DNHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.93831577
2multicellular organism reproduction (GO:0032504)9.83618244
3sperm-egg recognition (GO:0035036)9.82326651
4epithelial cilium movement (GO:0003351)9.79770273
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.37918434
6acrosome assembly (GO:0001675)9.35098012
7acrosome reaction (GO:0007340)9.28083688
8cilium movement (GO:0003341)9.18305386
9motile cilium assembly (GO:0044458)9.16481633
10binding of sperm to zona pellucida (GO:0007339)9.10134612
11plasma membrane fusion (GO:0045026)8.94544969
12cell-cell recognition (GO:0009988)8.80386970
13synaptonemal complex organization (GO:0070193)8.75745806
14spermatid development (GO:0007286)8.53573494
15synaptonemal complex assembly (GO:0007130)8.18081233
16reproduction (GO:0000003)7.86441051
17DNA methylation involved in gamete generation (GO:0043046)7.72713021
18regulation of cilium movement (GO:0003352)7.61726794
19male meiosis I (GO:0007141)6.86798985
20single fertilization (GO:0007338)6.78058463
21sperm capacitation (GO:0048240)6.42219493
22negative regulation of inclusion body assembly (GO:0090084)6.16125328
23cell wall macromolecule catabolic process (GO:0016998)6.09127225
24cell wall macromolecule metabolic process (GO:0044036)6.09127225
25fertilization (GO:0009566)6.04632076
26ventricular system development (GO:0021591)6.01711034
27chromosome organization involved in meiosis (GO:0070192)5.71434715
28meiotic nuclear division (GO:0007126)5.61332295
29meiosis I (GO:0007127)5.50534497
30positive regulation of gamma-delta T cell activation (GO:0046645)5.46805208
31spermatogenesis (GO:0007283)5.28900317
32male gamete generation (GO:0048232)5.26849330
33meiotic cell cycle (GO:0051321)5.24524200
34germ cell development (GO:0007281)5.12462367
35protein localization to cilium (GO:0061512)5.10678165
36cellular process involved in reproduction in multicellular organism (GO:0022412)5.02420811
37seminiferous tubule development (GO:0072520)4.96828809
38gamete generation (GO:0007276)4.83851787
39gene silencing by RNA (GO:0031047)4.74925922
40regulation of inclusion body assembly (GO:0090083)4.69122699
41left/right pattern formation (GO:0060972)4.68650124
42regulation of gamma-delta T cell differentiation (GO:0045586)4.65607137
43histone H3-K4 trimethylation (GO:0080182)4.61758632
44genitalia morphogenesis (GO:0035112)4.56990821
45regulation of gamma-delta T cell activation (GO:0046643)4.50719973
46regulation of microtubule-based movement (GO:0060632)4.47403498
47histone H3-K36 demethylation (GO:0070544)4.46908011
48cell recognition (GO:0008037)4.41018230
49organic cation transport (GO:0015695)4.36624736
50mannose metabolic process (GO:0006013)4.36160472
51regulation of histone H3-K27 methylation (GO:0061085)4.35752291
52intraciliary transport (GO:0042073)4.31034299
53calcium ion-dependent exocytosis (GO:0017156)4.29866432
54negative thymic T cell selection (GO:0045060)4.20067063
55monoubiquitinated protein deubiquitination (GO:0035520)4.17461217
56negative regulation of organelle assembly (GO:1902116)4.15387321
57positive thymic T cell selection (GO:0045059)4.10255010
58axoneme assembly (GO:0035082)4.08584534
59negative T cell selection (GO:0043383)4.02572946
60B cell receptor signaling pathway (GO:0050853)4.00895733
61positive regulation of granulocyte differentiation (GO:0030854)3.94708613
62regulation of meiosis I (GO:0060631)3.93287519
63positive T cell selection (GO:0043368)3.93101851
64microtubule severing (GO:0051013)3.89637597
65microtubule depolymerization (GO:0007019)3.89599490
66regulation of protein polyubiquitination (GO:1902914)3.88629737
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87094931
68negative regulation of cell killing (GO:0031342)3.87094931
69multicellular organismal reproductive process (GO:0048609)3.80757895
70regulation of B cell receptor signaling pathway (GO:0050855)3.80678178
71thymic T cell selection (GO:0045061)3.77477186
72* microtubule-based movement (GO:0007018)3.75251941
73response to muramyl dipeptide (GO:0032495)3.71982314
74lactate metabolic process (GO:0006089)3.70026737
75positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.68800498
76carnitine transmembrane transport (GO:1902603)3.67721939
77histone H3-K9 modification (GO:0061647)3.67670335
78cellular response to ethanol (GO:0071361)3.65410823
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64072502
80protein polyglutamylation (GO:0018095)3.63645848
81T cell selection (GO:0045058)3.62502721
82negative regulation of erythrocyte differentiation (GO:0045647)3.60555348
83regulation of centriole replication (GO:0046599)3.59406927
84carnitine transport (GO:0015879)3.58927569
85amino-acid betaine transport (GO:0015838)3.58927569
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50989127
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.45989823
88antigen processing and presentation of endogenous antigen (GO:0019883)3.40742269
89meiotic cell cycle process (GO:1903046)3.40336818
90peptidyl-lysine trimethylation (GO:0018023)3.39863219
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35256763
92histone H3-K9 demethylation (GO:0033169)3.34589544
93histone lysine demethylation (GO:0070076)3.32301651
94histone H3-K4 methylation (GO:0051568)3.30706480
95histone H3-K9 methylation (GO:0051567)3.30110426
96synapsis (GO:0007129)3.29595462
97cilium organization (GO:0044782)3.28112031
98germinal center formation (GO:0002467)3.27388743
99negative regulation of DNA repair (GO:0045738)3.26218043
100histone demethylation (GO:0016577)3.25516431
101regulation of granulocyte differentiation (GO:0030852)3.19006311
102response to interleukin-15 (GO:0070672)3.17934031
103nuclear pore complex assembly (GO:0051292)3.17335064
104tolerance induction (GO:0002507)3.14073871
105multicellular organismal development (GO:0007275)3.13425681
106phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12962903
107peptidyl-lysine methylation (GO:0018022)3.10790395
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09277870
109cilium assembly (GO:0042384)3.08943649
110alditol metabolic process (GO:0019400)3.07391128
111gene silencing (GO:0016458)3.05997925
112chaperone-mediated protein complex assembly (GO:0051131)3.04815170
113regulation of ARF GTPase activity (GO:0032312)2.98506255
114histone lysine methylation (GO:0034968)2.98227138
115positive regulation of histone deacetylation (GO:0031065)2.96560775
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.94037533
117centriole replication (GO:0007099)2.93669715
118positive regulation of CREB transcription factor activity (GO:0032793)2.92939115
