DNM1P47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)4.62687059
2histone H3-K36 demethylation (GO:0070544)4.57245921
3positive regulation of gamma-delta T cell activation (GO:0046645)4.52914684
4interkinetic nuclear migration (GO:0022027)4.51495842
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.35687758
6monoubiquitinated protein deubiquitination (GO:0035520)4.24368092
7striated muscle atrophy (GO:0014891)3.98390636
8positive T cell selection (GO:0043368)3.93158618
9B cell receptor signaling pathway (GO:0050853)3.89782028
10skeletal muscle adaptation (GO:0043501)3.83354461
11regulation of gamma-delta T cell differentiation (GO:0045586)3.74442734
12positive thymic T cell selection (GO:0045059)3.60572169
13nucleus localization (GO:0051647)3.57298069
14negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.56442825
15regulation of B cell receptor signaling pathway (GO:0050855)3.52903821
16lipid translocation (GO:0034204)3.47257866
17phospholipid translocation (GO:0045332)3.47257866
18establishment of protein localization to Golgi (GO:0072600)3.47250629
19regulation of gamma-delta T cell activation (GO:0046643)3.43617904
20negative regulation of myotube differentiation (GO:0010832)3.41213607
21positive regulation of granulocyte differentiation (GO:0030854)3.34299123
22muscle atrophy (GO:0014889)3.30516433
23detection of molecule of bacterial origin (GO:0032490)3.24835496
24histone H3-K4 methylation (GO:0051568)3.20389245
25protein K48-linked deubiquitination (GO:0071108)3.16799141
26negative T cell selection (GO:0043383)3.16474873
27histone H3-K4 trimethylation (GO:0080182)3.12550092
28positive regulation of developmental pigmentation (GO:0048087)3.11790863
29mature B cell differentiation involved in immune response (GO:0002313)3.08563890
30protein targeting to Golgi (GO:0000042)3.08280066
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.05784013
32negative regulation of neurotransmitter transport (GO:0051589)3.04275194
33negative thymic T cell selection (GO:0045060)3.02751255
34histone lysine demethylation (GO:0070076)3.01678293
35cerebellar Purkinje cell differentiation (GO:0021702)2.99974605
36nerve growth factor signaling pathway (GO:0038180)2.98774268
37mature B cell differentiation (GO:0002335)2.98634564
38regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.95718470
39histone demethylation (GO:0016577)2.95139292
40regulation of skeletal muscle contraction (GO:0014819)2.95075982
41definitive hemopoiesis (GO:0060216)2.94330573
42histone H3-K9 demethylation (GO:0033169)2.90855063
43histone lysine methylation (GO:0034968)2.86789402
44histone H3-K9 modification (GO:0061647)2.83267227
45positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.82967203
46positive regulation of B cell differentiation (GO:0045579)2.82830893
47regulation of granulocyte differentiation (GO:0030852)2.81829963
48dosage compensation (GO:0007549)2.77785487
49T cell selection (GO:0045058)2.77522614
50positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.77239527
51histone H3-K9 methylation (GO:0051567)2.75208147
52regulation of pigment cell differentiation (GO:0050932)2.73857406
53cellular extravasation (GO:0045123)2.65057510
54replicative senescence (GO:0090399)2.64874592
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62920827
56cytoplasmic mRNA processing body assembly (GO:0033962)2.62873698
57cellular response to epinephrine stimulus (GO:0071872)2.60997984
58negative regulation of granulocyte differentiation (GO:0030853)2.60887640
59microglial cell activation (GO:0001774)2.60820815
60positive regulation of Rab GTPase activity (GO:0032851)2.60310564
61regulation of Rab GTPase activity (GO:0032313)2.60310564
62thymic T cell selection (GO:0045061)2.57458622
63peptidyl-lysine trimethylation (GO:0018023)2.55726950
64platelet-derived growth factor receptor signaling pathway (GO:0048008)2.54031765
65regulation of necroptotic process (GO:0060544)2.52085060
66Golgi to endosome transport (GO:0006895)2.51763316
67histone mRNA catabolic process (GO:0071044)2.50727674
68TOR signaling (GO:0031929)2.48154729
69insulin-like growth factor receptor signaling pathway (GO:0048009)2.47556068
