DNMBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07587861
2alpha-linolenic acid metabolic process (GO:0036109)4.88165670
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.72838284
4L-phenylalanine catabolic process (GO:0006559)4.72838284
5L-phenylalanine metabolic process (GO:0006558)4.58981993
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.58981993
7urea metabolic process (GO:0019627)4.57331649
8urea cycle (GO:0000050)4.57331649
9regulation of cholesterol homeostasis (GO:2000188)4.57298894
10skin morphogenesis (GO:0043589)4.47658599
11negative regulation of fibrinolysis (GO:0051918)4.40117922
12sulfur amino acid catabolic process (GO:0000098)4.30827772
13kynurenine metabolic process (GO:0070189)4.26283148
14high-density lipoprotein particle remodeling (GO:0034375)4.24790424
15aromatic amino acid family catabolic process (GO:0009074)4.23214465
16cell adhesion mediated by integrin (GO:0033627)4.17734784
17homocysteine metabolic process (GO:0050667)4.16716733
18positive regulation of fatty acid beta-oxidation (GO:0032000)4.14306702
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08859910
20intestinal cholesterol absorption (GO:0030299)4.07511844
21regulation of triglyceride catabolic process (GO:0010896)4.07202560
22protein carboxylation (GO:0018214)4.06318543
23peptidyl-glutamic acid carboxylation (GO:0017187)4.06318543
24regulation of protein activation cascade (GO:2000257)4.02976534
25nitrogen cycle metabolic process (GO:0071941)4.02217459
26nuclear pore complex assembly (GO:0051292)3.99864847
27phospholipid homeostasis (GO:0055091)3.99508741
28negative regulation of cholesterol transport (GO:0032375)3.98297562
29negative regulation of sterol transport (GO:0032372)3.98297562
30reverse cholesterol transport (GO:0043691)3.97771677
31mitotic chromosome condensation (GO:0007076)3.96217641
32cysteine metabolic process (GO:0006534)3.93836215
33hemidesmosome assembly (GO:0031581)3.92644691
34bile acid biosynthetic process (GO:0006699)3.90471470
35regulation of fatty acid beta-oxidation (GO:0031998)3.88889795
36indole-containing compound catabolic process (GO:0042436)3.88443697
37indolalkylamine catabolic process (GO:0046218)3.88443697
38tryptophan catabolic process (GO:0006569)3.88443697
39regulation of fibrinolysis (GO:0051917)3.88243169
40complement activation, alternative pathway (GO:0006957)3.88240438
41regulation of bile acid biosynthetic process (GO:0070857)3.87935849
42lysine catabolic process (GO:0006554)3.87264751
43lysine metabolic process (GO:0006553)3.87264751
44bile acid and bile salt transport (GO:0015721)3.81947437
45triglyceride homeostasis (GO:0070328)3.79661666
46acylglycerol homeostasis (GO:0055090)3.79661666
47glyoxylate metabolic process (GO:0046487)3.79319113
48regulation of complement activation (GO:0030449)3.79066895
49mesodermal cell differentiation (GO:0048333)3.78732555
50amino-acid betaine metabolic process (GO:0006577)3.74740471
51Golgi transport vesicle coating (GO:0048200)3.71143837
52COPI coating of Golgi vesicle (GO:0048205)3.71143837
53tryptophan metabolic process (GO:0006568)3.70400693
54phospholipid efflux (GO:0033700)3.69979231
55heterochromatin organization (GO:0070828)3.67328589
56bile acid metabolic process (GO:0008206)3.66718422
57notochord development (GO:0030903)3.64454276
58serine family amino acid catabolic process (GO:0009071)3.64230169
59plasma lipoprotein particle assembly (GO:0034377)3.60994992
60protein-lipid complex remodeling (GO:0034368)3.60952982
61macromolecular complex remodeling (GO:0034367)3.60952982
62plasma lipoprotein particle remodeling (GO:0034369)3.60952982
63paraxial mesoderm development (GO:0048339)3.60530887
64ethanol oxidation (GO:0006069)3.56006045
65positive regulation of lipid catabolic process (GO:0050996)3.55116185
66hypotonic response (GO:0006971)3.50779153
67protein-lipid complex assembly (GO:0065005)3.49152150
68hippo signaling (GO:0035329)3.48962198
69plasma lipoprotein particle clearance (GO:0034381)3.47323503
70glomerular visceral epithelial cell development (GO:0072015)3.40817602
71cellular glucuronidation (GO:0052695)3.40700041
72retina vasculature morphogenesis in camera-type eye (GO:0061299)3.39891416
73regulation of cholesterol esterification (GO:0010872)3.39780814
74cell-substrate junction assembly (GO:0007044)3.39597026
75dicarboxylic acid biosynthetic process (GO:0043650)3.38500251
76lipoprotein metabolic process (GO:0042157)3.38333553
772-oxoglutarate metabolic process (GO:0006103)3.38243778
78glycine metabolic process (GO:0006544)3.38091068
79regulation of transforming growth factor beta2 production (GO:0032909)3.34579525
80cholesterol efflux (GO:0033344)3.33760588
81midgut development (GO:0007494)3.32319589
82intestinal absorption (GO:0050892)3.28448898
83cellular modified amino acid catabolic process (GO:0042219)3.24706348
84cholesterol homeostasis (GO:0042632)3.23579925
85negative regulation of chondrocyte differentiation (GO:0032331)3.21105641
86alpha-amino acid catabolic process (GO:1901606)3.20888892
87epithelial cell-cell adhesion (GO:0090136)3.20545034
88sterol homeostasis (GO:0055092)3.19338563
89positive regulation of lipoprotein lipase activity (GO:0051006)3.18579743
90positive regulation of triglyceride lipase activity (GO:0061365)3.18579743
91nuclear pore organization (GO:0006999)3.16459339
92positive regulation of triglyceride metabolic process (GO:0090208)3.16287996
93positive regulation of fatty acid oxidation (GO:0046321)3.13727425
94glomerular epithelial cell development (GO:0072310)3.11435410
95very-low-density lipoprotein particle assembly (GO:0034379)3.11389075
96focal adhesion assembly (GO:0048041)3.10452500
97cell-substrate adherens junction assembly (GO:0007045)3.10452500
98adherens junction assembly (GO:0034333)3.10150035
99negative regulation of DNA repair (GO:0045738)3.09233511
100activation of Rac GTPase activity (GO:0032863)3.07335287
101substrate-dependent cell migration (GO:0006929)3.04750362
102valine metabolic process (GO:0006573)3.02710996
103SMAD protein complex assembly (GO:0007183)3.01120129