119DNA methylation (GO:0006306)2.92303421
120DNA alkylation (GO:0006305)2.92303421
121peptidyl-glutamic acid modification (GO:0018200)2.90919201
122cilium morphogenesis (GO:0060271)2.90803432
123positive regulation of B cell differentiation (GO:0045579)2.90356692
124positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89522136
125cellular component assembly involved in morphogenesis (GO:0010927)2.89034385
126regulation of ARF protein signal transduction (GO:0032012)2.85348822
127phosphatidylethanolamine biosynthetic process (GO:0006646)2.84482804
128glycerol metabolic process (GO:0006071)2.84385709
129mitotic sister chromatid cohesion (GO:0007064)2.81081056
130protein refolding (GO:0042026)2.78736695
131protein demethylation (GO:0006482)2.77753752
132protein dealkylation (GO:0008214)2.77753752
133negative regulation of T cell mediated immunity (GO:0002710)2.77689562
134CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.76456613
135positive regulation of protein deacetylation (GO:0090312)2.74476920
136polyol catabolic process (GO:0046174)2.72861533
137T cell migration (GO:0072678)2.72320735
138regulation of B cell differentiation (GO:0045577)2.70720256
139histone H4 deacetylation (GO:0070933)2.68910196
140establishment of protein localization to Golgi (GO:0072600)2.67391055
141regulation of MHC class I biosynthetic process (GO:0045343)2.65857216
142negative regulation of B cell mediated immunity (GO:0002713)2.65756164
143negative regulation of immunoglobulin mediated immune response (GO:0002890)2.65756164
144sex differentiation (GO:0007548)2.65282942
145negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.64623483
146regulation of necroptotic process (GO:0060544)2.64271400
147histone H3 deacetylation (GO:0070932)2.64029164
148left/right axis specification (GO:0070986)2.63960856
149natural killer cell differentiation (GO:0001779)2.63877434
150spermatid nucleus differentiation (GO:0007289)2.62316155
151detection of bacterium (GO:0016045)2.61870445
152phosphatidylethanolamine metabolic process (GO:0046337)2.59991581
153regulation of histone H3-K9 methylation (GO:0051570)2.59661991
154protein targeting to Golgi (GO:0000042)2.58553573
155negative regulation of myotube differentiation (GO:0010832)2.57632903
156negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57227725
157regulation of acrosome reaction (GO:0060046)2.56570636
158cellular extravasation (GO:0045123)2.56174832
159macrophage activation involved in immune response (GO:0002281)2.55806582
160positive regulation of Rab GTPase activity (GO:0032851)2.55294103
161regulation of Rab GTPase activity (GO:0032313)2.55294103
162centriole assembly (GO:0098534)2.55066644
163regulation of chromatin binding (GO:0035561)2.54572209
164positive regulation of Rap GTPase activity (GO:0032854)2.54049295
165interkinetic nuclear migration (GO:0022027)2.53311646
166translesion synthesis (GO:0019985)2.51637649
167protein K48-linked deubiquitination (GO:0071108)2.50993613
168B cell homeostasis (GO:0001782)2.50643785
169cellular response to interleukin-15 (GO:0071350)2.50586557
170negative regulation of granulocyte differentiation (GO:0030853)2.50031871
171detection of other organism (GO:0098543)2.48959940
172regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48666753
173interferon-gamma production (GO:0032609)2.48084928
174quaternary ammonium group transport (GO:0015697)2.48082334
175plasma lipoprotein particle assembly (GO:0034377)2.48082007
176Peyers patch development (GO:0048541)2.46396207
177mucosal-associated lymphoid tissue development (GO:0048537)2.46396207
178cellular response to exogenous dsRNA (GO:0071360)2.46053215
179negative regulation of leukocyte mediated immunity (GO:0002704)2.44201380
180phospholipid efflux (GO:0033700)2.43847102
181glycolytic process (GO:0006096)2.43608380
182retrograde transport, vesicle recycling within Golgi (GO:0000301)2.43383816
183nucleoside diphosphate phosphorylation (GO:0006165)2.42155537
184snRNA transcription (GO:0009301)2.42072134
185negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.41585588
186negative regulation of adaptive immune response (GO:0002820)2.36351594
187cilium or flagellum-dependent cell motility (GO:0001539)19.6112950
188piRNA metabolic process (GO:0034587)12.7529823
189fusion of sperm to egg plasma membrane (GO:0007342)11.6631054
190axonemal dynein complex assembly (GO:0070286)11.2249781
191sperm motility (GO:0030317)10.9547666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.32406624
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.13625004
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.99784329
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94359493
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.80482965
6MYC_22102868_ChIP-Seq_BL_Human3.17362875
7VDR_21846776_ChIP-Seq_THP-1_Human2.90123923
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84207621
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.63376092
10RUNX_20019798_ChIP-Seq_JUKART_Human2.51269712
11TCF7_22412390_ChIP-Seq_EML_Mouse2.48931220
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45091787
13* MAF_26560356_Chip-Seq_TH1_Human2.43450022
14E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.43310712
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42636573
16SCL_19346495_ChIP-Seq_HPC-7_Human2.35079070
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.31373122
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28052410
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27773588
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25773406
21MAF_26560356_Chip-Seq_TH2_Human2.23308313
22KDM2B_26808549_Chip-Seq_DND41_Human2.20537198
23UTX_26944678_Chip-Seq_JUKART_Human2.16116850
24ZNF274_21170338_ChIP-Seq_K562_Hela2.15338448
25VDR_24763502_ChIP-Seq_THP-1_Human2.12432935
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.09108257
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.07458054
28MYB_26560356_Chip-Seq_TH2_Human2.06135504
29MYB_26560356_Chip-Seq_TH1_Human2.03934369
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03371189
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.5945731
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99855978
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.94143159
34SPI1_23127762_ChIP-Seq_K562_Human1.92289428
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87830001
36GATA1_19941826_ChIP-Seq_K562_Human1.87549668
37LXR_22292898_ChIP-Seq_THP-1_Human1.85094024
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84872065
