DNASE2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)9.82570586
2oligosaccharide catabolic process (GO:0009313)9.16356731
3glycosphingolipid catabolic process (GO:0046479)8.91527646
4positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)8.81540130
5sulfur amino acid catabolic process (GO:0000098)8.58883037
6glycolipid catabolic process (GO:0019377)8.01803582
7amino sugar catabolic process (GO:0046348)7.96990189
8glucosamine-containing compound catabolic process (GO:1901072)7.34342517
9ceramide catabolic process (GO:0046514)7.21525854
10iron ion import (GO:0097286)6.97442590
11regulation of cholesterol storage (GO:0010885)6.32747316
12positive regulation of bone resorption (GO:0045780)6.15035615
13positive regulation of bone remodeling (GO:0046852)6.15035615
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.11039301
15L-phenylalanine catabolic process (GO:0006559)6.11039301
16serine family amino acid catabolic process (GO:0009071)6.04917716
17regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.95754616
18L-phenylalanine metabolic process (GO:0006558)5.76985528
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.76985528
20ganglioside metabolic process (GO:0001573)5.54449278
21cellular response to thyroid hormone stimulus (GO:0097067)5.51035979
22aromatic amino acid family catabolic process (GO:0009074)5.20196433
23sphingolipid catabolic process (GO:0030149)5.13493445
24membrane lipid catabolic process (GO:0046466)5.00835050
25kynurenine metabolic process (GO:0070189)4.91639682
26creatine metabolic process (GO:0006600)4.91008619
27cellular modified amino acid catabolic process (GO:0042219)4.90162009
28ectodermal placode formation (GO:0060788)4.85964918
29valine metabolic process (GO:0006573)4.83323071
30response to thyroid hormone (GO:0097066)4.78656963
31glutamate metabolic process (GO:0006536)4.76683436
32osteoclast differentiation (GO:0030316)4.74974798
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.74846641
34serine family amino acid metabolic process (GO:0009069)4.72926588
35bile acid biosynthetic process (GO:0006699)4.64921172
36alpha-linolenic acid metabolic process (GO:0036109)4.64483628
37tryptophan catabolic process (GO:0006569)4.62363697
38indole-containing compound catabolic process (GO:0042436)4.62363697
39indolalkylamine catabolic process (GO:0046218)4.62363697
40regulation of monocyte differentiation (GO:0045655)4.52793061
41protein carboxylation (GO:0018214)4.51072768
42peptidyl-glutamic acid carboxylation (GO:0017187)4.51072768
43tryptophan metabolic process (GO:0006568)4.49201351
44high-density lipoprotein particle remodeling (GO:0034375)4.44439630
45urea cycle (GO:0000050)4.41006310
46urea metabolic process (GO:0019627)4.41006310
47glyoxylate metabolic process (GO:0046487)4.36716333
48very-low-density lipoprotein particle assembly (GO:0034379)4.35221482
49negative regulation of fibrinolysis (GO:0051918)4.35157728
50complement activation, alternative pathway (GO:0006957)4.31543586
51lysine metabolic process (GO:0006553)4.30938576
52lysine catabolic process (GO:0006554)4.30938576
53mannose metabolic process (GO:0006013)4.29346087
54oxaloacetate metabolic process (GO:0006107)4.23924639
55trivalent inorganic cation transport (GO:0072512)4.21524928
56ferric iron transport (GO:0015682)4.21524928
57cellular amino acid catabolic process (GO:0009063)4.20340784
58regulation of protein activation cascade (GO:2000257)4.19291406
59N-acetylneuraminate metabolic process (GO:0006054)4.18987020
60endocardial cushion morphogenesis (GO:0003203)4.17546176
61serine family amino acid biosynthetic process (GO:0009070)4.16299433
62response to lipoprotein particle (GO:0055094)4.13237220
632-oxoglutarate metabolic process (GO:0006103)4.13077496
64fat-soluble vitamin biosynthetic process (GO:0042362)4.11492830
65regulation of fibrinolysis (GO:0051917)4.09629861
66alpha-amino acid catabolic process (GO:1901606)4.05803236
67intracellular pH reduction (GO:0051452)4.04984020
68peptide catabolic process (GO:0043171)4.01528495
69nitrogen cycle metabolic process (GO:0071941)3.99868253
70homocysteine metabolic process (GO:0050667)3.94853675
71regulation of complement activation (GO:0030449)3.94137410
72anterior/posterior axis specification, embryo (GO:0008595)3.90747256
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.86526827
74positive regulation of monocyte chemotaxis (GO:0090026)3.86505096
75positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.85816095
76pH reduction (GO:0045851)3.85148845
77keratan sulfate catabolic process (GO:0042340)3.85142509
78bile acid metabolic process (GO:0008206)3.84409314
79reverse cholesterol transport (GO:0043691)3.84178661
80transferrin transport (GO:0033572)3.75725030
81positive regulation of tissue remodeling (GO:0034105)3.71902163
82aromatic amino acid family metabolic process (GO:0009072)3.69883561
83protein-lipid complex remodeling (GO:0034368)3.68233406
84macromolecular complex remodeling (GO:0034367)3.68233406
85plasma lipoprotein particle remodeling (GO:0034369)3.68233406
86regulation of triglyceride catabolic process (GO:0010896)3.65847918
87response to nitrosative stress (GO:0051409)3.63653811
88amino-acid betaine metabolic process (GO:0006577)3.62248231
89tyrosine metabolic process (GO:0006570)3.59959661
90negative regulation of lipase activity (GO:0060192)3.59594258
91regulation of plasminogen activation (GO:0010755)3.59368253
92negative regulation of sterol transport (GO:0032372)3.58437658
93negative regulation of cholesterol transport (GO:0032375)3.58437658
94phagosome maturation (GO:0090382)3.57067376
95ethanol oxidation (GO:0006069)3.52966336
96barbed-end actin filament capping (GO:0051016)3.51458787
97regulation of cholesterol esterification (GO:0010872)3.51118540
98dicarboxylic acid biosynthetic process (GO:0043650)3.50793145
99sulfur amino acid metabolic process (GO:0000096)3.48093145
100apoptotic cell clearance (GO:0043277)3.44031276
101coenzyme catabolic process (GO:0009109)3.42533757
102carboxylic acid catabolic process (GO:0046395)3.42367411
103organic acid catabolic process (GO:0016054)3.42367411
104glycine metabolic process (GO:0006544)3.41371449
105positive regulation of osteoclast differentiation (GO:0045672)3.41279798
106vitamin D metabolic process (GO:0042359)3.39733869
107cellular ketone body metabolic process (GO:0046950)3.38027266
