DNMT3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.65017081
2regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.68972654
3negative regulation of DNA-dependent DNA replication (GO:2000104)4.34779029
4negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.28750870
5regulation of posttranscriptional gene silencing (GO:0060147)4.23273622
6regulation of gene silencing by miRNA (GO:0060964)4.23273622
7regulation of gene silencing by RNA (GO:0060966)4.23273622
8behavioral response to nicotine (GO:0035095)4.14214814
9cardiac left ventricle morphogenesis (GO:0003214)4.08328788
10neuron recognition (GO:0008038)4.03644269
11DNA double-strand break processing (GO:0000729)3.97552819
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.91147970
13suckling behavior (GO:0001967)3.89942257
14glutamate secretion (GO:0014047)3.88218492
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.77126865
16kidney morphogenesis (GO:0060993)3.74709992
17regulation of respiratory system process (GO:0044065)3.69104441
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.66468508
19regulation of nuclear cell cycle DNA replication (GO:0033262)3.58884542
20retinal ganglion cell axon guidance (GO:0031290)3.52069910
21synaptic transmission, glutamatergic (GO:0035249)3.45984357
22regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40636569
23regulation of mitotic spindle checkpoint (GO:1903504)3.40636569
24chromatin remodeling at centromere (GO:0031055)3.36651875
25somite development (GO:0061053)3.24608627
26forebrain neuron development (GO:0021884)3.23659491
27regulation of telomere maintenance (GO:0032204)3.22135283
28regulation of mesoderm development (GO:2000380)3.18334183
29nitric oxide mediated signal transduction (GO:0007263)3.17041879
30negative regulation of telomere maintenance (GO:0032205)3.16903167
31DNA deamination (GO:0045006)3.15813855
32replication fork processing (GO:0031297)3.15635699
33regulation of helicase activity (GO:0051095)3.13383978
34water-soluble vitamin biosynthetic process (GO:0042364)3.12748507
35regulation of feeding behavior (GO:0060259)3.11725538
36lung-associated mesenchyme development (GO:0060484)3.08555774
37axon ensheathment in central nervous system (GO:0032291)3.07853531
38central nervous system myelination (GO:0022010)3.07853531
39synaptic vesicle maturation (GO:0016188)3.07395796
40glutamate receptor signaling pathway (GO:0007215)3.05571159
41neuron cell-cell adhesion (GO:0007158)3.04802176
42daunorubicin metabolic process (GO:0044597)3.04442507
43polyketide metabolic process (GO:0030638)3.04442507
44doxorubicin metabolic process (GO:0044598)3.04442507
45regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03017719
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02715477
47somatic hypermutation of immunoglobulin genes (GO:0016446)3.02715477
48histone exchange (GO:0043486)3.01874708
49histone H3-K4 trimethylation (GO:0080182)3.01673192
50regulation of respiratory gaseous exchange (GO:0043576)3.00992556
51regulation of telomere maintenance via telomerase (GO:0032210)2.99576779
52CENP-A containing nucleosome assembly (GO:0034080)2.99371666
53negative regulation of telomerase activity (GO:0051974)2.97988825
54dendritic spine morphogenesis (GO:0060997)2.96830843
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96667146
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91942943
57cell proliferation in forebrain (GO:0021846)2.90244698
58neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89878830
59neuron-neuron synaptic transmission (GO:0007270)2.89539372
60presynaptic membrane organization (GO:0097090)2.89310198
61DNA replication checkpoint (GO:0000076)2.87622373
62head development (GO:0060322)2.84726088
63fucose catabolic process (GO:0019317)2.82126034
64L-fucose metabolic process (GO:0042354)2.82126034
65L-fucose catabolic process (GO:0042355)2.82126034
66negative regulation of DNA recombination (GO:0045910)2.80861191
67single strand break repair (GO:0000012)2.79641864
68sulfation (GO:0051923)2.79319073
69apical protein localization (GO:0045176)2.79307586
70limb bud formation (GO:0060174)2.78744532
71calcium ion import (GO:0070509)2.78105207
72cerebellar Purkinje cell differentiation (GO:0021702)2.77533786
73regulation of collateral sprouting (GO:0048670)2.77310293
74pyrimidine nucleobase catabolic process (GO:0006208)2.76984209
75stress granule assembly (GO:0034063)2.76473855
76regulation of non-canonical Wnt signaling pathway (GO:2000050)2.75699695
77spinal cord development (GO:0021510)2.73402492
78axonal fasciculation (GO:0007413)2.73027514
79negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72200524
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71617322
