DNASE1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)9.72937204
2DNA strand renaturation (GO:0000733)9.70146210
3desmosome organization (GO:0002934)9.46690950
4negative regulation of cell aging (GO:0090344)9.26460242
5adenosine receptor signaling pathway (GO:0001973)9.07200618
6meiotic chromosome segregation (GO:0045132)8.65140820
7rRNA methylation (GO:0031167)8.12249413
8adenine nucleotide transport (GO:0051503)7.75675913
9peptide cross-linking (GO:0018149)7.67966625
10regulation of skeletal muscle contraction (GO:0014819)7.66093939
11purinergic nucleotide receptor signaling pathway (GO:0035590)7.65574738
12purine ribonucleotide transport (GO:0015868)7.39486117
13intermediate filament organization (GO:0045109)7.29808129
14multicellular organismal water homeostasis (GO:0050891)7.21698877
15positive regulation of protein kinase C signaling (GO:0090037)7.20104958
16rRNA modification (GO:0000154)6.97996913
17lens fiber cell differentiation (GO:0070306)6.82668464
18regulation of synapse structural plasticity (GO:0051823)6.65447301
19keratinocyte differentiation (GO:0030216)6.48618601
20nucleoside transmembrane transport (GO:1901642)6.25859624
21response to ATP (GO:0033198)6.21890201
22nucleotide transmembrane transport (GO:1901679)6.14665682
23sensory perception of taste (GO:0050909)6.07865826
24purine nucleotide transport (GO:0015865)6.05766604
25virion attachment to host cell (GO:0019062)5.78526140
26adhesion of symbiont to host cell (GO:0044650)5.78526140
27urinary tract smooth muscle contraction (GO:0014848)5.77698057
28water homeostasis (GO:0030104)5.77183750
29skin morphogenesis (GO:0043589)5.72029250
30purinergic receptor signaling pathway (GO:0035587)5.66759208
31protein carboxylation (GO:0018214)5.55599649
32peptidyl-glutamic acid carboxylation (GO:0017187)5.55599649
33melanin biosynthetic process (GO:0042438)5.54086625
34UV protection (GO:0009650)5.46625304
35peristalsis (GO:0030432)5.27045039
36* epidermis development (GO:0008544)5.16354240
37regulation of protein kinase A signaling (GO:0010738)5.15681957
38long-chain fatty acid biosynthetic process (GO:0042759)5.13564001
39behavioral response to nicotine (GO:0035095)5.03913488
40epidermal cell differentiation (GO:0009913)5.02146596
41melanin metabolic process (GO:0006582)5.01303072
42sex determination (GO:0007530)5.01252651
43G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.87273658
44positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.86178804
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.85399590
46adhesion of symbiont to host (GO:0044406)4.78972907
47nucleotide-sugar biosynthetic process (GO:0009226)4.78475031
48DNA replication checkpoint (GO:0000076)4.65595685
49intermediate filament cytoskeleton organization (GO:0045104)4.59918824
50hemidesmosome assembly (GO:0031581)4.58120243
51nucleoside transport (GO:0015858)4.55156016
52gonadal mesoderm development (GO:0007506)4.52992053
53secondary metabolite biosynthetic process (GO:0044550)4.52075491
54intermediate filament-based process (GO:0045103)4.48586915
55hormone catabolic process (GO:0042447)4.45521624
56histone phosphorylation (GO:0016572)4.41143086
57regulation of cell aging (GO:0090342)4.35509965
583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.27042867
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.27042867
60bundle of His cell to Purkinje myocyte communication (GO:0086069)4.25012107
61sialylation (GO:0097503)4.21118090
62neuromuscular synaptic transmission (GO:0007274)4.19803756
63regulation of cytokine production involved in inflammatory response (GO:1900015)4.16459108
64regulation of nuclear cell cycle DNA replication (GO:0033262)4.14500487
65regulation of transforming growth factor beta1 production (GO:0032908)4.08717391
66mitotic cell cycle arrest (GO:0071850)4.07780338
67citrulline biosynthetic process (GO:0019240)3.96184208
68ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.91326062
69nucleoside bisphosphate biosynthetic process (GO:0033866)3.91326062
70purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.91326062
71linoleic acid metabolic process (GO:0043651)3.89553872
72detection of light stimulus involved in visual perception (GO:0050908)3.89202981
73detection of light stimulus involved in sensory perception (GO:0050962)3.89202981
74grooming behavior (GO:0007625)3.88329386
75tRNA modification (GO:0006400)3.87873532
76hair follicle morphogenesis (GO:0031069)3.87040497
77positive regulation of catecholamine secretion (GO:0033605)3.77428962
78regulation of ruffle assembly (GO:1900027)3.71118043
79sphingomyelin metabolic process (GO:0006684)3.69943109
80positive regulation of heat generation (GO:0031652)3.67131766
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.66640013
82activation of adenylate cyclase activity (GO:0007190)3.49768638
83mannose metabolic process (GO:0006013)3.42053489
84nucleotide transport (GO:0006862)3.38040866
85sulfur amino acid catabolic process (GO:0000098)3.36887030
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.36488761
87ectoderm development (GO:0007398)3.36117032
88phosphatidylglycerol biosynthetic process (GO:0006655)3.35464302
89fatty acid elongation (GO:0030497)3.34521038
90estrogen biosynthetic process (GO:0006703)3.31931093
91regulation of hydrogen peroxide metabolic process (GO:0010310)3.31120357
92regulation of phospholipid biosynthetic process (GO:0071071)3.28252451
93folic acid metabolic process (GO:0046655)3.27547778
94cellular anion homeostasis (GO:0030002)3.19906349
95positive regulation of glomerulus development (GO:0090193)3.17514683
96substrate-independent telencephalic tangential migration (GO:0021826)3.12635084
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.12635084
98regulation of clathrin-mediated endocytosis (GO:2000369)3.12036973
99L-serine transport (GO:0015825)3.11388011
100cell wall macromolecule catabolic process (GO:0016998)3.11237048
101cell wall macromolecule metabolic process (GO:0044036)3.11237048
102phosphate ion homeostasis (GO:0055062)3.10641667
103trivalent inorganic anion homeostasis (GO:0072506)3.10641667
104antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09126607
105antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09126607
106urogenital system development (GO:0001655)3.07050472
107protein import into peroxisome matrix (GO:0016558)3.05006130
