DNER

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.83952622
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82938622
3neuron cell-cell adhesion (GO:0007158)5.48032726
4locomotory exploration behavior (GO:0035641)5.44268965
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28823053
6synaptic vesicle exocytosis (GO:0016079)5.26525878
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.24036402
8synaptic vesicle maturation (GO:0016188)5.23828310
9layer formation in cerebral cortex (GO:0021819)5.23585402
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11334174
11gamma-aminobutyric acid transport (GO:0015812)5.03927226
12protein localization to synapse (GO:0035418)4.86632419
13glutamate secretion (GO:0014047)4.81312593
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.79489103
15regulation of glutamate receptor signaling pathway (GO:1900449)4.70616239
16neurotransmitter secretion (GO:0007269)4.64308690
17exploration behavior (GO:0035640)4.58786988
18establishment of mitochondrion localization (GO:0051654)4.53561674
19regulation of synaptic vesicle exocytosis (GO:2000300)4.52942669
20glutamate receptor signaling pathway (GO:0007215)4.38413361
21neuronal action potential propagation (GO:0019227)4.30326084
22positive regulation of synapse maturation (GO:0090129)4.30133376
23neuron recognition (GO:0008038)4.22719241
24cerebellar granule cell differentiation (GO:0021707)4.20319516
25synaptic transmission, glutamatergic (GO:0035249)4.14747354
26pyrimidine nucleobase catabolic process (GO:0006208)4.12889686
27dendritic spine morphogenesis (GO:0060997)4.08010758
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02557732
29regulation of synaptic vesicle transport (GO:1902803)3.99529051
30positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.93176778
31response to pheromone (GO:0019236)3.93110273
32regulation of synapse structural plasticity (GO:0051823)3.92671866
33neurotransmitter-gated ion channel clustering (GO:0072578)3.91633405
34neuron-neuron synaptic transmission (GO:0007270)3.91563353
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88916102
36mechanosensory behavior (GO:0007638)3.87426986
37neuronal ion channel clustering (GO:0045161)3.85353787
38proline transport (GO:0015824)3.85282783
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84064390
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.83910327
41cerebellar Purkinje cell differentiation (GO:0021702)3.79974569
42dendrite morphogenesis (GO:0048813)3.79744358
43neurofilament cytoskeleton organization (GO:0060052)3.79540787
44regulation of neuronal synaptic plasticity (GO:0048168)3.79463405
45cellular potassium ion homeostasis (GO:0030007)3.78972683
46axonal fasciculation (GO:0007413)3.78577703
47neurotransmitter transport (GO:0006836)3.78183559
48postsynaptic membrane organization (GO:0001941)3.77816726
49mitochondrion transport along microtubule (GO:0047497)3.76241448
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.76241448
51negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.74351385
52transmission of nerve impulse (GO:0019226)3.72847981
53long-term memory (GO:0007616)3.67387596
54behavioral response to nicotine (GO:0035095)3.63899206
55cerebellar Purkinje cell layer development (GO:0021680)3.56279634
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55983774
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48711030
58short-term memory (GO:0007614)3.48450075
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47949525
60regulation of neurotransmitter levels (GO:0001505)3.47774547
61nucleobase catabolic process (GO:0046113)3.46975167
62positive regulation of synapse assembly (GO:0051965)3.44600135
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.44481879
64positive regulation of membrane potential (GO:0045838)3.44374908
65sodium ion export (GO:0071436)3.43766783
66regulation of synapse maturation (GO:0090128)3.43466890
67cell migration in hindbrain (GO:0021535)3.41244048
68synaptic vesicle endocytosis (GO:0048488)3.39726333
69regulation of postsynaptic membrane potential (GO:0060078)3.34405138
70negative regulation of microtubule polymerization (GO:0031115)3.33757832
71* synapse assembly (GO:0007416)3.33662753
72presynaptic membrane assembly (GO:0097105)3.33365677
73cell differentiation in hindbrain (GO:0021533)3.31359969