108regulation of macrophage derived foam cell differentiation (GO:0010743)3.37730190
109short-chain fatty acid metabolic process (GO:0046459)3.37154535
110epithelial cell differentiation involved in prostate gland development (GO:0060742)3.35586650
111COPI coating of Golgi vesicle (GO:0048205)3.33160862
112Golgi transport vesicle coating (GO:0048200)3.33160862
113phospholipid efflux (GO:0033700)3.33147068
114lipoprotein metabolic process (GO:0042157)3.32617374
115sodium-independent organic anion transport (GO:0043252)3.32291574
116benzene-containing compound metabolic process (GO:0042537)3.32131679
117fibrinolysis (GO:0042730)3.32126409
118energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.32056500
119ATP hydrolysis coupled proton transport (GO:0015991)3.32056500
120fructose metabolic process (GO:0006000)3.31156960
121hormone catabolic process (GO:0042447)3.29967886
122positive regulation of leukocyte degranulation (GO:0043302)3.29600959
123regulation of cholesterol homeostasis (GO:2000188)3.29401465
124bile acid and bile salt transport (GO:0015721)3.29311197
125acylglycerol homeostasis (GO:0055090)3.29077699
126triglyceride homeostasis (GO:0070328)3.29077699
127iron ion transport (GO:0006826)3.27106428
128branched-chain amino acid metabolic process (GO:0009081)3.27002748
129positive regulation of mast cell activation (GO:0033005)3.26302896
130cholesterol efflux (GO:0033344)3.26247592
131neutrophil activation involved in immune response (GO:0002283)3.25639173
132indolalkylamine metabolic process (GO:0006586)3.25510380
133aspartate family amino acid catabolic process (GO:0009068)3.23233003
134regulation of receptor binding (GO:1900120)3.22796041
135regulation of bone resorption (GO:0045124)3.22107262
136N-glycan processing (GO:0006491)3.21011260
137regulation of mononuclear cell migration (GO:0071675)3.20722300
138plasma lipoprotein particle clearance (GO:0034381)3.20146828
139negative regulation of erythrocyte differentiation (GO:0045647)3.19885898
140arginine metabolic process (GO:0006525)3.19850492
141positive regulation of fatty acid beta-oxidation (GO:0032000)3.14210722
142sulfur amino acid biosynthetic process (GO:0000097)3.13575264
143mesenchyme morphogenesis (GO:0072132)3.13455138
144pyrimidine-containing compound transmembrane transport (GO:0072531)3.12868296
145negative regulation of nitric oxide biosynthetic process (GO:0045019)3.12863618
146low-density lipoprotein particle remodeling (GO:0034374)3.10547157
147cellular glucuronidation (GO:0052695)3.09100105
148positive regulation of lipid catabolic process (GO:0050996)3.08091724
149cytolysis (GO:0019835)3.04686286
150myeloid dendritic cell differentiation (GO:0043011)3.03757700
151acetyl-CoA metabolic process (GO:0006084)3.02762417
152glutamine family amino acid biosynthetic process (GO:0009084)3.02675454
153succinate metabolic process (GO:0006105)3.01731744
154positive regulation of mast cell degranulation (GO:0043306)3.00127495
155positive regulation of mast cell activation involved in immune response (GO:0033008)3.00127495
156response to acidic pH (GO:0010447)2.99837841
157amine catabolic process (GO:0009310)2.99737384
158lipoprotein transport (GO:0042953)2.99204319
159amyloid precursor protein catabolic process (GO:0042987)2.97548570
160nucleoside transmembrane transport (GO:1901642)2.95298535
161negative regulation of lipid storage (GO:0010888)2.93011593
162import into cell (GO:0098657)2.89524691
163eosinophil chemotaxis (GO:0048245)2.89346593
164positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.88771112
165negative regulation of interleukin-12 production (GO:0032695)2.88036602
166regulation of superoxide anion generation (GO:0032928)2.87590180
167positive regulation of cholesterol efflux (GO:0010875)2.86846528
168response to peptidoglycan (GO:0032494)2.86175796
169regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82961103
170negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82246455
171positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.82038468
172lipid storage (GO:0019915)2.75060024
173angiotensin maturation (GO:0002003)2.74406281
174branching involved in prostate gland morphogenesis (GO:0060442)2.71979956
175lytic vacuole organization (GO:0080171)2.71942711
176lysosome organization (GO:0007040)2.71942711
177regulation of intracellular pH (GO:0051453)2.71638018
178cellular extravasation (GO:0045123)2.71127413
179positive regulation of cellular amide metabolic process (GO:0034250)2.70571034
180positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.69076810
181positive regulation of macrophage cytokine production (GO:0060907)2.68970138
182biotin metabolic process (GO:0006768)2.67596442
183copper ion transport (GO:0006825)2.65364646
184regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.65172832
185regulation of cellular pH (GO:0030641)2.63650902
186stress fiber assembly (GO:0043149)2.63614639
187glycosphingolipid metabolic process (GO:0006687)2.61172891
188cellular iron ion homeostasis (GO:0006879)2.59011106
189plasma lipoprotein particle assembly (GO:0034377)2.58174658
190protein-lipid complex assembly (GO:0065005)2.55863995
191amino sugar metabolic process (GO:0006040)2.55125162
192positive regulation of macrophage differentiation (GO:0045651)2.54883807
193eosinophil migration (GO:0072677)2.54396320
194regulation of monocyte chemotaxis (GO:0090025)2.53319189
195alanine transport (GO:0032328)2.53128156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.89828269
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.21192498
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.48105718
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.32921331
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.10878670
6IRF8_21731497_ChIP-ChIP_J774_Mouse5.10861552
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.20214210
8EGR1_23403033_ChIP-Seq_LIVER_Mouse4.19435988
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.14985804
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.83654950
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61151284
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.55249946
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42182352
14ZNF263_19887448_ChIP-Seq_K562_Human3.21672616
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.04887283
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04618367
