ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sequestering of actin monomers (GO:0042989)	7.55520303
2	cytidine metabolic process (GO:0046087)	7.44201747
3	cytidine catabolic process (GO:0006216)	7.44201747
4	cytidine deamination (GO:0009972)	7.44201747
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.55298280
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.48171500
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.41548400
8	DNA deamination (GO:0045006)	6.33668615
9	ATP synthesis coupled proton transport (GO:0015986)	5.94807579
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.94807579
11	protein neddylation (GO:0045116)	5.65966394
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.04663265
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.75641423
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.75641423
15	platelet dense granule organization (GO:0060155)	4.53916924
16	respiratory electron transport chain (GO:0022904)	4.47785743
17	electron transport chain (GO:0022900)	4.38095694
18	proteasome assembly (GO:0043248)	4.16115040
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.95000310
20	DNA double-strand break processing (GO:0000729)	3.78682219
21	regulation of cellular amino acid metabolic process (GO:0006521)	3.77149318
22	oxidative phosphorylation (GO:0006119)	3.75386307
23	iron-sulfur cluster assembly (GO:0016226)	3.68844516
24	metallo-sulfur cluster assembly (GO:0031163)	3.68844516
25	mannosylation (GO:0097502)	3.68770556
26	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.67940068
27	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.64233645
28	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.40717066
29	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.36697392
30	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.28345315
31	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.28345315
32	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.28345315
33	rRNA modification (GO:0000154)	3.24991732
34	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.24807468
35	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.24807468
36	ATP biosynthetic process (GO:0006754)	3.21995814
37	negative regulation of ligase activity (GO:0051352)	3.20335560
38	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.20335560
39	negative regulation by host of viral transcription (GO:0043922)	3.19919907
40	cullin deneddylation (GO:0010388)	3.18315036
41	T cell migration (GO:0072678)	3.17792101
42	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.15398070
43	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.14552985
44	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.13933924
45	positive regulation of calcium-mediated signaling (GO:0050850)	3.11968316
46	actin nucleation (GO:0045010)	3.10821738
47	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.10025596
48	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.10025596
49	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.09375059
50	hydrogen ion transmembrane transport (GO:1902600)	3.05407437
51	protein deneddylation (GO:0000338)	3.03722033
52	DNA damage response, detection of DNA damage (GO:0042769)	3.00184799
53	eosinophil chemotaxis (GO:0048245)	2.97416904
54	aldehyde catabolic process (GO:0046185)	2.90775328
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.89511364
56	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.89347423
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.88092719
58	proton transport (GO:0015992)	2.87681782
59	termination of RNA polymerase III transcription (GO:0006386)	2.86452571
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.86452571
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86196856
62	chaperone-mediated protein transport (GO:0072321)	2.85718340
63	positive regulation of interleukin-8 secretion (GO:2000484)	2.84463406
64	epithelial cilium movement (GO:0003351)	2.83616766
65	positive regulation of TOR signaling (GO:0032008)	2.81897331
66	rRNA methylation (GO:0031167)	2.81883096
67	positive regulation of prostaglandin secretion (GO:0032308)	2.81001623
68	hydrogen transport (GO:0006818)	2.80252175
69	inner mitochondrial membrane organization (GO:0007007)	2.79783214
70	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.76371168
71	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.76371168