70protein dealkylation (GO:0008214)2.46211492
71protein demethylation (GO:0006482)2.46211492
72positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.43115979
73negative regulation of vascular permeability (GO:0043116)2.42719159
74establishment of nucleus localization (GO:0040023)2.42250387
75macrophage activation involved in immune response (GO:0002281)2.42215915
76hepatocyte apoptotic process (GO:0097284)2.41903060
77negative regulation of inclusion body assembly (GO:0090084)2.41804748
78interleukin-6-mediated signaling pathway (GO:0070102)2.40939721
79striated muscle adaptation (GO:0014888)2.39056276
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35454202
81chromatin silencing (GO:0006342)2.35362630
82positive regulation of Rap GTPase activity (GO:0032854)2.35145838
83protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.35067320
84regulation of muscle hypertrophy (GO:0014743)2.34677805
85negative regulation of skeletal muscle tissue development (GO:0048642)2.33999149
86regulation of B cell differentiation (GO:0045577)2.33419294
87cortical actin cytoskeleton organization (GO:0030866)2.33072211
88protein K63-linked deubiquitination (GO:0070536)2.32735150
89peptidyl-threonine phosphorylation (GO:0018107)2.31736713
90positive regulation of cation channel activity (GO:2001259)2.31111848
91skeletal muscle tissue regeneration (GO:0043403)2.30168188
92negative regulation of erythrocyte differentiation (GO:0045647)2.29541484
93coronary vasculature morphogenesis (GO:0060977)2.28887431
94positive regulation of signal transduction by p53 class mediator (GO:1901798)2.28330100
95activation of JUN kinase activity (GO:0007257)2.27063170
96protein K11-linked deubiquitination (GO:0035871)2.26031674
97negative regulation of neurotransmitter secretion (GO:0046929)2.24582795
98macrophage activation (GO:0042116)2.24519270
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.24082928
100peptidyl-serine phosphorylation (GO:0018105)2.23343149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.31046412
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.28567217
3EZH2_22144423_ChIP-Seq_EOC_Human3.47013209
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34583872
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.20117251
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.83205592
7GATA1_22025678_ChIP-Seq_K562_Human2.70263999
8SCL_19346495_ChIP-Seq_HPC-7_Human2.61352462
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.52623616
10RUNX_20019798_ChIP-Seq_JUKART_Human2.38835679
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19360626
12TP53_16413492_ChIP-PET_HCT116_Human2.04598491
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00229598
14AR_21572438_ChIP-Seq_LNCaP_Human1.97938731
15GBX2_23144817_ChIP-Seq_PC3_Human1.93719827
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80791997
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78925448
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73411690
19DROSHA_22980978_ChIP-Seq_HELA_Human1.71826458
20SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58833835
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57235524
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56029993
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53231926
24AHR_22903824_ChIP-Seq_MCF-7_Human1.49691762
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49564477
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48195769
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47292967
28STAT3_23295773_ChIP-Seq_U87_Human1.44204106
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.42924914
30SPI1_23127762_ChIP-Seq_K562_Human1.40741235
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40659149
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38369940
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36867608
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36162912
35CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33701615
36VDR_24787735_ChIP-Seq_THP-1_Human1.33144801
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.33126959
