DNASE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1amino sugar catabolic process (GO:0046348)4.63922821
2oligosaccharide catabolic process (GO:0009313)4.61885181
3glycosphingolipid catabolic process (GO:0046479)4.34321061
4cellular response to thyroid hormone stimulus (GO:0097067)4.01691964
5response to peptidoglycan (GO:0032494)3.92661650
6negative regulation of interleukin-12 production (GO:0032695)3.91162788
7glycolipid catabolic process (GO:0019377)3.86786967
8regulation of mononuclear cell migration (GO:0071675)3.86216035
9response to thyroid hormone (GO:0097066)3.64482049
10immunoglobulin mediated immune response (GO:0016064)3.62016126
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.60777679
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.58637334
13neutrophil activation involved in immune response (GO:0002283)3.57220640
14barbed-end actin filament capping (GO:0051016)3.51238854
15N-acetylneuraminate metabolic process (GO:0006054)3.49033342
16ceramide catabolic process (GO:0046514)3.46270122
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28493543
18NIK/NF-kappaB signaling (GO:0038061)3.13649361
19amyloid precursor protein catabolic process (GO:0042987)3.09328984
20regulation of interferon-beta biosynthetic process (GO:0045357)3.08252869
21regulation of cholesterol storage (GO:0010885)3.05560275
22keratan sulfate catabolic process (GO:0042340)3.03087694
23membrane lipid catabolic process (GO:0046466)3.02784249
24sphingolipid catabolic process (GO:0030149)2.99504049
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99486551
26regulation of antigen processing and presentation (GO:0002577)2.98099222
27virion attachment to host cell (GO:0019062)2.96640624
28adhesion of symbiont to host cell (GO:0044650)2.96640624
29macrophage activation involved in immune response (GO:0002281)2.95164600
30positive regulation of antigen processing and presentation (GO:0002579)2.92771919
31cellular response to type I interferon (GO:0071357)2.92694019
32type I interferon signaling pathway (GO:0060337)2.92694019
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.89917812
34negative regulation of cell killing (GO:0031342)2.89917812
35response to type I interferon (GO:0034340)2.89833745
36T-helper 1 type immune response (GO:0042088)2.89098916
37negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85978106
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84687957
39positive regulation by organism of defense response of other organism involved in symbiotic interact2.84687957
40modulation by symbiont of host immune response (GO:0052553)2.84687957
41positive regulation by symbiont of host defense response (GO:0052509)2.84687957
42modulation by symbiont of host defense response (GO:0052031)2.84687957
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84687957
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84182772
45antigen processing and presentation of endogenous antigen (GO:0019883)2.80904786
46regulation of mast cell degranulation (GO:0043304)2.78645929
47positive regulation of monocyte chemotaxis (GO:0090026)2.78297163
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75586997
49interferon-gamma-mediated signaling pathway (GO:0060333)2.75544945
50positive regulation of lymphocyte apoptotic process (GO:0070230)2.73167244
51pinocytosis (GO:0006907)2.73099837
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71498579
53granulocyte activation (GO:0036230)2.70606448
54adhesion of symbiont to host (GO:0044406)2.69921238
55endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.68585880
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67874358
57phagosome maturation (GO:0090382)2.66579025
58lysosome organization (GO:0007040)2.66229749
59lytic vacuole organization (GO:0080171)2.66229749
60positive regulation of leukocyte degranulation (GO:0043302)2.65657281
61positive regulation of cholesterol efflux (GO:0010875)2.64257471
62myeloid dendritic cell differentiation (GO:0043011)2.64030423
63negative regulation of cytokine production involved in immune response (GO:0002719)2.62554089
64regulation of macrophage chemotaxis (GO:0010758)2.61311988
65mannose metabolic process (GO:0006013)2.61199103
