ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.79550628
2	sperm motility (GO:0030317)	4.41715729
3	behavioral response to nicotine (GO:0035095)	4.36098316
4	cilium or flagellum-dependent cell motility (GO:0001539)	4.30379945
5	piRNA metabolic process (GO:0034587)	4.20882004
6	establishment of protein localization to Golgi (GO:0072600)	4.16889051
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.16769718
8	L-fucose catabolic process (GO:0042355)	4.12485771
9	fucose catabolic process (GO:0019317)	4.12485771
10	L-fucose metabolic process (GO:0042354)	4.12485771
11	DNA deamination (GO:0045006)	4.09759271
12	protein polyglutamylation (GO:0018095)	4.04778879
13	detection of light stimulus involved in visual perception (GO:0050908)	3.92093341
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.92093341
15	acrosome reaction (GO:0007340)	3.91994607
16	epithelial cilium movement (GO:0003351)	3.91022659
17	cellular ketone body metabolic process (GO:0046950)	3.90168607
18	axoneme assembly (GO:0035082)	3.89298133
19	multicellular organism reproduction (GO:0032504)	3.85101141
20	indole-containing compound catabolic process (GO:0042436)	3.83438780
21	indolalkylamine catabolic process (GO:0046218)	3.83438780
22	tryptophan catabolic process (GO:0006569)	3.83438780
23	protein targeting to Golgi (GO:0000042)	3.77916105
24	indolalkylamine metabolic process (GO:0006586)	3.62668448
25	regulation of cilium movement (GO:0003352)	3.59029660
26	DNA methylation involved in gamete generation (GO:0043046)	3.49816807
27	ketone body metabolic process (GO:1902224)	3.46263249
28	kynurenine metabolic process (GO:0070189)	3.45505499
29	tryptophan metabolic process (GO:0006568)	3.42559323
30	photoreceptor cell maintenance (GO:0045494)	3.40727401
31	cilium movement (GO:0003341)	3.40147529
32	positive regulation of defense response to virus by host (GO:0002230)	3.38656585
33	protein K11-linked deubiquitination (GO:0035871)	3.37703378
34	synapsis (GO:0007129)	3.36780489
35	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.35995451
36	protein localization to Golgi apparatus (GO:0034067)	3.26201808
37	regulation of memory T cell differentiation (GO:0043380)	3.20244880
38	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.17856900
39	negative regulation of mast cell activation (GO:0033004)	3.14998834
40	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14466870
41	spermatid development (GO:0007286)	3.14351239
42	fusion of sperm to egg plasma membrane (GO:0007342)	3.03894143
43	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.03193806
44	rRNA catabolic process (GO:0016075)	2.98362794
45	male meiosis (GO:0007140)	2.98233575
46	retinal cone cell development (GO:0046549)	2.90232522
47	negative regulation of cAMP-mediated signaling (GO:0043951)	2.89395341
48	axonemal dynein complex assembly (GO:0070286)	2.85445359
49	platelet dense granule organization (GO:0060155)	2.84906103
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.83567068
51	negative regulation of telomere maintenance (GO:0032205)	2.80627433
52	tachykinin receptor signaling pathway (GO:0007217)	2.80093230
53	centriole replication (GO:0007099)	2.78621858
54	indole-containing compound metabolic process (GO:0042430)	2.75980105
55	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.75932631
56	sperm-egg recognition (GO:0035036)	2.75787292
57	cellular biogenic amine catabolic process (GO:0042402)	2.74812988
58	amine catabolic process (GO:0009310)	2.74812988
59	auditory receptor cell stereocilium organization (GO:0060088)	2.74710700
60	exogenous drug catabolic process (GO:0042738)	2.73902466
61	cytidine metabolic process (GO:0046087)	2.73866363
62	cytidine catabolic process (GO:0006216)	2.73866363
63	cytidine deamination (GO:0009972)	2.73866363
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.73050472
65	male meiosis I (GO:0007141)	2.70829960
66	protein localization to cilium (GO:0061512)	2.69709431
67	behavioral response to ethanol (GO:0048149)	2.68935536
68	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.68592651
69	NAD biosynthetic process (GO:0009435)	2.66494802
70	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.65934970
71	neuronal action potential (GO:0019228)	2.64830354
72	regulation of meiosis I (GO:0060631)	2.64006894
73	cilium organization (GO:0044782)	2.62855070
