ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glycine transport (GO:0015816)	5.64282928
2	cytoplasmic mRNA processing body assembly (GO:0033962)	5.16621081
3	behavioral response to nicotine (GO:0035095)	5.07407898
4	tachykinin receptor signaling pathway (GO:0007217)	4.96261429
5	positive regulation of mitochondrial fission (GO:0090141)	4.88015543
6	spermatid development (GO:0007286)	4.77608577
7	regulation of female gonad development (GO:2000194)	4.69707417
8	negative regulation of cAMP-mediated signaling (GO:0043951)	4.67460372
9	positive regulation of granulocyte differentiation (GO:0030854)	4.55026473
10	serotonin metabolic process (GO:0042428)	4.48983186
11	detection of light stimulus involved in sensory perception (GO:0050962)	4.29773311
12	detection of light stimulus involved in visual perception (GO:0050908)	4.29773311
13	urinary tract smooth muscle contraction (GO:0014848)	4.25046571
14	primary amino compound metabolic process (GO:1901160)	4.15632576
15	neuronal action potential (GO:0019228)	4.14918454
16	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.99921708
17	phosphate ion transport (GO:0006817)	3.99727725
18	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.99247152
19	microtubule severing (GO:0051013)	3.96747199
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.92846058
21	postsynaptic membrane organization (GO:0001941)	3.87360774
22	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.85909935
23	multicellular organism reproduction (GO:0032504)	3.80827693
24	positive regulation of developmental pigmentation (GO:0048087)	3.78129000
25	piRNA metabolic process (GO:0034587)	3.77586717
26	indole-containing compound metabolic process (GO:0042430)	3.75296499
27	regulation of hippo signaling (GO:0035330)	3.74785383
28	retinal cone cell development (GO:0046549)	3.73152756
29	DNA methylation involved in gamete generation (GO:0043046)	3.72303932
30	negative regulation of protein localization to cell surface (GO:2000009)	3.68375622
31	mitotic cell cycle arrest (GO:0071850)	3.67002088
32	regulation of mitochondrial fission (GO:0090140)	3.66643453
33	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.66371302
34	nerve growth factor signaling pathway (GO:0038180)	3.65156552
35	membrane depolarization during action potential (GO:0086010)	3.63127173
36	histone H2A acetylation (GO:0043968)	3.54461069
37	gene silencing by RNA (GO:0031047)	3.54173476
38	gamma-aminobutyric acid transport (GO:0015812)	3.48835972
39	regulation of pigment cell differentiation (GO:0050932)	3.48292323
40	peristalsis (GO:0030432)	3.42295697
41	transmission of nerve impulse (GO:0019226)	3.37298691
42	chromatin silencing (GO:0006342)	3.35661689
43	positive regulation of heat generation (GO:0031652)	3.33608198
44	gene silencing (GO:0016458)	3.30372698
45	positive regulation of CREB transcription factor activity (GO:0032793)	3.27969624
46	regulation of action potential (GO:0098900)	3.19462176
47	embryonic digestive tract development (GO:0048566)	3.18876406
48	DNA methylation (GO:0006306)	3.16230730
49	DNA alkylation (GO:0006305)	3.16230730
50	neutrophil mediated immunity (GO:0002446)	3.14030039
51	acrosome reaction (GO:0007340)	3.10289558
52	sperm motility (GO:0030317)	3.10145645
53	phosphorelay signal transduction system (GO:0000160)	3.06021262
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03542507
55	photoreceptor cell maintenance (GO:0045494)	3.01252159
56	neuromuscular synaptic transmission (GO:0007274)	3.00873472
57	phosphate ion transmembrane transport (GO:0035435)	2.98414278
58	negative regulation of gene expression, epigenetic (GO:0045814)	2.98256925
59	protein localization to synapse (GO:0035418)	2.95926595
60	opioid receptor signaling pathway (GO:0038003)	2.92934221
61	sensory perception of taste (GO:0050909)	2.91726168
62	cellular ketone body metabolic process (GO:0046950)	2.87396800
63	succinate metabolic process (GO:0006105)	2.86763735
64	behavioral response to pain (GO:0048266)	2.84511612
65	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.83270466
66	microtubule nucleation (GO:0007020)	2.82463329
67	regulation of histone H3-K9 methylation (GO:0051570)	2.82089523
68	ovulation cycle (GO:0042698)	2.80431216
69	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.80342741
70	histone H4-K12 acetylation (GO:0043983)	2.79107972
