DNM1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.96460653
2synaptic vesicle exocytosis (GO:0016079)5.45427782
3nuclear pore complex assembly (GO:0051292)5.42353833
4synaptic vesicle maturation (GO:0016188)5.28332223
5glutamate secretion (GO:0014047)5.15196674
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.12445741
7nuclear pore organization (GO:0006999)5.11944661
8vocalization behavior (GO:0071625)5.10837506
9regulation of synaptic vesicle exocytosis (GO:2000300)5.10409772
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98542477
11locomotory exploration behavior (GO:0035641)4.97724133
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95033239
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.86608860
14neuron cell-cell adhesion (GO:0007158)4.65738488
15neuronal action potential propagation (GO:0019227)4.65063748
16regulation of glutamate receptor signaling pathway (GO:1900449)4.63303581
17neurotransmitter secretion (GO:0007269)4.54011462
18regulation of synaptic vesicle transport (GO:1902803)4.47211573
19protein localization to synapse (GO:0035418)4.43020635
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.28735040
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.25051900
22pore complex assembly (GO:0046931)4.18983891
23mitotic sister chromatid cohesion (GO:0007064)4.18492229
24synaptic transmission, glutamatergic (GO:0035249)4.06905705
25neuron-neuron synaptic transmission (GO:0007270)4.06647148
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05081947
27exploration behavior (GO:0035640)4.04790830
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.01634215
29layer formation in cerebral cortex (GO:0021819)4.01611089
30proline transport (GO:0015824)3.90710889
31regulation of neuronal synaptic plasticity (GO:0048168)3.90617953
32glutamate receptor signaling pathway (GO:0007215)3.90330998
33neuron recognition (GO:0008038)3.79376686
34positive regulation of synapse maturation (GO:0090129)3.79207879
35gamma-aminobutyric acid transport (GO:0015812)3.77972118
36regulation of synapse structural plasticity (GO:0051823)3.77476631
37axonal fasciculation (GO:0007413)3.75605069
38regulation of centriole replication (GO:0046599)3.72873427
39sister chromatid segregation (GO:0000819)3.69481614
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.68252713
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68239917
42DNA double-strand break processing (GO:0000729)3.67710303
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.64723862
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61910483
45neurotransmitter-gated ion channel clustering (GO:0072578)3.60956428
46neurotransmitter transport (GO:0006836)3.59244009
47dendritic spine morphogenesis (GO:0060997)3.58886222
48mitotic sister chromatid segregation (GO:0000070)3.57079764
49cellular potassium ion homeostasis (GO:0030007)3.54434818
50cerebellar Purkinje cell differentiation (GO:0021702)3.54310122
51membrane depolarization during action potential (GO:0086010)3.49277791
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.47438852
53activation of protein kinase A activity (GO:0034199)3.46792031
54long-term memory (GO:0007616)3.43372641
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.39662271
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38741184
57synaptic vesicle endocytosis (GO:0048488)3.38049083
58regulation of postsynaptic membrane potential (GO:0060078)3.37966132
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34352415
60vesicle transport along microtubule (GO:0047496)3.33756222
61regulation of neurotransmitter secretion (GO:0046928)3.32949375
62regulation of neurotransmitter levels (GO:0001505)3.30441924
63innervation (GO:0060384)3.30204019
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29564635
65positive regulation of membrane potential (GO:0045838)3.29023818
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.27421356
67cell communication by electrical coupling (GO:0010644)3.27204105
68cell migration in hindbrain (GO:0021535)3.24309458
69regulation of synaptic plasticity (GO:0048167)3.23424581
70long-term synaptic potentiation (GO:0060291)3.22478275
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21804053
72regulation of DNA endoreduplication (GO:0032875)3.20716239
73double-strand break repair via nonhomologous end joining (GO:0006303)3.19584003
74non-recombinational repair (GO:0000726)3.19584003
75transmission of nerve impulse (GO:0019226)3.19485152
76sodium ion export (GO:0071436)3.19480521
77cerebellar granule cell differentiation (GO:0021707)3.18620931
78postsynaptic membrane organization (GO:0001941)3.16373067
79regulation of dendritic spine morphogenesis (GO:0061001)3.15972358
80response to histamine (GO:0034776)3.14013944
81neuromuscular process controlling balance (GO:0050885)3.10554525
82regulation of vesicle fusion (GO:0031338)3.10394403
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10357577
84membrane depolarization (GO:0051899)3.09889953
85negative regulation of dendrite morphogenesis (GO:0050774)3.09486516
86behavioral defense response (GO:0002209)3.08412524
87behavioral fear response (GO:0001662)3.08412524
88presynaptic membrane assembly (GO:0097105)3.07984211
89striatum development (GO:0021756)3.06315262
90DNA unwinding involved in DNA replication (GO:0006268)3.06264024
91organelle transport along microtubule (GO:0072384)3.05978609
92regulation of neurotransmitter transport (GO:0051588)3.03193848
93synapse assembly (GO:0007416)3.02281975
94establishment of nucleus localization (GO:0040023)3.02096831
95positive regulation of potassium ion transmembrane transport (GO:1901381)3.01109040
96negative regulation of microtubule polymerization (GO:0031115)3.00696751
97auditory behavior (GO:0031223)3.00336550
