DNAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)6.27802465
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.90097401
3substrate-independent telencephalic tangential migration (GO:0021826)4.90097401
4microtubule severing (GO:0051013)4.61333580
5pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.59858252
6regulation of cilium movement (GO:0003352)4.46683546
7left/right axis specification (GO:0070986)4.33812329
8piRNA metabolic process (GO:0034587)4.12323190
9gonadal mesoderm development (GO:0007506)4.12246795
10pyrimidine nucleotide catabolic process (GO:0006244)3.99578804
11chaperone-mediated protein transport (GO:0072321)3.97043642
12microtubule bundle formation (GO:0001578)3.88371087
13nonmotile primary cilium assembly (GO:0035058)3.85001588
14cilium assembly (GO:0042384)3.79837123
15cilium organization (GO:0044782)3.77269582
16male meiosis (GO:0007140)3.54884764
17response to pheromone (GO:0019236)3.49408134
18motile cilium assembly (GO:0044458)3.48078681
19protein polyglutamylation (GO:0018095)3.47661514
20regulation of female gonad development (GO:2000194)3.46721589
21synaptonemal complex organization (GO:0070193)3.46477948
22pyrimidine nucleobase catabolic process (GO:0006208)3.43760275
23axonemal dynein complex assembly (GO:0070286)3.43663219
24synaptonemal complex assembly (GO:0007130)3.32544813
25fusion of sperm to egg plasma membrane (GO:0007342)3.28107046
26cilium or flagellum-dependent cell motility (GO:0001539)3.26662054
27base-excision repair, AP site formation (GO:0006285)3.20580255
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13260953
29pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12551329
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11058465
31regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.10746349
32regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.10334104
33regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.10334104
34positive regulation of mitochondrial fission (GO:0090141)3.10023082
35regulation of meiosis (GO:0040020)3.08633361
36establishment of mitochondrion localization (GO:0051654)3.07765784
37protein deneddylation (GO:0000338)3.05760499
38primary alcohol catabolic process (GO:0034310)3.04661792
39epithelial cilium movement (GO:0003351)3.03145866
40binding of sperm to zona pellucida (GO:0007339)3.01791978
41cilium movement (GO:0003341)3.01743575
42microtubule-based movement (GO:0007018)2.97350519
43synaptic vesicle docking involved in exocytosis (GO:0016081)2.96313399
44DNA deamination (GO:0045006)2.95102244
45cilium morphogenesis (GO:0060271)2.93140532
46nucleoside diphosphate phosphorylation (GO:0006165)2.88602506
47synaptic vesicle maturation (GO:0016188)2.87439659
48protein retention in ER lumen (GO:0006621)2.86532218
49sperm-egg recognition (GO:0035036)2.85096485
50axonal fasciculation (GO:0007413)2.83419420
51positive regulation of synapse maturation (GO:0090129)2.83404563
52neuronal ion channel clustering (GO:0045161)2.82500089
53histone H2A acetylation (GO:0043968)2.81085931
54plasma membrane fusion (GO:0045026)2.81081197
55sperm motility (GO:0030317)2.79077378
56acrosome reaction (GO:0007340)2.77866144
57cellular component assembly involved in morphogenesis (GO:0010927)2.77615056
58short-term memory (GO:0007614)2.75912020
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.75869906
60viral protein processing (GO:0019082)2.75738984
61viral transcription (GO:0019083)2.74666424
62spermatid development (GO:0007286)2.74581965
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73690621
64meiotic cell cycle (GO:0051321)2.73312444
65regulation of synapse structural plasticity (GO:0051823)2.72269506
66layer formation in cerebral cortex (GO:0021819)2.71754030
67synaptic vesicle exocytosis (GO:0016079)2.70747616
68amyloid precursor protein catabolic process (GO:0042987)2.67758777
69regulation of autophagic vacuole assembly (GO:2000785)2.67247699
70regulation of microtubule-based movement (GO:0060632)2.66086363
71phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.64026432
72protein insertion into membrane (GO:0051205)2.61066989
73nucleobase catabolic process (GO:0046113)2.60416377
74intraciliary transport (GO:0042073)2.59526021
75deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.56687609
76establishment of planar polarity (GO:0001736)2.56263694
77establishment of tissue polarity (GO:0007164)2.56263694
78GTP biosynthetic process (GO:0006183)2.56178172
79regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55940179
80regulation of inclusion body assembly (GO:0090083)2.54713124
81neuron fate determination (GO:0048664)2.54198718
82response to misfolded protein (GO:0051788)2.54187938
83translational termination (GO:0006415)2.51764884
84positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.51442072
85cell-cell junction maintenance (GO:0045217)2.51001065
86cell projection assembly (GO:0030031)2.50918994
87regulation of chromatin binding (GO:0035561)2.50427424
88regulation of early endosome to late endosome transport (GO:2000641)2.50074808
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49976633
90mitochondrion transport along microtubule (GO:0047497)2.49976633
91exploration behavior (GO:0035640)2.49485586
92snRNA transcription (GO:0009301)2.49061182
93protein localization to synapse (GO:0035418)2.48639732
94regulation of meiotic cell cycle (GO:0051445)2.45816901
95regulation of cilium assembly (GO:1902017)2.45349463
96neuron recognition (GO:0008038)2.45259884
