DNAJC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.04180746
2ATP synthesis coupled proton transport (GO:0015986)5.07326108
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.07326108
4formation of translation preinitiation complex (GO:0001731)4.64607892
5DNA deamination (GO:0045006)4.56390790
6chaperone-mediated protein transport (GO:0072321)4.55911725
7telomere maintenance via semi-conservative replication (GO:0032201)4.48024732
8DNA strand elongation involved in DNA replication (GO:0006271)4.32256815
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.30433249
10viral transcription (GO:0019083)4.25553161
11regulation of mitochondrial translation (GO:0070129)4.23534818
12ribosomal small subunit biogenesis (GO:0042274)4.22063744
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.20138275
14respiratory electron transport chain (GO:0022904)4.20131744
15translational termination (GO:0006415)4.14796513
16maturation of SSU-rRNA (GO:0030490)4.10266152
17electron transport chain (GO:0022900)4.07722131
18DNA strand elongation (GO:0022616)4.07203348
19telomere maintenance via recombination (GO:0000722)4.03504729
20establishment of viral latency (GO:0019043)3.99253656
21proteasome assembly (GO:0043248)3.96720224
22ribosomal small subunit assembly (GO:0000028)3.93791910
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.84815861
24translational initiation (GO:0006413)3.83799716
25viral mRNA export from host cell nucleus (GO:0046784)3.81808109
26replication fork processing (GO:0031297)3.81455182
27ribosomal large subunit biogenesis (GO:0042273)3.79905800
28mitotic recombination (GO:0006312)3.70030509
29purine nucleobase biosynthetic process (GO:0009113)3.69754074
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.69743776
31oxidative phosphorylation (GO:0006119)3.67760506
32translational elongation (GO:0006414)3.66443429
33rRNA modification (GO:0000154)3.63240913
34regulation of cellular amino acid metabolic process (GO:0006521)3.62242686
35ribonucleoprotein complex biogenesis (GO:0022613)3.62099973
36DNA replication initiation (GO:0006270)3.57943549
37kinetochore organization (GO:0051383)3.56384331
38mitotic sister chromatid segregation (GO:0000070)3.55867258
39protein neddylation (GO:0045116)3.55568621
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.54982347
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.54982347
42kinetochore assembly (GO:0051382)3.53227528
43maturation of 5.8S rRNA (GO:0000460)3.51105939
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50598804
45positive regulation of ligase activity (GO:0051351)3.49552176
46protein targeting to mitochondrion (GO:0006626)3.49417660
47rRNA processing (GO:0006364)3.48691202
48DNA damage response, detection of DNA damage (GO:0042769)3.48347625
49cullin deneddylation (GO:0010388)3.47627112
50establishment of integrated proviral latency (GO:0075713)3.47058640
51histone exchange (GO:0043486)3.46800735
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45745744
53protein complex biogenesis (GO:0070271)3.44926790
54telomere maintenance via telomere lengthening (GO:0010833)3.44903816
55nucleobase biosynthetic process (GO:0046112)3.44829408
56cotranslational protein targeting to membrane (GO:0006613)3.44412183
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42940033
58DNA replication checkpoint (GO:0000076)3.42217819
59transcription-coupled nucleotide-excision repair (GO:0006283)3.41655797
60DNA replication-independent nucleosome assembly (GO:0006336)3.41257132
61DNA replication-independent nucleosome organization (GO:0034724)3.41257132
62mitochondrial respiratory chain complex assembly (GO:0033108)3.40891064
63protein targeting to ER (GO:0045047)3.39801829
64spliceosomal snRNP assembly (GO:0000387)3.37962597
65ribosome biogenesis (GO:0042254)3.37831355
66mitotic metaphase plate congression (GO:0007080)3.36600860
67rRNA metabolic process (GO:0016072)3.35987894
68cellular protein complex disassembly (GO:0043624)3.33916340
69regulation of ubiquitin-protein transferase activity (GO:0051438)3.33845003
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31853008
71viral life cycle (GO:0019058)3.31798107
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31301920
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.31301920
74NADH dehydrogenase complex assembly (GO:0010257)3.31301920
75establishment of protein localization to mitochondrion (GO:0072655)3.29880809
76protein localization to mitochondrion (GO:0070585)3.28565640
77protein deneddylation (GO:0000338)3.25599125
78transcription from mitochondrial promoter (GO:0006390)3.25509561
79positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24757695
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.22660048
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22292768
82nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22288748
83regulation of ligase activity (GO:0051340)3.22109803
84negative regulation of ligase activity (GO:0051352)3.21334354
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21334354