71	regulation of uterine smooth muscle contraction (GO:0070472)	2.78567211
72	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	2.78294158
73	positive regulation of protein homooligomerization (GO:0032464)	2.77653009
74	regulation of skeletal muscle contraction (GO:0014819)	2.76180174
75	negative regulation of cell aging (GO:0090344)	2.74763497
76	dendritic spine morphogenesis (GO:0060997)	2.70383731
77	protein K6-linked ubiquitination (GO:0085020)	2.70361340
78	regulation of granulocyte differentiation (GO:0030852)	2.70238201
79	germ cell development (GO:0007281)	2.69760732
80	positive regulation of action potential (GO:0045760)	2.69116138
81	positive regulation of microtubule polymerization (GO:0031116)	2.69061591
82	sulfation (GO:0051923)	2.68050122
83	reproduction (GO:0000003)	2.66988040
84	regulation of heat generation (GO:0031650)	2.66637600
85	glomerular visceral epithelial cell development (GO:0072015)	2.66074785
86	protein K48-linked deubiquitination (GO:0071108)	2.64675116
87	protein K63-linked deubiquitination (GO:0070536)	2.62029994
88	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.59599289
89	positive regulation of B cell differentiation (GO:0045579)	2.57891880
90	positive regulation of phosphatase activity (GO:0010922)	2.57447031
91	regulation of acrosome reaction (GO:0060046)	2.57050530
92	regulation of germinal center formation (GO:0002634)	2.53092597
93	seminiferous tubule development (GO:0072520)	2.51321131
94	response to magnesium ion (GO:0032026)	2.51314985
95	activated T cell proliferation (GO:0050798)	2.49090602
96	regulation of membrane depolarization (GO:0003254)	2.48466193
97	meiosis I (GO:0007127)	2.46966178
98	response to pheromone (GO:0019236)	2.46338381
99	ketone body metabolic process (GO:1902224)	2.44342502
100	response to nerve growth factor (GO:1990089)	2.42256084

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.88802000
2	GATA1_22025678_ChIP-Seq_K562_Human	5.65397204
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.11080240
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.93805522
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.74465765
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.63309597
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.36146115
8	VDR_22108803_ChIP-Seq_LS180_Human	2.35246990
9	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.25830517
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.09494405
11	REST_21632747_ChIP-Seq_MESCs_Mouse	1.75438252
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67971799
13	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62675656
14	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.60195596
15	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.51988395
16	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42957540
17	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.42723093
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36920927
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36920927
20	RXR_22108803_ChIP-Seq_LS180_Human	1.36509421
21	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.36010712
22	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35481285
23	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.35364382
24	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.33656471
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32138920
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31750007
27	RAC3_21632823_ChIP-Seq_H3396_Human	1.29704730
28	STAT3_23295773_ChIP-Seq_U87_Human	1.28052807
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.27568379
30	TCF4_23295773_ChIP-Seq_U87_Human	1.26986450
31	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.26841436
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25863123
33	BCL6_27268052_Chip-Seq_Bcells_Human	1.24921522
34	OCT4_20526341_ChIP-Seq_ESCs_Human	1.23802302
35	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20415738
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.19452897
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.18339044
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17707935
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.17618068
40	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.17017357
41	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16841030
42	AR_25329375_ChIP-Seq_VCAP_Human	1.16430386