97protein complex localization (GO:0031503)2.43498488
98ethanol metabolic process (GO:0006067)2.43363164
99multicellular organism reproduction (GO:0032504)2.43345197
100vocalization behavior (GO:0071625)2.43023738
101ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.41733542
102behavioral defense response (GO:0002209)2.40501101
103behavioral fear response (GO:0001662)2.40501101
104postsynaptic membrane organization (GO:0001941)2.40282629
105sequestering of actin monomers (GO:0042989)2.40011759
106spinal cord association neuron differentiation (GO:0021527)2.39231078
107calcium ion-dependent exocytosis (GO:0017156)2.37965006
108regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37713587
109negative regulation of response to food (GO:0032096)2.37430015
110negative regulation of appetite (GO:0032099)2.37430015
111negative regulation of meiosis (GO:0045835)2.36564622
112seminiferous tubule development (GO:0072520)2.36321864
113microtubule-based transport (GO:0010970)2.36252160
114establishment or maintenance of monopolar cell polarity (GO:0061339)2.36180003
115establishment of monopolar cell polarity (GO:0061162)2.36180003
116behavioral response to nicotine (GO:0035095)2.34708294
117regulation of microtubule depolymerization (GO:0031114)2.34682493
118negative regulation of meiotic cell cycle (GO:0051447)2.34512469
119CDP-diacylglycerol metabolic process (GO:0046341)2.34506165
120glutamate secretion (GO:0014047)2.34489395
121mitotic metaphase plate congression (GO:0007080)2.33972518
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.33818382
123sialylation (GO:0097503)2.33387184
124smoothened signaling pathway (GO:0007224)2.33314939
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.33022698
126negative regulation of microtubule polymerization (GO:0031115)2.32747703
127regulation of synaptic vesicle exocytosis (GO:2000300)2.32610451
128regulation of synaptic vesicle transport (GO:1902803)2.32532377
129polyamine biosynthetic process (GO:0006596)2.32434504
130protein localization to cilium (GO:0061512)2.32173773
131DNA methylation involved in gamete generation (GO:0043046)2.32119206
132mitochondrion degradation (GO:0000422)2.31965265
133viral life cycle (GO:0019058)2.31961371
134cell-cell recognition (GO:0009988)2.31350280
135regulation of vacuole organization (GO:0044088)2.31164126
136segment specification (GO:0007379)2.31082729
137virion assembly (GO:0019068)2.29409746
138lung epithelium development (GO:0060428)2.29259677
139adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.28302198
140ventricular system development (GO:0021591)2.28108810
141pattern specification involved in kidney development (GO:0061004)2.27942939
142negative regulation of organelle assembly (GO:1902116)2.27740292
143cytoskeleton-dependent intracellular transport (GO:0030705)2.26942106
144negative regulation of DNA-templated transcription, elongation (GO:0032785)2.26541988
145positive regulation of megakaryocyte differentiation (GO:0045654)2.25665536
146negative regulation of inclusion body assembly (GO:0090084)2.25162802
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.24744006
148meiotic nuclear division (GO:0007126)2.24128904
149sensory perception of smell (GO:0007608)2.23602456
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.22593286
151spermatogenesis (GO:0007283)2.22145041
152male gamete generation (GO:0048232)2.21654127
153positive regulation of membrane potential (GO:0045838)2.19993314
154locomotory exploration behavior (GO:0035641)2.19445004
155gamete generation (GO:0007276)2.19315566
156fear response (GO:0042596)2.18601785
157deoxyribose phosphate biosynthetic process (GO:0046385)2.18428056
1582-deoxyribonucleotide biosynthetic process (GO:0009265)2.18428056
159regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.17421231
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17359973
161regulation of histone H3-K27 methylation (GO:0061085)2.16221634
162regulation of glutamate receptor signaling pathway (GO:1900449)2.15681235
163cell migration in hindbrain (GO:0021535)2.15504457
164axoneme assembly (GO:0035082)2.14431374
165deoxyribonucleotide catabolic process (GO:0009264)2.14401208
166regulation of synapse maturation (GO:0090128)2.13513639
167cullin deneddylation (GO:0010388)2.13251106
168anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.12398094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.09012894
2EZH2_22144423_ChIP-Seq_EOC_Human3.97334231
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52910362
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52059455
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40745007
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40433242
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26715205
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.24717918
9* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04610139
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.01888693
11* LXR_22292898_ChIP-Seq_THP-1_Human1.96540614
12MYC_18555785_ChIP-Seq_MESCs_Mouse1.95925988
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93893780
14ETS1_20019798_ChIP-Seq_JURKAT_Human1.93738877
15SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.89762506
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88093583
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.84766826
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84765820
19GABP_17652178_ChIP-ChIP_JURKAT_Human1.81353119
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80010308
