DNAJC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)4.75021756
2folic acid-containing compound biosynthetic process (GO:0009396)4.57837361
3negative regulation of histone methylation (GO:0031061)4.48643119
4maturation of 5.8S rRNA (GO:0000460)4.40893917
5pre-miRNA processing (GO:0031054)4.25088854
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.20308441
7regulation of translational termination (GO:0006449)4.11291347
8rRNA catabolic process (GO:0016075)4.10952387
9peptidyl-arginine omega-N-methylation (GO:0035247)3.88450029
10regulation of centriole replication (GO:0046599)3.79830024
11peptidyl-arginine N-methylation (GO:0035246)3.77290982
12peptidyl-arginine methylation (GO:0018216)3.77290982
13DNA strand elongation involved in DNA replication (GO:0006271)3.76104567
14L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.75326529
15regulation of histone H3-K9 methylation (GO:0051570)3.71918092
16regulation of DNA endoreduplication (GO:0032875)3.70343681
17ribosome biogenesis (GO:0042254)3.64141726
18spliceosomal tri-snRNP complex assembly (GO:0000244)3.63767423
19DNA replication initiation (GO:0006270)3.62178242
20meiotic chromosome segregation (GO:0045132)3.60708909
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.58718149
22DNA strand elongation (GO:0022616)3.55785649
23negative regulation of RNA splicing (GO:0033119)3.55622759
24nuclear pore organization (GO:0006999)3.51792317
25mitochondrial RNA metabolic process (GO:0000959)3.51103437
26replication fork processing (GO:0031297)3.46666786
27protein localization to kinetochore (GO:0034501)3.45159942
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.39850711
29negative regulation of mRNA processing (GO:0050686)3.36113472
30double-strand break repair via nonhomologous end joining (GO:0006303)3.35583339
31non-recombinational repair (GO:0000726)3.35583339
32dosage compensation (GO:0007549)3.35410266
33ncRNA catabolic process (GO:0034661)3.35126015
34sister chromatid segregation (GO:0000819)3.32783911
35amino acid activation (GO:0043038)3.31543054
36tRNA aminoacylation (GO:0043039)3.31543054
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.29804954
38nuclear pore complex assembly (GO:0051292)3.29066931
39response to pheromone (GO:0019236)3.27144526
40tRNA aminoacylation for protein translation (GO:0006418)3.24801783
41protein-DNA complex disassembly (GO:0032986)3.24236797
42nucleosome disassembly (GO:0006337)3.24236797
43purine nucleobase biosynthetic process (GO:0009113)3.23972260
44positive regulation of gamma-delta T cell activation (GO:0046645)3.22586565
45mitotic sister chromatid segregation (GO:0000070)3.21834543
46histone arginine methylation (GO:0034969)3.19880756
47mitotic nuclear envelope disassembly (GO:0007077)3.19829044
48tetrahydrofolate metabolic process (GO:0046653)3.18676701
49positive regulation of RNA splicing (GO:0033120)3.18276171
50histone H4-K5 acetylation (GO:0043981)3.17056145
51histone H4-K8 acetylation (GO:0043982)3.17056145
52viral mRNA export from host cell nucleus (GO:0046784)3.16814670
53pteridine-containing compound biosynthetic process (GO:0042559)3.15620409
54establishment of integrated proviral latency (GO:0075713)3.14140819
55regulation of centrosome cycle (GO:0046605)3.13321158
56nuclear envelope disassembly (GO:0051081)3.13017178
57membrane disassembly (GO:0030397)3.13017178
58telomere maintenance via semi-conservative replication (GO:0032201)3.12657404
59positive regulation of histone H3-K4 methylation (GO:0051571)3.12058783
60positive regulation of gene expression, epigenetic (GO:0045815)3.10215379
61peptidyl-histidine modification (GO:0018202)3.09398754
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.09354680
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.09354680
64isotype switching (GO:0045190)3.09354680
65methionine biosynthetic process (GO:0009086)3.08793917
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08741991
67regulation of translational fidelity (GO:0006450)3.07905558
68DNA unwinding involved in DNA replication (GO:0006268)3.07336732
69pseudouridine synthesis (GO:0001522)3.06700642
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05694179
71histone H2A monoubiquitination (GO:0035518)3.05538967
72positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.04997365
73rRNA processing (GO:0006364)3.04637154
74regulation of gamma-delta T cell differentiation (GO:0045586)3.04250854
75B cell receptor signaling pathway (GO:0050853)3.03563384
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03511970
77regulation of mitotic spindle checkpoint (GO:1903504)3.03511970
78protein K6-linked ubiquitination (GO:0085020)3.02917803
79rRNA metabolic process (GO:0016072)3.01015372
80mitotic chromosome condensation (GO:0007076)2.99039057
81negative regulation of mRNA metabolic process (GO:1903312)2.98912560
82intra-S DNA damage checkpoint (GO:0031573)2.96058833
83DNA damage response, detection of DNA damage (GO:0042769)2.95900936
84histone H2A acetylation (GO:0043968)2.95142613
85IMP metabolic process (GO:0046040)2.93818477
86aspartate family amino acid biosynthetic process (GO:0009067)2.93700203
87histone H4-K16 acetylation (GO:0043984)2.92287152
88peptidyl-lysine dimethylation (GO:0018027)2.92274021
89mitotic sister chromatid cohesion (GO:0007064)2.90781781
90tRNA modification (GO:0006400)2.87844928
91double-strand break repair via homologous recombination (GO:0000724)2.87791889
92recombinational repair (GO:0000725)2.87580497
93spliceosomal snRNP assembly (GO:0000387)2.87448337
94protein localization to chromosome, centromeric region (GO:0071459)2.86445568
95tRNA metabolic process (GO:0006399)2.86288103
96DNA duplex unwinding (GO:0032508)2.85332836
97L-methionine salvage (GO:0071267)2.85056166
98L-methionine biosynthetic process (GO:0071265)2.85056166
99amino acid salvage (GO:0043102)2.85056166
100telomere maintenance via recombination (GO:0000722)2.83801674
101DNA geometric change (GO:0032392)2.83793517
102transcription from mitochondrial promoter (GO:0006390)2.83606279
103NLS-bearing protein import into nucleus (GO:0006607)2.83385198
