DNASE1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a deoxyribonuclease protein that shows high sequence similarity to DNase I. The encoded protein is localized to the endoplasmic reticulum and modified by N-linked glycosylation. Alternate transcriptional splice variants encoding the same protein have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.74814966
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.74814966
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.74814966
4modulation by symbiont of host immune response (GO:0052553)6.74814966
5positive regulation by symbiont of host defense response (GO:0052509)6.74814966
6modulation by symbiont of host defense response (GO:0052031)6.74814966
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.20082782
8neutrophil activation involved in immune response (GO:0002283)5.63619695
9regulation of interferon-beta biosynthetic process (GO:0045357)5.45135370
10macrophage activation involved in immune response (GO:0002281)4.89213558
11positive regulation of interferon-alpha production (GO:0032727)4.86476592
12regulation of interferon-alpha production (GO:0032647)4.59200031
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.59052799
14immunoglobulin mediated immune response (GO:0016064)4.50362125
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.45135086
16response to host immune response (GO:0052572)4.45135086
17response to peptidoglycan (GO:0032494)4.24383922
18respiratory burst (GO:0045730)4.03367903
19microglial cell activation (GO:0001774)3.98142006
20response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95829077
21response to host (GO:0075136)3.95829077
22response to host defenses (GO:0052200)3.95829077
23natural killer cell mediated cytotoxicity (GO:0042267)3.79051712
24natural killer cell mediated immunity (GO:0002228)3.79051712
25granulocyte activation (GO:0036230)3.75591922
26neutrophil activation (GO:0042119)3.72313943
27myeloid cell activation involved in immune response (GO:0002275)3.71566858
28actin-myosin filament sliding (GO:0033275)3.69349299
29muscle filament sliding (GO:0030049)3.69349299
30positive regulation of antigen processing and presentation (GO:0002579)3.62493675
31negative regulation of erythrocyte differentiation (GO:0045647)3.61923247
32macrophage activation (GO:0042116)3.50847938
33lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49990768
34skeletal muscle contraction (GO:0003009)3.47679257
35positive regulation of interferon-beta production (GO:0032728)3.46761533
36pinocytosis (GO:0006907)3.43590428
37production of molecular mediator involved in inflammatory response (GO:0002532)3.42083343
38detection of molecule of bacterial origin (GO:0032490)3.41165131
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37788162
40B cell mediated immunity (GO:0019724)3.36888838
41negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.36753125
42positive regulation of mast cell activation (GO:0033005)3.35234383
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31844716
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31844716
45hydrogen peroxide biosynthetic process (GO:0050665)3.31599633
46positive regulation of gamma-delta T cell activation (GO:0046645)3.31255139
47regulation of B cell receptor signaling pathway (GO:0050855)3.30647447
48regulation of mononuclear cell migration (GO:0071675)3.28696606
49antigen processing and presentation of endogenous antigen (GO:0019883)3.27184268
50regulation of interleukin-8 biosynthetic process (GO:0045414)3.27002870
51barbed-end actin filament capping (GO:0051016)3.23872046
52sarcoplasmic reticulum calcium ion transport (GO:0070296)3.23241862
53positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.22840980
54negative regulation of cell killing (GO:0031342)3.21394452
55negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.21394452
56I-kappaB phosphorylation (GO:0007252)3.19906820
57regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.17547935
58response to muramyl dipeptide (GO:0032495)3.16254683
59protein localization to endosome (GO:0036010)3.15049028
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14823752
61negative regulation of interleukin-12 production (GO:0032695)3.11869467
62regulation of mast cell degranulation (GO:0043304)3.06723930
63superoxide anion generation (GO:0042554)3.05972909
64T-helper 1 type immune response (GO:0042088)3.05963832
65positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.02404834
66regulation of antigen processing and presentation (GO:0002577)3.01710749
67positive regulation of natural killer cell differentiation (GO:0032825)3.00982636
68detection of other organism (GO:0098543)3.00310447
69reactive oxygen species biosynthetic process (GO:1903409)3.00247128
70cellular response to thyroid hormone stimulus (GO:0097067)2.99753259
71actin-mediated cell contraction (GO:0070252)2.99236826
72positive regulation of mast cell activation involved in immune response (GO:0033008)2.98445913
73positive regulation of mast cell degranulation (GO:0043306)2.98445913
74leukocyte mediated cytotoxicity (GO:0001909)2.98437263
75germinal center formation (GO:0002467)2.97708228
76cellular extravasation (GO:0045123)2.97470775