86protein localization to endoplasmic reticulum (GO:0070972)3.19430063
87metaphase plate congression (GO:0051310)3.19120783
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19056497
89spliceosomal complex assembly (GO:0000245)3.18692851
90CENP-A containing nucleosome assembly (GO:0034080)3.18509274
91protein localization to chromosome, centromeric region (GO:0071459)3.18452184
92chromatin remodeling at centromere (GO:0031055)3.16615399
93DNA unwinding involved in DNA replication (GO:0006268)3.15026978
94meiotic chromosome segregation (GO:0045132)3.14515570
95DNA replication-dependent nucleosome organization (GO:0034723)3.14144267
96DNA replication-dependent nucleosome assembly (GO:0006335)3.14144267
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14024050
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14024050
99termination of RNA polymerase II transcription (GO:0006369)3.13253185
100termination of RNA polymerase III transcription (GO:0006386)3.12141006
101transcription elongation from RNA polymerase III promoter (GO:0006385)3.12141006
102signal transduction involved in DNA damage checkpoint (GO:0072422)3.11153789
103signal transduction involved in DNA integrity checkpoint (GO:0072401)3.11153789
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10636519
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10636519
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10636519
107positive regulation of chromosome segregation (GO:0051984)3.10350605
108regulation of double-strand break repair via homologous recombination (GO:0010569)3.10231149
109cellular component biogenesis (GO:0044085)3.09772822
110histone mRNA metabolic process (GO:0008334)3.09076989
111protein localization to kinetochore (GO:0034501)3.08930021
112translation (GO:0006412)3.08189506
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07200659
114signal transduction involved in cell cycle checkpoint (GO:0072395)3.06557012
115pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06307131
116DNA ligation (GO:0006266)3.06021172
117pseudouridine synthesis (GO:0001522)3.03164191
118attachment of spindle microtubules to kinetochore (GO:0008608)3.00404980
119DNA double-strand break processing (GO:0000729)3.00347700
120ribosome assembly (GO:0042255)2.99747225
121protein complex disassembly (GO:0043241)2.96733683
122G1/S transition of mitotic cell cycle (GO:0000082)2.96055050
123cell cycle G1/S phase transition (GO:0044843)2.96055050
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95378675
125double-strand break repair via nonhomologous end joining (GO:0006303)2.95217266
126non-recombinational repair (GO:0000726)2.95217266
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.94617532
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94617532
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94617532
130sister chromatid segregation (GO:0000819)2.93389567
131nuclear-transcribed mRNA catabolic process (GO:0000956)2.91303627
132base-excision repair (GO:0006284)2.91151498
133* RNA splicing, via transesterification reactions (GO:0000375)2.89758645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.67470089
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51988557
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57880412
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.48636447
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42457428
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.36471281
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34387516
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.26156662
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24513914
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17280501
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.14081944
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95384926
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94895294
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92416538
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.89202815
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73429779
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71256648
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42731966
19VDR_23849224_ChIP-Seq_CD4+_Human2.39655714
20XRN2_22483619_ChIP-Seq_HELA_Human2.39075172
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36726480
22DCP1A_22483619_ChIP-Seq_HELA_Human2.27320018
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23594697
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21715402
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17237458
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12008769
27TTF2_22483619_ChIP-Seq_HELA_Human2.04468992
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02785637
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00290834
30GABP_19822575_ChIP-Seq_HepG2_Human1.94319922
31FOXP3_21729870_ChIP-Seq_TREG_Human1.90552059
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89970111
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89688240
