DNALI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.81257286
2axoneme assembly (GO:0035082)9.67760841
3ventricular system development (GO:0021591)9.60360170
4fusion of sperm to egg plasma membrane (GO:0007342)9.33108545
5acrosome reaction (GO:0007340)8.31867746
6sperm-egg recognition (GO:0035036)8.19328982
7acrosome assembly (GO:0001675)7.96576847
8multicellular organism reproduction (GO:0032504)7.88114288
9cell wall macromolecule catabolic process (GO:0016998)7.85877311
10cell wall macromolecule metabolic process (GO:0044036)7.85877311
11spermatid development (GO:0007286)7.63031897
12binding of sperm to zona pellucida (GO:0007339)7.54439225
13regulation of cilium movement (GO:0003352)7.47192832
14cell-cell recognition (GO:0009988)7.28921150
15nucleoside diphosphate phosphorylation (GO:0006165)7.15891104
16GTP biosynthetic process (GO:0006183)7.14094949
17plasma membrane fusion (GO:0045026)7.13835877
18left/right axis specification (GO:0070986)7.01473282
19reproduction (GO:0000003)6.50164953
20piRNA metabolic process (GO:0034587)6.46414713
21negative regulation of inclusion body assembly (GO:0090084)6.39767843
22UTP biosynthetic process (GO:0006228)6.33465303
23intraciliary transport (GO:0042073)5.96716552
24UTP metabolic process (GO:0046051)5.93707420
25male meiosis (GO:0007140)5.93167256
26synaptonemal complex organization (GO:0070193)5.61660863
27cilium organization (GO:0044782)5.60472800
28sperm capacitation (GO:0048240)5.49973550
29* single fertilization (GO:0007338)5.31462050
30cilium assembly (GO:0042384)5.23396156
31spermatogenesis (GO:0007283)5.12777164
32male gamete generation (GO:0048232)5.10464433
33regulation of inclusion body assembly (GO:0090083)5.08045179
34left/right pattern formation (GO:0060972)4.97403035
35male meiosis I (GO:0007141)4.93952914
36cilium morphogenesis (GO:0060271)4.92318007
37synaptonemal complex assembly (GO:0007130)4.81402716
38guanosine-containing compound biosynthetic process (GO:1901070)4.73848787
39* fertilization (GO:0009566)4.72345700
40microtubule-based movement (GO:0007018)4.72109544
41gamete generation (GO:0007276)4.71682628
42CTP biosynthetic process (GO:0006241)4.70903633
43CTP metabolic process (GO:0046036)4.70903633
44cellular component assembly involved in morphogenesis (GO:0010927)4.60706981
45microtubule bundle formation (GO:0001578)4.54895556
46regulation of microtubule-based movement (GO:0060632)4.49370984
47primary alcohol catabolic process (GO:0034310)4.32830811
48pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.27987980
49germ cell development (GO:0007281)4.23926531
50protein localization to cilium (GO:0061512)4.11902585
51pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.11011900
52organic cation transport (GO:0015695)4.08058979
53meiotic cell cycle (GO:0051321)3.99868801
54cellular process involved in reproduction in multicellular organism (GO:0022412)3.99301893
55microtubule severing (GO:0051013)3.98728844
56meiosis I (GO:0007127)3.89187437
57DNA methylation involved in gamete generation (GO:0043046)3.88541324
58nucleotide phosphorylation (GO:0046939)3.83672488
59nonmotile primary cilium assembly (GO:0035058)3.81446783
60calcium ion-dependent exocytosis (GO:0017156)3.75829105
61multicellular organismal reproductive process (GO:0048609)3.71852223
62vitamin transmembrane transport (GO:0035461)3.71371427
63pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.70038194
64microtubule depolymerization (GO:0007019)3.68792468
65cell recognition (GO:0008037)3.67238427
66lung epithelium development (GO:0060428)3.63860111
67lateral sprouting from an epithelium (GO:0060601)3.61304647
68centriole assembly (GO:0098534)3.58114563
69nucleoside diphosphate metabolic process (GO:0009132)3.56753640
70ethanol metabolic process (GO:0006067)3.55939681
71cell projection assembly (GO:0030031)3.53874105
72meiotic nuclear division (GO:0007126)3.42412277
73protein refolding (GO:0042026)3.40198265
74spermatid nucleus differentiation (GO:0007289)3.37253226
75establishment of planar polarity (GO:0001736)3.35967861
76establishment of tissue polarity (GO:0007164)3.35967861
77establishment or maintenance of monopolar cell polarity (GO:0061339)3.33760046
78establishment of monopolar cell polarity (GO:0061162)3.33760046
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.30051874
80chaperone-mediated protein complex assembly (GO:0051131)3.28534722
81lateral ventricle development (GO:0021670)3.26811776
82chromosome organization involved in meiosis (GO:0070192)3.25743349
83one-carbon compound transport (GO:0019755)3.20095126
84protein polyglutamylation (GO:0018095)3.19453027
85establishment of apical/basal cell polarity (GO:0035089)3.19340196
86microtubule polymerization or depolymerization (GO:0031109)3.11392777
87apical protein localization (GO:0045176)3.09402711
88retinal rod cell development (GO:0046548)3.04598532
89seminiferous tubule development (GO:0072520)3.02496499
90negative regulation of T cell differentiation in thymus (GO:0033085)2.98653145
91appendage development (GO:0048736)2.94257559
92limb development (GO:0060173)2.94257559
93positive regulation of smoothened signaling pathway (GO:0045880)2.83634392
94centriole replication (GO:0007099)2.83318956
95pyrimidine nucleobase catabolic process (GO:0006208)2.81479817
96diterpenoid biosynthetic process (GO:0016102)2.81350376
97photoreceptor cell maintenance (GO:0045494)2.79672774