104determination of adult lifespan (GO:0008340)2.82849412
105mRNA splicing, via spliceosome (GO:0000398)2.82809733
106RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82809733
107ribonucleoprotein complex biogenesis (GO:0022613)2.82360769
108aspartate family amino acid catabolic process (GO:0009068)2.82266634
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81524626
110regulation of centrosome duplication (GO:0010824)2.79904865
111respiratory chain complex IV assembly (GO:0008535)2.78867185
112histone H4 acetylation (GO:0043967)2.78723006
113postreplication repair (GO:0006301)2.78637506
114negative regulation of histone modification (GO:0031057)2.78392313
115DNA replication-dependent nucleosome organization (GO:0034723)2.78151767
116DNA replication-dependent nucleosome assembly (GO:0006335)2.78151767
117somatic recombination of immunoglobulin gene segments (GO:0016447)2.78135826
118sulfur amino acid biosynthetic process (GO:0000097)2.77632067
119histone H4-K12 acetylation (GO:0043983)2.77603641
120RNA splicing, via transesterification reactions (GO:0000375)2.77424828
121regulation of RNA export from nucleus (GO:0046831)2.77264388
122ubiquinone biosynthetic process (GO:0006744)2.76737638
123regulation of sister chromatid cohesion (GO:0007063)2.76505938
124IMP biosynthetic process (GO:0006188)2.76500942
125chromatin silencing (GO:0006342)2.74926289
126negative regulation of chromatin modification (GO:1903309)2.74503511
127kinetochore organization (GO:0051383)2.74245722
128ncRNA processing (GO:0034470)2.73518415
129somatic diversification of immunoglobulins (GO:0016445)2.73439202
130mitotic recombination (GO:0006312)2.72850714
131ncRNA metabolic process (GO:0034660)2.72332313
132cullin deneddylation (GO:0010388)2.72328795
133regulation of DNA damage checkpoint (GO:2000001)2.72009194
134positive regulation of synapse maturation (GO:0090129)2.70792775
135nuclear envelope organization (GO:0006998)2.70617154
136chromatin remodeling at centromere (GO:0031055)2.70433944
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.70024517
138somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67637882
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.67637882
140regulation of NFAT protein import into nucleus (GO:0051532)2.66791561
141mitotic G1 DNA damage checkpoint (GO:0031571)2.66605702
142V(D)J recombination (GO:0033151)2.65180402
143negative regulation of gene expression, epigenetic (GO:0045814)2.64696587
144alternative mRNA splicing, via spliceosome (GO:0000380)2.63632129
145regulation of spindle organization (GO:0090224)2.61819836
146heterochromatin organization (GO:0070828)2.60283535
147histone H3-K9 demethylation (GO:0033169)2.59755185
148regulation of telomere maintenance via telomerase (GO:0032210)2.59281058
149negative regulation of microtubule polymerization (GO:0031115)2.57734688
150negative regulation of gene silencing (GO:0060969)2.57309202
151mRNA transport (GO:0051028)2.56917756
152RNA stabilization (GO:0043489)2.55117744
153mRNA stabilization (GO:0048255)2.55117744
154regulation of gamma-delta T cell activation (GO:0046643)2.54666614
155formation of translation preinitiation complex (GO:0001731)2.54430617
156glucocorticoid receptor signaling pathway (GO:0042921)2.54306520
157ATP-dependent chromatin remodeling (GO:0043044)2.53688641
158nucleobase biosynthetic process (GO:0046112)2.53588231
159ribosome assembly (GO:0042255)2.53099094
160gene silencing (GO:0016458)2.51083720
161protein localization to chromosome (GO:0034502)2.50477967
162peptidyl-arginine modification (GO:0018195)2.48888262
163intracellular estrogen receptor signaling pathway (GO:0030520)2.47577339
164RNA export from nucleus (GO:0006405)2.47522141
165L-serine transport (GO:0015825)2.47436644
166mRNA export from nucleus (GO:0006406)2.47296623
167negative regulation of cell size (GO:0045792)2.45247528
168synaptic vesicle maturation (GO:0016188)2.45070962
169sodium ion export (GO:0071436)2.44875493
170pore complex assembly (GO:0046931)2.43054363
171positive regulation of chromosome segregation (GO:0051984)2.42890961
172regulation of chromosome segregation (GO:0051983)2.41466193
173translesion synthesis (GO:0019985)2.40943157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.40128333
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.55610717
3MYC_22102868_ChIP-Seq_BL_Human4.32883414
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14685619
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.63145570
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.08616978
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83793902
8* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73534627
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.66351786
10* CIITA_25753668_ChIP-Seq_RAJI_Human2.65276774
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62156641
12ELK1_19687146_ChIP-ChIP_HELA_Human2.46677376
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41936833
14* MYC_18555785_ChIP-Seq_MESCs_Mouse2.34416374
15DCP1A_22483619_ChIP-Seq_HELA_Human2.34390093
16ZNF274_21170338_ChIP-Seq_K562_Hela2.30912957
17FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18291220
18* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13132861
19CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.11097067
20VDR_21846776_ChIP-Seq_THP-1_Human2.09394853
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06670907
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03852377
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03555732
24MYC_18940864_ChIP-ChIP_HL60_Human2.01089026
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00229493
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.96092717
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.91190998
28XRN2_22483619_ChIP-Seq_HELA_Human1.87152301
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85432798
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84879183
31KDM2B_26808549_Chip-Seq_DND41_Human1.80820130
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76945972