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.76845533
22SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.75147295
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.70335770
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.66439781
25REST_21632747_ChIP-Seq_MESCs_Mouse1.65844503
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63979563
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63419572
28CTCF_18555785_ChIP-Seq_MESCs_Mouse1.63011160
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.62765640
30GABP_19822575_ChIP-Seq_HepG2_Human1.62152507
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61041320
32XRN2_22483619_ChIP-Seq_HELA_Human1.59290634
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59114263
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.58807413
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54200721
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53828211
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.52498563
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49253896
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49199710
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.48536008
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47562650
42DROSHA_22980978_ChIP-Seq_HELA_Human1.44537302
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.44299408
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44058252
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43630537
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.42950346
47SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42723435
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.42250555
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38354262
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38282154
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37965056
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37519642
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36408985
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36159138
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35340559
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34460117
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32423531
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32423531
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31324943
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30076410
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29826230
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29678005
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28963797
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.28262847
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27766260
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27390481
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26764159
68EST1_17652178_ChIP-ChIP_JURKAT_Human1.25966323
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.25755774
70KDM2B_26808549_Chip-Seq_K562_Human1.24782358
71E2F1_20622854_ChIP-Seq_HELA_Human1.23603875
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23109493
73BCOR_27268052_Chip-Seq_Bcells_Human1.22365430
74SA1_27219007_Chip-Seq_Bcells_Human1.20758195
75SMC4_20622854_ChIP-Seq_HELA_Human1.20076583
76CREB1_26743006_Chip-Seq_LNCaP_Human1.18791716
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18151571
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.16792536
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.16689189
80* TP63_22573176_ChIP-Seq_HFKS_Human1.16211957
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.16042751
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14074098
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14031305
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13685768
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13486120
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13164771
87RACK7_27058665_Chip-Seq_MCF-7_Human1.12900282
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12174885
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11613964
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11267791
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.11151350
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10746023
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10430444
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10417274
95TTF2_22483619_ChIP-Seq_HELA_Human1.10384059
96* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09915067
97CTCF_20526341_ChIP-Seq_ESCs_Human1.09221503
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08922685
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08360538
100TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07887925
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07588942
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07263587
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.06791491
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06339900
105P68_20966046_ChIP-Seq_HELA_Human1.06315532
106DCP1A_22483619_ChIP-Seq_HELA_Human1.05232302
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.05034573
108RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04826436
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.04601260
110MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03943846
111ZNF263_19887448_ChIP-Seq_K562_Human1.03727078
112TP53_22127205_ChIP-Seq_IMR90_Human1.03527248
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03289566