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99355208
99membrane hyperpolarization (GO:0060081)2.97474840
100synaptic transmission (GO:0007268)2.96514728
101monoubiquitinated protein deubiquitination (GO:0035520)2.94722239
102neuromuscular process controlling posture (GO:0050884)2.94248164
103negative regulation of DNA recombination (GO:0045910)2.94231915
104prepulse inhibition (GO:0060134)2.92895821
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91940535
106fear response (GO:0042596)2.89977934
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.89826078
108response to auditory stimulus (GO:0010996)2.89749831
109dendrite morphogenesis (GO:0048813)2.89259823
110regulation of synapse maturation (GO:0090128)2.88697158
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88646930
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88508580
113negative regulation of dendrite development (GO:2000171)2.88039117
114positive regulation of neurotransmitter transport (GO:0051590)2.85689563
115synapse organization (GO:0050808)2.84778874
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.84208020
117protein localization to kinetochore (GO:0034501)2.83664097
118DNA replication-dependent nucleosome assembly (GO:0006335)2.80590056
119DNA replication-dependent nucleosome organization (GO:0034723)2.80590056
120regulation of Rac protein signal transduction (GO:0035020)2.72471187
121mitotic spindle checkpoint (GO:0071174)2.70773971
122regulation of sister chromatid cohesion (GO:0007063)2.63988122
123spindle checkpoint (GO:0031577)2.63448560
124regulation of centrosome duplication (GO:0010824)2.63048314
125negative regulation of neurotransmitter secretion (GO:0046929)2.61090295
126regulation of centrosome cycle (GO:0046605)2.60481202
127regulation of sister chromatid segregation (GO:0033045)2.60063065
128regulation of mitotic sister chromatid separation (GO:0010965)2.60063065
129regulation of mitotic sister chromatid segregation (GO:0033047)2.60063065
130regulation of RNA export from nucleus (GO:0046831)2.58061987
131metaphase plate congression (GO:0051310)2.56298966
132negative regulation of chromosome segregation (GO:0051985)2.55770049
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55688150
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55688150
135mitotic spindle assembly checkpoint (GO:0007094)2.55400369
136attachment of spindle microtubules to kinetochore (GO:0008608)2.55371152
137protein localization to chromosome, centromeric region (GO:0071459)2.55321232
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.55122227
139negative regulation of sister chromatid segregation (GO:0033046)2.55122227
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55122227
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.55122227
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55122227
143regulation of chromosome segregation (GO:0051983)2.52548388
144spindle assembly checkpoint (GO:0071173)2.52328398
145negative regulation of neurotransmitter transport (GO:0051589)2.49644669
146mitotic spindle organization (GO:0007052)2.49307175
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.46589681
148centriole replication (GO:0007099)2.45366679
149mitotic nuclear envelope disassembly (GO:0007077)2.44930536
150regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43586124
151ribosome assembly (GO:0042255)2.43463768
152replication fork processing (GO:0031297)2.43357957
153membrane disassembly (GO:0030397)2.41271052
154nuclear envelope disassembly (GO:0051081)2.41271052
155DNA duplex unwinding (GO:0032508)2.40592232
156mitotic metaphase plate congression (GO:0007080)2.39955647
157DNA geometric change (GO:0032392)2.38936160
158histone exchange (GO:0043486)2.38009148
159sister chromatid cohesion (GO:0007062)2.37486263
160regulation of mitotic spindle organization (GO:0060236)2.36904826
161microtubule anchoring (GO:0034453)2.34371624
162regulation of cofactor metabolic process (GO:0051193)2.34169435
163regulation of coenzyme metabolic process (GO:0051196)2.34169435
164kinetochore organization (GO:0051383)2.33613637
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.32973349
166somatic diversification of immune receptors via somatic mutation (GO:0002566)2.32973349
167regulation of acyl-CoA biosynthetic process (GO:0050812)2.32836852
168microtubule polymerization or depolymerization (GO:0031109)2.32465112
169positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.32064387
170positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.32064387
171positive regulation of mitotic sister chromatid separation (GO:1901970)2.32064387
172presynaptic membrane organization (GO:0097090)2.28704065
173chromatin remodeling at centromere (GO:0031055)2.25477518
174positive regulation of chromosome segregation (GO:0051984)2.24023813
175CENP-A containing nucleosome assembly (GO:0034080)2.23146855
176regulation of mRNA splicing, via spliceosome (GO:0048024)2.20221120
177establishment of integrated proviral latency (GO:0075713)2.19401593
178meiotic chromosome segregation (GO:0045132)2.18431838
179microtubule depolymerization (GO:0007019)2.18415660
180central nervous system projection neuron axonogenesis (GO:0021952)2.15509671
181DNA replication checkpoint (GO:0000076)2.14382272
182postreplication repair (GO:0006301)2.14341783
183RNA polyadenylation (GO:0043631)2.14258905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09057943
2E2F7_22180533_ChIP-Seq_HELA_Human4.78684961
3GBX2_23144817_ChIP-Seq_PC3_Human4.00242275
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.88176490
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11179366
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92626371
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.91266827
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82521834