104desmosome organization (GO:0002934)3.00436459
105drug catabolic process (GO:0042737)2.98584138
106muscle cell migration (GO:0014812)2.98100580
107serine family amino acid metabolic process (GO:0009069)2.97433840
108embryonic retina morphogenesis in camera-type eye (GO:0060059)2.96147311
109glutamate metabolic process (GO:0006536)2.95569874
110cellular amino acid catabolic process (GO:0009063)2.95191611
111plasma lipoprotein particle organization (GO:0071827)2.95188109
112tyrosine metabolic process (GO:0006570)2.92738846
113protein-lipid complex subunit organization (GO:0071825)2.92557226
114negative regulation of lipase activity (GO:0060192)2.91719332
115serine family amino acid biosynthetic process (GO:0009070)2.91334617
116negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.90742016
117aromatic amino acid family metabolic process (GO:0009072)2.90492974
118protein localization to endosome (GO:0036010)2.89526026
119ethanol metabolic process (GO:0006067)2.88562996
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87873101
121negative regulation of fatty acid transport (GO:2000192)2.86738434
122carnitine metabolic process (GO:0009437)2.85987307
123COPII vesicle coating (GO:0048208)2.85936434
124lipid homeostasis (GO:0055088)2.85006812
125chondrocyte proliferation (GO:0035988)2.84239511
126endothelial cell morphogenesis (GO:0001886)2.83726222
127negative regulation of lipid transport (GO:0032369)2.83534819
128dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83058153
129imidazole-containing compound metabolic process (GO:0052803)2.80818595
130primary alcohol catabolic process (GO:0034310)2.80531348
131DNA unwinding involved in DNA replication (GO:0006268)2.80502977
132fatty acid transmembrane transport (GO:1902001)2.79860515
133epoxygenase P450 pathway (GO:0019373)2.79685586
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78872959
135fatty acid beta-oxidation (GO:0006635)2.77510424
136fatty acid oxidation (GO:0019395)2.77154561
137cell migration involved in sprouting angiogenesis (GO:0002042)2.76881204
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76854486
139low-density lipoprotein particle clearance (GO:0034383)2.76444434
140coenzyme catabolic process (GO:0009109)2.74742926
141endocardial cushion development (GO:0003197)2.74333762
142mitotic sister chromatid cohesion (GO:0007064)2.74142459
143pore complex assembly (GO:0046931)2.73413137
144bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70265376
145cellular response to vitamin D (GO:0071305)2.69381103
146mitotic cytokinesis (GO:0000281)2.69149004
147negative regulation of anoikis (GO:2000811)2.68867979
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68395959
149barbed-end actin filament capping (GO:0051016)2.67530725
150wound healing, spreading of epidermal cells (GO:0035313)2.65017643
151positive regulation of Rho protein signal transduction (GO:0035025)2.63941896
152cellular protein complex localization (GO:0034629)2.63486424
153cellular response to vitamin (GO:0071295)2.61565744
154branching involved in mammary gland duct morphogenesis (GO:0060444)2.60927429
155UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58413829
156mitotic sister chromatid segregation (GO:0000070)2.56346283
157regulation of mitotic spindle organization (GO:0060236)2.55470451
158plasma membrane repair (GO:0001778)2.53907516
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.53829803
160regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.52994219
161blood vessel endothelial cell migration (GO:0043534)2.52528976
162gap junction assembly (GO:0016264)2.52187223
163branching involved in salivary gland morphogenesis (GO:0060445)2.51453403
164positive regulation of SMAD protein import into nucleus (GO:0060391)2.49972735
165nucleotide-sugar biosynthetic process (GO:0009226)2.49148434
166regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48597073
167embryonic process involved in female pregnancy (GO:0060136)2.47822503
168wound healing, spreading of cells (GO:0044319)2.47695950
169morphogenesis of an epithelial sheet (GO:0002011)2.47659988
170negative regulation of stem cell proliferation (GO:2000647)2.47049129
171establishment of integrated proviral latency (GO:0075713)2.46104417
172regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.45647968
173mitotic metaphase plate congression (GO:0007080)2.44422327
174atrioventricular valve morphogenesis (GO:0003181)2.44395841
175mammary gland epithelial cell proliferation (GO:0033598)2.44314240
176response to hepatocyte growth factor (GO:0035728)2.43865963
177cellular response to hepatocyte growth factor stimulus (GO:0035729)2.43865963
178membrane raft organization (GO:0031579)2.42798401
179regulation of RNA export from nucleus (GO:0046831)2.42759329
180lung vasculature development (GO:0060426)2.41794425
181negative regulation of keratinocyte proliferation (GO:0010839)2.41458340
182actin filament depolymerization (GO:0030042)2.41272596
183endodermal cell differentiation (GO:0035987)2.41140394
184protein localization to chromosome, centromeric region (GO:0071459)2.38817165
185regulation of cardioblast differentiation (GO:0051890)2.38408162
186pericardium development (GO:0060039)2.37609699
187positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37310666
188embryonic foregut morphogenesis (GO:0048617)2.37257980
189mammary gland development (GO:0030879)2.37206561
190sister chromatid segregation (GO:0000819)2.36762268
191cytoskeleton-dependent cytokinesis (GO:0061640)2.36360460
192tight junction assembly (GO:0070830)2.33570392
193bone remodeling (GO:0046849)2.33500481
194stress fiber assembly (GO:0043149)2.33420885
195maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.30234587
196cell-cell junction assembly (GO:0007043)2.29208667
197regulation of spindle organization (GO:0090224)2.29061442
198positive regulation of endothelial cell apoptotic process (GO:2000353)2.27063936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.71056635
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.62501468
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.13739074