74	cAMP catabolic process (GO:0006198)	2.61879909
75	photoreceptor cell development (GO:0042461)	2.60181351
76	rhodopsin mediated signaling pathway (GO:0016056)	2.59683942
77	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.59579822
78	reproduction (GO:0000003)	2.58434666
79	mannosylation (GO:0097502)	2.56053297
80	reflex (GO:0060004)	2.55372480
81	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52708801
82	cilium morphogenesis (GO:0060271)	2.52016328
83	cilium assembly (GO:0042384)	2.50722417
84	calcium ion-dependent exocytosis (GO:0017156)	2.50552132
85	regulation of microtubule-based movement (GO:0060632)	2.48922752
86	protein K63-linked deubiquitination (GO:0070536)	2.48262655
87	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48015148
88	single strand break repair (GO:0000012)	2.47443535
89	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.46593629
90	cellular response to ATP (GO:0071318)	2.46400200
91	drug catabolic process (GO:0042737)	2.45738528
92	regulation of action potential (GO:0098900)	2.45229510
93	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.44715999
94	RNA destabilization (GO:0050779)	2.44261774
95	double-strand break repair via homologous recombination (GO:0000724)	2.41588512
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.40260898
97	seminiferous tubule development (GO:0072520)	2.39252763
98	primary amino compound metabolic process (GO:1901160)	2.39215364
99	sulfation (GO:0051923)	2.39206895
100	coenzyme catabolic process (GO:0009109)	2.38853516

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.79111459
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.68852611
3	VDR_22108803_ChIP-Seq_LS180_Human	3.15545716
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54854980
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.32359346
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29120625
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.20935868
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18053864
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.16917468
10	ER_23166858_ChIP-Seq_MCF-7_Human	2.10288528
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06740081
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.01791505
13	FUS_26573619_Chip-Seq_HEK293_Human	1.97132534
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.95201651
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.95152293
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.93997676
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80814286
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.79077071
19	P300_19829295_ChIP-Seq_ESCs_Human	1.76289476
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.72738615
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.72738615
22	EWS_26573619_Chip-Seq_HEK293_Human	1.68402996
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.67118248
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.66786335
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63906190
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59953381
27	STAT3_23295773_ChIP-Seq_U87_Human	1.57575975
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52487726
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51642551
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49101755
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49101755
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47562651
33	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47562651
34	TCF4_23295773_ChIP-Seq_U87_Human	1.46538722
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46495496
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.45440515
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.43954650
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.42210930
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40645037
40	AR_25329375_ChIP-Seq_VCAP_Human	1.40064557
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39071624
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.36176158
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35402346
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35402346
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.34423629
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34073331
