DND1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine deoxyribonucleotide catabolic process (GO:0009155)7.12094456
2negative regulation of B cell apoptotic process (GO:0002903)6.85676858
3positive regulation of megakaryocyte differentiation (GO:0045654)5.54065076
4deoxyribonucleotide catabolic process (GO:0009264)5.34982934
5positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)5.32641219
6deoxyribose phosphate catabolic process (GO:0046386)4.97914840
7regulation of B cell apoptotic process (GO:0002902)4.83603686
8purine nucleotide salvage (GO:0032261)4.71428631
9negative regulation of phagocytosis (GO:0050765)4.66001907
10killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.58253553
11disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.58253553
12regulation of chemokine biosynthetic process (GO:0045073)4.54073939
13positive regulation of prostaglandin secretion (GO:0032308)4.36947196
14deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.33748292
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.30076370
16positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.30042088
17purine deoxyribonucleotide metabolic process (GO:0009151)4.24243822
18regulation of growth of symbiont in host (GO:0044126)4.15422804
19negative regulation of growth of symbiont in host (GO:0044130)4.15422804
20negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.15422804
21modulation of growth of symbiont involved in interaction with host (GO:0044144)4.15422804
22neutrophil mediated immunity (GO:0002446)4.02800161
23post-embryonic morphogenesis (GO:0009886)3.94756541
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92686057
25regulation of gene silencing by RNA (GO:0060966)3.88599264
26regulation of posttranscriptional gene silencing (GO:0060147)3.88599264
27regulation of gene silencing by miRNA (GO:0060964)3.88599264
28histone H3-K9 methylation (GO:0051567)3.86853181
29histone H3-K9 modification (GO:0061647)3.81883840
30nucleotide salvage (GO:0043173)3.80820474
31grooming behavior (GO:0007625)3.78552845
32base-excision repair, AP site formation (GO:0006285)3.75245229
33chaperone mediated protein folding requiring cofactor (GO:0051085)3.74832247
34snRNA processing (GO:0016180)3.69053731
35definitive hemopoiesis (GO:0060216)3.67349079
36regulation of prostaglandin secretion (GO:0032306)3.63984900
372-deoxyribonucleotide metabolic process (GO:0009394)3.63233344
38negative regulation of gene silencing (GO:0060969)3.58085175
39aggressive behavior (GO:0002118)3.53683893
40imidazole-containing compound metabolic process (GO:0052803)3.52727098
41snRNA metabolic process (GO:0016073)3.49806446
42pyrimidine nucleotide catabolic process (GO:0006244)3.46344286
43negative regulation of interleukin-8 production (GO:0032717)3.43707217
44cellular response to interferon-beta (GO:0035458)3.37167942
45DNA deamination (GO:0045006)3.34056745
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33808609
47deoxyribonucleotide metabolic process (GO:0009262)3.29945645
48deoxyribose phosphate metabolic process (GO:0019692)3.27247996
49positive regulation of antigen processing and presentation (GO:0002579)3.18333138
50negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17120554
51regulation of interleukin-8 biosynthetic process (GO:0045414)3.17051013
52deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.16168087
53positive regulation of granulocyte differentiation (GO:0030854)3.14720973
54Peyers patch development (GO:0048541)3.09386750
55mucosal-associated lymphoid tissue development (GO:0048537)3.09386750
56Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08262856
57purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.06826166
58regulation of megakaryocyte differentiation (GO:0045652)3.05996437
59negative regulation of lymphocyte apoptotic process (GO:0070229)3.00383465
60purine nucleobase biosynthetic process (GO:0009113)2.98545536
61positive regulation of B cell differentiation (GO:0045579)2.95518304
62negative regulation of chemokine production (GO:0032682)2.95289958
63mannosylation (GO:0097502)2.92224398
64estrogen biosynthetic process (GO:0006703)2.91238594
65cell morphogenesis involved in neuron differentiation (GO:0048667)2.91135624