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.16339864
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16327913
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.15454564
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15023588
47	MYC_19829295_ChIP-Seq_ESCs_Human	1.14892853
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13906088
49	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.13770546
50	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13600377
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13231759
52	ERA_21632823_ChIP-Seq_H3396_Human	1.12877159
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11887970
54	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.11574131
55	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.11519100
56	NCOR_22424771_ChIP-Seq_293T_Human	1.11170441
57	CTCF_27219007_Chip-Seq_Bcells_Human	1.10759879
58	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.10754243
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09869334
60	E2F1_20622854_ChIP-Seq_HELA_Human	1.08937511
61	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.08704397
62	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.06867618
63	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05314176
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.05192004
65	CBP_20019798_ChIP-Seq_JUKART_Human	1.05192004
66	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.04091574
67	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03759852
68	BCOR_27268052_Chip-Seq_Bcells_Human	1.03548647
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.02758538
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02114497
71	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.01616657
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00465557
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.00125738
74	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.00009020
75	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99689922
76	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99176128
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98272296
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98005317
79	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96244546
80	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.96089245
81	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96045642
82	ER_23166858_ChIP-Seq_MCF-7_Human	0.94648078
83	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.94617654
84	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94375040
85	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.94375040
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.94289807
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.93991812
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.93831620
89	PHF8_20622854_ChIP-Seq_HELA_Human	0.93689975
90	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.93465034
91	FUS_26573619_Chip-Seq_HEK293_Human	0.93386755
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92894779
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92784856
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91710512
95	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.91383752
96	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.91280197
97	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.91275788
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91075903
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91075903
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90292180

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002735_abnormal_chemical_nociception	3.64216692
2	MP0008995_early_reproductive_senescence	3.47470592
3	MP0008877_abnormal_DNA_methylation	3.33270644
4	MP0001501_abnormal_sleep_pattern	3.21292388
5	MP0003136_yellow_coat_color	3.11344948
6	MP0002822_catalepsy	3.05698649
7	MP0001968_abnormal_touch/_nociception	2.96914046
8	MP0005410_abnormal_fertilization	2.83790942
9	MP0002736_abnormal_nociception_after	2.67087010
10	MP0005645_abnormal_hypothalamus_physiol	2.61999398
11	MP0002733_abnormal_thermal_nociception	2.54816322
12	MP0001986_abnormal_taste_sensitivity	2.54208145
13	MP0006276_abnormal_autonomic_nervous	2.40596082
14	MP0005423_abnormal_somatic_nervous	2.21829403
15	MP0005551_abnormal_eye_electrophysiolog	2.19384447