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32841229
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.31720560
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29774021
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.29455170
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29248410
43SMAD4_21799915_ChIP-Seq_A2780_Human1.26425146
44GATA1_19941826_ChIP-Seq_K562_Human1.26302710
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25801386
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25134638
47GATA2_19941826_ChIP-Seq_K562_Human1.22978097
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21544302
49MYB_26560356_Chip-Seq_TH2_Human1.21108059
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21052557
51TCF4_23295773_ChIP-Seq_U87_Human1.19016084
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18729908
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14822685
54GATA3_27048872_Chip-Seq_THYMUS_Human1.14277991
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11375418
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11070449
57MYB_26560356_Chip-Seq_TH1_Human1.10696732
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06657385
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05122506
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04290625
61TAF15_26573619_Chip-Seq_HEK293_Human1.04129039
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03822673
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03417458
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.01608069
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01491054
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01491054
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.00457033
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00140708
69SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99917007
70POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99428658
71KDM2B_26808549_Chip-Seq_REH_Human0.97644633
72FOXA2_19822575_ChIP-Seq_HepG2_Human0.96051663
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.94836812
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94541835
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93245564
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92317873
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91563506
78BRD4_25478319_ChIP-Seq_HGPS_Human0.90722795
79VDR_24763502_ChIP-Seq_THP-1_Human0.90689694
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90592397
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89968659
82EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89677850
83WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87736861
84SOX2_21211035_ChIP-Seq_LN229_Gbm0.87572207
85AR_19668381_ChIP-Seq_PC3_Human0.86891542
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.86347682
87SMAD3_21741376_ChIP-Seq_EPCs_Human0.85498131
88CJUN_26792858_Chip-Seq_BT549_Human0.85448227
89VDR_21846776_ChIP-Seq_THP-1_Human0.85244720
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85216349
91SMRT_27268052_Chip-Seq_Bcells_Human0.85198863
92BRD4_27068464_Chip-Seq_AML-cells_Mouse0.84844707
93FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.84643778
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83794958
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83737160
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82175869
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81449440
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.81136545
99VDR_22108803_ChIP-Seq_LS180_Human0.81087091
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80956284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.74042529
2MP0008057_abnormal_DNA_replication3.56968275
3MP0003045_fibrosis3.29904222
4MP0003763_abnormal_thymus_physiology2.87828424
5MP0003646_muscle_fatigue2.74313665
6MP0002396_abnormal_hematopoietic_system2.68881189
7MP0000015_abnormal_ear_pigmentation2.48394152
8MP0001661_extended_life_span2.34838782
9MP0004036_abnormal_muscle_relaxation2.21873488
10MP0002009_preneoplasia2.20358704
11MP0004130_abnormal_muscle_cell2.14659191
12MP0000733_abnormal_muscle_development2.02324612