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02455358
115RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02215828
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01475413
117KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00854931
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00068496
119RARB_24833708_ChIP-Seq_LIVER_Mouse0.98988806
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98748357
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97550477
122RING1B_27294783_Chip-Seq_ESCs_Mouse0.97040852
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96873231
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96804108
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.95181039
126ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94724671
127SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94403910
128RNF2_27304074_Chip-Seq_ESCs_Mouse0.94296651
129CIITA_25753668_ChIP-Seq_RAJI_Human0.93981453
130BCL6_27268052_Chip-Seq_Bcells_Human0.93684708
131MYC_22102868_ChIP-Seq_BL_Human0.92250571
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92132431
133TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91565184
134CTCF_21964334_Chip-Seq_Bcells_Human0.91270538
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89805566
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.89631498
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88236261
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87904463
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87611639
140ERA_21632823_ChIP-Seq_H3396_Human0.87444305
141CTCF_27219007_Chip-Seq_Bcells_Human0.87031567
142NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86633963
143RNF2_27304074_Chip-Seq_NSC_Mouse0.86395632
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86211604
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.86188375
146VDR_23849224_ChIP-Seq_CD4+_Human0.85809708
147PHF8_20622854_ChIP-Seq_HELA_Human0.85031047
148GATA3_21867929_ChIP-Seq_CD8_Mouse0.84969846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.16509169
2MP0004859_abnormal_synaptic_plasticity3.71604748
3MP0004133_heterotaxia2.89365460
4MP0005410_abnormal_fertilization2.86924846
5MP0003646_muscle_fatigue2.60563088
6MP0001529_abnormal_vocalization2.47966922
7MP0001984_abnormal_olfaction2.47406859
8MP0009379_abnormal_foot_pigmentation2.44827700
9MP0006292_abnormal_olfactory_placode2.42529186
10MP0005394_taste/olfaction_phenotype2.34212199
11MP0005499_abnormal_olfactory_system2.34212199
12MP0010030_abnormal_orbit_morphology2.29753394
13MP0008877_abnormal_DNA_methylation2.25711534
14MP0003635_abnormal_synaptic_transmissio2.17017150
15MP0005646_abnormal_pituitary_gland2.12976436
16MP0008789_abnormal_olfactory_epithelium2.04914701
17MP0001929_abnormal_gametogenesis1.97784790
18MP0009780_abnormal_chondrocyte_physiolo1.94719073
19MP0004270_analgesia1.91726479
20MP0003880_abnormal_central_pattern1.89500045
21MP0003123_paternal_imprinting1.86860258
22MP0003878_abnormal_ear_physiology1.85303045
23MP0005377_hearing/vestibular/ear_phenot1.85303045
24MP0002063_abnormal_learning/memory/cond1.83220343
25MP0003698_abnormal_male_reproductive1.82225074
26MP0002132_abnormal_respiratory_system1.75512448
27MP0002102_abnormal_ear_morphology1.72606120
28MP0002234_abnormal_pharynx_morphology1.68752389
29MP0003693_abnormal_embryo_hatching1.68589623
30MP0005423_abnormal_somatic_nervous1.64815917
31MP0002210_abnormal_sex_determination1.64787449
32MP0002638_abnormal_pupillary_reflex1.56484763
33MP0008875_abnormal_xenobiotic_pharmacok1.53760398
34MP0002572_abnormal_emotion/affect_behav1.52277583
35MP0000678_abnormal_parathyroid_gland1.50156159
36MP0002734_abnormal_mechanical_nocicepti1.47477916
37MP0009745_abnormal_behavioral_response1.46969921
38MP0001905_abnormal_dopamine_level1.41785491
39MP0000751_myopathy1.40881873
40MP0003718_maternal_effect1.38836072
41MP0010094_abnormal_chromosome_stability1.38133627
42MP0003136_yellow_coat_color1.37106027
43MP0000026_abnormal_inner_ear1.36712336
44MP0004957_abnormal_blastocyst_morpholog1.36266624
45MP0001986_abnormal_taste_sensitivity1.35900559
46MP0005083_abnormal_biliary_tract1.35718327
47MP0002161_abnormal_fertility/fecundity1.35231370
48MP0000653_abnormal_sex_gland1.34547142
49MP0005551_abnormal_eye_electrophysiolog1.33784727
50MP0003111_abnormal_nucleus_morphology1.29470444
51MP0003879_abnormal_hair_cell1.29147610
52MP0002735_abnormal_chemical_nociception1.29118033
53MP0002184_abnormal_innervation1.28534840
54MP0001145_abnormal_male_reproductive1.23790918
55MP0004858_abnormal_nervous_system1.23554942
56MP0002064_seizures1.23526649
57MP0006072_abnormal_retinal_apoptosis1.22392037
58MP0002909_abnormal_adrenal_gland1.21555922
59MP0002736_abnormal_nociception_after1.20684557
60MP0002272_abnormal_nervous_system1.19415736
61MP0003077_abnormal_cell_cycle1.17379137
62MP0002160_abnormal_reproductive_system1.17169290
63MP0000955_abnormal_spinal_cord1.15928017
64MP0004215_abnormal_myocardial_fiber1.15036394
65MP0002233_abnormal_nose_morphology1.13381226
66MP0002882_abnormal_neuron_morphology1.13368874
67MP0001440_abnormal_grooming_behavior1.12674571
68MP0004811_abnormal_neuron_physiology1.12476373
69MP0001485_abnormal_pinna_reflex1.09941120
70MP0002127_abnormal_cardiovascular_syste1.09789104
71MP0001968_abnormal_touch/_nociception1.09631773
72MP0000631_abnormal_neuroendocrine_gland1.06595536
73MP0003938_abnormal_ear_development1.06118496
74MP0002752_abnormal_somatic_nervous1.05642055