66regulation of superoxide anion generation (GO:0032928)2.59649768
67monocyte chemotaxis (GO:0002548)2.59105376
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.57688475
69detection of other organism (GO:0098543)2.57364169
70regulation of leukocyte degranulation (GO:0043300)2.57245820
71apoptotic cell clearance (GO:0043277)2.56991788
72regulation of interferon-alpha production (GO:0032647)2.56643029
73hydrogen peroxide biosynthetic process (GO:0050665)2.56536190
74negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54660974
75peptide catabolic process (GO:0043171)2.54464306
76regulation of mast cell activation involved in immune response (GO:0033006)2.53250633
77regulation of membrane protein ectodomain proteolysis (GO:0051043)2.50116662
78negative regulation of innate immune response (GO:0045824)2.49818878
79negative regulation of glycoprotein metabolic process (GO:1903019)2.46814841
80Golgi transport vesicle coating (GO:0048200)2.46658020
81COPI coating of Golgi vesicle (GO:0048205)2.46658020
82hyaluronan catabolic process (GO:0030214)2.45229918
83detection of bacterium (GO:0016045)2.44713333
84low-density lipoprotein particle clearance (GO:0034383)2.44459096
85B cell mediated immunity (GO:0019724)2.44234841
86positive regulation of gamma-delta T cell activation (GO:0046645)2.40344997
87regulation of myeloid leukocyte mediated immunity (GO:0002886)2.40233627
88protein localization to endosome (GO:0036010)2.39356440
89regulation of monocyte chemotaxis (GO:0090025)2.39269611
90positive regulation of mast cell activation involved in immune response (GO:0033008)2.39170709
91positive regulation of mast cell degranulation (GO:0043306)2.39170709
92detection of molecule of bacterial origin (GO:0032490)2.38892119
93detection of external biotic stimulus (GO:0098581)2.38802155
94positive regulation of interferon-alpha production (GO:0032727)2.38030548
95positive regulation of chemokine biosynthetic process (GO:0045080)2.36771675
96response to muramyl dipeptide (GO:0032495)2.36221319
97positive regulation of sterol transport (GO:0032373)2.35858038
98positive regulation of cholesterol transport (GO:0032376)2.35858038
99negative regulation of erythrocyte differentiation (GO:0045647)2.35444091
100Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35019143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.09894476
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.58730601
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.19845660
4SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34599986
5VDR_21846776_ChIP-Seq_THP-1_Human2.33993859
6RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.33919048
7LXR_22292898_ChIP-Seq_THP-1_Human2.32279373
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.30723001
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.30065304
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27178911
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25219773
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19976540
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14454531
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02848270
15ELK3_25401928_ChIP-Seq_HUVEC_Human1.97959493
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93351368
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92011284
18STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91125793
19* VDR_24763502_ChIP-Seq_THP-1_Human1.89233474
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.83853706
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83301637
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78610495
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71782652
24RACK7_27058665_Chip-Seq_MCF-7_Human1.71649398
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70237765
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70232585
27MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67407626
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66030351
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65056504
30* SPI1_23547873_ChIP-Seq_NB4_Human1.63630141
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63535077
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.61937722
33* TFEB_21752829_ChIP-Seq_HELA_Human1.61668971