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.71012467
82eye photoreceptor cell differentiation (GO:0001754)2.70766709
83photoreceptor cell differentiation (GO:0046530)2.70766709
84membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70193401
85positive regulation of catecholamine secretion (GO:0033605)2.69879684
86regulation of meiosis I (GO:0060631)2.68324098
87positive regulation of RNA splicing (GO:0033120)2.67587872
88central nervous system projection neuron axonogenesis (GO:0021952)2.66891682
89dorsal/ventral axis specification (GO:0009950)2.66661013
90somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66426556
91isotype switching (GO:0045190)2.66426556
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66426556
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66241162
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.65602109
95NADH dehydrogenase complex assembly (GO:0010257)2.65602109
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65602109
97behavioral defense response (GO:0002209)2.64836777
98behavioral fear response (GO:0001662)2.64836777
99synapsis (GO:0007129)2.64111278
100telomere maintenance via telomerase (GO:0007004)2.63872580
101otic vesicle formation (GO:0030916)2.63671397
102protein polyglutamylation (GO:0018095)2.62762148
103DNA replication-dependent nucleosome assembly (GO:0006335)2.60968313
104DNA replication-dependent nucleosome organization (GO:0034723)2.60968313
105adult walking behavior (GO:0007628)2.60683200
106recombinational repair (GO:0000725)2.60527644
107double-strand break repair via homologous recombination (GO:0000724)2.59298616
108chemosensory behavior (GO:0007635)2.59225721
109dendrite morphogenesis (GO:0048813)2.57603799
110ncRNA catabolic process (GO:0034661)2.56099138
111transmission of nerve impulse (GO:0019226)2.55795355
112regulation of histone H3-K9 methylation (GO:0051570)2.55653798
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.55457399
114peptidyl-lysine trimethylation (GO:0018023)2.50944142
115axon extension (GO:0048675)2.50698433
116cerebral cortex radially oriented cell migration (GO:0021799)2.50490942
117somatic recombination of immunoglobulin gene segments (GO:0016447)2.49659119
118layer formation in cerebral cortex (GO:0021819)2.49630670
119somatic diversification of immunoglobulins (GO:0016445)2.49011552
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48269955
121negative regulation of translation, ncRNA-mediated (GO:0040033)2.48258819
122regulation of translation, ncRNA-mediated (GO:0045974)2.48258819
123negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48258819
124central nervous system neuron development (GO:0021954)2.47032392
125negative regulation of neurotransmitter secretion (GO:0046929)2.47029159
126regulation of synapse assembly (GO:0051963)2.46970263
127positive regulation of oligodendrocyte differentiation (GO:0048714)2.46916350
128protein complex biogenesis (GO:0070271)2.46389258
129DNA demethylation (GO:0080111)2.45805922
130female gonad development (GO:0008585)2.45672166
131membrane depolarization during action potential (GO:0086010)2.45570501
132DNA replication-independent nucleosome organization (GO:0034724)2.45435473
133DNA replication-independent nucleosome assembly (GO:0006336)2.45435473
134regulation of gene silencing (GO:0060968)2.44691283
135histone H3-K9 methylation (GO:0051567)2.44172687
136DNA strand renaturation (GO:0000733)2.43585154
137regulation of synapse organization (GO:0050807)2.43183678
138anterior/posterior axis specification, embryo (GO:0008595)2.42474508
139pituitary gland development (GO:0021983)2.41764908
140mitochondrial respiratory chain complex assembly (GO:0033108)2.40700652
141lysine metabolic process (GO:0006553)2.40649434
142lysine catabolic process (GO:0006554)2.40649434
143fear response (GO:0042596)2.40629918
144dendritic spine organization (GO:0097061)2.40268449
145asymmetric protein localization (GO:0008105)2.39209665
146somatic diversification of immune receptors (GO:0002200)2.37745643
147somatic cell DNA recombination (GO:0016444)2.37172804
148somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.37172804
149establishment of mitochondrion localization (GO:0051654)2.36918350
150myelination (GO:0042552)2.36227606
151regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.36125295
152regulation of growth hormone secretion (GO:0060123)2.35894976
153cell migration in hindbrain (GO:0021535)2.35499211
154regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35290503
155mRNA splice site selection (GO:0006376)2.35180752
156histone lysine methylation (GO:0034968)2.33687936
157regulation of synaptic vesicle exocytosis (GO:2000300)2.32909021
158locomotory exploration behavior (GO:0035641)2.32497923