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33218914
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32041679
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31784508
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31323112
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31068023
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30565141
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.29091411
54	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29012287
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28758358
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.28260314
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.23884609
58	GATA3_26560356_Chip-Seq_TH2_Human	1.23794881
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23784098
60	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23697797
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22510542
62	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.22439073
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.22087928
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21342157
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20670364
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.20155461
67	AR_20517297_ChIP-Seq_VCAP_Human	1.19338260
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.18618658
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18358682
70	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.18169672
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.17325991
72	NCOR_22424771_ChIP-Seq_293T_Human	1.17228454
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16289135
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16101623
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15421401
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15368288
77	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.14820073
78	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.11618147
79	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.11203902
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11142084
81	ERA_21632823_ChIP-Seq_H3396_Human	1.11140986
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11031647
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10780471
84	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10404481
85	MYC_18940864_ChIP-ChIP_HL60_Human	1.10229112
86	DROSHA_22980978_ChIP-Seq_HELA_Human	1.10064498
87	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09274639
88	SMRT_27268052_Chip-Seq_Bcells_Human	1.08875835
89	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08732839
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07443996
91	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.06335501
92	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06068019
93	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05750602
94	CDX2_22108803_ChIP-Seq_LS180_Human	1.05363961
95	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04854652
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04651188
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03283304
98	RAC3_21632823_ChIP-Seq_H3396_Human	1.02583019
99	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.02226424
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01773105

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.69694029
2	MP0005410_abnormal_fertilization	3.57876835
3	MP0008877_abnormal_DNA_methylation	2.70351474
4	MP0005645_abnormal_hypothalamus_physiol	2.62726250
5	MP0003195_calcinosis	2.52945869
6	MP0005551_abnormal_eye_electrophysiolog	2.51859342
7	MP0001501_abnormal_sleep_pattern	2.40514111
8	MP0005646_abnormal_pituitary_gland	2.30896522
9	MP0004043_abnormal_pH_regulation	2.19511349
10	MP0001968_abnormal_touch/_nociception	2.01736788
11	MP0000372_irregular_coat_pigmentation	1.97212440
12	MP0001986_abnormal_taste_sensitivity	1.96354099
13	MP0005253_abnormal_eye_physiology	1.95839392
14	MP0003011_delayed_dark_adaptation	1.91178823
15	MP0002102_abnormal_ear_morphology	1.91087840
16	MP0008872_abnormal_physiological_respon	1.89328662
17	MP0003698_abnormal_male_reproductive	1.80684333
18	MP0005167_abnormal_blood-brain_barrier	1.79985396
19	MP0009745_abnormal_behavioral_response	1.79438638
20	MP0003718_maternal_effect	1.77976682
21	MP0002876_abnormal_thyroid_physiology	1.76541319