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73751542
10REST_21632747_ChIP-Seq_MESCs_Mouse2.66860955
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.57879012
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.48803842
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46938474
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46938474
15TAF15_26573619_Chip-Seq_HEK293_Human2.41090150
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35449745
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33573116
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33283027
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.31552609
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28176639
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.27043848
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.26016143
23DROSHA_22980978_ChIP-Seq_HELA_Human2.21518852
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19647549
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18845741
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17109486
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14792469
28EWS_26573619_Chip-Seq_HEK293_Human2.08774935
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08642045
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04244833
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.03293910
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99979017
33ELK1_19687146_ChIP-ChIP_HELA_Human1.96208941
34SMAD4_21799915_ChIP-Seq_A2780_Human1.95592636
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.94614631
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93759533
37AR_21572438_ChIP-Seq_LNCaP_Human1.89047271
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85488117
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.84181329
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83771075
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83359993
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83180268
43ZNF274_21170338_ChIP-Seq_K562_Hela1.69958453
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69390095
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67239443
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65048355
47P300_19829295_ChIP-Seq_ESCs_Human1.63166474
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.61387747
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58089952
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.57981412
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57947211
52* AR_21909140_ChIP-Seq_LNCAP_Human1.55789827
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.54052812
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53953253
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51905640
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51759674
57* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50810282
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.50621061
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48730128
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48597821
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48419868
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47753264
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46082230
64STAT3_23295773_ChIP-Seq_U87_Human1.43349279
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43036985
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42469492
67* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40959272
68FUS_26573619_Chip-Seq_HEK293_Human1.39337633
69AR_25329375_ChIP-Seq_VCAP_Human1.39007120
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.38439987
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.38229300
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34305196
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.34045620
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33758142
75AR_19668381_ChIP-Seq_PC3_Human1.33523296
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.30629072
77RNF2_27304074_Chip-Seq_NSC_Mouse1.29066815
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.28761157
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28759542
80IGF1R_20145208_ChIP-Seq_DFB_Human1.28740785
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.28516824
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27689782
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.26173912
84TCF4_23295773_ChIP-Seq_U87_Human1.24773736
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23609501
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22922371
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22663069
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22585354
89* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21821617
90* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21475157
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21319798
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19965166
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.19372317
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19256801
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.18007046
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17312791
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.16097958
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15910680
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.15666898
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14630218
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14117615
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13110240
103AHR_22903824_ChIP-Seq_MCF-7_Human1.11671909
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10064308
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09773942