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73865318
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.70675765
35* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70080252
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70012217
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69918464
38* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68545556
39TCF7_22412390_ChIP-Seq_EML_Mouse1.67363518
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65758017
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64598053
42* KDM5A_27292631_Chip-Seq_BREAST_Human1.63492412
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62425131
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62179373
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61246213
46UTX_26944678_Chip-Seq_JUKART_Human1.60646272
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.60548503
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56862179
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56242305
50CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.55247417
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54677949
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53709986
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52873248
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52522883
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.51953785
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51672076
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51508811
58EWS_26573619_Chip-Seq_HEK293_Human1.49676220
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.49218775
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.49149569
61* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47538604
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46854422
63* ETS1_20019798_ChIP-Seq_JURKAT_Human1.45426750
64* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44234876
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.41899165
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40671758
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40363560
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35830193
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35541940
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34335863
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32432867
72* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32382931
73* MAF_26560356_Chip-Seq_TH1_Human1.31146110
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.28196196
75* GABP_19822575_ChIP-Seq_HepG2_Human1.27726336
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27458195
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.25370245
78FOXP3_21729870_ChIP-Seq_TREG_Human1.24455382
79VDR_23849224_ChIP-Seq_CD4+_Human1.24402195
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22637029
81TFEB_21752829_ChIP-Seq_HELA_Human1.20868688
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20712407
83* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20195731
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19792377
85FUS_26573619_Chip-Seq_HEK293_Human1.19577763
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18153918
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.17837175
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15148134
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14916165
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.14892841
91* RARB_27405468_Chip-Seq_BRAIN_Mouse1.14665383
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13614318
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13051858
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11992261
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11451719
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10513300
97AR_21909140_ChIP-Seq_LNCAP_Human1.10191325
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09570059
99P68_20966046_ChIP-Seq_HELA_Human1.08976135
100MYB_26560356_Chip-Seq_TH2_Human1.08341776
101* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07482947
102* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07282630
103CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07204817
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05655903
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04924896
106MYB_26560356_Chip-Seq_TH1_Human1.04603274
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03483028
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03249027
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02533422
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02199977
111STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01917297
112TTF2_22483619_ChIP-Seq_HELA_Human1.01837561
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01837434
114* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01244138
115ZNF263_19887448_ChIP-Seq_K562_Human1.00620586
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.00379516
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.99820663
118PHF8_20622854_ChIP-Seq_HELA_Human0.98005917
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.97549676
120* MAF_26560356_Chip-Seq_TH2_Human0.97443417
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96678686
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96232040
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96006627
124* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95448884
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93486840
126NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93180908
127VDR_22108803_ChIP-Seq_LS180_Human0.92601247
128LXR_22292898_ChIP-Seq_THP-1_Human0.91745842
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.91577193
130EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90389928
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89485826
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88369010
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84838765
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84714541