98determination of left/right symmetry (GO:0007368)2.77339788
99glomerular epithelial cell development (GO:0072310)2.75014484
100ethanol oxidation (GO:0006069)2.73080847
101regulation of collateral sprouting (GO:0048670)2.71410877
102multicellular organismal development (GO:0007275)2.71025594
103organelle assembly (GO:0070925)2.70806675
104determination of bilateral symmetry (GO:0009855)2.67728260
105cytoplasmic microtubule organization (GO:0031122)2.64465011
106specification of symmetry (GO:0009799)2.62971427
107microtubule-based process (GO:0007017)2.62538564
108response to xenobiotic stimulus (GO:0009410)2.60936557
109retinoic acid metabolic process (GO:0042573)2.59751596
110regulation of smoothened signaling pathway (GO:0008589)2.59044829
111asymmetric protein localization (GO:0008105)2.57947360
112pyrimidine-containing compound transmembrane transport (GO:0072531)2.57189499
113purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.56256148
114terpenoid biosynthetic process (GO:0016114)2.54523686
115heart looping (GO:0001947)2.52892677
116retinal ganglion cell axon guidance (GO:0031290)2.50798657
117smoothened signaling pathway (GO:0007224)2.48958933
118aldehyde catabolic process (GO:0046185)2.48135257
119purine nucleoside triphosphate biosynthetic process (GO:0009145)2.47706041
120ear development (GO:0043583)2.47479251
121spinal cord motor neuron differentiation (GO:0021522)2.47136669
122pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.46791509
123glycerol ether metabolic process (GO:0006662)2.46009428
124genitalia morphogenesis (GO:0035112)2.42170934
125embryonic heart tube morphogenesis (GO:0003143)2.40415404
126otic vesicle formation (GO:0030916)2.39443658
127negative regulation of organelle assembly (GO:1902116)2.39267898
128brain morphogenesis (GO:0048854)2.38753153
129exogenous drug catabolic process (GO:0042738)2.36786415
130camera-type eye morphogenesis (GO:0048593)2.35794259
131pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.35760711
132cornea development in camera-type eye (GO:0061303)2.35748898
133nucleoside triphosphate biosynthetic process (GO:0009142)2.35113384
134glutathione derivative biosynthetic process (GO:1901687)2.34604461
135glutathione derivative metabolic process (GO:1901685)2.34604461
136chromosome condensation (GO:0030261)2.33491827
137ADP metabolic process (GO:0046031)2.33367571
138regulation of interleukin-5 production (GO:0032674)2.32733642
139limb bud formation (GO:0060174)2.31170481
140auditory behavior (GO:0031223)2.29094772
141neuronal stem cell maintenance (GO:0097150)2.28357064
142negative regulation of B cell mediated immunity (GO:0002713)2.27734030
143negative regulation of immunoglobulin mediated immune response (GO:0002890)2.27734030
144presynaptic membrane assembly (GO:0097105)2.26117219
145positive regulation of gastrulation (GO:2000543)2.25984051
146photoreceptor cell differentiation (GO:0046530)2.25029357
147eye photoreceptor cell differentiation (GO:0001754)2.25029357
148retinal cone cell development (GO:0046549)2.24617165
149nucleobase catabolic process (GO:0046113)2.24229245
150neuron fate determination (GO:0048664)2.20095443
151cell differentiation in spinal cord (GO:0021515)2.17262635
152negative regulation of humoral immune response (GO:0002921)2.16824009
153regulation of microtubule depolymerization (GO:0031114)2.16617905
154calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.15644502
155neurotransmitter catabolic process (GO:0042135)2.15275344
156axonal fasciculation (GO:0007413)2.15253255
157presynaptic membrane organization (GO:0097090)2.15171781
158vocalization behavior (GO:0071625)2.14138587
159cilium or flagellum-dependent cell motility (GO:0001539)16.0006160
160axonemal dynein complex assembly (GO:0070286)15.2892121
161cilium movement (GO:0003341)15.2727722
162epithelial cilium movement (GO:0003351)13.5594185
163motile cilium assembly (GO:0044458)11.5498673
164epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.9149874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.87275684
2EZH2_22144423_ChIP-Seq_EOC_Human3.82905920
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76670404
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.73144202
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.54421733
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45192740
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.43309442
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25281744
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13894352
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07494099
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07293665
12PIAS1_25552417_ChIP-Seq_VCAP_Human2.06737988
13VDR_22108803_ChIP-Seq_LS180_Human2.01697528
14DROSHA_22980978_ChIP-Seq_HELA_Human2.01299328
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92773420
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89991793
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.86156858
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85991918
19ELK4_26923725_Chip-Seq_MESODERM_Mouse1.81135575
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78990380
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69309181
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66627615
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65234457
24TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63305507