108positive regulation of adenylate cyclase activity (GO:0045762)3.04182455
109behavioral response to pain (GO:0048266)3.03410349
110iron coordination entity transport (GO:1901678)3.02907913
111dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.98925153
112regulation of protein kinase C signaling (GO:0090036)2.97246726
113keratan sulfate biosynthetic process (GO:0018146)2.97139480
114reciprocal DNA recombination (GO:0035825)2.96453408
115reciprocal meiotic recombination (GO:0007131)2.96453408
116cell migration in hindbrain (GO:0021535)2.95694939
117muscle fiber development (GO:0048747)2.93993783
118cornea development in camera-type eye (GO:0061303)2.92106382
119protein insertion into membrane (GO:0051205)2.91327205
120keratinocyte proliferation (GO:0043616)2.89706308
121negative regulation of interleukin-8 production (GO:0032717)2.85225253
122negative regulation of tumor necrosis factor production (GO:0032720)2.82033371
123phosphate ion transmembrane transport (GO:0035435)2.80671249
124interferon-gamma production (GO:0032609)2.80364126
125endocytic recycling (GO:0032456)2.79807070
126granulocyte differentiation (GO:0030851)2.78877239
127cardiolipin metabolic process (GO:0032048)2.77276215
128sphingoid metabolic process (GO:0046519)2.77260551
129antigen processing and presentation of endogenous antigen (GO:0019883)2.76772153
130heme transport (GO:0015886)2.76600773
131serine transport (GO:0032329)2.75821052
132positive regulation of cyclase activity (GO:0031281)2.75343219
133phosphatidylinositol acyl-chain remodeling (GO:0036149)2.72958752
134detection of bacterium (GO:0016045)2.72283159
135positive regulation of transforming growth factor beta production (GO:0071636)2.68801290
136citrulline metabolic process (GO:0000052)2.67324898
137peptidyl-arginine modification (GO:0018195)2.64901969
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.61492650
139lipoxygenase pathway (GO:0019372)2.60885248
140ovulation cycle (GO:0042698)2.60199160
141negative regulation of Ras GTPase activity (GO:0034261)2.58731706
142* hair cycle process (GO:0022405)2.57485267
143* molting cycle process (GO:0022404)2.57485267
144presynaptic membrane organization (GO:0097090)2.55152187
145G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.54887913
146positive regulation of cholesterol efflux (GO:0010875)2.52447483
147chemical homeostasis within a tissue (GO:0048875)2.51538374
148positive regulation of cholesterol transport (GO:0032376)2.51168696
149positive regulation of sterol transport (GO:0032373)2.51168696
150phosphatidylserine acyl-chain remodeling (GO:0036150)2.46872448
151sodium ion export (GO:0071436)2.40529935
152regulation of heart rate by cardiac conduction (GO:0086091)2.37923296
153positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.37296094
154* epithelium development (GO:0060429)2.37199275
155phosphatidylserine metabolic process (GO:0006658)2.36709918
156cerebellar granule cell differentiation (GO:0021707)2.36284904
157detection of other organism (GO:0098543)2.31498476
158positive regulation of monocyte chemotaxis (GO:0090026)2.30914874
159pyrimidine ribonucleoside catabolic process (GO:0046133)2.30721091
160surfactant homeostasis (GO:0043129)2.30709492
161synaptic vesicle docking involved in exocytosis (GO:0016081)2.29240369
162peptide catabolic process (GO:0043171)2.29007659
163regulation of cell proliferation involved in kidney development (GO:1901722)2.27479850
164cell communication involved in cardiac conduction (GO:0086065)2.27197258
165long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.25292409
166beta-amyloid metabolic process (GO:0050435)2.24126379
167phospholipid efflux (GO:0033700)2.23260830
168phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.22678047
169response to histamine (GO:0034776)2.21455228
170neurotransmitter-gated ion channel clustering (GO:0072578)2.20389237
171ventricular cardiac muscle cell action potential (GO:0086005)2.19022057
172phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.18922874
173diol metabolic process (GO:0034311)2.18558002
174keratinocyte development (GO:0003334)2.17150236
175sphingosine metabolic process (GO:0006670)2.15165883
176transepithelial transport (GO:0070633)2.14866790
177myotube differentiation (GO:0014902)2.13629191
178positive T cell selection (GO:0043368)2.13091085
179skin development (GO:0043588)2.12635127
180regulation of skeletal muscle cell differentiation (GO:2001014)2.11778452
181cardiac conduction (GO:0061337)2.09406233
182very long-chain fatty acid metabolic process (GO:0000038)2.08481844
183presynaptic membrane assembly (GO:0097105)2.08429177
184regulation of neuron projection regeneration (GO:0070570)2.07887949
185regulation of axon regeneration (GO:0048679)2.07887949
186negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.06659989
187positive thymic T cell selection (GO:0045059)2.06260408
188glucosamine-containing compound catabolic process (GO:1901072)2.05891906
189cellular potassium ion homeostasis (GO:0030007)2.03357037
190molting cycle (GO:0042303)19.4373921
191hair cycle (GO:0042633)19.4373921
192keratinization (GO:0031424)14.0836499
193establishment of skin barrier (GO:0061436)12.2502105
194cellular response to ATP (GO:0071318)11.1739703
195regulation of water loss via skin (GO:0033561)10.7402802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.94533308
2VDR_21846776_ChIP-Seq_THP-1_Human4.50259705
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.37873343
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05657349
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.83602638
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55963645
7MAF_26560356_Chip-Seq_TH2_Human2.53305987
8* XRN2_22483619_ChIP-Seq_HELA_Human2.52471491
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43835116
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39291547
11DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26079074
12* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.21990648
13ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.17230342
14RARB_24833708_ChIP-Seq_LIVER_Mouse2.02847514
15* VDR_24763502_ChIP-Seq_THP-1_Human2.02781120
16CTCF_27219007_Chip-Seq_ERYTHROID_Human2.01450559
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96926382
18* TET1_21451524_ChIP-Seq_MESCs_Mouse1.96870130
19* MAF_26560356_Chip-Seq_TH1_Human1.89475582
20DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86978147
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.85830080
22RARA_24833708_ChIP-Seq_LIVER_Mouse1.85800144
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85081078
24* FOXP1_21924763_ChIP-Seq_HESCs_Human1.78273148
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78235996
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77142572
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.75269030
28MYC_22102868_ChIP-Seq_BL_Human1.74497121
29SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74330225
30LXR_22292898_ChIP-Seq_THP-1_Human1.73372495
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.71372259
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.70485909
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.70263818
34CTCF_21964334_Chip-Seq_Bcells_Human1.69291941
35AR_21572438_ChIP-Seq_LNCaP_Human1.68786736
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67991062
37* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.66509033
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65850969
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65500688
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64807718
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64640826
42KDM2B_26808549_Chip-Seq_DND41_Human1.63935035
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.63102174
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.62033402
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61263225
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61232621
47* CTCF_27219007_Chip-Seq_Bcells_Human1.56832250
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56804912
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.56272761
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54563014
51RXR_22108803_ChIP-Seq_LS180_Human1.54117197
52CREB1_26743006_Chip-Seq_LNCaP_Human1.49747981
53CTCF_21964334_ChIP-Seq_BJAB-B_Human1.49034738
54UTX_26944678_Chip-Seq_JUKART_Human1.47313642
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47006097
56TP63_22573176_ChIP-Seq_HFKS_Human1.46804205
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45336947
58SA1_27219007_Chip-Seq_Bcells_Human1.45072567
59* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44166007
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.43741683
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43375874
62CTCF_20526341_ChIP-Seq_ESCs_Human1.43150944
63TAF2_19829295_ChIP-Seq_ESCs_Human1.42505707
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.40965600
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40906400
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40822797
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.40629385
68E2F1_20622854_ChIP-Seq_HELA_Human1.40423804
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39836852
70DROSHA_22980978_ChIP-Seq_HELA_Human1.39682034
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39439452
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39439452
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.37460818
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36735269
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36600684
76TCF7_22412390_ChIP-Seq_EML_Mouse1.35760541
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35715076
78* ERA_21632823_ChIP-Seq_H3396_Human1.34390468
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34317630
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34279741
81TP53_22127205_ChIP-Seq_IMR90_Human1.33471336
82DCP1A_22483619_ChIP-Seq_HELA_Human1.32959029
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.32776920
84* ETS1_21867929_ChIP-Seq_TH2_Mouse1.32037108
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31211312
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30946922
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.30229311
88TP63_23658742_ChIP-Seq_EP156T_Human1.29333420
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28322640
90AHR_22903824_ChIP-Seq_MCF-7_Human1.28022257
91* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27787463
92JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.26433420
93* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25747159
94CEBPB_22108803_ChIP-Seq_LS180_Human1.25464400
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24986547
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24829260
97NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.24306779
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23426321
99KDM2B_26808549_Chip-Seq_K562_Human1.22055727
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21996528
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21996528
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.21926090
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21854454
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20411112
105P300_27268052_Chip-Seq_Bcells_Human1.19439651
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19034398
107TP53_18474530_ChIP-ChIP_U2OS_Human1.18784110
108NCOR1_26117541_ChIP-Seq_K562_Human1.18685208
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18415455
110FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18097624
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17308573
112CTCF_26484167_Chip-Seq_Bcells_Mouse1.17146587
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17077397
114RACK7_27058665_Chip-Seq_MCF-7_Human1.16908304
115ATF3_27146783_Chip-Seq_COLON_Human1.15079569
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.15058847
117SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12535715
118MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.11805801
119GATA6_21074721_ChIP-Seq_CACO-2_Human1.11335505
120CSB_26484114_Chip-Seq_FIBROBLAST_Human1.11143211
121P68_20966046_ChIP-Seq_HELA_Human1.10684393
122P53_21459846_ChIP-Seq_SAOS-2_Human1.10026120
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09632713
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08854634
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.07518608
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.07413118
127* BCL6_27268052_Chip-Seq_Bcells_Human1.06435083
128SMC4_20622854_ChIP-Seq_HELA_Human1.06395764
129GABP_19822575_ChIP-Seq_HepG2_Human1.06242092
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06193923
