DND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)6.38429331
2synapsis (GO:0007129)6.16084524
3base-excision repair, AP site formation (GO:0006285)5.03411169
4meiosis I (GO:0007127)4.99475748
5behavioral response to nicotine (GO:0035095)4.95094802
6DNA replication initiation (GO:0006270)4.81714893
7formation of translation preinitiation complex (GO:0001731)4.78958640
8DNA unwinding involved in DNA replication (GO:0006268)4.73335136
9DNA strand elongation involved in DNA replication (GO:0006271)4.72692622
10chromosome organization involved in meiosis (GO:0070192)4.60175476
11maturation of SSU-rRNA (GO:0030490)4.55850109
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.54807690
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.54807690
14NADH dehydrogenase complex assembly (GO:0010257)4.54807690
15DNA strand elongation (GO:0022616)4.44908438
16pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.43042069
17ncRNA 3-end processing (GO:0043628)4.38892862
18DNA replication-dependent nucleosome organization (GO:0034723)4.36570739
19DNA replication-dependent nucleosome assembly (GO:0006335)4.36570739
20oogenesis (GO:0048477)4.36190538
21male meiosis (GO:0007140)4.34064108
22telomere maintenance via semi-conservative replication (GO:0032201)4.31193851
23DNA replication checkpoint (GO:0000076)4.30639589
24female gamete generation (GO:0007292)4.28933224
25protein complex biogenesis (GO:0070271)4.20531950
26mitotic metaphase plate congression (GO:0007080)4.18411878
27protein localization to kinetochore (GO:0034501)4.06334908
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.99655757
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.99655757
30ribosome biogenesis (GO:0042254)3.95759773
31mitochondrial respiratory chain complex assembly (GO:0033108)3.94341234
32histone arginine methylation (GO:0034969)3.93271164
33mitotic nuclear envelope disassembly (GO:0007077)3.92714045
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.89711936
35positive regulation of meiosis (GO:0045836)3.81877129
36protein-cofactor linkage (GO:0018065)3.80202462
37piRNA metabolic process (GO:0034587)3.78905894
38* regulation of gene silencing by RNA (GO:0060966)3.78856744
39* regulation of posttranscriptional gene silencing (GO:0060147)3.78856744
40* regulation of gene silencing by miRNA (GO:0060964)3.78856744
41chromatin remodeling at centromere (GO:0031055)3.76600935
42proteasome assembly (GO:0043248)3.76578612
43ribonucleoprotein complex biogenesis (GO:0022613)3.76261033
44metaphase plate congression (GO:0051310)3.75686803
45telomere maintenance via recombination (GO:0000722)3.73667128
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70894049
47telomere maintenance via telomere lengthening (GO:0010833)3.69654872
48nuclear pore organization (GO:0006999)3.68947315
49pyrimidine nucleotide catabolic process (GO:0006244)3.67749127
50nodal signaling pathway (GO:0038092)3.67369425
51membrane disassembly (GO:0030397)3.66042198
52nuclear envelope disassembly (GO:0051081)3.66042198
53regulation of helicase activity (GO:0051095)3.63562040
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59825989
55positive regulation of meiotic cell cycle (GO:0051446)3.59738653
56ribosomal large subunit biogenesis (GO:0042273)3.59346359
57DNA methylation involved in gamete generation (GO:0043046)3.58029056
58nucleobase biosynthetic process (GO:0046112)3.56878780
59regulation of meiosis I (GO:0060631)3.56304935
60mitotic recombination (GO:0006312)3.56170420
61CENP-A containing nucleosome assembly (GO:0034080)3.55655201
62resolution of meiotic recombination intermediates (GO:0000712)3.55414925
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.54048526
64spliceosomal snRNP assembly (GO:0000387)3.53341739
65negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.50570882
66galactose catabolic process (GO:0019388)3.50017339
67ribosomal small subunit assembly (GO:0000028)3.49652755
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.49042525
69ribosomal small subunit biogenesis (GO:0042274)3.49003478
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.48045482
71mitotic chromosome condensation (GO:0007076)3.46170829
72DNA replication-independent nucleosome organization (GO:0034724)3.45276477
73DNA replication-independent nucleosome assembly (GO:0006336)3.45276477
74folic acid-containing compound biosynthetic process (GO:0009396)3.44684059
75pseudouridine synthesis (GO:0001522)3.42562854
76viral transcription (GO:0019083)3.41649679
77protein localization to chromosome, centromeric region (GO:0071459)3.41059360
78translational termination (GO:0006415)3.40724215
79peptidyl-arginine omega-N-methylation (GO:0035247)3.39844858
80IMP biosynthetic process (GO:0006188)3.37916548
81nuclear pore complex assembly (GO:0051292)3.34847563
82rRNA processing (GO:0006364)3.34193027
83protein K6-linked ubiquitination (GO:0085020)3.34087350
84heterochromatin organization (GO:0070828)3.33960854
85axoneme assembly (GO:0035082)3.28770048
86kinetochore organization (GO:0051383)3.28661504
87meiotic cell cycle process (GO:1903046)3.28146234
88establishment of integrated proviral latency (GO:0075713)3.27335112
89negative regulation of chromosome segregation (GO:0051985)3.27282996
90cotranslational protein targeting to membrane (GO:0006613)3.26998962
91deoxyribonucleotide catabolic process (GO:0009264)3.25831680
92meiotic chromosome segregation (GO:0045132)3.25422103
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25081472
94kinetochore assembly (GO:0051382)3.24970092
95translational initiation (GO:0006413)3.24499151
96rRNA metabolic process (GO:0016072)3.23314196
97histone H4-K12 acetylation (GO:0043983)3.22833207
98attachment of spindle microtubules to kinetochore (GO:0008608)3.22699424
99synaptonemal complex assembly (GO:0007130)3.21884008
100protein targeting to ER (GO:0045047)3.20917602
101viral life cycle (GO:0019058)3.20432680
102DNA duplex unwinding (GO:0032508)3.20132667
103ribosome assembly (GO:0042255)3.19917674
104respiratory electron transport chain (GO:0022904)3.19314947
105DNA geometric change (GO:0032392)3.18841338
106mitotic spindle checkpoint (GO:0071174)3.18665538
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17722939