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.09629885
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08923933
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07486251
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06847287
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06647760
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06461115
112* RUNX2_22187159_ChIP-Seq_PCA_Human1.05727512
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05341895
114JUN_21703547_ChIP-Seq_K562_Human1.04663887
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04561510
116RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04542164
117P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04366722
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04354540
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.03828881
120* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03613034
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03238871
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03237705
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.03097213
124RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02715935
125SOX9_26525672_Chip-Seq_HEART_Mouse1.01997564
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.01694607
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.01065329
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00932627
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00870092
130* CBP_20019798_ChIP-Seq_JUKART_Human0.99762222
131* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99762222
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.99663630
133ER_23166858_ChIP-Seq_MCF-7_Human0.99308859
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.97497570
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.96735591
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96338751
137MYC_18940864_ChIP-ChIP_HL60_Human0.96241323
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96154536
139SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96151765
140VDR_22108803_ChIP-Seq_LS180_Human0.96082897
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95956678
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.95943007
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95223380
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95223380
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95074762
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94882342
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94767149
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94294181
149* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94210275
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93677068
151P53_22387025_ChIP-Seq_ESCs_Mouse0.93574275
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.93231835
153* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93135855
154SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93131764
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92876556
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92838561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69583848
2MP0003880_abnormal_central_pattern4.82229104
3MP0003635_abnormal_synaptic_transmissio3.91930630
4MP0008057_abnormal_DNA_replication3.59860207
5MP0004270_analgesia3.54788624
6MP0009046_muscle_twitch3.28781336
7MP0001968_abnormal_touch/_nociception3.26590647
8MP0009745_abnormal_behavioral_response3.21067760
9MP0002063_abnormal_learning/memory/cond3.14444991
10MP0002064_seizures3.03921459
11MP0002734_abnormal_mechanical_nocicepti2.73896891
12MP0002572_abnormal_emotion/affect_behav2.65724524
13MP0002736_abnormal_nociception_after2.63090792
14MP0010094_abnormal_chromosome_stability2.62871239
15MP0002735_abnormal_chemical_nociception2.60526197
16MP0002272_abnormal_nervous_system2.52716205
17MP0005423_abnormal_somatic_nervous2.39139975
18MP0001486_abnormal_startle_reflex2.19609741
19MP0002822_catalepsy2.18386035
20MP0001440_abnormal_grooming_behavior2.11783304
21MP0002733_abnormal_thermal_nociception2.06794790
22MP0006276_abnormal_autonomic_nervous2.06680355
23* MP0002067_abnormal_sensory_capabilities2.02520809
24MP0008058_abnormal_DNA_repair1.99589604
25MP0001970_abnormal_pain_threshold1.99096643
26MP0001501_abnormal_sleep_pattern1.97969116
27MP0003890_abnormal_embryonic-extraembry1.97665722
28MP0002184_abnormal_innervation1.96321601
29MP0000778_abnormal_nervous_system1.94066720
30MP0003122_maternal_imprinting1.91939869
31MP0005386_behavior/neurological_phenoty1.89355006
32MP0004924_abnormal_behavior1.89355006
33MP0003787_abnormal_imprinting1.89110262
34MP0009780_abnormal_chondrocyte_physiolo1.80202756
35MP0001984_abnormal_olfaction1.78595856
36MP0002102_abnormal_ear_morphology1.76616463
37MP0004957_abnormal_blastocyst_morpholog1.73909718
38MP0010352_gastrointestinal_tract_polyps1.73356170
39MP0008007_abnormal_cellular_replicative1.71203691
40* MP0004811_abnormal_neuron_physiology1.69165584
41MP0008569_lethality_at_weaning1.67833170
42MP0002009_preneoplasia1.67132134
43MP0008932_abnormal_embryonic_tissue1.65269598
44MP0002557_abnormal_social/conspecific_i1.64274898
45MP0004858_abnormal_nervous_system1.60969854
46MP0001529_abnormal_vocalization1.55214628
47MP0005646_abnormal_pituitary_gland1.55158217
48MP0000955_abnormal_spinal_cord1.52343004
49MP0003329_amyloid_beta_deposits1.49693996
50MP0009697_abnormal_copulation1.46845956
51MP0000751_myopathy1.45803394
52MP0003077_abnormal_cell_cycle1.44640234
53MP0003111_abnormal_nucleus_morphology1.40985080
54MP0000569_abnormal_digit_pigmentation1.39970572
55* MP0002882_abnormal_neuron_morphology1.37679433
56MP0004145_abnormal_muscle_electrophysio1.37027687
57MP0002909_abnormal_adrenal_gland1.36955029
58* MP0002066_abnormal_motor_capabilities/c1.36874724