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00442978
18VDR_24787735_ChIP-Seq_THP-1_Human2.59661274
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.32579056
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21828505
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10788189
22TFEB_21752829_ChIP-Seq_HELA_Human1.99501236
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.96147098
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.89497298
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86901674
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81107002
27CLOCK_20551151_ChIP-Seq_293T_Human1.80999314
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80528033
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77520832
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67899019
31SPI1_23127762_ChIP-Seq_K562_Human1.64630892
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64121645
33VDR_24763502_ChIP-Seq_THP-1_Human1.61495542
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60573132
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60540544
36PU_27001747_Chip-Seq_BMDM_Mouse1.60139195
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58330184
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54917114
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50420253
40SPI1_23547873_ChIP-Seq_NB4_Human1.50199064
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.49807572
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49118341
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.45780202
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44329777
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43991459
46GATA4_25053715_ChIP-Seq_YYC3_Human1.39754212
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39439756
48AR_21909140_ChIP-Seq_LNCAP_Human1.38183672
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36870215
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36130653
51SCL_19346495_ChIP-Seq_HPC-7_Human1.33195994
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31419768
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27434251
54RACK7_27058665_Chip-Seq_MCF-7_Human1.27350090
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.27345183
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27237674
57CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26561856
58SOX2_20726797_ChIP-Seq_SW620_Human1.26161001
59GATA6_25053715_ChIP-Seq_YYC3_Human1.25164525
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23791236
61* STAT1_20625510_ChIP-Seq_HELA_Human1.23657454
62AR_21572438_ChIP-Seq_LNCaP_Human1.22370722
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22103376
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.21352840
65MITF_21258399_ChIP-Seq_MELANOMA_Human1.19766202
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19002488
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17965830
68* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16922983
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.16148236
70VDR_21846776_ChIP-Seq_THP-1_Human1.16041594
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15337995
72* CHD1_26751641_Chip-Seq_LNCaP_Human1.14852371
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14742114
74CDX2_20551321_ChIP-Seq_CACO-2_Human1.14512869
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14180969
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.13419587
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13123169
78* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11378823
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.10737510
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10391481
81STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09687794
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08911226
83AHR_22903824_ChIP-Seq_MCF-7_Human1.08781763
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08416652
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07361624
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.02752096
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01939230
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01378507
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.99853073
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99092477
91IRF1_19129219_ChIP-ChIP_H3396_Human0.98802878
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98548764
93STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98181754
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98085199
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97661926
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95944573
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95934261
98GATA1_22025678_ChIP-Seq_K562_Human0.95207573
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92941311
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90658202
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90658202
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90658202
103LXR_22292898_ChIP-Seq_THP-1_Human0.90023847
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89605484
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89526958
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86551253
107NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85372131
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85372131
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85291714
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85136586
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83858970
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82922292
113CREB1_26743006_Chip-Seq_LNCaP_Human0.82379008
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.81464310
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81003165
116* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80563733
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.79786562
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79384918
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78289156
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77639716
121TBX20_22080862_ChIP-Seq_HEART_Mouse0.77579532
122TBX20_22328084_ChIP-Seq_HEART_Mouse0.77579532
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.76176531