22	MP0001929_abnormal_gametogenesis	1.67329868
23	MP0006072_abnormal_retinal_apoptosis	1.65875942
24	MP0006276_abnormal_autonomic_nervous	1.64146202
25	MP0005377_hearing/vestibular/ear_phenot	1.59123601
26	MP0003878_abnormal_ear_physiology	1.59123601
27	MP0002234_abnormal_pharynx_morphology	1.58712652
28	MP0008875_abnormal_xenobiotic_pharmacok	1.58586540
29	MP0009046_muscle_twitch	1.57861074
30	MP0000569_abnormal_digit_pigmentation	1.57604301
31	MP0005389_reproductive_system_phenotype	1.56448426
32	MP0001919_abnormal_reproductive_system	1.53815609
33	MP0003787_abnormal_imprinting	1.52589733
34	MP0002138_abnormal_hepatobiliary_system	1.51776676
35	MP0005379_endocrine/exocrine_gland_phen	1.41239059
36	MP0005671_abnormal_response_to	1.38088904
37	MP0001764_abnormal_homeostasis	1.36381952
38	MP0009764_decreased_sensitivity_to	1.34860926
39	MP0002736_abnormal_nociception_after	1.29404754
40	MP0001486_abnormal_startle_reflex	1.27012952
41	MP0008995_early_reproductive_senescence	1.23762160
42	MP0002272_abnormal_nervous_system	1.22764395
43	MP0002210_abnormal_sex_determination	1.21820611
44	MP0005084_abnormal_gallbladder_morpholo	1.20086913
45	MP0000427_abnormal_hair_cycle	1.16820168
46	MP0002638_abnormal_pupillary_reflex	1.14504555
47	MP0002163_abnormal_gland_morphology	1.12664848
48	MP0002160_abnormal_reproductive_system	1.12603337
49	MP0002572_abnormal_emotion/affect_behav	1.12356297
50	MP0004742_abnormal_vestibular_system	1.10241965
51	MP0000631_abnormal_neuroendocrine_gland	1.09980244
52	MP0001835_abnormal_antigen_presentation	1.08526292
53	MP0000653_abnormal_sex_gland	1.07153868
54	MP0001485_abnormal_pinna_reflex	1.06581362
55	MP0000230_abnormal_systemic_arterial	1.06331107
56	MP0001984_abnormal_olfaction	1.06069172
57	MP0010386_abnormal_urinary_bladder	1.05914328
58	MP0004142_abnormal_muscle_tone	1.04049025
59	MP0004484_altered_response_of	1.02161118
60	MP0001970_abnormal_pain_threshold	1.01577919
61	MP0004147_increased_porphyrin_level	0.98978595
62	MP0001145_abnormal_male_reproductive	0.98778601
63	MP0003045_fibrosis	0.98343830
64	MP0002733_abnormal_thermal_nociception	0.98288786
65	MP0005174_abnormal_tail_pigmentation	0.97639968
66	MP0002557_abnormal_social/conspecific_i	0.97428486
67	MP0002229_neurodegeneration	0.94718196
68	MP0003252_abnormal_bile_duct	0.93976864
69	MP0005310_abnormal_salivary_gland	0.93645534
70	MP0002928_abnormal_bile_duct	0.91986549
71	MP0008775_abnormal_heart_ventricle	0.91434489
72	MP0005075_abnormal_melanosome_morpholog	0.90513676
73	MP0002067_abnormal_sensory_capabilities	0.90280515
74	MP0002837_dystrophic_cardiac_calcinosis	0.88582801
75	MP0001905_abnormal_dopamine_level	0.88198990
76	MP0001963_abnormal_hearing_physiology	0.86191179
77	MP0003880_abnormal_central_pattern	0.86032269
78	MP0000383_abnormal_hair_follicle	0.85374289
79	MP0005670_abnormal_white_adipose	0.84127892
80	MP0002064_seizures	0.82947779
81	MP0002735_abnormal_chemical_nociception	0.81529322
82	MP0004885_abnormal_endolymph	0.81212971
83	MP0003136_yellow_coat_color	0.80949416
84	MP0001800_abnormal_humoral_immune	0.80255108
85	MP0002148_abnormal_hypersensitivity_rea	0.79940008
86	MP0002161_abnormal_fertility/fecundity	0.79607958
87	MP0001664_abnormal_digestion	0.79296852
88	MP0005387_immune_system_phenotype	0.79239132
89	MP0001790_abnormal_immune_system	0.79239132
90	MP0003724_increased_susceptibility_to	0.78554482
91	MP0004145_abnormal_muscle_electrophysio	0.77744192
92	MP0005195_abnormal_posterior_eye	0.77390881
93	MP0003786_premature_aging	0.77197774
94	MP0005332_abnormal_amino_acid	0.77021429
95	MP0001873_stomach_inflammation	0.76955325
96	MP0001765_abnormal_ion_homeostasis	0.76258529
97	MP0002693_abnormal_pancreas_physiology	0.74553893
98	MP0005423_abnormal_somatic_nervous	0.73076769
99	MP0001119_abnormal_female_reproductive	0.72835374
100	MP0010329_abnormal_lipoprotein_level	0.72536045

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.45906918
2	Congenital stationary night blindness (HP:0007642)	4.40920121
3	Attenuation of retinal blood vessels (HP:0007843)	4.00484076
4	Pancreatic fibrosis (HP:0100732)	3.88139921
5	Abnormality of the renal cortex (HP:0011035)	3.83113618
6	Gaze-evoked nystagmus (HP:0000640)	3.63012379
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.57160572
8	True hermaphroditism (HP:0010459)	3.51206514