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62138361
26TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60285615
27RNF2_27304074_Chip-Seq_NSC_Mouse1.59718257
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.57680861
29FUS_26573619_Chip-Seq_HEK293_Human1.56845487
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55517077
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.54310485
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53314664
33SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.52469254
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52182940
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.48767888
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47607045
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.47448774
38ZNF274_21170338_ChIP-Seq_K562_Hela1.47231049
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47211351
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46447043
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46447043
42TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45602373
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45067966
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44660451
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43534712
46CBP_20019798_ChIP-Seq_JUKART_Human1.43534712
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.43500417
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42760122
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.42445398
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.42324008
51GBX2_23144817_ChIP-Seq_PC3_Human1.42199217
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41928074
53EWS_26573619_Chip-Seq_HEK293_Human1.41601211
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39660497
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39176877
56P300_19829295_ChIP-Seq_ESCs_Human1.38895538
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35745234
58STAT1_17558387_ChIP-Seq_HELA_Human1.34353713
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30745629
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29357838
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28797540
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.27752053
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27669536
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.27593254
65REST_21632747_ChIP-Seq_MESCs_Mouse1.27314601
66BCAT_22108803_ChIP-Seq_LS180_Human1.26714588
67TP53_18474530_ChIP-ChIP_U2OS_Human1.26180376
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25495015
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25242819
70KDM2B_26808549_Chip-Seq_REH_Human1.23913861
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23888924
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.23274103
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.23272251
74ER_23166858_ChIP-Seq_MCF-7_Human1.21871455
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21446324
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20960947
77IGF1R_20145208_ChIP-Seq_DFB_Human1.20509196
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19679878
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.18457466
80GF1_26923725_Chip-Seq_HPCs_Mouse1.16086074
81GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.16058908
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.15541014
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15507752
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15441366
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.15439203
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14578139
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14031047
88TCF4_22108803_ChIP-Seq_LS180_Human1.14021853
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13435693
90RUNX2_22187159_ChIP-Seq_PCA_Human1.13106840
91LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.12703813
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12637504
93SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.12624571
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11364865
95P53_22387025_ChIP-Seq_ESCs_Mouse1.10570061
96TAF15_26573619_Chip-Seq_HEK293_Human1.10501104
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10400371
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10341360
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.10258833
100P53_21459846_ChIP-Seq_SAOS-2_Human1.10242465
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10111294
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10086939
103STAT3_23295773_ChIP-Seq_U87_Human1.09994893
104AHR_22903824_ChIP-Seq_MCF-7_Human1.09406108
105P300_18555785_Chip-Seq_ESCs_Mouse1.09145706
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.08880013
107JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08400542
108AR_25329375_ChIP-Seq_VCAP_Human1.08320393
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07157366
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07044900
111SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06991852
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06779414
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06146320
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.04855138
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04443098
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.04373776