131KLF5_25053715_ChIP-Seq_YYC3_Human1.06179448
132VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06149329
133BCOR_27268052_Chip-Seq_Bcells_Human1.05708597
134ERG_20517297_ChIP-Seq_VCAP_Human1.05524450
135OCT4_19829295_ChIP-Seq_ESCs_Human1.05518695
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05409008
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05144416
138CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05019808
139EED_16625203_ChIP-ChIP_MESCs_Mouse1.04685152
140CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01795875
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01532032
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99792910
143* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99563818
144STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98591853
145* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98052832
146* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97983893
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97849374
148SMAD4_21741376_ChIP-Seq_ESCs_Human0.95376169
149RARB_27405468_Chip-Seq_BRAIN_Mouse0.94978056
150* ERG_21242973_ChIP-ChIP_JURKAT_Human0.94245299
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.93809051
152BCAT_22108803_ChIP-Seq_LS180_Human0.93011707
153YY1_22570637_ChIP-Seq_MALME-3M_Human0.92904393
154CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90276840
155ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90258228
156PHF8_20622854_ChIP-Seq_HELA_Human0.90093851
157KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89584584
158* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89063075
159* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87941767
160AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86405521
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.84826307
162RING1B_27294783_Chip-Seq_ESCs_Mouse0.84380080
163SOX2_20726797_ChIP-Seq_SW620_Human0.84273241
164EGR1_19032775_ChIP-ChIP_M12_Human0.82882817
165ELF1_20517297_ChIP-Seq_JURKAT_Human0.82828816
166KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81751558
167TRIM28_21343339_ChIP-Seq_HEK293_Human0.81658970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.77843960
2MP0005171_absent_coat_pigmentation7.50763398
3MP0003136_yellow_coat_color6.96391782
4MP0001986_abnormal_taste_sensitivity6.95249183
5MP0005174_abnormal_tail_pigmentation6.68502109
6MP0010234_abnormal_vibrissa_follicle6.55721143
7MP0000579_abnormal_nail_morphology5.73161879
8MP0005275_abnormal_skin_tensile5.45300918
9MP0005501_abnormal_skin_physiology4.73642462
10MP0002098_abnormal_vibrissa_morphology4.04488568
11MP0000647_abnormal_sebaceous_gland3.84125594
12MP0010678_abnormal_skin_adnexa3.31233752
13MP0005451_abnormal_body_composition3.15379489
14MP0004947_skin_inflammation2.93255482
15MP0000383_abnormal_hair_follicle2.92810421
16MP0001216_abnormal_epidermal_layer2.92507342
17MP0010771_integument_phenotype2.86256066
18MP0000377_abnormal_hair_follicle2.80205157
19MP0000015_abnormal_ear_pigmentation2.74929987
20MP0003941_abnormal_skin_development2.68404340
21MP0002254_reproductive_system_inflammat2.59125555
22MP0002060_abnormal_skin_morphology2.53145690
23MP0005083_abnormal_biliary_tract2.45091882
24MP0000427_abnormal_hair_cycle2.37453019
25MP0002638_abnormal_pupillary_reflex2.31535510
26MP0004381_abnormal_hair_follicle2.31405993
27MP0001756_abnormal_urination2.16058372
28MP0003705_abnormal_hypodermis_morpholog1.98051450
29MP0000467_abnormal_esophagus_morphology1.82317918
30MP0004185_abnormal_adipocyte_glucose1.74817302
31MP0003453_abnormal_keratinocyte_physiol1.73965376
32MP0000367_abnormal_coat/_hair1.73310524
33MP0008875_abnormal_xenobiotic_pharmacok1.67154220
34MP0003191_abnormal_cellular_cholesterol1.65568096
35MP0009931_abnormal_skin_appearance1.62492776
36MP0009780_abnormal_chondrocyte_physiolo1.61003679
37MP0003111_abnormal_nucleus_morphology1.55844358
38MP0000750_abnormal_muscle_regeneration1.44446947
39MP0002735_abnormal_chemical_nociception1.41225322
40MP0005409_darkened_coat_color1.38362136
41MP0000013_abnormal_adipose_tissue1.35366127
42MP0001661_extended_life_span1.28329253
43MP0002234_abnormal_pharynx_morphology1.25130183
44MP0004043_abnormal_pH_regulation1.24828676
45MP0001243_abnormal_dermal_layer1.24507027
46MP0003329_amyloid_beta_deposits1.19515018
47MP0002009_preneoplasia1.18901523
48MP0001191_abnormal_skin_condition1.18283335
49MP0005365_abnormal_bile_salt1.08828024
50MP0005332_abnormal_amino_acid1.08512640
51MP0005076_abnormal_cell_differentiation1.06676561
52MP0003183_abnormal_peptide_metabolism1.03337954
53MP0005584_abnormal_enzyme/coenzyme_acti1.02777602
54MP0000762_abnormal_tongue_morphology1.01643535
55MP0000003_abnormal_adipose_tissue1.00034225
56MP0004885_abnormal_endolymph0.99983528
57MP0005084_abnormal_gallbladder_morpholo0.95929534
58MP0005330_cardiomyopathy0.95615049
59MP0003693_abnormal_embryo_hatching0.95525042
60MP0002877_abnormal_melanocyte_morpholog0.93389365
61MP0002166_altered_tumor_susceptibility0.91672858
62MP0005551_abnormal_eye_electrophysiolog0.91610875
63MP0008961_abnormal_basal_metabolism0.88194667
64MP0005310_abnormal_salivary_gland0.87304258
65MP0003806_abnormal_nucleotide_metabolis0.86561428
66MP0001958_emphysema0.86074639
67MP0008569_lethality_at_weaning0.85074312
68MP0004019_abnormal_vitamin_homeostasis0.83462463
69MP0010386_abnormal_urinary_bladder0.80569061
70MP0004957_abnormal_blastocyst_morpholog0.80561049
71MP0002160_abnormal_reproductive_system0.78477053
72MP0001905_abnormal_dopamine_level0.78185445
73MP0001346_abnormal_lacrimal_gland0.77633837
74MP0000465_gastrointestinal_hemorrhage0.76708198
75MP0005423_abnormal_somatic_nervous0.76302093
76MP0001188_hyperpigmentation0.74595769
77MP0000751_myopathy0.73178251
78MP0005058_abnormal_lysosome_morphology0.72744591
79MP0000604_amyloidosis0.72480874
80MP0003448_altered_tumor_morphology0.70951634
81MP0002075_abnormal_coat/hair_pigmentati0.69176101
82MP0000566_synostosis0.68577795
83MP0001970_abnormal_pain_threshold0.67986108
84MP0004859_abnormal_synaptic_plasticity0.67873367
85MP0004742_abnormal_vestibular_system0.66661840
86MP0003566_abnormal_cell_adhesion0.66289151
87MP0005377_hearing/vestibular/ear_phenot0.65169275
88MP0003878_abnormal_ear_physiology0.65169275
89MP0001984_abnormal_olfaction0.65160902
90MP0009046_muscle_twitch0.65106816