77regulation of mast cell activation (GO:0033003)2.96152697
78negative regulation of interleukin-17 production (GO:0032700)2.96083860
79regulation of skeletal muscle contraction (GO:0014819)2.95077007
80neutrophil mediated immunity (GO:0002446)2.91892094
81positive regulation of chemokine biosynthetic process (GO:0045080)2.90868889
82interferon-gamma-mediated signaling pathway (GO:0060333)2.89759481
83positive regulation of cellular amide metabolic process (GO:0034250)2.89123773
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88850882
85negative regulation of mast cell activation (GO:0033004)2.87059267
86positive regulation of B cell differentiation (GO:0045579)2.86546402
87skeletal muscle adaptation (GO:0043501)2.85466631
88regulation of mast cell activation involved in immune response (GO:0033006)2.84761500
89type I interferon signaling pathway (GO:0060337)2.84473782
90cellular response to type I interferon (GO:0071357)2.84473782
91response to type I interferon (GO:0034340)2.83133112
92regulation of cholesterol storage (GO:0010885)2.82296337
93positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.82077988
94positive regulation of receptor recycling (GO:0001921)2.81943897
95positive regulation of leukocyte degranulation (GO:0043302)2.81409696
96mannose metabolic process (GO:0006013)2.80933848
97myeloid leukocyte activation (GO:0002274)2.79834127
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78638643
99positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76197820
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75941167
101regulation of necroptotic process (GO:0060544)2.75066874
102detection of bacterium (GO:0016045)2.74382534
103monocyte chemotaxis (GO:0002548)2.74226216
104response to interferon-alpha (GO:0035455)2.73446266
105detection of external biotic stimulus (GO:0098581)2.73268173
106regulation of interleukin-12 biosynthetic process (GO:0045075)2.71280054
107regulation of T-helper 2 cell differentiation (GO:0045628)2.69609503
108stress fiber assembly (GO:0043149)2.68616890
109negative regulation of necroptotic process (GO:0060546)2.67838641
110lymphocyte mediated immunity (GO:0002449)2.66811673
111lymphocyte chemotaxis (GO:0048247)2.65951984
112regulation of leukocyte degranulation (GO:0043300)2.65341433
113response to thyroid hormone (GO:0097066)2.63501832
114cellular response to interferon-beta (GO:0035458)2.63460421
115actin filament-based movement (GO:0030048)2.62414055
116myeloid dendritic cell activation (GO:0001773)2.61346676
117myeloid dendritic cell differentiation (GO:0043011)2.60400243
118cytidine deamination (GO:0009972)2.59974037
119cytidine metabolic process (GO:0046087)2.59974037
120cytidine catabolic process (GO:0006216)2.59974037
121defense response to protozoan (GO:0042832)2.59173079
122response to laminar fluid shear stress (GO:0034616)2.57694223
123leukocyte aggregation (GO:0070486)2.57606560
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.57130948
125glycosphingolipid catabolic process (GO:0046479)2.55145655
126response to interferon-beta (GO:0035456)2.54829532
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.47817410
128positive regulation of myotube differentiation (GO:0010831)2.46222778
129regulation of membrane protein ectodomain proteolysis (GO:0051043)2.42658223
130regulation of macrophage cytokine production (GO:0010935)2.41857248
131Golgi transport vesicle coating (GO:0048200)2.41661008
132COPI coating of Golgi vesicle (GO:0048205)2.41661008
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41425956
134hypotonic response (GO:0006971)2.40149435
135regulation of necrotic cell death (GO:0010939)2.39466022
136regulation of early endosome to late endosome transport (GO:2000641)2.34638198
137detection of biotic stimulus (GO:0009595)2.34347973
138regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34058925
139regulation of gamma-delta T cell activation (GO:0046643)2.32307850
140positive regulation of blood vessel endothelial cell migration (GO:0043536)2.30768570
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.27684879
142cell-substrate junction assembly (GO:0007044)2.26254121
143cell adhesion mediated by integrin (GO:0033627)2.24988570
144glycolipid catabolic process (GO:0019377)2.23701159
145negative regulation of homotypic cell-cell adhesion (GO:0034111)2.23602333
146negative regulation of cell size (GO:0045792)2.21556777
147negative regulation of cytokine production involved in immune response (GO:0002719)2.21551298
148hyaluronan catabolic process (GO:0030214)2.20928920
149sarcomere organization (GO:0045214)2.20031294
150apoptotic cell clearance (GO:0043277)2.17720653
151modulation by symbiont of host cellular process (GO:0044068)2.17419103
152peptide catabolic process (GO:0043171)2.17409560
153NIK/NF-kappaB signaling (GO:0038061)2.16970074
154regulation of platelet aggregation (GO:0090330)2.16774048
155pentose-phosphate shunt (GO:0006098)2.15803560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.24012615
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.06459977
3IRF8_21731497_ChIP-ChIP_J774_Mouse6.02291761
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.13009269