72	NADH dehydrogenase complex assembly (GO:0010257)	2.76371168
73	ribosomal small subunit assembly (GO:0000028)	2.73070033
74	protein complex biogenesis (GO:0070271)	2.72522346
75	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.72075174
76	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71957785
77	interferon-gamma production (GO:0032609)	2.69994729
78	eosinophil migration (GO:0072677)	2.69469723
79	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.68201670
80	sterol catabolic process (GO:0016127)	2.66593856
81	cholesterol catabolic process (GO:0006707)	2.66593856
82	cytolysis (GO:0019835)	2.66451238
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66172732
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.66172732
85	protein-cofactor linkage (GO:0018065)	2.66107198
86	pyrimidine nucleoside catabolic process (GO:0046135)	2.65063452
87	aerobic respiration (GO:0009060)	2.64240210
88	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.64228024
89	regulation of cellular amine metabolic process (GO:0033238)	2.63086117
90	behavioral response to nicotine (GO:0035095)	2.62227585
91	positive regulation of cell cycle arrest (GO:0071158)	2.61483206
92	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.59965420
93	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.58976467
94	positive regulation of ligase activity (GO:0051351)	2.58815288
95	kynurenine metabolic process (GO:0070189)	2.57873316
96	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.55366785
97	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.55181837
98	signal peptide processing (GO:0006465)	2.54090005
99	pseudouridine synthesis (GO:0001522)	2.53649755
100	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.53198606

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.00028389
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.90557891
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.54858743
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.35783278
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.13250708
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.90343049
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.47000861
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.35699872
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.75859776
10	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.73448353
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69617982
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.54639993
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44508757
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41712908
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.30428180
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20597261
17	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.12683552
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.08299005
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.05995813
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.03057103
21	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.98350841
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96554426
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.85532540
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.83974423
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.79632127
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67099633
27	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.59430529
28	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.58907969
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.55738158
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.50800587
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.46129709
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.45000314
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.44508429
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.44356293
35	GATA1_22025678_ChIP-Seq_K562_Human	1.43528119
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.42487708
37	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.39915921
38	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.35932896
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35138097
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34789646
41	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.32752634