34ELK1_19687146_ChIP-ChIP_HELA_Human1.88065025
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87244005
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.85440131
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84053470
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.81117473
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75008201
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74680750
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74680750
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74680750
43* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70718441
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63222055
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.63045597
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62861280
47* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56990759
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56798060
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.55991409
50* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53553770
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48640441
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44679568
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44513041
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44346104
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42882787
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42390008
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.41601644
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41331696
59AR_21909140_ChIP-Seq_LNCAP_Human1.41126596
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40619428
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39261254
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37547402
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31079059
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28055053
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26662022
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25779517
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25084322
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20979196
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.20746516
70* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20395523
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20311567
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19407463
73CIITA_25753668_ChIP-Seq_RAJI_Human1.17102335
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15400911
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.14506029
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13181265
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11600068
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07125924
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06961199
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06848998
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.06725612
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06230446
83EWS_26573619_Chip-Seq_HEK293_Human1.05845994
84* TFEB_21752829_ChIP-Seq_HELA_Human1.05156057
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03897785
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03032237
87MYC_18940864_ChIP-ChIP_HL60_Human1.02978617
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02855989
89* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02765559
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.02091797
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02077041
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00237341
93SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99508882
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.99172570
95TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98529351
96SALL1_21062744_ChIP-ChIP_HESCs_Human0.98155951
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97369240
98* NANOG_16153702_ChIP-ChIP_HESCs_Human0.97359235
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95044917
100* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94022072
101VDR_21846776_ChIP-Seq_THP-1_Human0.91874923
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91872140
103CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91752045
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90195297
105SPI1_23547873_ChIP-Seq_NB4_Human0.88465026
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88080336
107POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88074556
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.86965911
109MYC_22102868_ChIP-Seq_BL_Human0.86829162
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.86418160
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85561187
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85352438
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79623869
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77132703
115VDR_22108803_ChIP-Seq_LS180_Human0.76016017
116ZNF274_21170338_ChIP-Seq_K562_Hela0.75902298