135IGF1R_20145208_ChIP-Seq_DFB_Human0.84156294
136IRF1_19129219_ChIP-ChIP_H3396_Human0.84036999
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.83655078
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79070470
139TP53_22573176_ChIP-Seq_HFKS_Human0.78800109
140HOXB7_26014856_ChIP-Seq_BT474_Human0.75883305
141FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75525126
142POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75415829
143* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75094103
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74721043
145TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74070347
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73774911
147CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.71105201
148ELF5_23300383_ChIP-Seq_T47D_Human0.70028119
149HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.67515598
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.66471571
151SOX2_16153702_ChIP-ChIP_HESCs_Human0.65646546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.22959116
2MP0010094_abnormal_chromosome_stability3.06800127
3MP0003693_abnormal_embryo_hatching2.99792409
4MP0003077_abnormal_cell_cycle2.74417168
5MP0008877_abnormal_DNA_methylation2.73194341
6MP0004957_abnormal_blastocyst_morpholog2.72869748
7MP0003787_abnormal_imprinting2.67660745
8MP0002653_abnormal_ependyma_morphology2.34543727
9MP0004859_abnormal_synaptic_plasticity2.32578734
10MP0001730_embryonic_growth_arrest2.27216268
11MP0002396_abnormal_hematopoietic_system2.20205566
12MP0005076_abnormal_cell_differentiation2.15486688
13MP0000350_abnormal_cell_proliferation2.14581904
14MP0006072_abnormal_retinal_apoptosis1.97475906
15MP0010234_abnormal_vibrissa_follicle1.94453459
16MP0003195_calcinosis1.93570164
17MP0004233_abnormal_muscle_weight1.92242069
18MP0003123_paternal_imprinting1.89152313
19MP0010352_gastrointestinal_tract_polyps1.88122076
20MP0009697_abnormal_copulation1.87322352
21MP0006035_abnormal_mitochondrial_morpho1.86339285
22MP0008007_abnormal_cellular_replicative1.76843301
23MP0003121_genomic_imprinting1.76195897
24MP0008058_abnormal_DNA_repair1.75918299
25MP0001849_ear_inflammation1.73484527
26MP0008961_abnormal_basal_metabolism1.70795108
27MP0002084_abnormal_developmental_patter1.68734878
28MP0003718_maternal_effect1.66173102
29MP0006036_abnormal_mitochondrial_physio1.63829500
30MP0006292_abnormal_olfactory_placode1.61835124
31MP0008057_abnormal_DNA_replication1.61023186
32MP0001697_abnormal_embryo_size1.59408039
33MP0004147_increased_porphyrin_level1.58451213
34MP0005380_embryogenesis_phenotype1.54861927
35MP0001672_abnormal_embryogenesis/_devel1.54861927
36MP0002080_prenatal_lethality1.52933764
37MP0004808_abnormal_hematopoietic_stem1.52246274
38MP0002085_abnormal_embryonic_tissue1.51057260
39MP0000703_abnormal_thymus_morphology1.49911614
40MP0004197_abnormal_fetal_growth/weight/1.47584244
41MP0002009_preneoplasia1.47114308
42MP0002398_abnormal_bone_marrow1.46765573
43MP0002837_dystrophic_cardiac_calcinosis1.45606283
44MP0003984_embryonic_growth_retardation1.45108654
45MP0004084_abnormal_cardiac_muscle1.44212434
46MP0003806_abnormal_nucleotide_metabolis1.44107921
47MP0000427_abnormal_hair_cycle1.42020373
48MP0002088_abnormal_embryonic_growth/wei1.40687455
49MP0002822_catalepsy1.35114118
50MP0001800_abnormal_humoral_immune1.34555685
51MP0003186_abnormal_redox_activity1.31582088
52MP0000569_abnormal_digit_pigmentation1.30338490
53MP0010307_abnormal_tumor_latency1.30114534
54MP0004043_abnormal_pH_regulation1.28471600
55MP0009046_muscle_twitch1.24827167
56MP0005253_abnormal_eye_physiology1.24380708
57MP0009278_abnormal_bone_marrow1.22363408
58MP0003763_abnormal_thymus_physiology1.20551503
59MP0002722_abnormal_immune_system1.17517071
60MP0003303_peritoneal_inflammation1.17479284
61MP0000689_abnormal_spleen_morphology1.17330096
62MP0000537_abnormal_urethra_morphology1.16993112
63MP0000313_abnormal_cell_death1.16896481
64MP0003890_abnormal_embryonic-extraembry1.16529137
65MP0003937_abnormal_limbs/digits/tail_de1.15366619
66MP0001661_extended_life_span1.15249197
67MP0002086_abnormal_extraembryonic_tissu1.14790654
68MP0005551_abnormal_eye_electrophysiolog1.14671341
69MP0004811_abnormal_neuron_physiology1.11939561
70MP0004885_abnormal_endolymph1.10587076
71MP0002019_abnormal_tumor_incidence1.09128728
72MP0000733_abnormal_muscle_development1.08518543
73MP0002254_reproductive_system_inflammat1.07807458
74MP0002909_abnormal_adrenal_gland1.07135446
75MP0008932_abnormal_embryonic_tissue1.05608770
76MP0003635_abnormal_synaptic_transmissio1.04859198
77MP0002095_abnormal_skin_pigmentation1.04415656
78MP0002269_muscular_atrophy1.04083268
79MP0006054_spinal_hemorrhage1.03201596
80MP0002102_abnormal_ear_morphology1.01161416
81MP0000647_abnormal_sebaceous_gland1.00140022
82MP0000747_muscle_weakness0.99985625
83MP0003866_abnormal_defecation0.99365238
84MP0005379_endocrine/exocrine_gland_phen0.99067304
85MP0003861_abnormal_nervous_system0.98745030
86MP0002160_abnormal_reproductive_system0.98661883
87MP0003567_abnormal_fetal_cardiomyocyte0.97476692
88MP0003136_yellow_coat_color0.97464343
89MP0000716_abnormal_immune_system0.96953853
90MP0009672_abnormal_birth_weight0.96644965
91MP0005266_abnormal_metabolism0.96120270
92MP0005645_abnormal_hypothalamus_physiol0.95458426
93MP0005621_abnormal_cell_physiology0.93962157
94MP0002429_abnormal_blood_cell0.92898788
95MP0005384_cellular_phenotype0.92836177
96MP0000383_abnormal_hair_follicle0.91684982
97MP0003119_abnormal_digestive_system0.91578396
98MP0003221_abnormal_cardiomyocyte_apopto0.88865482
99MP0008569_lethality_at_weaning0.88500999
100MP0000685_abnormal_immune_system0.88113257
101MP0004742_abnormal_vestibular_system0.88099757
102MP0000372_irregular_coat_pigmentation0.87122826
103MP0000751_myopathy0.86913700
104MP0003786_premature_aging0.85221799
105MP0008770_decreased_survivor_rate0.84893667
106MP0002163_abnormal_gland_morphology0.83841254
107MP0000428_abnormal_craniofacial_morphol0.82911553
108MP0000490_abnormal_crypts_of0.82352194
109MP0009703_decreased_birth_body0.82256050