74central nervous system myelination (GO:0022010)3.29847411
75axon ensheathment in central nervous system (GO:0032291)3.29847411
76auditory behavior (GO:0031223)3.28233686
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28121674
78activation of protein kinase A activity (GO:0034199)3.27569103
79central nervous system projection neuron axonogenesis (GO:0021952)3.27187540
80regulation of vesicle fusion (GO:0031338)3.24891032
81presynaptic membrane organization (GO:0097090)3.24205513
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.20805953
83mating behavior (GO:0007617)3.19860077
84axon extension (GO:0048675)3.19746146
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16178643
86regulation of dendritic spine morphogenesis (GO:0061001)3.15943547
87cellular sodium ion homeostasis (GO:0006883)3.15922782
88response to auditory stimulus (GO:0010996)3.14554035
89regulation of neurotransmitter secretion (GO:0046928)3.14220249
90neuromuscular process controlling balance (GO:0050885)3.13876619
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.11670836
92prepulse inhibition (GO:0060134)3.10951989
93social behavior (GO:0035176)3.07553700
94intraspecies interaction between organisms (GO:0051703)3.07553700
95positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05876915
96neuromuscular synaptic transmission (GO:0007274)3.05187289
97glycine transport (GO:0015816)3.04321439
98positive regulation of dendritic spine development (GO:0060999)3.03987373
99positive regulation of potassium ion transmembrane transport (GO:1901381)3.03642533
100* synapse organization (GO:0050808)3.03183347
101startle response (GO:0001964)3.02021770
102regulation of synaptic plasticity (GO:0048167)3.01195921
103cell communication by electrical coupling (GO:0010644)3.00415309
104retinal ganglion cell axon guidance (GO:0031290)2.99322614
105membrane depolarization (GO:0051899)2.97939980
106learning (GO:0007612)2.97124782
107positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96860693
108long-term synaptic potentiation (GO:0060291)2.95007124
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93787256
110cerebral cortex radially oriented cell migration (GO:0021799)2.93147718
111membrane hyperpolarization (GO:0060081)2.92347132
112potassium ion homeostasis (GO:0055075)2.92001444
113regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91779306
114organelle transport along microtubule (GO:0072384)2.90883870
115clathrin coat assembly (GO:0048268)2.89336645
116behavioral response to cocaine (GO:0048148)2.88934588
117regulation of synapse assembly (GO:0051963)2.88415457
118adult walking behavior (GO:0007628)2.88398127
119synaptic transmission (GO:0007268)2.87466180
120substrate-independent telencephalic tangential migration (GO:0021826)2.86589326
121substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.86589326
122membrane depolarization during action potential (GO:0086010)2.86554723
123adult behavior (GO:0030534)2.84908708
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82830254
125protein localization to cilium (GO:0061512)2.79746357
126negative regulation of axonogenesis (GO:0050771)2.79584916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.43364894
2GBX2_23144817_ChIP-Seq_PC3_Human3.43454592
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17906077
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17831579
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17214931
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77240971
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77240971
8REST_21632747_ChIP-Seq_MESCs_Mouse2.72861076
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63843694
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63427490
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63183634
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.62358323
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60188995
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51603155
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47937908
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.38044595
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33554277
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31997185
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26943148
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26392774