108negative regulation of sister chromatid segregation (GO:0033046)3.17722939
109negative regulation of mitotic sister chromatid separation (GO:2000816)3.17722939
110negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17722939
111ubiquinone metabolic process (GO:0006743)3.17337576
112chaperone-mediated protein transport (GO:0072321)3.16183535
113negative regulation of meiosis (GO:0045835)3.15866976
114translational elongation (GO:0006414)3.15438853
115rRNA methylation (GO:0031167)3.15348259
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15043216
117electron transport chain (GO:0022900)3.14929382
118spindle checkpoint (GO:0031577)3.14587396
119deoxyribose phosphate catabolic process (GO:0046386)3.14029851
120purine nucleobase biosynthetic process (GO:0009113)3.14011922
121mitotic spindle assembly checkpoint (GO:0007094)3.13816624
122transcription-coupled nucleotide-excision repair (GO:0006283)3.13508838
123spindle assembly checkpoint (GO:0071173)3.13143837
124establishment of chromosome localization (GO:0051303)3.12754290
125positive regulation of mitochondrial fission (GO:0090141)3.12475845
126mismatch repair (GO:0006298)3.11825201
127rRNA modification (GO:0000154)3.11602516
128histone exchange (GO:0043486)3.10754285
129pyrimidine nucleobase catabolic process (GO:0006208)3.10422438
130cellular protein complex disassembly (GO:0043624)3.10051127
131spliceosomal complex assembly (GO:0000245)3.08928117
132regulation of mitochondrial translation (GO:0070129)3.08806430
133DNA deamination (GO:0045006)3.07461918
134establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07449407
135negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06939215
136histone H2A acetylation (GO:0043968)3.05325210
137negative regulation of DNA-templated transcription, elongation (GO:0032785)3.04960944
138protein localization to endoplasmic reticulum (GO:0070972)3.04355986
139DNA catabolic process, exonucleolytic (GO:0000738)3.04252977
140ubiquinone biosynthetic process (GO:0006744)3.03952108
141mitotic sister chromatid segregation (GO:0000070)3.03264688
142meiotic nuclear division (GO:0007126)3.02939595
143nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97383345
144IMP metabolic process (GO:0046040)2.96704837
145ATP synthesis coupled proton transport (GO:0015986)2.95562268
146energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95562268
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.93863005
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.93863005
149chromatin assembly or disassembly (GO:0006333)2.93313345
150postreplication repair (GO:0006301)2.92177278
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.90846639
152termination of RNA polymerase III transcription (GO:0006386)2.90846639
153synaptonemal complex organization (GO:0070193)2.90539568
154cullin deneddylation (GO:0010388)2.88919923
155sequestering of actin monomers (GO:0042989)2.85207210
156epithelial cilium movement (GO:0003351)2.76776289
157pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73468970
158meiotic cell cycle (GO:0051321)2.72431712
159reciprocal DNA recombination (GO:0035825)2.71398763
160reciprocal meiotic recombination (GO:0007131)2.71398763
161DNA synthesis involved in DNA repair (GO:0000731)2.71276228
162protein complex disassembly (GO:0043241)2.69615330
163single strand break repair (GO:0000012)2.68547780
164spermatid development (GO:0007286)2.68333773
165gene silencing by RNA (GO:0031047)2.63781402
166substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.63628778
167substrate-independent telencephalic tangential migration (GO:0021826)2.63628778
168platelet dense granule organization (GO:0060155)2.63370282
169macromolecular complex disassembly (GO:0032984)2.62414382
170intraciliary transport (GO:0042073)2.61908741
171cellular component biogenesis (GO:0044085)2.59527011
172synaptic transmission, cholinergic (GO:0007271)2.57882843
173water-soluble vitamin biosynthetic process (GO:0042364)2.56708300
174purine deoxyribonucleotide catabolic process (GO:0009155)2.54707165
175histone H3-K9 methylation (GO:0051567)2.53787030
176gonadal mesoderm development (GO:0007506)2.52914219
177cilium movement (GO:0003341)2.52844925
178seminiferous tubule development (GO:0072520)2.50671090
179DNA methylation (GO:0006306)2.49899159
180DNA alkylation (GO:0006305)2.49899159
181* germ cell development (GO:0007281)2.48650660
182positive regulation of gastrulation (GO:2000543)2.48159156
183regulation of penile erection (GO:0060405)2.45115527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.46453744
2EZH2_22144423_ChIP-Seq_EOC_Human5.91789682
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.49883397
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51419671
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.38659674
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37994050
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19960613
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94296693
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88803548
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77985105
11IGF1R_20145208_ChIP-Seq_DFB_Human2.74885129
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72578854
13ZNF274_21170338_ChIP-Seq_K562_Hela2.69478250
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.66846321
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.62088401
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62068028
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48339651
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46587313
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44074934
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41305516
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.39905594
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39846940
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36044872
24VDR_22108803_ChIP-Seq_LS180_Human2.35734682
25XRN2_22483619_ChIP-Seq_HELA_Human2.32250639
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.30753657
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.30753657
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.30753657