34* SPI1_23127762_ChIP-Seq_K562_Human1.60723309
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60414619
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55039269
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.51733978
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50179001
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.48611395
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48159414
41MAF_26560356_Chip-Seq_TH1_Human1.48140405
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47958606
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44820932
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44091568
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43582844
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43370277
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42724751
48ZNF263_19887448_ChIP-Seq_K562_Human1.42130316
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41361878
50MYC_22102868_ChIP-Seq_BL_Human1.40319267
51CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39956177
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34972370
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34930303
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32764235
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32223468
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32087711
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.30459915
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29971072
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28392467
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28146281
61BCL6_27268052_Chip-Seq_Bcells_Human1.28111986
62MAF_26560356_Chip-Seq_TH2_Human1.27814698
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26661726
64BCOR_27268052_Chip-Seq_Bcells_Human1.26395532
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25915408
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25184381
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24945251
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.24260782
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23285762
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22919039
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21742469
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20941362
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16411276
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15837553
75UTX_26944678_Chip-Seq_JUKART_Human1.14361389
76STAT1_20625510_ChIP-Seq_HELA_Human1.14361097
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13755318
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13174522
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13065253
80VDR_24787735_ChIP-Seq_THP-1_Human1.10613611
81P68_20966046_ChIP-Seq_HELA_Human1.10340903
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.09159505
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09159102
84KDM2B_26808549_Chip-Seq_DND41_Human1.08497268
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.08353251
86TCF7_22412390_ChIP-Seq_EML_Mouse1.07160305
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06696494
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06284300
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.05610343
90ATF3_27146783_Chip-Seq_COLON_Human1.05413408
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05380529
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04884455
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04437296
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04097836
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03189682
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03025272
97NCOR1_26117541_ChIP-Seq_K562_Human1.02519449
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01979145
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01873097
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01006722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.31382703
2MP0009840_abnormal_foam_cell3.58137072
3MP0006082_CNS_inflammation3.32732762
4MP0003172_abnormal_lysosome_physiology3.13470548
5MP0003303_peritoneal_inflammation2.90226761
6MP0003436_decreased_susceptibility_to2.85599221
