DNM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48335278
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.38205442
3neuronal action potential propagation (GO:0019227)5.37305900
4neuron cell-cell adhesion (GO:0007158)5.35483444
5vocalization behavior (GO:0071625)5.23122337
6synaptic vesicle maturation (GO:0016188)5.16453434
7synaptic vesicle exocytosis (GO:0016079)5.05966629
8sodium ion export (GO:0071436)5.03625385
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.82432531
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76887321
11locomotory exploration behavior (GO:0035641)4.69685023
12regulation of synaptic vesicle exocytosis (GO:2000300)4.69091089
13protein localization to synapse (GO:0035418)4.66327621
14glutamate secretion (GO:0014047)4.51379859
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.48956135
16presynaptic membrane assembly (GO:0097105)4.44315320
17regulation of glutamate receptor signaling pathway (GO:1900449)4.32806797
18presynaptic membrane organization (GO:0097090)4.27475984
19neurotransmitter secretion (GO:0007269)4.22164718
20gamma-aminobutyric acid transport (GO:0015812)4.21537959
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.19270599
22regulation of synaptic vesicle transport (GO:1902803)4.11274518
23postsynaptic membrane organization (GO:0001941)4.09757990
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03040635
25glutamate receptor signaling pathway (GO:0007215)3.97564617
26synaptic transmission, glutamatergic (GO:0035249)3.96864025
27neuron-neuron synaptic transmission (GO:0007270)3.95545089
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86907707
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.82616784
30exploration behavior (GO:0035640)3.81456129
31positive regulation of membrane potential (GO:0045838)3.80389144
32neurotransmitter-gated ion channel clustering (GO:0072578)3.76839954
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.69469696
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.68993592
35regulation of neuronal synaptic plasticity (GO:0048168)3.67519257
36transmission of nerve impulse (GO:0019226)3.67355597
37neurotransmitter transport (GO:0006836)3.66471093
38neuromuscular process controlling posture (GO:0050884)3.66075022
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63594388
40potassium ion homeostasis (GO:0055075)3.60962895
41cell communication by electrical coupling (GO:0010644)3.58217192
42regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.57719106
43cerebellar Purkinje cell differentiation (GO:0021702)3.57365005
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57122307
45gamma-aminobutyric acid signaling pathway (GO:0007214)3.56570612
46positive regulation of synaptic transmission, GABAergic (GO:0032230)3.56299562
47cellular sodium ion homeostasis (GO:0006883)3.52824806
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51631871
49amino acid import (GO:0043090)3.50286607
50regulation of postsynaptic membrane potential (GO:0060078)3.49490442
51neuron recognition (GO:0008038)3.49216531
52long-term memory (GO:0007616)3.48350192
53cellular potassium ion homeostasis (GO:0030007)3.38700436
54startle response (GO:0001964)3.37291604
55adult walking behavior (GO:0007628)3.36042460
56neurotransmitter uptake (GO:0001504)3.35775930
57dendritic spine morphogenesis (GO:0060997)3.35705661
58potassium ion import (GO:0010107)3.35562005
59positive regulation of synapse assembly (GO:0051965)3.32392551
60regulation of neurotransmitter levels (GO:0001505)3.31781722
61regulation of synapse structural plasticity (GO:0051823)3.30964038
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30446528
63layer formation in cerebral cortex (GO:0021819)3.30341291
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.29537374
65membrane hyperpolarization (GO:0060081)3.28344654
66cell differentiation in hindbrain (GO:0021533)3.26738450
67regulation of neurotransmitter secretion (GO:0046928)3.22377857
68regulation of synapse maturation (GO:0090128)3.21008726
69long-chain fatty acid biosynthetic process (GO:0042759)3.20427430
70glycine transport (GO:0015816)3.20209760
71regulation of synaptic transmission, GABAergic (GO:0032228)3.17058232
72membrane depolarization (GO:0051899)3.15542110
73negative regulation of dendrite morphogenesis (GO:0050774)3.15159693