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20813947
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.11082277
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06578844
32VDR_23849224_ChIP-Seq_CD4+_Human2.06390887
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03238408
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02693251
35NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01417043
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01274908
37AR_21909140_ChIP-Seq_LNCAP_Human1.97104681
38DCP1A_22483619_ChIP-Seq_HELA_Human1.94653332
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.88039411
40TTF2_22483619_ChIP-Seq_HELA_Human1.85680544
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85333133
42RNF2_27304074_Chip-Seq_NSC_Mouse1.84379956
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84173267
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82612952
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79902326
46GABP_19822575_ChIP-Seq_HepG2_Human1.78200302
47FOXP3_21729870_ChIP-Seq_TREG_Human1.77806955
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68073782
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.66241781
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.65949441
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.65942079
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65280452
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.63877120
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59070390
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55442335
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54113210
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54034975
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52762086
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51474381
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50907021
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50381244
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48860064
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.47707846
64CIITA_25753668_ChIP-Seq_RAJI_Human1.46251040
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45625328
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43701497
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43438263
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.43294698
69REST_21632747_ChIP-Seq_MESCs_Mouse1.42742558
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42466934
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42109259
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41697308
73MYC_22102868_ChIP-Seq_BL_Human1.39034659
74TP53_22573176_ChIP-Seq_HFKS_Human1.37638265
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.37210241
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36994744
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36490777
78EWS_26573619_Chip-Seq_HEK293_Human1.35919395
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.35254181
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35007354
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34435061
82KDM5A_27292631_Chip-Seq_BREAST_Human1.33991163
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31699673
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30504484
85IRF1_19129219_ChIP-ChIP_H3396_Human1.30472762
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.30043881
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28576838
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26985135
89* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.26267610
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26266809
91TFEB_21752829_ChIP-Seq_HELA_Human1.25747669
92TP63_19390658_ChIP-ChIP_HaCaT_Human1.25100900
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23319755
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23237904
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22938855
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21029137
97JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20419180
98ERA_21632823_ChIP-Seq_H3396_Human1.19972672
99ELK1_19687146_ChIP-ChIP_HELA_Human1.18618193
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17803300
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.16217477
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15194068
103FUS_26573619_Chip-Seq_HEK293_Human1.14371628
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13916232
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13878687
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13176155
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12979585
108JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12301804
109MYC_19829295_ChIP-Seq_ESCs_Human1.11468304
110* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11183680
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10008174
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.09816837
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09816837
114* YY1_22570637_ChIP-Seq_MALME-3M_Human1.09720093
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07539020
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06823855
117MYC_18940864_ChIP-ChIP_HL60_Human1.06012267
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05242568
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05208133
120* FOXH1_21741376_ChIP-Seq_EPCs_Human1.05094245
121* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04880283
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04807376
123ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04013013
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03952651
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03853411
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02679526
127RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01405331
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01034697
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00149176
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99718880
131NANOG_20526341_ChIP-Seq_ESCs_Human0.99101162
132TAF15_26573619_Chip-Seq_HEK293_Human0.98335310
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98248388
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97486649