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.68903482
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.69197721
6E2F7_22180533_ChIP-Seq_HELA_Human3.66833224
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53044250
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.36962269
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.27458363
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.22804946
11CLOCK_20551151_ChIP-Seq_293T_Human3.06158972
12TP63_17297297_ChIP-ChIP_HaCaT_Human3.01806386
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71622763
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.57436749
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13796128
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12226690
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10673900
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06016059
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05107929
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.96553353
21BRD4_25478319_ChIP-Seq_HGPS_Human1.96172626
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.92140887
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89315451
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.80980943
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.78944245
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76427166
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.74152192
28EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.65822000
29SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62471531
30* UBF1/2_26484160_Chip-Seq_HMECs_Human1.60184771
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59657993
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58307483
33* CJUN_26792858_Chip-Seq_BT549_Human1.56299634
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.54826086
35* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.54740514
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52914174
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.51746143
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49449425
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.46643442
40* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45768070
41* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43665455
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43171663
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.42664327
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40628026
45NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.39920585
46GATA6_25053715_ChIP-Seq_YYC3_Human1.38758671
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38259960
48GATA4_25053715_ChIP-Seq_YYC3_Human1.37404727
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37234309
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36793695
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34119187
52ZNF263_19887448_ChIP-Seq_K562_Human1.33281643
53GATA1_22025678_ChIP-Seq_K562_Human1.31676675
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29605915
55ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28924768
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28827574
57TP53_22127205_ChIP-Seq_IMR90_Human1.28594577
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28582750
59TCF7_22412390_ChIP-Seq_EML_Mouse1.27722893
60ATF3_27146783_Chip-Seq_COLON_Human1.26286674
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25668940
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.25398118
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.24798583
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24696512
65* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24263225
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24020191
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22279339
68MYC_22102868_ChIP-Seq_BL_Human1.21202567
69* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20186483
70* ELK3_25401928_ChIP-Seq_HUVEC_Human1.19907728
71AR_21909140_ChIP-Seq_LNCAP_Human1.18421160
72CHD1_26751641_Chip-Seq_LNCaP_Human1.18328503
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17759287
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.17521175
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16352902
76TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16257938
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15307962
78RACK7_27058665_Chip-Seq_MCF-7_Human1.14939980
79TP53_16413492_ChIP-PET_HCT116_Human1.12456394
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11998537
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10213162
82ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09882633
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09845183
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09814135
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07855370
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07855370
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07443871
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06626764
89* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06431571
90SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06282676
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.05560936
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.05560936
93* AHR_22903824_ChIP-Seq_MCF-7_Human1.05329037
94LXR_22292898_ChIP-Seq_THP-1_Human1.05179445
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05127263
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04621211
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04375974
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.03839840
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03461532
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02849293
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02704575
102* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02417103
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02075254
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01866026
105KDM2B_26808549_Chip-Seq_DND41_Human1.01818386