117GATA3_21867929_ChIP-Seq_CD8_Mouse1.04269513
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03933246
119AR_21572438_ChIP-Seq_LNCaP_Human1.03329455
120SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03308652
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02381413
122* TBL1_22424771_ChIP-Seq_293T_Human1.02191477
123* ETV1_20927104_ChIP-Seq_GIST48_Human1.00618275
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00532164
125* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00449184
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00139271
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99750368
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99244994
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99207675
130ZFX_18555785_Chip-Seq_ESCs_Mouse0.98988671
131CMYC_18555785_Chip-Seq_ESCs_Mouse0.98840962
132* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98622513
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.98281548
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.98068993
135EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98024870
136RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98024870
137KLF4_18555785_Chip-Seq_ESCs_Mouse0.97719298
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.97672137
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.97318687
140LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97307855
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.97276068
142PU1_27457419_Chip-Seq_LIVER_Mouse0.96962725
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.96741730
144* PHF8_20622853_ChIP-Seq_HELA_Human0.96611582
145* NFYB_21822215_ChIP-Seq_K562_Human0.96424160
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.95945864
147FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95945864
148SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95720676
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95034485
150TCF4_23295773_ChIP-Seq_U87_Human0.94785368
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94702068
152SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92628211
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.92529816
154FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92088808
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91657861
156NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91392987
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90903035
158REST_18959480_ChIP-ChIP_MESCs_Mouse0.89193467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.06296744
2MP0002653_abnormal_ependyma_morphology4.85147763
3MP0001929_abnormal_gametogenesis4.56486318
4MP0003136_yellow_coat_color4.07683754
5MP0005623_abnormal_meninges_morphology3.75844001
6MP0000566_synostosis3.26643502
7MP0002210_abnormal_sex_determination2.95954504
8MP0008789_abnormal_olfactory_epithelium2.88702074
9MP0008877_abnormal_DNA_methylation2.86706577
10MP0008004_abnormal_stomach_pH2.80033783
11MP0002161_abnormal_fertility/fecundity2.70801453
12MP0005394_taste/olfaction_phenotype2.42295482
13MP0005499_abnormal_olfactory_system2.42295482
14MP0001145_abnormal_male_reproductive2.40962546
15MP0010030_abnormal_orbit_morphology2.28038334
16MP0005670_abnormal_white_adipose2.11454543
17MP0000653_abnormal_sex_gland2.10643599
18MP0002160_abnormal_reproductive_system2.10406307
19MP0002638_abnormal_pupillary_reflex2.03310189
20MP0005410_abnormal_fertilization12.5090029
21MP0001529_abnormal_vocalization1.99331478
22MP0003122_maternal_imprinting1.94660908
23MP0005646_abnormal_pituitary_gland1.89901855
24MP0004133_heterotaxia1.89182711
25MP0003880_abnormal_central_pattern1.88493177
26MP0002282_abnormal_trachea_morphology1.86813955
27MP0009046_muscle_twitch1.84937874
28MP0002822_catalepsy1.84108939
29MP0001984_abnormal_olfaction1.81755352
30MP0004043_abnormal_pH_regulation1.79293463
31MP0002277_abnormal_respiratory_mucosa1.71154328
32MP0005248_abnormal_Harderian_gland1.70921114
33MP0001440_abnormal_grooming_behavior1.63269289
34MP0009379_abnormal_foot_pigmentation1.61992473
35MP0001485_abnormal_pinna_reflex1.60849766
36MP0002928_abnormal_bile_duct1.55878408
37MP0002233_abnormal_nose_morphology1.50864299
38MP0006276_abnormal_autonomic_nervous1.46548866
39MP0003283_abnormal_digestive_organ1.42701846
40MP0005423_abnormal_somatic_nervous1.39529045
41MP0003646_muscle_fatigue1.38594975
42MP0006292_abnormal_olfactory_placode1.29768563
43MP0000955_abnormal_spinal_cord1.29648952
44MP0006072_abnormal_retinal_apoptosis1.28663752
45MP0003938_abnormal_ear_development1.26904694
46MP0003950_abnormal_plasma_membrane1.26783240
47MP0002938_white_spotting1.26593182
48MP0008995_early_reproductive_senescence1.23991802
49MP0001502_abnormal_circadian_rhythm1.20480143
50MP0003890_abnormal_embryonic-extraembry1.19208243
51MP0002736_abnormal_nociception_after1.16569373
52MP0000383_abnormal_hair_follicle1.14652043
53MP0005389_reproductive_system_phenotype1.11000748
54MP0001346_abnormal_lacrimal_gland1.10185319
55MP0001486_abnormal_startle_reflex1.10169920
56MP0001765_abnormal_ion_homeostasis1.10103220
57MP0001299_abnormal_eye_distance/1.07264405
58MP0005388_respiratory_system_phenotype1.06740353
59MP0002133_abnormal_respiratory_system1.06740353
60MP0004885_abnormal_endolymph1.03920920
61MP0004859_abnormal_synaptic_plasticity1.03894763
62MP0001188_hyperpigmentation1.03534514
63MP0003787_abnormal_imprinting1.03422484