75MP0002277_abnormal_respiratory_mucosa1.05406428
76MP0000049_abnormal_middle_ear1.05119898
77MP0001293_anophthalmia1.04828201
78MP0002837_dystrophic_cardiac_calcinosis1.04536881
79MP0002249_abnormal_larynx_morphology1.04185362
80MP0003329_amyloid_beta_deposits1.03813181
81MP0005451_abnormal_body_composition1.03380299
82MP0005248_abnormal_Harderian_gland1.03300151
83MP0001486_abnormal_startle_reflex1.01836993
84MP0000681_abnormal_thyroid_gland1.01307764
85MP0010386_abnormal_urinary_bladder1.00937444
86MP0002557_abnormal_social/conspecific_i1.00856187
87MP0008007_abnormal_cellular_replicative1.00601788
88MP0003861_abnormal_nervous_system1.00238189
89MP0000778_abnormal_nervous_system1.00154277
90MP0003122_maternal_imprinting0.99712274
91MP0009046_muscle_twitch0.97723006
92MP0002152_abnormal_brain_morphology0.97298414
93MP0001970_abnormal_pain_threshold0.97129435
94MP0008995_early_reproductive_senescence0.96599781
95MP0004885_abnormal_endolymph0.94752131
96MP0003942_abnormal_urinary_system0.94196568
97MP0001502_abnormal_circadian_rhythm0.94021224
98MP0002928_abnormal_bile_duct0.93951595
99MP0004142_abnormal_muscle_tone0.93776534
100MP0001188_hyperpigmentation0.93108191
101MP0004145_abnormal_muscle_electrophysio0.91959654
102MP0005195_abnormal_posterior_eye0.90375685
103MP0001963_abnormal_hearing_physiology0.89592146
104MP0005253_abnormal_eye_physiology0.89179823
105MP0008932_abnormal_embryonic_tissue0.87910206
106MP0005645_abnormal_hypothalamus_physiol0.87564722
107MP0003699_abnormal_female_reproductive0.87517957
108MP0003137_abnormal_impulse_conducting0.86686150
109MP0004085_abnormal_heartbeat0.85991679
110MP0003011_delayed_dark_adaptation0.85229878
111MP0000566_synostosis0.84384974
112MP0008058_abnormal_DNA_repair0.83886634
113MP0002822_catalepsy0.82676784
114MP0002067_abnormal_sensory_capabilities0.81567710
115MP0001119_abnormal_female_reproductive0.80027070
116MP0001730_embryonic_growth_arrest0.79659064
117MP0008569_lethality_at_weaning0.79419835
118MP0003121_genomic_imprinting0.79271040
119MP0003787_abnormal_imprinting0.78396982
120MP0000534_abnormal_ureter_morphology0.77827250
121MP0002229_neurodegeneration0.77458896
122MP0002066_abnormal_motor_capabilities/c0.76901955
123MP0005386_behavior/neurological_phenoty0.76741270
124MP0004924_abnormal_behavior0.76741270
125MP0002085_abnormal_embryonic_tissue0.76584018
126MP0005623_abnormal_meninges_morphology0.76574992
127MP0004019_abnormal_vitamin_homeostasis0.74118336
128MP0002733_abnormal_thermal_nociception0.73559204
129MP0001270_distended_abdomen0.73367064
130MP0006276_abnormal_autonomic_nervous0.73118929
131MP0008961_abnormal_basal_metabolism0.72676881
132MP0003119_abnormal_digestive_system0.71157833
133MP0002116_abnormal_craniofacial_bone0.70524818
134MP0001346_abnormal_lacrimal_gland0.70496853
135MP0001324_abnormal_eye_pigmentation0.69746327
136MP0008260_abnormal_autophagy0.68875062
137MP0008004_abnormal_stomach_pH0.68821058

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.89902528
2Chronic bronchitis (HP:0004469)4.49445371
3Abnormality of the lower motor neuron (HP:0002366)3.92600400
4Abnormal respiratory motile cilium physiology (HP:0012261)3.91265047
5Myokymia (HP:0002411)3.74014992
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.59024857
7Absent/shortened dynein arms (HP:0200106)3.59024857
8Abnormality of the nasal mucosa (HP:0000433)3.57387058
9Rhinitis (HP:0012384)3.56486071
10Male infertility (HP:0003251)3.54902139
11Atelectasis (HP:0100750)3.25311085
12Gait imbalance (HP:0002141)3.05460287
13Medial flaring of the eyebrow (HP:0010747)3.05050155
14Spinal muscular atrophy (HP:0007269)3.04626328
15Congenital primary aphakia (HP:0007707)2.95740353
16Infertility (HP:0000789)2.95692602
17Molar tooth sign on MRI (HP:0002419)2.85296750
18Abnormality of midbrain morphology (HP:0002418)2.85296750
19Congenital stationary night blindness (HP:0007642)2.82647227
20Hand muscle atrophy (HP:0009130)2.79466602
21Abnormal respiratory epithelium morphology (HP:0012253)2.77645793
22Abnormal respiratory motile cilium morphology (HP:0005938)2.77645793
23Nephrogenic diabetes insipidus (HP:0009806)2.75076104
24Focal motor seizures (HP:0011153)2.70536127
25Unsteady gait (HP:0002317)2.70235764
26Anencephaly (HP:0002323)2.67668054
27Pancreatic fibrosis (HP:0100732)2.66423503
28Nephronophthisis (HP:0000090)2.59158225
29Polyphagia (HP:0002591)2.58949695
30Sclerocornea (HP:0000647)2.58548374
31Abnormal ciliary motility (HP:0012262)2.55791359
32Delusions (HP:0000746)2.54580419
33True hermaphroditism (HP:0010459)2.52211287
34Chronic sinusitis (HP:0011109)2.42186967
35Recurrent sinusitis (HP:0011108)2.38223969
36Recurrent otitis media (HP:0000403)2.36573240
37Epileptic encephalopathy (HP:0200134)2.30610037
38Abnormality of macular pigmentation (HP:0008002)2.30432363
39Male pseudohermaphroditism (HP:0000037)2.28184763
40Pancreatic cysts (HP:0001737)2.25356342
41Tubulointerstitial nephritis (HP:0001970)2.18327814
42Poor coordination (HP:0002370)2.18156014
43Cerebral hypomyelination (HP:0006808)2.16524730
44Abnormality of the anterior horn cell (HP:0006802)2.13756898
45Degeneration of anterior horn cells (HP:0002398)2.13756898
46Abnormal rod and cone electroretinograms (HP:0008323)2.13624947
47Hyperthyroidism (HP:0000836)2.13484037
48Broad foot (HP:0001769)2.11471295
49Vaginal atresia (HP:0000148)2.08969150
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08949252
51Retinal dysplasia (HP:0007973)2.08936159
52Genital tract atresia (HP:0001827)2.07051738