42	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31891520
43	VDR_22108803_ChIP-Seq_LS180_Human	1.30227489
44	EWS_26573619_Chip-Seq_HEK293_Human	1.29031142
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.28716927
46	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27656013
47	AR_20517297_ChIP-Seq_VCAP_Human	1.27165218
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25689624
49	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25254225
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.24932195
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24838751
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.24391772
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.23873601
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.22261255
55	XRN2_22483619_ChIP-Seq_HELA_Human	1.22214278
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19375809
57	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.16847515
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16692786
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16692786
60	CIITA_25753668_ChIP-Seq_RAJI_Human	1.15592112
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15143593
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13470033
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.12685844
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12604544
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12602421
66	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.11817953
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.11008124
68	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.09043190
69	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08812442
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08667520
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08018201
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07129616
73	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06013292
74	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05870962
75	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05351073
76	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.04648658
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.04502373
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04330779
79	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04171626
80	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.02707318
81	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.01341252
82	FUS_26573619_Chip-Seq_HEK293_Human	0.99246201
83	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98750031
84	NCOR_22424771_ChIP-Seq_293T_Human	0.98561855
85	GATA3_26560356_Chip-Seq_TH2_Human	0.98560553
86	ERG_20517297_ChIP-Seq_VCAP_Human	0.96565803
87	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.94476081
88	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.93396749
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92504586
90	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.92209718
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92056250
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91537475
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91537475
94	MYB_26560356_Chip-Seq_TH2_Human	0.90559712
95	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.88723247
96	P300_19829295_ChIP-Seq_ESCs_Human	0.87713847
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87433855
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87360485
99	TAF15_26573619_Chip-Seq_HEK293_Human	0.87214086
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.86703808

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.06872532
2	MP0005645_abnormal_hypothalamus_physiol	4.02882259
3	MP0005671_abnormal_response_to	3.65337896
4	MP0003880_abnormal_central_pattern	3.58275959
5	MP0000372_irregular_coat_pigmentation	3.28569535
6	MP0008995_early_reproductive_senescence	2.98744886
7	MP0002254_reproductive_system_inflammat	2.67363835
8	MP0008789_abnormal_olfactory_epithelium	2.41906456
9	MP0005394_taste/olfaction_phenotype	2.35302423
10	MP0005499_abnormal_olfactory_system	2.35302423
11	MP0006276_abnormal_autonomic_nervous	2.27814843
12	MP0003786_premature_aging	2.15255976
13	MP0006072_abnormal_retinal_apoptosis	1.95309924
14	MP0009785_altered_susceptibility_to	1.92875274
15	MP0002166_altered_tumor_susceptibility	1.89639896
16	MP0001529_abnormal_vocalization	1.88077169