13MP0005174_abnormal_tail_pigmentation1.97580563
14MP0003091_abnormal_cell_migration1.96844061
15MP0003950_abnormal_plasma_membrane1.91928379
16MP0008438_abnormal_cutaneous_collagen1.91631139
17MP0003705_abnormal_hypodermis_morpholog1.82337596
18MP0001835_abnormal_antigen_presentation1.80861247
19MP0003656_abnormal_erythrocyte_physiolo1.80828842
20MP0001879_abnormal_lymphatic_vessel1.79618378
21MP0002168_other_aberrant_phenotype1.77673408
22MP0002166_altered_tumor_susceptibility1.72801692
23MP0001958_emphysema1.71791495
24MP0000371_diluted_coat_color1.66199031
25MP0005275_abnormal_skin_tensile1.62641110
26MP0010368_abnormal_lymphatic_system1.62200110
27MP0003300_gastrointestinal_ulcer1.62055099
28MP0004381_abnormal_hair_follicle1.55012223
29MP0005171_absent_coat_pigmentation1.51573102
30MP0004084_abnormal_cardiac_muscle1.48554246
31MP0008260_abnormal_autophagy1.43544925
32MP0002332_abnormal_exercise_endurance1.41918774
33MP0001800_abnormal_humoral_immune1.39051636
34MP0003303_peritoneal_inflammation1.37140643
35MP0003690_abnormal_glial_cell1.35972494
36MP0010307_abnormal_tumor_latency1.34511347
37MP0004808_abnormal_hematopoietic_stem1.33034889
38MP0003279_aneurysm1.23464397
39MP0000685_abnormal_immune_system1.22922383
40MP0002108_abnormal_muscle_morphology1.21277409
41MP0000372_irregular_coat_pigmentation1.18738364
42MP0005076_abnormal_cell_differentiation1.17731582
43MP0000465_gastrointestinal_hemorrhage1.17301970
44MP0005503_abnormal_tendon_morphology1.17212932
45MP0003632_abnormal_nervous_system1.16940262
46MP0004145_abnormal_muscle_electrophysio1.16536734
47MP0002398_abnormal_bone_marrow1.16343467
48MP0000703_abnormal_thymus_morphology1.16222276
49MP0002095_abnormal_skin_pigmentation1.15827083
50MP0005670_abnormal_white_adipose1.15465322
51MP0005167_abnormal_blood-brain_barrier1.13124202
52MP0003828_pulmonary_edema1.11928590
53MP0005397_hematopoietic_system_phenotyp1.06444995
54MP0001545_abnormal_hematopoietic_system1.06444995
55MP0009278_abnormal_bone_marrow1.06097851
56MP0005310_abnormal_salivary_gland1.06079517
57MP0000747_muscle_weakness1.05142194
58MP0003724_increased_susceptibility_to1.03890540
59MP0000759_abnormal_skeletal_muscle1.03262238
60MP0001915_intracranial_hemorrhage1.02120962
61MP0005409_darkened_coat_color1.01986991
62MP0000013_abnormal_adipose_tissue1.01171157
63MP0004883_abnormal_blood_vessel0.98542819
64MP0003866_abnormal_defecation0.95846624
65MP0002998_abnormal_bone_remodeling0.94737535
66MP0004134_abnormal_chest_morphology0.94158086
67MP0004233_abnormal_muscle_weight0.94093502
68MP0000749_muscle_degeneration0.93087922
69MP0002722_abnormal_immune_system0.92929961
70MP0000716_abnormal_immune_system0.91696391
71MP0002420_abnormal_adaptive_immunity0.91544772
72MP0002723_abnormal_immune_serum0.90697817
73MP0002269_muscular_atrophy0.90308481
74MP0000767_abnormal_smooth_muscle0.90033628
75MP0005464_abnormal_platelet_physiology0.89503785
76MP0002452_abnormal_antigen_presenting0.89330215
77MP0001819_abnormal_immune_cell0.87733739
78MP0000689_abnormal_spleen_morphology0.86709916
79MP0003631_nervous_system_phenotype0.86404756
80MP0004484_altered_response_of0.86052798
81MP0002419_abnormal_innate_immunity0.83923570
82MP0002933_joint_inflammation0.83846231
83MP0003172_abnormal_lysosome_physiology0.82896187
84MP0002127_abnormal_cardiovascular_syste0.82493037
85MP0002075_abnormal_coat/hair_pigmentati0.82379528
86MP0006054_spinal_hemorrhage0.81882035
87MP0000003_abnormal_adipose_tissue0.79546469
88MP0003868_abnormal_feces_composition0.78316062
89MP0010352_gastrointestinal_tract_polyps0.77995924
90MP0002006_tumorigenesis0.77437677
91MP0002971_abnormal_brown_adipose0.75241480
92MP0005387_immune_system_phenotype0.73936147
93MP0001790_abnormal_immune_system0.73936147
94MP0004947_skin_inflammation0.72863420
95MP0001664_abnormal_digestion0.71370580
96MP0009115_abnormal_fat_cell0.69481149
97MP0003633_abnormal_nervous_system0.68732738
98MP0004087_abnormal_muscle_fiber0.67594062
99MP0002429_abnormal_blood_cell0.67353426
100MP0005621_abnormal_cell_physiology0.66006066

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.59204592
2Colitis (HP:0002583)3.71638100