66immunoglobulin mediated immune response (GO:0016064)2.89108480
67pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88143526
68DNA dealkylation (GO:0035510)2.87950349
69purine-containing compound salvage (GO:0043101)2.87852648
70mitochondrial DNA replication (GO:0006264)2.87605084
71mature B cell differentiation involved in immune response (GO:0002313)2.86202924
72cellular extravasation (GO:0045123)2.83193530
73myeloid leukocyte mediated immunity (GO:0002444)2.77573459
74DNA topological change (GO:0006265)2.75514599
75reactive oxygen species biosynthetic process (GO:1903409)2.74496916
76GDP-mannose metabolic process (GO:0019673)2.74195465
77negative regulation of mRNA processing (GO:0050686)2.73677486
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73291397
79regulation of penile erection (GO:0060405)2.72847245
80cellular response to exogenous dsRNA (GO:0071360)2.72516133
81regulation of translational fidelity (GO:0006450)2.72013806
82negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.71013992
83hyperosmotic salinity response (GO:0042538)2.70008173
84purine nucleoside diphosphate metabolic process (GO:0009135)2.69744119
85purine ribonucleoside diphosphate metabolic process (GO:0009179)2.69744119
86antigen processing and presentation of endogenous antigen (GO:0019883)2.68659917
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.67470633
88ribosomal small subunit assembly (GO:0000028)2.66855427
89prostanoid biosynthetic process (GO:0046457)2.65836261
90prostaglandin biosynthetic process (GO:0001516)2.65836261
91respiratory burst (GO:0045730)2.65794860
92positive regulation of receptor biosynthetic process (GO:0010870)2.65262301
93cell wall macromolecule catabolic process (GO:0016998)2.64877620
94blood vessel maturation (GO:0001955)2.63800247
95nucleobase biosynthetic process (GO:0046112)2.63774255
96nucleoside diphosphate catabolic process (GO:0009134)2.61333670
97regulation of antigen processing and presentation (GO:0002577)2.61245011
98positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.60983195
99DNA ligation (GO:0006266)2.60515453
100positive regulation of icosanoid secretion (GO:0032305)2.59977202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.92119813
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.81246319
3SCL_19346495_ChIP-Seq_HPC-7_Human2.78666935
4E2F7_22180533_ChIP-Seq_HELA_Human2.75687302
5MYC_22102868_ChIP-Seq_BL_Human2.69542624
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60116967
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46480036
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42061389
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31816172
10CIITA_25753668_ChIP-Seq_RAJI_Human2.28473332
11ELF1_20517297_ChIP-Seq_JURKAT_Human2.13878363
12VDR_24763502_ChIP-Seq_THP-1_Human2.13820796
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13095782
14TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10502995
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.03891405
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01544524
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00584858
18KDM5A_27292631_Chip-Seq_BREAST_Human1.98951826
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97280004
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96517201
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.91012561
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88278641
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.85065281
24GABP_19822575_ChIP-Seq_HepG2_Human1.84804249
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.82618691
26SPI1_23547873_ChIP-Seq_NB4_Human1.79534750
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77707836
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77413251
29LXR_22292898_ChIP-Seq_THP-1_Human1.75071913
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72398585
31UTX_26944678_Chip-Seq_JUKART_Human1.71731161
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71369581
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71128419
34BCL6_27268052_Chip-Seq_Bcells_Human1.70954834
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64562623
36FOXP3_21729870_ChIP-Seq_TREG_Human1.64191028