135NANOG_21062744_ChIP-ChIP_HESCs_Human0.96935958
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96871081
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96588115
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96222444
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96131174
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.95088567
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.94624451
142GATA3_21878914_ChIP-Seq_MCF-7_Human0.94103077
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93908780
144OCT4_19829295_ChIP-Seq_ESCs_Human0.93326329
145ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92991394
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92066919
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92061565
148RNF2_27304074_Chip-Seq_ESCs_Mouse0.91695092
149* BCL6_27268052_Chip-Seq_Bcells_Human0.90036570
150OCT4_20526341_ChIP-Seq_ESCs_Human0.89390935
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89293381
152TAF2_19829295_ChIP-Seq_ESCs_Human0.89142916
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88896108
154* FOXP1_21924763_ChIP-Seq_HESCs_Human0.88837665
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88372165
156CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88102647
157FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87851220
158AR_20517297_ChIP-Seq_VCAP_Human0.86598540
159* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86489903
160* PHF8_20622854_ChIP-Seq_HELA_Human0.82764466
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82472837
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.82282318
163CTCF_20526341_ChIP-Seq_ESCs_Human0.82042577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.65789839
2MP0008057_abnormal_DNA_replication4.58030380
3MP0004957_abnormal_blastocyst_morpholog4.50237699
4MP0003111_abnormal_nucleus_morphology4.33692451
5MP0003693_abnormal_embryo_hatching4.29852828
6MP0008877_abnormal_DNA_methylation4.17643319
7MP0008058_abnormal_DNA_repair4.02088835
8MP0003077_abnormal_cell_cycle3.77917503
9MP0003123_paternal_imprinting3.17538588
10MP0008007_abnormal_cellular_replicative2.96782282
11MP0003786_premature_aging2.81576027
12MP0004133_heterotaxia2.75809593
13MP0010352_gastrointestinal_tract_polyps2.61263822
14MP0008932_abnormal_embryonic_tissue2.59155587
15MP0003787_abnormal_imprinting2.58098598
16MP0001730_embryonic_growth_arrest2.35843725
17MP0004043_abnormal_pH_regulation2.32445420
18MP0000350_abnormal_cell_proliferation2.24225200
19MP0006276_abnormal_autonomic_nervous2.12619484
20MP0004885_abnormal_endolymph2.09855107
21MP0006072_abnormal_retinal_apoptosis2.07861733
22MP0001984_abnormal_olfaction2.02790857
23MP0005645_abnormal_hypothalamus_physiol1.92823427
24MP0003890_abnormal_embryonic-extraembry1.90879312
25* MP0002210_abnormal_sex_determination1.90587672
26MP0001764_abnormal_homeostasis1.85687121
27MP0003806_abnormal_nucleotide_metabolis1.82481211
28MP0008995_early_reproductive_senescence1.80684770
29MP0004147_increased_porphyrin_level1.80198978
30MP0005380_embryogenesis_phenotype1.77799504
31MP0001672_abnormal_embryogenesis/_devel1.77799504
32MP0004142_abnormal_muscle_tone1.74728299
33MP0001697_abnormal_embryo_size1.74283152
34MP0002837_dystrophic_cardiac_calcinosis1.73128263
35MP0002396_abnormal_hematopoietic_system1.72463515
36MP0010386_abnormal_urinary_bladder1.72165656
37MP0003880_abnormal_central_pattern1.69741795
38MP0010307_abnormal_tumor_latency1.68833218
39MP0003941_abnormal_skin_development1.68048930
40* MP0001145_abnormal_male_reproductive1.66614072
41MP0005174_abnormal_tail_pigmentation1.65308845
42MP0005499_abnormal_olfactory_system1.64058307
43MP0005394_taste/olfaction_phenotype1.64058307
44MP0005423_abnormal_somatic_nervous1.61845410
45MP0003122_maternal_imprinting1.61129298
46MP0004197_abnormal_fetal_growth/weight/1.57673032
47MP0002085_abnormal_embryonic_tissue1.57312773
48* MP0001929_abnormal_gametogenesis1.57260632
49MP0002084_abnormal_developmental_patter1.56875795
50MP0002080_prenatal_lethality1.55434171
51MP0002928_abnormal_bile_duct1.54743947
52MP0003984_embryonic_growth_retardation1.53011457
53MP0001905_abnormal_dopamine_level1.51543207
54MP0010030_abnormal_orbit_morphology1.51065876
55MP0000490_abnormal_crypts_of1.50935636
56MP0002088_abnormal_embryonic_growth/wei1.49970831
57MP0003718_maternal_effect1.49578282
58MP0005551_abnormal_eye_electrophysiolog1.48825901
59MP0000313_abnormal_cell_death1.48249552
60MP0002272_abnormal_nervous_system1.47986513
61MP0003283_abnormal_digestive_organ1.47684579
62MP0000631_abnormal_neuroendocrine_gland1.47101338
63MP0001986_abnormal_taste_sensitivity1.46753878
64MP0002095_abnormal_skin_pigmentation1.45360476
65MP0003121_genomic_imprinting1.44868144
66MP0002138_abnormal_hepatobiliary_system1.41817547
67MP0009745_abnormal_behavioral_response1.41778174
68* MP0000653_abnormal_sex_gland1.38746406
69* MP0002019_abnormal_tumor_incidence1.38378897
70MP0002086_abnormal_extraembryonic_tissu1.35795442
71MP0005084_abnormal_gallbladder_morpholo1.34214460
72MP0002638_abnormal_pupillary_reflex1.34172911
73MP0002234_abnormal_pharynx_morphology1.32728092
74MP0000015_abnormal_ear_pigmentation1.32176178
75MP0006292_abnormal_olfactory_placode1.31639239
76MP0001919_abnormal_reproductive_system1.21176754
77MP0002277_abnormal_respiratory_mucosa1.19572631
78MP0001529_abnormal_vocalization1.16582363
79MP0005410_abnormal_fertilization1.16302766
80MP0003567_abnormal_fetal_cardiomyocyte1.15405185
81MP0002876_abnormal_thyroid_physiology1.12115525
82MP0009379_abnormal_foot_pigmentation1.09434590
83MP0002653_abnormal_ependyma_morphology1.09151290
84MP0003315_abnormal_perineum_morphology1.07053857
85MP0003119_abnormal_digestive_system1.04507460
86MP0002163_abnormal_gland_morphology1.04139169
87MP0005076_abnormal_cell_differentiation1.03486073
88MP0002160_abnormal_reproductive_system1.02825402
89MP0005253_abnormal_eye_physiology1.02489669
90MP0001293_anophthalmia1.01443135
91MP0002184_abnormal_innervation1.00468371
92MP0002736_abnormal_nociception_after1.00409114
93MP0002752_abnormal_somatic_nervous1.00102690
94* MP0001119_abnormal_female_reproductive0.99735916
95MP0003186_abnormal_redox_activity0.99507330