3Aortic aneurysm (HP:0004942)3.55243101
4Narrow palate (HP:0000189)3.49880137
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.35319706
6Autoimmune thrombocytopenia (HP:0001973)3.22291819
7Neoplasm of the heart (HP:0100544)3.11961438
8T lymphocytopenia (HP:0005403)3.11474974
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09420249
10Short 4th metacarpal (HP:0010044)3.09420249
11Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.96751855
12Hyperkalemia (HP:0002153)2.90334403
13Abnormality of T cell number (HP:0011839)2.85238306
14Broad ribs (HP:0000885)2.83976935
15Thyroiditis (HP:0100646)2.82871547
16Mask-like facies (HP:0000298)2.82120674
17Dysmetric saccades (HP:0000641)2.74559058
18Lip pit (HP:0100267)2.59836948
19Genetic anticipation (HP:0003743)2.59302998
20Spontaneous hematomas (HP:0007420)2.58148310
21IgA deficiency (HP:0002720)2.49823432
22Truncal obesity (HP:0001956)2.41494298
23Sparse lateral eyebrow (HP:0005338)2.39593063
24Abnormality of the columella (HP:0009929)2.36161650
25Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.32330736
26Hypoplasia of the thymus (HP:0000778)2.31368790
27Subacute progressive viral hepatitis (HP:0006572)2.30362434
28Neonatal hypoglycemia (HP:0001998)2.28289862
29Inflammation of the large intestine (HP:0002037)2.27814210
30Acute myeloid leukemia (HP:0004808)2.25952080
31Aortic dissection (HP:0002647)2.24289715
32Overgrowth (HP:0001548)2.20565953
33Anal stenosis (HP:0002025)2.18911594
34Persistence of primary teeth (HP:0006335)2.17804430
35Hypoplasia of the iris (HP:0007676)2.16817742
36Recurrent cutaneous fungal infections (HP:0011370)2.16201286
37Chronic mucocutaneous candidiasis (HP:0002728)2.16201286
38Prominent nose (HP:0000448)2.15182609
39Abnormality of the epiphyses of the hand (HP:0005924)2.14010019
40Gingivitis (HP:0000230)2.13565811
41Dislocated radial head (HP:0003083)2.12979173
42Difficulty running (HP:0009046)2.12941841
43Recurrent fungal infections (HP:0002841)2.12890223
44Sandal gap (HP:0001852)2.11712836
45Conjunctival telangiectasia (HP:0000524)2.11329045
46Recurrent viral infections (HP:0004429)2.10927318
47Ureteral obstruction (HP:0006000)2.10219260
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.09946512
49Viral hepatitis (HP:0006562)2.08603530
50Scanning speech (HP:0002168)2.07216107
51Recurrent bacterial skin infections (HP:0005406)2.07013933
52Spondylolisthesis (HP:0003302)2.05971512
53IgM deficiency (HP:0002850)2.02660504
54Gastrointestinal inflammation (HP:0004386)2.00493740
55Heterotopia (HP:0002282)2.00125490
56Ectopic kidney (HP:0000086)1.99593931
57Thoracolumbar scoliosis (HP:0002944)1.97414612
58Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.96907784
59Abnormality of the 4th metacarpal (HP:0010012)1.96705792
60Slow saccadic eye movements (HP:0000514)1.96288382
61Gaze-evoked nystagmus (HP:0000640)1.96189594
62Abnormality of the radial head (HP:0003995)1.93691834
63Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92860736
64Mitral valve prolapse (HP:0001634)1.91931464
65Interstitial pulmonary disease (HP:0006530)1.91493452
66Long eyelashes (HP:0000527)1.90275366
67Cerebral aneurysm (HP:0004944)1.88423796
68Postural instability (HP:0002172)1.87931527
69Panhypogammaglobulinemia (HP:0003139)1.85685836
70Blue irides (HP:0000635)1.85526333
71Syringomyelia (HP:0003396)1.84925148
72Spinal cord lesions (HP:0100561)1.84925148
73Glucose intolerance (HP:0000833)1.83704811
74Fair hair (HP:0002286)1.83357543
75Impaired smooth pursuit (HP:0007772)1.79838626
76Abnormality of the sella turcica (HP:0002679)1.79812642
77Cellulitis (HP:0100658)1.78604428
78Ureteral stenosis (HP:0000071)1.78332008
79Gastrointestinal infarctions (HP:0005244)1.77296177
80Absent frontal sinuses (HP:0002688)1.77247752
81Abnormal glucose tolerance (HP:0001952)1.76986077
82Submucous cleft hard palate (HP:0000176)1.76381433
83Short 5th finger (HP:0009237)1.75676239
84Intestinal fistula (HP:0100819)1.75485082
85Deformed sella turcica (HP:0002681)1.74440592
86Protruding tongue (HP:0010808)1.72177938
87Vertebral arch anomaly (HP:0008438)1.72117663
88Aortic regurgitation (HP:0001659)1.71751940