64MP0001963_abnormal_hearing_physiology1.00773941
65MP0003119_abnormal_digestive_system0.99743180
66MP0005551_abnormal_eye_electrophysiolog0.98942097
67MP0005647_abnormal_sex_gland0.98611289
68MP0002882_abnormal_neuron_morphology0.96188501
69MP0001958_emphysema0.95974505
70MP0001986_abnormal_taste_sensitivity0.94613825
71MP0001286_abnormal_eye_development0.94429445
72MP0002249_abnormal_larynx_morphology0.93498381
73MP0004233_abnormal_muscle_weight0.89872442
74MP0001968_abnormal_touch/_nociception0.89680140
75MP0003121_genomic_imprinting0.89648741
76MP0001970_abnormal_pain_threshold0.87638583
77MP0002184_abnormal_innervation0.85221509
78MP0003045_fibrosis0.82045092
79MP0003690_abnormal_glial_cell0.81497940
80MP0003755_abnormal_palate_morphology0.79662192
81MP0004142_abnormal_muscle_tone0.78887206
82MP0005187_abnormal_penis_morphology0.78369324
83MP0002697_abnormal_eye_size0.77888397
84MP0010678_abnormal_skin_adnexa0.76465688
85MP0002067_abnormal_sensory_capabilities0.76190757
86MP0002063_abnormal_learning/memory/cond0.74995261
87MP0002234_abnormal_pharynx_morphology0.74720235
88MP0003011_delayed_dark_adaptation0.73922565
89MP0002168_other_aberrant_phenotype0.73296924
90MP0001851_eye_inflammation0.73216717
91MP0005083_abnormal_biliary_tract0.72899193
92MP0003942_abnormal_urinary_system0.71714043
93MP0005084_abnormal_gallbladder_morpholo0.71669587
94MP0000049_abnormal_middle_ear0.71424600
95MP0003115_abnormal_respiratory_system0.71216102
96MP0002557_abnormal_social/conspecific_i0.69884606
97MP0005253_abnormal_eye_physiology0.69401884
98MP0003634_abnormal_glial_cell0.68888297
99MP0002132_abnormal_respiratory_system0.68362923
100MP0004381_abnormal_hair_follicle0.66976959
101MP0008875_abnormal_xenobiotic_pharmacok0.66575459
102MP0005391_vision/eye_phenotype0.65617422
103MP0001177_atelectasis0.64669044
104MP0002152_abnormal_brain_morphology0.64050230
105MP0005636_abnormal_mineral_homeostasis0.63899119
106MP0003937_abnormal_limbs/digits/tail_de0.61455216
107MP0001270_distended_abdomen0.60466551
108MP0003861_abnormal_nervous_system0.60276791
109MP0003279_aneurysm0.59509368
110MP0002572_abnormal_emotion/affect_behav0.59123916
111MP0002734_abnormal_mechanical_nocicepti0.58725602
112MP0009745_abnormal_behavioral_response0.58240588
113MP0000778_abnormal_nervous_system0.57616997
114MP0001501_abnormal_sleep_pattern0.57039502
115MP0000428_abnormal_craniofacial_morphol0.56723787
116MP0003878_abnormal_ear_physiology0.56488691
117MP0005377_hearing/vestibular/ear_phenot0.56488691
118MP0002405_respiratory_system_inflammati0.53872792
119MP0002092_abnormal_eye_morphology0.52102452
120MP0009250_abnormal_appendicular_skeleto0.51485290
121MP0004270_analgesia0.50954582
122MP0004782_abnormal_surfactant_physiolog0.49783568
123MP0004858_abnormal_nervous_system0.48646790
124MP0002295_abnormal_pulmonary_circulatio0.48524597
125MP0009115_abnormal_fat_cell0.47936710
126MP0001293_anophthalmia0.47314440
127MP0004145_abnormal_muscle_electrophysio0.46777567
128MP0005409_darkened_coat_color0.45708852
129MP0002064_seizures0.45469465
130MP0000631_abnormal_neuroendocrine_gland0.45378038
131MP0000432_abnormal_head_morphology0.42575685
132MP0002116_abnormal_craniofacial_bone0.42013322
133MP0002272_abnormal_nervous_system0.41555202
134MP0002909_abnormal_adrenal_gland0.41395078
135MP0000470_abnormal_stomach_morphology0.40948306
136MP0002102_abnormal_ear_morphology0.40947591
137MP0005195_abnormal_posterior_eye0.40790219
138MP0003948_abnormal_gas_homeostasis0.40554864
139MP0001943_abnormal_respiration0.39942313
140MP0009780_abnormal_chondrocyte_physiolo0.39860279
141MP0004019_abnormal_vitamin_homeostasis0.37955588
142MP0003633_abnormal_nervous_system0.36424088
143MP0004742_abnormal_vestibular_system0.36216735
144MP0003635_abnormal_synaptic_transmissio0.34868317
145MP0000026_abnormal_inner_ear0.34019670
146MP0001324_abnormal_eye_pigmentation0.33897641
147MP0002735_abnormal_chemical_nociception0.33471658
148MP0002752_abnormal_somatic_nervous0.33345195
149MP0003329_amyloid_beta_deposits0.33192739

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.99539263
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28343565
3Abnormal respiratory epithelium morphology (HP:0012253)9.28343565
4Chronic bronchitis (HP:0004469)8.34061786
5Bronchiectasis (HP:0002110)5.70092985
6Nasal polyposis (HP:0100582)5.68069245
7Abnormality of the nasal mucosa (HP:0000433)4.78493240
8Bronchitis (HP:0012387)4.47844892
9Infertility (HP:0000789)4.47014271
10Nephronophthisis (HP:0000090)3.99837056
11Pancreatic fibrosis (HP:0100732)3.79811362
12Recurrent sinusitis (HP:0011108)3.53872857
13True hermaphroditism (HP:0010459)3.48286778
14Tubulointerstitial nephritis (HP:0001970)3.40404178
15Recurrent otitis media (HP:0000403)3.25477253
16Abnormality of midbrain morphology (HP:0002418)3.14081885
17Molar tooth sign on MRI (HP:0002419)3.14081885
18Abnormality of the renal medulla (HP:0100957)3.07567095
19Tubular atrophy (HP:0000092)2.99162835
20Chronic sinusitis (HP:0011109)2.97948378
21Medial flaring of the eyebrow (HP:0010747)2.94385591
22Cystic liver disease (HP:0006706)2.84785373
23Bile duct proliferation (HP:0001408)2.82924053
24Abnormal biliary tract physiology (HP:0012439)2.82924053
25Postaxial foot polydactyly (HP:0001830)2.75195778
26Pancreatic cysts (HP:0001737)2.68601075
27Occipital encephalocele (HP:0002085)2.61773837
28Congenital hepatic fibrosis (HP:0002612)2.55276434