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.01757543
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01521090
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00345178
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99782849
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99030199
111* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98776732
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98140906
113TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97799840
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97103234
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95674365
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.95545676
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95361093
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95112404
119* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94749918
120E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94392349
121* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93333521
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92999747
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92961156
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90471204
125GATA2_21666600_ChIP-Seq_HMVEC_Human0.88539937
126CREB1_26743006_Chip-Seq_LNCaP_Human0.88359256
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87968170
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86388515
129BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86057712
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84645742
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.84376807
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84035538
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82684518
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82399867
135NCOR1_26117541_ChIP-Seq_K562_Human0.81324425
136* ISL1_27105846_Chip-Seq_CPCs_Mouse0.81294522
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81067064
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80206522
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79565589
140GATA2_19941826_ChIP-Seq_K562_Human0.78546323
141SOX2_20726797_ChIP-Seq_SW620_Human0.77579856
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77486593
143* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.76780927
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.75811671
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.75048416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.71176830
2MP0005360_urolithiasis5.67078309
3MP0005365_abnormal_bile_salt4.77495474
4MP0005085_abnormal_gallbladder_physiolo4.69632434
5MP0003252_abnormal_bile_duct3.57671138
6MP0008875_abnormal_xenobiotic_pharmacok3.52249494
7MP0003705_abnormal_hypodermis_morpholog3.44775627
8MP0010329_abnormal_lipoprotein_level2.77686380
9MP0009840_abnormal_foam_cell2.76463812
10MP0001666_abnormal_nutrient_absorption2.70838492
11MP0010234_abnormal_vibrissa_follicle2.68957328
12MP0003806_abnormal_nucleotide_metabolis2.56655945
13MP0003950_abnormal_plasma_membrane2.44223925
14MP0003941_abnormal_skin_development2.35853420
15MP0002877_abnormal_melanocyte_morpholog2.30141629
16MP0005083_abnormal_biliary_tract2.15600601
17MP0005670_abnormal_white_adipose2.06451991
18MP0005623_abnormal_meninges_morphology1.95696734
19MP0002796_impaired_skin_barrier1.80256594
20MP0000609_abnormal_liver_physiology1.74787159
21MP0010352_gastrointestinal_tract_polyps1.65973006
22MP0003300_gastrointestinal_ulcer1.63073472
23MP0005332_abnormal_amino_acid1.62794736
24MP0004019_abnormal_vitamin_homeostasis1.60616985
25MP0010368_abnormal_lymphatic_system1.58449981
26MP0008438_abnormal_cutaneous_collagen1.56472819
27MP0005409_darkened_coat_color1.55239734
28MP0006054_spinal_hemorrhage1.53983030
29MP0005501_abnormal_skin_physiology1.52599314
30MP0003191_abnormal_cellular_cholesterol1.52531662
31MP0004957_abnormal_blastocyst_morpholog1.52188154
32MP0004264_abnormal_extraembryonic_tissu1.51722268
33MP0008057_abnormal_DNA_replication1.48479802
34MP0003868_abnormal_feces_composition1.43571238
35MP0002118_abnormal_lipid_homeostasis1.41796149
36MP0000762_abnormal_tongue_morphology1.40376476
37MP0003693_abnormal_embryo_hatching1.40083919
38MP0005319_abnormal_enzyme/_coenzyme1.35598643
39MP0005076_abnormal_cell_differentiation1.34290668
40MP0000751_myopathy1.32419671
41MP0001299_abnormal_eye_distance/1.31576580
42MP0000428_abnormal_craniofacial_morphol1.31208246
43MP0009384_cardiac_valve_regurgitation1.28697170
44MP0003566_abnormal_cell_adhesion1.27814742
45MP0001730_embryonic_growth_arrest1.26386031
46MP0000749_muscle_degeneration1.25639746
47MP0000537_abnormal_urethra_morphology1.24032932
48MP0005023_abnormal_wound_healing1.21622402
49MP0009053_abnormal_anal_canal1.20999965
50MP0002138_abnormal_hepatobiliary_system1.19935813
51MP0005220_abnormal_exocrine_pancreas1.16606764
52MP0002254_reproductive_system_inflammat1.16344139
53MP0005248_abnormal_Harderian_gland1.15782855
54MP0001672_abnormal_embryogenesis/_devel1.15250740
55MP0005380_embryogenesis_phenotype1.15250740
56MP0003077_abnormal_cell_cycle1.15213772
57MP0003279_aneurysm1.13364805
58MP0002084_abnormal_developmental_patter1.12073364
59MP0000598_abnormal_liver_morphology1.09251946
60MP0003111_abnormal_nucleus_morphology1.07507215
61MP0002060_abnormal_skin_morphology1.06928892
62MP0009278_abnormal_bone_marrow1.06657782
63MP0001879_abnormal_lymphatic_vessel1.06039393
64MP0002085_abnormal_embryonic_tissue1.05688184
65MP0002697_abnormal_eye_size1.05547644
66MP0003937_abnormal_limbs/digits/tail_de1.04889439
67MP0001915_intracranial_hemorrhage1.02875451
68MP0008961_abnormal_basal_metabolism1.02653963
69MP0000534_abnormal_ureter_morphology1.02252212
70MP0005167_abnormal_blood-brain_barrier1.02179961
71MP0000432_abnormal_head_morphology1.01532676
72MP0009780_abnormal_chondrocyte_physiolo0.99069177
73MP0004272_abnormal_basement_membrane0.98865825
74MP0004858_abnormal_nervous_system0.98608436
75MP0000350_abnormal_cell_proliferation0.98259861
76MP0001216_abnormal_epidermal_layer0.98198216
77MP0005666_abnormal_adipose_tissue0.98081612