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63822851
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.60319426
39MAF_26560356_Chip-Seq_TH2_Human1.59547723
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.59174325
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58009396
42P68_20966046_ChIP-Seq_HELA_Human1.56252673
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53506487
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50441929
45VDR_23849224_ChIP-Seq_CD4+_Human1.50172190
46MYB_26560356_Chip-Seq_TH2_Human1.49894500
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49740974
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49304230
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.48130867
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46606290
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46249587
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44446506
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44198858
54PHF8_20622854_ChIP-Seq_HELA_Human1.42580614
55E2F1_20622854_ChIP-Seq_HELA_Human1.41422379
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.40444973
57BCOR_27268052_Chip-Seq_Bcells_Human1.39174424
58MAF_26560356_Chip-Seq_TH1_Human1.38894279
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37909384
60MYB_26560356_Chip-Seq_TH1_Human1.33041088
61CTCF_26484167_Chip-Seq_Bcells_Mouse1.32907453
62XRN2_22483619_ChIP-Seq_HELA_Human1.32476409
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32472070
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31104607
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30421228
66CTCF_21964334_Chip-Seq_Bcells_Human1.30223204
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.29007411
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28683550
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28506903
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28007888
71FOXP1_21924763_ChIP-Seq_HESCs_Human1.27690312
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26067185
73DCP1A_22483619_ChIP-Seq_HELA_Human1.25061232
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24385933
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23068011
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22420990
77P300_27268052_Chip-Seq_Bcells_Human1.21413875
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21164674
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21148293
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.20669527
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19669534
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19153142
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18102603
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17936042
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.17678183
86ZNF274_21170338_ChIP-Seq_K562_Hela1.17631494
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16409104
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16304969
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16122816
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16029047
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15423175
92CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12366373
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12203100
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.12139793
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11744844
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10919060
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09519907
98KDM2B_26808549_Chip-Seq_DND41_Human1.08823200
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07836073
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07809714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001545_abnormal_hematopoietic_system3.69567344
2MP0005397_hematopoietic_system_phenotyp3.69567344
3MP0009278_abnormal_bone_marrow3.50548044
4MP0000465_gastrointestinal_hemorrhage2.96431373
5MP0003172_abnormal_lysosome_physiology2.78984872
6MP0002396_abnormal_hematopoietic_system2.71586870
7MP0003806_abnormal_nucleotide_metabolis2.68486163
8MP0008058_abnormal_DNA_repair2.62201175
9MP0001764_abnormal_homeostasis2.53812849