7MP0003191_abnormal_cellular_cholesterol2.83578657
8MP0002148_abnormal_hypersensitivity_rea2.81850903
9MP0009785_altered_susceptibility_to2.45382042
10MP0002139_abnormal_hepatobiliary_system2.42110212
11MP0005671_abnormal_response_to2.38268612
12MP0001835_abnormal_antigen_presentation2.38097517
13MP0002419_abnormal_innate_immunity2.36370284
14MP0003724_increased_susceptibility_to2.32603063
15MP0000685_abnormal_immune_system2.30415337
16MP0000343_altered_response_to2.27744270
17MP0002254_reproductive_system_inflammat2.25308332
18MP0005025_abnormal_response_to2.21306379
19MP0000604_amyloidosis2.17083861
20MP0005000_abnormal_immune_tolerance2.16013277
21MP0005387_immune_system_phenotype2.12781120
22MP0001790_abnormal_immune_system2.12781120
23MP0003075_altered_response_to2.08901823
24MP0003806_abnormal_nucleotide_metabolis1.99889515
25MP0001533_abnormal_skeleton_physiology1.87241999
26MP0002452_abnormal_antigen_presenting1.84617839
27MP0002723_abnormal_immune_serum1.83468376
28MP0004510_myositis1.81281706
29MP0003300_gastrointestinal_ulcer1.81224581
30MP0005451_abnormal_body_composition1.70742170
31MP0001853_heart_inflammation1.65935310
32MP0004947_skin_inflammation1.62820711
33MP0009333_abnormal_splenocyte_physiolog1.62456073
34MP0001845_abnormal_inflammatory_respons1.60614737
35MP0002420_abnormal_adaptive_immunity1.59362206
36MP0008469_abnormal_protein_level1.59337647
37MP0001800_abnormal_humoral_immune1.58995289
38MP0001819_abnormal_immune_cell1.58793056
39MP0002998_abnormal_bone_remodeling1.55592054
40MP0000858_altered_metastatic_potential1.52135331
41MP0002877_abnormal_melanocyte_morpholog1.48017595
42MP0009764_decreased_sensitivity_to1.44528708
43MP0005310_abnormal_salivary_gland1.42186726
44MP0005464_abnormal_platelet_physiology1.41669422
45MP0002405_respiratory_system_inflammati1.41534842
46MP0003453_abnormal_keratinocyte_physiol1.33787251
47MP0003329_amyloid_beta_deposits1.32227480
48MP0010155_abnormal_intestine_physiology1.31967719
49MP0005365_abnormal_bile_salt1.29782357
50MP0009278_abnormal_bone_marrow1.28154344
51MP0001542_abnormal_bone_strength1.25479172
52MP0005257_abnormal_intraocular_pressure1.22805686
53MP0008260_abnormal_autophagy1.18997736
54MP0003186_abnormal_redox_activity1.18063445
55MP0005165_increased_susceptibility_to1.16440029
56MP0003448_altered_tumor_morphology1.12826072
57MP0000716_abnormal_immune_system1.07509172
58MP0003690_abnormal_glial_cell1.07291331
59MP0001545_abnormal_hematopoietic_system1.05750555
60MP0005397_hematopoietic_system_phenotyp1.05750555
61MP0006054_spinal_hemorrhage1.03837550
62MP0010234_abnormal_vibrissa_follicle1.03137714
63MP0005390_skeleton_phenotype0.97606494
64MP0002138_abnormal_hepatobiliary_system0.96817777
65MP0005166_decreased_susceptibility_to0.94301341
66MP0004019_abnormal_vitamin_homeostasis0.94094071
67MP0008438_abnormal_cutaneous_collagen0.93484082
68MP0003279_aneurysm0.92600696
69MP0003795_abnormal_bone_structure0.90299820
70MP0005319_abnormal_enzyme/_coenzyme0.89519595
71MP0001849_ear_inflammation0.89380724
72MP0002429_abnormal_blood_cell0.88500300
73MP0009763_increased_sensitivity_to0.85689307
74MP0003656_abnormal_erythrocyte_physiolo0.83386954
75MP0000689_abnormal_spleen_morphology0.82558238
76MP0001873_stomach_inflammation0.82140388
77MP0002398_abnormal_bone_marrow0.81930925
78MP0000920_abnormal_myelination0.81104850
79MP0003763_abnormal_thymus_physiology0.80658597
80MP0008875_abnormal_xenobiotic_pharmacok0.79097193
81MP0000609_abnormal_liver_physiology0.76992324
82MP0003828_pulmonary_edema0.76270311
83MP0005164_abnormal_response_to0.76000469
84MP0004858_abnormal_nervous_system0.74418734
85MP0002722_abnormal_immune_system0.74293294
86MP0009643_abnormal_urine_homeostasis0.74013746
87MP0001764_abnormal_homeostasis0.72346376
88MP0005023_abnormal_wound_healing0.72037231
89MP0003705_abnormal_hypodermis_morpholog0.69596646
90MP0001851_eye_inflammation0.68497464
91MP0000681_abnormal_thyroid_gland0.67397302
92MP0000371_diluted_coat_color0.67256418
93MP0002933_joint_inflammation0.67084492
94MP0003634_abnormal_glial_cell0.67008267
95MP0001663_abnormal_digestive_system0.66949195
96MP0002277_abnormal_respiratory_mucosa0.64895940
97MP0001881_abnormal_mammary_gland0.64884827
98MP0001216_abnormal_epidermal_layer0.64334372