117IRF1_19129219_ChIP-ChIP_H3396_Human0.74716385
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74015794
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73334986
120FUS_26573619_Chip-Seq_HEK293_Human0.73082099
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69438569
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68867863
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.67410667
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64989416
125* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64141174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.18652150
2MP0004957_abnormal_blastocyst_morpholog4.39690753
3MP0003693_abnormal_embryo_hatching4.38544087
4MP0010094_abnormal_chromosome_stability4.16143242
5MP0003111_abnormal_nucleus_morphology3.58500625
6MP0003077_abnormal_cell_cycle3.46374004
7MP0008058_abnormal_DNA_repair3.10174843
8MP0008932_abnormal_embryonic_tissue2.89612995
9MP0008877_abnormal_DNA_methylation2.73004096
10MP0003806_abnormal_nucleotide_metabolis2.53603540
11MP0003186_abnormal_redox_activity2.43269925
12MP0009697_abnormal_copulation2.29536881
13MP0003786_premature_aging2.25712377
14MP0008007_abnormal_cellular_replicative2.23947544
15MP0004147_increased_porphyrin_level2.21408036
16MP0006035_abnormal_mitochondrial_morpho2.19782796
17MP0010030_abnormal_orbit_morphology2.06445483
18MP0002102_abnormal_ear_morphology2.04245034
19MP0001730_embryonic_growth_arrest1.97363782
20MP0000350_abnormal_cell_proliferation1.94886425
21MP0003718_maternal_effect1.94076955
22MP0003123_paternal_imprinting1.89034183
23MP0000372_irregular_coat_pigmentation1.87133706
24MP0008789_abnormal_olfactory_epithelium1.84085796
25MP0005171_absent_coat_pigmentation1.81592668
26MP0001697_abnormal_embryo_size1.72690285
27MP0003136_yellow_coat_color1.65902046
28MP0004133_heterotaxia1.65395340
29MP0006072_abnormal_retinal_apoptosis1.58722109
30MP0002085_abnormal_embryonic_tissue1.51631047
31MP0009278_abnormal_bone_marrow1.49394352
32MP0005084_abnormal_gallbladder_morpholo1.48302284
33MP0002084_abnormal_developmental_patter1.43949645
34MP0001672_abnormal_embryogenesis/_devel1.41432227
35MP0005380_embryogenesis_phenotype1.41432227
36MP0005394_taste/olfaction_phenotype1.41045535
37MP0005499_abnormal_olfactory_system1.41045535
38MP0009333_abnormal_splenocyte_physiolog1.40669027
39MP0000490_abnormal_crypts_of1.38237568
40MP0003890_abnormal_embryonic-extraembry1.37126023
41MP0003567_abnormal_fetal_cardiomyocyte1.36705297
42MP0002080_prenatal_lethality1.35562557
43MP0000313_abnormal_cell_death1.31833648
44MP0006292_abnormal_olfactory_placode1.27548054
45MP0002019_abnormal_tumor_incidence1.25382833
46MP0002009_preneoplasia1.25108945
47MP0002086_abnormal_extraembryonic_tissu1.24469509
48MP0003011_delayed_dark_adaptation1.22324523
49MP0003121_genomic_imprinting1.21401961
50MP0005397_hematopoietic_system_phenotyp1.18834797
51MP0001545_abnormal_hematopoietic_system1.18834797
52MP0003984_embryonic_growth_retardation1.17997951
53MP0001529_abnormal_vocalization1.14368142
54MP0002653_abnormal_ependyma_morphology1.14261254
55MP0010352_gastrointestinal_tract_polyps1.13784058
56MP0002088_abnormal_embryonic_growth/wei1.12095404
57MP0001293_anophthalmia1.11689664
58MP0005075_abnormal_melanosome_morpholog1.11340279
59MP0003315_abnormal_perineum_morphology1.08449908
60MP0008995_early_reproductive_senescence1.08074738
61MP0010307_abnormal_tumor_latency1.06419980
62MP0002736_abnormal_nociception_after1.05647758
63MP0002396_abnormal_hematopoietic_system1.05290599
64MP0000015_abnormal_ear_pigmentation1.03806222
65MP0002210_abnormal_sex_determination1.03355886
66MP0004197_abnormal_fetal_growth/weight/1.03262066
67MP0005253_abnormal_eye_physiology1.02779476
68MP0009379_abnormal_foot_pigmentation1.01315624
69MP0000703_abnormal_thymus_morphology1.00451954
70MP0001764_abnormal_homeostasis0.99737695
71MP0001145_abnormal_male_reproductive0.98853317
72MP0001188_hyperpigmentation0.96916836
73MP0005174_abnormal_tail_pigmentation0.96758433
74MP0004233_abnormal_muscle_weight0.96736424
75MP0003119_abnormal_digestive_system0.96509655
76MP0005408_hypopigmentation0.94750914
77MP0000631_abnormal_neuroendocrine_gland0.94630623
78MP0002398_abnormal_bone_marrow0.93498592
79MP0003763_abnormal_thymus_physiology0.92003832
80MP0002638_abnormal_pupillary_reflex0.88516596
81MP0002163_abnormal_gland_morphology0.87951506
82MP0002722_abnormal_immune_system0.86720489
83MP0002234_abnormal_pharynx_morphology0.86480337
84MP0000689_abnormal_spleen_morphology0.86421550
85MP0001929_abnormal_gametogenesis0.84383828
86MP0000653_abnormal_sex_gland0.83993403
87MP0002090_abnormal_vision0.83112409
88MP0002233_abnormal_nose_morphology0.83062060
89MP0009672_abnormal_birth_weight0.80790306
90MP0002111_abnormal_tail_morphology0.79107241
91MP0003941_abnormal_skin_development0.79076844
92MP0002697_abnormal_eye_size0.78609906
93MP0005391_vision/eye_phenotype0.78200627
94MP0003122_maternal_imprinting0.77825164
95MP0000358_abnormal_cell_content/0.77264782
96MP0002751_abnormal_autonomic_nervous0.75317553