10MP0001835_abnormal_antigen_presentation2.38490452
11MP0005387_immune_system_phenotype2.29877829
12MP0001790_abnormal_immune_system2.29877829
13MP0004808_abnormal_hematopoietic_stem2.16297923
14MP0005025_abnormal_response_to2.14563088
15MP0004043_abnormal_pH_regulation2.08998673
16MP0006292_abnormal_olfactory_placode2.08579206
17MP0004133_heterotaxia2.01236552
18MP0005464_abnormal_platelet_physiology1.96386088
19MP0008057_abnormal_DNA_replication1.89323825
20MP0002419_abnormal_innate_immunity1.78679137
21MP0001800_abnormal_humoral_immune1.78619654
22MP0010094_abnormal_chromosome_stability1.78410723
23MP0002148_abnormal_hypersensitivity_rea1.74520021
24MP0006072_abnormal_retinal_apoptosis1.69186689
25MP0004782_abnormal_surfactant_physiolog1.67555722
26MP0005075_abnormal_melanosome_morpholog1.66858648
27MP0003763_abnormal_thymus_physiology1.62120375
28MP0002398_abnormal_bone_marrow1.62038759
29MP0005645_abnormal_hypothalamus_physiol1.60841083
30MP0000689_abnormal_spleen_morphology1.59868578
31MP0002420_abnormal_adaptive_immunity1.59867608
32MP0001819_abnormal_immune_cell1.58967001
33MP0008007_abnormal_cellular_replicative1.57639941
34MP0005220_abnormal_exocrine_pancreas1.53498544
35MP0003436_decreased_susceptibility_to1.51031469
36MP0003866_abnormal_defecation1.48953152
37MP0004147_increased_porphyrin_level1.48732053
38MP0002723_abnormal_immune_serum1.47287769
39MP0008961_abnormal_basal_metabolism1.45946628
40MP0001873_stomach_inflammation1.45039589
41MP0002452_abnormal_antigen_presenting1.44864967
42MP0005671_abnormal_response_to1.43636540
43MP0004185_abnormal_adipocyte_glucose1.42240084
44MP0000681_abnormal_thyroid_gland1.41826189
45MP0000716_abnormal_immune_system1.41812246
46MP0002722_abnormal_immune_system1.41677876
47MP0009785_altered_susceptibility_to1.39911214
48MP0002019_abnormal_tumor_incidence1.39095097
49MP0005000_abnormal_immune_tolerance1.32536487
50MP0005646_abnormal_pituitary_gland1.32428321
51MP0002822_catalepsy1.31611947
52MP0002429_abnormal_blood_cell1.30540064
53MP0003786_premature_aging1.29515136
54MP0003787_abnormal_imprinting1.23855124
55MP0000685_abnormal_immune_system1.23582794
56MP0005670_abnormal_white_adipose1.23029021
57MP0002405_respiratory_system_inflammati1.22459181
58MP0008995_early_reproductive_senescence1.20910589
59MP0005310_abnormal_salivary_gland1.16961717
60MP0010386_abnormal_urinary_bladder1.16823629
61MP0002095_abnormal_skin_pigmentation1.16391380
62MP0006036_abnormal_mitochondrial_physio1.14134137
63MP0005084_abnormal_gallbladder_morpholo1.11305639
64MP0005501_abnormal_skin_physiology1.11080977
65MP0005367_renal/urinary_system_phenotyp1.08843204
66MP0000516_abnormal_urinary_system1.08843204
67MP0009764_decreased_sensitivity_to1.08418020
68MP0008469_abnormal_protein_level1.07743895
69MP0000490_abnormal_crypts_of1.05696492
70MP0003111_abnormal_nucleus_morphology1.05573723
71MP0003077_abnormal_cell_cycle1.04044279
72MP0005266_abnormal_metabolism1.04032355
73MP0003718_maternal_effect1.02897964
74MP0005376_homeostasis/metabolism_phenot1.00072509
75MP0000372_irregular_coat_pigmentation0.99375904
76MP0008873_increased_physiological_sensi0.97749140
77MP0005666_abnormal_adipose_tissue0.97077885
78MP0005410_abnormal_fertilization0.95309349
79MP0005647_abnormal_sex_gland0.93573056
80MP0002971_abnormal_brown_adipose0.92344043
81MP0005334_abnormal_fat_pad0.88615393
82MP0000015_abnormal_ear_pigmentation0.88134118
83MP0005076_abnormal_cell_differentiation0.86396656
84MP0001845_abnormal_inflammatory_respons0.83888774
85MP0002928_abnormal_bile_duct0.81588489
86MP0005319_abnormal_enzyme/_coenzyme0.80890658
87MP0000703_abnormal_thymus_morphology0.80724867
88MP0003943_abnormal_hepatobiliary_system0.80376502
89MP0001661_extended_life_span0.79781930
90MP0003656_abnormal_erythrocyte_physiolo0.79572537
91MP0005058_abnormal_lysosome_morphology0.75222068
92MP0009115_abnormal_fat_cell0.75169066
93MP0000598_abnormal_liver_morphology0.74621547
94MP0003693_abnormal_embryo_hatching0.73083716
95MP0004264_abnormal_extraembryonic_tissu0.72565161
96MP0008877_abnormal_DNA_methylation0.72319088
97MP0003385_abnormal_body_wall0.69546324
98MP0002970_abnormal_white_adipose0.66270359