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81180507
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.78741175
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.77250286
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76608256
43CIITA_25753668_ChIP-Seq_RAJI_Human1.72097751
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71949112
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65640968
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.62654715
47SMC4_20622854_ChIP-Seq_HELA_Human1.61681754
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.59727657
49GATA3_27048872_Chip-Seq_THYMUS_Human1.58284461
50VDR_22108803_ChIP-Seq_LS180_Human1.58284040
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56868739
52P68_20966046_ChIP-Seq_HELA_Human1.55938642
53CBP_20019798_ChIP-Seq_JUKART_Human1.54564727
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54564727
55GATA1_22025678_ChIP-Seq_K562_Human1.53219811
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52000643
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51711237
58REST_21632747_ChIP-Seq_MESCs_Mouse1.50855032
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.50063333
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.49433844
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47378872
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45604474
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44820430
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.44324319
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44230414
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.42790369
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42572063
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41421602
69NCOR1_26117541_ChIP-Seq_K562_Human1.40332267
70RUNX1_27514584_Chip-Seq_MCF-7_Human1.38810782
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.37699904
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36930023
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36589122
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.36118271
75BCOR_27268052_Chip-Seq_Bcells_Human1.36074954
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34740870
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33580386
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.32942137
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31364451
80GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.29935056
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29437617
82* GATA2_19941826_ChIP-Seq_K562_Human1.29356842
83STAT1_17558387_ChIP-Seq_HELA_Human1.29286037
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28782820
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28272262
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.28175769
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27841260
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.27677250
89FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27287769
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.26727451
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24592818
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24339354
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24339354
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.23794221
95KDM2B_26808549_Chip-Seq_REH_Human1.23712304
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.23323663
97BCL6_27268052_Chip-Seq_Bcells_Human1.23015339
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.22438268
99BCAT_22108803_ChIP-Seq_LS180_Human1.21884726
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20898388
101* TCF4_23295773_ChIP-Seq_U87_Human1.19469048
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18042252
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17653275
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17426638
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16986881
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16859957
107AR_21572438_ChIP-Seq_LNCaP_Human1.16472797
108KDM2B_26808549_Chip-Seq_K562_Human1.16455867
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15513382
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14140962
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.13747097
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.13401494
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12892940
114PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12647746
115VDR_24787735_ChIP-Seq_THP-1_Human1.11280632
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10993645
117RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10946747
118CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09779239
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09512832
120CREB1_26743006_Chip-Seq_LNCaP_Human1.08309324
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07483402
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07162279
123PHF8_20622854_ChIP-Seq_HELA_Human1.07147385
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06725337
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06663368
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.06548756
127MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06219882
128IRF8_21731497_ChIP-ChIP_J774_Mouse1.05660539
129IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05517998
130E2F1_20622854_ChIP-Seq_HELA_Human1.05139306
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04734584
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.04218671
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04085416
134STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03672004
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02979638
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02642832
137TP63_22573176_ChIP-Seq_HFKS_Human1.02348007
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.02082705
139SA1_27219007_Chip-Seq_ERYTHROID_Human1.01442828
140OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00922693
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99139600
142TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99059711
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98825925
144P300_27268052_Chip-Seq_Bcells_Human0.98763653
145GATA3_26560356_Chip-Seq_TH2_Human0.98493637
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98214298
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.98063303
148SPI1_23547873_ChIP-Seq_NB4_Human0.98035325
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.96952300
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96863823
151KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96620491
152CBX2_27304074_Chip-Seq_ESCs_Mouse0.96539553
153* SMAD4_21799915_ChIP-Seq_A2780_Human0.96299152
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.96200479
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95788198
156RACK7_27058665_Chip-Seq_MCF-7_Human0.95251903
157CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94998405
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94864301
159GF1_26923725_Chip-Seq_HPCs_Mouse0.94586035
160P53_22387025_ChIP-Seq_ESCs_Mouse0.94146109
161SOX2_22085726_ChIP-Seq_NPCs_Mouse0.93675006
162RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93591898
163* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.93431402
164P300_18555785_Chip-Seq_ESCs_Mouse0.92355245
165CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92340833
166RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92255830
167OCT4_19829295_ChIP-Seq_ESCs_Human0.91414469
168CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91097976
169STAT3_18555785_Chip-Seq_ESCs_Mouse0.91002721
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90681050
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90394325
172SMAD3_21741376_ChIP-Seq_ESCs_Human0.89718864
173TBL1_22424771_ChIP-Seq_293T_Human0.89429733
174RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88565401
175ER_23166858_ChIP-Seq_MCF-7_Human0.88478236
176DROSHA_22980978_ChIP-Seq_HELA_Human0.88431616
177EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88360686
178RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88272789
179STAT3_23295773_ChIP-Seq_U87_Human0.87433679
180SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86614277
181ESRRB_18555785_Chip-Seq_ESCs_Mouse0.86296886
182PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86272586
183TAF15_26573619_Chip-Seq_HEK293_Human0.86185262
184KLF4_18555785_Chip-Seq_ESCs_Mouse0.85683648
185FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85144123
186CMYC_18555785_Chip-Seq_ESCs_Mouse0.84871205
187GATA3_26560356_Chip-Seq_TH1_Human0.84790772
188MYC_27129775_Chip-Seq_CORNEA_Mouse0.84772754
189SOX2_21211035_ChIP-Seq_LN229_Human0.84456921
190CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84291829
191RNF2_27304074_Chip-Seq_NSC_Mouse0.82013948
192SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81983753
193PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81861366
194PU1_27457419_Chip-Seq_LIVER_Mouse0.81382678
195P53_21459846_ChIP-Seq_SAOS-2_Human0.81069892
196RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80837318
197RUNX1_27457419_Chip-Seq_LIVER_Mouse0.80383263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation6.12361519
2MP0003698_abnormal_male_reproductive5.69514822
3MP0001929_abnormal_gametogenesis5.21082523
4MP0002653_abnormal_ependyma_morphology3.98608475
5MP0002210_abnormal_sex_determination3.78812832
6MP0003763_abnormal_thymus_physiology3.71165878
7MP0001145_abnormal_male_reproductive3.13245124
8MP0003172_abnormal_lysosome_physiology3.08065102
9MP0002161_abnormal_fertility/fecundity3.07168414
10MP0003436_decreased_susceptibility_to3.02196489
11MP0005623_abnormal_meninges_morphology2.97020596
12MP0001800_abnormal_humoral_immune2.72125397
13MP0000653_abnormal_sex_gland2.71069067
14MP0001835_abnormal_antigen_presentation2.60560402
15MP0003303_peritoneal_inflammation2.54212931
16MP0001790_abnormal_immune_system2.28296896
17MP0005387_immune_system_phenotype2.28296896
18MP0000685_abnormal_immune_system2.28088063
19MP0001873_stomach_inflammation2.26089599
20MP0005451_abnormal_body_composition2.24223832
21MP0004381_abnormal_hair_follicle2.19755628
22MP0005076_abnormal_cell_differentiation2.07728165
23MP0002723_abnormal_immune_serum2.04403683
24MP0005410_abnormal_fertilization13.9141486
25MP0003656_abnormal_erythrocyte_physiolo1.95796628
26MP0002398_abnormal_bone_marrow1.93324127
27MP0002396_abnormal_hematopoietic_system1.93270164
28MP0002420_abnormal_adaptive_immunity1.93117224
29MP0001986_abnormal_taste_sensitivity1.92331191
30MP0005670_abnormal_white_adipose1.91298965
31MP0000569_abnormal_digit_pigmentation1.90212894
32MP0002452_abnormal_antigen_presenting1.89698515
33MP0001819_abnormal_immune_cell1.89109703
34MP0005000_abnormal_immune_tolerance1.88676582
35MP0002160_abnormal_reproductive_system1.86546488
36MP0005310_abnormal_salivary_gland1.86162169
37MP0008057_abnormal_DNA_replication1.81093643
38MP0002419_abnormal_innate_immunity1.79848000
39MP0009840_abnormal_foam_cell1.78688636
40MP0000703_abnormal_thymus_morphology1.76729570
41MP0009046_muscle_twitch1.76277813
42MP0002405_respiratory_system_inflammati1.72633708
43MP0000716_abnormal_immune_system1.71724591
44MP0005025_abnormal_response_to1.70594735
45MP0005671_abnormal_response_to1.68912418
46MP0002138_abnormal_hepatobiliary_system1.68302896
47MP0003300_gastrointestinal_ulcer1.58634529
48MP0002009_preneoplasia1.57201856
49MP0000689_abnormal_spleen_morphology1.56492794
50MP0002722_abnormal_immune_system1.56387262
51MP0004947_skin_inflammation1.51052335
52MP0002282_abnormal_trachea_morphology1.48600928
53MP0009115_abnormal_fat_cell1.45080112
54MP0005083_abnormal_biliary_tract1.44879909
55MP0002933_joint_inflammation1.43628663
56MP0010155_abnormal_intestine_physiology1.39800322
57MP0005409_darkened_coat_color1.39789615
58MP0002429_abnormal_blood_cell1.38570291
59MP0001348_abnormal_lacrimal_gland1.37829379
60MP0002132_abnormal_respiratory_system1.36078757
61MP0003646_muscle_fatigue1.34225540
62MP0008260_abnormal_autophagy1.31270654
63MP0005360_urolithiasis1.28360878
64MP0005647_abnormal_sex_gland1.23366659
65MP0003091_abnormal_cell_migration1.22558693
66MP0005464_abnormal_platelet_physiology1.22088872
67MP0002166_altered_tumor_susceptibility1.19094946
68MP0003866_abnormal_defecation1.16442135
69MP0002168_other_aberrant_phenotype1.13551493
70MP0001984_abnormal_olfaction1.13459218
71MP0003724_increased_susceptibility_to1.07511643
72MP0009333_abnormal_splenocyte_physiolog1.04159999
73MP0004510_myositis1.03865249
74MP0003011_delayed_dark_adaptation1.02440300
75MP0003690_abnormal_glial_cell0.98803813
76MP0002998_abnormal_bone_remodeling0.98123764
77MP0000371_diluted_coat_color0.97642261
78MP0001845_abnormal_inflammatory_respons0.97601382
79MP0003828_pulmonary_edema0.97526687
80MP0000609_abnormal_liver_physiology0.94706209
81MP0004233_abnormal_muscle_weight0.93700373
82MP0004134_abnormal_chest_morphology0.93655809
83MP0005174_abnormal_tail_pigmentation0.92147279
84MP0003191_abnormal_cellular_cholesterol0.91678148
85MP0000003_abnormal_adipose_tissue0.91671682