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76047412
125* FOXA1_25552417_ChIP-Seq_VCAP_Human0.75626683
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75537130
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75488182
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74937245
129SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74628519
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74447639
131BP1_19119308_ChIP-ChIP_Hs578T_Human0.74350101
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73628833
133* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.73191844
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72926553
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72505755
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71897779
137GATA2_19941826_ChIP-Seq_K562_Human0.71893001
138ATF3_27146783_Chip-Seq_COLON_Human0.70388148
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70109085
140RXRA_24833708_ChIP-Seq_LIVER_Mouse0.69410751
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.67568333
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67230084
143GATA1_19941826_ChIP-Seq_K562_Human0.66896067
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.66099953
145KDM2B_26808549_Chip-Seq_K562_Human0.65964086
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65928913
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65394297
148* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65035823
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.64089442
150BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63396341
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.63039918
152Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62030029
153PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.60369275
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.60111153
155TET1_21451524_ChIP-Seq_MESCs_Mouse0.59688107
156KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.59531369
157MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.59328856
158ZFP281_18757296_ChIP-ChIP_E14_Mouse0.58909062
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.58740903
160MYC_27129775_Chip-Seq_CORNEA_Mouse0.58455556
161IRF8_22096565_ChIP-ChIP_GC-B_Human0.57946447
162EP300_21415370_ChIP-Seq_HL-1_Mouse0.57409620
163SMAD_19615063_ChIP-ChIP_OVARY_Human0.57286418
164CBP_21632823_ChIP-Seq_H3396_Human0.57216498
165TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56407398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.22449483
2MP0005360_urolithiasis6.43420089
3MP0005085_abnormal_gallbladder_physiolo5.25105392
4MP0005365_abnormal_bile_salt5.24847346
5MP0003172_abnormal_lysosome_physiology4.12714771
6MP0008875_abnormal_xenobiotic_pharmacok3.85628394
7MP0005310_abnormal_salivary_gland3.41035053
8MP0003252_abnormal_bile_duct3.36302560
9MP0001666_abnormal_nutrient_absorption3.01417766
10MP0010329_abnormal_lipoprotein_level3.00327293
11MP0003806_abnormal_nucleotide_metabolis2.98513016
12MP0003195_calcinosis2.94910125
13MP0003724_increased_susceptibility_to2.78462587
14MP0004185_abnormal_adipocyte_glucose2.73926781
15MP0006082_CNS_inflammation2.71256952
16MP0005332_abnormal_amino_acid2.65662967
17MP0009840_abnormal_foam_cell2.51801931
18MP0005319_abnormal_enzyme/_coenzyme2.12701505
19MP0003705_abnormal_hypodermis_morpholog2.10284420
20MP0002148_abnormal_hypersensitivity_rea2.02024119
21MP0002419_abnormal_innate_immunity1.98008564
22MP0000609_abnormal_liver_physiology1.92850289
23MP0005083_abnormal_biliary_tract1.92423121
24MP0005167_abnormal_blood-brain_barrier1.89651441
25MP0005220_abnormal_exocrine_pancreas1.87702551
26MP0004264_abnormal_extraembryonic_tissu1.85915012
27MP0000343_altered_response_to1.84385190
28MP0004019_abnormal_vitamin_homeostasis1.80862738
29MP0002118_abnormal_lipid_homeostasis1.80424277
30MP0003191_abnormal_cellular_cholesterol1.79384456
31MP0005058_abnormal_lysosome_morphology1.70518491
32MP0000537_abnormal_urethra_morphology1.70405597
33MP0003868_abnormal_feces_composition1.68279739
34MP0002998_abnormal_bone_remodeling1.66647061
35MP0001756_abnormal_urination1.64571247
36MP0002877_abnormal_melanocyte_morpholog1.62768427
37MP0003879_abnormal_hair_cell1.60370744
38MP0005636_abnormal_mineral_homeostasis1.59091196
39MP0003656_abnormal_erythrocyte_physiolo1.56303244
40MP0001835_abnormal_antigen_presentation1.54936539
41MP0003075_altered_response_to1.54850084
42MP0002138_abnormal_hepatobiliary_system1.54480766
43MP0009643_abnormal_urine_homeostasis1.54473692
44MP0005671_abnormal_response_to1.53372301
45MP0001727_abnormal_embryo_implantation1.52680609
46MP0000920_abnormal_myelination1.48540042
47MP0004858_abnormal_nervous_system1.42522454
48MP0010234_abnormal_vibrissa_follicle1.39182665
49MP0000516_abnormal_urinary_system1.38547552
50MP0005367_renal/urinary_system_phenotyp1.38547552
51MP0003303_peritoneal_inflammation1.35273316
52MP0001765_abnormal_ion_homeostasis1.34299765
53MP0000579_abnormal_nail_morphology1.33638339
54MP0003183_abnormal_peptide_metabolism1.33042170
55MP0003011_delayed_dark_adaptation1.32426964
56MP0005584_abnormal_enzyme/coenzyme_acti1.31714289
57MP0002653_abnormal_ependyma_morphology1.30416579
58MP0001881_abnormal_mammary_gland1.26186183
59MP0002452_abnormal_antigen_presenting1.26126490
60MP0004233_abnormal_muscle_weight1.23430499
61MP0005397_hematopoietic_system_phenotyp1.22986209
62MP0001545_abnormal_hematopoietic_system1.22986209
63MP0001853_heart_inflammation1.22332898
64MP0003633_abnormal_nervous_system1.20871359
65MP0005025_abnormal_response_to1.20377630
66MP0003632_abnormal_nervous_system1.19998660
67MP0001764_abnormal_homeostasis1.19414872
68MP0005410_abnormal_fertilization1.18204218
69MP0005666_abnormal_adipose_tissue1.17005498
70MP0004742_abnormal_vestibular_system1.16005404
71MP0000534_abnormal_ureter_morphology1.15895468
72MP0005646_abnormal_pituitary_gland1.15625034
73MP0009115_abnormal_fat_cell1.14711489
74MP0000598_abnormal_liver_morphology1.14433351
75MP0009785_altered_susceptibility_to1.12436060
76MP0003634_abnormal_glial_cell1.10037201
77MP0005000_abnormal_immune_tolerance1.09845263
78MP0000569_abnormal_digit_pigmentation1.09421434
79MP0003436_decreased_susceptibility_to1.08512761
80MP0002229_neurodegeneration1.06628260
81MP0003631_nervous_system_phenotype1.06281127
82MP0004130_abnormal_muscle_cell1.05427446
83MP0002876_abnormal_thyroid_physiology1.04714255