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.97899104
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58922352
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.55155618
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39255171
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25711991
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19188999
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12943220
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02478117
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.68756542
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.59715493
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56098294
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35676588
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35332795
18LXR_22292898_ChIP-Seq_THP-1_Human2.29951263
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.29488636
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21537424
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20377624
22* SPI1_23547873_ChIP-Seq_NB4_Human2.14161776
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09331941
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.07248421
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.01162037
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99064325
27* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93142543
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.89383179
29RACK7_27058665_Chip-Seq_MCF-7_Human1.88934092
30SCL_19346495_ChIP-Seq_HPC-7_Human1.88557197
31PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.87012677
32KDM2B_26808549_Chip-Seq_DND41_Human1.85023314
33MYC_22102868_ChIP-Seq_BL_Human1.84847188
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84248985
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79380168
36PU_27001747_Chip-Seq_BMDM_Mouse1.77578068
37GATA1_22025678_ChIP-Seq_K562_Human1.75766363
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75718132
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.75696592
40VDR_24763502_ChIP-Seq_THP-1_Human1.73943406
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69954671
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69494645
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63956367
44* SPI1_23127762_ChIP-Seq_K562_Human1.63830056
45VDR_24787735_ChIP-Seq_THP-1_Human1.61639225
46MAF_26560356_Chip-Seq_TH1_Human1.59138237
47MYB_26560356_Chip-Seq_TH2_Human1.58381045
48RUNX_20019798_ChIP-Seq_JUKART_Human1.55336254
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.51579851
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50553636
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50537330
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48921575
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48033875
54VDR_21846776_ChIP-Seq_THP-1_Human1.43489212
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43279824
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42978683
57CLOCK_20551151_ChIP-Seq_293T_Human1.41920344
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41282361
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40898907
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40157916
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38571526
62CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35679158
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35328277
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34848120
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34621415
66MYB_26560356_Chip-Seq_TH1_Human1.33942296
67ZNF263_19887448_ChIP-Seq_K562_Human1.31859922
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31501774
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30151333
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28016412
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27937901
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.27829542
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.27829542
74* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27780666
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.27672487
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25835433
77KDM2B_26808549_Chip-Seq_K562_Human1.24137476
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23777383
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.23298047
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21823602
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.21524429
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21129919
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19845906
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19352520
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.16753567
86TFEB_21752829_ChIP-Seq_HELA_Human1.16445852
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15674244
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14741017
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14392128
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.13113303
91NCOR1_26117541_ChIP-Seq_K562_Human1.12796816
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10509260