110MP0001145_abnormal_male_reproductive0.81403274
111MP0002938_white_spotting0.80242998
112MP0005499_abnormal_olfactory_system0.80165806
113MP0005394_taste/olfaction_phenotype0.80165806
114MP0001835_abnormal_antigen_presentation0.78697273
115MP0004264_abnormal_extraembryonic_tissu0.78686194
116MP0002063_abnormal_learning/memory/cond0.76995094
117MP0003879_abnormal_hair_cell0.76761514
118MP0001929_abnormal_gametogenesis0.76706731
119MP0008872_abnormal_physiological_respon0.76097259
120MP0003698_abnormal_male_reproductive0.75930772
121MP0003646_muscle_fatigue0.75904070
122MP0002420_abnormal_adaptive_immunity0.75685834
123MP0003950_abnormal_plasma_membrane0.75278742
124MP0004087_abnormal_muscle_fiber0.74995182
125MP0005623_abnormal_meninges_morphology0.74422179
126MP0002452_abnormal_antigen_presenting0.74125333
127MP0002152_abnormal_brain_morphology0.73664958
128MP0005646_abnormal_pituitary_gland0.73425663
129MP0001819_abnormal_immune_cell0.72494022
130MP0002210_abnormal_sex_determination0.72354521
131MP0005187_abnormal_penis_morphology0.71940673
132MP0001873_stomach_inflammation0.71716543
133MP0002090_abnormal_vision0.71495159
134MP0000358_abnormal_cell_content/0.70678126
135MP0001790_abnormal_immune_system0.68570930
136MP0005387_immune_system_phenotype0.68570930
137MP0002089_abnormal_postnatal_growth/wei0.68447577
138MP0000955_abnormal_spinal_cord0.67786482
139MP0010630_abnormal_cardiac_muscle0.67640173
140MP0000653_abnormal_sex_gland0.66865403
141MP0005389_reproductive_system_phenotype0.66020859
142MP0010678_abnormal_skin_adnexa0.65749666
143MP0001727_abnormal_embryo_implantation0.65704364
144MP0001764_abnormal_homeostasis0.64881480
145MP0008775_abnormal_heart_ventricle0.63573947
146MP0001293_anophthalmia0.62288751
147MP0001968_abnormal_touch/_nociception0.61898216
148MP0009745_abnormal_behavioral_response0.61878389
149MP0005332_abnormal_amino_acid0.59731184
150MP0005391_vision/eye_phenotype0.58920480
151MP0000371_diluted_coat_color0.58548519
152MP0002272_abnormal_nervous_system0.57972119
153MP0002229_neurodegeneration0.57826685
154MP0001919_abnormal_reproductive_system0.57144952
155MP0002064_seizures0.56086854

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.49960400
2Abnormality of alanine metabolism (HP:0010916)4.49960400
3Hyperalaninemia (HP:0003348)4.49960400
4Birth length less than 3rd percentile (HP:0003561)4.41306895
5Ependymoma (HP:0002888)4.09678714
6Chromsome breakage (HP:0040012)4.01349698
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.78671702
8Hyperacusis (HP:0010780)3.38930662
9Abnormality of the astrocytes (HP:0100707)3.37381584
10Astrocytoma (HP:0009592)3.37381584
11Papilloma (HP:0012740)3.23271870
12Verrucae (HP:0200043)3.23271870
13Agammaglobulinemia (HP:0004432)3.17669611
14Abnormality of the labia minora (HP:0012880)3.06545272
15Abnormality of the lower motor neuron (HP:0002366)2.93360435
16Molar tooth sign on MRI (HP:0002419)2.84362431
17Abnormality of midbrain morphology (HP:0002418)2.84362431
18Increased nuchal translucency (HP:0010880)2.70862920
19Vertebral arch anomaly (HP:0008438)2.70829146
20Abnormality of chromosome stability (HP:0003220)2.70014663
21Medulloblastoma (HP:0002885)2.66829568
22Pointed chin (HP:0000307)2.61127347
23B lymphocytopenia (HP:0010976)2.60955409
24Abnormality of B cell number (HP:0010975)2.60955409
25Increased serum lactate (HP:0002151)2.59977119
26Abnormality of the ileum (HP:0001549)2.57054227
27Progressive inability to walk (HP:0002505)2.56963587
28Meckel diverticulum (HP:0002245)2.56495226
29Basal cell carcinoma (HP:0002671)2.54319623
30Congenital stationary night blindness (HP:0007642)2.54162087
31Protruding tongue (HP:0010808)2.50199919
32Glioma (HP:0009733)2.49365698
33Recurrent bronchitis (HP:0002837)2.49200227
34Pancreatic cysts (HP:0001737)2.44145099
35Neoplasm of the oral cavity (HP:0100649)2.43254620
36Partial agenesis of the corpus callosum (HP:0001338)2.41608730
37Poor head control (HP:0002421)2.40921538
38Pelvic girdle muscle weakness (HP:0003749)2.40882341
39Volvulus (HP:0002580)2.40191987
40Abnormality of the carotid arteries (HP:0005344)2.38689801
41Abnormality of the preputium (HP:0100587)2.37519361
42Acute necrotizing encephalopathy (HP:0006965)2.37498423
43Increased CSF lactate (HP:0002490)2.36304283
44Abnormality of the pons (HP:0007361)2.35975007
45Renal cortical cysts (HP:0000803)2.33691988
46Abnormality of glycolysis (HP:0004366)2.33507897
47Resting tremor (HP:0002322)2.31305032
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.31237440
49Abnormality of the renal cortex (HP:0011035)2.30666989
50Hypoplasia of the pons (HP:0012110)2.29089285
51Sloping forehead (HP:0000340)2.28253993
52Elfin facies (HP:0004428)2.27630695
53Increased serum pyruvate (HP:0003542)2.27282419
54Heterotopia (HP:0002282)2.27037098
55Cellulitis (HP:0100658)2.26661360
56Multiple enchondromatosis (HP:0005701)2.23602165
57Patellar aplasia (HP:0006443)2.20916410
58Shoulder girdle muscle weakness (HP:0003547)2.20871452
59Ketoacidosis (HP:0001993)2.20707897
60Acute encephalopathy (HP:0006846)2.19526947
61Colon cancer (HP:0003003)2.16522560
62Colitis (HP:0002583)2.14613620
63Progressive muscle weakness (HP:0003323)2.13676849
64Abnormal mitochondria in muscle tissue (HP:0008316)2.12777100
65Small epiphyses (HP:0010585)2.10407779
66Renal duplication (HP:0000075)2.10308606
67Panhypogammaglobulinemia (HP:0003139)2.10058309
68Pancreatic fibrosis (HP:0100732)2.09168688
69Abnormality of the fingertips (HP:0001211)2.08538516
70Abnormal number of erythroid precursors (HP:0012131)2.08416003
71Oligodactyly (hands) (HP:0001180)2.08154649
72Urinary urgency (HP:0000012)2.07979786
73Cerebral hypomyelination (HP:0006808)2.07623061
74Agnosia (HP:0010524)2.07072869
75Short chin (HP:0000331)2.06829800
76Recurrent viral infections (HP:0004429)2.06514280
77Pheochromocytoma (HP:0002666)2.06056028
78Neuroendocrine neoplasm (HP:0100634)2.05766042
79Amyotrophic lateral sclerosis (HP:0007354)2.05748378
80Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05145277
81Aplasia/Hypoplasia of the patella (HP:0006498)2.03737661