91MP0009384_cardiac_valve_regurgitation0.64348008
92MP0001873_stomach_inflammation0.61842930
93MP0001851_eye_inflammation0.61418395
94MP0003137_abnormal_impulse_conducting0.61031241
95MP0003300_gastrointestinal_ulcer0.60819933
96MP0000358_abnormal_cell_content/0.59962331
97MP0005410_abnormal_fertilization0.59490556
98MP0004264_abnormal_extraembryonic_tissu0.59187499
99MP0001502_abnormal_circadian_rhythm0.59033014
100MP0002095_abnormal_skin_pigmentation0.58794526
101MP0001784_abnormal_fluid_regulation0.58542483
102MP0005666_abnormal_adipose_tissue0.56221014
103MP0003880_abnormal_central_pattern0.55953140
104MP0001968_abnormal_touch/_nociception0.55384430
105MP0000470_abnormal_stomach_morphology0.53922237
106MP0002019_abnormal_tumor_incidence0.53742108
107MP0010094_abnormal_chromosome_stability0.52384188
108MP0003635_abnormal_synaptic_transmissio0.52244687
109MP0002736_abnormal_nociception_after0.50687919
110MP0002006_tumorigenesis0.50143494
111MP0003077_abnormal_cell_cycle0.49766157
112MP0006072_abnormal_retinal_apoptosis0.49640057
113MP0008004_abnormal_stomach_pH0.48346861
114MP0001340_abnormal_eyelid_morphology0.47943669
115MP0009643_abnormal_urine_homeostasis0.47214950
116MP0003091_abnormal_cell_migration0.46650059
117MP0004130_abnormal_muscle_cell0.46225077
118MP0002090_abnormal_vision0.46217759
119MP0002909_abnormal_adrenal_gland0.44721072
120MP0005375_adipose_tissue_phenotype0.44229362
121MP0001186_pigmentation_phenotype0.43606553
122MP0005220_abnormal_exocrine_pancreas0.43517715
123MP0002933_joint_inflammation0.42989122
124MP0003763_abnormal_thymus_physiology0.41311748
125MP0002733_abnormal_thermal_nociception0.41259573
126MP0001348_abnormal_lacrimal_gland0.41185179
127MP0002136_abnormal_kidney_physiology0.40547966
128MP0001177_atelectasis0.38777330
129MP0002876_abnormal_thyroid_physiology0.38492683
130MP0009278_abnormal_bone_marrow0.38488933
131MP0002970_abnormal_white_adipose0.37847899
132MP0000371_diluted_coat_color0.37185934
133MP0000778_abnormal_nervous_system0.37024925
134MP0004270_analgesia0.37022626
135MP0001299_abnormal_eye_distance/0.36658128
136MP0003303_peritoneal_inflammation0.35740757
137MP0002063_abnormal_learning/memory/cond0.34996222
138MP0003315_abnormal_perineum_morphology0.34254767
139MP0001324_abnormal_eye_pigmentation0.34169951
140MP0005647_abnormal_sex_gland0.34164261
141MP0000538_abnormal_urinary_bladder0.33748292
142MP0002184_abnormal_innervation0.33661579
143MP0002971_abnormal_brown_adipose0.33513598
144MP0010329_abnormal_lipoprotein_level0.32690609
145MP0002928_abnormal_bile_duct0.32435547
146MP0006054_spinal_hemorrhage0.31736244
147MP0008874_decreased_physiological_sensi0.30757485
148MP0001664_abnormal_digestion0.30488120
149MP0002064_seizures0.29784476
150MP0001919_abnormal_reproductive_system0.29387190
151MP0001765_abnormal_ion_homeostasis0.29374725
152MP0000678_abnormal_parathyroid_gland0.29219381
153MP0002177_abnormal_outer_ear0.28347234
154MP0004215_abnormal_myocardial_fiber0.27994750
155MP0000747_muscle_weakness0.27911984
156MP0004197_abnormal_fetal_growth/weight/0.27798090
157MP0001440_abnormal_grooming_behavior0.27778849
158MP0002572_abnormal_emotion/affect_behav0.27502793
159MP0002210_abnormal_sex_determination0.27085063
160MP0003632_abnormal_nervous_system0.26937465
161MP0006276_abnormal_autonomic_nervous0.25037438
162MP0002118_abnormal_lipid_homeostasis0.23434259
163MP0005257_abnormal_intraocular_pressure0.22959114
164MP0000026_abnormal_inner_ear0.22549137
165MP0005535_abnormal_body_temperature0.21851440

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)9.97917427
2Abnormality of nail color (HP:0100643)8.76510883
3Increased IgE level (HP:0003212)7.92372064
4Woolly hair (HP:0002224)7.79976005
5Rib fusion (HP:0000902)6.91185604
6Brittle hair (HP:0002299)6.62115347
7Slow-growing hair (HP:0002217)6.48081030
8Abnormality of hair growth rate (HP:0011363)6.48081030
9Testicular atrophy (HP:0000029)6.27883405
10Pili torti (HP:0003777)6.27142087
11Congenital ichthyosiform erythroderma (HP:0007431)6.26848442
12Rectovaginal fistula (HP:0000143)5.92346771
13Rectal fistula (HP:0100590)5.92346771
14Onycholysis (HP:0001806)5.88028494
15Intestinal fistula (HP:0100819)5.58341767
16Poikiloderma (HP:0001029)5.56864659
17Vaginal fistula (HP:0004320)5.49147324
18Palmoplantar hyperkeratosis (HP:0000972)5.39947771
19Annular pancreas (HP:0001734)5.34851577
20Thin bony cortex (HP:0002753)5.27867503
21Facial hemangioma (HP:0000329)5.21578207
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.19779514
23Ulnar bowing (HP:0003031)5.16581104
24Palmar hyperkeratosis (HP:0010765)5.03593854
25Attenuation of retinal blood vessels (HP:0007843)4.95566944
26Plantar hyperkeratosis (HP:0007556)4.95229335
27Congenital stationary night blindness (HP:0007642)4.93148959
28Nail dystrophy (HP:0008404)4.88732383
29Turricephaly (HP:0000262)4.88576175
30Popliteal pterygium (HP:0009756)4.71207630
31Coronal craniosynostosis (HP:0004440)4.62187452
32Right ventricular cardiomyopathy (HP:0011663)4.56267335
33Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.47933532
34Fragile nails (HP:0001808)4.47125969
35Akinesia (HP:0002304)4.43278472
36Dyschromatopsia (HP:0007641)4.31799799
37Abnormality of the intrinsic pathway (HP:0010989)4.15745314
38Erythroderma (HP:0001019)4.14832845
39Thick nail (HP:0001805)4.05233531
40Aplasia of the musculature (HP:0100854)3.97296631
41Squamous cell carcinoma (HP:0002860)3.88422307
42Fetal akinesia sequence (HP:0001989)3.88381235
43Facial diplegia (HP:0001349)3.82311382
44Anteriorly placed anus (HP:0001545)3.82020141
45Conjunctival hamartoma (HP:0100780)3.81710617
46Chorioretinal atrophy (HP:0000533)3.78249206
47Erythema (HP:0010783)3.77552595
48Short chin (HP:0000331)3.75627958
49Bony spicule pigmentary retinopathy (HP:0007737)3.73062719
50Delayed epiphyseal ossification (HP:0002663)3.67238266
51Abnormal hair laboratory examination (HP:0003328)3.66647988
52Patellar aplasia (HP:0006443)3.55224873
53Corneal erosion (HP:0200020)3.46877990
54Alopecia of scalp (HP:0002293)3.38013665
55Gangrene (HP:0100758)3.37276736
56Amniotic constriction ring (HP:0009775)3.37197877
57Abnormality of placental membranes (HP:0011409)3.37197877
58Curly hair (HP:0002212)3.31167646
59Abnormality of the costochondral junction (HP:0000919)3.28791044
60Ectropion (HP:0000656)3.27953382
61Aplasia/Hypoplasia of the patella (HP:0006498)3.27185944