84MP0003950_abnormal_plasma_membrane1.02772564
85* MP0002090_abnormal_vision1.02109121
86MP0001845_abnormal_inflammatory_respons1.02097862
87MP0009764_decreased_sensitivity_to0.98208870
88MP0001790_abnormal_immune_system0.93805730
89MP0005387_immune_system_phenotype0.93805730
90MP0000538_abnormal_urinary_bladder0.93351516
91MP0005464_abnormal_platelet_physiology0.92724593
92MP0001533_abnormal_skeleton_physiology0.91383630
93MP0002971_abnormal_brown_adipose0.89974082
94MP0003690_abnormal_glial_cell0.89715827
95MP0010678_abnormal_skin_adnexa0.89681086
96MP0008469_abnormal_protein_level0.89616170
97MP0002078_abnormal_glucose_homeostasis0.89470601
98MP0009333_abnormal_splenocyte_physiolog0.89366576
99MP0001984_abnormal_olfaction0.88978024
100MP0002254_reproductive_system_inflammat0.88566875
101MP0009642_abnormal_blood_homeostasis0.87699736
102MP0000627_abnormal_mammary_gland0.87365850
103MP0002723_abnormal_immune_serum0.86123118
104MP0002837_dystrophic_cardiac_calcinosis0.84955090
105MP0010307_abnormal_tumor_latency0.84129750
106MP0003300_gastrointestinal_ulcer0.83988905
107MP0000015_abnormal_ear_pigmentation0.81605513
108MP0003453_abnormal_keratinocyte_physiol0.81322896
109MP0005248_abnormal_Harderian_gland0.81297358
110MP0009278_abnormal_bone_marrow0.80984534
111MP0000681_abnormal_thyroid_gland0.79414102
112MP0001944_abnormal_pancreas_morphology0.78727361
113MP0002136_abnormal_kidney_physiology0.77690364
114MP0000613_abnormal_salivary_gland0.77342023
115MP0000462_abnormal_digestive_system0.76835931
116MP0005187_abnormal_penis_morphology0.76573975
117MP0002060_abnormal_skin_morphology0.76163355
118MP0009053_abnormal_anal_canal0.75890090
119MP0000604_amyloidosis0.73666954
120MP0000747_muscle_weakness0.72975905
121MP0002420_abnormal_adaptive_immunity0.72338716
122MP0001819_abnormal_immune_cell0.71816539
123MP0001661_extended_life_span0.70906544
124MP0010386_abnormal_urinary_bladder0.70823462
125MP0002075_abnormal_coat/hair_pigmentati0.70395184
126MP0004147_increased_porphyrin_level0.69968427
127MP0001186_pigmentation_phenotype0.69447864
128MP0002909_abnormal_adrenal_gland0.69334080
129MP0003795_abnormal_bone_structure0.68482785
130MP0001346_abnormal_lacrimal_gland0.66538338
131MP0001873_stomach_inflammation0.66493758
132MP0002089_abnormal_postnatal_growth/wei0.66378112
133MP0003638_abnormal_response/metabolism_0.65903932
134MP0005408_hypopigmentation0.65790952
135MP0005334_abnormal_fat_pad0.65354854
136MP0003448_altered_tumor_morphology0.65152898
137MP0005376_homeostasis/metabolism_phenot0.64026507
138MP0005451_abnormal_body_composition0.63869073
139MP0003936_abnormal_reproductive_system0.62879751
140MP0003329_amyloid_beta_deposits0.61439130
141MP0010368_abnormal_lymphatic_system0.61060485
142MP0005535_abnormal_body_temperature0.60942219
143MP0004036_abnormal_muscle_relaxation0.60853138
144MP0001919_abnormal_reproductive_system0.60825321
145MP0005257_abnormal_intraocular_pressure0.60822636
146MP0008874_decreased_physiological_sensi0.60562666
147MP0002127_abnormal_cardiovascular_syste0.60059382
148MP0003186_abnormal_redox_activity0.59056304
149MP0005647_abnormal_sex_gland0.58848346
150MP0009765_abnormal_xenobiotic_induced0.58808207
151MP0005330_cardiomyopathy0.56480289
152MP0000230_abnormal_systemic_arterial0.56053759
153MP0005164_abnormal_response_to0.55890635
154MP0002896_abnormal_bone_mineralization0.54525322
155MP0009384_cardiac_valve_regurgitation0.54140246
156MP0003953_abnormal_hormone_level0.53984881
157MP0009763_increased_sensitivity_to0.51564609
158MP0009780_abnormal_chondrocyte_physiolo0.50653294
159MP0005166_decreased_susceptibility_to0.50256356
160MP0000371_diluted_coat_color0.49577182
161MP0002009_preneoplasia0.48618924
162MP0002135_abnormal_kidney_morphology0.47642733
163MP0002796_impaired_skin_barrier0.46812484
164MP0003942_abnormal_urinary_system0.46752948
165MP0005670_abnormal_white_adipose0.44627223
166MP0004947_skin_inflammation0.44061179

Predicted human phenotypes

RankGene SetZ-score
1Shawl scrotum (HP:0000049)6.38194786
2Increased cerebral lipofuscin (HP:0011813)6.33231815
3Deep venous thrombosis (HP:0002625)5.76263147
4Intrahepatic cholestasis (HP:0001406)5.44598467
5Disinhibition (HP:0000734)5.31474907
6Prolonged partial thromboplastin time (HP:0003645)5.18155967
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.04080300
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.99970557
9Loss of speech (HP:0002371)4.96372746
10Malnutrition (HP:0004395)4.93492108
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.88901751
12Neurofibrillary tangles (HP:0002185)4.44906023
13Xanthomatosis (HP:0000991)4.40852558
14Hypobetalipoproteinemia (HP:0003563)4.40338697
15Dysostosis multiplex (HP:0000943)4.34819454
16Abnormality of the axillary hair (HP:0100134)4.33609591
17Abnormality of secondary sexual hair (HP:0009888)4.33609591
18Complement deficiency (HP:0004431)4.14755970
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.14599732
20Abnormality of the intrinsic pathway (HP:0010989)4.13106790
21Long toe (HP:0010511)4.08459269
22Ileus (HP:0002595)4.05886377
23Abnormality of macrophages (HP:0004311)4.03760853
24Apathy (HP:0000741)3.96710660
25Diminished motivation (HP:0000745)3.92748657
26Axonal loss (HP:0003447)3.83443695
27Abnormality of the common coagulation pathway (HP:0010990)3.82306317
28Hyperlipoproteinemia (HP:0010980)3.72159632
29Prostate neoplasm (HP:0100787)3.69096834
30Fat malabsorption (HP:0002630)3.68333178
31Joint hemorrhage (HP:0005261)3.67360328
32Agnosia (HP:0010524)3.59110279
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.55855198
34Abnormality of polysaccharide metabolism (HP:0011012)3.55855198
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.55855198
36Ketosis (HP:0001946)3.55055203
37Cerebral inclusion bodies (HP:0100314)3.52070248
38Aortic aneurysm (HP:0004942)3.51140239
39Abnormal gallbladder physiology (HP:0012438)3.47873096
40Cholecystitis (HP:0001082)3.47873096
41Hyperglycinemia (HP:0002154)3.46914176
42Hyperammonemia (HP:0001987)3.45552636
43Multiple enchondromatosis (HP:0005701)3.43800289
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.43234045
45Aplastic anemia (HP:0001915)3.41602480
46Urinary glycosaminoglycan excretion (HP:0003541)3.40031806
47Mucopolysacchariduria (HP:0008155)3.40031806
48Aplasia of the musculature (HP:0100854)3.37161966