97MP0002405_respiratory_system_inflammati0.75209595
98MP0001727_abnormal_embryo_implantation0.73582130
99MP0003880_abnormal_central_pattern0.72979529
100MP0003698_abnormal_male_reproductive0.72959250
101MP0002282_abnormal_trachea_morphology0.72729898
102MP0004142_abnormal_muscle_tone0.72291532
103MP0003938_abnormal_ear_development0.72189108
104MP0003787_abnormal_imprinting0.70501736
105MP0002837_dystrophic_cardiac_calcinosis0.69277163
106MP0000647_abnormal_sebaceous_gland0.69242412
107MP0002938_white_spotting0.69023400
108MP0005645_abnormal_hypothalamus_physiol0.68798715
109MP0002429_abnormal_blood_cell0.68415955
110MP0005389_reproductive_system_phenotype0.68051427
111MP0002277_abnormal_respiratory_mucosa0.67590485
112MP0003221_abnormal_cardiomyocyte_apopto0.65862952
113MP0003448_altered_tumor_morphology0.65834123
114MP0001984_abnormal_olfaction0.65585670
115MP0003937_abnormal_limbs/digits/tail_de0.64896298
116MP0002114_abnormal_axial_skeleton0.64462687
117MP0001485_abnormal_pinna_reflex0.64017552
118MP0001119_abnormal_female_reproductive0.62617450
119MP0000470_abnormal_stomach_morphology0.62366664
120MP0004808_abnormal_hematopoietic_stem0.61843570
121MP0002249_abnormal_larynx_morphology0.61763522
122MP0001881_abnormal_mammary_gland0.60878132
123MP0003283_abnormal_digestive_organ0.60444025
124MP0002095_abnormal_skin_pigmentation0.60368588
125MP0002132_abnormal_respiratory_system0.60282534
126MP0004742_abnormal_vestibular_system0.60128684
127MP0000716_abnormal_immune_system0.59630832
128MP0002160_abnormal_reproductive_system0.59492017
129MP0001905_abnormal_dopamine_level0.59270265
130MP0003755_abnormal_palate_morphology0.58584230
131MP0005384_cellular_phenotype0.58333863
132MP0006036_abnormal_mitochondrial_physio0.58227763
133MP0005671_abnormal_response_to0.58078064
134MP0001286_abnormal_eye_development0.56675604
135MP0001919_abnormal_reproductive_system0.56507911
136MP0000049_abnormal_middle_ear0.55216456
137MP0005266_abnormal_metabolism0.55173090
138MP0003861_abnormal_nervous_system0.54721754
139MP0001186_pigmentation_phenotype0.53643459
140MP0003936_abnormal_reproductive_system0.53331981

Predicted human phenotypes

RankGene SetZ-score
1Acute encephalopathy (HP:0006846)4.81933100
2Birth length less than 3rd percentile (HP:0003561)4.15903855
3Abnormality of cells of the erythroid lineage (HP:0012130)4.12195671
4Lipid accumulation in hepatocytes (HP:0006561)3.98664691
5Reticulocytopenia (HP:0001896)3.78263846
6Hepatic necrosis (HP:0002605)3.74394772
7Cerebral edema (HP:0002181)3.73557043
8Abnormal number of erythroid precursors (HP:0012131)3.65803148
9Breast hypoplasia (HP:0003187)3.60656957
10Absent radius (HP:0003974)3.55614796
11Cerebral hypomyelination (HP:0006808)3.53764543
12Patellar aplasia (HP:0006443)3.47872316
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.43679287
14Renal Fanconi syndrome (HP:0001994)3.39738802
15Absent forearm bone (HP:0003953)3.36623740
16Aplasia involving forearm bones (HP:0009822)3.36623740
17Rib fusion (HP:0000902)3.35029293
18Aplasia/Hypoplasia of the patella (HP:0006498)3.25638469
19Abnormality of the labia minora (HP:0012880)3.23962848
20Absent thumb (HP:0009777)3.19560813
21Rectovaginal fistula (HP:0000143)3.16059308
22Rectal fistula (HP:0100590)3.16059308
23Microvesicular hepatic steatosis (HP:0001414)3.15958386
243-Methylglutaconic aciduria (HP:0003535)3.00377766
25Increased serum lactate (HP:0002151)2.99599980
26Increased intramyocellular lipid droplets (HP:0012240)2.92178662
27Lactic acidosis (HP:0003128)2.91366374
28Facial hemangioma (HP:0000329)2.87258870
29Exertional dyspnea (HP:0002875)2.80813791
30Premature graying of hair (HP:0002216)2.78496668
31Macrocytic anemia (HP:0001972)2.77446145
32Respiratory failure (HP:0002878)2.73435313
33Exercise intolerance (HP:0003546)2.71939535
34Abnormality of the ileum (HP:0001549)2.69779626
35Aplasia/hypoplasia of the humerus (HP:0006507)2.68999904
36Selective tooth agenesis (HP:0001592)2.67811465
37Concave nail (HP:0001598)2.64705254
38Carpal bone hypoplasia (HP:0001498)2.64450992
39Leukodystrophy (HP:0002415)2.61527723
40Supernumerary spleens (HP:0009799)2.60576019
41Chromsome breakage (HP:0040012)2.59681627
42Acute necrotizing encephalopathy (HP:0006965)2.58284262
43Abnormal hemoglobin (HP:0011902)2.58084918
44Intestinal fistula (HP:0100819)2.55653839
45Agnosia (HP:0010524)2.54035469
46Pallor (HP:0000980)2.53745963
47Type I transferrin isoform profile (HP:0003642)2.52500918
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51071657
49Optic disc pallor (HP:0000543)2.45678233
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42894170
51Vaginal fistula (HP:0004320)2.40693064
52Rough bone trabeculation (HP:0100670)2.40389284
53Increased hepatocellular lipid droplets (HP:0006565)2.39890713
54Pancytopenia (HP:0001876)2.39538733
55Oral leukoplakia (HP:0002745)2.39280727
56Aplastic anemia (HP:0001915)2.38908283
57Respiratory difficulties (HP:0002880)2.38806496
58Hypoplasia of the radius (HP:0002984)2.38492118
59Meckel diverticulum (HP:0002245)2.38056836