96MP0003221_abnormal_cardiomyocyte_apopto0.99151784
97MP0001968_abnormal_touch/_nociception0.99150102
98MP0000778_abnormal_nervous_system0.97500814
99MP0004808_abnormal_hematopoietic_stem0.97452371
100* MP0003698_abnormal_male_reproductive0.95865167
101MP0005646_abnormal_pituitary_gland0.95595398
102MP0002734_abnormal_mechanical_nocicepti0.95397954
103MP0005670_abnormal_white_adipose0.94267978
104MP0005397_hematopoietic_system_phenotyp0.93241453
105MP0001545_abnormal_hematopoietic_system0.93241453
106MP0002139_abnormal_hepatobiliary_system0.92627300
107MP0000538_abnormal_urinary_bladder0.91940057
108MP0002572_abnormal_emotion/affect_behav0.91744250
109MP0000026_abnormal_inner_ear0.90614188
110MP0001188_hyperpigmentation0.90305188
111MP0003136_yellow_coat_color0.90108217
112MP0003635_abnormal_synaptic_transmissio0.89431055
113MP0002557_abnormal_social/conspecific_i0.88664839
114MP0000703_abnormal_thymus_morphology0.87251331
115MP0000566_synostosis0.86843863
116MP0005195_abnormal_posterior_eye0.86574552
117MP0001324_abnormal_eye_pigmentation0.86298229
118MP0002067_abnormal_sensory_capabilities0.85595437
119MP0002111_abnormal_tail_morphology0.84928105
120MP0000358_abnormal_cell_content/0.84318983
121MP0003763_abnormal_thymus_physiology0.84282179
122MP0002882_abnormal_neuron_morphology0.83596310
123MP0005501_abnormal_skin_physiology0.83380809
124MP0002233_abnormal_nose_morphology0.82125836
125MP0006036_abnormal_mitochondrial_physio0.80808880
126MP0002229_neurodegeneration0.80343397
127MP0000427_abnormal_hair_cycle0.79365073
128MP0002822_catalepsy0.79074585
129MP0005266_abnormal_metabolism0.78841324
130MP0000372_irregular_coat_pigmentation0.78700421
131MP0002063_abnormal_learning/memory/cond0.78699571
132MP0009333_abnormal_splenocyte_physiolog0.78463648
133MP0009672_abnormal_birth_weight0.78355817
134MP0001486_abnormal_startle_reflex0.77085746
135MP0002733_abnormal_thermal_nociception0.76736196
136MP0001970_abnormal_pain_threshold0.76643485
137MP0000955_abnormal_spinal_cord0.76136329
138MP0002735_abnormal_chemical_nociception0.75771554
139MP0005384_cellular_phenotype0.74829332
140MP0000689_abnormal_spleen_morphology0.74615577
141MP0002722_abnormal_immune_system0.73040045
142* MP0002161_abnormal_fertility/fecundity0.72283706
143MP0005389_reproductive_system_phenotype0.71754286
144MP0009278_abnormal_bone_marrow0.71196921
145MP0005621_abnormal_cell_physiology0.70690810
146MP0002132_abnormal_respiratory_system0.70301899
147MP0003936_abnormal_reproductive_system0.69438820
148MP0006035_abnormal_mitochondrial_morpho0.69386157
149MP0000858_altered_metastatic_potential0.67113785
150MP0002398_abnormal_bone_marrow0.65682854
151MP0001915_intracranial_hemorrhage0.64261580
152MP0002075_abnormal_coat/hair_pigmentati0.62662330
153MP0002127_abnormal_cardiovascular_syste0.61281287
154MP0000537_abnormal_urethra_morphology0.59211172
155MP0003646_muscle_fatigue0.57441397
156MP0001853_heart_inflammation0.57130855
157MP0002254_reproductive_system_inflammat0.56770800
158MP0005075_abnormal_melanosome_morpholog0.56664938
159MP0003699_abnormal_female_reproductive0.55807248
160MP0002249_abnormal_larynx_morphology0.55235729
161MP0001286_abnormal_eye_development0.54552335
162MP0000049_abnormal_middle_ear0.52794712
163MP0000432_abnormal_head_morphology0.51687696
164MP0003861_abnormal_nervous_system0.50871832
165MP0008789_abnormal_olfactory_epithelium0.48168993
166MP0002429_abnormal_blood_cell0.47844028
167MP0009703_decreased_birth_body0.47352195
168MP0000477_abnormal_intestine_morphology0.47327524

Predicted human phenotypes

RankGene SetZ-score
1Nonprogressive disorder (HP:0003680)6.12877809
2Birth length less than 3rd percentile (HP:0003561)4.81042685
3Ependymoma (HP:0002888)4.44510547
4Reticulocytopenia (HP:0001896)4.28500096
5Chronic hepatic failure (HP:0100626)4.13593006
6Colon cancer (HP:0003003)3.99188092
7Acute necrotizing encephalopathy (HP:0006965)3.92899854
8Breast hypoplasia (HP:0003187)3.90452877
9Chromsome breakage (HP:0040012)3.90249727
10Carpal bone hypoplasia (HP:0001498)3.81756637
11Medulloblastoma (HP:0002885)3.80069113
12Abnormal mitochondria in muscle tissue (HP:0008316)3.78934904
13Hyperglycinemia (HP:0002154)3.74836546
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60156477
15Agnosia (HP:0010524)3.57156843
16Hepatocellular necrosis (HP:0001404)3.40171359
17Mitochondrial inheritance (HP:0001427)3.34127084
18Degeneration of anterior horn cells (HP:0002398)3.33909964
19Abnormality of the anterior horn cell (HP:0006802)3.33909964
20Acute encephalopathy (HP:0006846)3.32662688
21Absent thumb (HP:0009777)3.29852344
22Supernumerary spleens (HP:0009799)3.28199951
23Hepatic necrosis (HP:0002605)3.28114878
24Selective tooth agenesis (HP:0001592)3.25670982
25Abnormality of the labia minora (HP:0012880)3.23036851
26Patellar aplasia (HP:0006443)3.19977699
27Rhabdomyosarcoma (HP:0002859)3.19898966
28Increased CSF lactate (HP:0002490)3.16616231
29Abdominal situs inversus (HP:0003363)3.16382307
30Abnormality of abdominal situs (HP:0011620)3.16382307
31Progressive macrocephaly (HP:0004481)3.15505108
32Cerebral hypomyelination (HP:0006808)3.11491681
33Abnormality of cells of the erythroid lineage (HP:0012130)3.08373484
34Absent radius (HP:0003974)3.07554391
35Adenoma sebaceum (HP:0009720)3.05455676
36Angiofibromas (HP:0010615)3.05455676
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.00254386
38Abnormal number of erythroid precursors (HP:0012131)2.98393437
393-Methylglutaconic aciduria (HP:0003535)2.97667628
40Abnormality of the preputium (HP:0100587)2.93472965
4111 pairs of ribs (HP:0000878)2.90449655
42Aplasia/Hypoplasia of the patella (HP:0006498)2.89370341
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87404019
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87404019
45Aplasia involving forearm bones (HP:0009822)2.86576495
46Absent forearm bone (HP:0003953)2.86576495
47Nephronophthisis (HP:0000090)2.82468415
48Oral leukoplakia (HP:0002745)2.82167360
49Abnormality of chromosome stability (HP:0003220)2.81480044
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.80501255
51Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80501255
52Congenital stationary night blindness (HP:0007642)2.77538619