82Abnormality of cells of the erythroid lineage (HP:0012130)2.03353285
83Abnormality of the hip-girdle musculature (HP:0001445)2.03298192
84Abnormality of the musculature of the pelvis (HP:0001469)2.03298192
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02567742
86Short 4th metacarpal (HP:0010044)2.02567742
87Posterior subcapsular cataract (HP:0007787)2.01879314
88Fair hair (HP:0002286)2.01581872
89Broad palm (HP:0001169)2.01169349
90Microvesicular hepatic steatosis (HP:0001414)2.00521087
91Abnormality of serum amino acid levels (HP:0003112)1.98655715
92Microretrognathia (HP:0000308)1.96563385
93Nephronophthisis (HP:0000090)1.96520232
94Lactic acidosis (HP:0003128)1.95592157
95Dysmetric saccades (HP:0000641)1.93626448
96Concave nail (HP:0001598)1.91948562
97Thyroiditis (HP:0100646)1.91844569
98Inability to walk (HP:0002540)1.91379936
99Progressive microcephaly (HP:0000253)1.91271522
100Ventricular fibrillation (HP:0001663)1.90712225
101Overriding aorta (HP:0002623)1.88783609
102Brittle hair (HP:0002299)1.88105990
103Hand muscle atrophy (HP:0009130)1.87001059
104Progressive macrocephaly (HP:0004481)1.86717231
105Carpal bone hypoplasia (HP:0001498)1.86097811
106Neoplasm of the heart (HP:0100544)1.86066177
107T lymphocytopenia (HP:0005403)1.85843585
108Lipid accumulation in hepatocytes (HP:0006561)1.85428079
109Mitochondrial inheritance (HP:0001427)1.83801289
110Proximal placement of thumb (HP:0009623)1.83562096
111Cafe-au-lait spot (HP:0000957)1.82646909
112Angiofibromas (HP:0010615)1.82444845
113Adenoma sebaceum (HP:0009720)1.82444845
114Cerebral edema (HP:0002181)1.82014146
115Insomnia (HP:0100785)1.81776193
116Trigonocephaly (HP:0000243)1.79906368
117Lissencephaly (HP:0001339)1.79765268
118Gastrointestinal inflammation (HP:0004386)1.79053521
119Chronic hepatic failure (HP:0100626)1.77744698
120Abnormality of the intervertebral disk (HP:0005108)1.77571346
121Prominent nose (HP:0000448)1.77468621
122Aplasia involving forearm bones (HP:0009822)1.76971187
123Absent forearm bone (HP:0003953)1.76971187
124Biliary tract neoplasm (HP:0100574)1.76735706
125Abnormality of homocysteine metabolism (HP:0010919)1.76147298
126Homocystinuria (HP:0002156)1.76147298
127Gastrointestinal carcinoma (HP:0002672)1.75990130
128Malignant gastrointestinal tract tumors (HP:0006749)1.75990130
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.75967422
130Abnormality of the renal medulla (HP:0100957)1.75754582
131IgM deficiency (HP:0002850)1.75751357
132Renovascular hypertension (HP:0100817)1.75486421
133CNS hypomyelination (HP:0003429)1.74985098
134Cutis marmorata (HP:0000965)1.74474908
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74017997
136Abnormal protein N-linked glycosylation (HP:0012347)1.74017997
137Abnormal protein glycosylation (HP:0012346)1.74017997
138Abnormal glycosylation (HP:0012345)1.74017997
139Impaired vibration sensation in the lower limbs (HP:0002166)1.73774632
140Absent radius (HP:0003974)1.73575671
141Attention deficit hyperactivity disorder (HP:0007018)1.72803629
142Acute lymphatic leukemia (HP:0006721)1.72748024
143Broad-based gait (HP:0002136)1.72583929
144Combined immunodeficiency (HP:0005387)1.70902440
145Urinary bladder sphincter dysfunction (HP:0002839)1.70576627
146Clubbing of toes (HP:0100760)1.70419013
147Enlarged penis (HP:0000040)1.69778725
148Horseshoe kidney (HP:0000085)1.69700266
149Ectopic kidney (HP:0000086)1.68699671
150Postnatal microcephaly (HP:0005484)1.68129178
151Cortical dysplasia (HP:0002539)1.67911276
152Neoplasm of striated muscle (HP:0009728)1.67464289
153Hypomagnesemia (HP:0002917)1.67212123
154Abnormal number of incisors (HP:0011064)1.67170351
155Neoplasm of the adrenal cortex (HP:0100641)1.67098318
156Upper limb amyotrophy (HP:0009129)1.66833813
157Distal upper limb amyotrophy (HP:0007149)1.66833813
158Pendular nystagmus (HP:0012043)1.66690274
159Hepatic necrosis (HP:0002605)1.66678731
160Attenuation of retinal blood vessels (HP:0007843)1.65832532
161Obsessive-compulsive behavior (HP:0000722)1.65785486
162Type II lissencephaly (HP:0007260)1.65686508
163Generalized hypotonia (HP:0001290)1.65528206
164Small hand (HP:0200055)1.65350402
165Megalocornea (HP:0000485)1.64881319
166Long eyelashes (HP:0000527)1.63972186
167Ankle clonus (HP:0011448)1.63149206
168Neoplasm of the adrenal gland (HP:0100631)1.62719177
169Cerebellar dysplasia (HP:0007033)1.62391333
170Gastrointestinal stroma tumor (HP:0100723)1.62226082
171Myokymia (HP:0002411)1.62140974
172Abnormality of T cell number (HP:0011839)1.61645179
173Deviation of the thumb (HP:0009603)1.61573986
174Degeneration of anterior horn cells (HP:0002398)1.61309091
175Abnormality of the anterior horn cell (HP:0006802)1.61309091
176Flattened epiphyses (HP:0003071)1.61218634
177Optic disc pallor (HP:0000543)1.61207237
178Skin tags (HP:0010609)1.61167088
179Facial hemangioma (HP:0000329)1.60294757
180Inflammation of the large intestine (HP:0002037)1.60256859
181Sacral dimple (HP:0000960)1.60170816
182True hermaphroditism (HP:0010459)1.59849476
183Selective tooth agenesis (HP:0001592)1.59303806
184Tubular atrophy (HP:0000092)1.59291415
185Aplasia/Hypoplasia of the sternum (HP:0006714)1.59143906
186Large for gestational age (HP:0001520)1.59105797
187Annular pancreas (HP:0001734)1.58791438
188Abnormality of the 4th metacarpal (HP:0010012)1.58529183
189Small intestinal stenosis (HP:0012848)1.58257031
190Duodenal stenosis (HP:0100867)1.58257031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.00294985
2NEK13.82081156
3EEF2K3.60649755
4FRK3.50588639
5TSSK63.21520914
6MKNK23.01226066
7PKN22.89507588
8CDK122.79398413
9TRIB32.38469461
10ZAK2.27755894
11MAP4K12.21040604
12ALK2.11933839
13NEK22.10847681
14BMPR1B1.98062021
15ACVR1B1.96072840
16PLK41.88637580
17RPS6KB21.86944472
18CDC71.85920939
19SIK21.83303625
20BUB11.81746646
21MAP3K91.80111940
22EIF2AK31.79732757
23ADRBK21.77290829
24BRSK21.74958772
25WNK41.71475499
26TESK21.68606122
27GRK61.65851400
28MAP4K21.54256877
29NUAK11.51303716
30SIK31.50851171
31MST41.44542218
32KSR11.43220267
33KSR21.35901049
34PDK41.34479061