29Supernumerary spleens (HP:0009799)2.49892843
30Median cleft lip (HP:0000161)2.49626552
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.48819099
32Abnormality of dentin (HP:0010299)2.46532185
33Chronic hepatic failure (HP:0100626)2.43470696
34Male infertility (HP:0003251)2.43189168
35Tubulointerstitial abnormality (HP:0001969)2.33674823
36Gait imbalance (HP:0002141)2.32627246
37Congenital primary aphakia (HP:0007707)2.30719739
38Stage 5 chronic kidney disease (HP:0003774)2.21499097
39Fibular hypoplasia (HP:0003038)2.18770390
40Chronic otitis media (HP:0000389)2.10203850
41Hyperactive renin-angiotensin system (HP:0000841)2.09200960
42Abnormality of permanent molar morphology (HP:0011071)2.03962420
43Abnormality of the dental root (HP:0006486)2.03962420
44Taurodontia (HP:0000679)2.03962420
45Nephrogenic diabetes insipidus (HP:0009806)2.01430472
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.5160031
47Abnormal respiratory motile cilium physiology (HP:0012261)11.7915409
48Abnormal ciliary motility (HP:0012262)10.3564289
49Dynein arm defect of respiratory motile cilia (HP:0012255)10.1793901
50Absent/shortened dynein arms (HP:0200106)10.1793901
51Anencephaly (HP:0002323)1.98855109
52Abnormal drinking behavior (HP:0030082)1.96878932
53Polydipsia (HP:0001959)1.96878932
54Oculomotor apraxia (HP:0000657)1.92542377
55Recurrent bronchitis (HP:0002837)1.90366962
56Abnormality of molar morphology (HP:0011070)1.90227041
57Abnormality of molar (HP:0011077)1.90227041
58Genital tract atresia (HP:0001827)1.89307045
59Postaxial hand polydactyly (HP:0001162)1.88179865
60Abnormality of the renal cortex (HP:0011035)1.86432386
61Abnormality of the dental pulp (HP:0006479)1.85843080
62Broad distal phalanx of finger (HP:0009836)1.79103807
63Aplasia/Hypoplasia of the spleen (HP:0010451)1.77903722
64Facial cleft (HP:0002006)1.76981233
65Preaxial hand polydactyly (HP:0001177)1.70376295
66Vaginal atresia (HP:0000148)1.68678720
67Sclerocornea (HP:0000647)1.67983248
68Asplenia (HP:0001746)1.67033047
69Poor coordination (HP:0002370)1.63637484
70Male pseudohermaphroditism (HP:0000037)1.62347832
71Tubulointerstitial fibrosis (HP:0005576)1.60755774
72Renal salt wasting (HP:0000127)1.57904998
73Aplasia/Hypoplasia of the lens (HP:0008063)1.57228102
74Anophthalmia (HP:0000528)1.54799854
75Nephropathy (HP:0000112)1.54378735
76Bell-shaped thorax (HP:0001591)1.53753889
77Narrow forehead (HP:0000341)1.49214748
78Broad foot (HP:0001769)1.48409656
79Microglossia (HP:0000171)1.48003017
80Abnormality of abdominal situs (HP:0011620)1.44929432
81Abdominal situs inversus (HP:0003363)1.44929432
82Decreased circulating renin level (HP:0003351)1.44668759
83Short ribs (HP:0000773)1.40811126
84Septo-optic dysplasia (HP:0100842)1.39523581
85Abnormality of renal excretion (HP:0011036)1.37213522
86Prominent nasal bridge (HP:0000426)1.36011354
87Multicystic kidney dysplasia (HP:0000003)1.34855891
88Abnormality of the middle phalanges of the toes (HP:0010183)1.34730655
89Furrowed tongue (HP:0000221)1.34494943
90Aganglionic megacolon (HP:0002251)1.34359470
91Polyphagia (HP:0002591)1.33644920
92Abnormal spermatogenesis (HP:0008669)1.33251561
93Retinitis pigmentosa (HP:0000510)1.32331506
94Holoprosencephaly (HP:0001360)1.31412296
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.31209084
96Renal dysplasia (HP:0000110)1.30816117
97Decreased testicular size (HP:0008734)1.27308125
98Optic nerve coloboma (HP:0000588)1.25280624
99Bifid scrotum (HP:0000048)1.24616269
100Short nail (HP:0001799)1.24307004
101Abnormal urine output (HP:0012590)1.23955575
102Sleep apnea (HP:0010535)1.23894904
103Polycystic kidney dysplasia (HP:0000113)1.23854667
104Hip dysplasia (HP:0001385)1.23467369
105Hyperaldosteronism (HP:0000859)1.22035927
106Labial hypoplasia (HP:0000066)1.21113446
107Abnormality of the labia minora (HP:0012880)1.20064802
108Chorioretinal coloboma (HP:0000567)1.19157544
109Polyuria (HP:0000103)1.19015235
110Short thorax (HP:0010306)1.17142726
111Decreased central vision (HP:0007663)1.15641830
112Hypodontia (HP:0000668)1.15388605
113Polycystic ovaries (HP:0000147)1.13070494
114Dyschromatopsia (HP:0007641)1.11178265
115Atelectasis (HP:0100750)1.08475705
116Gonadotropin excess (HP:0000837)1.06937082
117Abnormal sex determination (HP:0012244)1.03592009
118Sex reversal (HP:0012245)1.03592009
119Transposition of the great arteries (HP:0001669)1.03154927
120Abnormal connection of the cardiac segments (HP:0011545)1.03154927
121Abnormal ventriculo-arterial connection (HP:0011563)1.03154927
122Narrow chest (HP:0000774)1.02640111
123Neoplasm of head and neck (HP:0012288)1.02413700
124Esophageal neoplasm (HP:0100751)1.02413700
125Specific learning disability (HP:0001328)1.02391891
126Bifid tongue (HP:0010297)1.01572987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.97918197
2PDK36.41158165
3PDK46.41158165
4PNCK6.26193798
5TESK14.28201724
6PDK24.03712289
7PRKD33.44108480
8ICK2.67267712
9BCR2.37885195
10PTK2B2.33096877
11EPHA22.32704626
12EPHA32.26089604
13WNK32.04415819
14MAP4K21.92030162
15CASK1.87056349
16WNK41.78341495
17DYRK21.74809875
18STK391.73275889
19WEE11.72962522
20MKNK21.63958508
21STK161.52767394
22GRK11.40057882
23NME11.35107336
24EPHA41.34565346
25TSSK61.32892191
26EPHB21.26824878
27NTRK21.19976164
28STK381.16972734
29FGFR21.15898275
30CDK191.05508515
31NTRK31.05284929
32STK38L1.03688924
33DYRK31.01021768
34DYRK1B1.00244296