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23079345
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21663327
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19905801
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.16343612
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11978875
26AR_21572438_ChIP-Seq_LNCaP_Human2.10519168
27RARB_27405468_Chip-Seq_BRAIN_Mouse2.03036794
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99315159
29TAF15_26573619_Chip-Seq_HEK293_Human1.93728359
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91515358
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75703806
32ZNF274_21170338_ChIP-Seq_K562_Hela1.70903467
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63461247
34SMAD4_21799915_ChIP-Seq_A2780_Human1.61225644
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60898349
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59926892
37* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54220017
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53575745
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52458878
40* CBX2_27304074_Chip-Seq_ESCs_Mouse1.51521815
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51027556
42IGF1R_20145208_ChIP-Seq_DFB_Human1.50841797
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.49996011
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45185211
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42843360
46P300_19829295_ChIP-Seq_ESCs_Human1.40643966
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38421226
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.38125737
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.33551799
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33197543
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32651629
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31970194
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31626617
54RNF2_27304074_Chip-Seq_NSC_Mouse1.29929517
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.28790617
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27740970
57* AR_25329375_ChIP-Seq_VCAP_Human1.26420068
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.23693136
59VDR_22108803_ChIP-Seq_LS180_Human1.21648984
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20460754
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20360956
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.20035964
63* STAT3_23295773_ChIP-Seq_U87_Human1.17297541
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17020899
65* AR_19668381_ChIP-Seq_PC3_Human1.16472851
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15400555
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15042555
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10461505
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.10411579
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09151739
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08703232
72* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08089542
73LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07664059
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.06374679
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05657423
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04488353
77DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03538533
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03352686
79FUS_26573619_Chip-Seq_HEK293_Human1.03197624
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02647050
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02541326
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02499626
83TCF4_23295773_ChIP-Seq_U87_Human1.02236707
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.01898875
85ER_23166858_ChIP-Seq_MCF-7_Human1.01822411
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01735329
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00617261
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00404132
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00404132
90AHR_22903824_ChIP-Seq_MCF-7_Human1.00079348
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99331420
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98979340
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.98357879
94SOX9_26525672_Chip-Seq_HEART_Mouse0.98163855
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98021517