35PDK31.34479061
36BRD41.29064325
37LRRK21.28031874
38SCYL21.24623788
39WEE11.24303413
40STK101.20977991
41CDK41.16298181
42CSF1R1.15406588
43PNCK1.11373281
44NME11.08888098
45PBK1.08670070
46CHEK11.05510184
47MARK11.04723661
48ICK1.04635580
49PAK41.04320107
50TGFBR10.99747410
51TRIM280.98686409
52TTK0.96065122
53BRSK10.95177470
54ATR0.94200294
55PAK60.93165468
56ERN10.93138001
57TYRO30.91233612
58PLK30.90444286
59PLK20.90269249
60DAPK10.89817491
61PINK10.87321519
62STK30.87054513
63MTOR0.84337525
64STK160.83448858
65CDK20.81872411
66PASK0.80375303
67EPHA20.79387793
68CCNB10.79351536
69PDK20.78103996
70TESK10.77827030
71TAF10.76254506
72PRKD30.75623858
73ERBB30.75573634
74TRPM70.74805653
75CAMKK10.74342128
76PLK10.73753612
77MAP3K80.73410494
78MAPKAPK30.71804658
79MINK10.71647696
80SYK0.71052468
81MARK30.70877418
82TAOK10.69691353
83CSNK1A1L0.68667038
84MAP3K40.67436639
85INSRR0.67329980
86CDK60.67314144
87CSNK1G10.66581732
88EIF2AK20.65010655
89GRK10.64582986
90MAP3K70.62138719
91DYRK1B0.61427319
92EIF2AK10.61165227
93CSNK2A20.61157673
94MAPKAPK50.60601291
95WNK30.59343431
96CAMKK20.59328466
97CDC42BPA0.56894170
98OXSR10.56765943
99CHEK20.56578710
100PRKCH0.56569616
101CDK70.56381329
102SRPK10.56063265
103SIK10.55249244
104CDK180.54851593
105CDK80.54625303
106CSNK1D0.53382042
107CDK150.53250713
108RIPK10.52611749
109AURKB0.52522758
110CDK10.52480681
111PTK60.52371978
112RET0.51991732
113DYRK30.51519325
114PRKCI0.51333060
115CDK11A0.51266699
116FGFR10.51060283
117CSNK1G30.50534322
118CSNK2A10.49751417
119PDGFRA0.49552770
120CSNK1E0.48825830
121STK380.47373739
122CAMK1G0.47248517
123STK390.47123085
124NME20.46795644
125RPS6KA50.46625242
126TTN0.46329045
127CAMK1D0.44761390
128MAPK110.44569713
129CDK140.43688312
130NTRK30.43589720
131CLK10.43439103
132CSNK1G20.42508801
133IRAK30.42352353
134PAK30.41675336
135RPS6KA40.41417506
136FGFR30.40891140
137MARK20.40521564
138VRK20.38711867
139GSK3B0.37826204
140CDK30.37723746
141FGFR40.37156796
142PRKDC0.36954949
143TLK10.36475537
144ATM0.36157051
145MKNK10.36002014
146VRK10.35986610
147TNIK0.35677400
148MAPK140.35035602
149MAPK80.34649949
150AURKA0.34481489
151PDK10.34048795
152MAPK100.33536479
153AKT30.32839706
154PHKG20.31685366
155PHKG10.31685366

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.81663916
2Spliceosome_Homo sapiens_hsa030402.45718198
3RNA transport_Homo sapiens_hsa030132.31959440
4Basal transcription factors_Homo sapiens_hsa030222.15780146
5Mismatch repair_Homo sapiens_hsa034302.11210946
6Primary immunodeficiency_Homo sapiens_hsa053402.08901446
7Protein export_Homo sapiens_hsa030602.06312727
8B cell receptor signaling pathway_Homo sapiens_hsa046621.96247734
9mRNA surveillance pathway_Homo sapiens_hsa030151.95221933
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90909089
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83889202
12DNA replication_Homo sapiens_hsa030301.82716292
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.80793974
14Pyrimidine metabolism_Homo sapiens_hsa002401.80725585
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78917427
16Base excision repair_Homo sapiens_hsa034101.77328261
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75609314
18mTOR signaling pathway_Homo sapiens_hsa041501.70058309
19Cell cycle_Homo sapiens_hsa041101.55441182
20Synaptic vesicle cycle_Homo sapiens_hsa047211.51330908
21Propanoate metabolism_Homo sapiens_hsa006401.49749311
22Oocyte meiosis_Homo sapiens_hsa041141.48449733
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45931395
24Butanoate metabolism_Homo sapiens_hsa006501.45297765
25Colorectal cancer_Homo sapiens_hsa052101.42809148
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40616196
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40082816
28Purine metabolism_Homo sapiens_hsa002301.37503563
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35275862
30Epstein-Barr virus infection_Homo sapiens_hsa051691.34723525
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33699874
32Vitamin B6 metabolism_Homo sapiens_hsa007501.33225558
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31422396
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31302383
35Antigen processing and presentation_Homo sapiens_hsa046121.26797285
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22568007
37Ribosome_Homo sapiens_hsa030101.21930190
38Non-small cell lung cancer_Homo sapiens_hsa052231.21784862
39Pyruvate metabolism_Homo sapiens_hsa006201.21144593
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19399071
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19200946
42Chronic myeloid leukemia_Homo sapiens_hsa052201.19128465
43Oxidative phosphorylation_Homo sapiens_hsa001901.18726303
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17621927
45Non-homologous end-joining_Homo sapiens_hsa034501.13323806
46Olfactory transduction_Homo sapiens_hsa047401.12494670
47Lysine degradation_Homo sapiens_hsa003101.11389754
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.11300819
49Nucleotide excision repair_Homo sapiens_hsa034201.09343970
50Endometrial cancer_Homo sapiens_hsa052131.08442781
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.05297917
52Parkinsons disease_Homo sapiens_hsa050121.05181357
53T cell receptor signaling pathway_Homo sapiens_hsa046601.04955874
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04922095
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04788892
56Viral carcinogenesis_Homo sapiens_hsa052031.04741627
57Notch signaling pathway_Homo sapiens_hsa043301.04589295
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01103903
59Huntingtons disease_Homo sapiens_hsa050161.00660816
60Phototransduction_Homo sapiens_hsa047440.99990331
61Nitrogen metabolism_Homo sapiens_hsa009100.95836915
62Glioma_Homo sapiens_hsa052140.94206630
63Biosynthesis of amino acids_Homo sapiens_hsa012300.94025645
64Long-term potentiation_Homo sapiens_hsa047200.93117216
65RNA degradation_Homo sapiens_hsa030180.93037484
66HTLV-I infection_Homo sapiens_hsa051660.89593483
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88715756