60Multiple enchondromatosis (HP:0005701)2.38028173
61Methylmalonic acidemia (HP:0002912)2.37982765
62Abnormality of the anterior horn cell (HP:0006802)2.36838514
63Degeneration of anterior horn cells (HP:0002398)2.36838514
64Abnormality of methionine metabolism (HP:0010901)2.35654896
65Mitochondrial inheritance (HP:0001427)2.33113259
66Abnormal number of incisors (HP:0011064)2.32042422
67Increased muscle lipid content (HP:0009058)2.30790200
68Tongue fasciculations (HP:0001308)2.29209898
69Increased IgM level (HP:0003496)2.28995160
70Abnormality of the preputium (HP:0100587)2.28553778
71Methylmalonic aciduria (HP:0012120)2.26233183
72Trismus (HP:0000211)2.20025207
73Short humerus (HP:0005792)2.19353067
74Basal cell carcinoma (HP:0002671)2.19309269
75Colon cancer (HP:0003003)2.17972632
76Abnormal mitochondria in muscle tissue (HP:0008316)2.17327386
77Stenosis of the external auditory canal (HP:0000402)2.16639159
78Premature ovarian failure (HP:0008209)2.16131409
79Myelodysplasia (HP:0002863)2.15538288
80Lethargy (HP:0001254)2.14902407
81Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10333377
82Abnormality of chromosome stability (HP:0003220)2.09941222
83Orthostatic hypotension (HP:0001278)2.07632529
84Squamous cell carcinoma (HP:0002860)2.07629778
85CNS demyelination (HP:0007305)2.07456842
86Muscle fiber atrophy (HP:0100295)2.07428935
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.07276299
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06993616
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06993616
90Poikiloderma (HP:0001029)2.06615273
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06185841
92Increased CSF lactate (HP:0002490)2.04804294
93Abnormality of abdominal situs (HP:0011620)2.03308540
94Abdominal situs inversus (HP:0003363)2.03308540
95Type 2 muscle fiber atrophy (HP:0003554)2.03216189
96Short thumb (HP:0009778)2.03182950
97Asplenia (HP:0001746)2.03181669
98Nephroblastoma (Wilms tumor) (HP:0002667)2.02519903
99CNS hypomyelination (HP:0003429)2.01801388
100Duplicated collecting system (HP:0000081)2.01563648
101Muscle fibrillation (HP:0010546)2.01322235
102Aplasia/Hypoplasia involving the musculature (HP:0001460)2.01312078
103Medulloblastoma (HP:0002885)2.00974583
104Intestinal atresia (HP:0011100)1.99869474
105Megaloblastic anemia (HP:0001889)1.97486350
106Abnormality of renal resorption (HP:0011038)1.95836530
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93600670
108Abnormal protein glycosylation (HP:0012346)1.92882086
109Abnormal glycosylation (HP:0012345)1.92882086
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92882086
111Abnormal protein N-linked glycosylation (HP:0012347)1.92882086
112Progressive macrocephaly (HP:0004481)1.92862018
113X-linked dominant inheritance (HP:0001423)1.91538653
114Generalized aminoaciduria (HP:0002909)1.90036815
115Embryonal renal neoplasm (HP:0011794)1.89562602
116Triphalangeal thumb (HP:0001199)1.88300209
117Emotional lability (HP:0000712)1.86607803
118Amniotic constriction ring (HP:0009775)1.86184922
119Abnormality of placental membranes (HP:0011409)1.86184922
120Ependymoma (HP:0002888)1.83773006
121Hepatocellular necrosis (HP:0001404)1.83505489
122Pustule (HP:0200039)1.82892405
123Volvulus (HP:0002580)1.82874454
124Cleft eyelid (HP:0000625)1.82749056
125Horseshoe kidney (HP:0000085)1.82593303
126Hyperglycinemia (HP:0002154)1.82418438
12711 pairs of ribs (HP:0000878)1.81898458
128Increased serum pyruvate (HP:0003542)1.81265960
129Abnormality of glycolysis (HP:0004366)1.81265960
130Hypoglycemic coma (HP:0001325)1.79516064
131Duodenal stenosis (HP:0100867)1.79515665
132Small intestinal stenosis (HP:0012848)1.79515665
133Septo-optic dysplasia (HP:0100842)1.78517267
134Abnormal lung lobation (HP:0002101)1.78512323
135Reduced antithrombin III activity (HP:0001976)1.78206409
136Bone marrow hypocellularity (HP:0005528)1.77675885
137Cellular immunodeficiency (HP:0005374)1.77167113
138Congenital, generalized hypertrichosis (HP:0004540)1.77003564
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.76865951
140Cortical dysplasia (HP:0002539)1.74881169
141Absent septum pellucidum (HP:0001331)1.74340475
142Abnormality of the duodenum (HP:0002246)1.72709441
143Neoplasm of the colon (HP:0100273)1.69705341
144Abnormality of serum amino acid levels (HP:0003112)1.67360569
145Poor head control (HP:0002421)1.65824997
146Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65387803
147Dicarboxylic aciduria (HP:0003215)1.65387803
148Nausea (HP:0002018)1.65387762
149Homocystinuria (HP:0002156)1.65141810
150Abnormality of homocysteine metabolism (HP:0010919)1.65141810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.55857054
2BUB14.45721860
3WEE13.59785398
4CDC73.26814363
5EIF2AK12.84100772
6STK162.65025066
7SRPK12.47595915
8NME22.31272387
9TESK22.06174412
10TSSK61.99051561
11PIM21.96965036
12VRK11.95172576
13ZAK1.93087321
14PLK11.89579416
15MAP3K61.88590497
16MKNK11.88103162
17PLK41.87236605
18NUAK11.86214553
19FGR1.75930867
20MST41.74192048
21TLK11.72150216