9	Type II lissencephaly (HP:0007260)	3.46817973
10	Nephronophthisis (HP:0000090)	3.45737928
11	Severe visual impairment (HP:0001141)	3.40664355
12	Abnormality of midbrain morphology (HP:0002418)	3.37739412
13	Molar tooth sign on MRI (HP:0002419)	3.37739412
14	Abnormality of the renal medulla (HP:0100957)	3.22908419
15	Chronic hepatic failure (HP:0100626)	3.22169553
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.19569180
17	Polydipsia (HP:0001959)	3.19563934
18	Abnormal drinking behavior (HP:0030082)	3.19563934
19	Genetic anticipation (HP:0003743)	3.17839382
20	Decreased central vision (HP:0007663)	3.07228513
21	Abolished electroretinogram (ERG) (HP:0000550)	3.02699734
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.97048686
23	Hyperventilation (HP:0002883)	2.89959343
24	Tubular atrophy (HP:0000092)	2.84698194
25	Cystic liver disease (HP:0006706)	2.84079579
26	Progressive cerebellar ataxia (HP:0002073)	2.81093339
27	Renal cortical cysts (HP:0000803)	2.80019836
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.74231505
29	Absent/shortened dynein arms (HP:0200106)	2.74231505
30	Medial flaring of the eyebrow (HP:0010747)	2.69419938
31	Pendular nystagmus (HP:0012043)	2.69124203
32	Polyuria (HP:0000103)	2.60344673
33	Cerebellar dysplasia (HP:0007033)	2.49919569
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49493946
35	Abnormality of alanine metabolism (HP:0010916)	2.49493946
36	Hyperalaninemia (HP:0003348)	2.49493946
37	Increased corneal curvature (HP:0100692)	2.47352126
38	Keratoconus (HP:0000563)	2.47352126
39	Autoimmune thrombocytopenia (HP:0001973)	2.44650066
40	Abnormality of macular pigmentation (HP:0008002)	2.41373357
41	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40385559
42	Bile duct proliferation (HP:0001408)	2.36940934
43	Abnormal biliary tract physiology (HP:0012439)	2.36940934
44	Congenital sensorineural hearing impairment (HP:0008527)	2.30274245
45	3-Methylglutaconic aciduria (HP:0003535)	2.28857811
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.27779927
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27779927
48	Tubulointerstitial nephritis (HP:0001970)	2.27394124
49	Lissencephaly (HP:0001339)	2.27277088
50	Retinal dysplasia (HP:0007973)	2.17898739
51	Congenital hepatic fibrosis (HP:0002612)	2.16599541
52	Abnormal urine output (HP:0012590)	2.16391674
53	Prostate neoplasm (HP:0100787)	2.16314288
54	Concave nail (HP:0001598)	2.16076488
55	Ketosis (HP:0001946)	2.14014030
56	Ketoacidosis (HP:0001993)	2.13930392
57	Clumsiness (HP:0002312)	2.13294665
58	Inability to walk (HP:0002540)	2.10423707
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.09636899
60	Abnormal ciliary motility (HP:0012262)	2.09253168
61	Abnormal respiratory motile cilium physiology (HP:0012261)	2.09145847
62	Sclerocornea (HP:0000647)	2.06641704
63	Thyroid-stimulating hormone excess (HP:0002925)	2.02460169
64	Stomach cancer (HP:0012126)	2.01899575
65	Tubulointerstitial abnormality (HP:0001969)	2.00187347
66	Abnormality of the prostate (HP:0008775)	1.97131333
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.96992460
68	Hypoplasia of the fovea (HP:0007750)	1.96992460
69	Hypoproteinemia (HP:0003075)	1.96344712
70	Abnormality of DNA repair (HP:0003254)	1.93041941
71	Pachygyria (HP:0001302)	1.91071650
72	Gait imbalance (HP:0002141)	1.89061947
73	Febrile seizures (HP:0002373)	1.88306840
74	Progressive inability to walk (HP:0002505)	1.87787399
75	Congenital primary aphakia (HP:0007707)	1.87049248
76	Male pseudohermaphroditism (HP:0000037)	1.86652122
77	Macular degeneration (HP:0000608)	1.85790599
78	Postaxial foot polydactyly (HP:0001830)	1.85717389
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.83909890
80	Chorioretinal atrophy (HP:0000533)	1.83307306
81	Absent speech (HP:0001344)	1.80776386
82	Ectopic kidney (HP:0000086)	1.79428468
83	IgG deficiency (HP:0004315)	1.79226791
84	Constricted visual fields (HP:0001133)	1.78992248
85	Abnormality of renal excretion (HP:0011036)	1.78386269
86	Retinitis pigmentosa (HP:0000510)	1.78284071
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77043213
88	Occipital encephalocele (HP:0002085)	1.76084906
89	Decreased circulating renin level (HP:0003351)	1.75807986
90	Methylmalonic aciduria (HP:0012120)	1.75578941
91	Optic nerve hypoplasia (HP:0000609)	1.74911306