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.97715712
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97576215
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97405996
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.96918529
100EWS_26573619_Chip-Seq_HEK293_Human0.96232935
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95739693
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95076452
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94014572
104JUN_21703547_ChIP-Seq_K562_Human0.93978298
105* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92419104
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91672441
107* NANOG_18555785_Chip-Seq_ESCs_Mouse0.91291227
108BCAT_22108803_ChIP-Seq_LS180_Human0.90918237
109KDM2B_26808549_Chip-Seq_K562_Human0.90480277
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.89712181
111PRDM14_20953172_ChIP-Seq_ESCs_Human0.89351814
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88813489
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.85607499
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83119584
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82341226
116TP53_18474530_ChIP-ChIP_U2OS_Human0.81441935
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80640412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.48974779
2MP0003880_abnormal_central_pattern4.31737530
3* MP0003635_abnormal_synaptic_transmissio3.99235146
4MP0004270_analgesia3.53205363
5MP0009046_muscle_twitch3.46572907
6MP0005423_abnormal_somatic_nervous3.28000047
7MP0009745_abnormal_behavioral_response3.25631218
8MP0002063_abnormal_learning/memory/cond3.18448002
9MP0002064_seizures3.04312853
10MP0001968_abnormal_touch/_nociception2.88614491
11MP0002734_abnormal_mechanical_nocicepti2.87938890
12MP0002572_abnormal_emotion/affect_behav2.75495917
13MP0002272_abnormal_nervous_system2.52916109
14MP0001486_abnormal_startle_reflex2.51395010
15MP0002735_abnormal_chemical_nociception2.48079481
16MP0001440_abnormal_grooming_behavior2.44412008
17MP0002733_abnormal_thermal_nociception2.31218239
18MP0000778_abnormal_nervous_system2.30290682
19MP0006276_abnormal_autonomic_nervous2.21137414
20MP0001984_abnormal_olfaction2.21111597
21* MP0002184_abnormal_innervation2.20974150
22MP0002736_abnormal_nociception_after2.19964654
23MP0002067_abnormal_sensory_capabilities2.18733748
24MP0003329_amyloid_beta_deposits2.16753392
25MP0001970_abnormal_pain_threshold2.09817881
26MP0001501_abnormal_sleep_pattern2.09135677
27MP0008569_lethality_at_weaning2.05759604
28MP0002557_abnormal_social/conspecific_i1.99114797
29MP0004924_abnormal_behavior1.85337974
30MP0005386_behavior/neurological_phenoty1.85337974
31MP0004858_abnormal_nervous_system1.79557197
32MP0004811_abnormal_neuron_physiology1.70764878
33MP0000955_abnormal_spinal_cord1.70487984
34MP0004885_abnormal_endolymph1.58304454
35MP0003121_genomic_imprinting1.57599374
36MP0002909_abnormal_adrenal_gland1.57115462
37MP0009780_abnormal_chondrocyte_physiolo1.56975759
38MP0004142_abnormal_muscle_tone1.53762579
39MP0002882_abnormal_neuron_morphology1.52554401
40MP0005645_abnormal_hypothalamus_physiol1.52140548
41* MP0002066_abnormal_motor_capabilities/c1.48311053
42MP0002822_catalepsy1.44019681
43MP0000566_synostosis1.43785843
44MP0001502_abnormal_circadian_rhythm1.39101367
45MP0004742_abnormal_vestibular_system1.34393336
46MP0001529_abnormal_vocalization1.32650023
47MP0001905_abnormal_dopamine_level1.30882206
48* MP0002152_abnormal_brain_morphology1.26935189
49MP0003879_abnormal_hair_cell1.26210705
50MP0003122_maternal_imprinting1.23876223
51MP0005646_abnormal_pituitary_gland1.22502650
52MP0001188_hyperpigmentation1.21763441
53MP0004145_abnormal_muscle_electrophysio1.20590282
54MP0002653_abnormal_ependyma_morphology1.16392230
55MP0003633_abnormal_nervous_system1.10248496
56MP0005499_abnormal_olfactory_system1.08333038
57MP0005394_taste/olfaction_phenotype1.08333038
58MP0003787_abnormal_imprinting1.07254260
59MP0003631_nervous_system_phenotype1.06117287
60MP0000569_abnormal_digit_pigmentation1.04604993
61MP0010386_abnormal_urinary_bladder1.02567792
62MP0002229_neurodegeneration1.01525176
63MP0003632_abnormal_nervous_system1.00918313
64MP0000604_amyloidosis0.99347687
65MP0003123_paternal_imprinting0.98197203
66MP0006292_abnormal_olfactory_placode0.96024133