59MP0003123_paternal_imprinting1.28310078
60MP0004142_abnormal_muscle_tone1.28031238
61MP0003879_abnormal_hair_cell1.21503501
62MP0003121_genomic_imprinting1.20424356
63MP0004233_abnormal_muscle_weight1.20351629
64MP0003718_maternal_effect1.20138770
65MP0003693_abnormal_embryo_hatching1.19577695
66* MP0004084_abnormal_cardiac_muscle1.18066225
67* MP0004215_abnormal_myocardial_fiber1.17085512
68* MP0002152_abnormal_brain_morphology1.13906774
69MP0004885_abnormal_endolymph1.12892788
70MP0003941_abnormal_skin_development1.09607165
71MP0003633_abnormal_nervous_system1.09211720
72MP0008872_abnormal_physiological_respon1.07812883
73MP0003283_abnormal_digestive_organ1.07370379
74MP0000516_abnormal_urinary_system1.06615960
75MP0005367_renal/urinary_system_phenotyp1.06615960
76MP0003937_abnormal_limbs/digits/tail_de1.06278719
77MP0001730_embryonic_growth_arrest1.05893399
78MP0001188_hyperpigmentation1.05413973
79MP0001905_abnormal_dopamine_level1.04438463
80MP0005645_abnormal_hypothalamus_physiol1.02475686
81MP0004085_abnormal_heartbeat1.01099987
82MP0002234_abnormal_pharynx_morphology1.00664929
83MP0009672_abnormal_birth_weight0.99903076
84MP0003221_abnormal_cardiomyocyte_apopto0.99424806
85* MP0002084_abnormal_developmental_patter0.99400372
86MP0003631_nervous_system_phenotype0.99384340
87MP0009703_decreased_birth_body0.99253329
88* MP0001697_abnormal_embryo_size0.99249372
89MP0003646_muscle_fatigue0.97830439
90* MP0005380_embryogenesis_phenotype0.96447504
91* MP0001672_abnormal_embryogenesis/_devel0.96447504
92MP0003137_abnormal_impulse_conducting0.94191395
93MP0005623_abnormal_meninges_morphology0.93484637
94MP0010386_abnormal_urinary_bladder0.93229636
95MP0003385_abnormal_body_wall0.93067057
96MP0001502_abnormal_circadian_rhythm0.90985107
97MP0004484_altered_response_of0.90622226
98MP0000579_abnormal_nail_morphology0.90262868
99MP0004147_increased_porphyrin_level0.88631556
100MP0000013_abnormal_adipose_tissue0.88449032
101MP0004197_abnormal_fetal_growth/weight/0.86698033
102MP0003755_abnormal_palate_morphology0.85175679
103MP0008877_abnormal_DNA_methylation0.84679787
104* MP0002088_abnormal_embryonic_growth/wei0.84583716
105MP0005187_abnormal_penis_morphology0.84444761
106MP0010678_abnormal_skin_adnexa0.84130732
107MP0002229_neurodegeneration0.83970502
108MP0010307_abnormal_tumor_latency0.83396650
109MP0000383_abnormal_hair_follicle0.83113299
110* MP0003984_embryonic_growth_retardation0.83112299
111MP0001299_abnormal_eye_distance/0.82989287
112* MP0002085_abnormal_embryonic_tissue0.82072780
113MP0003567_abnormal_fetal_cardiomyocyte0.81356822
114MP0001286_abnormal_eye_development0.81040786
115MP0000427_abnormal_hair_cycle0.80489793
116* MP0002069_abnormal_eating/drinking_beha0.80481717
117MP0003632_abnormal_nervous_system0.80321537
118* MP0000350_abnormal_cell_proliferation0.79792598
119MP0002233_abnormal_nose_morphology0.79467093
120MP0005551_abnormal_eye_electrophysiolog0.78840188
121MP0002081_perinatal_lethality0.78704055
122MP0002876_abnormal_thyroid_physiology0.78132127
123MP0004742_abnormal_vestibular_system0.77797775
124MP0002697_abnormal_eye_size0.76733219
125MP0005248_abnormal_Harderian_gland0.76451126
126MP0002752_abnormal_somatic_nervous0.75305580
127MP0001293_anophthalmia0.75214584
128MP0001177_atelectasis0.74755828
129* MP0003861_abnormal_nervous_system0.72873025
130MP0008874_decreased_physiological_sensi0.71642683
131MP0005394_taste/olfaction_phenotype0.70473980
132MP0005499_abnormal_olfactory_system0.70473980
133MP0000631_abnormal_neuroendocrine_gland0.70402273
134MP0001963_abnormal_hearing_physiology0.70288610
135MP0003634_abnormal_glial_cell0.69413881
136MP0008961_abnormal_basal_metabolism0.68490368
137MP0002653_abnormal_ependyma_morphology0.65206189
138* MP0001943_abnormal_respiration0.63880858
139MP0002751_abnormal_autonomic_nervous0.61615771
140MP0001485_abnormal_pinna_reflex0.61559109
141MP0005535_abnormal_body_temperature0.61118508
142MP0006072_abnormal_retinal_apoptosis0.60996537
143* MP0005620_abnormal_muscle_contractility0.60983182
144MP0000537_abnormal_urethra_morphology0.60475392
145MP0002638_abnormal_pupillary_reflex0.60134942
146* MP0010770_preweaning_lethality0.59037910
147* MP0002082_postnatal_lethality0.59037910
148* MP0010769_abnormal_survival0.58034717
149MP0001348_abnormal_lacrimal_gland0.56390699

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.25656560
2Myokymia (HP:0002411)5.85072525
3Focal seizures (HP:0007359)5.43565056
4Atonic seizures (HP:0010819)4.87015328
5Epileptic encephalopathy (HP:0200134)4.64447704
6Visual hallucinations (HP:0002367)4.57063268
7Febrile seizures (HP:0002373)4.48825851
8Progressive cerebellar ataxia (HP:0002073)4.38179368
9Absence seizures (HP:0002121)4.07637771
10Volvulus (HP:0002580)4.03910574
11Dialeptic seizures (HP:0011146)3.63664821
12Generalized tonic-clonic seizures (HP:0002069)3.56028431
13Broad-based gait (HP:0002136)3.35440363
14Action tremor (HP:0002345)3.30238775
15Hyperventilation (HP:0002883)3.23642308
16Gaze-evoked nystagmus (HP:0000640)3.22061332
17Impaired vibration sensation in the lower limbs (HP:0002166)3.19068532
18Truncal ataxia (HP:0002078)3.10751884
19Poor eye contact (HP:0000817)3.06341293
20Dysdiadochokinesis (HP:0002075)2.96941862
21Urinary bladder sphincter dysfunction (HP:0002839)2.92125535
22Abnormality of the lower motor neuron (HP:0002366)2.87759335
23Insidious onset (HP:0003587)2.86177784
24Termporal pattern (HP:0011008)2.86177784
25Abnormal social behavior (HP:0012433)2.81907681
26Impaired social interactions (HP:0000735)2.81907681
27Abnormality of the astrocytes (HP:0100707)2.80594448
28Astrocytoma (HP:0009592)2.80594448
29Depression (HP:0000716)2.78997784
30Chromsome breakage (HP:0040012)2.78419515
31Glioma (HP:0009733)2.75105315
32Ankle clonus (HP:0011448)2.75017889