22MAP3K111.71426340
23TTK1.70657259
24CDK71.69578185
25TRIM281.65544051
26NEK21.63489053
27MKNK21.55618005
28ICK1.51553810
29EIF2AK31.51370673
30NEK11.48653798
31DDR21.48627401
32RPS6KB21.46971032
33CHEK21.41507162
34BRSK21.41320898
35PBK1.40230936
36DYRK31.39462908
37AURKB1.39292825
38PNCK1.36241069
39BCKDK1.34640786
40AURKA1.31294249
41PLK31.29206915
42DAPK11.27523309
43ACVR1B1.26628330
44MAP4K21.23469260
45UHMK11.20725033
46ATR1.19063784
47MAPK151.17679612
48PIM11.13841811
49PLK21.11409964
50YES11.09600405
51TAF11.08933281
52WNK31.07723582
53CDK191.06625931
54STK101.04555231
55MATK1.04431368
56DYRK21.00907921
57NME11.00300592
58CHEK10.98254056
59MAP3K80.95916541
60STK40.90266796
61EIF2AK20.89866555
62CSNK2A10.87153392
63PDK20.86867971
64CSNK1G20.86450950
65EPHA20.84485344
66TYRO30.84340734
67AKT30.83338660
68SCYL20.81476235
69CSNK2A20.80992111
70PAK10.78547146
71BRSK10.78314918
72ARAF0.78272049
73MAP3K120.76581433
74CDK80.76009031
75CDK20.74738353
76TRPM70.74716341
77PINK10.74603700
78PAK40.72344343
79BMPR1B0.72212583
80MAP2K70.71598868
81CSNK1A1L0.71151294
82LATS20.70037527
83ATM0.68730270
84RPS6KA50.66833777
85CSK0.66466817
86TNIK0.66406486
87BRAF0.63327193
88MAPKAPK30.62090454
89TESK10.60479874
90KDR0.59636110
91CDK60.59507964
92DYRK1B0.59187083
93PASK0.57255047
94PRKCI0.57226864
95MAPKAPK50.55477092
96CDK10.54804775
97LIMK10.54465408
98CLK10.53796091
99CDK40.53116590
100CDK30.52226722
101RPS6KC10.51445034
102RPS6KL10.51445034
103CCNB10.50948555
104ERBB30.50027141
105BMX0.48052825
106CSNK1G30.46485495
107CDK11A0.46168522
108STK30.46135847
109MINK10.45571838
110RAF10.44516667
111RPS6KA60.44300283
112RPS6KA40.43981811
113CSNK1G10.43731317
114ALK0.41743640
115CDK150.41222227
116ILK0.40948332
117CDK180.40140431
118CDK140.40024039
119CDK120.39322309
120MAP4K10.38187741
121CSNK1E0.37536035
122LYN0.37294422
123BCR0.35461474
124MAP3K40.34711660
125TAOK20.34192776
126PRKCG0.33776692
127PRKDC0.31428386
128STK38L0.29624960
129CSNK1A10.27114141
130ADRBK20.23032040
131PRKACB0.21239802
132LRRK20.20248946

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.38901517
2DNA replication_Homo sapiens_hsa030304.28681348
3Ribosome_Homo sapiens_hsa030104.08332353
4Proteasome_Homo sapiens_hsa030503.95525106
5RNA polymerase_Homo sapiens_hsa030203.44625071
6Spliceosome_Homo sapiens_hsa030403.36411397
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32165766
8Base excision repair_Homo sapiens_hsa034103.05123752
9Nucleotide excision repair_Homo sapiens_hsa034202.90913562
10Homologous recombination_Homo sapiens_hsa034402.86012781
11RNA transport_Homo sapiens_hsa030132.77113440
12Cell cycle_Homo sapiens_hsa041102.18918350
13Fanconi anemia pathway_Homo sapiens_hsa034602.09331233
14Pyrimidine metabolism_Homo sapiens_hsa002402.05890740
15Basal transcription factors_Homo sapiens_hsa030222.01681659
16Oxidative phosphorylation_Homo sapiens_hsa001901.95972957
17Parkinsons disease_Homo sapiens_hsa050121.85066456
18RNA degradation_Homo sapiens_hsa030181.83003379
19mRNA surveillance pathway_Homo sapiens_hsa030151.75294839
20Non-homologous end-joining_Homo sapiens_hsa034501.74037772
21Huntingtons disease_Homo sapiens_hsa050161.63107821
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61186591
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42450884
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41683197
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37781665
26p53 signaling pathway_Homo sapiens_hsa041151.37111611
27One carbon pool by folate_Homo sapiens_hsa006701.32012933
28Fatty acid elongation_Homo sapiens_hsa000621.25922544
29Pyruvate metabolism_Homo sapiens_hsa006201.24879978
30Epstein-Barr virus infection_Homo sapiens_hsa051691.24823417
31Propanoate metabolism_Homo sapiens_hsa006401.24231075
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18835289
33Protein export_Homo sapiens_hsa030601.17871002
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16033518
35Alzheimers disease_Homo sapiens_hsa050101.12164141
36Purine metabolism_Homo sapiens_hsa002301.11962133
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06672058
38Oocyte meiosis_Homo sapiens_hsa041141.04803085
39Selenocompound metabolism_Homo sapiens_hsa004501.03983284
40Steroid biosynthesis_Homo sapiens_hsa001000.92981977
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91035810
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87572865
43Carbon metabolism_Homo sapiens_hsa012000.84295772
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83766128
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83382470
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80777255
47Systemic lupus erythematosus_Homo sapiens_hsa053220.79431423
48Viral carcinogenesis_Homo sapiens_hsa052030.76439070
49Primary immunodeficiency_Homo sapiens_hsa053400.74890117
50Shigellosis_Homo sapiens_hsa051310.71855153
51Herpes simplex infection_Homo sapiens_hsa051680.69938759
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69637290
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68062491