78MP0008932_abnormal_embryonic_tissue0.95550913
79MP0005621_abnormal_cell_physiology0.95437281
80MP0010030_abnormal_orbit_morphology0.95359022
81MP0002233_abnormal_nose_morphology0.94903562
82MP0002928_abnormal_bile_duct0.94352036
83MP0000467_abnormal_esophagus_morphology0.94328669
84MP0003828_pulmonary_edema0.93874656
85MP0004130_abnormal_muscle_cell0.93484749
86MP0001697_abnormal_embryo_size0.91471453
87MP0002080_prenatal_lethality0.90880876
88MP0001849_ear_inflammation0.90100288
89MP0003935_abnormal_craniofacial_develop0.90004220
90MP0006138_congestive_heart_failure0.89384228
91MP0003115_abnormal_respiratory_system0.88260231
92MP0001293_anophthalmia0.88125078
93MP0010094_abnormal_chromosome_stability0.87848980
94MP0004510_myositis0.87242126
95MP0005503_abnormal_tendon_morphology0.87107184
96MP0003385_abnormal_body_wall0.86765456
97MP0009643_abnormal_urine_homeostasis0.85998470
98MP0003195_calcinosis0.85651028
99MP0008007_abnormal_cellular_replicative0.82722246
100MP0000490_abnormal_crypts_of0.82427587
101MP0003755_abnormal_palate_morphology0.82042774
102MP0000383_abnormal_hair_follicle0.82007004
103MP0005508_abnormal_skeleton_morphology0.81974241
104MP0000569_abnormal_digit_pigmentation0.79940577
105MP0004087_abnormal_muscle_fiber0.79882580
106MP0005275_abnormal_skin_tensile0.79785962
107MP0005451_abnormal_body_composition0.79699315
108MP0001614_abnormal_blood_vessel0.79688258
109MP0000566_synostosis0.79191269
110MP0001764_abnormal_homeostasis0.77851108
111MP0005197_abnormal_uvea_morphology0.76483162
112MP0010678_abnormal_skin_adnexa0.76052842
113MP0005187_abnormal_penis_morphology0.75555717
114MP0000627_abnormal_mammary_gland0.75443166
115MP0003011_delayed_dark_adaptation0.74062130
116MP0009763_increased_sensitivity_to0.71760276
117MP0000733_abnormal_muscle_development0.67382038
118MP0005375_adipose_tissue_phenotype0.66847603
119MP0010630_abnormal_cardiac_muscle0.66413701
120MP0002269_muscular_atrophy0.65574687
121MP0002092_abnormal_eye_morphology0.65241615
122MP0009672_abnormal_birth_weight0.64911858
123MP0005584_abnormal_enzyme/coenzyme_acti0.64350514
124MP0002089_abnormal_postnatal_growth/wei0.63398295
125MP0000767_abnormal_smooth_muscle0.63369630
126MP0001958_emphysema0.61965455
127MP0001243_abnormal_dermal_layer0.61360068
128MP0002086_abnormal_extraembryonic_tissu0.61184105
129MP0004197_abnormal_fetal_growth/weight/0.61070912
130MP0009697_abnormal_copulation0.60154543
131MP0003453_abnormal_keratinocyte_physiol0.59898385
132MP0010307_abnormal_tumor_latency0.56772552
133MP0003045_fibrosis0.56086133
134MP0004947_skin_inflammation0.55990517
135MP0002090_abnormal_vision0.55915797
136MP0005334_abnormal_fat_pad0.55796793
137MP0002896_abnormal_bone_mineralization0.55755712
138MP0003091_abnormal_cell_migration0.55162987
139MP0002128_abnormal_blood_circulation0.55088244
140MP0004233_abnormal_muscle_weight0.55081627
141MP0003567_abnormal_fetal_cardiomyocyte0.55079172
142MP0005193_abnormal_anterior_eye0.54457779
143MP0004185_abnormal_adipocyte_glucose0.53988139
144MP0009115_abnormal_fat_cell0.52994120
145MP0000477_abnormal_intestine_morphology0.52655941
146MP0001873_stomach_inflammation0.52610262
147MP0002088_abnormal_embryonic_growth/wei0.52489946
148MP0002971_abnormal_brown_adipose0.51077012
149MP0005257_abnormal_intraocular_pressure0.50578105
150MP0003984_embryonic_growth_retardation0.50476704
151MP0009642_abnormal_blood_homeostasis0.50121815
152MP0002925_abnormal_cardiovascular_devel0.49711657
153MP0002168_other_aberrant_phenotype0.49595382
154MP0002078_abnormal_glucose_homeostasis0.47288823

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.35461784
2Intrahepatic cholestasis (HP:0001406)5.15112337
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.70373019
4Xanthomatosis (HP:0000991)4.64899590
5Hypobetalipoproteinemia (HP:0003563)4.48322202
6Hypolipoproteinemia (HP:0010981)3.80273354
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.79112156
8Hypoalphalipoproteinemia (HP:0003233)3.64114561
9Short nail (HP:0001799)3.64057445
10Complement deficiency (HP:0004431)3.46510022
11Arterial tortuosity (HP:0005116)3.36455434
12Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35074491
13Hyperlipoproteinemia (HP:0010980)3.32759670
14Epidermoid cyst (HP:0200040)3.31080936
15Abnormality of sulfur amino acid metabolism (HP:0004339)3.30869972
16Vascular tortuosity (HP:0004948)3.30445200
17Prolonged partial thromboplastin time (HP:0003645)3.25558124
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23879185
19Osteolytic defects of the hand bones (HP:0009699)3.23682276
20Osteolytic defects of the phalanges of the hand (HP:0009771)3.23682276
21Myocardial infarction (HP:0001658)3.19718377
22Abnormality of the common coagulation pathway (HP:0010990)3.15464040
23Hypercholesterolemia (HP:0003124)3.12334118
24Fat malabsorption (HP:0002630)2.97034863
25Cervical subluxation (HP:0003308)2.95549697
26Hyperammonemia (HP:0001987)2.95019970
27Hepatocellular carcinoma (HP:0001402)2.91706337
28Spastic diplegia (HP:0001264)2.89706271
29Spinal rigidity (HP:0003306)2.83196493
30Atrophic scars (HP:0001075)2.80912503
31Protrusio acetabuli (HP:0003179)2.74348300
32Esophageal varix (HP:0002040)2.73349864
33Hypoglycemic coma (HP:0001325)2.73248745
34Abnormality of the intrinsic pathway (HP:0010989)2.68585161
35Abnormality of complement system (HP:0005339)2.67352684
36Ketosis (HP:0001946)2.64261708
37Neonatal short-limb short stature (HP:0008921)2.63772047
38Right ventricular cardiomyopathy (HP:0011663)2.62554496
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.62250041
40Fragile skin (HP:0001030)2.60060189
41Abnormality of pyrimidine metabolism (HP:0004353)2.59291086
42Broad face (HP:0000283)2.58447211
43Abnormality of methionine metabolism (HP:0010901)2.55613600
44Increased connective tissue (HP:0009025)2.51676911
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.50090443
46Natal tooth (HP:0000695)2.47163006
47Skin nodule (HP:0200036)2.47071666
48Peritonitis (HP:0002586)2.44383176
49Vertebral arch anomaly (HP:0008438)2.41890144
50Hyperglycinuria (HP:0003108)2.40872756