86MP0008995_early_reproductive_senescence0.91036043
87MP0004043_abnormal_pH_regulation0.87445591
88MP0005389_reproductive_system_phenotype0.86062359
89MP0001533_abnormal_skeleton_physiology0.85006174
90MP0008469_abnormal_protein_level0.84930055
91MP0005058_abnormal_lysosome_morphology0.84179062
92MP0003329_amyloid_beta_deposits0.83967130
93MP0001765_abnormal_ion_homeostasis0.83913950
94MP0000249_abnormal_blood_vessel0.83836098
95MP0004808_abnormal_hematopoietic_stem0.81824499
96MP0003045_fibrosis0.78993667
97MP0008058_abnormal_DNA_repair0.77061304
98MP0010094_abnormal_chromosome_stability0.76818363
99MP0009785_altered_susceptibility_to0.76435894
100MP0002118_abnormal_lipid_homeostasis0.76368542
101MP0009278_abnormal_bone_marrow0.75924130
102MP0005334_abnormal_fat_pad0.74812723
103MP0003787_abnormal_imprinting0.74303949
104MP0008007_abnormal_cellular_replicative0.72590173
105MP0004270_analgesia0.71646274
106MP0004859_abnormal_synaptic_plasticity0.71496889
107MP0002019_abnormal_tumor_incidence0.69439084
108MP0003950_abnormal_plasma_membrane0.69349874
109MP0002971_abnormal_brown_adipose0.69157123
110MP0005621_abnormal_cell_physiology0.68883225
111MP0000358_abnormal_cell_content/0.68756511
112MP0005666_abnormal_adipose_tissue0.68018349
113MP0004883_abnormal_blood_vessel0.67940605
114MP0002234_abnormal_pharynx_morphology0.65786448
115MP0003786_premature_aging0.65081309
116MP0002136_abnormal_kidney_physiology0.64563802
117MP0002332_abnormal_exercise_endurance0.63806173
118MP0005551_abnormal_eye_electrophysiolog0.63537911
119MP0005220_abnormal_exocrine_pancreas0.62247183
120MP0005377_hearing/vestibular/ear_phenot0.60802389
121MP0003878_abnormal_ear_physiology0.60802389
122MP0005646_abnormal_pituitary_gland0.56151489
123MP0005397_hematopoietic_system_phenotyp0.54732016
124MP0001545_abnormal_hematopoietic_system0.54732016
125MP0002928_abnormal_bile_duct0.54167601
126MP0005423_abnormal_somatic_nervous0.53687298
127MP0003115_abnormal_respiratory_system0.53572489
128MP0001324_abnormal_eye_pigmentation0.52990521
129MP0005253_abnormal_eye_physiology0.50809123
130MP0008961_abnormal_basal_metabolism0.50122800
131MP0001440_abnormal_grooming_behavior0.49981710
132MP0000604_amyloidosis0.49532013
133MP0002572_abnormal_emotion/affect_behav0.48913601
134MP0004811_abnormal_neuron_physiology0.48702407
135MP0003635_abnormal_synaptic_transmissio0.48203017
136MP0003879_abnormal_hair_cell0.47706865
137MP0000751_myopathy0.46739043
138MP0005391_vision/eye_phenotype0.46188765
139MP0001661_extended_life_span0.45528932
140MP0010307_abnormal_tumor_latency0.44772438
141MP0003699_abnormal_female_reproductive0.44253952
142MP0002152_abnormal_brain_morphology0.43888289
143MP0002909_abnormal_adrenal_gland0.43289940
144MP0000015_abnormal_ear_pigmentation0.42541927
145MP0003633_abnormal_nervous_system0.39758097
146MP0000955_abnormal_spinal_cord0.39477858
147MP0001293_anophthalmia0.38684874
148MP0009745_abnormal_behavioral_response0.37181039
149MP0002063_abnormal_learning/memory/cond0.37058828
150MP0003631_nervous_system_phenotype0.36445794
151MP0004130_abnormal_muscle_cell0.36346707
152MP0002092_abnormal_eye_morphology0.36329927
153MP0002229_neurodegeneration0.34257720
154MP0003861_abnormal_nervous_system0.34241775
155MP0000427_abnormal_hair_cycle0.33241640
156MP0002139_abnormal_hepatobiliary_system0.33170128
157MP0001486_abnormal_startle_reflex0.32745779
158MP0008569_lethality_at_weaning0.32709205
159MP0001851_eye_inflammation0.32471240
160MP0002269_muscular_atrophy0.32059170
161MP0005365_abnormal_bile_salt0.31899225
162MP0002272_abnormal_nervous_system0.31773284
163MP0005375_adipose_tissue_phenotype0.31227797
164MP0001119_abnormal_female_reproductive0.31182371
165MP0002067_abnormal_sensory_capabilities0.31124165
166MP0006072_abnormal_retinal_apoptosis0.31040621
167MP0003634_abnormal_glial_cell0.30142838
168MP0010329_abnormal_lipoprotein_level0.29574831
169MP0009780_abnormal_chondrocyte_physiolo0.29564298
170MP0003252_abnormal_bile_duct0.29130886
171MP0002736_abnormal_nociception_after0.28062325
172MP0003632_abnormal_nervous_system0.27977962
173MP0004019_abnormal_vitamin_homeostasis0.27686885
174MP0002970_abnormal_white_adipose0.27607345
175MP0009703_decreased_birth_body0.27479823
176MP0002064_seizures0.27059318
177MP0005535_abnormal_body_temperature0.26930760

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.03042573
2Abnormal respiratory epithelium morphology (HP:0012253)8.25204655
3Abnormal respiratory motile cilium morphology (HP:0005938)8.25204655
4Rhinitis (HP:0012384)8.05603595
5Abnormal ciliary motility (HP:0012262)7.22076837
6Chronic bronchitis (HP:0004469)6.65092098
7Nasal polyposis (HP:0100582)6.30962447
8Infertility (HP:0000789)5.95063094
9Abnormality of the nasal mucosa (HP:0000433)5.15652395
10Abnormality of the lower motor neuron (HP:0002366)4.75129062
11Abnormality of the fingertips (HP:0001211)4.64644438
12Nephronophthisis (HP:0000090)4.64381128
13Bronchiectasis (HP:0002110)4.60794525
14Bronchitis (HP:0012387)4.34375295
15Colitis (HP:0002583)3.84151349
16Abnormality of the renal medulla (HP:0100957)3.66309130
17Tubulointerstitial nephritis (HP:0001970)3.53052522
18Amyotrophic lateral sclerosis (HP:0007354)3.52553511
19Recurrent otitis media (HP:0000403)3.44213145
20Chronic hepatic failure (HP:0100626)3.32236821
21Gonadotropin excess (HP:0000837)3.29490702
22Fibular hypoplasia (HP:0003038)3.29177162
23Recurrent sinusitis (HP:0011108)3.20114701
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.19263884
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.10612779
26Inflammation of the large intestine (HP:0002037)2.92239887
27Pustule (HP:0200039)2.87939503
28Panhypogammaglobulinemia (HP:0003139)2.87396198
29Eczematoid dermatitis (HP:0000976)2.86356018
30Gastrointestinal inflammation (HP:0004386)2.82511153
31Recurrent bronchitis (HP:0002837)2.80564094
32Upper motor neuron abnormality (HP:0002127)2.78307583
33Hyperkalemia (HP:0002153)2.73450417
34Broad face (HP:0000283)2.70317472
35Recurrent fungal infections (HP:0002841)2.69139578
36Tubulointerstitial abnormality (HP:0001969)2.66683011
37Recurrent cutaneous fungal infections (HP:0011370)2.66504346
38Chronic mucocutaneous candidiasis (HP:0002728)2.66504346
39Impaired proprioception (HP:0010831)2.60669120
40Male infertility (HP:0003251)2.60024423
41Tubular atrophy (HP:0000092)2.59981217
42Gastrointestinal infarctions (HP:0005244)2.49964715
43Recurrent viral infections (HP:0004429)2.46428445
44Hemorrhage of the eye (HP:0011885)2.45086147
45Agammaglobulinemia (HP:0004432)2.44167694
46Absent frontal sinuses (HP:0002688)2.43886975