17	MP0009379_abnormal_foot_pigmentation	1.87904884
18	MP0003283_abnormal_digestive_organ	1.86592987
19	MP0009333_abnormal_splenocyte_physiolog	1.83619914
20	MP0003866_abnormal_defecation	1.83194568
21	MP0002234_abnormal_pharynx_morphology	1.66305952
22	MP0004145_abnormal_muscle_electrophysio	1.62844213
23	MP0003136_yellow_coat_color	1.60640626
24	MP0002006_tumorigenesis	1.57331841
25	MP0001968_abnormal_touch/_nociception	1.52942670
26	MP0002837_dystrophic_cardiac_calcinosis	1.51089647
27	MP0006036_abnormal_mitochondrial_physio	1.49691246
28	MP0003011_delayed_dark_adaptation	1.46444379
29	MP0002736_abnormal_nociception_after	1.45545497
30	MP0003763_abnormal_thymus_physiology	1.42362728
31	MP0001905_abnormal_dopamine_level	1.40508942
32	MP0005253_abnormal_eye_physiology	1.40485528
33	MP0004133_heterotaxia	1.31891435
34	MP0001984_abnormal_olfaction	1.28654744
35	MP0009697_abnormal_copulation	1.27888568
36	MP0005377_hearing/vestibular/ear_phenot	1.26837983
37	MP0003878_abnormal_ear_physiology	1.26837983
38	MP0003693_abnormal_embryo_hatching	1.25795211
39	MP0002751_abnormal_autonomic_nervous	1.23673080
40	MP0006082_CNS_inflammation	1.23527415
41	MP0005084_abnormal_gallbladder_morpholo	1.22665865
42	MP0005551_abnormal_eye_electrophysiolog	1.22596337
43	MP0001293_anophthalmia	1.19837366
44	MP0004957_abnormal_blastocyst_morpholog	1.17699206
45	MP0003787_abnormal_imprinting	1.16938253
46	MP0003137_abnormal_impulse_conducting	1.16174814
47	MP0009764_decreased_sensitivity_to	1.15757862
48	MP0004147_increased_porphyrin_level	1.13774569
49	MP0003045_fibrosis	1.11686363
50	MP0002938_white_spotting	1.09350400
51	MP0010386_abnormal_urinary_bladder	1.08380709
52	MP0002148_abnormal_hypersensitivity_rea	1.08162267
53	MP0003724_increased_susceptibility_to	1.08149262
54	MP0008872_abnormal_physiological_respon	1.08081878
55	MP0003806_abnormal_nucleotide_metabolis	1.07595751
56	MP0005379_endocrine/exocrine_gland_phen	1.07492182
57	MP0001485_abnormal_pinna_reflex	1.07136116
58	MP0002090_abnormal_vision	1.00803061
59	MP0000778_abnormal_nervous_system	1.00562755
60	MP0001800_abnormal_humoral_immune	0.99220829
61	MP0008932_abnormal_embryonic_tissue	0.98750529
62	MP0002277_abnormal_respiratory_mucosa	0.98314858
63	MP0003718_maternal_effect	0.97940918
64	MP0001790_abnormal_immune_system	0.97038197
65	MP0005387_immune_system_phenotype	0.97038197
66	MP0002723_abnormal_immune_serum	0.94815572
67	MP0004270_analgesia	0.94676818
68	MP0006035_abnormal_mitochondrial_morpho	0.92011189
69	MP0000631_abnormal_neuroendocrine_gland	0.91483855
70	MP0001835_abnormal_antigen_presentation	0.89725442
71	MP0002909_abnormal_adrenal_gland	0.88670185
72	MP0002876_abnormal_thyroid_physiology	0.88391590
73	MP0005075_abnormal_melanosome_morpholog	0.85544190
74	MP0003646_muscle_fatigue	0.85424339
75	MP0005000_abnormal_immune_tolerance	0.84312478
76	MP0002420_abnormal_adaptive_immunity	0.83493102
77	MP0002933_joint_inflammation	0.83166716
78	MP0005636_abnormal_mineral_homeostasis	0.81967535
79	MP0008877_abnormal_DNA_methylation	0.81967031
80	MP0000685_abnormal_immune_system	0.81249138
81	MP0001119_abnormal_female_reproductive	0.78000754
82	MP0001501_abnormal_sleep_pattern	0.77869619
83	MP0009745_abnormal_behavioral_response	0.77821785
84	MP0001819_abnormal_immune_cell	0.77155417
85	MP0002272_abnormal_nervous_system	0.76175596
86	MP0002067_abnormal_sensory_capabilities	0.75697309
87	MP0001727_abnormal_embryo_implantation	0.74626879
88	MP0005195_abnormal_posterior_eye	0.73121986
89	MP0005025_abnormal_response_to	0.72576133
90	MP0001970_abnormal_pain_threshold	0.70061883
91	MP0001986_abnormal_taste_sensitivity	0.69721224
92	MP0001764_abnormal_homeostasis	0.69506331
93	MP0001879_abnormal_lymphatic_vessel	0.68837381
94	MP0005332_abnormal_amino_acid	0.68205320
95	MP0002752_abnormal_somatic_nervous	0.65685626
96	MP0001324_abnormal_eye_pigmentation	0.65164051
97	MP0002734_abnormal_mechanical_nocicepti	0.65078612
98	MP0008058_abnormal_DNA_repair	0.64064870
99	MP0002733_abnormal_thermal_nociception	0.63662895
100	MP0008875_abnormal_xenobiotic_pharmacok	0.61285795

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.92879062
2	Acute necrotizing encephalopathy (HP:0006965)	4.83381892
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.43370318
4	Mitochondrial inheritance (HP:0001427)	4.09368504