51Conjugated hyperbilirubinemia (HP:0002908)2.40144976
52Aortic aneurysm (HP:0004942)2.39339819
53Cerebral aneurysm (HP:0004944)2.37703825
54Syringomyelia (HP:0003396)2.34434850
55Spinal cord lesions (HP:0100561)2.34434850
56Distal lower limb amyotrophy (HP:0008944)2.34354589
57Wormian bones (HP:0002645)2.33880713
58Entropion (HP:0000621)2.33466603
59Joint hemorrhage (HP:0005261)2.31823389
60Hyperglycinemia (HP:0002154)2.30206779
61Abnormality of the distal phalanges of the toes (HP:0010182)2.25447994
62Abnormality of glycine metabolism (HP:0010895)2.24534066
63Abnormality of serine family amino acid metabolism (HP:0010894)2.24534066
64Aneurysm (HP:0002617)2.17527503
65Malnutrition (HP:0004395)2.17081820
66Alopecia of scalp (HP:0002293)2.16556243
67Mitral stenosis (HP:0001718)2.14570627
68Abnormality of nucleobase metabolism (HP:0010932)2.13281014
69Abnormality of carpal bone ossification (HP:0006257)2.12719302
70Urethral obstruction (HP:0000796)2.11256964
71Ankle contracture (HP:0006466)2.10762604
72Abnormal ossification of hand bones (HP:0005921)2.10742374
73Premature rupture of membranes (HP:0001788)2.09234139
74Pigmentary retinal degeneration (HP:0001146)2.08429247
75Ankyloglossia (HP:0010296)2.08056196
76Vertebral compression fractures (HP:0002953)2.07741299
77Deviation of the thumb (HP:0009603)2.06794136
78Mildly elevated creatine phosphokinase (HP:0008180)2.05142100
79Abnormality of the lower motor neuron (HP:0002366)2.02767099
80Abnormality of oral frenula (HP:0000190)2.00729193
81Abnormality of fatty-acid metabolism (HP:0004359)1.98538923
82Aortic dissection (HP:0002647)1.98309593
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98172904
84Mitral valve prolapse (HP:0001634)1.95965398
85Increased mean platelet volume (HP:0011877)1.95905202
86Bladder diverticulum (HP:0000015)1.93957971
87Shallow orbits (HP:0000586)1.92369479
88Subacute progressive viral hepatitis (HP:0006572)1.91829400
89Absent frontal sinuses (HP:0002688)1.91708470
90Turricephaly (HP:0000262)1.91110855
91Abnormality of proline metabolism (HP:0010907)1.90349612
92Hydroxyprolinuria (HP:0003080)1.90349612
93Abnormality of purine metabolism (HP:0004352)1.90275978
94Selective tooth agenesis (HP:0001592)1.89871561
95Cardiovascular calcification (HP:0011915)1.89378318
96Hypoglycemic seizures (HP:0002173)1.88639501
97Renovascular hypertension (HP:0100817)1.87992995
98Reduced subcutaneous adipose tissue (HP:0003758)1.87973865
99Acanthocytosis (HP:0001927)1.87520719
100Abnormality of dentin (HP:0010299)1.87008747
101Lymphangioma (HP:0100764)1.86843188
102Pseudobulbar signs (HP:0002200)1.86268219
103Blue sclerae (HP:0000592)1.86122724
104Ketoacidosis (HP:0001993)1.85791324
105Nuclear cataract (HP:0100018)1.85578527
106Vertebral clefting (HP:0008428)1.84650368
107Spondylolisthesis (HP:0003302)1.84566133
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84543103
109Joint laxity (HP:0001388)1.84177176
110Broad metatarsal (HP:0001783)1.83204506
111Difficulty climbing stairs (HP:0003551)1.82385396
112Chorioretinal atrophy (HP:0000533)1.82343943
113Mitral regurgitation (HP:0001653)1.81881166
114Abnormal vertebral ossification (HP:0100569)1.81485663
115Abnormality of the acetabulum (HP:0003170)1.81341296
116Steatorrhea (HP:0002570)1.81166028
117Vascular calcification (HP:0004934)1.80177519
118Back pain (HP:0003418)1.78982610
119Hyperglycemia (HP:0003074)1.78875864
120Hyperacusis (HP:0010780)1.78697775
121Flat acetabular roof (HP:0003180)1.78556073
122Bronchomalacia (HP:0002780)1.77602559
123Disproportionate tall stature (HP:0001519)1.77099541
124Distal lower limb muscle weakness (HP:0009053)1.76405878
125Soft skin (HP:0000977)1.76325530
126Hemorrhage of the eye (HP:0011885)1.76106800
127Stroke (HP:0001297)1.74790650
128Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74622203
129Enlarged kidneys (HP:0000105)1.74139267
130Spontaneous abortion (HP:0005268)1.73891674
131Abnormality of the phalanges of the hallux (HP:0010057)1.72414151
132Elbow flexion contracture (HP:0002987)1.72091144
133Long eyelashes (HP:0000527)1.71887849
134Long toe (HP:0010511)1.71517648
135Upper motor neuron abnormality (HP:0002127)1.71232859
136Dilatation of the ascending aorta (HP:0005111)1.70508380
137Ectopia lentis (HP:0001083)1.70210339
138Focal segmental glomerulosclerosis (HP:0000097)1.69748679
139Hyperbilirubinemia (HP:0002904)1.69123215
140Abnormal hand bone ossification (HP:0010660)1.68582279
141Tibial bowing (HP:0002982)1.68211323
142Abnormal platelet volume (HP:0011876)1.67922464
143Arnold-Chiari malformation (HP:0002308)1.66896604
144Flattened epiphyses (HP:0003071)1.66807694
145Microglossia (HP:0000171)1.66186521
146Achilles tendon contracture (HP:0001771)1.65478355
147Advanced eruption of teeth (HP:0006288)1.65442549
148Abnormality of the 4th metacarpal (HP:0010012)1.65283174
149Gastrointestinal carcinoma (HP:0002672)1.64554102
150Malignant gastrointestinal tract tumors (HP:0006749)1.64554102
151Hand muscle atrophy (HP:0009130)1.63169665
152Aortic regurgitation (HP:0001659)1.63029334
153Proximal placement of thumb (HP:0009623)1.62396268
154Upper limb amyotrophy (HP:0009129)1.61343981
155Distal upper limb amyotrophy (HP:0007149)1.61343981
156Lower limb amyotrophy (HP:0007210)1.61199863
157Trismus (HP:0000211)1.60685424
158Thoracolumbar scoliosis (HP:0002944)1.60361279
159Nephritis (HP:0000123)1.60331529
160Late onset (HP:0003584)1.59703680
161Striae distensae (HP:0001065)1.59270922
162Missing ribs (HP:0000921)1.58618764
163Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.58394205
164Ulnar bowing (HP:0003031)1.58363182
165Thin bony cortex (HP:0002753)1.57969967
166Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57442234
167Long palpebral fissure (HP:0000637)1.55126147
168Abdominal distention (HP:0003270)1.53651724
169Vertebral hypoplasia (HP:0008417)1.53438133
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.53438133
171Cholelithiasis (HP:0001081)1.52935815
172Abnormal gallbladder physiology (HP:0012438)1.52838596
173Tetraparesis (HP:0002273)1.52564790