92	Large for gestational age (HP:0001520)	1.74304900
93	Nephrogenic diabetes insipidus (HP:0009806)	1.74090079
94	Anencephaly (HP:0002323)	1.73915955
95	Broad-based gait (HP:0002136)	1.73274281
96	Photophobia (HP:0000613)	1.71912914
97	Azoospermia (HP:0000027)	1.71191030
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69520421
99	Stomatitis (HP:0010280)	1.69158778
100	Fair hair (HP:0002286)	1.68054493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.66195764
2	ADRBK2	3.64410451
3	ZAK	3.60768250
4	MAP4K2	3.41109752
5	PINK1	3.30137994
6	TXK	2.85226311
7	TAOK3	2.81451832
8	GRK1	2.74565360
9	BMPR1B	2.58674144
10	INSRR	2.43864688
11	WNK4	2.26582470
12	MAPKAPK3	1.76499815
13	NUAK1	1.74400663
14	TLK1	1.73630487
15	WNK3	1.65144779
16	PLK4	1.60839471
17	ACVR1B	1.58447694
18	STK39	1.54887266
19	OXSR1	1.38384852
20	TNK2	1.32523354
21	CAMKK2	1.31191031
22	MAPK13	1.26472419
23	MAP3K4	1.26194156
24	MAPKAPK5	1.22220884
25	TEC	1.21094791
26	IKBKB	1.17086643
27	DAPK2	1.16039616
28	PTK2B	1.13914963
29	MST4	1.13884839
30	PLK2	1.06462459
31	ADRBK1	1.01662088
32	BCKDK	1.00428853
33	CDK19	1.00355591
34	TRIM28	0.98357156
35	PRKCQ	0.97696283
36	KIT	0.97664848
37	ITK	0.93715821
38	EIF2AK3	0.92564258
39	PIK3CG	0.92488601
40	CSNK1G2	0.91215573
41	SYK	0.89254761
42	CSNK1G3	0.88054253
43	MKNK1	0.86454091
44	TESK2	0.81793336
45	PRKCG	0.79253128
46	CSNK1G1	0.74929968
47	STK38	0.73874971
48	MKNK2	0.71619990
49	STK38L	0.70843543
50	MAP4K1	0.70441207
51	CSNK1A1L	0.70166129
52	CAMK1	0.69541746
53	PRKCE	0.69289980
54	MAP2K7	0.67751074
55	RPS6KA5	0.66205523
56	TIE1	0.63652173
57	TRPM7	0.62744680
58	FLT3	0.62443859
59	BTK	0.61764351
60	JAK3	0.59844442
61	BRD4	0.58497369
62	MARK3	0.56933529
63	CHEK2	0.55888413
64	TGFBR1	0.54508936
65	GRK6	0.54440906
66	RIPK4	0.53554205
67	GRK5	0.53317724
68	BRSK2	0.52485426
69	CAMK2A	0.48730106
70	CASK	0.48548056
71	PAK3	0.48285670
72	STK24	0.47088049
73	CAMK4	0.46969261
74	MAPK11	0.46344269
75	MAP3K7	0.46108999
76	VRK1	0.45986003
77	RPS6KA6	0.45599445
78	PRKAA2	0.45589817
79	PNCK	0.44885440
80	FES	0.43971777
81	LYN	0.40852629
82	MAPK15	0.40224288
83	BCR	0.40201501
84	BMPR2	0.40092157
85	MATK	0.36512231
86	MUSK	0.36305363
87	PRKACA	0.35682784
88	LCK	0.35578930
89	DYRK2	0.34708967
90	GRK7	0.34587773
91	PRKCA	0.33240543
92	PRKAA1	0.32968274
93	CSNK1D	0.31649057
94	CSF1R	0.30687772
95	PHKG1	0.30545697
96	PHKG2	0.30545697
97	IGF1R	0.29269275
98	PIK3CA	0.28713385
99	OBSCN	0.27341015
100	PRKG1	0.27276435

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.17174373
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.62108772
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.44480872
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.35346557
5	Olfactory transduction_Homo sapiens_hsa04740	2.34993410
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.29434068
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29203622
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.25258561
9	Butanoate metabolism_Homo sapiens_hsa00650	2.22273870
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.17697239
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.05154306
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93642537
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.81372839
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.80781237
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.79992224
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.78091236
17	Nicotine addiction_Homo sapiens_hsa05033	1.76902872
18	Taste transduction_Homo sapiens_hsa04742	1.72625269
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.66258616
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.61873824
21	Morphine addiction_Homo sapiens_hsa05032	1.56383745
22	Allograft rejection_Homo sapiens_hsa05330	1.55412966
23	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.52255460
24	Asthma_Homo sapiens_hsa05310	1.50158471
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.49341269
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48076712
27	Homologous recombination_Homo sapiens_hsa03440	1.43710193
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.43482783
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43359233
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41159717