53Bony spicule pigmentary retinopathy (HP:0007737)2.06210708
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05129254
55Congenital hepatic fibrosis (HP:0002612)2.05027487
56Difficulty climbing stairs (HP:0003551)2.03627056
57Fibular aplasia (HP:0002990)2.02237406
58Distal upper limb amyotrophy (HP:0007149)2.01703770
59Upper limb amyotrophy (HP:0009129)2.01703770
60Occipital encephalocele (HP:0002085)2.00560138
61Renal dysplasia (HP:0000110)2.00378576
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.98815016
63Visual hallucinations (HP:0002367)1.96493835
64Abnormality of cells of the erythroid lineage (HP:0012130)1.96293024
65Atonic seizures (HP:0010819)1.96223698
66Amblyopia (HP:0000646)1.96021326
67Fetal akinesia sequence (HP:0001989)1.95557704
68Ventricular fibrillation (HP:0001663)1.95063915
69Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92808821
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92808821
71Type II lissencephaly (HP:0007260)1.92336128
72Postaxial hand polydactyly (HP:0001162)1.91868599
73Deep palmar crease (HP:0006191)1.91032972
74Hypoplasia of the brainstem (HP:0002365)1.90314063
75Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90314063
76Annular pancreas (HP:0001734)1.86658954
77Abnormal number of erythroid precursors (HP:0012131)1.86151851
78Lissencephaly (HP:0001339)1.84053845
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83895954
80EMG: neuropathic changes (HP:0003445)1.83487315
81Congenital malformation of the right heart (HP:0011723)1.83321610
82Double outlet right ventricle (HP:0001719)1.83321610
83Cystic liver disease (HP:0006706)1.83254113
84Anosmia (HP:0000458)1.82493999
85Bronchiectasis (HP:0002110)1.82282529
86Premature ovarian failure (HP:0008209)1.79032657
87Shawl scrotum (HP:0000049)1.78269804
88Abnormal gallbladder physiology (HP:0012438)1.77731790
89Cholecystitis (HP:0001082)1.77731790
90Aplastic anemia (HP:0001915)1.77579194
91Short femoral neck (HP:0100864)1.76328224
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73217865
93Focal dystonia (HP:0004373)1.72540332
94Ankle clonus (HP:0011448)1.72239135
95Abnormal eating behavior (HP:0100738)1.72042290
96Chronic hepatic failure (HP:0100626)1.71739427
97Bifid tongue (HP:0010297)1.71090473
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.70816653
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70767284
100Focal seizures (HP:0007359)1.70555594
101Secondary amenorrhea (HP:0000869)1.70180666
102Abnormal mitochondria in muscle tissue (HP:0008316)1.69832245
103Abnormality of dentin (HP:0010299)1.69451542
104Torticollis (HP:0000473)1.69081305
105Abnormality of the aortic arch (HP:0012303)1.68886435
106Facial cleft (HP:0002006)1.68413317
107Left ventricular hypertrophy (HP:0001712)1.68290666
108Aplasia/Hypoplasia of the lens (HP:0008063)1.67396524
109Slender long bone (HP:0003100)1.67379862
110Type 2 muscle fiber atrophy (HP:0003554)1.66336781
111Craniofacial dystonia (HP:0012179)1.66224244
112Patellar aplasia (HP:0006443)1.66188804
113Bronchitis (HP:0012387)1.65642360
114Abnormality of the heme biosynthetic pathway (HP:0010472)1.65102698
115Pendular nystagmus (HP:0012043)1.65011325
116Nasal polyposis (HP:0100582)1.64909011
117Preaxial hand polydactyly (HP:0001177)1.64822585
118Adrenal hypoplasia (HP:0000835)1.64811716
119Hyperactive renin-angiotensin system (HP:0000841)1.64084269
120Central scotoma (HP:0000603)1.63873811
121Microretrognathia (HP:0000308)1.63087194
122Postaxial foot polydactyly (HP:0001830)1.62363096
123Split foot (HP:0001839)1.60540135
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.60257571
125Broad distal phalanx of finger (HP:0009836)1.58989161
126Muscle fiber atrophy (HP:0100295)1.58927703
127Abnormality of the renal medulla (HP:0100957)1.58432781
128Down-sloping shoulders (HP:0200021)1.58120922
129Thyroid-stimulating hormone excess (HP:0002925)1.56960149
130Large eyes (HP:0001090)1.56512331
131Anomalous pulmonary venous return (HP:0010772)1.56189546
132Asplenia (HP:0001746)1.56129261
133Supranuclear gaze palsy (HP:0000605)1.55998808
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.54825838
135Acute necrotizing encephalopathy (HP:0006965)1.54220234
136Oculomotor apraxia (HP:0000657)1.54030982
137Specific learning disability (HP:0001328)1.53841046
138Retinitis pigmentosa (HP:0000510)1.53370207
139Optic nerve coloboma (HP:0000588)1.51310295
140Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.50107494
141Truncus arteriosus (HP:0001660)1.50029940
142Decreased testicular size (HP:0008734)1.49438645
143Supernumerary spleens (HP:0009799)1.49199525
144Depressed nasal ridge (HP:0000457)1.47130489
145Abnormal hemoglobin (HP:0011902)1.45804428
146Nephropathy (HP:0000112)1.42027577
147Short nail (HP:0001799)1.41813780
148Renal salt wasting (HP:0000127)1.41812115
149Agitation (HP:0000713)1.41733064
150Maternal diabetes (HP:0009800)1.41186608
151Abnormality of the motor neurons (HP:0002450)1.40047230
152Abnormal neuron morphology (HP:0012757)1.40047230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.87265277
2MOS3.32788405
3MAP3K93.16874717
4KSR23.11432372
5ARAF2.94516654
6EPHA42.77792255
7CCNB12.61630477
8EPHA22.52105663
9CASK2.51566731
10LATS22.44775195
11KSR12.18068868
12BCKDK2.04006788
13TAOK12.00376924
14BMPR21.97699681
15BRAF1.97028855
16CDK191.95717114
17PIM21.93983547
18BCR1.88468963
19NEK21.87104430
20MAPKAPK31.83691821
21EPHB21.81438841
22NTRK31.80420618
23EEF2K1.77701593
24PAK61.72065243
25DYRK21.71485356
26MAP3K131.68619185