174Midface retrusion (HP:0011800)1.51580196
175Pterygium (HP:0001059)1.51433432
176Genu recurvatum (HP:0002816)1.51170218
177Skull defect (HP:0001362)1.50928299
178Glucose intolerance (HP:0000833)1.50440866
179Aplasia involving bones of the extremities (HP:0009825)1.50165320
180Aplasia involving bones of the upper limbs (HP:0009823)1.50165320
181Aplasia of the phalanges of the hand (HP:0009802)1.50165320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.48749815
2ERN13.27520830
3PKN23.20071186
4TRIB32.81580275
5PTK62.67389395
6LATS12.63709362
7CDK122.55374473
8TTN2.53590985
9RIPK12.53121053
10TAOK22.42444877
11BCKDK2.39010072
12FRK2.22208011
13MAP3K102.13954602
14NEK12.11953918
15FGFR42.01543213
16CAMK1D1.99403164
17EPHA21.95760539
18STK38L1.94706714
19SMG11.91316505
20EEF2K1.80570021
21PBK1.79377921
22PAK41.58823701
23PDGFRA1.53176442
24CDK61.51371911
25MST41.51312345
26BUB11.50113546
27AKT31.41516250
28DDR21.35197114
29CAMK1G1.34579675
30MAP3K71.33222390
31MTOR1.30107084
32TAOK31.29436004
33ICK1.29358782
34FLT31.29246773
35PNCK1.25596812
36PTK21.24966766
37CDK81.20624966
38IRAK31.20085646
39MAP2K31.19777370
40STK241.19245857
41INSRR1.12277545
42STK101.11731466
43ERBB21.08040242
44PAK21.06096239
45LMTK21.05307225
46MAP2K61.03940282
47NME21.03746367
48TGFBR21.03084527
49FER1.00721500
50BRSK20.96221557
51BMX0.92937767
52MAP3K80.92808396
53NEK20.89688440
54MAP3K30.88888857
55EPHB10.86434478
56DYRK1B0.85302313
57FGFR30.85180350
58ACVR1B0.84951656
59PRKAA20.82623558
60FGFR10.82277430
61WEE10.81757614
62WNK10.80336887
63NTRK10.80298386
64MET0.80128738
65PRPF4B0.79510803
66SRPK10.78431625
67MOS0.78109202
68MAPK110.77734505
69SIK30.76662045
70FGFR20.75890128
71NEK90.75443649
72DMPK0.75215903
73JAK10.74689752
74BRD40.74394405
75LRRK20.74045750
76STK30.73562998
77TSSK60.72098720
78AURKB0.71906400
79JAK30.71708499
80RPS6KB20.70981912
81KDR0.70113151
82MST1R0.67945616
83SGK30.66798756
84STK380.66182373
85CHUK0.62712864
86TIE10.62411252
87MAP2K20.62386084
88TGFBR10.62253823
89TAF10.60453722
90MAP3K50.59713140
91PRKG20.59596085
92AKT20.59562899
93TTK0.59560924
94CDK90.59124797
95STK390.58909084
96TYK20.58159427
97EIF2AK30.57726166
98EPHB20.57249817
99PDGFRB0.55830536
100KSR10.55324322
101PRKAA10.54712522
102PIK3CG0.53657623
103CDC42BPA0.53385220
104PIK3CA0.52672359
105CDK40.51907666
106CDC70.51587036
107CSF1R0.51510726
108GRK60.50687026
109PLK10.50373216
110TESK10.50174453
111MELK0.49963083
112JAK20.49793564
113CHEK10.49494013
114PTK2B0.49383922
115ERBB40.44548764
116ROCK20.44211426
117YES10.44210650
118SCYL20.43537914
119PRKD20.43355732
120LATS20.42012441
121RPS6KA40.41785359
122RET0.41781021
123MAP3K90.39825495
124NUAK10.39534427
125CSK0.39055477
126GSK3A0.37196255
127TRPM70.34456035
128BRSK10.33622904
129ROCK10.33341450
130NEK60.32883531
131CHEK20.32393189
132MYLK0.32321562
133NLK0.32275176
134PRKD10.32268148
135MAPK10.31935656
136BRAF0.30863239
137PDK30.30009181
138PDK40.30009181
139PAK30.29600190
140CDK70.28838787
141MAPK70.28616918

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.49128977
2Nitrogen metabolism_Homo sapiens_hsa009103.41179986
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29282547
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17120898
5Arginine biosynthesis_Homo sapiens_hsa002202.93152060
6Fatty acid degradation_Homo sapiens_hsa000712.51237931
7Complement and coagulation cascades_Homo sapiens_hsa046102.30118826
8Tryptophan metabolism_Homo sapiens_hsa003802.26823356
9Caffeine metabolism_Homo sapiens_hsa002322.13294220
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05524291
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05328435
12Fat digestion and absorption_Homo sapiens_hsa049752.00621901
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98087141
14PPAR signaling pathway_Homo sapiens_hsa033201.96662712
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93684346
16Thyroid cancer_Homo sapiens_hsa052161.90705661
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88597824
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84328630
19TGF-beta signaling pathway_Homo sapiens_hsa043501.79705809
20Lysine degradation_Homo sapiens_hsa003101.79447460
21Bile secretion_Homo sapiens_hsa049761.76840327
22Selenocompound metabolism_Homo sapiens_hsa004501.66104701
23Fatty acid metabolism_Homo sapiens_hsa012121.64450276
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57375088
25Starch and sucrose metabolism_Homo sapiens_hsa005001.54103009
26Tight junction_Homo sapiens_hsa045301.53278306
27Histidine metabolism_Homo sapiens_hsa003401.50672265
28Chemical carcinogenesis_Homo sapiens_hsa052041.50496300
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49391631
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49258186
31Cell cycle_Homo sapiens_hsa041101.48547389
32Prostate cancer_Homo sapiens_hsa052151.47795533
33Retinol metabolism_Homo sapiens_hsa008301.46437994
34Propanoate metabolism_Homo sapiens_hsa006401.45557751
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.44653651
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44146542
37ABC transporters_Homo sapiens_hsa020101.44104215
38Biosynthesis of amino acids_Homo sapiens_hsa012301.43424233
39beta-Alanine metabolism_Homo sapiens_hsa004101.43272598
40Phenylalanine metabolism_Homo sapiens_hsa003601.38282299
41Peroxisome_Homo sapiens_hsa041461.34525660
42Butanoate metabolism_Homo sapiens_hsa006501.31886501
43Staphylococcus aureus infection_Homo sapiens_hsa051501.28766038
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24734981
45p53 signaling pathway_Homo sapiens_hsa041151.20883467
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20211488
47Pancreatic cancer_Homo sapiens_hsa052121.19572578
48Carbon metabolism_Homo sapiens_hsa012001.18889472
49Hedgehog signaling pathway_Homo sapiens_hsa043401.18717197
50Non-homologous end-joining_Homo sapiens_hsa034501.17912828
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17134576
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.17039671
53Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15230807