5	Chronic hepatic failure (HP:0100626)	4.08812041
6	Acute encephalopathy (HP:0006846)	3.99563018
7	Progressive macrocephaly (HP:0004481)	3.94926960
8	Hepatocellular necrosis (HP:0001404)	3.81364615
9	3-Methylglutaconic aciduria (HP:0003535)	3.65631938
10	Hepatic necrosis (HP:0002605)	3.53968873
11	Increased CSF lactate (HP:0002490)	3.52089127
12	Increased hepatocellular lipid droplets (HP:0006565)	3.49222812
13	T lymphocytopenia (HP:0005403)	3.48740142
14	Severe combined immunodeficiency (HP:0004430)	3.38547398
15	Cerebral edema (HP:0002181)	3.27549686
16	Pancreatic cysts (HP:0001737)	3.16427696
17	Pancreatic fibrosis (HP:0100732)	3.10325402
18	True hermaphroditism (HP:0010459)	3.05376893
19	Lipid accumulation in hepatocytes (HP:0006561)	3.04327008
20	Abnormality of T cell number (HP:0011839)	3.03712409
21	Renal Fanconi syndrome (HP:0001994)	3.02115861
22	Neuroendocrine neoplasm (HP:0100634)	2.98856022
23	Renal cortical cysts (HP:0000803)	2.93606294
24	Increased intramyocellular lipid droplets (HP:0012240)	2.86133208
25	Abnormality of the labia minora (HP:0012880)	2.72768405
26	IgG deficiency (HP:0004315)	2.71783526
27	Abnormality of T cells (HP:0002843)	2.66032994
28	Combined immunodeficiency (HP:0005387)	2.65714279
29	Optic disc pallor (HP:0000543)	2.63907438
30	Stomatitis (HP:0010280)	2.62638360
31	Pancytopenia (HP:0001876)	2.60239691
32	Increased IgM level (HP:0003496)	2.53030653
33	Exertional dyspnea (HP:0002875)	2.52962994
34	Oral leukoplakia (HP:0002745)	2.50482115
35	Occipital encephalocele (HP:0002085)	2.46242515
36	Hyperglycinemia (HP:0002154)	2.46014901
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.43524141
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.43524141
39	Type I transferrin isoform profile (HP:0003642)	2.41826664
40	Colon cancer (HP:0003003)	2.41450418
41	Increased serum lactate (HP:0002151)	2.36155254
42	Intrahepatic cholestasis (HP:0001406)	2.32106161
43	Respiratory failure (HP:0002878)	2.28925248
44	Thyroid-stimulating hormone excess (HP:0002925)	2.26676770
45	Emotional lability (HP:0000712)	2.26575705
46	Generalized aminoaciduria (HP:0002909)	2.23836111
47	Increased muscle lipid content (HP:0009058)	2.23511772
48	Retinal dysplasia (HP:0007973)	2.20715927
49	IgM deficiency (HP:0002850)	2.17996963
50	Hypoproteinemia (HP:0003075)	2.17246118
51	Lactic acidosis (HP:0003128)	2.15412875
52	Microvesicular hepatic steatosis (HP:0001414)	2.14561546
53	Acute hepatic failure (HP:0006554)	2.13413693
54	Abnormality of the renal cortex (HP:0011035)	2.12590164
55	Chronic diarrhea (HP:0002028)	2.12081248
56	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.11991600
57	Rhinitis (HP:0012384)	2.08915698
58	Hypothermia (HP:0002045)	2.08685397
59	Exercise intolerance (HP:0003546)	2.08552091
60	Abnormality of the vocal cords (HP:0008777)	2.07373285
61	Abolished electroretinogram (ERG) (HP:0000550)	2.04211196
62	Thyroiditis (HP:0100646)	2.04011105
63	Congenital stationary night blindness (HP:0007642)	2.02622849
64	Cellular immunodeficiency (HP:0005374)	2.01069161
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00799083
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.00799083
67	Abnormal protein glycosylation (HP:0012346)	2.00799083
68	Abnormal glycosylation (HP:0012345)	2.00799083
69	Neonatal respiratory distress (HP:0002643)	2.00160011
70	Prostate neoplasm (HP:0100787)	1.99728193
71	Abnormal respiratory epithelium morphology (HP:0012253)	1.97240677
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97240677
73	Constricted visual fields (HP:0001133)	1.96652282
74	Molar tooth sign on MRI (HP:0002419)	1.94581586
75	Abnormality of midbrain morphology (HP:0002418)	1.94581586
76	Abnormality of serine family amino acid metabolism (HP:0010894)	1.94052371
77	Abnormality of glycine metabolism (HP:0010895)	1.94052371
78	Lethargy (HP:0001254)	1.93826749
79	Amyotrophic lateral sclerosis (HP:0007354)	1.92196800
80	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.91966624
81	Abnormality of eosinophils (HP:0001879)	1.91843547
82	Sclerocornea (HP:0000647)	1.91354648
83	Leukodystrophy (HP:0002415)	1.85424703
84	Abnormality of renal resorption (HP:0011038)	1.84119946
85	Meckel diverticulum (HP:0002245)	1.84076734
86	Medial flaring of the eyebrow (HP:0010747)	1.82561220
87	Tinnitus (HP:0000360)	1.82333141
88	Encephalitis (HP:0002383)	1.81990170