47Truncal obesity (HP:0001956)2.43488023
48Abnormality of midbrain morphology (HP:0002418)2.41877815
49Molar tooth sign on MRI (HP:0002419)2.41877815
50Genetic anticipation (HP:0003743)2.41707677
51T lymphocytopenia (HP:0005403)2.37728365
52Epistaxis (HP:0000421)2.31381325
53Prolonged bleeding time (HP:0003010)2.31008356
54Gastrointestinal stroma tumor (HP:0100723)2.30975751
55Basal cell carcinoma (HP:0002671)2.29575730
56Dysmetric saccades (HP:0000641)2.29504553
57Increased IgE level (HP:0003212)2.27456653
58Postaxial foot polydactyly (HP:0001830)2.25449922
59Meningitis (HP:0001287)2.24013500
60Papilledema (HP:0001085)2.22912146
61Joint hemorrhage (HP:0005261)2.22141525
62Medial flaring of the eyebrow (HP:0010747)2.20995471
63Abnormality of the anterior horn cell (HP:0006802)2.20912785
64Degeneration of anterior horn cells (HP:0002398)2.20912785
65Stage 5 chronic kidney disease (HP:0003774)2.19874812
66Abnormal spermatogenesis (HP:0008669)2.19126235
67Hypoplasia of the thymus (HP:0000778)2.18859132
68Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16162428
69Myositis (HP:0100614)2.14669540
70Spontaneous hematomas (HP:0007420)2.14599424
71Abnormality of T cell number (HP:0011839)2.10725055
72Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10312808
73Narrow palate (HP:0000189)2.09128546
74Gingival bleeding (HP:0000225)2.08685519
75Impulsivity (HP:0100710)2.07927768
76Aplasia/Hypoplasia of the fibula (HP:0006492)2.07469465
77Gingivitis (HP:0000230)2.07029833
78Recurrent bacterial skin infections (HP:0005406)2.06824537
79Vasculitis (HP:0002633)2.06649561
80Obstructive sleep apnea (HP:0002870)2.06309600
81Hyperlipoproteinemia (HP:0010980)2.04436919
82Short ribs (HP:0000773)2.03878471
83Abnormality of the renal cortex (HP:0011035)2.03502504
84J-shaped sella turcica (HP:0002680)2.03325105
85Dislocated radial head (HP:0003083)2.00926693
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4874213
87Absent/shortened dynein arms (HP:0200106)11.8174675
88Dynein arm defect of respiratory motile cilia (HP:0012255)11.8174675
89Abnormality of T cells (HP:0002843)1.99844739
90Malnutrition (HP:0004395)1.98636583
91Hypochromic anemia (HP:0001931)1.97695787
92Congenital hepatic fibrosis (HP:0002612)1.97171559
93Abnormality of the nasal septum (HP:0000419)1.96126143
94Deep venous thrombosis (HP:0002625)1.96099286
95Abnormality of the common coagulation pathway (HP:0010990)1.95353241
96Prominent nose (HP:0000448)1.95274531
97Microglossia (HP:0000171)1.94581247
98Hepatitis (HP:0012115)1.93254946
99Heterotopia (HP:0002282)1.91349395
100Recurrent gram-negative bacterial infections (HP:0005420)1.90991478
101Abnormality of dentin (HP:0010299)1.89742139
102Emphysema (HP:0002097)1.89698925
103Fatigue (HP:0012378)1.89359241
104Azoospermia (HP:0000027)1.88369640
105Lymphopenia (HP:0001888)1.87058708
106Oculomotor apraxia (HP:0000657)1.86421402
107Tubulointerstitial fibrosis (HP:0005576)1.86264113
108Viral hepatitis (HP:0006562)1.86066764
109Abnormality of T cell physiology (HP:0011840)1.84481417
110Recurrent abscess formation (HP:0002722)1.84376236
111Renal dysplasia (HP:0000110)1.84302342
112Spastic tetraparesis (HP:0001285)1.83474956
113Chronic sinusitis (HP:0011109)1.82739229
114Abnormality of the dental root (HP:0006486)1.81658255
115Taurodontia (HP:0000679)1.81658255
116Abnormality of permanent molar morphology (HP:0011071)1.81658255
117Slow saccadic eye movements (HP:0000514)1.81580231
118Cellulitis (HP:0100658)1.79967246
119Acute myeloid leukemia (HP:0004808)1.79849267
120Bell-shaped thorax (HP:0001591)1.79702747
121Conjunctival telangiectasia (HP:0000524)1.78801964
122Seborrheic dermatitis (HP:0001051)1.78470619
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78078551
124Absent epiphyses (HP:0010577)1.78078551
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76321748
126Abnormality of the radial head (HP:0003995)1.75633832
127Supernumerary spleens (HP:0009799)1.75564582
128Mediastinal lymphadenopathy (HP:0100721)1.75286816
129Chest pain (HP:0100749)1.75268263
130Polydipsia (HP:0001959)1.74662716
131Abnormal drinking behavior (HP:0030082)1.74662716
132Granulocytopenia (HP:0001913)1.73562002
133Recurrent skin infections (HP:0001581)1.73489035
134Decreased motor nerve conduction velocity (HP:0003431)1.71989433
135Elevated erythrocyte sedimentation rate (HP:0003565)1.71961432
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70565837
137Sandal gap (HP:0001852)1.70151506
138Abnormality of macrophages (HP:0004311)1.69921787
139Long eyelashes (HP:0000527)1.69748971
140Abnormality of molar morphology (HP:0011070)1.69375146
141Abnormality of molar (HP:0011077)1.69375146
142Papilloma (HP:0012740)1.69294578
143Verrucae (HP:0200043)1.69294578
144Abnormality of the dental pulp (HP:0006479)1.68284125
145Short thorax (HP:0010306)1.68114264
146Gaze-evoked nystagmus (HP:0000640)1.68111890
14711 pairs of ribs (HP:0000878)1.67180981
148Lip pit (HP:0100267)1.66000470
149Onion bulb formation (HP:0003383)1.64973296
150Optic neuritis (HP:0100653)1.64549210
151Retrobulbar optic neuritis (HP:0100654)1.64549210
152Easy fatigability (HP:0003388)1.64486560
153Abnormality of the hepatic vasculature (HP:0006707)1.63875564
154Chronic otitis media (HP:0000389)1.63865881
155Abnormality of cells of the lymphoid lineage (HP:0012140)1.62189282
156Postaxial hand polydactyly (HP:0001162)1.59730941
157Cerebellar dysplasia (HP:0007033)1.55251340
158Abnormal gallbladder physiology (HP:0012438)1.55101424
159Cholecystitis (HP:0001082)1.55101424
160Median cleft lip (HP:0000161)1.54052712
161Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.53446226
162Pachygyria (HP:0001302)1.51740144
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.51720217
164Abnormality of ocular smooth pursuit (HP:0000617)1.50807940
165Cystic liver disease (HP:0006706)1.50383427
166Facial cleft (HP:0002006)1.49894733
167Broad distal phalanx of finger (HP:0009836)1.46789873
168Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46079685
169Deformed sella turcica (HP:0002681)1.45364320
170Nephropathy (HP:0000112)1.43464637
171Bile duct proliferation (HP:0001408)1.37291613
172Abnormal biliary tract physiology (HP:0012439)1.37291613
173Abnormality of the epiphyses of the hand (HP:0005924)1.36363716
174Short femoral neck (HP:0100864)1.36270651
175Breast carcinoma (HP:0003002)1.35092626
176Abnormality of the vasculature of the conjunctiva (HP:0008054)1.34332646
177Abnormality of renal excretion (HP:0011036)1.34153774
178Type II lissencephaly (HP:0007260)1.32695890
179Difficulty walking (HP:0002355)1.28603845