33Urinary urgency (HP:0000012)2.73064702
34Scanning speech (HP:0002168)2.70765873
35Amblyopia (HP:0000646)2.70683360
36Ependymoma (HP:0002888)2.69771728
37Abnormal eating behavior (HP:0100738)2.69213706
38Impaired smooth pursuit (HP:0007772)2.67072521
39Papillary thyroid carcinoma (HP:0002895)2.62978954
40Supranuclear gaze palsy (HP:0000605)2.62835510
41Excessive salivation (HP:0003781)2.62287209
42Drooling (HP:0002307)2.62287209
43Dysmetric saccades (HP:0000641)2.60064847
44Medulloblastoma (HP:0002885)2.59969508
45Abnormality of the labia minora (HP:0012880)2.57086279
46Pheochromocytoma (HP:0002666)2.53921612
47Genetic anticipation (HP:0003743)2.53440234
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45375831
49Fair hair (HP:0002286)2.43909815
50Dysmetria (HP:0001310)2.43762550
51Abnormality of ocular smooth pursuit (HP:0000617)2.41875885
52Papilledema (HP:0001085)2.40924220
53Increased nuchal translucency (HP:0010880)2.40455912
54Abnormality of chromosome stability (HP:0003220)2.39979019
55Diplopia (HP:0000651)2.39896289
56Abnormality of binocular vision (HP:0011514)2.39896289
57Failure to thrive in infancy (HP:0001531)2.39110022
58Postural instability (HP:0002172)2.34990102
59Cortical dysplasia (HP:0002539)2.34085589
60Birth length less than 3rd percentile (HP:0003561)2.33876779
61Progressive inability to walk (HP:0002505)2.32075498
62Epileptiform EEG discharges (HP:0011182)2.31801281
63Polyphagia (HP:0002591)2.30538833
64Spastic gait (HP:0002064)2.29954844
65Neuroendocrine neoplasm (HP:0100634)2.25906782
66Amyotrophic lateral sclerosis (HP:0007354)2.23979746
67Anxiety (HP:0000739)2.23809074
68Septate vagina (HP:0001153)2.22332169
69Limb dystonia (HP:0002451)2.21799069
70EEG with generalized epileptiform discharges (HP:0011198)2.20799750
71Fetal akinesia sequence (HP:0001989)2.20550585
72Absent speech (HP:0001344)2.19401364
73Mutism (HP:0002300)2.17660243
74Rhabdomyosarcoma (HP:0002859)2.17385663
75Ventricular fibrillation (HP:0001663)2.17344373
76Bradykinesia (HP:0002067)2.16966092
77Resting tremor (HP:0002322)2.13281395
78Abnormality of the corticospinal tract (HP:0002492)2.12602485
79Skull defect (HP:0001362)2.11139603
80Specific learning disability (HP:0001328)2.10950203
81Hypsarrhythmia (HP:0002521)2.10509687
82Lower limb muscle weakness (HP:0007340)2.08818149
83Thyroid carcinoma (HP:0002890)2.06689756
84Gait imbalance (HP:0002141)2.04902187
85Hemiparesis (HP:0001269)2.03511038
86Protruding tongue (HP:0010808)2.02200626
87Impaired vibratory sensation (HP:0002495)2.00025232
88Hypoventilation (HP:0002791)1.97889463
89Abnormal lung lobation (HP:0002101)1.97238401
90Stereotypic behavior (HP:0000733)1.95846217
91Rectovaginal fistula (HP:0000143)1.94946727
92Rectal fistula (HP:0100590)1.94946727
93Impaired pain sensation (HP:0007328)1.94694658
94Abnormality of pain sensation (HP:0010832)1.94694658
95Gait ataxia (HP:0002066)1.93072952
96Inability to walk (HP:0002540)1.92452203
97Abnormal auditory evoked potentials (HP:0006958)1.92174679
98Hemiplegia (HP:0002301)1.91621685
99Inappropriate behavior (HP:0000719)1.91068945
100Blue irides (HP:0000635)1.90769772
101Shoulder girdle muscle weakness (HP:0003547)1.90495969
102Hyperthyroidism (HP:0000836)1.86182229
103Acute lymphatic leukemia (HP:0006721)1.85629630
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85543062
105Status epilepticus (HP:0002133)1.84736434
106Abnormal hair whorl (HP:0010721)1.83635680
107Central scotoma (HP:0000603)1.82664006
108Clitoromegaly (HP:0000057)1.82351720
109Embryonal renal neoplasm (HP:0011794)1.81990538
110Anteriorly placed anus (HP:0001545)1.81955341
111Neoplasm of the peripheral nervous system (HP:0100007)1.81911402
112Intestinal atresia (HP:0011100)1.81868426
113Incomplete penetrance (HP:0003829)1.80954388
114Cerebral inclusion bodies (HP:0100314)1.80338427
115Hypoplasia of the brainstem (HP:0002365)1.80026833
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80026833
117Aplasia cutis congenita (HP:0001057)1.79047165
118Nephroblastoma (Wilms tumor) (HP:0002667)1.78546814
119Torticollis (HP:0000473)1.77298374
120Genital tract atresia (HP:0001827)1.74832015
121Neoplasm of the small intestine (HP:0100833)1.74575360
122Intention tremor (HP:0002080)1.74570945
123Postural tremor (HP:0002174)1.73331872
124* Pointed chin (HP:0000307)1.73288706
125Generalized hypopigmentation of hair (HP:0011358)1.72720110
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.71845474
127Aplasia/Hypoplasia of the uvula (HP:0010293)1.71689405
128Abnormality of chromosome segregation (HP:0002916)1.71491114
129Congenital primary aphakia (HP:0007707)1.70632002
130Cafe-au-lait spot (HP:0000957)1.70186522
131Focal dystonia (HP:0004373)1.69839726
132Myotonia (HP:0002486)1.69183292
133Biliary tract neoplasm (HP:0100574)1.69144150
134Absent eyebrow (HP:0002223)1.67823358
135Duodenal stenosis (HP:0100867)1.67324424
136Small intestinal stenosis (HP:0012848)1.67324424
137Generalized hypotonia (HP:0001290)1.67146511
138Abnormality of salivation (HP:0100755)1.66982562
139Vaginal atresia (HP:0000148)1.66039135
140Neoplasm of the oral cavity (HP:0100649)1.65846278
141Renal cortical cysts (HP:0000803)1.65791374
142Aqueductal stenosis (HP:0002410)1.65267390
143Lower limb asymmetry (HP:0100559)1.65044360
144CNS hypomyelination (HP:0003429)1.64488659
145Colon cancer (HP:0003003)1.63745178
146Neuroectodermal neoplasm (HP:0030061)1.63166516
147Neuroepithelial neoplasm (HP:0030063)1.63166516
148Nervous tissue neoplasm (HP:0030060)1.63166516
149Meckel diverticulum (HP:0002245)1.62930839
150Bowel diverticulosis (HP:0005222)1.62175292
151Large earlobe (HP:0009748)1.60105073
152Deep philtrum (HP:0002002)1.59584423
153Gastroesophageal reflux (HP:0002020)1.58820543
154Cerebral hypomyelination (HP:0006808)1.58701580
155Submucous cleft hard palate (HP:0000176)1.57428307