49Inappropriate behavior (HP:0000719)3.22070504
50Hypolipoproteinemia (HP:0010981)3.17804239
51Abnormality of glycine metabolism (HP:0010895)3.17251437
52Abnormality of serine family amino acid metabolism (HP:0010894)3.17251437
53Abnormality of the periventricular white matter (HP:0002518)3.15198707
54Steatorrhea (HP:0002570)3.10919346
55Camptodactyly of toe (HP:0001836)3.09912648
56Mutism (HP:0002300)3.08118307
57Hyperglycinuria (HP:0003108)3.03312176
58Autoimmune thrombocytopenia (HP:0001973)3.02513122
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.01401935
60Poor head control (HP:0002421)2.98416202
61Epidermoid cyst (HP:0200040)2.92565640
62Myopathic facies (HP:0002058)2.89284982
63Abnormality of complement system (HP:0005339)2.88617012
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87938800
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86481611
66Sparse lateral eyebrow (HP:0005338)2.84731720
67Abnormality of purine metabolism (HP:0004352)2.78138605
68Neuronal loss in central nervous system (HP:0002529)2.76201776
69Hyperventilation (HP:0002883)2.76032109
70Abnormality of fatty-acid metabolism (HP:0004359)2.73829645
71Abnormality of nucleobase metabolism (HP:0010932)2.73706794
72Hypoalphalipoproteinemia (HP:0003233)2.73696211
73Cholelithiasis (HP:0001081)2.73219517
74Recurrent bacterial skin infections (HP:0005406)2.71576327
75Agitation (HP:0000713)2.70860181
76Abnormal gallbladder morphology (HP:0012437)2.67369276
77Spastic diplegia (HP:0001264)2.66838016
78Gastrointestinal dysmotility (HP:0002579)2.65636459
79Abnormality of pyrimidine metabolism (HP:0004353)2.64843171
80Hypoplastic nipples (HP:0002557)2.63653259
81Sensorimotor neuropathy (HP:0007141)2.62652204
82Metaphyseal irregularity (HP:0003025)2.62246874
83Midline defect of the nose (HP:0004122)2.61495111
84Upper motor neuron abnormality (HP:0002127)2.61309201
85Recurrent abscess formation (HP:0002722)2.60817381
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.60253788
87Eczematoid dermatitis (HP:0000976)2.59322592
88Prolonged neonatal jaundice (HP:0006579)2.58993467
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56402316
90Conjugated hyperbilirubinemia (HP:0002908)2.55513965
91Paralysis (HP:0003470)2.53418212
92Abnormality of methionine metabolism (HP:0010901)2.51732054
93Hypoglycemic coma (HP:0001325)2.51113777
94Blepharitis (HP:0000498)2.49632390
95Spontaneous abortion (HP:0005268)2.49421295
96Aortic dissection (HP:0002647)2.49059736
97Dementia (HP:0000726)2.48386119
98Vacuolated lymphocytes (HP:0001922)2.45288243
99Stroke (HP:0001297)2.44496328
100Potter facies (HP:0002009)2.44254452
101Facial shape deformation (HP:0011334)2.44254452
102Cardiomegaly (HP:0001640)2.42535039
103Ketoacidosis (HP:0001993)2.42531230
104Menorrhagia (HP:0000132)2.40981638
105Infantile muscular hypotonia (HP:0008947)2.38624298
106Pancreatitis (HP:0001733)2.35868427
107Hypercholesterolemia (HP:0003124)2.34213292
108Pathologic fracture (HP:0002756)2.33156283
109Delayed CNS myelination (HP:0002188)2.32106666
110Asymmetric septal hypertrophy (HP:0001670)2.32069813
111Hyperbilirubinemia (HP:0002904)2.30363036
112Breast hypoplasia (HP:0003187)2.30189041
113Nuclear cataract (HP:0100018)2.29957909
114Personality changes (HP:0000751)2.29318529
115Purpura (HP:0000979)2.23808736
116Protuberant abdomen (HP:0001538)2.23361072
117Joint contractures involving the joints of the feet (HP:0100492)2.20186919
118Flexion contracture of toe (HP:0005830)2.20186919
119Progressive neurologic deterioration (HP:0002344)2.17973150
120Esophageal varix (HP:0002040)2.17855348
121Recurrent gram-negative bacterial infections (HP:0005420)2.16992549
122Aplasia/Hypoplasia involving the musculature (HP:0001460)2.16059007
123Anal stenosis (HP:0002025)2.16017502
124Thoracic kyphosis (HP:0002942)2.16007111
125Hepatosplenomegaly (HP:0001433)2.14786471
126Hepatocellular carcinoma (HP:0001402)2.14494650
127Supranuclear gaze palsy (HP:0000605)2.13262878
128Right ventricular cardiomyopathy (HP:0011663)2.12255513
129Hemiplegia (HP:0002301)2.11668664
130Absent hand (HP:0004050)2.10974366
131J-shaped sella turcica (HP:0002680)2.09130732
132Global brain atrophy (HP:0002283)2.07490638
133Nausea (HP:0002018)2.06668155
134Dysphonia (HP:0001618)2.06347089
135Vascular calcification (HP:0004934)2.05768939
136Amyloidosis (HP:0011034)2.04898354
137Peripheral demyelination (HP:0011096)2.04298750
138Increased CSF protein (HP:0002922)2.03279942
139Cortical dysplasia (HP:0002539)2.01748740
140Gout (HP:0001997)2.01658216
141Abnormality of serum amino acid levels (HP:0003112)2.01197710
142Aplasia/Hypoplasia of the scapulae (HP:0006713)2.00459176
143Hypoplastic scapulae (HP:0000882)2.00459176
144Abnormality of glycolipid metabolism (HP:0010969)11.0284538
145Abnormality of liposaccharide metabolism (HP:0010968)11.0284538
146Abnormality of glycosphingolipid metabolism (HP:0004343)11.0284538
147Myocardial infarction (HP:0001658)1.98355217
148Aneurysm (HP:0002617)1.97272531
149Testicular atrophy (HP:0000029)1.95785346
150Abnormality of the prostate (HP:0008775)1.95730893
151Skin nodule (HP:0200036)1.95682212
152Abnormality of the gallbladder (HP:0005264)1.93467200
153Systemic lupus erythematosus (HP:0002725)1.91396603
154Status epilepticus (HP:0002133)1.91390204
155Abnormality of the Achilles tendon (HP:0005109)1.91329217
156Ectopia lentis (HP:0001083)1.91175851
157Multiple lipomas (HP:0001012)1.90383955
158Acanthocytosis (HP:0001927)1.88767422
159Abnormality of the lumbar spine (HP:0100712)1.88615714
160Irregular vertebral endplates (HP:0003301)1.88203273
161Esophageal neoplasm (HP:0100751)1.86887826
162Neoplasm of head and neck (HP:0012288)1.86887826
163Retinal atrophy (HP:0001105)1.84574256
164Generalized aminoaciduria (HP:0002909)1.83899996
165Fetal akinesia sequence (HP:0001989)1.83074078
166Mediastinal lymphadenopathy (HP:0100721)1.82732805
167Bone pain (HP:0002653)1.78093601
168Petechiae (HP:0000967)1.75655473
169Clumsiness (HP:0002312)1.68395984
170Azoospermia (HP:0000027)1.68317875
171Ragged-red muscle fibers (HP:0003200)1.66463671
172Albinism (HP:0001022)1.62743992
173Polyphagia (HP:0002591)1.58884878
174Increased serum ferritin (HP:0003281)1.58868914
175Oligomenorrhea (HP:0000876)1.58391710
176Abnormality of the odontoid process (HP:0003310)1.55903328
177Myoclonus (HP:0001336)1.54234127
178Abnormal cartilage morphology (HP:0002763)1.54218518