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14846798
75membrane depolarization during action potential (GO:0086010)3.13150337
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11637508
77regulation of respiratory system process (GO:0044065)3.11303153
78* synapse assembly (GO:0007416)3.10957319
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09159306
80neuronal ion channel clustering (GO:0045161)3.08220698
81positive regulation of neurotransmitter secretion (GO:0001956)3.08137618
82proline transport (GO:0015824)3.08100644
83auditory behavior (GO:0031223)3.07567771
84synaptic vesicle endocytosis (GO:0048488)3.07169928
85mating behavior (GO:0007617)3.06967942
86central nervous system myelination (GO:0022010)3.06510548
87axon ensheathment in central nervous system (GO:0032291)3.06510548
88cerebellar granule cell differentiation (GO:0021707)3.05387768
89regulation of neurotransmitter transport (GO:0051588)3.04969691
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02593872
91long-term synaptic potentiation (GO:0060291)3.02179230
92response to auditory stimulus (GO:0010996)3.01700772
93regulation of vesicle fusion (GO:0031338)3.01262608
94serotonin metabolic process (GO:0042428)3.00736828
95dendrite morphogenesis (GO:0048813)3.00307439
96axonal fasciculation (GO:0007413)3.00091971
97positive regulation of neurotransmitter transport (GO:0051590)2.99176986
98learning (GO:0007612)2.98279894
99positive regulation of dendritic spine morphogenesis (GO:0061003)2.96975701
100detection of calcium ion (GO:0005513)2.96323786
101positive regulation of dendritic spine development (GO:0060999)2.96155451
102acidic amino acid transport (GO:0015800)2.95746858
103regulation of synaptic plasticity (GO:0048167)2.94874694
104response to histamine (GO:0034776)2.94312530
105regulation of synaptic transmission (GO:0050804)2.94259990
106regulation of dendritic spine development (GO:0060998)2.93941171
107L-amino acid import (GO:0043092)2.93725234
108prepulse inhibition (GO:0060134)2.92743222
109regulation of voltage-gated calcium channel activity (GO:1901385)2.92262512
110neuromuscular process controlling balance (GO:0050885)2.91929696
111regulation of dendritic spine morphogenesis (GO:0061001)2.91112687
112cell communication involved in cardiac conduction (GO:0086065)2.89262111
113synaptic transmission (GO:0007268)2.87563437
114mechanosensory behavior (GO:0007638)2.86763482
115C4-dicarboxylate transport (GO:0015740)2.85600303
116cell migration in hindbrain (GO:0021535)2.85513442
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.85397466
118behavioral response to cocaine (GO:0048148)2.84924577
119regulation of respiratory gaseous exchange (GO:0043576)2.84133967
120short-term memory (GO:0007614)2.84009480
121positive regulation of synapse maturation (GO:0090129)2.83414244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.17291452
2* GBX2_23144817_ChIP-Seq_PC3_Human3.81208760
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13867150
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12459468
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04753414
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68680713
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68680713
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62713616
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.56790888
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55651543
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55194548
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50962251
13REST_21632747_ChIP-Seq_MESCs_Mouse2.44083448
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43713965
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40720618
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.39697507
17TAF15_26573619_Chip-Seq_HEK293_Human2.23589291
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20245707
19DROSHA_22980978_ChIP-Seq_HELA_Human2.19478817
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18892791
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.11565767
22AR_21572438_ChIP-Seq_LNCaP_Human2.07100672
23* REST_18959480_ChIP-ChIP_MESCs_Mouse1.96568158
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.93876007
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91749535