156Intestinal fistula (HP:0100819)1.57271616
157Abnormality of the duodenum (HP:0002246)1.56532422
158Spastic diplegia (HP:0001264)1.54855204
159Abnormality of the preputium (HP:0100587)1.54195195
160Sloping forehead (HP:0000340)1.54161800
161Neoplasm of striated muscle (HP:0009728)1.53979065
162Abnormality of the ileum (HP:0001549)1.53489802
163Malignant neoplasm of the central nervous system (HP:0100836)1.52780253
164* Horizontal nystagmus (HP:0000666)1.52740866
165Overlapping toe (HP:0001845)1.52268899
166Micropenis (HP:0000054)1.51811190

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.32609141
2MAP3K43.96726901
3MAP3K93.89096165
4EPHA43.35284602
5MAP2K73.12353069
6MARK12.92232731
7MINK12.90939432
8MAP3K122.62347302
9KSR12.50354767
10CASK2.42201774
11MAP2K42.27219297
12PLK42.23862709
13TRIM282.19856887
14MKNK22.17830317
15MKNK12.08495017
16CDC72.08346622
17PAK62.06334573
18EIF2AK11.96219414
19SRPK11.96167560
20NTRK21.95915423
21WNK31.92893052
22KSR21.87286726
23DAPK21.86267769
24FRK1.82620060
25PNCK1.82417009
26NTRK11.81140420
27TTK1.78174638
28PLK21.72870942
29EIF2AK31.72209314
30WEE11.69916636
31EPHA31.66898538
32BUB11.61638034
33MAP4K21.53630301
34BRSK21.52864631
35NEK11.52031747
36GRK51.44704264
37SIK31.42572476
38DAPK11.41642377
39CAMKK11.39491005
40CDK191.38378215
41LATS21.31875824
42* CDK51.26705804
43STK31.26220216
44MAPK131.23927608
45BRD41.22803653
46RIPK41.14889991
47PRKCG1.13599276
48BCR1.11751834
49PDK31.10844135
50PDK41.10844135
51LATS11.07238678
52UHMK11.05974196
53NUAK11.04409004
54PHKG11.03701397
55PHKG21.03701397
56LMTK21.02859691
57CCNB11.02372040
58STK381.02049107
59ARAF1.01615579
60AKT31.01293723
61RET1.01177521
62PBK1.00778989
63BMPR1B0.99384313
64CDK180.97168065
65PKN10.96141921
66PRKD30.95803529
67CAMKK20.94235131
68PLK10.93022433
69CSNK1G10.92089036
70CSNK1G30.91931801
71CDK140.88683877
72CAMK2A0.88618251
73SGK4940.88079004
74SGK2230.88079004
75MST40.87192837
76CDK150.87014651
77SGK20.85955914
78CDK30.85583767
79TYRO30.85538357
80SIK20.82956400
81CSNK1A1L0.82219914
82MAP3K20.81955443
83PAK30.81775680
84STK38L0.80442992
85FES0.79556180
86FER0.79429163
87ATR0.79125881
88ATM0.78812427
89NEK60.77112867
90STK390.72831287
91CDK11A0.72717712
92SCYL20.71804019
93FGFR20.66411833
94PTK2B0.66271606
95CHEK10.65652562
96DMPK0.65030268
97MAP3K130.64616200
98TNIK0.63778722
99OBSCN0.62828729
100SGK30.62621738
101SGK10.62375922
102ZAK0.62040718
103TSSK60.61844779
104PDK20.61805612
105STK110.61434949
106MAP3K60.60591219
107OXSR10.60546027
108DYRK1A0.60020287
109PRPF4B0.59429948
110CHEK20.59369667
111* CDK10.58956296
112PRKCE0.57448157
113WNK10.56588315
114BRAF0.55541958
115CAMK10.54215857
116NEK20.53965583
117CAMK2B0.53787462
118ALK0.53323700
119RAF10.52383080
120PRKDC0.52301143
121CAMK1D0.48006028
122PLK30.47709460
123EIF2AK20.47627238
124CSNK1G20.47357179
125CDC42BPA0.47214451
126PDK10.45799709
127RPS6KB10.45450382
128RPS6KA30.44705123
129CSNK1D0.44657072
130MAPK100.44540424
131* CDK20.44270089
132MAP2K10.43533904
133ERBB30.43265180
134CAMK1G0.42038787
135CAMK2D0.39920292
136BMPR20.39556028
137ROCK20.37810105
138PRKCZ0.37692590
139PDPK10.37669215
140BRSK10.37158522
141NME10.36194743
142ADRBK10.35170417
143EPHB20.35163489
144PRKCH0.34946297
145CSNK1E0.34784746
146LIMK10.32342895
147PRKCB0.32072533

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83297349
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56441680
3Non-homologous end-joining_Homo sapiens_hsa034502.85547312
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66434099
5GABAergic synapse_Homo sapiens_hsa047272.63047131
6Long-term potentiation_Homo sapiens_hsa047202.61850429
7Olfactory transduction_Homo sapiens_hsa047402.58631033
8Circadian entrainment_Homo sapiens_hsa047132.52742923
9Morphine addiction_Homo sapiens_hsa050322.38132678
10Glutamatergic synapse_Homo sapiens_hsa047242.36844861
11Amphetamine addiction_Homo sapiens_hsa050312.27561549
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24707687
13Mismatch repair_Homo sapiens_hsa034302.21728849
14Dopaminergic synapse_Homo sapiens_hsa047282.18690885
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14959022
16Cell cycle_Homo sapiens_hsa041102.06323527
17RNA transport_Homo sapiens_hsa030132.03737598
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.01819528
19Fanconi anemia pathway_Homo sapiens_hsa034601.99325216
20Collecting duct acid secretion_Homo sapiens_hsa049661.87705467
21Salivary secretion_Homo sapiens_hsa049701.87026069
22Taste transduction_Homo sapiens_hsa047421.86911488
23Insulin secretion_Homo sapiens_hsa049111.82172373
24Basal transcription factors_Homo sapiens_hsa030221.78542924
25Cholinergic synapse_Homo sapiens_hsa047251.76251085
26Gastric acid secretion_Homo sapiens_hsa049711.72583649
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70022767
28Long-term depression_Homo sapiens_hsa047301.69863924
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68930136
30mRNA surveillance pathway_Homo sapiens_hsa030151.67721456
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62180276
32Oxytocin signaling pathway_Homo sapiens_hsa049211.58198978
33Renin secretion_Homo sapiens_hsa049241.58182777
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57280743
35Serotonergic synapse_Homo sapiens_hsa047261.56775281
36Nucleotide excision repair_Homo sapiens_hsa034201.55237717
37Spliceosome_Homo sapiens_hsa030401.50053755
38Calcium signaling pathway_Homo sapiens_hsa040201.48247368
39Homologous recombination_Homo sapiens_hsa034401.48215515
40DNA replication_Homo sapiens_hsa030301.47833300
41GnRH signaling pathway_Homo sapiens_hsa049121.38230320
42RNA degradation_Homo sapiens_hsa030181.35748870
43Cocaine addiction_Homo sapiens_hsa050301.34489742
44Gap junction_Homo sapiens_hsa045401.31120661