179Basal ganglia calcification (HP:0002135)1.53917648
180Abnormal neuron morphology (HP:0012757)1.52815495
181Abnormality of the motor neurons (HP:0002450)1.52815495
182Fasciculations (HP:0002380)1.52753982
183Hypoplasia of the odontoid process (HP:0003311)1.52540707
184Abnormality of the vertebral endplates (HP:0005106)1.51645083
185Abnormality of the vasculature of the conjunctiva (HP:0008054)1.51311941
186Hypokinesia (HP:0002375)1.50025616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.30774864
2BCKDK4.20397943
3PRKD33.26255838
4MYLK3.23382967
5DYRK33.12470607
6PDK22.91486167
7EEF2K2.72116076
8TAOK12.55221449
9ERN12.49310181
10CAMKK22.33619035
11PIK3CG2.20474361
12SIK12.15600386
13GRK72.15170767
14PIM22.06878911
15LATS12.05834862
16AKT310.3247153
17TNK21.89688107
18BLK1.88285667
19RIPK41.87682533
20TESK21.86563049
21ACVR1B1.86153953
22FRK1.75939493
23NEK91.69085128
24PTK61.67251330
25PRKD21.66456734
26NME21.66067397
27MAP2K71.62259345
28TRIB31.56755292
29ARAF1.56180090
30MAPKAPK31.46260959
31TTN1.45612366
32MAP3K21.45123436
33LIMK11.43724023
34MAP3K141.32289179
35TYK21.23793269
36PAK21.23328087
37PKN21.21312304
38GRK11.20081715
39MAP3K111.14035869
40SGK21.13565499
41MAP3K30.98353778
42STK390.95579501
43PIK3CA0.95307154
44MST1R0.94323792
45CSF1R0.89938594
46MAPK120.89706631
47CAMK1G0.88351114
48INSRR0.88266307
49FGR0.88106500
50ADRBK20.86725540
51FGFR40.84763215
52JAK20.83851851
53MAP3K10.83640461
54BMX0.83250538
55TAOK20.81732982
56DMPK0.81589453
57MAP3K130.80381318
58CSK0.78521895
59EIF2AK30.78196480
60RPS6KB20.77567546
61TESK10.76803888
62MAPK130.75667836
63TRPM70.71233571
64ICK0.70056313
65PDGFRA0.68437181
66IRAK30.66884201
67RIPK10.66387588
68MAP3K50.66130573
69SGK2230.65145134
70SGK4940.65145134
71CSNK1A1L0.65103941
72MAP2K40.64251244
73LRRK20.64176123
74MARK20.62539960
75NEK60.61481367
76MAP3K60.59274584
77MET0.58588791
78RPS6KB10.58435498
79PTK20.57998801
80CAMK1D0.57112408
81MOS0.55144941
82FER0.54829523
83MAP2K60.54512532
84MAP3K70.54408689
85PDPK10.53764147
86ERBB20.51614752
87RAF10.51394307
88JAK10.50336037
89PRKCZ0.50051799
90STK100.50005502
91MTOR0.49277365
92MAPK110.48962832
93PAK30.48489611
94CDC42BPA0.48136914
95FLT30.47375935
96NEK10.47179867
97GRK60.46762614
98TGFBR20.45621695
99LMTK20.43890047
100EPHB10.42273910
101RPS6KC10.40699617
102RPS6KL10.40699617
103MAPK70.39366227
104BRAF0.39208126
105CSNK1G30.38754115
106RET0.38639552
107EGFR0.37973446
108LYN0.37753571
109CAMK2G0.37747743
110MAP3K80.37584222
111GSK3A0.37545348
112LATS20.36871636
113CSNK1G20.36777346
114JAK30.36604863
115PDK10.36384744
116PDK40.34481019
117PDK30.34481019
118CAMK40.34441097
119DDR20.33540366
120IKBKB0.33435350
121FYN0.32306461
122RPS6KA20.31731063
123MAPKAPK50.31716223
124ZAP700.30943414
125RPS6KA60.30299995
126MAP2K10.30169653
127MARK10.28744180
128CSNK1A10.27774541
129ABL10.26963927
130TBK10.24752415
131NUAK10.24744101
132MARK30.23874752
133DYRK1B0.23333365
134ERBB40.22073079
135PRKAA20.21922731
136STK30.21136411
137MAP2K20.21009888
138ROCK10.20849207
139SCYL20.19849044
140FGFR20.18950562
141INSR0.18308265
142MAPK40.18097725
143MST40.17944202
144CAMK10.17459362
145ABL20.16763698
146PRKCH0.16705750
147NTRK10.15877831
148OXSR10.15510663
149PRKACB0.14988478
150MAP2K30.13205332
151MAP3K40.13118378
152PRKD10.12581965
153PDGFRB0.12326146
154SGK30.12009130
155DAPK20.11367552
156EPHA20.10610478
157IGF1R0.09964942
158IRAK20.09865671
159CAMKK10.09822099
160SRC0.08732235

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.57691690
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.98498590
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.91553263
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.78398770
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25598185
6Arginine biosynthesis_Homo sapiens_hsa002203.06115758
7Collecting duct acid secretion_Homo sapiens_hsa049663.05983843
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93068680
9Sulfur metabolism_Homo sapiens_hsa009202.88261333
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.81516076
11Rheumatoid arthritis_Homo sapiens_hsa053232.76336710
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74550423
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.73586649
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40520713
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39356053
16Phagosome_Homo sapiens_hsa041452.30780371
17Complement and coagulation cascades_Homo sapiens_hsa046102.29887111
18Vibrio cholerae infection_Homo sapiens_hsa051102.29722045
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29437586
20Tryptophan metabolism_Homo sapiens_hsa003802.26429093
21Fatty acid degradation_Homo sapiens_hsa000712.22509924
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.20042820
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01039879
24Tuberculosis_Homo sapiens_hsa051521.85088045
25Butanoate metabolism_Homo sapiens_hsa006501.81964115
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81918866
27Osteoclast differentiation_Homo sapiens_hsa043801.80968564
28Propanoate metabolism_Homo sapiens_hsa006401.78756412
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77949739
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68180568
31Peroxisome_Homo sapiens_hsa041461.62630065
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.61762303
33PPAR signaling pathway_Homo sapiens_hsa033201.60651806
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.53739307
35Bile secretion_Homo sapiens_hsa049761.53726724
36Histidine metabolism_Homo sapiens_hsa003401.53610753
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.51200798
38beta-Alanine metabolism_Homo sapiens_hsa004101.50882287
39Chemical carcinogenesis_Homo sapiens_hsa052041.49948799
40Renin-angiotensin system_Homo sapiens_hsa046141.48497222
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47903995
42Fatty acid metabolism_Homo sapiens_hsa012121.43577733
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42656277
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42242877
45Asthma_Homo sapiens_hsa053101.41744351
46Synaptic vesicle cycle_Homo sapiens_hsa047211.40165208
47Sphingolipid metabolism_Homo sapiens_hsa006001.37219346
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34311452
49Selenocompound metabolism_Homo sapiens_hsa004501.27087212