53Abnormality of the astrocytes (HP:0100707)2.76542339
54Astrocytoma (HP:0009592)2.76542339
55Meckel diverticulum (HP:0002245)2.74962770
56Impulsivity (HP:0100710)2.71997948
57Abnormality of midbrain morphology (HP:0002418)2.71596339
58Molar tooth sign on MRI (HP:0002419)2.71596339
59Abnormality of DNA repair (HP:0003254)2.70984785
60Horseshoe kidney (HP:0000085)2.66226855
61Rough bone trabeculation (HP:0100670)2.65050270
62Premature ovarian failure (HP:0008209)2.64467561
63Basal cell carcinoma (HP:0002671)2.64132123
64Abnormality of the ileum (HP:0001549)2.63269737
65Neoplasm of striated muscle (HP:0009728)2.59783279
66Limb dystonia (HP:0002451)2.58719695
67Cerebral edema (HP:0002181)2.57669828
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.56395969
69Missing ribs (HP:0000921)2.56388579
70Neoplasm of the pancreas (HP:0002894)2.55898346
71Rib fusion (HP:0000902)2.50931397
72Neoplasm of the oral cavity (HP:0100649)2.50401756
73Pancreatic cysts (HP:0001737)2.49854275
74Trismus (HP:0000211)2.48809413
75Asplenia (HP:0001746)2.47187248
76Oligodactyly (hands) (HP:0001180)2.45471928
77Methylmalonic acidemia (HP:0002912)2.44849361
78Abnormality of pyrimidine metabolism (HP:0004353)2.43615863
79Atrophy/Degeneration involving motor neurons (HP:0007373)2.42165313
80Proximal placement of thumb (HP:0009623)2.40520799
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.38575610
82Osteomalacia (HP:0002749)2.38092342
83Medial flaring of the eyebrow (HP:0010747)2.36886724
84Hypergonadotropic hypogonadism (HP:0000815)2.35734473
85Macrocytic anemia (HP:0001972)2.35250784
86Hydroureter (HP:0000072)2.34919628
87Abnormal lung lobation (HP:0002101)2.34719710
88Abnormality of the renal medulla (HP:0100957)2.33583512
89Retinal dysplasia (HP:0007973)2.31939146
90Duodenal stenosis (HP:0100867)2.31913834
91Small intestinal stenosis (HP:0012848)2.31913834
92Lipid accumulation in hepatocytes (HP:0006561)2.30884683
93Glioma (HP:0009733)2.30602198
94Facial hemangioma (HP:0000329)2.30070340
95Abnormality of glycine metabolism (HP:0010895)2.29993732
96Abnormality of serine family amino acid metabolism (HP:0010894)2.29993732
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29944313
98Pancreatic fibrosis (HP:0100732)2.27202480
99Myelodysplasia (HP:0002863)2.27062348
100Pallor (HP:0000980)2.25464330
101Exercise intolerance (HP:0003546)2.24685134
102Hyperglycinuria (HP:0003108)2.23452257
103Lactic acidosis (HP:0003128)2.22804959
104Deviation of the thumb (HP:0009603)2.22058116
105Microvesicular hepatic steatosis (HP:0001414)2.21232220
106Duplicated collecting system (HP:0000081)2.20115126
107Increased serum lactate (HP:0002151)2.19983234
108Abnormality of the corticospinal tract (HP:0002492)2.19408251
109Multiple enchondromatosis (HP:0005701)2.19186193
110Secondary amenorrhea (HP:0000869)2.18477693
111Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17163798
112Dicarboxylic aciduria (HP:0003215)2.17163798
113Squamous cell carcinoma (HP:0002860)2.16113407
114Aplasia/hypoplasia of the humerus (HP:0006507)2.15884175
115Biliary tract neoplasm (HP:0100574)2.15635487
116Sparse eyelashes (HP:0000653)2.15270978
117Increased hepatocellular lipid droplets (HP:0006565)2.13708290
118Shawl scrotum (HP:0000049)2.12387792
119Increased intramyocellular lipid droplets (HP:0012240)2.12202249
120Neoplasm of the colon (HP:0100273)2.12158135
121Myokymia (HP:0002411)2.11284383
122Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10640139
123Aplastic anemia (HP:0001915)2.08814282
124Abnormal number of incisors (HP:0011064)2.08691393
125Abnormal ciliary motility (HP:0012262)2.08199457
126Rectovaginal fistula (HP:0000143)2.07457080
127Rectal fistula (HP:0100590)2.07457080
128Concave nail (HP:0001598)2.07304313
129Premature graying of hair (HP:0002216)2.06702043
130Tracheoesophageal fistula (HP:0002575)2.06658670
131Spinal muscular atrophy (HP:0007269)2.03936486
132Irregular epiphyses (HP:0010582)2.03479084
133Methylmalonic aciduria (HP:0012120)2.03115390
134Increased muscle lipid content (HP:0009058)2.01631688
135Polyphagia (HP:0002591)2.01599099
136Azoospermia (HP:0000027)2.00368083
137Abnormal spermatogenesis (HP:0008669)1.99987967
138Tongue fasciculations (HP:0001308)1.99884592
139Triphalangeal thumb (HP:0001199)1.99836911
140Progressive muscle weakness (HP:0003323)1.99060096
141Metaphyseal cupping (HP:0003021)1.98564819
142Ectopic kidney (HP:0000086)1.98289461
143Atresia of the external auditory canal (HP:0000413)1.97946109
144Abnormality of the duodenum (HP:0002246)1.97820769
145Abnormality of urine glucose concentration (HP:0011016)1.97504908
146Glycosuria (HP:0003076)1.97504908
147Thyroid-stimulating hormone excess (HP:0002925)1.96967100
148Bone marrow hypocellularity (HP:0005528)1.96344314
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96091093
150Abnormal respiratory motile cilium physiology (HP:0012261)1.95993429
151CNS hypomyelination (HP:0003429)1.95123157
152Amaurosis fugax (HP:0100576)1.95116538
153Sloping forehead (HP:0000340)1.93587710
154Pancytopenia (HP:0001876)1.93383014
155Chronic sinusitis (HP:0011109)1.90208356
156Gait imbalance (HP:0002141)1.89441348
157High anterior hairline (HP:0009890)1.88909234
158Renal Fanconi syndrome (HP:0001994)1.88806161
159Metabolic acidosis (HP:0001942)1.88728846
160Cleft eyelid (HP:0000625)1.87905259
161Disproportionate short-trunk short stature (HP:0003521)1.87276071
162Abnormal sex determination (HP:0012244)1.87186257
163Sex reversal (HP:0012245)1.87186257
164Delayed CNS myelination (HP:0002188)1.85964884
165Volvulus (HP:0002580)1.85038773
166Tubulointerstitial nephritis (HP:0001970)1.84787560
167Type I transferrin isoform profile (HP:0003642)1.84130580
168Pachygyria (HP:0001302)1.83762611
169Generalized aminoaciduria (HP:0002909)1.82940425
170Woolly hair (HP:0002224)1.82809553
171Abnormal respiratory motile cilium morphology (HP:0005938)1.82142200
172Abnormal respiratory epithelium morphology (HP:0012253)1.82142200
173Respiratory failure (HP:0002878)1.79724740
174Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76732045
175Nephrogenic diabetes insipidus (HP:0009806)1.72311017
176Congenital, generalized hypertrichosis (HP:0004540)1.71833165