89Rectal prolapse (HP:0002035)1.68262789
90Delayed closure of the anterior fontanelle (HP:0001476)1.67834621
91Hypoplastic iliac wings (HP:0002866)1.67826839
92Onion bulb formation (HP:0003383)1.65598638
93Pulmonary artery stenosis (HP:0004415)1.65001764
94Abnormality of the periventricular white matter (HP:0002518)1.63832317
95Osteolytic defects of the hand bones (HP:0009699)1.63038413
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.63038413
97Recurrent abscess formation (HP:0002722)1.62975679
98Palpebral edema (HP:0100540)1.62648583
99Generalized hypopigmentation of hair (HP:0011358)1.62132924
100Resting tremor (HP:0002322)1.61581345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.04994957
2FRK2.89572656
3EEF2K2.69711322
4TRIB32.58992503
5CDK122.54636440
6PIK3CG2.29948518
7TRPM71.99403754
8ZAK1.95017628
9WNK11.94943075
10JAK31.94903621
11CAMK1D1.89496133
12MAP3K21.86335482
13MAP2K31.76084273
14TLK11.71505073
15CAMK1G1.70117511
16PRPF4B1.68969574
17SGK21.68103021
18CAMKK21.52784220
19NEK91.52224364
20CAMK41.46763667
21AKT31.36286102
22BTK1.35700688
23JAK11.34168212
24FGFR31.31989725
25FES1.31099251
26MELK1.30053187
27SGK31.28112756
28SYK1.28069668
29TTN1.25522265
30STK241.25252846
31NLK1.19622826
32STK41.18734942
33HCK1.18341914
34TEC1.16283309
35BRD41.15973157
36MAP3K71.15543369
37MARK21.15058064
38KIT1.12775185
39MAP3K101.11390560
40MAP3K31.11303806
41EPHA31.11002408
42MAP4K11.09709743
43SGK4941.06862763
44SGK2231.06862763
45RPS6KA51.05355927
46MAPK111.00835470
47MAP3K60.95056491
48RET0.94400224
49RIPK40.91095882
50PIM10.89458142
51RPS6KC10.87966806
52RPS6KL10.87966806
53RPS6KA60.87947156
54PDK10.83919491
55TYK20.83117211
56ICK0.81351017
57STK390.79816276
58MAPK120.79043237
59CDK60.77899693
60PDGFRB0.76867210
61IKBKE0.76111019
62MTOR0.76069132
63IRAK10.75744099
64PRKAA20.73946901
65CAMK10.72873737
66ZAP700.72434098
67CCNB10.72216553
68CDC42BPA0.70144661
69JAK20.70087640
70SGK10.69608005
71CAMKK10.69547267
72GRK60.68473038
73STK380.68067540
74LCK0.67642373
75ITK0.66536022
76PKN20.65860709
77MYLK0.64952975
78CSF1R0.64655595
79MAP3K130.64288608
80LYN0.63288542
81MARK30.62221415
82PDPK10.60926713
83OBSCN0.58223442
84MAPK70.57161202
85ACVR1B0.56880483
86EGFR0.55839261
87PTK2B0.55285443
88TGFBR20.55044768
89CDK40.53295139
90PRKAA10.53294455
91PRKCQ0.52688781
92ERBB20.52090191
93RPS6KA20.51806251
94TAOK30.50849898
95PDGFRA0.50021610
96TIE10.48124513
97MAP3K140.47495214
98FGR0.47336286
99DDR20.46900976
100CSK0.44621155

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.49285868
2Alcoholism_Homo sapiens_hsa050342.30054887
3B cell receptor signaling pathway_Homo sapiens_hsa046621.92304675
4Non-small cell lung cancer_Homo sapiens_hsa052231.80984031
5Phosphatidylinositol signaling system_Homo sapiens_hsa040701.76825579
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.61007290
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53898193
8Platelet activation_Homo sapiens_hsa046111.51479201
9Dorso-ventral axis formation_Homo sapiens_hsa043201.50595118
10Glioma_Homo sapiens_hsa052141.47904639
11Inositol phosphate metabolism_Homo sapiens_hsa005621.43525869
12mTOR signaling pathway_Homo sapiens_hsa041501.43441510
13Chronic myeloid leukemia_Homo sapiens_hsa052201.41139730
14Viral carcinogenesis_Homo sapiens_hsa052031.39758734
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39361433
16Osteoclast differentiation_Homo sapiens_hsa043801.35945417
17Lysine degradation_Homo sapiens_hsa003101.29493959
18Pancreatic cancer_Homo sapiens_hsa052121.29408259
19Acute myeloid leukemia_Homo sapiens_hsa052211.28879532
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28553497
21Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.26505121
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25147986
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.22943899
24Vascular smooth muscle contraction_Homo sapiens_hsa042701.17045272
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.17010599
26T cell receptor signaling pathway_Homo sapiens_hsa046601.16201558
27FoxO signaling pathway_Homo sapiens_hsa040681.11764758
28Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11439708