93GATA3_26560356_Chip-Seq_TH2_Human1.10251390
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.09627858
95GATA3_27048872_Chip-Seq_THYMUS_Human1.09595714
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08848828
97UTX_26944678_Chip-Seq_JUKART_Human1.07688428
98ATF3_27146783_Chip-Seq_COLON_Human1.07348576
99SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07122017
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05217949
101* P68_20966046_ChIP-Seq_HELA_Human1.04224564
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04067012
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03974635
104* BCOR_27268052_Chip-Seq_Bcells_Human1.03821953
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03694261
106TCF7_22412390_ChIP-Seq_EML_Mouse1.03528508
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03350832
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02012721
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.02002762
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.01366344
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.01024744
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00050902
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99631636
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.94335072
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94183517
116GATA1_19941826_ChIP-Seq_K562_Human0.92916091
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92493785
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92493785
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92250900
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91492934
121GATA2_19941826_ChIP-Seq_K562_Human0.91222225
122* SOX2_20726797_ChIP-Seq_SW620_Human0.88042778
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87925005
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87251368
125CJUN_26792858_Chip-Seq_BT549_Human0.87237250
126RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84701950
127MAF_26560356_Chip-Seq_TH2_Human0.84442916
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81497439
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80533301
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80479829
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79554494
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79554494
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79419570
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78710973
135JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78475648
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77635547
137CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.77472269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.14825601
2MP0005451_abnormal_body_composition3.79461010
3MP0005058_abnormal_lysosome_morphology3.74246363
4MP0003436_decreased_susceptibility_to3.70425793
5MP0002148_abnormal_hypersensitivity_rea2.99632729
6MP0002419_abnormal_innate_immunity2.93836377
7MP0009785_altered_susceptibility_to2.91952414
8MP0005000_abnormal_immune_tolerance2.77256203
9MP0006082_CNS_inflammation2.73801476
10MP0003724_increased_susceptibility_to2.72929360
11MP0000751_myopathy2.64102194
12MP0003303_peritoneal_inflammation2.62942067
13MP0005025_abnormal_response_to2.56387788
14MP0001790_abnormal_immune_system2.39608098
15MP0005387_immune_system_phenotype2.39608098
16MP0002452_abnormal_antigen_presenting2.36321375
17MP0000685_abnormal_immune_system2.33347922
18MP0003172_abnormal_lysosome_physiology2.23935893
19MP0001800_abnormal_humoral_immune2.21351981
20MP0002723_abnormal_immune_serum2.14929075
21MP0005671_abnormal_response_to2.10288442
22MP0001533_abnormal_skeleton_physiology2.08314279
23MP0004510_myositis2.06756642
24MP0005464_abnormal_platelet_physiology2.03762507
25MP0009840_abnormal_foam_cell1.99064591
26MP0001819_abnormal_immune_cell1.96201320
27MP0002420_abnormal_adaptive_immunity1.94368053
28MP0000343_altered_response_to1.87010107
29MP0001853_heart_inflammation1.83328266
30MP0004036_abnormal_muscle_relaxation1.81074516
31MP0000747_muscle_weakness1.81023470
32MP0002166_altered_tumor_susceptibility1.78454165
33MP0002405_respiratory_system_inflammati1.75549365
34MP0003191_abnormal_cellular_cholesterol1.69222369
35MP0003448_altered_tumor_morphology1.66987203
36MP0004233_abnormal_muscle_weight1.65841639
37MP0000759_abnormal_skeletal_muscle1.65401845
38MP0001845_abnormal_inflammatory_respons1.64843123
39MP0000569_abnormal_digit_pigmentation1.63574736
40MP0008260_abnormal_autophagy1.63436254
41MP0002006_tumorigenesis1.60014079
42MP0004947_skin_inflammation1.58395413
43MP0003828_pulmonary_edema1.58164824
44MP0009764_decreased_sensitivity_to1.57612425
45MP0008469_abnormal_protein_level1.51731172
46MP0004087_abnormal_muscle_fiber1.51629439
47MP0003656_abnormal_erythrocyte_physiolo1.50938983
48MP0003091_abnormal_cell_migration1.47353837
49MP0003300_gastrointestinal_ulcer1.40532186
50MP0009278_abnormal_bone_marrow1.40017409
51MP0001849_ear_inflammation1.39529574
52MP0010155_abnormal_intestine_physiology1.38894384
53MP0000716_abnormal_immune_system1.38873192
54MP0002998_abnormal_bone_remodeling1.38685541
55MP0001545_abnormal_hematopoietic_system1.38061337
56MP0005397_hematopoietic_system_phenotyp1.38061337