67MP0005253_abnormal_eye_physiology0.95010242
68MP0005551_abnormal_eye_electrophysiolog0.94975357
69* MP0003634_abnormal_glial_cell0.94627495
70MP0004133_heterotaxia0.94329483
71MP0000751_myopathy0.93605060
72MP0002752_abnormal_somatic_nervous0.93462243
73MP0005187_abnormal_penis_morphology0.92632373
74MP0002069_abnormal_eating/drinking_beha0.89850231
75MP0001963_abnormal_hearing_physiology0.89711386
76MP0002638_abnormal_pupillary_reflex0.89706794
77MP0000631_abnormal_neuroendocrine_gland0.89198777
78MP0002837_dystrophic_cardiac_calcinosis0.88427831
79MP0003137_abnormal_impulse_conducting0.87592284
80MP0008877_abnormal_DNA_methylation0.87191661
81MP0001986_abnormal_taste_sensitivity0.85200409
82MP0002751_abnormal_autonomic_nervous0.84380652
83MP0000920_abnormal_myelination0.82719687
84MP0001177_atelectasis0.81842460
85MP0000013_abnormal_adipose_tissue0.80947060
86MP0004085_abnormal_heartbeat0.80426306
87MP0008872_abnormal_physiological_respon0.80198714
88MP0003690_abnormal_glial_cell0.79788154
89MP0003938_abnormal_ear_development0.78038581
90* MP0003861_abnormal_nervous_system0.77579639
91MP0004215_abnormal_myocardial_fiber0.77032434
92MP0001299_abnormal_eye_distance/0.76368046
93MP0002102_abnormal_ear_morphology0.76248696
94MP0003890_abnormal_embryonic-extraembry0.75802776
95MP0006072_abnormal_retinal_apoptosis0.71630001
96MP0005195_abnormal_posterior_eye0.70868020
97MP0004484_altered_response_of0.70377536
98MP0002090_abnormal_vision0.68709059
99MP0005248_abnormal_Harderian_gland0.68013481
100MP0005535_abnormal_body_temperature0.67795161
101MP0000537_abnormal_urethra_morphology0.64424376
102MP0003011_delayed_dark_adaptation0.63417456
103MP0001348_abnormal_lacrimal_gland0.63005975
104MP0008874_decreased_physiological_sensi0.62027691
105MP0002082_postnatal_lethality0.60512921
106MP0010770_preweaning_lethality0.60512921
107MP0001943_abnormal_respiration0.60188894
108MP0000026_abnormal_inner_ear0.60142022
109MP0010769_abnormal_survival0.59993446
110MP0003283_abnormal_digestive_organ0.59953465
111MP0003119_abnormal_digestive_system0.59312923
112MP0001485_abnormal_pinna_reflex0.59051882
113MP0000049_abnormal_middle_ear0.58902810
114MP0008961_abnormal_basal_metabolism0.58473685
115MP0005623_abnormal_meninges_morphology0.58250813
116MP0004233_abnormal_muscle_weight0.58234116
117MP0008789_abnormal_olfactory_epithelium0.58215438
118MP0010768_mortality/aging0.56293149

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.65765015
2Visual hallucinations (HP:0002367)5.60775177
3Myokymia (HP:0002411)5.53664190
4Focal seizures (HP:0007359)5.29366887
5Progressive cerebellar ataxia (HP:0002073)4.74954187
6Atonic seizures (HP:0010819)4.43248631
7Epileptic encephalopathy (HP:0200134)4.42663238
8Febrile seizures (HP:0002373)4.14004996
9Absence seizures (HP:0002121)4.09051436
10Mutism (HP:0002300)3.93768260
11Action tremor (HP:0002345)3.93050728
12Supranuclear gaze palsy (HP:0000605)3.87768097
13Broad-based gait (HP:0002136)3.72890311
14Dialeptic seizures (HP:0011146)3.64508228
15Generalized tonic-clonic seizures (HP:0002069)3.56365582
16Limb dystonia (HP:0002451)3.48281473
17Progressive inability to walk (HP:0002505)3.41037013
18Hyperventilation (HP:0002883)3.28709521
19Amyotrophic lateral sclerosis (HP:0007354)3.26402538
20Neurofibrillary tangles (HP:0002185)3.22976587
21Abnormality of binocular vision (HP:0011514)3.20842067
22Diplopia (HP:0000651)3.20842067
23Gaze-evoked nystagmus (HP:0000640)3.20295838
24Ankle clonus (HP:0011448)3.17934297
25Poor eye contact (HP:0000817)3.14234588
26Excessive salivation (HP:0003781)3.14156270
27Drooling (HP:0002307)3.14156270
28Dysdiadochokinesis (HP:0002075)3.12226878
29Truncal ataxia (HP:0002078)3.10384360
30Abnormality of the corticospinal tract (HP:0002492)3.10120678
31Cerebral inclusion bodies (HP:0100314)3.08915830
32Hemiparesis (HP:0001269)3.01307585
33Abnormal eating behavior (HP:0100738)2.99419284
34Impaired social interactions (HP:0000735)2.98870279
35Abnormal social behavior (HP:0012433)2.98870279
36Polyphagia (HP:0002591)2.94478635
37Genetic anticipation (HP:0003743)2.90115549
38Papilledema (HP:0001085)2.86753285
39Depression (HP:0000716)2.85046044
40Dysmetria (HP:0001310)2.79748642
41Anxiety (HP:0000739)2.67459949
42Scanning speech (HP:0002168)2.67426349
43Agitation (HP:0000713)2.65176224
44Intention tremor (HP:0002080)2.59445425