99MP0009763_increased_sensitivity_to0.65222419
100MP0000858_altered_metastatic_potential0.62697612

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.97948579
2Thrombocytosis (HP:0001894)6.42583891
3Progressive external ophthalmoplegia (HP:0000590)5.23689258
4Elevated erythrocyte sedimentation rate (HP:0003565)4.91261831
5Cellulitis (HP:0100658)4.50237690
6Tubulointerstitial nephritis (HP:0001970)4.35998767
7Abnormality of the prostate (HP:0008775)4.20728560
8Congenital stationary night blindness (HP:0007642)3.52435497
9Microvesicular hepatic steatosis (HP:0001414)3.45016818
10Progressive muscle weakness (HP:0003323)3.40361694
11Obstructive lung disease (HP:0006536)3.29157526
12Chronic obstructive pulmonary disease (HP:0006510)3.29157526
13Glucose intolerance (HP:0000833)3.22788291
14Meningitis (HP:0001287)3.15751890
15Abnormality of B cell number (HP:0010975)3.11151917
16Neutropenia (HP:0001875)3.00182615
17Sepsis (HP:0100806)2.99782783
18Ureteral stenosis (HP:0000071)2.98980660
19Chromsome breakage (HP:0040012)2.98824314
20Eosinophilia (HP:0001880)2.98446114
21Reticulocytopenia (HP:0001896)2.96493564
22Granulocytopenia (HP:0001913)2.93044943
23Failure to thrive in infancy (HP:0001531)2.88825229
24Acute lymphatic leukemia (HP:0006721)2.88153593
25Hyperglycinemia (HP:0002154)2.84032083
26Hepatocellular necrosis (HP:0001404)2.83133957
27B lymphocytopenia (HP:0010976)2.80088555
28Ragged-red muscle fibers (HP:0003200)2.79325813
29Dicarboxylic aciduria (HP:0003215)2.76541138
30Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76541138
31Rhabdomyolysis (HP:0003201)2.75381162
32Type I transferrin isoform profile (HP:0003642)2.72251216
33Ureteral obstruction (HP:0006000)2.67488000
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67485691
35Abnormal protein glycosylation (HP:0012346)2.66058793
36Abnormal glycosylation (HP:0012345)2.66058793
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66058793
38Abnormal protein N-linked glycosylation (HP:0012347)2.66058793
39Chest pain (HP:0100749)2.64589709
40Abnormality of male internal genitalia (HP:0000022)2.63861904
41Leukocytosis (HP:0001974)2.61929261
42Thoracic kyphosis (HP:0002942)2.61751027
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.58903188
44Recurrent pneumonia (HP:0006532)2.57378286
45Abnormality of the thoracic spine (HP:0100711)2.56253170
46External ophthalmoplegia (HP:0000544)2.55204573
47Periodontitis (HP:0000704)2.54777992
48Skin rash (HP:0000988)2.54212966
49Autoimmune thrombocytopenia (HP:0001973)2.50894238
50Verrucae (HP:0200043)2.48857213
51Papilloma (HP:0012740)2.48857213
52Reduced antithrombin III activity (HP:0001976)2.47224024
53Duplication of thumb phalanx (HP:0009942)2.45061375
54Episodic fever (HP:0001954)2.41532825
55Hepatic necrosis (HP:0002605)2.40212387
56Chronic sinusitis (HP:0011109)2.40210443
57Prostate neoplasm (HP:0100787)2.40157159
58Cerebral palsy (HP:0100021)2.39300559
59Hypergonadotropic hypogonadism (HP:0000815)2.39249426
60Loss of speech (HP:0002371)2.39067603
61Increased cerebral lipofuscin (HP:0011813)2.37426893
62Panhypogammaglobulinemia (HP:0003139)2.37415464
63Myositis (HP:0100614)2.31933136
64Supernumerary spleens (HP:0009799)2.31695636
65Abnormality of the pleura (HP:0002103)2.27359190
66Hydroureter (HP:0000072)2.23507570
67Short tibia (HP:0005736)2.21926034
68Recurrent lower respiratory tract infections (HP:0002783)2.21392163
69Muscle stiffness (HP:0003552)2.21233572
70Abnormal delayed hypersensitivity skin test (HP:0002963)2.21132913
71Prolonged neonatal jaundice (HP:0006579)2.08854913
72Abnormality of eosinophils (HP:0001879)2.08393110
73Testicular atrophy (HP:0000029)2.05868549
74Volvulus (HP:0002580)2.04248089
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03545380
76Severe visual impairment (HP:0001141)2.03075728
77Dehydration (HP:0001944)1.99558426
78Progressive microcephaly (HP:0000253)1.99094935
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.98630722
80Persistence of primary teeth (HP:0006335)1.95759855
81Abnormal glucose tolerance (HP:0001952)1.94994088
82Recurrent viral infections (HP:0004429)1.91802581
83Hypoplasia of the pons (HP:0012110)1.89772437
84Abnormality of the proximal phalanges of the hand (HP:0009834)1.89769811