16	MP0001873_stomach_inflammation	2.14774201
17	MP0009046_muscle_twitch	2.08675607
18	MP0001970_abnormal_pain_threshold	1.96756712
19	MP0003878_abnormal_ear_physiology	1.93245502
20	MP0005377_hearing/vestibular/ear_phenot	1.93245502
21	MP0004142_abnormal_muscle_tone	1.76476793
22	MP0005171_absent_coat_pigmentation	1.75850007
23	MP0001929_abnormal_gametogenesis	1.75223205
24	MP0003635_abnormal_synaptic_transmissio	1.72814605
25	MP0005397_hematopoietic_system_phenotyp	1.71101654
26	MP0001545_abnormal_hematopoietic_system	1.71101654
27	MP0009745_abnormal_behavioral_response	1.70840175
28	MP0003879_abnormal_hair_cell	1.70026598
29	MP0002272_abnormal_nervous_system	1.68578969
30	MP0000569_abnormal_digit_pigmentation	1.65869357
31	MP0003718_maternal_effect	1.63437836
32	MP0002332_abnormal_exercise_endurance	1.62549583
33	MP0005083_abnormal_biliary_tract	1.62122232
34	MP0004130_abnormal_muscle_cell	1.61473382
35	MP0003698_abnormal_male_reproductive	1.56189880
36	MP0002572_abnormal_emotion/affect_behav	1.54433730
37	MP0000013_abnormal_adipose_tissue	1.54350412
38	MP0004859_abnormal_synaptic_plasticity	1.51874859
39	MP0003646_muscle_fatigue	1.47010572
40	MP0001486_abnormal_startle_reflex	1.45986400
41	MP0001664_abnormal_digestion	1.42986080
42	MP0010386_abnormal_urinary_bladder	1.41083579
43	MP0009384_cardiac_valve_regurgitation	1.37807271
44	MP0002063_abnormal_learning/memory/cond	1.36846580
45	MP0000566_synostosis	1.33582253
46	MP0000631_abnormal_neuroendocrine_gland	1.33008199
47	MP0001348_abnormal_lacrimal_gland	1.32513265
48	MP0002064_seizures	1.30797014
49	MP0001502_abnormal_circadian_rhythm	1.28123378
50	MP0002210_abnormal_sex_determination	1.24645517
51	MP0001485_abnormal_pinna_reflex	1.24260565
52	MP0002067_abnormal_sensory_capabilities	1.23070885
53	MP0000427_abnormal_hair_cycle	1.22757307
54	MP0005535_abnormal_body_temperature	1.20264833
55	MP0002638_abnormal_pupillary_reflex	1.18224725
56	MP0000372_irregular_coat_pigmentation	1.18127895
57	MP0009278_abnormal_bone_marrow	1.17628990
58	MP0005253_abnormal_eye_physiology	1.12318212
59	MP0005266_abnormal_metabolism	1.11118790
60	MP0003045_fibrosis	1.10436192
61	MP0003868_abnormal_feces_composition	1.08483040
62	MP0002161_abnormal_fertility/fecundity	1.04388997
63	MP0004043_abnormal_pH_regulation	1.02377836
64	MP0003959_abnormal_lean_body	1.00943739
65	MP0002653_abnormal_ependyma_morphology	1.00818584
66	MP0003195_calcinosis	1.00705157
67	MP0006138_congestive_heart_failure	0.98798954
68	MP0000383_abnormal_hair_follicle	0.97599018
69	MP0001145_abnormal_male_reproductive	0.96336802
70	MP0004145_abnormal_muscle_electrophysio	0.93716852
71	MP0003656_abnormal_erythrocyte_physiolo	0.93078466
72	MP0004924_abnormal_behavior	0.92562774
73	MP0005386_behavior/neurological_phenoty	0.92562774
74	MP0000653_abnormal_sex_gland	0.91350100
75	MP0005448_abnormal_energy_balance	0.89719031
76	MP0004019_abnormal_vitamin_homeostasis	0.87658147
77	MP0001963_abnormal_hearing_physiology	0.87146286
78	MP0004085_abnormal_heartbeat	0.86060452
79	MP0001765_abnormal_ion_homeostasis	0.85570528
80	MP0000538_abnormal_urinary_bladder	0.83570999
81	MP0002102_abnormal_ear_morphology	0.79803416
82	MP0008872_abnormal_physiological_respon	0.79697449
83	MP0001764_abnormal_homeostasis	0.79435699
84	MP0002229_neurodegeneration	0.78480561
85	MP0002160_abnormal_reproductive_system	0.77469385
86	MP0005409_darkened_coat_color	0.76711188
87	MP0005334_abnormal_fat_pad	0.75550448
88	MP0003880_abnormal_central_pattern	0.75257081
89	MP0006292_abnormal_olfactory_placode	0.75247816
90	MP0005647_abnormal_sex_gland	0.75240487
91	MP0004147_increased_porphyrin_level	0.74366347
92	MP0002557_abnormal_social/conspecific_i	0.73851548
93	MP0001905_abnormal_dopamine_level	0.72957812
94	MP0005646_abnormal_pituitary_gland	0.72810749
95	MP0004215_abnormal_myocardial_fiber	0.71911259
96	MP0000470_abnormal_stomach_morphology	0.69073438
97	MP0008775_abnormal_heart_ventricle	0.66989473
98	MP0000230_abnormal_systemic_arterial	0.65846475
99	MP0004133_heterotaxia	0.65173596
100	MP0003953_abnormal_hormone_level	0.65057373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	8.69998966
2	Attenuation of retinal blood vessels (HP:0007843)	5.50200321
3	Pendular nystagmus (HP:0012043)	4.95248226
4	Decreased central vision (HP:0007663)	4.65828836
5	Severe visual impairment (HP:0001141)	4.60313322