57MP0004145_abnormal_muscle_electrophysio1.37472557
58MP0003075_altered_response_to1.36687084
59MP0004084_abnormal_cardiac_muscle1.36659344
60MP0005310_abnormal_salivary_gland1.35965729
61MP0005330_cardiomyopathy1.32354322
62MP0000858_altered_metastatic_potential1.30040968
63MP0002398_abnormal_bone_marrow1.28734534
64MP0000749_muscle_degeneration1.27141845
65MP0000689_abnormal_spleen_morphology1.25108384
66MP0005167_abnormal_blood-brain_barrier1.22677764
67MP0000604_amyloidosis1.21525723
68MP0003453_abnormal_keratinocyte_physiol1.20781632
69MP0003690_abnormal_glial_cell1.18521068
70MP0002429_abnormal_blood_cell1.16720192
71MP0005166_decreased_susceptibility_to1.16254817
72MP0009333_abnormal_splenocyte_physiolog1.15604763
73MP0005174_abnormal_tail_pigmentation1.15447308
74MP0003186_abnormal_redox_activity1.14905215
75MP0010307_abnormal_tumor_latency1.14421815
76MP0003566_abnormal_cell_adhesion1.13263309
77MP0002269_muscular_atrophy1.12669580
78MP0002722_abnormal_immune_system1.10229578
79MP0005023_abnormal_wound_healing1.08793423
80MP0002933_joint_inflammation1.05838555
81MP0004130_abnormal_muscle_cell1.05657785
82MP0005369_muscle_phenotype1.02190979
83MP0005390_skeleton_phenotype1.00745649
84MP0002254_reproductive_system_inflammat0.99356982
85MP0001542_abnormal_bone_strength0.98516374
86MP0005257_abnormal_intraocular_pressure0.98380215
87MP0005165_increased_susceptibility_to0.98380140
88MP0008438_abnormal_cutaneous_collagen0.98242161
89MP0003646_muscle_fatigue0.96506195
90MP0000249_abnormal_blood_vessel0.96326566
91MP0000465_gastrointestinal_hemorrhage0.96071982
92MP0002972_abnormal_cardiac_muscle0.95283893
93MP0004272_abnormal_basement_membrane0.93922581
94MP0005620_abnormal_muscle_contractility0.92809851
95MP0001851_eye_inflammation0.91366388
96MP0005164_abnormal_response_to0.90730588
97MP0006138_congestive_heart_failure0.90569757
98MP0004858_abnormal_nervous_system0.90371515
99MP0002138_abnormal_hepatobiliary_system0.90078584
100MP0000750_abnormal_muscle_regeneration0.89048319
101MP0009763_increased_sensitivity_to0.88745431
102MP0004782_abnormal_surfactant_physiolog0.88065014
103MP0005666_abnormal_adipose_tissue0.85895904
104MP0010630_abnormal_cardiac_muscle0.83786238
105MP0003183_abnormal_peptide_metabolism0.81829052
106MP0005375_adipose_tissue_phenotype0.81184292
107MP0003705_abnormal_hypodermis_morpholog0.80978422
108MP0001873_stomach_inflammation0.80303405
109MP0002009_preneoplasia0.79933692
110MP0000767_abnormal_smooth_muscle0.79643046
111MP0003763_abnormal_thymus_physiology0.79414661
112MP0003045_fibrosis0.79358069
113MP0008004_abnormal_stomach_pH0.79330919
114MP0002332_abnormal_exercise_endurance0.78956814
115MP0004883_abnormal_blood_vessel0.78450979
116MP0003195_calcinosis0.77164646
117MP0002277_abnormal_respiratory_mucosa0.77059555
118MP0002877_abnormal_melanocyte_morpholog0.76684037
119MP0003795_abnormal_bone_structure0.75086396
120MP0002106_abnormal_muscle_physiology0.74974288
121MP0002396_abnormal_hematopoietic_system0.73468134
122MP0004185_abnormal_adipocyte_glucose0.71095650
123MP0001958_emphysema0.71061933
124MP0000733_abnormal_muscle_development0.69038714
125MP0003950_abnormal_plasma_membrane0.68837376
126MP0002136_abnormal_kidney_physiology0.68377780
127MP0005076_abnormal_cell_differentiation0.68305254
128MP0006054_spinal_hemorrhage0.68277083
129MP0000371_diluted_coat_color0.67255235
130MP0000490_abnormal_crypts_of0.66722862
131MP0003279_aneurysm0.66309386

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.68442266
2Recurrent bacterial skin infections (HP:0005406)5.84565795
3Eczematoid dermatitis (HP:0000976)5.52555666
4Increased cerebral lipofuscin (HP:0011813)5.24060329
5Vacuolated lymphocytes (HP:0001922)5.19631498
6Recurrent gram-negative bacterial infections (HP:0005420)5.04687256
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.72384914
8Abnormality of macrophages (HP:0004311)4.70715549
9Autoimmune thrombocytopenia (HP:0001973)4.38597239
10Systemic lupus erythematosus (HP:0002725)4.05842116
11Axonal loss (HP:0003447)3.96090376
12Abnormality of liposaccharide metabolism (HP:0010968)3.77579051
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.77579051
14Abnormality of glycolipid metabolism (HP:0010969)3.77579051
15Distal lower limb muscle weakness (HP:0009053)3.65681922
16Myositis (HP:0100614)3.54691414
17Recurrent skin infections (HP:0001581)3.52899633
18Mediastinal lymphadenopathy (HP:0100721)3.52499841
19Abnormality of skeletal muscle fiber size (HP:0012084)3.51832885
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.50776412
21Disinhibition (HP:0000734)3.48464503
22Elevated erythrocyte sedimentation rate (HP:0003565)3.36399759
23Dysostosis multiplex (HP:0000943)3.32517294
24Gingivitis (HP:0000230)3.32025181
25Exercise-induced muscle cramps (HP:0003710)3.29464010
26Obstructive lung disease (HP:0006536)3.27926440
27Chronic obstructive pulmonary disease (HP:0006510)3.27926440
28Increased variability in muscle fiber diameter (HP:0003557)3.24715458
29Orchitis (HP:0100796)3.19922685
30Round ear (HP:0100830)3.09321792
31Recurrent fungal infections (HP:0002841)3.04352419
32Muscle fiber splitting (HP:0003555)3.02498178