89	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.80876115
90	Congenital primary aphakia (HP:0007707)	1.80710693
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78148457
92	Anencephaly (HP:0002323)	1.75155001
93	Abnormality of the prostate (HP:0008775)	1.74621541
94	Vacuolated lymphocytes (HP:0001922)	1.73876345
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.73103936
96	Gait imbalance (HP:0002141)	1.72679555
97	Limb dystonia (HP:0002451)	1.70489715
98	CNS demyelination (HP:0007305)	1.70095901
99	Hyperglycinuria (HP:0003108)	1.69781543
100	Abnormality of the ileum (HP:0001549)	1.69636233

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.51924906
2	KDR	3.94975815
3	VRK2	3.82706659
4	TXK	3.79407143
5	ZAK	3.38963845
6	NUAK1	3.32927220
7	SRPK1	3.16134555
8	MAP4K2	2.99757794
9	VRK1	2.86949178
10	TESK1	2.74170009
11	LIMK1	2.35380898
12	TRIM28	2.21432433
13	TLK1	2.09621484
14	WNK4	2.05389669
15	BUB1	2.02072311
16	BCKDK	1.95608024
17	CDC7	1.88275701
18	BCR	1.71280193
19	MAP2K7	1.61708741
20	NME1	1.56607974
21	STK39	1.42529086
22	DAPK1	1.42015765
23	MAP3K4	1.27316172
24	MAPK13	1.19401529
25	GRK1	1.18559417
26	TAF1	1.15568243
27	DYRK2	1.10413634
28	CSNK1G3	1.09082218
29	MATK	1.07976399
30	PLK3	1.07630389
31	WNK3	1.05412828
32	SCYL2	1.04085183
33	ADRBK2	1.02629214
34	OXSR1	0.99136627
35	TSSK6	0.95471509
36	MAP2K2	0.92895945
37	MAP3K12	0.90853317
38	CSNK1G2	0.89679074
39	PINK1	0.89311353
40	CSNK1G1	0.89035544
41	IKBKB	0.87340444
42	CSNK1A1L	0.83869583
43	MST4	0.83683588
44	PASK	0.81148891
45	PLK4	0.80439574
46	BRSK2	0.79027533
47	BMPR2	0.78312914
48	AURKA	0.77462181
49	NTRK1	0.69108253
50	MKNK1	0.68940442
51	PIK3CA	0.65593901
52	FRK	0.64255539
53	TEC	0.63938144
54	PRKCQ	0.63348652
55	PLK1	0.62872104
56	BMPR1B	0.62000135
57	IKBKE	0.61123924
58	NEK1	0.58345318
59	ERBB3	0.56621658
60	PBK	0.54723393
61	DYRK1A	0.54425934
62	SYK	0.53520490
63	MYLK	0.53329132
64	ITK	0.53024645
65	PLK2	0.52759485
66	LCK	0.52123816
67	MAP3K14	0.51942260
68	MINK1	0.51229992
69	DAPK3	0.50556407
70	CDK19	0.50078104
71	WEE1	0.50028231
72	CDK14	0.48781218
73	INSRR	0.48583642
74	AURKB	0.47680587
75	EIF2AK2	0.45795124
76	MKNK2	0.45359999
77	CAMK2B	0.45299066
78	RPS6KA4	0.43486607
79	PRKCG	0.42276045
80	MAP4K1	0.40379910
81	RPS6KA5	0.38645701
82	PRKACA	0.38620951
83	CSNK2A1	0.36813578
84	CDK18	0.36504366
85	UHMK1	0.34180098
86	CDK15	0.33219149
87	CAMK2A	0.31911280
88	CDK11A	0.31745909
89	GRK7	0.30195475
90	ATR	0.28719032
91	OBSCN	0.27827009
92	PAK1	0.27637397
93	CSNK2A2	0.26047767
94	LYN	0.24846145
95	CHUK	0.24300737
96	FYN	0.24105798
97	MARK1	0.23989822
98	TAOK2	0.22146348
99	INSR	0.21552553
100	TIE1	0.21152434

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.70843045
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.47499408
3	Parkinsons disease_Homo sapiens_hsa05012	4.28048422
4	Primary immunodeficiency_Homo sapiens_hsa05340	4.06986196
5	Protein export_Homo sapiens_hsa03060	3.24045941
6	Huntingtons disease_Homo sapiens_hsa05016	2.82619794
7	RNA polymerase_Homo sapiens_hsa03020	2.71432622
8	Alzheimers disease_Homo sapiens_hsa05010	2.68707203
9	Ribosome_Homo sapiens_hsa03010	2.35201959
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.28066806
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12601743
12	Fatty acid elongation_Homo sapiens_hsa00062	1.96907152
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.83454617
14	Nicotine addiction_Homo sapiens_hsa05033	1.56078628
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55885132
16	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.55317029
17	Spliceosome_Homo sapiens_hsa03040	1.53837422
18	Sulfur metabolism_Homo sapiens_hsa00920	1.44837723
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.36991798
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.36429362
21	Homologous recombination_Homo sapiens_hsa03440	1.35663232
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.31335392
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.30204816
24	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.27667123
25	DNA replication_Homo sapiens_hsa03030	1.26841851
26	Mismatch repair_Homo sapiens_hsa03430	1.25072491
27	Basal transcription factors_Homo sapiens_hsa03022	1.24313678
28	Butanoate metabolism_Homo sapiens_hsa00650	1.23229760
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21971494