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28785563
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28715108
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28608418
48Oocyte meiosis_Homo sapiens_hsa041141.28417042
49Protein export_Homo sapiens_hsa030601.25985815
50Cardiac muscle contraction_Homo sapiens_hsa042601.25237341
51Type II diabetes mellitus_Homo sapiens_hsa049301.21122390
52Vibrio cholerae infection_Homo sapiens_hsa051101.20240310
53cAMP signaling pathway_Homo sapiens_hsa040241.17608123
54Estrogen signaling pathway_Homo sapiens_hsa049151.16315266
55Glioma_Homo sapiens_hsa052141.12140019
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12077059
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08501164
58ErbB signaling pathway_Homo sapiens_hsa040121.07923308
59Axon guidance_Homo sapiens_hsa043601.06454260
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04864010
61Propanoate metabolism_Homo sapiens_hsa006401.00938085
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00768298
63Melanogenesis_Homo sapiens_hsa049161.00261557
64Steroid biosynthesis_Homo sapiens_hsa001000.98867463
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98506807
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93767488
67Dilated cardiomyopathy_Homo sapiens_hsa054140.93537978
68Selenocompound metabolism_Homo sapiens_hsa004500.92855211
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.91559878
70Lysine degradation_Homo sapiens_hsa003100.91476581
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88419229
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86997492
73Vitamin B6 metabolism_Homo sapiens_hsa007500.86005234
74Dorso-ventral axis formation_Homo sapiens_hsa043200.80978054
75p53 signaling pathway_Homo sapiens_hsa041150.79778742
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.78215102
77Phototransduction_Homo sapiens_hsa047440.77697748
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76944016
79Adherens junction_Homo sapiens_hsa045200.76524851
80Pyruvate metabolism_Homo sapiens_hsa006200.75508396
81mTOR signaling pathway_Homo sapiens_hsa041500.74565903
82Glucagon signaling pathway_Homo sapiens_hsa049220.71805472
83Thyroid hormone synthesis_Homo sapiens_hsa049180.70031347
84MAPK signaling pathway_Homo sapiens_hsa040100.69672246
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69519184
86MicroRNAs in cancer_Homo sapiens_hsa052060.68275866
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67887736
88One carbon pool by folate_Homo sapiens_hsa006700.67793769
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67646829
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.66955699
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66453445
92TGF-beta signaling pathway_Homo sapiens_hsa043500.66153567
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65892669
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65502608
95Purine metabolism_Homo sapiens_hsa002300.65443234
96Choline metabolism in cancer_Homo sapiens_hsa052310.65076377
97Base excision repair_Homo sapiens_hsa034100.64797421
98Biosynthesis of amino acids_Homo sapiens_hsa012300.64583189
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63362953
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60415689
101Endometrial cancer_Homo sapiens_hsa052130.59260396
102Alzheimers disease_Homo sapiens_hsa050100.58641734
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58585578
104Proteasome_Homo sapiens_hsa030500.58544437
105Oxidative phosphorylation_Homo sapiens_hsa001900.58024163
106Alcoholism_Homo sapiens_hsa050340.57467872
107Insulin signaling pathway_Homo sapiens_hsa049100.57139289
108Pancreatic secretion_Homo sapiens_hsa049720.56852255
109Fatty acid metabolism_Homo sapiens_hsa012120.56572173
110Carbon metabolism_Homo sapiens_hsa012000.56232732
111RNA polymerase_Homo sapiens_hsa030200.54862048
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54097507
113Type I diabetes mellitus_Homo sapiens_hsa049400.53397134
114Ras signaling pathway_Homo sapiens_hsa040140.53226589
115Tight junction_Homo sapiens_hsa045300.52782001
116Fatty acid biosynthesis_Homo sapiens_hsa000610.51885605
117Colorectal cancer_Homo sapiens_hsa052100.51863036
118VEGF signaling pathway_Homo sapiens_hsa043700.51047431
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50934365
120Rap1 signaling pathway_Homo sapiens_hsa040150.49808221
121Nitrogen metabolism_Homo sapiens_hsa009100.49635805
122Wnt signaling pathway_Homo sapiens_hsa043100.49550659
123Inositol phosphate metabolism_Homo sapiens_hsa005620.49383260
124Parkinsons disease_Homo sapiens_hsa050120.48669449
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.48287369
126Renal cell carcinoma_Homo sapiens_hsa052110.46547599
127Circadian rhythm_Homo sapiens_hsa047100.44055843
128Butanoate metabolism_Homo sapiens_hsa006500.42951821
129Non-small cell lung cancer_Homo sapiens_hsa052230.41886267
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41571096
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41443670
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39676493
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.39018837
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38831249
135Endocytosis_Homo sapiens_hsa041440.38476979
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36258460
137Huntingtons disease_Homo sapiens_hsa050160.35786566
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34902160
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34402116
140Melanoma_Homo sapiens_hsa052180.30833218
141Hippo signaling pathway_Homo sapiens_hsa043900.30342718
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29861362
143Hedgehog signaling pathway_Homo sapiens_hsa043400.29647633

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