33Distal lower limb amyotrophy (HP:0008944)3.01817800
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01443121
35Hyporeflexia of lower limbs (HP:0002600)2.93852241
36EMG: myopathic abnormalities (HP:0003458)2.90444166
37Muscle fiber inclusion bodies (HP:0100299)2.89445333
38Protrusio acetabuli (HP:0003179)2.88878679
39Pustule (HP:0200039)2.86546842
40Urinary glycosaminoglycan excretion (HP:0003541)2.81454790
41Mucopolysacchariduria (HP:0008155)2.81454790
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.78688273
43Recurrent viral infections (HP:0004429)2.78105747
44Retrobulbar optic neuritis (HP:0100654)2.76488500
45Optic neuritis (HP:0100653)2.76488500
46Premature rupture of membranes (HP:0001788)2.75325395
47Loss of speech (HP:0002371)2.75322148
48Glomerulonephritis (HP:0000099)2.74212870
49Myocardial infarction (HP:0001658)2.72344939
50Ulnar deviation of the wrist (HP:0003049)2.71546586
51Abnormality of polysaccharide metabolism (HP:0011012)2.69252859
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69252859
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69252859
54Basal ganglia calcification (HP:0002135)2.69017131
55Urticaria (HP:0001025)2.67487006
56Petechiae (HP:0000967)2.67443427
57Rhabdomyolysis (HP:0003201)2.65963637
58Nemaline bodies (HP:0003798)2.65787356
59Stomatitis (HP:0010280)2.65013078
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59495956
61Thick nail (HP:0001805)2.59176528
62Cellulitis (HP:0100658)2.58592896
63Osteolytic defects of the hand bones (HP:0009699)2.57397070
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.57397070
65Periodontitis (HP:0000704)2.54547982
66Spinal rigidity (HP:0003306)2.52240090
67Neck muscle weakness (HP:0000467)2.51507605
68Mildly elevated creatine phosphokinase (HP:0008180)2.49799209
69Interstitial pulmonary disease (HP:0006530)2.48634031
70Frequent falls (HP:0002359)2.48567427
71Bulbar palsy (HP:0001283)2.46517633
72Vasculitis (HP:0002633)2.45946943
73Asymmetric septal hypertrophy (HP:0001670)2.44138614
74Difficulty running (HP:0009046)2.43434203
75Agnosia (HP:0010524)2.42429884
76Tetraparesis (HP:0002273)2.41883455
77Prostate neoplasm (HP:0100787)2.38933685
78Osteomyelitis (HP:0002754)2.33735946
79Distal arthrogryposis (HP:0005684)2.32075304
80Nausea (HP:0002018)2.31915012
81Hepatosplenomegaly (HP:0001433)2.31359351
82Vertebral compression fractures (HP:0002953)2.31012877
83Slender build (HP:0001533)2.30240095
84Hematochezia (HP:0002573)2.29490873
85Difficulty climbing stairs (HP:0003551)2.24262271
86Chronic mucocutaneous candidiasis (HP:0002728)2.23181185
87Recurrent cutaneous fungal infections (HP:0011370)2.23181185
88Cerebral aneurysm (HP:0004944)2.22400963
89Nephritis (HP:0000123)2.18998341
90Pathologic fracture (HP:0002756)2.18777134
91Recurrent pneumonia (HP:0006532)2.16812140
92Myoglobinuria (HP:0002913)2.16068997
93Muscle hypertrophy of the lower extremities (HP:0008968)2.15489632
94Aortic aneurysm (HP:0004942)2.10779285
95Pulmonary infiltrates (HP:0002113)2.08351935
96Abnormality of the calf musculature (HP:0001430)2.07894121
97Achilles tendon contracture (HP:0001771)2.07737665
98Muscle stiffness (HP:0003552)2.07710382
99Meningitis (HP:0001287)2.05727154
100Spontaneous hematomas (HP:0007420)2.05376800
101Myopathic facies (HP:0002058)2.04657427
102Cervical subluxation (HP:0003308)2.04081925
103Exercise-induced myalgia (HP:0003738)2.01970531
104Increased serum ferritin (HP:0003281)2.01441707
105Chronic otitis media (HP:0000389)2.01209216
106Gingival bleeding (HP:0000225)2.00970777
107Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00937924
108Colitis (HP:0002583)2.00685513
109Leukocytosis (HP:0001974)1.99419054
110Purpura (HP:0000979)1.98210779
111Type 1 muscle fiber predominance (HP:0003803)1.97408435
112Poor head control (HP:0002421)1.95446915
113Spondylolisthesis (HP:0003302)1.92851700
114Polycythemia (HP:0001901)1.92616666
115Lower limb amyotrophy (HP:0007210)1.92064112
116Recurrent lower respiratory tract infections (HP:0002783)1.91101374
117Thin bony cortex (HP:0002753)1.91018863
118Bone pain (HP:0002653)1.90245059
119Joint stiffness (HP:0001387)1.89286485
120Fatigue (HP:0012378)1.89173072
121Increased connective tissue (HP:0009025)1.89125808
122Abnormality of the Achilles tendon (HP:0005109)1.87533847
123Peritonitis (HP:0002586)1.87269011
124Dilatation of the ascending aorta (HP:0005111)1.86162247
125Ventricular tachycardia (HP:0004756)1.85211623
126Calf muscle hypertrophy (HP:0008981)1.84478439
127Amyloidosis (HP:0011034)1.83379759
128Easy fatigability (HP:0003388)1.81233279
129Abnormality of the left ventricular outflow tract (HP:0011103)1.81215373
130Subaortic stenosis (HP:0001682)1.81215373
131Upper motor neuron abnormality (HP:0002127)1.79417959
132Joint hemorrhage (HP:0005261)1.79390802
133Inflammation of the large intestine (HP:0002037)1.78982348
134Epistaxis (HP:0000421)1.78553332
135Abnormality of complement system (HP:0005339)1.78504433
136Generalized amyotrophy (HP:0003700)1.78316779
137Vascular tortuosity (HP:0004948)1.78213389
138J-shaped sella turcica (HP:0002680)1.77518423
139Keratoconjunctivitis sicca (HP:0001097)1.77051655
140Arterial thrombosis (HP:0004420)1.76928138