54Butanoate metabolism_Homo sapiens_hsa006500.66568262
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66109164
56Antigen processing and presentation_Homo sapiens_hsa046120.61469745
57Sulfur metabolism_Homo sapiens_hsa009200.61227960
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57295895
59Hippo signaling pathway_Homo sapiens_hsa043900.56113084
60TGF-beta signaling pathway_Homo sapiens_hsa043500.54536707
61Hedgehog signaling pathway_Homo sapiens_hsa043400.50593461
62HTLV-I infection_Homo sapiens_hsa051660.49701207
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49697619
64Cardiac muscle contraction_Homo sapiens_hsa042600.48904696
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48191048
66Peroxisome_Homo sapiens_hsa041460.47899134
67Legionellosis_Homo sapiens_hsa051340.47868943
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47474687
69Allograft rejection_Homo sapiens_hsa053300.47265510
70Notch signaling pathway_Homo sapiens_hsa043300.46950546
71Graft-versus-host disease_Homo sapiens_hsa053320.46622276
72Alcoholism_Homo sapiens_hsa050340.44665295
73N-Glycan biosynthesis_Homo sapiens_hsa005100.44413405
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41848875
75Colorectal cancer_Homo sapiens_hsa052100.39966780
76Regulation of autophagy_Homo sapiens_hsa041400.39903625
77Phototransduction_Homo sapiens_hsa047440.39131021
78Asthma_Homo sapiens_hsa053100.38826552
79Wnt signaling pathway_Homo sapiens_hsa043100.38173161
80Autoimmune thyroid disease_Homo sapiens_hsa053200.35482734
81Measles_Homo sapiens_hsa051620.34993762
82MicroRNAs in cancer_Homo sapiens_hsa052060.34694562
83Folate biosynthesis_Homo sapiens_hsa007900.34086679
84Collecting duct acid secretion_Homo sapiens_hsa049660.33638856
85Adherens junction_Homo sapiens_hsa045200.32894209
86Viral myocarditis_Homo sapiens_hsa054160.32268674
87Fatty acid metabolism_Homo sapiens_hsa012120.31895635
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30766324
89Glutathione metabolism_Homo sapiens_hsa004800.26279757
90Tight junction_Homo sapiens_hsa045300.25801833
91Arachidonic acid metabolism_Homo sapiens_hsa005900.25663088
92Thyroid cancer_Homo sapiens_hsa052160.24774886
93Basal cell carcinoma_Homo sapiens_hsa052170.24685111
94Biosynthesis of amino acids_Homo sapiens_hsa012300.24653774
95Hepatitis B_Homo sapiens_hsa051610.24639772
96Apoptosis_Homo sapiens_hsa042100.23438779
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.22744314
98Pathways in cancer_Homo sapiens_hsa052000.21739462
99Hematopoietic cell lineage_Homo sapiens_hsa046400.21708179
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21389860
101Pentose phosphate pathway_Homo sapiens_hsa000300.21123401
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20878833
103Small cell lung cancer_Homo sapiens_hsa052220.20446736
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19958889
105Tryptophan metabolism_Homo sapiens_hsa003800.19407738
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.19234344
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19135706
108Vitamin B6 metabolism_Homo sapiens_hsa007500.18994970
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18677921
110Sulfur relay system_Homo sapiens_hsa041220.17425023
111Type I diabetes mellitus_Homo sapiens_hsa049400.17396831
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17072009
113Rheumatoid arthritis_Homo sapiens_hsa053230.16848990
114Vibrio cholerae infection_Homo sapiens_hsa051100.16438196
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16431308
116Phagosome_Homo sapiens_hsa041450.16408986
117Nitrogen metabolism_Homo sapiens_hsa009100.15838056
118Fructose and mannose metabolism_Homo sapiens_hsa000510.15777639
119Bladder cancer_Homo sapiens_hsa052190.15708664
120mTOR signaling pathway_Homo sapiens_hsa041500.15422370
121Metabolic pathways_Homo sapiens_hsa011000.14800369
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14798682
123HIF-1 signaling pathway_Homo sapiens_hsa040660.14475142
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13624360
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.12904551
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12838319
127Salmonella infection_Homo sapiens_hsa051320.12519393
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12454585
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.11609309
130Arginine and proline metabolism_Homo sapiens_hsa003300.10891203
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10523696
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.08336041
133Tyrosine metabolism_Homo sapiens_hsa003500.06800632
134Vitamin digestion and absorption_Homo sapiens_hsa049770.06209869
135beta-Alanine metabolism_Homo sapiens_hsa004100.03931434
136Fatty acid degradation_Homo sapiens_hsa000710.03874152
137Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0359854
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0276204
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980-0.0061245

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