45Impaired vibration sensation in the lower limbs (HP:0002166)2.57902613
46Amblyopia (HP:0000646)2.57108163
47Termporal pattern (HP:0011008)2.55711421
48Insidious onset (HP:0003587)2.55711421
49Urinary bladder sphincter dysfunction (HP:0002839)2.52773251
50Spastic gait (HP:0002064)2.52703061
51Absent speech (HP:0001344)2.47843579
52Cortical dysplasia (HP:0002539)2.47618388
53Congenital primary aphakia (HP:0007707)2.47379724
54EEG with generalized epileptiform discharges (HP:0011198)2.46359985
55Medial flaring of the eyebrow (HP:0010747)2.46193863
56Impaired smooth pursuit (HP:0007772)2.45917949
57Inability to walk (HP:0002540)2.45843119
58Hemiplegia (HP:0002301)2.45344130
59Epileptiform EEG discharges (HP:0011182)2.45006445
60Akinesia (HP:0002304)2.43822968
61Fetal akinesia sequence (HP:0001989)2.43454047
62Urinary urgency (HP:0000012)2.41732342
63Hypsarrhythmia (HP:0002521)2.38256719
64Postural instability (HP:0002172)2.38149584
65Pheochromocytoma (HP:0002666)2.37340137
66Nephrogenic diabetes insipidus (HP:0009806)2.33779899
67Megalencephaly (HP:0001355)2.31113048
68Inappropriate behavior (HP:0000719)2.30266013
69Abnormality of ocular smooth pursuit (HP:0000617)2.26669749
70Pachygyria (HP:0001302)2.24027141
71Morphological abnormality of the pyramidal tract (HP:0002062)2.21074409
72Hypoplasia of the brainstem (HP:0002365)2.20852463
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20852463
74Abnormality of the lower motor neuron (HP:0002366)2.17692000
75Status epilepticus (HP:0002133)2.17061486
76Lissencephaly (HP:0001339)2.15465571
77Torticollis (HP:0000473)2.12180169
78Generalized myoclonic seizures (HP:0002123)2.11713516
79Stereotypic behavior (HP:0000733)2.11468924
80Neuronal loss in central nervous system (HP:0002529)2.11462282
81Bradykinesia (HP:0002067)2.11428671
82Neuroendocrine neoplasm (HP:0100634)2.10463840
83Peripheral hypomyelination (HP:0007182)2.09742314
84Gait imbalance (HP:0002141)2.08246986
85Hepatoblastoma (HP:0002884)2.06601695
86Genital tract atresia (HP:0001827)2.04161699
87Lower limb muscle weakness (HP:0007340)2.03948368
88Abnormality of salivation (HP:0100755)2.03897359
89Focal dystonia (HP:0004373)2.02878940
90Vaginal atresia (HP:0000148)2.02444731
91Hypoplasia of the corpus callosum (HP:0002079)2.02322777
92Blue irides (HP:0000635)2.00990924
93Gait ataxia (HP:0002066)1.97611050
94Poor suck (HP:0002033)1.97220096
95Failure to thrive in infancy (HP:0001531)1.96723987
96Specific learning disability (HP:0001328)1.95950811
97Aqueductal stenosis (HP:0002410)1.94531042
98Psychosis (HP:0000709)1.94466299
99Apathy (HP:0000741)1.92040755
100Obstructive sleep apnea (HP:0002870)1.90967703
101Protruding tongue (HP:0010808)1.89931761
102Split foot (HP:0001839)1.87700646
103Retinal dysplasia (HP:0007973)1.87365150
104Sleep apnea (HP:0010535)1.86750624
105Postural tremor (HP:0002174)1.84453732
106Nephronophthisis (HP:0000090)1.84002078
107Dysmetric saccades (HP:0000641)1.82670353
108Abnormality of the labia minora (HP:0012880)1.81444456
109Myotonia (HP:0002486)1.81336757
110Oligodactyly (hands) (HP:0001180)1.80500069
111Spastic tetraplegia (HP:0002510)1.79911043
112Exotropia (HP:0000577)1.78604803
113Atrophy/Degeneration involving motor neurons (HP:0007373)1.77919306
114Esotropia (HP:0000565)1.77739028
115Incomplete penetrance (HP:0003829)1.77108899
116Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76333525
117Degeneration of the lateral corticospinal tracts (HP:0002314)1.76333525
118Molar tooth sign on MRI (HP:0002419)1.76184002
119Abnormality of midbrain morphology (HP:0002418)1.76184002
120Horizontal nystagmus (HP:0000666)1.75691318
121True hermaphroditism (HP:0010459)1.75255793
122Impaired vibratory sensation (HP:0002495)1.75228822
123Hypoventilation (HP:0002791)1.74819655
124Muscular hypotonia of the trunk (HP:0008936)1.71946832
125Pancreatic fibrosis (HP:0100732)1.68811899
126Poor coordination (HP:0002370)1.64932218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.37477632
2MAP3K93.70457774
3NTRK33.65597762
4MAP3K43.14927634
5MINK12.85091584
6NTRK22.74988531
7MAP2K72.70479653
8PNCK2.27896467
9CASK2.07670522
10EPHA42.03322990
11PAK62.02161847
12MAP2K41.97831374
13MAP3K121.97065041
14PHKG21.97060056
15PHKG11.97060056
16MAPK131.87930171
17NTRK11.81675742
18DAPK21.74550789
19SIK21.65494353
20EPHA31.58053373
21TNIK1.55657808
22KSR11.53504931
23CAMKK11.50687305