141Abnormality of the lumbar spine (HP:0100712)1.75568069
142Abnormality of iron homeostasis (HP:0011031)1.74600886
143Progressive visual loss (HP:0000529)1.74562047
144Bone cyst (HP:0012062)1.73715460
145Arterial tortuosity (HP:0005116)1.72036056
146Scapular winging (HP:0003691)1.71948549
147Aneurysm (HP:0002617)1.71848920
148Malignant hyperthermia (HP:0002047)1.70642096
149Aortic dissection (HP:0002647)1.69759989
150Prolonged bleeding time (HP:0003010)1.68378298
151Chest pain (HP:0100749)1.65215530
152Generalized muscle weakness (HP:0003324)1.65080297
153Fragile skin (HP:0001030)1.64944997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.74828891
2MAP3K143.43663867
3TBK13.15565714
4TYK23.12657281
5KIT3.08611105
6RIPK42.74428358
7IRAK32.61953227
8TTN2.60918193
9IRAK42.59409558
10PRPF4B2.52913311
11MAP4K12.48255311
12PBK2.48019023
13IKBKE2.37555036
14NME22.37398258
15ERN12.34139677
16MAP2K32.17536576
17JAK32.08176523
18NEK92.07247133
19SIK12.04489676
20IKBKB2.03582505
21TGFBR21.78999859
22JAK11.68356092
23PIM21.67582454
24TRPM71.65701615
25OBSCN1.51066356
26TXK1.42581574
27ZAP701.36230570
28TEC1.35606393
29TAOK31.30661104
30TRIB31.30085947
31MAP3K31.29736757
32CSF1R1.28812695
33SYK1.27703955
34PIK3CG1.22250578
35CSK1.21937090
36BTK1.16301698
37HCK1.14661978
38TESK11.14566528
39SMG11.12423352
40ICK1.09965491
41MAP3K111.09239421
42STK101.07098987
43RIPK11.07053757
44TIE11.06757852
45KSR21.04569100
46RPS6KA41.04319489
47CHUK1.03799915
48JAK21.03223587
49TESK21.02064099
50LYN1.01853757
51PIM11.01650891
52LCK1.01563031
53ZAK1.00844974
54MATK1.00150487
55MUSK0.99721032
56EEF2K0.99225439
57MST40.98973662
58MAP3K130.98232752
59CDC42BPA0.97404030
60BMX0.95948200
61PDPK10.94865578
62MAP3K70.94475811
63ABL20.93142788
64PRKD20.92994426
65ARAF0.92900399
66LRRK20.91376652
67PDGFRA0.90146787
68DDR20.88879981
69CAMK1D0.88236649
70PKN20.84645582
71MAPKAPK30.83360647
72GRK60.83085362
73GRK70.82232478
74TNK20.81864538
75STK40.81549841
76EPHB10.80291576
77ERBB30.78937210
78IRAK20.76554102
79MARK20.75992651
80EPHA20.74895999
81MAP3K60.74656640
82LIMK10.73228310
83MAPK70.72022109
84SIK30.71482092
85RPS6KA20.70528180
86CDK60.68299771
87PTK60.66996805
88FLT30.66505461
89DMPK0.65395677
90EGFR0.64061831
91ITK0.63540407
92FGR0.63119903
93FES0.61035794
94PRKCD0.60948606
95ABL10.60066227
96RPS6KC10.59352351
97RPS6KL10.59352351
98MARK30.58516615
99PDK10.58091453
100STK240.57511914
101DYRK1B0.56710349
102MAPK120.56438712
103MAP3K50.56119329
104PTK20.56098325
105KDR0.54381474
106PIK3CA0.53399471
107TAOK20.53130453
108FGFR30.52772076
109MST1R0.50874035
110CLK10.49505843
111PTK2B0.49059178
112MAP2K60.47658379
113MAPKAPK20.47342560
114NUAK10.46338239
115MAP3K100.45850859
116EPHA30.45517499
117ILK0.43911719
118EPHB20.42558708
119EIF2AK20.42494874
120MTOR0.42168660
121BMPR20.41182623
122PAK40.40977077
123PRKD10.39405961
124TAOK10.38729824
125MOS0.38630341
126MAPK40.38452317
127PRKAA20.38161165
128STK30.37656076
129FGFR40.37577303
130LMTK20.36967682
131MAP2K10.36490544
132PRKG20.33150873
133RPS6KA60.32983128
134MAP3K10.32793288
135PHKG20.30708117
136PHKG10.30708117
137PRKCQ0.30137926
138MYLK0.29930009
139SCYL20.28320272
140CDK90.27668067
141MAPK110.27020737
142CAMK1G0.26705592

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.39432245
2Leishmaniasis_Homo sapiens_hsa051403.24067200
3Lysosome_Homo sapiens_hsa041422.95706761
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73182429
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.54832886
6Osteoclast differentiation_Homo sapiens_hsa043802.46097251
7Malaria_Homo sapiens_hsa051442.35703451
8Tuberculosis_Homo sapiens_hsa051522.34878947
9Other glycan degradation_Homo sapiens_hsa005112.34308250
10Legionellosis_Homo sapiens_hsa051342.30984199
11Pertussis_Homo sapiens_hsa051332.25115473
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.22853087
13Rheumatoid arthritis_Homo sapiens_hsa053232.01940978
14Graft-versus-host disease_Homo sapiens_hsa053322.00233720
15Phagosome_Homo sapiens_hsa041451.98312870
16Caffeine metabolism_Homo sapiens_hsa002321.97969750
17Measles_Homo sapiens_hsa051621.94169542
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91803552
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80259161
20Allograft rejection_Homo sapiens_hsa053301.71457411
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70326021
22B cell receptor signaling pathway_Homo sapiens_hsa046621.70177974
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.69187199
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68931430
25Influenza A_Homo sapiens_hsa051641.61793345
26Apoptosis_Homo sapiens_hsa042101.60642404
27Toxoplasmosis_Homo sapiens_hsa051451.59262530
28Asthma_Homo sapiens_hsa053101.58475779
29Antigen processing and presentation_Homo sapiens_hsa046121.58359298
30TNF signaling pathway_Homo sapiens_hsa046681.56443489
31Hematopoietic cell lineage_Homo sapiens_hsa046401.54397453
32Salmonella infection_Homo sapiens_hsa051321.53915563
33Pentose phosphate pathway_Homo sapiens_hsa000301.46941735
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41455032
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38319248
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30775783