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88836471
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87574969
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86010518
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79703717
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79566253
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77749545
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.70426100
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67860973
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65045692
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60665443
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.59468349
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59070047
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58078149
39P300_19829295_ChIP-Seq_ESCs_Human1.57697130
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57338894
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49935392
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48394091
43IGF1R_20145208_ChIP-Seq_DFB_Human1.46021941
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45446522
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44907912
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.41807427
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40088079
48* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38090715
49ZNF274_21170338_ChIP-Seq_K562_Hela1.36527952
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36138842
51* RNF2_27304074_Chip-Seq_NSC_Mouse1.35019280
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.34836147
53* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34816102
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34718055
55* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32784271
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32330667
57STAT3_23295773_ChIP-Seq_U87_Human1.29757643
58AR_25329375_ChIP-Seq_VCAP_Human1.24707267
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.21063362
60ER_23166858_ChIP-Seq_MCF-7_Human1.19670362
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.18879604
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18124334
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14974911
64TCF4_23295773_ChIP-Seq_U87_Human1.14874407
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14836039
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14758672
67* SMAD_19615063_ChIP-ChIP_OVARY_Human1.12106429
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10118181
69* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09963772
70* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09414741
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09098735
72RUNX2_22187159_ChIP-Seq_PCA_Human1.08626545
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08310816
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05585491
75* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05139855
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04882734
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04538993
78* AR_19668381_ChIP-Seq_PC3_Human1.04387068
79* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04293931
80VDR_22108803_ChIP-Seq_LS180_Human1.03987710
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03695887
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02864455
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02656342
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01822056
85FUS_26573619_Chip-Seq_HEK293_Human1.01601912
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.00892943
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.00857156
88* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99646672
89* AHR_22903824_ChIP-Seq_MCF-7_Human0.99356963
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97966289
91YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96483459
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96039796
93NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94989099
94* E2F1_18555785_Chip-Seq_ESCs_Mouse0.94902603
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94854922
96* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94781464
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93901137