99MP0002876_abnormal_thyroid_physiology0.63446766
100MP0002090_abnormal_vision0.63157847

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)8.10217348
2Abnormality of liposaccharide metabolism (HP:0010968)8.10217348
3Abnormality of glycosphingolipid metabolism (HP:0004343)8.10217348
4Vacuolated lymphocytes (HP:0001922)5.61182052
5Increased cerebral lipofuscin (HP:0011813)5.31234159
6Dysostosis multiplex (HP:0000943)5.15524214
7Loss of speech (HP:0002371)4.49440508
8Systemic lupus erythematosus (HP:0002725)4.44565643
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.44013289
10Abnormality of macrophages (HP:0004311)4.41364743
11Abnormality of polysaccharide metabolism (HP:0011012)4.22807997
12Abnormality of glycosaminoglycan metabolism (HP:0004371)4.22807997
13Abnormality of mucopolysaccharide metabolism (HP:0011020)4.22807997
14Urinary glycosaminoglycan excretion (HP:0003541)4.06706576
15Mucopolysacchariduria (HP:0008155)4.06706576
16Progressive neurologic deterioration (HP:0002344)3.44198525
17Axonal loss (HP:0003447)3.32199989
18Recurrent abscess formation (HP:0002722)3.26712657
19Disinhibition (HP:0000734)3.18926170
20Recurrent bacterial skin infections (HP:0005406)3.10997663
21Vertebral compression fractures (HP:0002953)3.05066552
22Nuclear cataract (HP:0100018)3.01253932
23Eczematoid dermatitis (HP:0000976)2.99598592
24Mutism (HP:0002300)2.96670348
25Prolonged neonatal jaundice (HP:0006579)2.96343615
26Autoimmune thrombocytopenia (HP:0001973)2.83322439
27Glomerulonephritis (HP:0000099)2.81369146
28Neurofibrillary tangles (HP:0002185)2.72323988
29Increased serum ferritin (HP:0003281)2.58536894
30Orchitis (HP:0100796)2.57141629
31Myositis (HP:0100614)2.50874994
32Recurrent gram-negative bacterial infections (HP:0005420)2.50412194
33J-shaped sella turcica (HP:0002680)2.49247542
34Purpura (HP:0000979)2.46369899
35Mediastinal lymphadenopathy (HP:0100721)2.44009932
36Hepatosplenomegaly (HP:0001433)2.43116360
37Cardiomegaly (HP:0001640)2.40549910
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37112403
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.35943188
40Amyloidosis (HP:0011034)2.33330578
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32199882
42Petechiae (HP:0000967)2.29256687
43Complement deficiency (HP:0004431)2.23216362
44Diminished motivation (HP:0000745)2.20074335
45Retrobulbar optic neuritis (HP:0100654)2.19317296
46Optic neuritis (HP:0100653)2.19317296
47Retinal atrophy (HP:0001105)2.17222050
48Chronic obstructive pulmonary disease (HP:0006510)2.14983675
49Obstructive lung disease (HP:0006536)2.14983675
50Myocardial infarction (HP:0001658)2.13467254
51Apathy (HP:0000741)2.11916115
52Joint stiffness (HP:0001387)2.07335011
53Abnormality of complement system (HP:0005339)2.02268346
54Abnormality of iron homeostasis (HP:0011031)1.99365830
55Stomatitis (HP:0010280)1.97850716
56Upper motor neuron abnormality (HP:0002127)1.95182680
57Urticaria (HP:0001025)1.94192627
58Recurrent skin infections (HP:0001581)1.94008310
59Neuronal loss in central nervous system (HP:0002529)1.93801746
60Bone cyst (HP:0012062)1.93039237
61Cerebral inclusion bodies (HP:0100314)1.92778159
62Increased CSF protein (HP:0002922)1.92537268
63Thoracic kyphosis (HP:0002942)1.89817046
64Increased IgM level (HP:0003496)1.89663972
65Interstitial pulmonary disease (HP:0006530)1.89118032
66Pulmonary infiltrates (HP:0002113)1.88284983
67Abnormality of the nasal mucosa (HP:0000433)1.88177798
68Hypokinesia (HP:0002375)1.87680098
69Bone pain (HP:0002653)1.87419320
70Asymmetric septal hypertrophy (HP:0001670)1.86761065
71Hematochezia (HP:0002573)1.86640292
72Dementia (HP:0000726)1.86551094
73Pathologic fracture (HP:0002756)1.83739688
74Cervical subluxation (HP:0003308)1.83723177
75Neoplasm of head and neck (HP:0012288)1.78477714
76Esophageal neoplasm (HP:0100751)1.78477714
77Hypertensive crisis (HP:0100735)1.75622626
78Xanthomatosis (HP:0000991)1.74867021
79Elevated erythrocyte sedimentation rate (HP:0003565)1.74028708
80Malnutrition (HP:0004395)1.74010330
81Nephritis (HP:0000123)1.73230977
82Restrictive lung disease (HP:0002091)1.72416832
83Ovoid vertebral bodies (HP:0003300)1.70649101
84Abnormality of pyrimidine metabolism (HP:0004353)1.70405156