180Impaired vibratory sensation (HP:0002495)1.28539971
181Hemiparesis (HP:0001269)1.28419309
182Large eyes (HP:0001090)1.27086452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.86395438
2PDK48.86395438
3PDK25.60499903
4PRKD33.75451509
5TESK13.65692263
6PNCK3.33126585
7MAP4K13.04541703
8ICK2.92324579
9WNK42.64299219
10PTK2B2.62018167
11STK392.48521026
12PRPF4B2.30183526
13BLK2.22953029
14BRD42.16820085
15ERN12.11548745
16MAP3K72.06301516
17FGFR41.92473610
18NEK21.87610604
19TYK21.84489168
20MAP3K131.81861086
21MAP3K101.73757128
22TNK21.61265218
23WNK11.59263316
24BTK1.57751978
25FGFR31.55967129
26ZAP701.51990147
27MAPK151.51507881
28JAK11.46066823
29MAP3K141.44894484
30STK381.42625345
31MAP2K31.38883152
32JAK31.35626711
33ITK1.34177697
34PIK3CG1.33029461
35SIK11.28094014
36CDC42BPA1.26529540
37MAPK111.26134873
38CAMK1G1.23701320
39IKBKE1.23029115
40NLK1.22961391
41SYK1.22137522
42TXK1.20694113
43EPHB11.14874378
44TAOK31.12800504
45GRK61.11519592
46TYRO31.08724337
47HIPK21.07794371
48HCK1.06894382
49STK31.04107311
50FES1.03541279
51TEC1.01573429
52TRPM71.00824292
53TBK10.99168049
54PKN20.96830949
55FRK0.95212283
56LCK0.89506561
57MELK0.88702282
58DYRK1B0.88376427
59CCNB10.87307790
60CDK40.86351715
61IRAK40.80833356
62MAPK120.79845770
63BMPR1B0.78723328
64CDC70.78185209
65PDK10.77829102
66PRKAA20.77715374
67EPHA30.76621580
68SIK30.76550232
69RET0.74286828
70IKBKB0.73309651
71PASK0.73132482
72KSR20.72857103
73CHUK0.72642044
74JAK20.71884740
75MAPK70.69627933
76PRKD20.69524033
77MAP3K20.65903211
78SMG10.64473936
79PINK10.63463901
80LYN0.62948160
81SGK4940.61134714
82TTN0.59495565
83MAP3K10.58616166
84MAP2K20.58049416
85KIT0.57911770
86CSF1R0.56937424
87NTRK20.56337641
88MARK30.55566015
89NEK90.55525195
90CDK120.52994321
91RPS6KC10.52521054
92RPS6KL10.52521054
93CDK60.50183553
94CHEK10.49546902
95RPS6KA60.49203294
96MAP3K40.47685856
97LMTK20.47444596
98CAMKK10.47283727
99RPS6KA20.46841239
100TTK0.46791414
101MTOR0.46783662
102ATR0.46472682
103WEE10.41281672
104IRAK10.35885904
105PRKAA10.35494019
106ATM0.34829940
107PAK60.34809320
108MUSK0.33028165
109STK110.30998916
110DYRK30.30097581
111NTRK30.29464544
112PRKCG0.27463807
113RPS6KB10.26966506
114YES10.26270526
115MARK20.25212465
116PDGFRB0.25131082
117PAK20.25067304
118CHEK20.22290233
119RIPK40.21366336
120WNK30.20874346
121CDK30.20872077
122PRKCH0.20166086
123EEF2K0.18789569
124MARK10.17015130
125CSK0.15850741
126PDPK10.15737253
127SGK30.15423808
128CSNK1D0.13685550
129SIK20.13598193
130CAMK1D0.12955819
131RPS6KA30.11678801
132TRIB30.11616758
133FGFR20.11583085
134PRKACB0.11311231
135PRKG10.10962820
136NEK60.10836701
137MAP2K70.10391652
138MAPK80.09616481
139PRKDC0.09594798
140PRKCB0.08943745
141GSK3B0.08559589
142PRKCZ0.08264902
143SGK20.08221999
144PRKCQ0.08105121
145MAPKAPK50.07644753
146STK100.07511660
147MAPK130.07305141
148PRKACG0.07172419
149TAOK10.05701388
150SGK10.05416568
151CDK10.05380501
152MAPK100.05274929
153PAK10.05039658
154EGFR0.03735389
155CDK50.03730682
156MAP2K60.03444962
157SRC0.03052556
158CAMK10.02892339
159PLK10.02619939
160AKT30.02458950
161PLK40.02392916
162PTK60.02154698
163CAMK2A0.01807154
164INSR0.01253163
165CDK20.01001569
166MAPK10.00526480
167MAP2K40.00486162
168SGK2230.00402035

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.93833312
2Pyruvate metabolism_Homo sapiens_hsa006203.91007702
3Vitamin B6 metabolism_Homo sapiens_hsa007503.89813011
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.30192469
5Propanoate metabolism_Homo sapiens_hsa006403.26287833
6Glucagon signaling pathway_Homo sapiens_hsa049223.02581288
7Fatty acid biosynthesis_Homo sapiens_hsa000612.93008600
8Selenocompound metabolism_Homo sapiens_hsa004502.26871090
9Other glycan degradation_Homo sapiens_hsa005112.16188486
10Primary immunodeficiency_Homo sapiens_hsa053402.15825106
11Amphetamine addiction_Homo sapiens_hsa050312.13038188
12Acute myeloid leukemia_Homo sapiens_hsa052212.02921033
13Pentose phosphate pathway_Homo sapiens_hsa000302.02022172
14Glycerolipid metabolism_Homo sapiens_hsa005612.00194339
15Fanconi anemia pathway_Homo sapiens_hsa034601.99770591
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89732752
17Oocyte meiosis_Homo sapiens_hsa041141.87053049
18Renin secretion_Homo sapiens_hsa049241.81696963
19PPAR signaling pathway_Homo sapiens_hsa033201.77794669
20T cell receptor signaling pathway_Homo sapiens_hsa046601.76509450
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70226449
22Linoleic acid metabolism_Homo sapiens_hsa005911.66912243
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66434187
24Basal transcription factors_Homo sapiens_hsa030221.64241966
25Non-small cell lung cancer_Homo sapiens_hsa052231.62061534
26Osteoclast differentiation_Homo sapiens_hsa043801.59574301
27Huntingtons disease_Homo sapiens_hsa050161.57948553
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.55785142
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50982723
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48320909
31Long-term potentiation_Homo sapiens_hsa047201.43244777
32Chronic myeloid leukemia_Homo sapiens_hsa052201.42741606
33Leishmaniasis_Homo sapiens_hsa051401.42076525
34Graft-versus-host disease_Homo sapiens_hsa053321.41123398
35ABC transporters_Homo sapiens_hsa020101.40620379
36Staphylococcus aureus infection_Homo sapiens_hsa051501.40113838
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39476467
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.38961096
39Measles_Homo sapiens_hsa051621.37639283
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.35169307
41Influenza A_Homo sapiens_hsa051641.34974852
42mTOR signaling pathway_Homo sapiens_hsa041501.33086042
43Allograft rejection_Homo sapiens_hsa053301.31966926
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.31843154
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.31359315
46Fatty acid metabolism_Homo sapiens_hsa012121.30760050
47Autoimmune thyroid disease_Homo sapiens_hsa053201.27361270
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25237539
49Toxoplasmosis_Homo sapiens_hsa051451.24269267
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23549668
51Notch signaling pathway_Homo sapiens_hsa043301.19350800
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19157483
53Choline metabolism in cancer_Homo sapiens_hsa052311.18764339
54Herpes simplex infection_Homo sapiens_hsa051681.18465526
55Pancreatic cancer_Homo sapiens_hsa052121.17111200
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17095730
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15331960