54Endometrial cancer_Homo sapiens_hsa052131.14484253
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12699716
56Vitamin digestion and absorption_Homo sapiens_hsa049771.11110512
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11091117
58DNA replication_Homo sapiens_hsa030301.09916140
59Pyruvate metabolism_Homo sapiens_hsa006201.08282425
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07909421
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06592594
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.05023323
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.04633759
64Tyrosine metabolism_Homo sapiens_hsa003501.02265259
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.99958909
66Wnt signaling pathway_Homo sapiens_hsa043100.96745452
67One carbon pool by folate_Homo sapiens_hsa006700.96538988
68Pathways in cancer_Homo sapiens_hsa052000.94267783
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93549502
70Glycerolipid metabolism_Homo sapiens_hsa005610.89940605
71Sulfur metabolism_Homo sapiens_hsa009200.89492110
72Glioma_Homo sapiens_hsa052140.89144815
73Colorectal cancer_Homo sapiens_hsa052100.89138039
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88021741
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86755456
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85490307
77Insulin resistance_Homo sapiens_hsa049310.84629954
78ErbB signaling pathway_Homo sapiens_hsa040120.84240061
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82186860
80Arginine and proline metabolism_Homo sapiens_hsa003300.81344685
81Nucleotide excision repair_Homo sapiens_hsa034200.80818620
82Dilated cardiomyopathy_Homo sapiens_hsa054140.80015791
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79162449
84Folate biosynthesis_Homo sapiens_hsa007900.78958235
85Apoptosis_Homo sapiens_hsa042100.77131505
86mRNA surveillance pathway_Homo sapiens_hsa030150.76268156
87N-Glycan biosynthesis_Homo sapiens_hsa005100.75950480
88Renal cell carcinoma_Homo sapiens_hsa052110.72493286
89Shigellosis_Homo sapiens_hsa051310.71520104
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70619733
91Melanoma_Homo sapiens_hsa052180.69817148
92Protein digestion and absorption_Homo sapiens_hsa049740.68534679
93Sphingolipid metabolism_Homo sapiens_hsa006000.67306731
94HTLV-I infection_Homo sapiens_hsa051660.66855657
95Galactose metabolism_Homo sapiens_hsa000520.66144590
96Melanogenesis_Homo sapiens_hsa049160.66050407
97Fructose and mannose metabolism_Homo sapiens_hsa000510.65692637
98Mismatch repair_Homo sapiens_hsa034300.65150630
99RNA transport_Homo sapiens_hsa030130.65118271
100Adherens junction_Homo sapiens_hsa045200.65051435
101ECM-receptor interaction_Homo sapiens_hsa045120.64872625
102Non-small cell lung cancer_Homo sapiens_hsa052230.64157856
103Hepatitis C_Homo sapiens_hsa051600.64071719
104Viral carcinogenesis_Homo sapiens_hsa052030.60366341
105Circadian rhythm_Homo sapiens_hsa047100.58149890
106Hepatitis B_Homo sapiens_hsa051610.56759657
107Fatty acid biosynthesis_Homo sapiens_hsa000610.56631386
108Gap junction_Homo sapiens_hsa045400.56050082
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54522117
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.53935098
111Renin-angiotensin system_Homo sapiens_hsa046140.52569155
112FoxO signaling pathway_Homo sapiens_hsa040680.51414782
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.50976658
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49976657
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49772852
116Rap1 signaling pathway_Homo sapiens_hsa040150.49002883
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.48818016
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48263256
119Small cell lung cancer_Homo sapiens_hsa052220.47304554
120Pentose phosphate pathway_Homo sapiens_hsa000300.46857413
121Bladder cancer_Homo sapiens_hsa052190.46555282
122Focal adhesion_Homo sapiens_hsa045100.46264803
123Choline metabolism in cancer_Homo sapiens_hsa052310.45563735
124AMPK signaling pathway_Homo sapiens_hsa041520.44178659
125Axon guidance_Homo sapiens_hsa043600.43998797
126Base excision repair_Homo sapiens_hsa034100.43867306
127Acute myeloid leukemia_Homo sapiens_hsa052210.41236997
128Endocytosis_Homo sapiens_hsa041440.40904133
129Proteoglycans in cancer_Homo sapiens_hsa052050.40790867
130Amoebiasis_Homo sapiens_hsa051460.40680790
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40130387
132TNF signaling pathway_Homo sapiens_hsa046680.39312018
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37674465
134Glucagon signaling pathway_Homo sapiens_hsa049220.37208823
135Notch signaling pathway_Homo sapiens_hsa043300.36529485
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35761818
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34639070
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33277146
139Glutathione metabolism_Homo sapiens_hsa004800.32880639
140Steroid biosynthesis_Homo sapiens_hsa001000.32707946
141Basal cell carcinoma_Homo sapiens_hsa052170.31505515
142Sulfur relay system_Homo sapiens_hsa041220.30335503
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28395455
144mTOR signaling pathway_Homo sapiens_hsa041500.27728700
145Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26827925
146Prion diseases_Homo sapiens_hsa050200.26697812
147MicroRNAs in cancer_Homo sapiens_hsa052060.24711118
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23340703
149Insulin signaling pathway_Homo sapiens_hsa049100.23116038
150Mineral absorption_Homo sapiens_hsa049780.22283028
151Fatty acid elongation_Homo sapiens_hsa000620.21288824
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.20600900
153Chronic myeloid leukemia_Homo sapiens_hsa052200.20535754
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19162969
155Type II diabetes mellitus_Homo sapiens_hsa049300.18191684
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17918589
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.16127416
158Hippo signaling pathway_Homo sapiens_hsa043900.15210714

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