6	Genetic anticipation (HP:0003743)	4.54127758
7	Congenital stationary night blindness (HP:0007642)	4.15440505
8	Generalized aminoaciduria (HP:0002909)	4.05138565
9	Bony spicule pigmentary retinopathy (HP:0007737)	3.99838277
10	Proximal tubulopathy (HP:0000114)	3.77311927
11	Pancreatic cysts (HP:0001737)	3.32877407
12	Abolished electroretinogram (ERG) (HP:0000550)	3.29184069
13	Optic nerve hypoplasia (HP:0000609)	3.21568060
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.19593378
15	Pancreatic fibrosis (HP:0100732)	3.18542420
16	Decreased circulating renin level (HP:0003351)	3.10380537
17	Cystic liver disease (HP:0006706)	3.04440654
18	Methylmalonic aciduria (HP:0012120)	2.95383373
19	Keratoconus (HP:0000563)	2.89622978
20	Increased corneal curvature (HP:0100692)	2.89622978
21	True hermaphroditism (HP:0010459)	2.84667146
22	Progressive cerebellar ataxia (HP:0002073)	2.84101889
23	Aplasia of the musculature (HP:0100854)	2.65366902
24	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.63256193
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.62989221
26	Epidermoid cyst (HP:0200040)	2.51735842
27	Chronic hepatic failure (HP:0100626)	2.48666454
28	Supernumerary spleens (HP:0009799)	2.46316103
29	Abnormality of midbrain morphology (HP:0002418)	2.39724664
30	Molar tooth sign on MRI (HP:0002419)	2.39724664
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.39666510
32	Fetal akinesia sequence (HP:0001989)	2.36828067
33	Long clavicles (HP:0000890)	2.34404675
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32951386
35	Abnormality of alanine metabolism (HP:0010916)	2.32951386
36	Hyperalaninemia (HP:0003348)	2.32951386
37	Enlarged epiphyses (HP:0010580)	2.32754228
38	Congenital sensorineural hearing impairment (HP:0008527)	2.32354194
39	Absent speech (HP:0001344)	2.32189563
40	Mesangial abnormality (HP:0001966)	2.31892249
41	Patellar aplasia (HP:0006443)	2.30070881
42	Facial hemangioma (HP:0000329)	2.28237353
43	Gaze-evoked nystagmus (HP:0000640)	2.27338611
44	Intestinal atresia (HP:0011100)	2.23349379
45	Abnormality of the left ventricular outflow tract (HP:0011103)	2.19066200
46	Subaortic stenosis (HP:0001682)	2.19066200
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.18667244
48	Congenital hepatic fibrosis (HP:0002612)	2.17487206
49	Cerebral palsy (HP:0100021)	2.16565454
50	Macular degeneration (HP:0000608)	2.14771297
51	Intellectual disability, severe (HP:0010864)	2.14026791
52	Unsteady gait (HP:0002317)	2.13111292
53	Hyperlipoproteinemia (HP:0010980)	2.10203902
54	Clumsiness (HP:0002312)	2.09591443
55	Facial diplegia (HP:0001349)	2.07013314
56	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.04578385
57	Polydipsia (HP:0001959)	2.03831729
58	Abnormal drinking behavior (HP:0030082)	2.03831729
59	Bile duct proliferation (HP:0001408)	2.00661277
60	Abnormal biliary tract physiology (HP:0012439)	2.00661277
61	Intellectual disability, progressive (HP:0006887)	1.99685044
62	Abnormality of urine glucose concentration (HP:0011016)	1.97717930
63	Glycosuria (HP:0003076)	1.97717930
64	Epileptic encephalopathy (HP:0200134)	1.96308077
65	Popliteal pterygium (HP:0009756)	1.91949643
66	Myokymia (HP:0002411)	1.91836257
67	Protruding tongue (HP:0010808)	1.91284372
68	Facial shape deformation (HP:0011334)	1.90078764
69	Potter facies (HP:0002009)	1.90078764
70	Tubular atrophy (HP:0000092)	1.89638546
71	Absence seizures (HP:0002121)	1.89180274
72	Intellectual disability, moderate (HP:0002342)	1.87548688
73	Hyperkalemia (HP:0002153)	1.84892635
74	Retinal dysplasia (HP:0007973)	1.81305061
75	Tubulointerstitial fibrosis (HP:0005576)	1.79961256
76	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.79545415
77	Nonprogressive disorder (HP:0003680)	1.78581660
78	Focal seizures (HP:0007359)	1.74838858
79	Dialeptic seizures (HP:0011146)	1.74015788
80	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.73484025
81	Abnormality of the columella (HP:0009929)	1.72895505
82	Anencephaly (HP:0002323)	1.72783596
83	Anterior segment dysgenesis (HP:0007700)	1.72353346
84	Truncal obesity (HP:0001956)	1.72133907
85	Hypophosphatemia (HP:0002148)	1.71511923
86	Premature ovarian failure (HP:0008209)	1.71093145
87	Dyschromatopsia (HP:0007641)	1.70606598
88	Hypoplasia of the pons (HP:0012110)	1.70598574
89	Abnormal ciliary motility (HP:0012262)	1.69168070