177Lissencephaly (HP:0001339)1.71722133
178Occipital encephalocele (HP:0002085)1.71099831
179Poikiloderma (HP:0001029)1.69787410
180Anterior segment dysgenesis (HP:0007700)1.69108280
181Type 2 muscle fiber atrophy (HP:0003554)1.69072329
182Agammaglobulinemia (HP:0004432)1.68821669
183Spastic tetraplegia (HP:0002510)1.68091655
184Amyotrophic lateral sclerosis (HP:0007354)1.67353402
185Entropion (HP:0000621)1.67162356
186Optic disc pallor (HP:0000543)1.66099505
187Sclerocornea (HP:0000647)1.65572654
188Dysphonia (HP:0001618)1.65234051
189Brittle hair (HP:0002299)1.65074399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.38713884
2BUB14.85827049
3CDC74.55703566
4WEE14.01766271
5ACVR1B3.69833793
6GRK13.09464350
7EIF2AK12.82738245
8CDK122.80048988
9SRPK12.54624550
10TTK2.44037907
11PLK12.32162752
12PHKG22.27125367
13PHKG12.27125367
14CDK72.24000413
15PINK12.11225290
16NEK22.10992967
17TSSK62.09769785
18MARK12.07152038
19LMTK22.06166650
20NME21.95196929
21STK161.91984036
22MKNK11.84799079
23ATR1.82548396
24TLK11.81199101
25DYRK31.80362356
26MAP3K101.72007390
27CHEK21.64961390
28TAOK31.64201573
29MAP3K41.56861700
30CDK41.52659686
31MAPK131.52326309
32WNK31.51787534
33VRK11.50603198
34BRSK21.50564178
35TGFBR11.49978594
36MKNK21.47914939
37AURKB1.47116107
38AURKA1.46508017
39TESK21.43939201
40EIF2AK31.40861441
41STK101.40772804
42MAP2K71.40304959
43MST41.40099370
44CDK81.39762464
45CHEK11.39107739
46PASK1.38925800
47RPS6KB21.37174683
48WNK11.33243532
49PLK31.27670698
50EPHA21.26930403
51PLK41.23955391
52ABL21.22720347
53NTRK21.19395854
54TYRO31.15061436
55PBK1.13850394
56BMPR1B1.12729383
57CASK1.08331448
58MELK1.05484252
59ATM1.02923516
60OXSR11.01763783
61ALK1.01680530
62RPS6KA41.01602955
63CDK21.01375000
64CSNK1G20.99987360
65PIM10.99357389
66NEK10.99275835
67MAP3K80.95481665
68BRD40.95291826
69MAP3K30.94238060
70ADRBK20.92914996
71PAK40.92116174
72BCKDK0.91143639
73BRAF0.90149990
74ARAF0.89858423
75MAP4K10.89298660
76WNK40.89134214
77PLK20.89090938
78CSNK2A20.88232535
79MAP3K110.87567724
80STK40.86943129
81FRK0.84802855
82PRKD20.83719377
83MINK10.80149627
84CSNK1G30.78820981
85CSNK1G10.78714440
86NME10.77170162
87VRK20.76372198
88MAP2K40.74902593
89CSNK2A10.73154738
90STK38L0.71339276
91GRK60.70716244
92ICK0.69241081
93CDK10.68390329
94CDK11A0.66826577
95PAK10.65998809
96BRSK10.65465589
97PDK30.64894387
98PDK40.64894387
99STK390.64759186
100PRKCI0.63356267
101SIK20.62789596
102GRK70.62248204
103MAP4K20.62091026
104MARK20.61925752
105MARK30.60378496
106DYRK1A0.59077973
107STK110.57626870
108UHMK10.57002523
109CAMK1G0.56457481
110PRKCG0.56390045
111EIF2AK20.56015850
112CCNB10.55054344
113PNCK0.54957830
114DAPK10.53860666
115SGK2230.53570583
116SGK4940.53570583
117STK240.52954011
118CSNK1E0.52116820
119CDK140.50616825
120ADRBK10.49981167
121PRKACA0.49545453
122PRKDC0.48994042
123BCR0.48480656
124CDK50.46680234
125MAPK110.46388530
126CAMK10.44719341
127RPS6KA60.44312738
128MAPKAPK30.43886339
129KDR0.43795677
130ZAK0.43788902
131DYRK20.41868891
132PRKCZ0.40772604
133CDK60.40577143
134PRKG10.39072880
135MTOR0.38871315
136FLT30.38154024
137PDK20.37850885
138MAP3K60.37027130
139CSNK1A1L0.36000799
140PIM20.35296243
141RPS6KC10.35245218
142RPS6KL10.35245218
143MAP2K30.35071279
144PRKCE0.34041856
145MAPK150.33633782
146CDK150.33417351
147CDK90.33123778
148RPS6KA50.32359381
149CAMK2A0.32061785
150MAPK140.31940528
151KIT0.31332047
152MATK0.30166788
153SCYL20.30019102
154JAK30.29644789
155RPS6KA10.28185369
156AKT20.26508362
157GSK3B0.23167550
158TESK10.23082987
159MAPK10.22804348
160STK30.22727276
161IKBKB0.21298986
162PKN20.21023886
163RPS6KB10.20906682

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08441565
2Mismatch repair_Homo sapiens_hsa034304.77336985
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.14340744
4RNA polymerase_Homo sapiens_hsa030203.44564059
5Spliceosome_Homo sapiens_hsa030403.37479589
6Ribosome_Homo sapiens_hsa030103.33051324
7Homologous recombination_Homo sapiens_hsa034403.26592177
8RNA transport_Homo sapiens_hsa030133.21326205
9Base excision repair_Homo sapiens_hsa034103.14191437
10Proteasome_Homo sapiens_hsa030503.08116955
11Nucleotide excision repair_Homo sapiens_hsa034203.03232907
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91419304
13Cell cycle_Homo sapiens_hsa041102.73030344
14One carbon pool by folate_Homo sapiens_hsa006702.72141956
15Fanconi anemia pathway_Homo sapiens_hsa034602.44891006
16Basal transcription factors_Homo sapiens_hsa030222.42503989
17Non-homologous end-joining_Homo sapiens_hsa034502.38155128
18Pyrimidine metabolism_Homo sapiens_hsa002402.33394572
19Phototransduction_Homo sapiens_hsa047442.28401732
20Cardiac muscle contraction_Homo sapiens_hsa042601.94612864
21mRNA surveillance pathway_Homo sapiens_hsa030151.87414227
22Alzheimers disease_Homo sapiens_hsa050101.86072473
23RNA degradation_Homo sapiens_hsa030181.83697114
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75166480
25p53 signaling pathway_Homo sapiens_hsa041151.51806471
26Selenocompound metabolism_Homo sapiens_hsa004501.48747013
27Nicotine addiction_Homo sapiens_hsa050331.40395547
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34304717
29Caffeine metabolism_Homo sapiens_hsa002321.24627274
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21881501
31Collecting duct acid secretion_Homo sapiens_hsa049661.19062781
32Peroxisome_Homo sapiens_hsa041461.17236918
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15602694
34Purine metabolism_Homo sapiens_hsa002301.15439357
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12870338
36Steroid biosynthesis_Homo sapiens_hsa001001.12381704
37Epstein-Barr virus infection_Homo sapiens_hsa051691.11875880
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10614810
39Propanoate metabolism_Homo sapiens_hsa006401.09595151
40Oocyte meiosis_Homo sapiens_hsa041141.08809818
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04925833
42Folate biosynthesis_Homo sapiens_hsa007901.03708937
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.02532126
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96159828
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.94945635
46Fatty acid elongation_Homo sapiens_hsa000620.88622712