85Cerebellar dysplasia (HP:0007033)1.85836105
86Hypergammaglobulinemia (HP:0010702)1.85635017
87Impulsivity (HP:0100710)1.85050808
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82891865
89Asplenia (HP:0001746)1.81949944
90Thyroid-stimulating hormone excess (HP:0002925)1.80950515
91Villous atrophy (HP:0011473)1.80893992
92Abnormality of small intestinal villus morphology (HP:0011472)1.80893992
93Enlarged kidneys (HP:0000105)1.78889901
94Mediastinal lymphadenopathy (HP:0100721)1.76102357
95Emotional lability (HP:0000712)1.75501220
96Osteomyelitis (HP:0002754)1.73284467
97Large eyes (HP:0001090)1.73067425
98Petechiae (HP:0000967)1.71672516
99Vasculitis (HP:0002633)1.70568050
100Nephronophthisis (HP:0000090)1.70553171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK29.60548939
2ERN15.20259715
3TNK23.16088256
4PIM22.83597150
5BCKDK2.59476523
6KDR2.48542954
7ARAF2.43521661
8GRK12.35067683
9VRK22.34057509
10MAP4K22.33313847
11PBK2.19589613
12TRIM282.13864154
13MAP3K131.84509556
14SIK21.72787403
15SIK31.63402697
16PRKD21.63107234
17MAP4K11.46657772
18ZAK1.45000397
19CDK121.44743111
20KIT1.26651070
21SIK11.18941914
22CCNB11.10916959
23TAOK31.10189936
24FLT31.08748624
25CDK61.05190406
26TYK21.03067866
27MARK31.03065900
28CHEK20.97545274
29TAOK10.94793329
30MAP3K140.89664930
31SRPK10.89183851
32TBK10.85156894
33BRAF0.82942994
34CDC70.78483713
35PIK3CG0.78374459
36NME20.77130410
37MAP3K80.76849826
38CDK70.76820540
39IRAK30.76615515
40DYRK1B0.74448587
41ATR0.73505569
42TESK10.73238387
43GRK60.71967085
44SYK0.70981801
45NUAK10.70789271
46PRKCQ0.69837655
47MATK0.65429514
48MARK20.62747570
49IKBKB0.62688554
50BUB10.62527021
51ITK0.61451365
52CDK40.60747136
53JAK30.60608091
54BTK0.60353202
55CSF1R0.57683567
56DYRK30.57077072
57VRK10.56005888
58MAP3K110.54294724
59HIPK20.54262226
60DYRK20.53357650
61RPS6KL10.51174842
62RPS6KC10.51174842
63IKBKE0.48973240
64MAP2K30.48091209
65ICK0.46744765
66RPS6KA40.45607969
67LYN0.43696405
68RPS6KA60.40779598
69DAPK10.39719740
70MAPK110.39572711
71RAF10.38645831
72CDK90.38186773
73MAPKAPK30.37904435
74LCK0.37002954
75CAMK1D0.36697112
76PRKCI0.36602402
77MAP2K20.35512724
78RPS6KA50.34512027
79WNK40.32961487
80EIF2AK10.31781648
81PRKD10.30733055
82PIM10.30496122
83RPS6KB20.29716104
84WEE10.29401070
85STK100.28776912
86HCK0.28301758
87BRSK10.27800937
88AURKB0.27381094
89IRAK40.26820050
90PRKCH0.26316810
91CAMK1G0.25305872
92PLK10.23395563
93TAOK20.22677042
94LMTK20.22585287
95ABL20.22481939
96CHEK10.21870033
97CSNK2A10.21617884
98BRSK20.21212956
99CDK20.20975037
100CDK190.20830177

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.08866063
2Primary immunodeficiency_Homo sapiens_hsa053403.36540168
3Asthma_Homo sapiens_hsa053102.85161612
4Non-homologous end-joining_Homo sapiens_hsa034502.68777731
5Other glycan degradation_Homo sapiens_hsa005112.64429704
6DNA replication_Homo sapiens_hsa030302.64407605
7Fanconi anemia pathway_Homo sapiens_hsa034602.51061688
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.46066425
9Homologous recombination_Homo sapiens_hsa034402.41304602
10Sulfur relay system_Homo sapiens_hsa041222.33059710
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.28887543
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17621613
13Phototransduction_Homo sapiens_hsa047442.16339143
14Pyrimidine metabolism_Homo sapiens_hsa002402.11145186
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92449684
16Spliceosome_Homo sapiens_hsa030401.73601827
17Ribosome_Homo sapiens_hsa030101.73079959
18Fatty acid elongation_Homo sapiens_hsa000621.67205634
19Regulation of autophagy_Homo sapiens_hsa041401.60117763
20Mismatch repair_Homo sapiens_hsa034301.59560288
21N-Glycan biosynthesis_Homo sapiens_hsa005101.58836080
22Fatty acid metabolism_Homo sapiens_hsa012121.53271262
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.50206477
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46609395
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.44607121
26One carbon pool by folate_Homo sapiens_hsa006701.39246938
27Autoimmune thyroid disease_Homo sapiens_hsa053201.34083110
28B cell receptor signaling pathway_Homo sapiens_hsa046621.33172429
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.31832929
