551994
67LMTK20.66260803
68MARK20.65138890
69MAPKAPK50.64468985
70SGK10.63280026
71PDPK10.63085952
72NEK60.61939422
73DYRK1A0.61611749
74SGK30.61179449
75SCYL20.60342854
76MAP3K10.60060019
77WNK30.58309075
78TNK20.57886421
79CAMK1G0.56376862
80BRAF0.56373286
81CAMK2D0.55511300
82CAMK2G0.53427086
83BMPR20.53019727
84PTK2B0.52263886
85RPS6KA30.48992225
86PRKCZ0.46753985
87PRKCE0.46714853
88CCNB10.46179020
89MAPK100.45908452
90FYN0.44982359
91CDC42BPA0.44829907
92NEK10.43034770
93FGFR20.41181235
94WNK40.41054624
95CAMK40.40987640
96CSNK1G30.40013241
97BCR0.39423442
98MAP3K110.38737392
99ROCK20.38155982
100MAP3K70.37800081
101FGR0.36660633
102BRSK10.36396536
103DAPK30.35805659
104FER0.34375444
105AKT30.34337439
106PKN10.34151537
107CSNK1E0.32616470
108PRKCA0.31542403
109PRKCB0.31436531
110CSNK1D0.30552702
111PRKG10.29217175
112GSK3B0.28678183
113RPS6KB10.25993435
114MAP2K10.25582558

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66302614
2Synaptic vesicle cycle_Homo sapiens_hsa047213.57781571
3GABAergic synapse_Homo sapiens_hsa047272.81510393
4Olfactory transduction_Homo sapiens_hsa047402.77769968
5Circadian entrainment_Homo sapiens_hsa047132.69450484
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67272987
7Long-term potentiation_Homo sapiens_hsa047202.63321552
8Glutamatergic synapse_Homo sapiens_hsa047242.61309591
9Morphine addiction_Homo sapiens_hsa050322.50933180
10Amphetamine addiction_Homo sapiens_hsa050312.45123370
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35279097
12Dopaminergic synapse_Homo sapiens_hsa047282.21965300
13Salivary secretion_Homo sapiens_hsa049702.16353849
14Insulin secretion_Homo sapiens_hsa049112.09233519
15Gastric acid secretion_Homo sapiens_hsa049711.93032813
16Cholinergic synapse_Homo sapiens_hsa047251.92492575
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79036109
18Taste transduction_Homo sapiens_hsa047421.76803685
19Long-term depression_Homo sapiens_hsa047301.75294312
20Serotonergic synapse_Homo sapiens_hsa047261.73021320
21Cocaine addiction_Homo sapiens_hsa050301.70285092
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64599076
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64420799
24Renin secretion_Homo sapiens_hsa049241.63552903
25Oxytocin signaling pathway_Homo sapiens_hsa049211.58471446
26Collecting duct acid secretion_Homo sapiens_hsa049661.57546045
27Calcium signaling pathway_Homo sapiens_hsa040201.48549877
28GnRH signaling pathway_Homo sapiens_hsa049121.42682825
29Gap junction_Homo sapiens_hsa045401.35864782
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34008007
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32728756
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22535112
33cAMP signaling pathway_Homo sapiens_hsa040241.22492936
34Type II diabetes mellitus_Homo sapiens_hsa049301.21845398
35Phototransduction_Homo sapiens_hsa047441.21717211
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18244188
37Estrogen signaling pathway_Homo sapiens_hsa049151.15401342
38Nitrogen metabolism_Homo sapiens_hsa009101.12795561
39Vibrio cholerae infection_Homo sapiens_hsa051101.07446170
40ErbB signaling pathway_Homo sapiens_hsa040121.06833545
41Axon guidance_Homo sapiens_hsa043601.06618195
42Glioma_Homo sapiens_hsa052141.05918450
43Vitamin B6 metabolism_Homo sapiens_hsa007501.05467866
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01548321
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99377889
46Melanogenesis_Homo sapiens_hsa049160.99042639
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97038367
48Cardiac muscle contraction_Homo sapiens_hsa042600.95229809
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.90734129
50Oocyte meiosis_Homo sapiens_hsa041140.89404204
51Pancreatic secretion_Homo sapiens_hsa049720.88236667
52Dorso-ventral axis formation_Homo sapiens_hsa043200.87934424
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.84560698
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80438802
55Thyroid hormone synthesis_Homo sapiens_hsa049180.80348269
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73482075
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73407789
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73321627
59Choline metabolism in cancer_Homo sapiens_hsa052310.70668287
60MAPK signaling pathway_Homo sapiens_hsa040100.70532830
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64779395
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63161375
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.62109073
64Dilated cardiomyopathy_Homo sapiens_hsa054140.61410217
65Alcoholism_Homo sapiens_hsa050340.58921972
66Ras signaling pathway_Homo sapiens_hsa040140.58222092
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56877001
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56862454
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.56734020
70VEGF signaling pathway_Homo sapiens_hsa043700.56360348
71Inositol phosphate metabolism_Homo sapiens_hsa005620.53932763
72Type I diabetes mellitus_Homo sapiens_hsa049400.53459097
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53280101
74* Endocytosis_Homo sapiens_hsa041440.52872946
75Glucagon signaling pathway_Homo sapiens_hsa049220.49828714
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49050301
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48427616
78mTOR signaling pathway_Homo sapiens_hsa041500.47732470
79Rap1 signaling pathway_Homo sapiens_hsa040150.47248581
80Renal cell carcinoma_Homo sapiens_hsa052110.45309439
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45163506
82Bile secretion_Homo sapiens_hsa049760.44465605
83Circadian rhythm_Homo sapiens_hsa047100.43653567
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42152722
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41210343
86Fatty acid biosynthesis_Homo sapiens_hsa000610.40819196
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40504100
88Endometrial cancer_Homo sapiens_hsa052130.39845468
89Prion diseases_Homo sapiens_hsa050200.39405534
90Insulin signaling pathway_Homo sapiens_hsa049100.38519070
91Wnt signaling pathway_Homo sapiens_hsa043100.37941743
92Alzheimers disease_Homo sapiens_hsa050100.37811370
93Arginine biosynthesis_Homo sapiens_hsa002200.37775979
94Mineral absorption_Homo sapiens_hsa049780.36575538
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36172808
96Non-small cell lung cancer_Homo sapiens_hsa052230.35120243
97Ovarian steroidogenesis_Homo sapiens_hsa049130.33586238
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32720707
99Chemokine signaling pathway_Homo sapiens_hsa040620.32549683
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32102947
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.31051544
102Arginine and proline metabolism_Homo sapiens_hsa003300.30906825
103AMPK signaling pathway_Homo sapiens_hsa041520.29548952
104African trypanosomiasis_Homo sapiens_hsa051430.27904479
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27327816
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25640903
107Tight junction_Homo sapiens_hsa045300.25448110
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25094076
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22952337
110Colorectal cancer_Homo sapiens_hsa052100.22320944
111Prolactin signaling pathway_Homo sapiens_hsa049170.19220766

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