98TP53_16413492_ChIP-PET_HCT116_Human0.93609314
99* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93216538
100BCAT_22108803_ChIP-Seq_LS180_Human0.93093254
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93005916
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.92447860
103* CMYC_18555785_Chip-Seq_ESCs_Mouse0.91216909
104* P53_22387025_ChIP-Seq_ESCs_Mouse0.90778107
105* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90572831
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90298701
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90298701
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90024705
109KDM2B_26808549_Chip-Seq_REH_Human0.89996771
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89580488
111JUN_21703547_ChIP-Seq_K562_Human0.89570475
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.88962838
113HTT_18923047_ChIP-ChIP_STHdh_Human0.88803728
114SOX9_26525672_Chip-Seq_HEART_Mouse0.87814470
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.87741581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.00508516
2MP0004859_abnormal_synaptic_plasticity4.89286750
3MP0003635_abnormal_synaptic_transmissio3.69379872
4MP0009046_muscle_twitch3.53449354
5MP0004270_analgesia3.45604858
6MP0009745_abnormal_behavioral_response3.21600761
7MP0001968_abnormal_touch/_nociception3.20173812
8MP0002064_seizures3.11967603
9MP0005423_abnormal_somatic_nervous2.98538563
10MP0002734_abnormal_mechanical_nocicepti2.84636920
11MP0002272_abnormal_nervous_system2.81942809
12MP0002063_abnormal_learning/memory/cond2.79332604
13MP0001486_abnormal_startle_reflex2.69795538
14MP0002572_abnormal_emotion/affect_behav2.61939009
15MP0002735_abnormal_chemical_nociception2.57817870
16MP0002736_abnormal_nociception_after2.45581691
17MP0006276_abnormal_autonomic_nervous2.31025680
18MP0002822_catalepsy2.26626968
19MP0002067_abnormal_sensory_capabilities2.25246500
20MP0001501_abnormal_sleep_pattern2.22588809
21MP0002733_abnormal_thermal_nociception2.16276904
22MP0001970_abnormal_pain_threshold2.14024427
23MP0001440_abnormal_grooming_behavior2.00908217
24MP0008569_lethality_at_weaning2.00421189
25MP0001188_hyperpigmentation1.98381759
26MP0004142_abnormal_muscle_tone1.95424352
27MP0002184_abnormal_innervation1.92513516
28MP0000778_abnormal_nervous_system1.87097335
29MP0002557_abnormal_social/conspecific_i1.82888269
30MP0004924_abnormal_behavior1.73960775
31MP0005386_behavior/neurological_phenoty1.73960775
32MP0005646_abnormal_pituitary_gland1.66301038
33MP0001529_abnormal_vocalization1.62672990
34MP0005551_abnormal_eye_electrophysiolog1.57721706
35MP0001984_abnormal_olfaction1.57205907
36MP0000955_abnormal_spinal_cord1.55607152
37MP0001905_abnormal_dopamine_level1.55375448
38MP0005645_abnormal_hypothalamus_physiol1.55192709
39MP0002882_abnormal_neuron_morphology1.51652477
40MP0004811_abnormal_neuron_physiology1.51465697
41MP0002066_abnormal_motor_capabilities/c1.44287439
42MP0005409_darkened_coat_color1.44051592
43MP0004885_abnormal_endolymph1.43176652
44MP0003329_amyloid_beta_deposits1.41673803
45MP0004742_abnormal_vestibular_system1.41252644
46MP0000920_abnormal_myelination1.38081583
47MP0001502_abnormal_circadian_rhythm1.34472517
48MP0002229_neurodegeneration1.34247866
49MP0003122_maternal_imprinting1.34163788
50MP0003879_abnormal_hair_cell1.28139186
51MP0002909_abnormal_adrenal_gland1.27377384
52MP0004858_abnormal_nervous_system1.26054964
53MP0003633_abnormal_nervous_system1.22417881
54MP0003787_abnormal_imprinting1.18955891
55MP0004145_abnormal_muscle_electrophysio1.17622704
56MP0009780_abnormal_chondrocyte_physiolo1.07962451
57MP0002752_abnormal_somatic_nervous1.07626424
58MP0001986_abnormal_taste_sensitivity1.07265506
59MP0003631_nervous_system_phenotype1.06914477
60MP0005171_absent_coat_pigmentation1.06706032
61MP0002638_abnormal_pupillary_reflex1.06448823
62MP0008877_abnormal_DNA_methylation1.06413828
63MP0003634_abnormal_glial_cell1.03088863
64MP0002152_abnormal_brain_morphology1.02600926
65MP0001963_abnormal_hearing_physiology1.00422210
66MP0000751_myopathy0.93438688
67MP0000631_abnormal_neuroendocrine_gland0.93234271
68MP0006072_abnormal_retinal_apoptosis0.91251701
69MP0005167_abnormal_blood-brain_barrier0.90796953
70MP0009379_abnormal_foot_pigmentation0.90642587
71MP0003690_abnormal_glial_cell0.88362837