35ERBB30.96773050
36DYRK1A0.96657645
37CSNK1G20.92880377
38LMTK20.92455126
39STK240.92435018
40INSRR0.91638204
41TNIK0.91338353
42TRIM280.91311554
43NEK20.89815190
44MAPK130.89316903
45EPHB10.86266016
46ERBB20.83729983
47PRKCG0.83256374
48SIK10.82232695
49VRK10.81041937
50UHMK10.80855534
51IRAK10.79968933
52MAP2K40.79143544
53PAK20.78648036
54MST40.76252997
55CDK30.76214064
56TLK10.75200317
57WNK10.73785714
58PAK30.71360525
59PLK20.70947720
60SGK4940.69656760
61MKNK10.69053260
62FRK0.65557088
63MINK10.65259690
64PDK10.63845697
65LATS10.63207087
66STK30.61460585
67CSNK1G10.61035300
68MAPKAPK50.61002590
69LRRK20.60983764
70LIMK10.60838081
71MAPKAPK30.57058974
72CSNK1G30.56429637
73TTK0.55865076
74DMPK0.55516526
75PRKCI0.53921429
76MAP3K20.53587940
77PLK10.51990674
78STK100.51787554
79PINK10.50796176
80ZAK0.50088239
81PLK40.48428133
82CSNK1A1L0.47918285
83TYRO30.47358946
84CAMKK10.45873233
85MAP3K70.43864365
86BMPR1B0.41205322
87ADRBK10.40881921
88CDK50.39384164
89OXSR10.39357528
90SGK20.38318563
91SGK10.37540056
92MAP2K70.37331516
93GSK3A0.37293122
94SIK20.36397170
95NEK60.35689469
96CSNK1A10.34100477
97CHEK20.32773825
98AURKA0.31968916
99MUSK0.31301461
100CAMK1G0.31043084
101CSK0.30934085
102CAMK2G0.30330927
103TGFBR10.29648786
104MAP2K20.27501189
105PDPK10.27418325
106RPS6KA20.26159199
107GRK50.26027487
108DAPK20.25505729
109CAMK2A0.25028173
110PHKG10.24164242
111PHKG20.24164242
112ATM0.24078843
113PRKG10.23426050
114MARK10.22963822
115TIE10.21941874
116MARK20.20144078
117TEC0.19891359
118PRKACG0.17318232
119PAK10.16951838
120ADRBK20.16924263
121MAP3K40.16607276
122ROCK20.16360375
123PRKACA0.16300139
124PRKDC0.15999305
125ROCK10.15070339
126PKN10.14517067
127CSNK1E0.14417231
128SRC0.14091897
129ITK0.13942127
130PRKACB0.13554524
131GRK70.12477390
132STK110.11543927
133PRKCZ0.10889638
134RPS6KA50.10719762
135CDK80.09793017
136TESK20.09704365
137PRKCA0.09680509
138PASK0.09650932
139CSNK2A10.09410344
140BRSK20.09376236
141PRKCQ0.08411864
142CDK90.08145029
143PLK30.08143993
144EGFR0.08034168
145PRKCH0.07796951
146CHEK10.07298590
147CAMKK20.06309873
148RPS6KA10.06087724
149FER0.05200155
150CAMK2B0.05149585
151NLK0.04670331
152PRKCE0.04342438
153SGK2230.04307269

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.72632789
2Pyruvate metabolism_Homo sapiens_hsa006202.86339948
3Fatty acid biosynthesis_Homo sapiens_hsa000612.72665509
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72316845
5Phenylalanine metabolism_Homo sapiens_hsa003602.63660245
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.60286455
7Huntingtons disease_Homo sapiens_hsa050162.55887326
8beta-Alanine metabolism_Homo sapiens_hsa004102.27661549
9Propanoate metabolism_Homo sapiens_hsa006402.25188733
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16670925
11PPAR signaling pathway_Homo sapiens_hsa033202.16437311
12Tyrosine metabolism_Homo sapiens_hsa003502.13737416
13Dorso-ventral axis formation_Homo sapiens_hsa043202.12579314
14Oxidative phosphorylation_Homo sapiens_hsa001902.09963123
15Linoleic acid metabolism_Homo sapiens_hsa005912.06665512
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04036310
17Glucagon signaling pathway_Homo sapiens_hsa049222.03787189
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01429325
19Amphetamine addiction_Homo sapiens_hsa050311.97842905
20Protein export_Homo sapiens_hsa030601.90582439
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86119598
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86083576
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80759081
24Basal transcription factors_Homo sapiens_hsa030221.66898541
25Parkinsons disease_Homo sapiens_hsa050121.66121238
26Steroid biosynthesis_Homo sapiens_hsa001001.64939639
27Glycerolipid metabolism_Homo sapiens_hsa005611.64490039
28Hedgehog signaling pathway_Homo sapiens_hsa043401.58281788
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55586265
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55396957
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.54828900
32Mineral absorption_Homo sapiens_hsa049781.54823244
33Caffeine metabolism_Homo sapiens_hsa002321.54438535
34Glutathione metabolism_Homo sapiens_hsa004801.47291932
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.43391348
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38700466
37Gastric acid secretion_Homo sapiens_hsa049711.38317087
38Ether lipid metabolism_Homo sapiens_hsa005651.37962164
39Chemical carcinogenesis_Homo sapiens_hsa052041.37912982
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37441604
41Renin secretion_Homo sapiens_hsa049241.32348841
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29576213
43Tight junction_Homo sapiens_hsa045301.29140124
44Cardiac muscle contraction_Homo sapiens_hsa042601.26826587
45Pentose phosphate pathway_Homo sapiens_hsa000301.26676804
46Selenocompound metabolism_Homo sapiens_hsa004501.26515071
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25604985
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17803280
49Axon guidance_Homo sapiens_hsa043601.17663587
50Estrogen signaling pathway_Homo sapiens_hsa049151.16964576
51Alzheimers disease_Homo sapiens_hsa050101.15883384
52Fanconi anemia pathway_Homo sapiens_hsa034601.12242414
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12061150
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.11367803