30	Phototransduction_Homo sapiens_hsa04744	1.17892154
31	RNA degradation_Homo sapiens_hsa03018	1.16511068
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06721936
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.01243197
34	Purine metabolism_Homo sapiens_hsa00230	0.99731078
35	Peroxisome_Homo sapiens_hsa04146	0.97297439
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97243362
37	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93449689
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93342758
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.88308085
40	Shigellosis_Homo sapiens_hsa05131	0.87515690
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87309550
42	Propanoate metabolism_Homo sapiens_hsa00640	0.86338099
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85083955
44	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.82573382
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.82294844
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.79219149
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78314283
48	RNA transport_Homo sapiens_hsa03013	0.77884939
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.76108395
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.70511766
51	Metabolic pathways_Homo sapiens_hsa01100	0.70361365
52	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.69859127
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67149460
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65833016
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63795754
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63550026
57	Allograft rejection_Homo sapiens_hsa05330	0.59721702
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.59536228
59	Base excision repair_Homo sapiens_hsa03410	0.59015372
60	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.58605937
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57928072
62	Regulation of autophagy_Homo sapiens_hsa04140	0.57035023
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56432913
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55864675
65	Salmonella infection_Homo sapiens_hsa05132	0.55492402
66	Alcoholism_Homo sapiens_hsa05034	0.54526347
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.54263453
68	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52507574
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52250394
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51591691
71	One carbon pool by folate_Homo sapiens_hsa00670	0.47015187
72	Pyruvate metabolism_Homo sapiens_hsa00620	0.46882202
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46206735
74	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44538705
75	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44016159
76	Retinol metabolism_Homo sapiens_hsa00830	0.43833213
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43497767
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42684055
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.41879128
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40760707
81	Viral myocarditis_Homo sapiens_hsa05416	0.40264484
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40078775
83	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39865709
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.39510580
85	Oocyte meiosis_Homo sapiens_hsa04114	0.38165380
86	Legionellosis_Homo sapiens_hsa05134	0.37274380
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36713556
88	Carbon metabolism_Homo sapiens_hsa01200	0.35406135
89	GABAergic synapse_Homo sapiens_hsa04727	0.33775348
90	Taste transduction_Homo sapiens_hsa04742	0.33155053
91	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33091633
92	Olfactory transduction_Homo sapiens_hsa04740	0.31864332
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31526132
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31277131
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30280445
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28960191
97	Caffeine metabolism_Homo sapiens_hsa00232	0.28643354
98	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27690817
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.26260655
100	p53 signaling pathway_Homo sapiens_hsa04115	0.25433437

DNAJC8P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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