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70195278
86Polyneuropathy (HP:0001271)1.68854409
87Rough bone trabeculation (HP:0100670)1.68614211
88Prostate neoplasm (HP:0100787)1.67620790
89Personality changes (HP:0000751)1.64475559
90Premature rupture of membranes (HP:0001788)1.64178491
91Recurrent fungal infections (HP:0002841)1.63373654
92Vasculitis (HP:0002633)1.62577934
93Abnormality of the distal phalanges of the toes (HP:0010182)1.61415470
94Gastrointestinal stroma tumor (HP:0100723)1.60791490
95Hemoptysis (HP:0002105)1.60665470
96Albinism (HP:0001022)1.59895163
97Abnormality of transition element cation homeostasis (HP:0011030)1.59338245
98Basal ganglia calcification (HP:0002135)1.58945354
99Premature loss of primary teeth (HP:0006323)1.57820575
100Abnormal trabecular bone morphology (HP:0100671)1.56234758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.09354902
2IRAK33.68669080
3ERN13.28413051
4MAP4K13.20316510
5TAOK33.19512290
6TXK2.95662025
7TESK22.81273523
8TBK12.62009628
9TESK12.58693942
10BCKDK2.54060964
11BLK2.13331794
12TYK21.94403622
13MAP3K141.94201798
14PIM21.93283339
15TRIB31.79876257
16PRPF4B1.77180702
17TGFBR21.75663327
18IKBKB1.72990838
19TAOK21.67998421
20MAP3K31.65170293
21IKBKE1.56893405
22ZAP701.56711707
23ARAF1.54769989
24GRK71.54410018
25MAP3K111.51532570
26ABL21.46278677
27MAP2K31.44837458
28LIMK11.44304107
29IRAK41.43980295
30SIK11.39237956
31MAPKAPK31.31542766
32DDR21.29246267
33PAK41.27334106
34JAK31.25960805
35CSK1.25126799
36EPHA21.18126566
37MATK1.13312169
38JAK11.09373256
39RIPK41.06175927
40RIPK11.01746354
41MOS0.99801730
42CSF1R0.97811876
43TAOK10.93031844
44SMG10.92933635
45MAP3K130.90432455
46PDK20.86849283
47GRK60.83509944
48EPHB10.83189071
49MAP2K20.82773845
50TNK20.81258520
51MAP3K10.80826119
52CDC42BPA0.80565527
53PRKD20.78176245
54FGR0.76378146
55LYN0.75610156
56CHUK0.71902491
57MAP2K60.71700370
58KIT0.69776864
59ADRBK20.68980425
60SYK0.64795609
61FES0.64287906
62PDPK10.62577178
63LCK0.61691836
64HCK0.61244966
65NEK90.60285118
66IRAK10.60012555
67TLK10.58761118
68CAMKK20.58220521
69IRAK20.58161680
70MAPKAPK20.57545148
71STK100.56068463
72CAMK1D0.55517567
73RPS6KA20.54446973
74PTK60.49901576
75JAK20.49317449
76LRRK20.48693952
77HIPK20.48491334
78MARK30.48239463
79STK160.48193892
80BTK0.47350436
81KDR0.45416182
82ICK0.41298683
83DAPK30.41013170
84PKN20.40781955
85EPHB20.39408994
86LMTK20.39382254
87PRKG20.38901204
88RPS6KL10.37991160
89RPS6KC10.37991160
90FGFR40.36684258
91VRK20.34951977
92BMX0.34558468
93PRKCI0.34053268
94ITK0.33705741
95BRAF0.32158007
96MAP3K80.31816154
97BMPR20.29871043
98RPS6KA60.29546091
99MAPK70.29531234
100PIM10.28719446

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005115.22219333
2* Lysosome_Homo sapiens_hsa041423.96969991
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.67679562
4Staphylococcus aureus infection_Homo sapiens_hsa051502.94484245
5Rheumatoid arthritis_Homo sapiens_hsa053232.55865147
6Allograft rejection_Homo sapiens_hsa053302.33863142
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23661389
8Osteoclast differentiation_Homo sapiens_hsa043802.22150136
9Autoimmune thyroid disease_Homo sapiens_hsa053202.17568240
10Leishmaniasis_Homo sapiens_hsa051402.13332755
11Asthma_Homo sapiens_hsa053102.09653211
12Graft-versus-host disease_Homo sapiens_hsa053322.02090298
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.99197963
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88735594
15Antigen processing and presentation_Homo sapiens_hsa046121.81737266
16Tuberculosis_Homo sapiens_hsa051521.78666129
17Phagosome_Homo sapiens_hsa041451.71922774
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70134382
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65518315
20Galactose metabolism_Homo sapiens_hsa000521.63802017
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63465446
22Type I diabetes mellitus_Homo sapiens_hsa049401.62705974
23Collecting duct acid secretion_Homo sapiens_hsa049661.61374686
24Pertussis_Homo sapiens_hsa051331.59469275
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.54133937
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51566123
27Malaria_Homo sapiens_hsa051441.51300194
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43104228