55Basal cell carcinoma_Homo sapiens_hsa052171.09172042
56Taste transduction_Homo sapiens_hsa047421.09071952
57Purine metabolism_Homo sapiens_hsa002301.08429406
58Ribosome_Homo sapiens_hsa030101.07749471
59Insulin secretion_Homo sapiens_hsa049111.02345728
60Arachidonic acid metabolism_Homo sapiens_hsa005900.97287791
61Oocyte meiosis_Homo sapiens_hsa041140.96297269
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95128297
63Calcium signaling pathway_Homo sapiens_hsa040200.94365768
64Cocaine addiction_Homo sapiens_hsa050300.94228030
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92657460
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91542749
67Antigen processing and presentation_Homo sapiens_hsa046120.90737213
68Notch signaling pathway_Homo sapiens_hsa043300.90715032
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.89850338
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88736135
71Thyroid hormone synthesis_Homo sapiens_hsa049180.88575981
72Olfactory transduction_Homo sapiens_hsa047400.85260209
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83435818
74Retinol metabolism_Homo sapiens_hsa008300.82814420
75Nicotine addiction_Homo sapiens_hsa050330.82144950
76Wnt signaling pathway_Homo sapiens_hsa043100.80999888
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78606013
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78410933
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77022304
80Butanoate metabolism_Homo sapiens_hsa006500.75696809
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75388886
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74955766
83Circadian entrainment_Homo sapiens_hsa047130.72975642
84Nitrogen metabolism_Homo sapiens_hsa009100.72244451
85Histidine metabolism_Homo sapiens_hsa003400.72149013
86Fatty acid degradation_Homo sapiens_hsa000710.70576978
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.70331344
88Arginine and proline metabolism_Homo sapiens_hsa003300.67754622
89Folate biosynthesis_Homo sapiens_hsa007900.67436798
90Sphingolipid metabolism_Homo sapiens_hsa006000.67417828
91Fat digestion and absorption_Homo sapiens_hsa049750.66998901
92Tryptophan metabolism_Homo sapiens_hsa003800.66911120
93Serotonergic synapse_Homo sapiens_hsa047260.66807372
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66613692
95Bile secretion_Homo sapiens_hsa049760.66208268
96Salivary secretion_Homo sapiens_hsa049700.66051551
97Systemic lupus erythematosus_Homo sapiens_hsa053220.66016742
98Fructose and mannose metabolism_Homo sapiens_hsa000510.64425763
99Glutamatergic synapse_Homo sapiens_hsa047240.64420358
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64205260
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.64013514
102Fatty acid metabolism_Homo sapiens_hsa012120.63523157
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63109337
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.62467368
105cAMP signaling pathway_Homo sapiens_hsa040240.61162257
106Long-term potentiation_Homo sapiens_hsa047200.60995513
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59489704
108Collecting duct acid secretion_Homo sapiens_hsa049660.58718819
109ABC transporters_Homo sapiens_hsa020100.56525223
110Circadian rhythm_Homo sapiens_hsa047100.54483180
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54167285
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.53588229
113Ovarian steroidogenesis_Homo sapiens_hsa049130.53383355
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53127079
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52924655
116Regulation of autophagy_Homo sapiens_hsa041400.52898959
117Carbon metabolism_Homo sapiens_hsa012000.49483861
118Phototransduction_Homo sapiens_hsa047440.48732893
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45325037
120Alcoholism_Homo sapiens_hsa050340.42982927
121Pancreatic secretion_Homo sapiens_hsa049720.41995503
122TGF-beta signaling pathway_Homo sapiens_hsa043500.40883538
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39354764
124Protein digestion and absorption_Homo sapiens_hsa049740.38422835
125Starch and sucrose metabolism_Homo sapiens_hsa005000.38261164
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37679891
127Metabolic pathways_Homo sapiens_hsa011000.37483652
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35851307
129Sulfur metabolism_Homo sapiens_hsa009200.35659292
130AMPK signaling pathway_Homo sapiens_hsa041520.35621250
131Synaptic vesicle cycle_Homo sapiens_hsa047210.35345925
132Adherens junction_Homo sapiens_hsa045200.35165857
133Hippo signaling pathway_Homo sapiens_hsa043900.34676979
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33543997
135Melanogenesis_Homo sapiens_hsa049160.33144128
136RNA polymerase_Homo sapiens_hsa030200.32482397
137Gap junction_Homo sapiens_hsa045400.31720202
138Inositol phosphate metabolism_Homo sapiens_hsa005620.31361212
139Oxytocin signaling pathway_Homo sapiens_hsa049210.30566904
140Peroxisome_Homo sapiens_hsa041460.30248263
141Vitamin digestion and absorption_Homo sapiens_hsa049770.29887883
142Nucleotide excision repair_Homo sapiens_hsa034200.28635393
143GABAergic synapse_Homo sapiens_hsa047270.28415784
144Morphine addiction_Homo sapiens_hsa050320.27604955
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27359445
146Dopaminergic synapse_Homo sapiens_hsa047280.26869340

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