29Renal cell carcinoma_Homo sapiens_hsa052111.10122897
30Leishmaniasis_Homo sapiens_hsa051401.09884830
31Focal adhesion_Homo sapiens_hsa045101.08564241
32Toxoplasmosis_Homo sapiens_hsa051451.07580613
33Prolactin signaling pathway_Homo sapiens_hsa049171.07367594
34ABC transporters_Homo sapiens_hsa020101.07251377
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06214963
36MicroRNAs in cancer_Homo sapiens_hsa052061.05876238
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.04481371
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03640654
39Cholinergic synapse_Homo sapiens_hsa047250.99735001
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.99465086
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99427416
42Endometrial cancer_Homo sapiens_hsa052130.98954020
43ErbB signaling pathway_Homo sapiens_hsa040120.98678806
44Renin secretion_Homo sapiens_hsa049240.98377282
45GnRH signaling pathway_Homo sapiens_hsa049120.98376638
46Long-term potentiation_Homo sapiens_hsa047200.96991426
47Type II diabetes mellitus_Homo sapiens_hsa049300.96922267
48VEGF signaling pathway_Homo sapiens_hsa043700.96478055
49Small cell lung cancer_Homo sapiens_hsa052220.96214300
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94976129
51Measles_Homo sapiens_hsa051620.94687384
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.94449560
53Calcium signaling pathway_Homo sapiens_hsa040200.92632305
54Choline metabolism in cancer_Homo sapiens_hsa052310.91281125
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90140924
56Oxytocin signaling pathway_Homo sapiens_hsa049210.89942680
57Prostate cancer_Homo sapiens_hsa052150.85750280
58Hepatitis B_Homo sapiens_hsa051610.85433933
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81523181
60Influenza A_Homo sapiens_hsa051640.81076438
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80869476
62Tuberculosis_Homo sapiens_hsa051520.80092959
63Colorectal cancer_Homo sapiens_hsa052100.79868047
64TNF signaling pathway_Homo sapiens_hsa046680.79234500
65Staphylococcus aureus infection_Homo sapiens_hsa051500.79007883
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77801261
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76955072
68Primary immunodeficiency_Homo sapiens_hsa053400.76639802
69Estrogen signaling pathway_Homo sapiens_hsa049150.75455212
70Melanoma_Homo sapiens_hsa052180.75375098
71Pancreatic secretion_Homo sapiens_hsa049720.75023913
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74896691
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73962993
74Circadian entrainment_Homo sapiens_hsa047130.73453813
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72573125
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.70869920
77MAPK signaling pathway_Homo sapiens_hsa040100.69746005
78HIF-1 signaling pathway_Homo sapiens_hsa040660.69515591
79ECM-receptor interaction_Homo sapiens_hsa045120.68478709
80AMPK signaling pathway_Homo sapiens_hsa041520.67947715
81Malaria_Homo sapiens_hsa051440.66686302
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65141544
83Insulin resistance_Homo sapiens_hsa049310.64286527
84Proteoglycans in cancer_Homo sapiens_hsa052050.62902151
85Apoptosis_Homo sapiens_hsa042100.62331239
86Salivary secretion_Homo sapiens_hsa049700.61227220
87Gastric acid secretion_Homo sapiens_hsa049710.61203074
88Dilated cardiomyopathy_Homo sapiens_hsa054140.60050683
89Long-term depression_Homo sapiens_hsa047300.59293817
90Chemokine signaling pathway_Homo sapiens_hsa040620.58971478
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57858596
92Taste transduction_Homo sapiens_hsa047420.57274524
93Graft-versus-host disease_Homo sapiens_hsa053320.56625528
94Rap1 signaling pathway_Homo sapiens_hsa040150.56344460
95Ras signaling pathway_Homo sapiens_hsa040140.55408054
96Pathways in cancer_Homo sapiens_hsa052000.54172393
97Morphine addiction_Homo sapiens_hsa050320.53758992
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52656448
99HTLV-I infection_Homo sapiens_hsa051660.52572909
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.52066579

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