37Viral myocarditis_Homo sapiens_hsa054161.30178157
38Bladder cancer_Homo sapiens_hsa052191.29295119
39Fructose and mannose metabolism_Homo sapiens_hsa000511.28633626
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.26986971
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24063477
42Herpes simplex infection_Homo sapiens_hsa051681.21659028
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.17400338
44Shigellosis_Homo sapiens_hsa051311.13063280
45Insulin signaling pathway_Homo sapiens_hsa049101.09718270
46Hepatitis B_Homo sapiens_hsa051611.08131277
47Chemokine signaling pathway_Homo sapiens_hsa040621.07779225
48Non-small cell lung cancer_Homo sapiens_hsa052231.03996063
49Amoebiasis_Homo sapiens_hsa051461.00778566
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00151484
51Complement and coagulation cascades_Homo sapiens_hsa046100.99743482
52Hepatitis C_Homo sapiens_hsa051600.95172636
53Renal cell carcinoma_Homo sapiens_hsa052110.92538003
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92307293
55Platelet activation_Homo sapiens_hsa046110.90618278
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90057557
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89648276
58Primary immunodeficiency_Homo sapiens_hsa053400.89201417
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88106882
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87584743
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85646165
62Sphingolipid metabolism_Homo sapiens_hsa006000.84516174
63African trypanosomiasis_Homo sapiens_hsa051430.81591898
64mTOR signaling pathway_Homo sapiens_hsa041500.81377262
65GnRH signaling pathway_Homo sapiens_hsa049120.79987305
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78876295
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77857715
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.77447011
69Notch signaling pathway_Homo sapiens_hsa043300.77164604
70Acute myeloid leukemia_Homo sapiens_hsa052210.76643710
71Autoimmune thyroid disease_Homo sapiens_hsa053200.72941345
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71578398
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69856692
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.69253026
75Chronic myeloid leukemia_Homo sapiens_hsa052200.67825331
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66141708
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.65165484
78Endometrial cancer_Homo sapiens_hsa052130.64751266
79Pancreatic cancer_Homo sapiens_hsa052120.62725220
80Renin-angiotensin system_Homo sapiens_hsa046140.62321928
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61456337
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.60067384
83T cell receptor signaling pathway_Homo sapiens_hsa046600.59982514
84Glioma_Homo sapiens_hsa052140.59292911
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59273751
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58919497
87Small cell lung cancer_Homo sapiens_hsa052220.57069500
88Type I diabetes mellitus_Homo sapiens_hsa049400.55814300
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55217130
90AMPK signaling pathway_Homo sapiens_hsa041520.54747745
91HIF-1 signaling pathway_Homo sapiens_hsa040660.54338945
92Starch and sucrose metabolism_Homo sapiens_hsa005000.54152356
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53315702
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52671993
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51835266
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51811527
97Proteoglycans in cancer_Homo sapiens_hsa052050.51671584
98Thyroid cancer_Homo sapiens_hsa052160.51054771
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50296039
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48790755
101Vibrio cholerae infection_Homo sapiens_hsa051100.48758642
102Collecting duct acid secretion_Homo sapiens_hsa049660.46227093
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.46150974
104Galactose metabolism_Homo sapiens_hsa000520.45726623
105Mineral absorption_Homo sapiens_hsa049780.44845804
106Prolactin signaling pathway_Homo sapiens_hsa049170.43739014
107Insulin resistance_Homo sapiens_hsa049310.39898615
108Epstein-Barr virus infection_Homo sapiens_hsa051690.39890134
109Focal adhesion_Homo sapiens_hsa045100.37626835
110VEGF signaling pathway_Homo sapiens_hsa043700.35087574
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34509289
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.34232853
113Viral carcinogenesis_Homo sapiens_hsa052030.30959661
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30323907
115Endocytosis_Homo sapiens_hsa041440.29993889
116Dilated cardiomyopathy_Homo sapiens_hsa054140.28690893
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26621757
118FoxO signaling pathway_Homo sapiens_hsa040680.24051629
119HTLV-I infection_Homo sapiens_hsa051660.23453901
120ECM-receptor interaction_Homo sapiens_hsa045120.22918148
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21633494
122ABC transporters_Homo sapiens_hsa020100.21569255
123Prion diseases_Homo sapiens_hsa050200.19240519

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