72MP0003632_abnormal_nervous_system0.87887626
73MP0003136_yellow_coat_color0.85967332
74MP0003123_paternal_imprinting0.84071612
75MP0002876_abnormal_thyroid_physiology0.83791985
76MP0005253_abnormal_eye_physiology0.83319969
77MP0005394_taste/olfaction_phenotype0.82531605
78MP0005499_abnormal_olfactory_system0.82531605
79MP0010386_abnormal_urinary_bladder0.82450893
80MP0004130_abnormal_muscle_cell0.82061702
81MP0001177_atelectasis0.81882252
82MP0005464_abnormal_platelet_physiology0.81236399
83MP0002069_abnormal_eating/drinking_beha0.81044931
84MP0001299_abnormal_eye_distance/0.80806544
85MP0003121_genomic_imprinting0.80798473
86MP0008872_abnormal_physiological_respon0.80594465
87MP0001485_abnormal_pinna_reflex0.80590016
88MP0004510_myositis0.78759336
89MP0008874_decreased_physiological_sensi0.76208253
90MP0005187_abnormal_penis_morphology0.75649861
91MP0004215_abnormal_myocardial_fiber0.73836610
92MP0004085_abnormal_heartbeat0.72011310
93MP0000026_abnormal_inner_ear0.67598934
94MP0002751_abnormal_autonomic_nervous0.67486392
95MP0002090_abnormal_vision0.66610592
96MP0005535_abnormal_body_temperature0.63436455
97MP0000604_amyloidosis0.63239319
98MP0001664_abnormal_digestion0.61734044
99MP0004484_altered_response_of0.61267707
100MP0003137_abnormal_impulse_conducting0.61035993
101MP0004043_abnormal_pH_regulation0.59483827
102MP0000015_abnormal_ear_pigmentation0.59396919
103MP0008004_abnormal_stomach_pH0.59271962
104MP0001943_abnormal_respiration0.57969405
105MP0001348_abnormal_lacrimal_gland0.57070867
106MP0005195_abnormal_posterior_eye0.56198161
107MP0010768_mortality/aging0.55083860
108MP0002082_postnatal_lethality0.54196797
109MP0000230_abnormal_systemic_arterial0.54157977
110MP0000569_abnormal_digit_pigmentation0.53613664
111MP0000013_abnormal_adipose_tissue0.53247302
112MP0004147_increased_porphyrin_level0.52180866
113MP0005410_abnormal_fertilization0.52169212
114MP0010769_abnormal_survival0.51855174
115MP0010770_preweaning_lethality0.51696797
116MP0001765_abnormal_ion_homeostasis0.51154179
117MP0005623_abnormal_meninges_morphology0.51133024
118MP0004036_abnormal_muscle_relaxation0.49019430
119MP0000579_abnormal_nail_morphology0.48578153
120MP0003956_abnormal_body_size0.48440786
121MP0004084_abnormal_cardiac_muscle0.45455098

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.48353266
2Myokymia (HP:0002411)6.13432596
3Focal seizures (HP:0007359)5.30522863
4Febrile seizures (HP:0002373)4.79684905
5Atonic seizures (HP:0010819)4.73345304
6Progressive cerebellar ataxia (HP:0002073)4.72546584
7Epileptic encephalopathy (HP:0200134)4.45367616
8Visual hallucinations (HP:0002367)4.29702278
9Action tremor (HP:0002345)4.10219534
10Absence seizures (HP:0002121)3.84428576
11Gaze-evoked nystagmus (HP:0000640)3.79968540
12Broad-based gait (HP:0002136)3.71535896
13Dialeptic seizures (HP:0011146)3.66744971
14Generalized tonic-clonic seizures (HP:0002069)3.47625216
15Supranuclear gaze palsy (HP:0000605)3.41836209
16Scanning speech (HP:0002168)3.37382076
17Dysdiadochokinesis (HP:0002075)3.20669703
18Ankle clonus (HP:0011448)3.20521793
19Truncal ataxia (HP:0002078)3.15577279
20Limb dystonia (HP:0002451)3.13296121
21Dysmetria (HP:0001310)3.09596413
22Progressive inability to walk (HP:0002505)3.05076885
23Depression (HP:0000716)3.02767640
24Abnormal eating behavior (HP:0100738)2.97385242
25Hyperventilation (HP:0002883)2.91450143
26Mutism (HP:0002300)2.91328099
27Anxiety (HP:0000739)2.91123980
28Agitation (HP:0000713)2.84157831
29Pheochromocytoma (HP:0002666)2.73597506
30Hypsarrhythmia (HP:0002521)2.71239133
31Cerebral hypomyelination (HP:0006808)2.68459855
32Urinary bladder sphincter dysfunction (HP:0002839)2.66426743
33Abnormality of the corticospinal tract (HP:0002492)2.61335922
34Poor eye contact (HP:0000817)2.58512092
35Spastic gait (HP:0002064)2.57563193
36Hemiparesis (HP:0001269)2.56889362
37Genetic anticipation (HP:0003743)2.55511900
38Morphological abnormality of the pyramidal tract (HP:0002062)2.49428056
39Neuroendocrine neoplasm (HP:0100634)2.47803732
40Impaired vibration sensation in the lower limbs (HP:0002166)2.43827612
41Neurofibrillary tangles (HP:0002185)2.43400446
42Postural instability (HP:0002172)2.42962218
43Absent speech (HP:0001344)2.39996604
44Diplopia (HP:0000651)2.39118408