90	Postaxial foot polydactyly (HP:0001830)	1.68566043
91	Rib fusion (HP:0000902)	1.68146353
92	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68024477
93	Lip pit (HP:0100267)	1.67964823
94	Atonic seizures (HP:0010819)	1.67308148
95	Photophobia (HP:0000613)	1.66210698
96	Nephronophthisis (HP:0000090)	1.65487776
97	Hypopigmentation of the fundus (HP:0007894)	1.65263638
98	Sclerocornea (HP:0000647)	1.64985329
99	Abnormality of the pons (HP:0007361)	1.64609897
100	Polyuria (HP:0000103)	1.63050822

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.23753257
2	EPHA3	4.10220063
3	CASK	3.43495305
4	MAP3K4	2.88791496
5	CDK12	2.61102275
6	CDK8	2.56262128
7	ADRBK2	2.09041761
8	INSRR	1.99304937
9	MAPK15	1.95186400
10	MARK1	1.95067733
11	DYRK1B	1.89117968
12	ICK	1.72439605
13	CDK19	1.71915707
14	MAP3K7	1.71106538
15	DAPK2	1.62267469
16	PKN1	1.51373896
17	GRK7	1.49699867
18	MAP2K7	1.45047177
19	TNK2	1.42032422
20	TXK	1.40001436
21	MAP4K1	1.35985731
22	PRKD3	1.33946650
23	MOS	1.33616056
24	KDR	1.26290628
25	GRK5	1.20038527
26	BLK	1.18374493
27	EPHB1	1.16005672
28	MAPK13	1.14996465
29	NUAK1	1.10106437
30	BMPR1B	1.08479394
31	CSNK1A1L	1.06584166
32	BRD4	1.05481278
33	AURKA	1.04028563
34	IRAK1	0.99397849
35	CAMK1	0.91658750
36	CSNK1G3	0.89337485
37	CAMK2A	0.88244331
38	ARAF	0.86555590
39	CSNK1G2	0.86009821
40	RPS6KA6	0.85058536
41	MARK2	0.84913400
42	TAOK3	0.83649152
43	TGFBR2	0.83337406
44	ERBB4	0.79880358
45	PRKCG	0.78444416
46	ADRBK1	0.75973147
47	PDK1	0.72801962
48	PRKAA1	0.70550529
49	ACVR1B	0.70499482
50	BCKDK	0.68077725
51	NEK6	0.67494203
52	CAMK4	0.65527861
53	UHMK1	0.64910043
54	STK38	0.62907039
55	SIK2	0.62479894
56	MELK	0.60841843
57	NTRK2	0.59103903
58	SYK	0.58472650
59	DDR2	0.58170016
60	DYRK3	0.57011615
61	CDK3	0.56145600
62	PRKD2	0.55838956
63	EPHA4	0.55798775
64	PRKCH	0.54566073
65	PRKCZ	0.54460329
66	CSNK1D	0.53902901
67	PIM2	0.53660120
68	RPS6KC1	0.53220778
69	RPS6KL1	0.53220778
70	MUSK	0.53150912
71	WNK4	0.52154646
72	CAMK1G	0.52037247
73	DYRK2	0.51385602
74	NTRK3	0.51253504
75	RPS6KA4	0.49790194
76	BTK	0.49775732
77	OBSCN	0.49303186
78	IKBKB	0.48827622
79	PDPK1	0.48367544
80	CSNK1G1	0.48337950
81	GRK1	0.48265024
82	WNK1	0.48119942
83	PRKG1	0.47579244
84	CHEK2	0.47045695
85	CDK7	0.46628018
86	PRKACB	0.45672220
87	PRKACA	0.44804521
88	MAPK8	0.44680024
89	CDC42BPA	0.44652068
90	TIE1	0.43050579
91	CSF1R	0.42849974
92	PTK2B	0.41284332
93	ZAP70	0.40778693
94	KIT	0.40741230
95	JAK2	0.40528182
96	MAP3K13	0.39776473
97	TGFBR1	0.35610524
98	LYN	0.34188272
99	CDK5	0.33568604
100	CDK6	0.32623478

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.90526138
2	Phototransduction_Homo sapiens_hsa04744	3.00910876
3	Morphine addiction_Homo sapiens_hsa05032	2.56887659
4	Taste transduction_Homo sapiens_hsa04742	2.44458633
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.27077595
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.23905191
7	ABC transporters_Homo sapiens_hsa02010	2.21286366
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.14542135
9	Pancreatic secretion_Homo sapiens_hsa04972	2.14276482
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.13350075
11	GABAergic synapse_Homo sapiens_hsa04727	1.97362443
12	Olfactory transduction_Homo sapiens_hsa04740	1.97218932
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.86608234
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82488791
15	Butanoate metabolism_Homo sapiens_hsa00650	1.77055800
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73383035
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71647592
18	Circadian entrainment_Homo sapiens_hsa04713	1.64826681
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.63900888
20	Homologous recombination_Homo sapiens_hsa03440	1.62545077
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.59858536
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57255722
23	Glycerolipid metabolism_Homo sapiens_hsa00561	1.55948862
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53639048
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.46370818
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.40392374
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.40186885
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.27200734
29	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.26967117
30	Lysine degradation_Homo sapiens_hsa00310	1.26857763