27PDK31.66438917
28PDK41.66438917
29LIMK11.64911769
30BUB11.61725906
31RAF11.56171535
32MUSK1.55570395
33MAP3K121.53649261
34ICK1.49907070
35DAPK11.47510091
36MAPK131.41199276
37MAP3K61.37025883
38STK381.35831475
39CSNK1G31.35321060
40TESK11.34139403
41LRRK21.32418671
42EIF2AK11.24194990
43MAP3K41.23698036
44SIK21.23614825
45DYRK31.22463781
46NTRK21.22343776
47VRK11.20967744
48STK38L1.19897467
49CDC71.18246302
50CDK81.16627568
51MARK11.15549425
52MINK11.15333484
53CSNK1G21.12189631
54SIK31.12002107
55NEK11.10094410
56VRK21.09735188
57TYRO31.08996995
58TESK21.04718645
59MAPK151.04175715
60EPHB11.01524054
61NME11.00227484
62CSNK1A1L0.99986537
63PTK2B0.99022699
64ACVR1B0.98763217
65LMTK20.98011316
66RPS6KA20.94056043
67TTK0.93116511
68EPHA30.92045556
69TRIM280.90673580
70TRIB30.89858429
71PLK40.86751363
72CDK180.83861363
73DYRK1B0.81332160
74SMG10.80755233
75PLK10.80628220
76CDK150.80560037
77CSNK1G10.80076287
78MAP4K20.78718717
79CDK11A0.78187307
80WEE10.77814655
81PINK10.77378907
82CAMK2G0.75778776
83BRSK10.74714146
84DAPK20.73000286
85AURKA0.72070002
86CAMKK10.70938263
87PAK40.70445119
88MST40.69914922
89CDK140.68349639
90WNK30.68203252
91MAP2K70.67307537
92STK160.65134039
93TAOK20.64759666
94TNIK0.64634136
95STK110.60724676
96MAP3K110.60395395
97GRK50.59313414
98TAOK30.59286514
99ILK0.58850934
100DAPK30.58626121
101PRKD20.57590690
102PHKG10.56821718
103PHKG20.56821718
104MARK20.55543221
105MAP2K40.54529593
106CDK50.53479429
107CAMK10.53377221
108PAK10.52980060
109RPS6KA40.52951742
110PRKCZ0.51652196
111CAMKK20.50824035
112BMX0.50766075
113SIK10.49714491
114UHMK10.48447220
115PRKCG0.47969030
116RIPK10.47668336
117MAP2K10.47514230
118MAP3K50.46457141
119MAP3K10.44905353
120CHEK20.44463908
121PKN10.43184060
122RPS6KL10.43035307
123RPS6KC10.43035307
124NME20.40891412
125MAP3K100.40719202
126ABL20.40473175
127NTRK10.39811686
128PRKACA0.39734624
129RPS6KB20.39540575
130SGK4940.39140827
131SGK2230.39140827
132MATK0.38997069
133CDK90.38565088
134CAMK40.37840824
135MAP2K60.37556019
136PAK30.36933947
137RPS6KA60.35047145
138PDK20.33613739
139ERBB30.33425864
140PKN20.33157161
141CAMK2A0.32990473
142PRKCI0.32821699
143ADRBK10.31350401
144DYRK1A0.30666427
145PRKCD0.30577543

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.58893103
2Olfactory transduction_Homo sapiens_hsa047402.48972153
3Phototransduction_Homo sapiens_hsa047442.44246901
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25124088
5Phenylalanine metabolism_Homo sapiens_hsa003602.19528551
6Oocyte meiosis_Homo sapiens_hsa041142.17836221
7Sulfur relay system_Homo sapiens_hsa041222.14537517
8Base excision repair_Homo sapiens_hsa034101.97205472
9DNA replication_Homo sapiens_hsa030301.91502091
10Tyrosine metabolism_Homo sapiens_hsa003501.84059617
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81223986
12Amphetamine addiction_Homo sapiens_hsa050311.73315079
13Long-term potentiation_Homo sapiens_hsa047201.68887460
14Nicotine addiction_Homo sapiens_hsa050331.64311833
15RNA polymerase_Homo sapiens_hsa030201.60902732
16Circadian entrainment_Homo sapiens_hsa047131.60808433
17Cell cycle_Homo sapiens_hsa041101.60081280
18Vitamin B6 metabolism_Homo sapiens_hsa007501.59761234
19RNA transport_Homo sapiens_hsa030131.58680640
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55125271
21Basal transcription factors_Homo sapiens_hsa030221.51190581
22Glutathione metabolism_Homo sapiens_hsa004801.45440843
23Ribosome_Homo sapiens_hsa030101.44702818
24Dopaminergic synapse_Homo sapiens_hsa047281.44467270
25RNA degradation_Homo sapiens_hsa030181.40833094
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40160468
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39914975
28beta-Alanine metabolism_Homo sapiens_hsa004101.38420972
29Glutamatergic synapse_Homo sapiens_hsa047241.38303221
30Huntingtons disease_Homo sapiens_hsa050161.38035355
31Spliceosome_Homo sapiens_hsa030401.37586107
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35935144
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35764963
34Steroid biosynthesis_Homo sapiens_hsa001001.35461251
35Circadian rhythm_Homo sapiens_hsa047101.35107699
36Fatty acid elongation_Homo sapiens_hsa000621.34100307
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33565640
38Mismatch repair_Homo sapiens_hsa034301.32807567
39Pyrimidine metabolism_Homo sapiens_hsa002401.32531863
40Nucleotide excision repair_Homo sapiens_hsa034201.29442125
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28827492
42Collecting duct acid secretion_Homo sapiens_hsa049661.28792395
43GnRH signaling pathway_Homo sapiens_hsa049121.27017321
44Cardiac muscle contraction_Homo sapiens_hsa042601.25913505
45Proteasome_Homo sapiens_hsa030501.24747338
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24235087
47mRNA surveillance pathway_Homo sapiens_hsa030151.23020370
48Cholinergic synapse_Homo sapiens_hsa047251.21829888
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21714853
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20753767
51Cocaine addiction_Homo sapiens_hsa050301.19980171
52Peroxisome_Homo sapiens_hsa041461.19926668
53Insulin secretion_Homo sapiens_hsa049111.19136915
54Chemical carcinogenesis_Homo sapiens_hsa052041.18735406
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17936614
56Purine metabolism_Homo sapiens_hsa002301.17167682
57Morphine addiction_Homo sapiens_hsa050321.17137374
58Parkinsons disease_Homo sapiens_hsa050121.15747048
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14814373