45Abnormality of binocular vision (HP:0011514)2.39118408
46Abnormal social behavior (HP:0012433)2.36416804
47Impaired social interactions (HP:0000735)2.36416804
48Excessive salivation (HP:0003781)2.35496371
49Drooling (HP:0002307)2.35496371
50Fetal akinesia sequence (HP:0001989)2.33737498
51Peripheral hypomyelination (HP:0007182)2.33044450
52Insidious onset (HP:0003587)2.32763199
53Termporal pattern (HP:0011008)2.32763199
54Amblyopia (HP:0000646)2.29189112
55Polyphagia (HP:0002591)2.28773726
56Obstructive sleep apnea (HP:0002870)2.27505926
57Intention tremor (HP:0002080)2.26710390
58Inability to walk (HP:0002540)2.25439505
59Gait imbalance (HP:0002141)2.23914856
60Clonus (HP:0002169)2.21433704
61Delusions (HP:0000746)2.19057409
62Impaired smooth pursuit (HP:0007772)2.18450585
63Prolonged bleeding time (HP:0003010)2.17174256
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.15659477
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15659477
66Tetraplegia (HP:0002445)2.14874435
67Retinal dysplasia (HP:0007973)2.13908076
68Craniofacial dystonia (HP:0012179)2.13552368
69Blue irides (HP:0000635)2.12701039
70Hemiplegia (HP:0002301)2.12469524
71Urinary urgency (HP:0000012)2.11813895
72Menorrhagia (HP:0000132)2.08795424
73Torticollis (HP:0000473)2.07895025
74Ulnar claw (HP:0001178)2.06934704
75Spastic tetraplegia (HP:0002510)2.06559727
76Bradykinesia (HP:0002067)2.06089266
77Abnormal hair whorl (HP:0010721)2.05643194
78Amyotrophic lateral sclerosis (HP:0007354)2.04588960
79Papilledema (HP:0001085)2.04469033
80Generalized myoclonic seizures (HP:0002123)2.04142647
81Specific learning disability (HP:0001328)2.03494626
82Sensory axonal neuropathy (HP:0003390)2.01820658
83Esotropia (HP:0000565)1.99369280
84Increased mean platelet volume (HP:0011877)1.99169876
85Bradycardia (HP:0001662)1.98948338
86Spastic tetraparesis (HP:0001285)1.98768277
87Annular pancreas (HP:0001734)1.95969640
88Lower limb muscle weakness (HP:0007340)1.95441174
89Abnormality of ocular smooth pursuit (HP:0000617)1.94964181
90Protruding tongue (HP:0010808)1.94931131
91Rigidity (HP:0002063)1.94178031
92Psychosis (HP:0000709)1.94072675
93Ventricular fibrillation (HP:0001663)1.92998755
94Status epilepticus (HP:0002133)1.92925358
95Failure to thrive in infancy (HP:0001531)1.92826604
96Gait ataxia (HP:0002066)1.92584251
97Neuronal loss in central nervous system (HP:0002529)1.92203113
98Abnormality of saccadic eye movements (HP:0000570)1.90007521
99Epileptiform EEG discharges (HP:0011182)1.89865180
100Stereotypic behavior (HP:0000733)1.89663626
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89587819
102Medial flaring of the eyebrow (HP:0010747)1.89347129
103Megalencephaly (HP:0001355)1.89121851
104Cerebral inclusion bodies (HP:0100314)1.87927840
105Congenital primary aphakia (HP:0007707)1.86624007
106Focal dystonia (HP:0004373)1.86441198
107Central scotoma (HP:0000603)1.86347937
108Horizontal nystagmus (HP:0000666)1.86328457
109Alacrima (HP:0000522)1.86135090
110Postural tremor (HP:0002174)1.85966355
111Absent/shortened dynein arms (HP:0200106)1.85447990
112Dynein arm defect of respiratory motile cilia (HP:0012255)1.85447990
113Apathy (HP:0000741)1.84852651
114Abnormality of the lower motor neuron (HP:0002366)1.83688211
115Dysmetric saccades (HP:0000641)1.83358322
116Impaired vibratory sensation (HP:0002495)1.83258006
117Hypothermia (HP:0002045)1.82795025
118Sleep apnea (HP:0010535)1.82751340
119Paraplegia (HP:0010550)1.82470051
120EEG with generalized epileptiform discharges (HP:0011198)1.82465489
121Akinesia (HP:0002304)1.82102551
122Increased circulating renin level (HP:0000848)1.79957443
123Genital tract atresia (HP:0001827)1.78639233
124Split foot (HP:0001839)1.76936436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.15394721
2CASK4.05068054
3MAP2K73.09513444
4MAP3K42.93170911
5MARK12.91394108
6TNIK2.87194471
7MAP3K92.72074766
8EPHA42.58515885
9MAP3K122.48829513
10MINK12.44604673
11CDK192.02512706
12NTRK22.01178592
13NTRK11.85477502
14MAPK131.85021828
15PAK61.81825841
16MAP2K41.80987237
17FES1.69235740
18OXSR11.65760179
19PNCK1.58346057
20PRPF4B1.57086299
21GRK51.55741074
22DAPK21.55632238
23STK391.55079019
24UHMK11.51998986
25CAMKK21.51501460
26CDK51.42044766
27CAMKK11.31916074
28RIPK41.31293653
29STK381.22611302
30WNK11.21596683
31SGK2231.18705593