62Fine hair (HP:0002213)3.20277865
63Birth length less than 3rd percentile (HP:0003561)3.18808637
64Milia (HP:0001056)3.13873156
65Capillary hemangiomas (HP:0005306)3.13037315
66Hypohidrosis (HP:0000966)3.11592051
67Male infertility (HP:0003251)3.11278500
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07070667
69Hyporeflexia of lower limbs (HP:0002600)3.06276261
70Prolonged partial thromboplastin time (HP:0003645)3.05272194
71Enlarged epiphyses (HP:0010580)3.04768526
72Oral leukoplakia (HP:0002745)2.98251613
73Follicular hyperkeratosis (HP:0007502)2.98161701
74Joint hemorrhage (HP:0005261)2.97864525
75Parakeratosis (HP:0001036)2.96575466
76Hypoalbuminemia (HP:0003073)2.95866137
77Abnormal albumin level (HP:0012116)2.95866137
78Joint stiffness (HP:0001387)2.91854414
79Palmoplantar keratoderma (HP:0000982)2.90923361
80Hamartoma of the eye (HP:0010568)2.88940415
81Hemorrhage of the eye (HP:0011885)2.87183774
82Absent thumb (HP:0009777)2.85852238
83Premature graying of hair (HP:0002216)2.85217968
84Atrioventricular block (HP:0001678)2.82281391
85Choanal stenosis (HP:0000452)2.80861619
86Lip pit (HP:0100267)2.77839661
87Bowing of the arm (HP:0006488)2.75669653
88Bowed forearm bones (HP:0003956)2.75669653
89Widely patent fontanelles and sutures (HP:0004492)2.75257264
90Aplasia involving bones of the upper limbs (HP:0009823)2.74831704
91Aplasia of the phalanges of the hand (HP:0009802)2.74831704
92Aplasia involving bones of the extremities (HP:0009825)2.74831704
93Abnormal blistering of the skin (HP:0008066)2.70857918
94Pruritus (HP:0000989)2.69131557
95Hypophosphatemic rickets (HP:0004912)2.67849078
96Myotonia (HP:0002486)2.65775108
97Sparse eyelashes (HP:0000653)2.59656745
98Mesangial abnormality (HP:0001966)2.58454894
99Flat occiput (HP:0005469)2.58407336
100Narrow nasal bridge (HP:0000446)2.57693858
101Increased number of teeth (HP:0011069)2.55108987
102Short humerus (HP:0005792)2.51179822
103Basal cell carcinoma (HP:0002671)2.41544997
104Reduced antithrombin III activity (HP:0001976)2.39870153
105Pendular nystagmus (HP:0012043)2.38342825
106Verrucae (HP:0200043)2.37349078
107Papilloma (HP:0012740)2.37349078
108Choroideremia (HP:0001139)2.34748846
109Breast hypoplasia (HP:0003187)2.33334513
110Polydipsia (HP:0001959)2.29689794
111Abnormal drinking behavior (HP:0030082)2.29689794
112Aplasia/hypoplasia of the humerus (HP:0006507)2.25520102
113Aplasia/Hypoplasia involving the musculature (HP:0001460)2.24818282
114Neonatal respiratory distress (HP:0002643)2.24647100
115Distal lower limb muscle weakness (HP:0009053)2.22716557
116Lack of skin elasticity (HP:0100679)2.22328872
117Advanced eruption of teeth (HP:0006288)2.21311737
118Thin ribs (HP:0000883)2.21137789
119Sensory axonal neuropathy (HP:0003390)2.20415525
120Intention tremor (HP:0002080)2.20172097
121Dry hair (HP:0011359)2.19614979
122Absent radius (HP:0003974)2.19584563
123Diminished movement (HP:0002374)2.18838777
124Myopathic facies (HP:0002058)2.18694241
125Decreased circulating renin level (HP:0003351)2.15992782
126Ventricular fibrillation (HP:0001663)2.15888479
127Decreased central vision (HP:0007663)2.15450320
128Hypergammaglobulinemia (HP:0010702)2.15407390
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14449566
130Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13731830
131Renal Fanconi syndrome (HP:0001994)2.12530110
132Malignant hyperthermia (HP:0002047)2.12150158
133Pterygium (HP:0001059)2.10038491
134Hypoplasia of the pons (HP:0012110)2.09709139
135Hyperinsulinemic hypoglycemia (HP:0000825)2.09345309
136Neonatal onset (HP:0003623)2.08818447
137Ventricular tachycardia (HP:0004756)2.08667057
138Absent forearm bone (HP:0003953)2.07377670
139Aplasia involving forearm bones (HP:0009822)2.07377670
140Abnormal epiphyseal ossification (HP:0010656)2.07079750
141Abnormality of the hepatic vasculature (HP:0006707)2.02610887
142Exercise-induced myalgia (HP:0003738)2.01345387
143Zonular cataract (HP:0010920)2.01266388
144Abnormality of secondary sexual hair (HP:0009888)2.01209774
145Abnormality of the axillary hair (HP:0100134)2.01209774
146Acanthosis nigricans (HP:0000956)2.00863509
147Type 2 muscle fiber atrophy (HP:0003554)1.99594480
148Eczematoid dermatitis (HP:0000976)1.97937883
149Short thumb (HP:0009778)1.96560658
150Cheilitis (HP:0100825)1.87912758
151Areflexia of lower limbs (HP:0002522)1.87303044
152Sudden death (HP:0001699)1.87230854
153Natal tooth (HP:0000695)1.87164009
154Muscle fiber atrophy (HP:0100295)1.87022414
155Abnormality of the pons (HP:0007361)1.86564147
156Hypoplasia of the radius (HP:0002984)1.85767700
157Cystic hygroma (HP:0000476)1.83020936
158Hyperthyroidism (HP:0000836)1.82928612
159Sparse scalp hair (HP:0002209)1.82783256
160Abnormality of homocysteine metabolism (HP:0010919)1.81511897
161Homocystinuria (HP:0002156)1.81511897
162Dehydration (HP:0001944)1.81233196
163Tubular atrophy (HP:0000092)1.81217622
164Congenital, generalized hypertrichosis (HP:0004540)1.77947744
165Ridged nail (HP:0001807)1.77770884
166Laryngomalacia (HP:0001601)1.77520721
167Abnormality of the neuromuscular junction (HP:0003398)1.76150872
168Fatigable weakness (HP:0003473)1.76150872
169Distal arthrogryposis (HP:0005684)1.73940436
170Neck muscle weakness (HP:0000467)1.73839389
171Hypoplastic nipples (HP:0002557)1.72993888
172Asthma (HP:0002099)1.66541559
173Concave nail (HP:0001598)1.66172566
174Amelogenesis imperfecta (HP:0000705)1.61466723
175Round ear (HP:0100830)1.59687695
176Abnormality of molar (HP:0011077)1.58033042
177Abnormality of molar morphology (HP:0011070)1.58033042
178Blepharitis (HP:0000498)1.56775574
179Type 1 muscle fiber predominance (HP:0003803)1.56059488
180Fibular aplasia (HP:0002990)1.54988272
181Abnormality of permanent molar morphology (HP:0011071)1.53964448
182Abnormality of the dental root (HP:0006486)1.53964448
183Taurodontia (HP:0000679)1.53964448
184Craniofacial hyperostosis (HP:0004493)1.53833288
185Abnormality of the frontal sinuses (HP:0002687)1.52303520
186Achilles tendon contracture (HP:0001771)1.48796794
187Abnormality of the gastric mucosa (HP:0004295)1.48769395
188Megalencephaly (HP:0001355)1.48293295
189Atrophic scars (HP:0001075)1.47915432
190Oligodontia (HP:0000677)1.47863335
191Torticollis (HP:0000473)1.47324554
192Sepsis (HP:0100806)1.39942176
193Neoplasm of the heart (HP:0100544)1.37508867