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87591338
69Steroid biosynthesis_Homo sapiens_hsa001000.84540764
70VEGF signaling pathway_Homo sapiens_hsa043700.83926477
71Dopaminergic synapse_Homo sapiens_hsa047280.82864393
72Estrogen signaling pathway_Homo sapiens_hsa049150.82583326
73Sulfur metabolism_Homo sapiens_hsa009200.80374632
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80265229
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79773563
76HIF-1 signaling pathway_Homo sapiens_hsa040660.78553872
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78407898
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78229972
79Endocytosis_Homo sapiens_hsa041440.77263021
80Insulin signaling pathway_Homo sapiens_hsa049100.76972215
81RNA polymerase_Homo sapiens_hsa030200.76366725
82Oxytocin signaling pathway_Homo sapiens_hsa049210.76096171
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75529518
84Type II diabetes mellitus_Homo sapiens_hsa049300.75124139
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73643888
86Pancreatic cancer_Homo sapiens_hsa052120.70809868
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69633241
88ErbB signaling pathway_Homo sapiens_hsa040120.69583769
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69378916
90Acute myeloid leukemia_Homo sapiens_hsa052210.68901070
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68541984
92Pentose phosphate pathway_Homo sapiens_hsa000300.67702617
93Renal cell carcinoma_Homo sapiens_hsa052110.67567683
94Proteasome_Homo sapiens_hsa030500.67545112
95Circadian entrainment_Homo sapiens_hsa047130.67400457
96Alcoholism_Homo sapiens_hsa050340.66142426
97Hippo signaling pathway_Homo sapiens_hsa043900.66012855
98Morphine addiction_Homo sapiens_hsa050320.65745339
99MicroRNAs in cancer_Homo sapiens_hsa052060.65464813
100Amphetamine addiction_Homo sapiens_hsa050310.64892338
101Glucagon signaling pathway_Homo sapiens_hsa049220.64297578
102Tryptophan metabolism_Homo sapiens_hsa003800.64226558
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63811585
104p53 signaling pathway_Homo sapiens_hsa041150.63330929
105Inositol phosphate metabolism_Homo sapiens_hsa005620.62588626
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.62400323
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62389583
108Folate biosynthesis_Homo sapiens_hsa007900.61725401
109FoxO signaling pathway_Homo sapiens_hsa040680.59981107
110Cholinergic synapse_Homo sapiens_hsa047250.59914385
111Gastric acid secretion_Homo sapiens_hsa049710.59841440
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59098357
113Ether lipid metabolism_Homo sapiens_hsa005650.57975665
114Gap junction_Homo sapiens_hsa045400.57677747
115Fatty acid metabolism_Homo sapiens_hsa012120.57655992
116Carbon metabolism_Homo sapiens_hsa012000.57538863
117Fanconi anemia pathway_Homo sapiens_hsa034600.57350398
118Shigellosis_Homo sapiens_hsa051310.56923517
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56706526
120Fatty acid elongation_Homo sapiens_hsa000620.55636193
121Herpes simplex infection_Homo sapiens_hsa051680.55509841
122Viral myocarditis_Homo sapiens_hsa054160.55464095
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54998524
124Hepatitis B_Homo sapiens_hsa051610.54830590
125MAPK signaling pathway_Homo sapiens_hsa040100.54244278
126Metabolic pathways_Homo sapiens_hsa011000.53775920
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53257047
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53166626
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53027108
130Small cell lung cancer_Homo sapiens_hsa052220.52103862
131Alzheimers disease_Homo sapiens_hsa050100.51899861
132Thyroid cancer_Homo sapiens_hsa052160.51762853
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51597845
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.51591502
135Homologous recombination_Homo sapiens_hsa034400.51494589
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.51173787
137One carbon pool by folate_Homo sapiens_hsa006700.51005026
138GABAergic synapse_Homo sapiens_hsa047270.50642807
139GnRH signaling pathway_Homo sapiens_hsa049120.50401697
140AMPK signaling pathway_Homo sapiens_hsa041520.50352921
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49840927
142Proteoglycans in cancer_Homo sapiens_hsa052050.49274330
143Sulfur relay system_Homo sapiens_hsa041220.44836030
144Arginine and proline metabolism_Homo sapiens_hsa003300.44716824
145Nicotine addiction_Homo sapiens_hsa050330.43128402
146Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42004065
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37414980
148Linoleic acid metabolism_Homo sapiens_hsa005910.35266601
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35078422
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31942028
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31255630
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31114497
153Regulation of autophagy_Homo sapiens_hsa041400.28959679
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.25716897
155Cardiac muscle contraction_Homo sapiens_hsa042600.24204115
156Fatty acid biosynthesis_Homo sapiens_hsa000610.23711408
157Taste transduction_Homo sapiens_hsa047420.22579402
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21820976
159Peroxisome_Homo sapiens_hsa041460.20997965
160N-Glycan biosynthesis_Homo sapiens_hsa005100.18014410
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.16967666
162Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16497320
163Glutathione metabolism_Homo sapiens_hsa004800.16248971
164Legionellosis_Homo sapiens_hsa051340.13619648
165Thyroid hormone synthesis_Homo sapiens_hsa049180.13457159
166beta-Alanine metabolism_Homo sapiens_hsa004100.12443223
167Fatty acid degradation_Homo sapiens_hsa000710.12392110
168Insulin secretion_Homo sapiens_hsa049110.11834317
169Mineral absorption_Homo sapiens_hsa049780.11746043
170Collecting duct acid secretion_Homo sapiens_hsa049660.11698841

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