24CDK51.48414338
25LATS21.43133204
26GRK51.42328584
27CAMKK21.40588830
28KSR21.38575803
29UHMK11.35758007
30PLK21.27683196
31CSNK1G21.26890737
32PRKCG1.24907999
33DYRK21.18362385
34TYRO31.10064980
35ERBB31.07803347
36CDK191.02112409
37DYRK1A1.01067886
38PAK31.00057680
39CDK140.98213239
40CDK180.98021379
41CAMK2A0.97627729
42CDK150.96225816
43RIPK40.96126574
44TRIM280.94704761
45PRKD30.90607847
46DYRK30.90086200
47STK380.88101320
48PKN10.86699103
49ARAF0.84641681
50FES0.84214699
51DAPK10.84030555
52CDK11A0.83758311
53EPHB20.83704014
54CAMK2B0.83410326
55RET0.81408407
56STK110.80834071
57CSNK1G30.79269115
58CAMK1G0.78649369
59DYRK1B0.77295342
60MARK20.75566120
61SCYL20.74131842
62MAP3K60.74069248
63SGK2230.73810895
64SGK4940.73810895
65PRPF4B0.73702323
66OXSR10.71204085
67TESK10.70319901
68PRKCE0.68712249
69MAP4K20.68610494
70MAP3K20.68356388
71ALK0.66617706
72CAMK10.66092995
73PRKCZ0.64905077
74FGFR20.64835671
75CSNK1A1L0.63372869
76BMPR1B0.63173779
77LIMK10.61769079
78WNK10.61192463
79BCR0.60774130
80PRKCH0.59259350
81LMTK20.57011775
82CAMK2D0.56800822
83SGK10.55232173
84MAPK150.54961984
85STK160.54898122
86CAMK2G0.53524483
87WNK30.53199168
88FYN0.51378257
89FER0.49626364
90MAPK120.49622241
91SGK20.49260000
92RPS6KA20.48587335
93PRKACA0.48168144
94MUSK0.48146629
95ROCK20.47557239
96CSNK1D0.47433283
97PINK10.44891335
98RIPK10.44841583
99CSNK1A10.44234858
100RPS6KA30.43762004
101ICK0.43724033
102WNK40.43043510
103STK390.41509757
104CSNK1G10.40368193
105ERBB40.40221261
106ERBB20.40122297
107FGR0.39446659
108MAPKAPK50.39336476
109BMPR20.38951400
110PRKG10.38821760
111MAP3K130.37760854
112MAPK100.36412616
113CSNK1E0.35396608
114CAMK40.35263774
115SGK30.34088445
116RAF10.33880289
117TAOK10.33451465
118SIK30.33307641
119PRKAA10.32876708
120PRKDC0.29599551
121PRKCA0.28062876
122MAPK90.25986081
123PRKACG0.25674583
124GRK10.24742738

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.13384774
2Synaptic vesicle cycle_Homo sapiens_hsa047213.26632395
3GABAergic synapse_Homo sapiens_hsa047272.96629264
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81703561
5Glutamatergic synapse_Homo sapiens_hsa047242.63043636
6Circadian entrainment_Homo sapiens_hsa047132.51666918
7Long-term potentiation_Homo sapiens_hsa047202.46927441
8Morphine addiction_Homo sapiens_hsa050322.46226784
9Olfactory transduction_Homo sapiens_hsa047402.35541858
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21571530
11Dopaminergic synapse_Homo sapiens_hsa047282.12913396
12Amphetamine addiction_Homo sapiens_hsa050312.11751726
13Taste transduction_Homo sapiens_hsa047422.04890926
14Long-term depression_Homo sapiens_hsa047302.01233170
15Salivary secretion_Homo sapiens_hsa049702.00128703
16Cholinergic synapse_Homo sapiens_hsa047251.82950874
17Insulin secretion_Homo sapiens_hsa049111.77731181
18Serotonergic synapse_Homo sapiens_hsa047261.77375686
19Gastric acid secretion_Homo sapiens_hsa049711.74408856
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60964322
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60506976
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58988355
23Cocaine addiction_Homo sapiens_hsa050301.58090885
24Renin secretion_Homo sapiens_hsa049241.51949520
25Collecting duct acid secretion_Homo sapiens_hsa049661.51480763
26Oxytocin signaling pathway_Homo sapiens_hsa049211.45745458
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44225574
28Axon guidance_Homo sapiens_hsa043601.44065837
29Gap junction_Homo sapiens_hsa045401.43552256
30Calcium signaling pathway_Homo sapiens_hsa040201.37760148
31GnRH signaling pathway_Homo sapiens_hsa049121.30774545
32Cardiac muscle contraction_Homo sapiens_hsa042601.28385885
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24127600
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24033205
35Estrogen signaling pathway_Homo sapiens_hsa049151.22953514
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19769591
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15321109
38cAMP signaling pathway_Homo sapiens_hsa040241.11669774
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09636721
40Type II diabetes mellitus_Homo sapiens_hsa049301.07122538
41Nitrogen metabolism_Homo sapiens_hsa009101.03971375
42ErbB signaling pathway_Homo sapiens_hsa040121.02012809
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00288503