29Vibrio cholerae infection_Homo sapiens_hsa051101.36533223
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32795849
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.25742466
32TNF signaling pathway_Homo sapiens_hsa046681.21940114
33Toxoplasmosis_Homo sapiens_hsa051451.19969676
34Prion diseases_Homo sapiens_hsa050201.15194379
35Salmonella infection_Homo sapiens_hsa051321.14219101
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13921950
37Legionellosis_Homo sapiens_hsa051341.10020428
38Viral myocarditis_Homo sapiens_hsa054161.09613265
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.09122752
40Sphingolipid metabolism_Homo sapiens_hsa006001.05637514
41Hematopoietic cell lineage_Homo sapiens_hsa046401.05493321
42Sulfur metabolism_Homo sapiens_hsa009201.02285009
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00739233
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99170506
45Influenza A_Homo sapiens_hsa051640.99003948
46Complement and coagulation cascades_Homo sapiens_hsa046100.95837138
47Hepatitis C_Homo sapiens_hsa051600.92374481
48B cell receptor signaling pathway_Homo sapiens_hsa046620.88920740
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88755790
50Herpes simplex infection_Homo sapiens_hsa051680.85123697
51Pentose phosphate pathway_Homo sapiens_hsa000300.85076173
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83913031
53Bladder cancer_Homo sapiens_hsa052190.83205514
54Apoptosis_Homo sapiens_hsa042100.82990465
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82840695
56Fructose and mannose metabolism_Homo sapiens_hsa000510.82354557
57Shigellosis_Homo sapiens_hsa051310.78734774
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77209725
59Measles_Homo sapiens_hsa051620.76162272
60Mineral absorption_Homo sapiens_hsa049780.75200849
61Primary immunodeficiency_Homo sapiens_hsa053400.72475694
62Fatty acid elongation_Homo sapiens_hsa000620.64238843
63Acute myeloid leukemia_Homo sapiens_hsa052210.60384381
64Glutathione metabolism_Homo sapiens_hsa004800.56877858
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.55090970
66Oxidative phosphorylation_Homo sapiens_hsa001900.52039146
67Hepatitis B_Homo sapiens_hsa051610.50328101
68PPAR signaling pathway_Homo sapiens_hsa033200.49733863
69Endocytosis_Homo sapiens_hsa041440.49557493
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.49351808
71Chemokine signaling pathway_Homo sapiens_hsa040620.47329323
72T cell receptor signaling pathway_Homo sapiens_hsa046600.42679348
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42263084
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41182278
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40781342
76Sulfur relay system_Homo sapiens_hsa041220.40284229
77Amoebiasis_Homo sapiens_hsa051460.39971476
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39368502
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.39117184
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38596443
81Tryptophan metabolism_Homo sapiens_hsa003800.37766529
82Notch signaling pathway_Homo sapiens_hsa043300.37307110
83Epstein-Barr virus infection_Homo sapiens_hsa051690.36403994
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.36274674
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35338839
86Folate biosynthesis_Homo sapiens_hsa007900.34825815
87N-Glycan biosynthesis_Homo sapiens_hsa005100.33019593
88African trypanosomiasis_Homo sapiens_hsa051430.32307897
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31767229
90Systemic lupus erythematosus_Homo sapiens_hsa053220.30630011
91VEGF signaling pathway_Homo sapiens_hsa043700.26500503
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26016830
93HTLV-I infection_Homo sapiens_hsa051660.24339937
94Vitamin B6 metabolism_Homo sapiens_hsa007500.22657078
95Prolactin signaling pathway_Homo sapiens_hsa049170.21339850
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21211450
97Arachidonic acid metabolism_Homo sapiens_hsa005900.20233298
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19650663
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19072739
100Pancreatic cancer_Homo sapiens_hsa052120.17749812

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