60GABAergic synapse_Homo sapiens_hsa047271.12705748
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12508882
62Vibrio cholerae infection_Homo sapiens_hsa051101.09156222
63Oxidative phosphorylation_Homo sapiens_hsa001901.07190523
64Oxytocin signaling pathway_Homo sapiens_hsa049211.06314484
65Histidine metabolism_Homo sapiens_hsa003401.04283759
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04005109
67Taste transduction_Homo sapiens_hsa047421.01665457
68Basal cell carcinoma_Homo sapiens_hsa052171.00930768
69Gap junction_Homo sapiens_hsa045401.00056708
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99968795
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98688296
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96725337
73Homologous recombination_Homo sapiens_hsa034400.95445321
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93974628
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93758352
76VEGF signaling pathway_Homo sapiens_hsa043700.89976980
77Arginine and proline metabolism_Homo sapiens_hsa003300.89892165
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89214182
79Galactose metabolism_Homo sapiens_hsa000520.88774818
80Calcium signaling pathway_Homo sapiens_hsa040200.86740249
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86202423
82Melanogenesis_Homo sapiens_hsa049160.84869973
83Estrogen signaling pathway_Homo sapiens_hsa049150.83430616
84Serotonergic synapse_Homo sapiens_hsa047260.83196922
85N-Glycan biosynthesis_Homo sapiens_hsa005100.82999475
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82808255
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81504367
88Long-term depression_Homo sapiens_hsa047300.81144821
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80474897
90Gastric acid secretion_Homo sapiens_hsa049710.78848569
91Alcoholism_Homo sapiens_hsa050340.77833923
92Colorectal cancer_Homo sapiens_hsa052100.77084473
93Thyroid cancer_Homo sapiens_hsa052160.76459257
94Salivary secretion_Homo sapiens_hsa049700.76419363
95Ovarian steroidogenesis_Homo sapiens_hsa049130.76401885
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76088018
97Alzheimers disease_Homo sapiens_hsa050100.73626000
98Metabolic pathways_Homo sapiens_hsa011000.73212202
99cAMP signaling pathway_Homo sapiens_hsa040240.71041355
100Tight junction_Homo sapiens_hsa045300.70990238
101Pentose phosphate pathway_Homo sapiens_hsa000300.70342816
102Wnt signaling pathway_Homo sapiens_hsa043100.69069726
103Fanconi anemia pathway_Homo sapiens_hsa034600.68812706
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68810228
105Glioma_Homo sapiens_hsa052140.68647890
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68323648
107Glucagon signaling pathway_Homo sapiens_hsa049220.67693219
108Hippo signaling pathway_Homo sapiens_hsa043900.66445047
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65852411
110Protein export_Homo sapiens_hsa030600.65806683
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63746245
112Hedgehog signaling pathway_Homo sapiens_hsa043400.63028179
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62451625
114mTOR signaling pathway_Homo sapiens_hsa041500.62195581
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58374984
116Sphingolipid metabolism_Homo sapiens_hsa006000.58358748
117Axon guidance_Homo sapiens_hsa043600.57776661
118Renin secretion_Homo sapiens_hsa049240.57028620
119Fructose and mannose metabolism_Homo sapiens_hsa000510.56491429
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56112404
121Carbon metabolism_Homo sapiens_hsa012000.54280903
122Notch signaling pathway_Homo sapiens_hsa043300.53389411
123Butanoate metabolism_Homo sapiens_hsa006500.52996999
124Phagosome_Homo sapiens_hsa041450.52816249
125Bladder cancer_Homo sapiens_hsa052190.52135869
126Biosynthesis of amino acids_Homo sapiens_hsa012300.51574427
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50965736
128TGF-beta signaling pathway_Homo sapiens_hsa043500.50747701
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.50358900
130Salmonella infection_Homo sapiens_hsa051320.50177907
131Regulation of autophagy_Homo sapiens_hsa041400.49982537
132Fatty acid metabolism_Homo sapiens_hsa012120.49668000
133Dilated cardiomyopathy_Homo sapiens_hsa054140.48113944
134Endocytosis_Homo sapiens_hsa041440.47906253
135Lysosome_Homo sapiens_hsa041420.47843756
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.47473432
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47304778
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46875748
139Pyruvate metabolism_Homo sapiens_hsa006200.46608408
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.46256561
141Choline metabolism in cancer_Homo sapiens_hsa052310.45708780
142Shigellosis_Homo sapiens_hsa051310.44329810
143MAPK signaling pathway_Homo sapiens_hsa040100.43950372
144Ras signaling pathway_Homo sapiens_hsa040140.43328991
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.42774234
146Sulfur metabolism_Homo sapiens_hsa009200.41856623
147Arachidonic acid metabolism_Homo sapiens_hsa005900.39857322
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.39527977
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.39130105
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.38951658
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38118760
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38039608
153Folate biosynthesis_Homo sapiens_hsa007900.36641170

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