44Melanogenesis_Homo sapiens_hsa049160.97982598
45Vibrio cholerae infection_Homo sapiens_hsa051100.97459687
46Glioma_Homo sapiens_hsa052140.97000425
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91776267
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90068625
49Steroid biosynthesis_Homo sapiens_hsa001000.86240873
50Butanoate metabolism_Homo sapiens_hsa006500.85034565
51Dorso-ventral axis formation_Homo sapiens_hsa043200.84125396
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83945345
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83194666
54Alzheimers disease_Homo sapiens_hsa050100.82889153
55Oocyte meiosis_Homo sapiens_hsa041140.81697708
56Pancreatic secretion_Homo sapiens_hsa049720.79240735
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.78266164
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77134099
59Thyroid hormone synthesis_Homo sapiens_hsa049180.76668632
60Oxidative phosphorylation_Homo sapiens_hsa001900.75832325
61Phototransduction_Homo sapiens_hsa047440.75404826
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.74339651
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73551235
64Type I diabetes mellitus_Homo sapiens_hsa049400.73181714
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71804114
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70898536
67Choline metabolism in cancer_Homo sapiens_hsa052310.67174408
68Dilated cardiomyopathy_Homo sapiens_hsa054140.66613282
69MAPK signaling pathway_Homo sapiens_hsa040100.64807185
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60980997
71Alcoholism_Homo sapiens_hsa050340.60266568
72Parkinsons disease_Homo sapiens_hsa050120.60247444
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60002004
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56688655
75Endometrial cancer_Homo sapiens_hsa052130.56648934
76Hippo signaling pathway_Homo sapiens_hsa043900.56477177
77Regulation of autophagy_Homo sapiens_hsa041400.56269516
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.55980143
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.55734030
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54339466
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53947178
82Renal cell carcinoma_Homo sapiens_hsa052110.53864664
83Vitamin B6 metabolism_Homo sapiens_hsa007500.52992876
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52152803
85Ras signaling pathway_Homo sapiens_hsa040140.51975802
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49396800
87Bile secretion_Homo sapiens_hsa049760.48301401
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48230639
89beta-Alanine metabolism_Homo sapiens_hsa004100.47741642
90VEGF signaling pathway_Homo sapiens_hsa043700.47127878
91Hedgehog signaling pathway_Homo sapiens_hsa043400.45994131
92Rap1 signaling pathway_Homo sapiens_hsa040150.45353099
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43800450
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43648600
95Protein export_Homo sapiens_hsa030600.42568070
96Inositol phosphate metabolism_Homo sapiens_hsa005620.42490688
97Colorectal cancer_Homo sapiens_hsa052100.42251129
98Huntingtons disease_Homo sapiens_hsa050160.41567682
99Wnt signaling pathway_Homo sapiens_hsa043100.41424770
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40967054
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40741661
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39927879
103Glucagon signaling pathway_Homo sapiens_hsa049220.39790226
104Endocytosis_Homo sapiens_hsa041440.37922763
105mTOR signaling pathway_Homo sapiens_hsa041500.36075637
106Basal cell carcinoma_Homo sapiens_hsa052170.35628212
107Circadian rhythm_Homo sapiens_hsa047100.35618460
108Fatty acid biosynthesis_Homo sapiens_hsa000610.35011870
109Prion diseases_Homo sapiens_hsa050200.34899247
110Insulin signaling pathway_Homo sapiens_hsa049100.34737973
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32929913
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32718704
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32607120
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31019139
115Ovarian steroidogenesis_Homo sapiens_hsa049130.30875170
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29870383
117Arginine and proline metabolism_Homo sapiens_hsa003300.26875721

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