32SGK4941.18705593
33PHKG21.16519517
34PHKG11.16519517
35PLK21.16340744
36MUSK1.14034600
37CAMK2A1.13418858
38PRKCG1.07689354
39ARAF1.05175332
40CAMK2B1.04931250
41KSR21.04249583
42CSNK1G20.94692908
43PINK10.94524871
44PRKD30.94057280
45CAMK10.87937338
46SGK20.86710782
47CDK140.86207467
48MAPK120.84336289
49STK110.84262121
50MAPKAPK50.83208318
51PKN10.80055680
52NEK60.79996310
53SIK20.79584810
54CAMK2D0.79560975
55PDK10.79495443
56CDK180.77319158
57CCNB10.77313330
58CDK150.75377779
59DYRK1A0.72599455
60DAPK10.72296721
61CAMK2G0.71181187
62WNK40.68396545
63PRKCE0.67520792
64CDK11A0.67408205
65KSR10.67304262
66CAMK40.67108403
67FRK0.67064526
68TNK20.66837489
69MAP3K20.66346511
70AKT30.65752225
71BCR0.64887792
72MARK20.64754120
73TYRO30.64640245
74PRKCH0.64278094
75PTK2B0.63774089
76IRAK20.62776249
77BMPR20.61870227
78CSNK1G30.61687532
79LMTK20.61263651
80RET0.59869428
81FGFR20.59097900
82SGK10.58726558
83LIMK10.57406047
84ROCK20.57133817
85RIPK10.56188925
86LATS20.55714338
87FER0.55686498
88WNK30.53179208
89SGK30.52695932
90GRK70.52053545
91DYRK20.51392183
92PAK30.50505069
93ALK0.50135733
94CAMK1G0.49340268
95ADRBK20.47038953
96ADRBK10.46881496
97MAP3K130.46739679
98MAP3K10.46660122
99PRKCA0.44511753
100TRIM280.44132296
101MKNK20.43576699
102PRKACA0.43227952
103PRKCB0.43026190
104RAF10.43004902
105CSNK1D0.42837954
106FYN0.42568405
107FGR0.42444881
108CSNK1G10.41278109
109PRKG10.41059900
110BMX0.40408556
111MAPK100.40383052
112SYK0.40115305
113RPS6KA30.39874395
114NME10.39545750
115PDPK10.39086751
116BMPR1B0.38708426
117CSNK1A1L0.38494113
118PRKCZ0.38191867
119ERBB20.35496956
120MAP2K10.35038607
121CSNK1E0.32888442

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97695686
2* Synaptic vesicle cycle_Homo sapiens_hsa047213.43400858
3GABAergic synapse_Homo sapiens_hsa047272.92823896
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77757763
5Morphine addiction_Homo sapiens_hsa050322.66976039
6Glutamatergic synapse_Homo sapiens_hsa047242.63463532
7Olfactory transduction_Homo sapiens_hsa047402.55013364
8Circadian entrainment_Homo sapiens_hsa047132.54738973
9Long-term potentiation_Homo sapiens_hsa047202.27512598
10Amphetamine addiction_Homo sapiens_hsa050312.19199775
11Phototransduction_Homo sapiens_hsa047442.13890086
12Dopaminergic synapse_Homo sapiens_hsa047282.11708000
13Salivary secretion_Homo sapiens_hsa049702.08777853
14Taste transduction_Homo sapiens_hsa047422.07370758
15Serotonergic synapse_Homo sapiens_hsa047262.02696003
16Long-term depression_Homo sapiens_hsa047301.92136326
17Cholinergic synapse_Homo sapiens_hsa047251.90512700
18Insulin secretion_Homo sapiens_hsa049111.89906350
19Collecting duct acid secretion_Homo sapiens_hsa049661.87969470
20* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84555184
21Cocaine addiction_Homo sapiens_hsa050301.72116286
22Gastric acid secretion_Homo sapiens_hsa049711.70353347
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59242390
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58825846
25Renin secretion_Homo sapiens_hsa049241.55621616
26Calcium signaling pathway_Homo sapiens_hsa040201.49030550
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47298857
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45039637
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43955405
30Oxytocin signaling pathway_Homo sapiens_hsa049211.40531016
31Cardiac muscle contraction_Homo sapiens_hsa042601.31340492
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27768834
33Gap junction_Homo sapiens_hsa045401.27039500
34GnRH signaling pathway_Homo sapiens_hsa049121.25888259
35Axon guidance_Homo sapiens_hsa043601.24301722
36Vibrio cholerae infection_Homo sapiens_hsa051101.21731777
37Oxidative phosphorylation_Homo sapiens_hsa001901.17325675
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17061416
39cAMP signaling pathway_Homo sapiens_hsa040241.16260773
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11469921
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08230520
42Melanogenesis_Homo sapiens_hsa049160.94456561
43ErbB signaling pathway_Homo sapiens_hsa040120.94221564
44Platelet activation_Homo sapiens_hsa046110.94009637
45Alzheimers disease_Homo sapiens_hsa050100.93806691
46Type II diabetes mellitus_Homo sapiens_hsa049300.93245808