30Allograft rejection_Homo sapiens_hsa053301.30139927
31Antigen processing and presentation_Homo sapiens_hsa046121.28543990
32RNA polymerase_Homo sapiens_hsa030201.25676043
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25508223
34Herpes simplex infection_Homo sapiens_hsa051681.19734837
35Purine metabolism_Homo sapiens_hsa002301.17315669
36Peroxisome_Homo sapiens_hsa041461.13911051
37Renin-angiotensin system_Homo sapiens_hsa046141.13741878
38RNA degradation_Homo sapiens_hsa030181.09747041
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08978237
40Phenylalanine metabolism_Homo sapiens_hsa003601.03468265
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03051548
42Systemic lupus erythematosus_Homo sapiens_hsa053221.02581141
43Acute myeloid leukemia_Homo sapiens_hsa052211.01356851
44Steroid biosynthesis_Homo sapiens_hsa001001.00048907
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95334284
46Graft-versus-host disease_Homo sapiens_hsa053320.92176775
47Selenocompound metabolism_Homo sapiens_hsa004500.92166860
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89638232
49Hematopoietic cell lineage_Homo sapiens_hsa046400.88455199
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84918996
51Nucleotide excision repair_Homo sapiens_hsa034200.83750163
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.82228568
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81926082
54RNA transport_Homo sapiens_hsa030130.81624456
55Sulfur metabolism_Homo sapiens_hsa009200.76273078
56Carbon metabolism_Homo sapiens_hsa012000.75265695
57Glutathione metabolism_Homo sapiens_hsa004800.73072508
58mRNA surveillance pathway_Homo sapiens_hsa030150.72146403
59Hepatitis C_Homo sapiens_hsa051600.69262094
60Type I diabetes mellitus_Homo sapiens_hsa049400.68954051
61Lysine degradation_Homo sapiens_hsa003100.66047132
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.65167772
63Staphylococcus aureus infection_Homo sapiens_hsa051500.63196362
64Propanoate metabolism_Homo sapiens_hsa006400.60384481
65Cell cycle_Homo sapiens_hsa041100.59893265
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59664102
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58948611
68Lysosome_Homo sapiens_hsa041420.58869894
69Metabolic pathways_Homo sapiens_hsa011000.58600729
70Histidine metabolism_Homo sapiens_hsa003400.57255298
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56901156
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55400604
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52636155
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.51764911
75Pyruvate metabolism_Homo sapiens_hsa006200.50974428
76Shigellosis_Homo sapiens_hsa051310.48547267
77Influenza A_Homo sapiens_hsa051640.47876322
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46532120
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46071620
80Leishmaniasis_Homo sapiens_hsa051400.44636134
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44613227
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43364200
83Epstein-Barr virus infection_Homo sapiens_hsa051690.42354116
84Basal transcription factors_Homo sapiens_hsa030220.42336769
85HTLV-I infection_Homo sapiens_hsa051660.42190778
86Fatty acid degradation_Homo sapiens_hsa000710.41622693
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40153281
88Notch signaling pathway_Homo sapiens_hsa043300.37845712
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36349437
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36305585
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35972155
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.35960301
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34784001
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.34755956
95Biosynthesis of amino acids_Homo sapiens_hsa012300.33799184
96Tyrosine metabolism_Homo sapiens_hsa003500.33793577
97Oocyte meiosis_Homo sapiens_hsa041140.32178139
98Fructose and mannose metabolism_Homo sapiens_hsa000510.29788199
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26064521
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24820684

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