50Staphylococcus aureus infection_Homo sapiens_hsa051501.26261495
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.22290332
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.18844092
53Caffeine metabolism_Homo sapiens_hsa002321.16220576
54Pyruvate metabolism_Homo sapiens_hsa006201.16114565
55Phenylalanine metabolism_Homo sapiens_hsa003601.14910488
56Leishmaniasis_Homo sapiens_hsa051401.13271155
57Retinol metabolism_Homo sapiens_hsa008301.12368840
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08884757
59Biosynthesis of amino acids_Homo sapiens_hsa012301.08116735
60Antigen processing and presentation_Homo sapiens_hsa046121.05929036
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04318642
62ABC transporters_Homo sapiens_hsa020100.99048302
63Tyrosine metabolism_Homo sapiens_hsa003500.96590941
64Allograft rejection_Homo sapiens_hsa053300.92561111
65Lysine degradation_Homo sapiens_hsa003100.90489548
66Starch and sucrose metabolism_Homo sapiens_hsa005000.88622432
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87975690
68Vitamin B6 metabolism_Homo sapiens_hsa007500.87343075
69Legionellosis_Homo sapiens_hsa051340.85328489
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.84715741
71Fatty acid elongation_Homo sapiens_hsa000620.84633403
72Carbon metabolism_Homo sapiens_hsa012000.84163281
73Arginine and proline metabolism_Homo sapiens_hsa003300.82632282
74Fat digestion and absorption_Homo sapiens_hsa049750.80009519
75Autoimmune thyroid disease_Homo sapiens_hsa053200.77478145
76Folate biosynthesis_Homo sapiens_hsa007900.77312818
77N-Glycan biosynthesis_Homo sapiens_hsa005100.76417743
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76009519
79Ether lipid metabolism_Homo sapiens_hsa005650.75618883
80Notch signaling pathway_Homo sapiens_hsa043300.73535903
81Pertussis_Homo sapiens_hsa051330.72400911
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69120396
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69115687
84Salmonella infection_Homo sapiens_hsa051320.68525064
85Protein export_Homo sapiens_hsa030600.67056509
86Galactose metabolism_Homo sapiens_hsa000520.66341484
87Graft-versus-host disease_Homo sapiens_hsa053320.66048918
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.65482357
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65385989
90Toxoplasmosis_Homo sapiens_hsa051450.64823424
91TNF signaling pathway_Homo sapiens_hsa046680.64261947
92B cell receptor signaling pathway_Homo sapiens_hsa046620.60362602
93Regulation of autophagy_Homo sapiens_hsa041400.59038610
94Glutathione metabolism_Homo sapiens_hsa004800.58442167
95Viral myocarditis_Homo sapiens_hsa054160.58312932
96Type I diabetes mellitus_Homo sapiens_hsa049400.57036582
97Hepatitis C_Homo sapiens_hsa051600.56235673
98Malaria_Homo sapiens_hsa051440.56134808
99Insulin resistance_Homo sapiens_hsa049310.51920358
100Sulfur relay system_Homo sapiens_hsa041220.51869562
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51821436
102Chemokine signaling pathway_Homo sapiens_hsa040620.49314228
103Hematopoietic cell lineage_Homo sapiens_hsa046400.46804927
104Apoptosis_Homo sapiens_hsa042100.46770469
105Estrogen signaling pathway_Homo sapiens_hsa049150.44450940
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43461376
107Vitamin digestion and absorption_Homo sapiens_hsa049770.41721353
108Glycerolipid metabolism_Homo sapiens_hsa005610.41664974
109Prion diseases_Homo sapiens_hsa050200.39923560
110Influenza A_Homo sapiens_hsa051640.39706844
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38150256
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.38014224
113Endocytosis_Homo sapiens_hsa041440.37410720
114One carbon pool by folate_Homo sapiens_hsa006700.37198848
115Fructose and mannose metabolism_Homo sapiens_hsa000510.35454075
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35422888
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.32961907
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32185995
119Steroid biosynthesis_Homo sapiens_hsa001000.32069727
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.31737139
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30620643
122mTOR signaling pathway_Homo sapiens_hsa041500.29578323
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29421020
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28611121
125Other glycan degradation_Homo sapiens_hsa005110.28016704
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27824768
127Metabolic pathways_Homo sapiens_hsa011000.25086544
128Renin secretion_Homo sapiens_hsa049240.25020371
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25009516
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21757522
131Prolactin signaling pathway_Homo sapiens_hsa049170.20949767
132AMPK signaling pathway_Homo sapiens_hsa041520.19932224
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19468296
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19255799
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18832826
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.18680572
137Thyroid hormone synthesis_Homo sapiens_hsa049180.18441089
138Fatty acid biosynthesis_Homo sapiens_hsa000610.17825244
139Glucagon signaling pathway_Homo sapiens_hsa049220.17326363
140Mineral absorption_Homo sapiens_hsa049780.14237940
141Insulin signaling pathway_Homo sapiens_hsa049100.12936393
142Pentose phosphate pathway_Homo sapiens_hsa000300.11254352
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10082150
144Salivary secretion_Homo sapiens_hsa049700.07490055
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04326669
146Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03628825
147Ovarian steroidogenesis_Homo sapiens_hsa049130.03494044
148Gastric acid secretion_Homo sapiens_hsa049710.02435255
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.01132342
150* Lysosome_Homo sapiens_hsa041420.00727181
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00547027
152Acute myeloid leukemia_Homo sapiens_hsa052210.00455402
153Amoebiasis_Homo sapiens_hsa05146-0.0321369
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0292881
155Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0278915
156Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0200086
157Tight junction_Homo sapiens_hsa04530-0.0064193

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