58FoxO signaling pathway_Homo sapiens_hsa040681.15101675
59Hepatitis B_Homo sapiens_hsa051611.13248720
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11717506
61Carbon metabolism_Homo sapiens_hsa012001.10984129
62mRNA surveillance pathway_Homo sapiens_hsa030151.07874107
63Fructose and mannose metabolism_Homo sapiens_hsa000511.06846217
64Nitrogen metabolism_Homo sapiens_hsa009101.06684501
65TNF signaling pathway_Homo sapiens_hsa046681.05751376
66Prolactin signaling pathway_Homo sapiens_hsa049171.04511769
67Estrogen signaling pathway_Homo sapiens_hsa049151.03877862
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01851656
69Hepatitis C_Homo sapiens_hsa051600.99725611
70Circadian entrainment_Homo sapiens_hsa047130.97848886
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97793197
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97456835
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.97358688
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97245797
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96601697
76Fatty acid degradation_Homo sapiens_hsa000710.96361864
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.95155345
78Endometrial cancer_Homo sapiens_hsa052130.95143668
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94488363
80Insulin secretion_Homo sapiens_hsa049110.93249288
81Hematopoietic cell lineage_Homo sapiens_hsa046400.93012798
82Calcium signaling pathway_Homo sapiens_hsa040200.91798031
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.91297535
84Platelet activation_Homo sapiens_hsa046110.91218061
85Prostate cancer_Homo sapiens_hsa052150.91028489
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90560739
87Antigen processing and presentation_Homo sapiens_hsa046120.89171822
88Glutamatergic synapse_Homo sapiens_hsa047240.88604148
89ErbB signaling pathway_Homo sapiens_hsa040120.88051634
90Type I diabetes mellitus_Homo sapiens_hsa049400.86263518
91GnRH signaling pathway_Homo sapiens_hsa049120.86200606
92Tuberculosis_Homo sapiens_hsa051520.85967869
93Colorectal cancer_Homo sapiens_hsa052100.85421688
94Circadian rhythm_Homo sapiens_hsa047100.83574926
95Renal cell carcinoma_Homo sapiens_hsa052110.81274154
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80722718
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79464244
98Viral myocarditis_Homo sapiens_hsa054160.78673203
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78267755
100Ether lipid metabolism_Homo sapiens_hsa005650.76576190
101Fat digestion and absorption_Homo sapiens_hsa049750.75838071
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.75539780
103Cardiac muscle contraction_Homo sapiens_hsa042600.75073504
104Synaptic vesicle cycle_Homo sapiens_hsa047210.73884989
105Chemokine signaling pathway_Homo sapiens_hsa040620.72120361
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71715266
107Morphine addiction_Homo sapiens_hsa050320.70302570
108Nicotine addiction_Homo sapiens_hsa050330.67425701
109MAPK signaling pathway_Homo sapiens_hsa040100.67091311
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67081574
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66752350
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66594128
113Apoptosis_Homo sapiens_hsa042100.66051331
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65458181
115Viral carcinogenesis_Homo sapiens_hsa052030.65046695
116Cocaine addiction_Homo sapiens_hsa050300.64976952
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63350048
118Inositol phosphate metabolism_Homo sapiens_hsa005620.62966244
119AMPK signaling pathway_Homo sapiens_hsa041520.62829939
120Gastric acid secretion_Homo sapiens_hsa049710.61360210
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60640139
122Biosynthesis of amino acids_Homo sapiens_hsa012300.60403544
123HTLV-I infection_Homo sapiens_hsa051660.59868098
124VEGF signaling pathway_Homo sapiens_hsa043700.59588303
125Bile secretion_Homo sapiens_hsa049760.59524286
126N-Glycan biosynthesis_Homo sapiens_hsa005100.59197062
127Taste transduction_Homo sapiens_hsa047420.57650499
128Salivary secretion_Homo sapiens_hsa049700.56693486
129Olfactory transduction_Homo sapiens_hsa047400.56656927
130Type II diabetes mellitus_Homo sapiens_hsa049300.56609241
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.56324458
132Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55941413
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.55902090
134Dopaminergic synapse_Homo sapiens_hsa047280.54298474
135Glioma_Homo sapiens_hsa052140.53701164
136RNA transport_Homo sapiens_hsa030130.53018879
137HIF-1 signaling pathway_Homo sapiens_hsa040660.52980521
138cAMP signaling pathway_Homo sapiens_hsa040240.52102940
139B cell receptor signaling pathway_Homo sapiens_hsa046620.51989610
140Asthma_Homo sapiens_hsa053100.51533714
141Small cell lung cancer_Homo sapiens_hsa052220.50602977
142Thyroid hormone synthesis_Homo sapiens_hsa049180.50290651
143Epstein-Barr virus infection_Homo sapiens_hsa051690.46061371
144Oxytocin signaling pathway_Homo sapiens_hsa049210.46006050
145Lysine degradation_Homo sapiens_hsa003100.45858262
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.45728041
147Malaria_Homo sapiens_hsa051440.45010888
148MicroRNAs in cancer_Homo sapiens_hsa052060.43479554
149Endocytosis_Homo sapiens_hsa041440.40765111
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40605543
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.40447586
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39396969
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39142077
154Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38735487
155Complement and coagulation cascades_Homo sapiens_hsa046100.38667220
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37250971
157Purine metabolism_Homo sapiens_hsa002300.36558633
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31118218
159Mineral absorption_Homo sapiens_hsa049780.29776064
160Sphingolipid metabolism_Homo sapiens_hsa006000.29751826
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28566744
162Chemical carcinogenesis_Homo sapiens_hsa052040.28434875
163Insulin resistance_Homo sapiens_hsa049310.28046495
164Wnt signaling pathway_Homo sapiens_hsa043100.27967499
165Hedgehog signaling pathway_Homo sapiens_hsa043400.25672116
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25626415
167Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23367783
168Pancreatic secretion_Homo sapiens_hsa049720.22743874
169Insulin signaling pathway_Homo sapiens_hsa049100.19891560

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