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.38685726
32	ABC transporters_Homo sapiens_hsa02010	1.33580837
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.31941396
34	Caffeine metabolism_Homo sapiens_hsa00232	1.31188898
35	One carbon pool by folate_Homo sapiens_hsa00670	1.29273662
36	Basal transcription factors_Homo sapiens_hsa03022	1.26212987
37	Salivary secretion_Homo sapiens_hsa04970	1.24895091
38	Retinol metabolism_Homo sapiens_hsa00830	1.20385327
39	Circadian entrainment_Homo sapiens_hsa04713	1.16807733
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.16308957
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.15856462
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11104255
43	RNA polymerase_Homo sapiens_hsa03020	1.05543964
44	Regulation of autophagy_Homo sapiens_hsa04140	1.03854613
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02491265
46	Propanoate metabolism_Homo sapiens_hsa00640	1.01622417
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00041431
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99180064
49	RNA degradation_Homo sapiens_hsa03018	0.97855398
50	Peroxisome_Homo sapiens_hsa04146	0.97656031
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.97338392
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97311535
53	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96765140
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.94503434
55	Serotonergic synapse_Homo sapiens_hsa04726	0.90015688
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.89774247
57	GABAergic synapse_Homo sapiens_hsa04727	0.88144427
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.87741140
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.82753597
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.81284114
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80755665
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79370364
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77023796
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73646126
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70524875
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69756304
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.68745698
68	Protein export_Homo sapiens_hsa03060	0.67497486
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.66249493
70	Purine metabolism_Homo sapiens_hsa00230	0.66204037
71	Insulin secretion_Homo sapiens_hsa04911	0.66098070
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.59801675
73	Oxidative phosphorylation_Homo sapiens_hsa00190	0.58628821
74	Long-term depression_Homo sapiens_hsa04730	0.56892502
75	Circadian rhythm_Homo sapiens_hsa04710	0.56206549
76	Renin secretion_Homo sapiens_hsa04924	0.55320494
77	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.55303484
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50476719
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49621652
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49602020
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49358565
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49327978
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47775625
84	Metabolic pathways_Homo sapiens_hsa01100	0.47246162
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46887655
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.46878747
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.44340785
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.43076834
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42589970
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41700004
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.41393258
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41377840
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39321386
94	Gastric acid secretion_Homo sapiens_hsa04971	0.38979129
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38435570
96	Parkinsons disease_Homo sapiens_hsa05012	0.36598412
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.34536866
98	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.34063994
99	Huntingtons disease_Homo sapiens_hsa05016	0.33460585
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.33267448

DNM1P46

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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