194Abnormality of the dental pulp (HP:0006479)1.37475009
195Ulnar deviation of finger (HP:0009465)1.35266917
196Ulnar deviation of the wrist (HP:0003049)1.34908920
197Distal lower limb amyotrophy (HP:0008944)1.34008048
198Abnormality of the Achilles tendon (HP:0005109)1.33004640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.28379262
2WNK45.52992061
3EPHA43.67572968
4BLK3.64612942
5CASK3.57643557
6TLK13.32147512
7ERN13.26488620
8TESK23.13942525
9MUSK3.09640955
10TRIB32.62013958
11STK162.59806518
12FER2.56484873
13TTN2.50060411
14TNIK2.44861035
15ZAK2.37728938
16SIK12.35539303
17NTRK32.26931716
18MST42.23846827
19ACVR1B2.08241110
20EPHA32.07120966
21PHKG22.05763536
22PHKG12.05763536
23TNK21.98581838
24TAOK11.90473416
25MAPKAPK31.88269862
26RIPK11.76452412
27BRD41.73302190
28AKT31.60336393
29WNK11.54080998
30MAP3K91.53204553
31MAP3K71.52774150
32IRAK21.47714603
33NME11.39383134
34SIK21.38563004
35EEF2K1.37748849
36PDK21.36211395
37CCNB11.33547145
38ZAP701.32994424
39FGFR11.30682235
40CDK191.28614737
41MAP3K21.26139001
42PDPK11.22085214
43SRPK11.21646023
44DMPK1.19748224
45MAP2K61.16345273
46PIK3CG1.16294322
47ADRBK21.15789981
48CDK41.13958457
49MARK21.13480549
50PRKD21.11464654
51CDK151.10641242
52BMPR1B1.05953254
53CDK181.03553516
54CDK11A1.02688295
55PTK61.01139651
56NEK20.99797700
57STK380.98866810
58MAP3K30.98651249
59FGFR30.97969210
60BMX0.97022806
61RPS6KA20.95317577
62MAP2K40.93905884
63MAPK110.93091055
64PRKCI0.92718118
65PRKD30.90759414
66DAPK20.90168435
67SGK30.90000187
68MAP2K30.84153109
69PAK60.78297346
70GRK60.77681155
71OXSR10.77415835
72PRKCH0.76804060
73JAK10.76094183
74SGK20.75541847
75FGFR20.75410512
76MAP4K10.74106503
77IKBKE0.73959124
78CDK140.73233074
79MST1R0.72332151
80TBK10.71848801
81MELK0.71146114
82STK110.70496444
83CDK60.70299517
84PKN10.69156566
85CSK0.68531433
86SYK0.67527962
87MAP3K60.67418518
88MAP3K40.67088740
89DYRK1A0.66849086
90LMTK20.66214276
91TAOK30.65771663
92RPS6KA60.65487101
93ITK0.65404501
94ARAF0.62922859
95TYK20.62848430
96CSNK1D0.61937365
97MARK30.61307085
98TGFBR10.60852166
99PIM20.60549407
100FGFR40.60366822
101MAPK120.60093019
102MAP2K70.59651425
103OBSCN0.58838339
104JAK20.58645395
105PKN20.57791998
106PAK30.56286165
107EPHA20.55499089
108NTRK20.55053544
109AURKA0.54780802
110MAP3K10.54520844
111CDC42BPA0.52740763
112MAPK80.51990944
113ICK0.51180902
114DYRK1B0.50190480
115RPS6KA50.50077634
116ROCK20.49494386
117FYN0.48702243
118EPHB20.48316794
119HCK0.48286901
120RAF10.47826792
121CDK50.47282489
122ATR0.44638267
123CAMK40.44135064
124MAP3K110.44049247
125RPS6KL10.43614889
126RPS6KC10.43614889
127CHEK20.42210558
128LATS10.41550190
129PRKCQ0.41117585
130SGK2230.40357853
131SGK4940.40357853
132EPHB10.40276352
133MTOR0.40097034
134SGK10.39744022
135ADRBK10.39215696
136MARK10.38956861
137SMG10.38770575
138MYLK0.38186669
139YES10.37014136
140ROCK10.36875706
141FGR0.36170622
142DYRK20.36130016
143TYRO30.35611846
144PRKD10.34711821
145HIPK20.34587088
146MAP3K100.33994437
147PLK10.33873743
148SRC0.33514528
149AKT20.33217562
150CAMKK10.32710226
151FES0.32114245
152STK390.31928704
153IKBKB0.31435351
154PRKAA10.29199629
155MAPKAPK50.26662130
156PAK10.26226976
157NEK60.24824825
158RPS6KB10.23891083
159MAPK130.23229246
160RPS6KA10.19087913
161CDK10.18012049
162PAK40.16561079
163DYRK30.16420099
164KSR20.14755195
165MET0.14700751

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041226.54612163
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.93299136
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.21268555
4Fructose and mannose metabolism_Homo sapiens_hsa000513.28767979
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.51872594
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.28382493
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17366808
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.10660650
9Long-term potentiation_Homo sapiens_hsa047202.10311665
10Linoleic acid metabolism_Homo sapiens_hsa005911.98716320
11Cyanoamino acid metabolism_Homo sapiens_hsa004601.92522556
12Fanconi anemia pathway_Homo sapiens_hsa034601.82877742
13ABC transporters_Homo sapiens_hsa020101.80864330
14Sphingolipid metabolism_Homo sapiens_hsa006001.77775384
15Renin secretion_Homo sapiens_hsa049241.73843024
16Olfactory transduction_Homo sapiens_hsa047401.72469872
17Nicotine addiction_Homo sapiens_hsa050331.65254470
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61462349
19Gastric acid secretion_Homo sapiens_hsa049711.56853486
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56178508
21Vitamin digestion and absorption_Homo sapiens_hsa049771.54420462
22Phototransduction_Homo sapiens_hsa047441.51444516
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50389550
24Arachidonic acid metabolism_Homo sapiens_hsa005901.50225585
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48739782
26Salivary secretion_Homo sapiens_hsa049701.47533156
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.47391437
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47367815
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47138372
30VEGF signaling pathway_Homo sapiens_hsa043701.46645145
31Synaptic vesicle cycle_Homo sapiens_hsa047211.39646829
32Circadian entrainment_Homo sapiens_hsa047131.39446782
33Hedgehog signaling pathway_Homo sapiens_hsa043401.38507312
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37849502
35Amphetamine addiction_Homo sapiens_hsa050311.36032961
36GnRH signaling pathway_Homo sapiens_hsa049121.35520688
37Fatty acid biosynthesis_Homo sapiens_hsa000611.34562244
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34019654
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33156858
40Circadian rhythm_Homo sapiens_hsa047101.29991281
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26633878
42Glioma_Homo sapiens_hsa052141.24830119
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23808997
44Glutamatergic synapse_Homo sapiens_hsa047241.23613815
45Long-term depression_Homo sapiens_hsa047301.22295572
46Ether lipid metabolism_Homo sapiens_hsa005651.14431991
47Morphine addiction_Homo sapiens_hsa050321.14168711
48Oxytocin signaling pathway_Homo sapiens_hsa049211.11841128
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10430889
50Calcium signaling pathway_Homo sapiens_hsa040201.08980954
51Non-small cell lung cancer_Homo sapiens_hsa052231.06267461