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91882708
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90437145
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.89733298
50Estrogen signaling pathway_Homo sapiens_hsa049150.87923015
51Nitrogen metabolism_Homo sapiens_hsa009100.86950014
52Parkinsons disease_Homo sapiens_hsa050120.85419584
53Pancreatic secretion_Homo sapiens_hsa049720.85381789
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85327004
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81914905
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78551562
57Bile secretion_Homo sapiens_hsa049760.78029483
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77662642
59* Phospholipase D signaling pathway_Homo sapiens_hsa040720.75480845
60Dorso-ventral axis formation_Homo sapiens_hsa043200.73963084
61Glioma_Homo sapiens_hsa052140.71893268
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71380549
63Thyroid hormone synthesis_Homo sapiens_hsa049180.69903685
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68932239
65MAPK signaling pathway_Homo sapiens_hsa040100.67038043
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64678083
67Ras signaling pathway_Homo sapiens_hsa040140.64111199
68Choline metabolism in cancer_Homo sapiens_hsa052310.63238049
69Type I diabetes mellitus_Homo sapiens_hsa049400.62428662
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61096059
71Ether lipid metabolism_Homo sapiens_hsa005650.59459178
72Oocyte meiosis_Homo sapiens_hsa041140.59059338
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.57231360
74Dilated cardiomyopathy_Homo sapiens_hsa054140.56843538
75Alcoholism_Homo sapiens_hsa050340.53356317
76Rheumatoid arthritis_Homo sapiens_hsa053230.52706920
77Inositol phosphate metabolism_Homo sapiens_hsa005620.52561691
78Ovarian steroidogenesis_Homo sapiens_hsa049130.51826413
79Fatty acid biosynthesis_Homo sapiens_hsa000610.51229694
80Huntingtons disease_Homo sapiens_hsa050160.50943010
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49090117
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47459426
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46914142
84Wnt signaling pathway_Homo sapiens_hsa043100.46142644
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43857915
86Rap1 signaling pathway_Homo sapiens_hsa040150.43285512
87Prion diseases_Homo sapiens_hsa050200.43237042
88Circadian rhythm_Homo sapiens_hsa047100.42629065
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42489227
90* Endocytosis_Homo sapiens_hsa041440.40053470
91Glucagon signaling pathway_Homo sapiens_hsa049220.38977113
92Sphingolipid metabolism_Homo sapiens_hsa006000.38361953
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.38024330
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37493570
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35722201
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35245912
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34930815
98mTOR signaling pathway_Homo sapiens_hsa041500.33296218
99Phagosome_Homo sapiens_hsa041450.31486398
100Renal cell carcinoma_Homo sapiens_hsa052110.30739381
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.30506222
102Mineral absorption_Homo sapiens_hsa049780.30134756
103Chemokine signaling pathway_Homo sapiens_hsa040620.30026739
104African trypanosomiasis_Homo sapiens_hsa051430.29570622
105Endometrial cancer_Homo sapiens_hsa052130.29212652
106Vitamin B6 metabolism_Homo sapiens_hsa007500.28793068
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27978185
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27096048
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25026465
110beta-Alanine metabolism_Homo sapiens_hsa004100.24987631
111Hedgehog signaling pathway_Homo sapiens_hsa043400.23685306
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22868560
113Melanoma_Homo sapiens_hsa052180.22417842
114Regulation of autophagy_Homo sapiens_hsa041400.22211582
115VEGF signaling pathway_Homo sapiens_hsa043700.22022355
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20870059
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20426267
118Tight junction_Homo sapiens_hsa045300.18018614
119AMPK signaling pathway_Homo sapiens_hsa041520.17137554

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