47Ether lipid metabolism_Homo sapiens_hsa005650.87162149
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85776825
49Biosynthesis of amino acids_Homo sapiens_hsa012300.85030389
50Taste transduction_Homo sapiens_hsa047420.84769371
51Herpes simplex infection_Homo sapiens_hsa051680.83246316
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82265029
53Retinol metabolism_Homo sapiens_hsa008300.80713486
54Huntingtons disease_Homo sapiens_hsa050160.75960187
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.74408346
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73262125
57TGF-beta signaling pathway_Homo sapiens_hsa043500.72496120
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72072355
59Viral carcinogenesis_Homo sapiens_hsa052030.71654995
60Morphine addiction_Homo sapiens_hsa050320.70824495
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70518595
62Synaptic vesicle cycle_Homo sapiens_hsa047210.68165821
63Olfactory transduction_Homo sapiens_hsa047400.67364722
64Sulfur relay system_Homo sapiens_hsa041220.66010759
65Butanoate metabolism_Homo sapiens_hsa006500.65605549
66HTLV-I infection_Homo sapiens_hsa051660.65189019
67Antigen processing and presentation_Homo sapiens_hsa046120.62962001
68Systemic lupus erythematosus_Homo sapiens_hsa053220.62646312
69Fatty acid degradation_Homo sapiens_hsa000710.60488744
70Thyroid cancer_Homo sapiens_hsa052160.58918488
71Parkinsons disease_Homo sapiens_hsa050120.57882630
72Ovarian steroidogenesis_Homo sapiens_hsa049130.55947904
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55811478
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54239571
75Glutathione metabolism_Homo sapiens_hsa004800.53313349
76Legionellosis_Homo sapiens_hsa051340.53030785
77beta-Alanine metabolism_Homo sapiens_hsa004100.52498926
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.50387114
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49945602
80Carbon metabolism_Homo sapiens_hsa012000.49037669
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48882171
82ABC transporters_Homo sapiens_hsa020100.47678325
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47553475
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.45753061
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45647916
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44984388
87Tryptophan metabolism_Homo sapiens_hsa003800.44578407
88Dopaminergic synapse_Homo sapiens_hsa047280.44171422
89MicroRNAs in cancer_Homo sapiens_hsa052060.44108501
90Dorso-ventral axis formation_Homo sapiens_hsa043200.43589723
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43455220
92Fatty acid metabolism_Homo sapiens_hsa012120.42028925
93Notch signaling pathway_Homo sapiens_hsa043300.41652478
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41491671
95Axon guidance_Homo sapiens_hsa043600.41113036
96Oxidative phosphorylation_Homo sapiens_hsa001900.40060058
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39928304
98GABAergic synapse_Homo sapiens_hsa047270.39564685
99Hippo signaling pathway_Homo sapiens_hsa043900.39359913
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38537339
101Colorectal cancer_Homo sapiens_hsa052100.37993892
102Basal cell carcinoma_Homo sapiens_hsa052170.37952033
103Chemical carcinogenesis_Homo sapiens_hsa052040.37595663
104Insulin secretion_Homo sapiens_hsa049110.37084007
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36633912
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.36285146
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35284355
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32834045
109Pentose phosphate pathway_Homo sapiens_hsa000300.32565850
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31685524
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31504247
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31327465
113Fructose and mannose metabolism_Homo sapiens_hsa000510.30554167
114Serotonergic synapse_Homo sapiens_hsa047260.28706364
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27998314
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27340940
117Primary immunodeficiency_Homo sapiens_hsa053400.27214111
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26511923
119Glutamatergic synapse_Homo sapiens_hsa047240.25109844
120HIF-1 signaling pathway_Homo sapiens_hsa040660.25079272
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24670904
122Apoptosis_Homo sapiens_hsa042100.24448352
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.23134183
124Metabolic pathways_Homo sapiens_hsa011000.21756020
125Galactose metabolism_Homo sapiens_hsa000520.18785778
126Lysine degradation_Homo sapiens_hsa003100.18458035
127Vitamin B6 metabolism_Homo sapiens_hsa007500.18193134
128Arachidonic acid metabolism_Homo sapiens_hsa005900.17962067
129Small cell lung cancer_Homo sapiens_hsa052220.16898575
130Protein export_Homo sapiens_hsa030600.16894531
131Linoleic acid metabolism_Homo sapiens_hsa005910.16703217
132Pathways in cancer_Homo sapiens_hsa052000.12983353
133Bladder cancer_Homo sapiens_hsa052190.12164074
134Acute myeloid leukemia_Homo sapiens_hsa052210.12080304
135Pyruvate metabolism_Homo sapiens_hsa006200.11842177
136Wnt signaling pathway_Homo sapiens_hsa043100.11765980
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11702117
138mTOR signaling pathway_Homo sapiens_hsa041500.11638414
139Hedgehog signaling pathway_Homo sapiens_hsa043400.10359641
140Arginine and proline metabolism_Homo sapiens_hsa003300.08966331
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08027312
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06916476
143Hepatitis B_Homo sapiens_hsa051610.06437308
144Adherens junction_Homo sapiens_hsa045200.06413047
145Measles_Homo sapiens_hsa051620.06039439
146Regulation of autophagy_Homo sapiens_hsa041400.04786306
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03976863
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.03873688
149Alcoholism_Homo sapiens_hsa050340.03489199
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03356162
151Influenza A_Homo sapiens_hsa051640.03286474
152Prostate cancer_Homo sapiens_hsa052150.02457321

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