31	Serotonergic synapse_Homo sapiens_hsa04726	1.25094049
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24763211
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21899539
34	Protein digestion and absorption_Homo sapiens_hsa04974	1.21633110
35	cAMP signaling pathway_Homo sapiens_hsa04024	1.19468833
36	Sulfur relay system_Homo sapiens_hsa04122	1.17855698
37	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.13340874
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.10382402
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10337176
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.09685255
41	Propanoate metabolism_Homo sapiens_hsa00640	1.05247686
42	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.05198620
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.02817040
44	Cocaine addiction_Homo sapiens_hsa05030	1.00417696
45	Cholinergic synapse_Homo sapiens_hsa04725	0.98779951
46	Retinol metabolism_Homo sapiens_hsa00830	0.98083505
47	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.97498695
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95617467
49	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.94550920
50	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93566383
51	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.91689892
52	Salivary secretion_Homo sapiens_hsa04970	0.88778151
53	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.87242598
54	Renin secretion_Homo sapiens_hsa04924	0.86913277
55	Histidine metabolism_Homo sapiens_hsa00340	0.86545127
56	Dopaminergic synapse_Homo sapiens_hsa04728	0.85357262
57	Gastric acid secretion_Homo sapiens_hsa04971	0.83500470
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82974141
59	Circadian rhythm_Homo sapiens_hsa04710	0.82474300
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81626910
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77794880
62	Amphetamine addiction_Homo sapiens_hsa05031	0.73303122
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70362254
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69756338
65	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64529367
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61737212
67	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.61202286
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.59652840
69	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59353347
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.59057051
71	Type II diabetes mellitus_Homo sapiens_hsa04930	0.57066203
72	Insulin secretion_Homo sapiens_hsa04911	0.56701106
73	Long-term depression_Homo sapiens_hsa04730	0.50144896
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49178839
75	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.49031189
76	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.49011407
77	FoxO signaling pathway_Homo sapiens_hsa04068	0.48932490
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47346522
79	African trypanosomiasis_Homo sapiens_hsa05143	0.47061798
80	Ras signaling pathway_Homo sapiens_hsa04014	0.46212366
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.45652496
82	Melanoma_Homo sapiens_hsa05218	0.44964209
83	Gap junction_Homo sapiens_hsa04540	0.43902789
84	Basal transcription factors_Homo sapiens_hsa03022	0.42360342
85	AMPK signaling pathway_Homo sapiens_hsa04152	0.41637573
86	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41478703
87	Insulin resistance_Homo sapiens_hsa04931	0.41426320
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40341174
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.39343584
90	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39055102
91	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.38952765
92	Rap1 signaling pathway_Homo sapiens_hsa04015	0.38819351
93	Bile secretion_Homo sapiens_hsa04976	0.38312885
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.36857266
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.35988357
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.33161403
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33100289
98	Graft-versus-host disease_Homo sapiens_hsa05332	0.32400348
99	RNA polymerase_Homo sapiens_hsa03020	0.30354144
100	Peroxisome_Homo sapiens_hsa04146	0.28780695

DNM1P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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