52Collecting duct acid secretion_Homo sapiens_hsa049661.03972296
53Acute myeloid leukemia_Homo sapiens_hsa052211.03456819
54Melanogenesis_Homo sapiens_hsa049161.02089535
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01341920
56Insulin secretion_Homo sapiens_hsa049111.01337442
57Estrogen signaling pathway_Homo sapiens_hsa049150.97551170
58Axon guidance_Homo sapiens_hsa043600.96363504
59Endometrial cancer_Homo sapiens_hsa052130.95907770
60Dopaminergic synapse_Homo sapiens_hsa047280.95675013
61ErbB signaling pathway_Homo sapiens_hsa040120.95612772
62Fat digestion and absorption_Homo sapiens_hsa049750.92928210
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92560251
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91742363
65Insulin resistance_Homo sapiens_hsa049310.91497939
66GABAergic synapse_Homo sapiens_hsa047270.90940120
67Glucagon signaling pathway_Homo sapiens_hsa049220.90906231
68Serotonergic synapse_Homo sapiens_hsa047260.86874012
69Bladder cancer_Homo sapiens_hsa052190.85941559
70Pancreatic secretion_Homo sapiens_hsa049720.85720066
71Glycerolipid metabolism_Homo sapiens_hsa005610.84975135
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.83218162
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82957683
74Primary immunodeficiency_Homo sapiens_hsa053400.82377818
75Inositol phosphate metabolism_Homo sapiens_hsa005620.81427534
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81190975
77Cocaine addiction_Homo sapiens_hsa050300.78838017
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77936093
79cAMP signaling pathway_Homo sapiens_hsa040240.77597539
80Insulin signaling pathway_Homo sapiens_hsa049100.77030786
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75921198
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75296624
83Taste transduction_Homo sapiens_hsa047420.73740188
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73080627
85Lysine degradation_Homo sapiens_hsa003100.72549390
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72023963
87Pyruvate metabolism_Homo sapiens_hsa006200.71857921
88Basal cell carcinoma_Homo sapiens_hsa052170.71797050
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.71462603
90T cell receptor signaling pathway_Homo sapiens_hsa046600.70469458
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70183747
92Cholinergic synapse_Homo sapiens_hsa047250.70126540
93Fatty acid elongation_Homo sapiens_hsa000620.69605354
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69437573
95RNA polymerase_Homo sapiens_hsa030200.69281699
96Hepatitis C_Homo sapiens_hsa051600.66228247
97Ovarian steroidogenesis_Homo sapiens_hsa049130.65842359
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65555346
99Hippo signaling pathway_Homo sapiens_hsa043900.65530504
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.62900088
101Other glycan degradation_Homo sapiens_hsa005110.61713985
102MAPK signaling pathway_Homo sapiens_hsa040100.61474464
103Proteoglycans in cancer_Homo sapiens_hsa052050.60182873
104Dorso-ventral axis formation_Homo sapiens_hsa043200.58292945
105Fatty acid degradation_Homo sapiens_hsa000710.56408124
106Homologous recombination_Homo sapiens_hsa034400.56103042
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55478766
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55160761
109mTOR signaling pathway_Homo sapiens_hsa041500.54883063
110Vibrio cholerae infection_Homo sapiens_hsa051100.54864034
111Choline metabolism in cancer_Homo sapiens_hsa052310.54770659
112Tight junction_Homo sapiens_hsa045300.54306133
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.53959907
114Phenylalanine metabolism_Homo sapiens_hsa003600.53492392
115Ras signaling pathway_Homo sapiens_hsa040140.53332167
116B cell receptor signaling pathway_Homo sapiens_hsa046620.52264808
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52157861
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.51641217
119Prostate cancer_Homo sapiens_hsa052150.51510845
120Lysosome_Homo sapiens_hsa041420.50598071
121Endocytosis_Homo sapiens_hsa041440.50317953
122Thyroid hormone synthesis_Homo sapiens_hsa049180.49013672
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48541495
124PPAR signaling pathway_Homo sapiens_hsa033200.48395820
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48058497
126Caffeine metabolism_Homo sapiens_hsa002320.47846653
127Platelet activation_Homo sapiens_hsa046110.47697216
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46978171
129Base excision repair_Homo sapiens_hsa034100.43966071
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43160607
131Alcoholism_Homo sapiens_hsa050340.40603962
132Arginine biosynthesis_Homo sapiens_hsa002200.38852198
133Gap junction_Homo sapiens_hsa045400.31291765
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29728614
135Notch signaling pathway_Homo sapiens_hsa043300.29564833
136Metabolic pathways_Homo sapiens_hsa011000.28184747
137Pyrimidine metabolism_Homo sapiens_hsa002400.26766723
138Histidine metabolism_Homo sapiens_hsa003400.24658815
139Steroid biosynthesis_Homo sapiens_hsa001000.23191028
140Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21976996
141Chemical carcinogenesis_Homo sapiens_hsa052040.20587204
142Cell cycle_Homo sapiens_hsa041100.19966163
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18934406
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.18845137
145Basal transcription factors_Homo sapiens_hsa030220.18309339
146Biosynthesis of amino acids_Homo sapiens_hsa012300.17938151
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.17242762
148Nitrogen metabolism_Homo sapiens_hsa009100.16576462
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15127852
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.13198784
151Tyrosine metabolism_Homo sapiens_hsa003500.11515666
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.09499851
153N-Glycan biosynthesis_Homo sapiens_hsa005100.08905165
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.08614634
155Bile secretion_Homo sapiens_hsa049760.03224109
156TGF-beta signaling pathway_Homo sapiens_hsa043500.02554020
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02515463
158Mineral absorption_Homo sapiens_hsa049780.01462309
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.00757148

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