159ensheathment of neurons (GO:0007272)2.31848995
160axon ensheathment (GO:0008366)2.31848995
161regulation of postsynaptic membrane potential (GO:0060078)2.31549852
162negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.31304140
163lateral sprouting from an epithelium (GO:0060601)2.30962851
164neuronal ion channel clustering (GO:0045161)2.30301481
165establishment of protein localization to mitochondrial membrane (GO:0090151)2.30230058
166somite rostral/caudal axis specification (GO:0032525)2.29898091
167regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.28576219
168positive regulation of CREB transcription factor activity (GO:0032793)2.28406752
169neural tube formation (GO:0001841)2.27986167
170protein neddylation (GO:0045116)2.27831530
171DNA damage response, detection of DNA damage (GO:0042769)2.26925525
172atrial cardiac muscle cell action potential (GO:0086014)2.26706237
173intra-S DNA damage checkpoint (GO:0031573)2.26635057
174protein localization to synapse (GO:0035418)2.25994972
175dicarboxylic acid biosynthetic process (GO:0043650)2.25887548
176negative regulation of behavior (GO:0048521)2.25731091
177positive regulation of mRNA processing (GO:0050685)2.25416262
178photoreceptor cell maintenance (GO:0045494)2.23713958
179response to lipoprotein particle (GO:0055094)2.23109758
180pre-miRNA processing (GO:0031054)2.22833427
181regulation of DNA endoreduplication (GO:0032875)2.22068285
182spinal cord motor neuron differentiation (GO:0021522)2.21912774
183cell communication by electrical coupling (GO:0010644)2.21671309
184positive regulation of dendritic spine development (GO:0060999)2.21303883
185epithelial cell fate commitment (GO:0072148)2.20531262
186cerebellar granule cell differentiation (GO:0021707)2.18892439
187negative regulation of neurotransmitter transport (GO:0051589)2.18190238
188positive regulation of dendritic spine morphogenesis (GO:0061003)2.18175565
189presynaptic membrane assembly (GO:0097105)2.17371837
190negative regulation of axon guidance (GO:1902668)2.17045988
191innervation (GO:0060384)2.16870022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.05670348
2EZH2_22144423_ChIP-Seq_EOC_Human3.95182159
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.67130870
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.45709002
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09314609
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54041945
7* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46111178
8POU5F1_16153702_ChIP-ChIP_HESCs_Human2.41632856
9DROSHA_22980978_ChIP-Seq_HELA_Human2.27433849
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15177979
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.13371540
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11901283
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.07050491
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05271649
15TAF15_26573619_Chip-Seq_HEK293_Human1.97768592
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95319521
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95114816
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95114816
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.95063754
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.94914738
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88970510
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87645099
23E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86529563
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85865497
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85479295
26* RARB_27405468_Chip-Seq_BRAIN_Mouse1.85185511
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84689581
28FUS_26573619_Chip-Seq_HEK293_Human1.82779996
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.82046517
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80806969
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76401206
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.72566037
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.72494446
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.71543739
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70478912
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67822497
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66840730
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.65225472
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65089052
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64791752
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60319314
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59179950
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57542108
44ZNF274_21170338_ChIP-Seq_K562_Hela1.54195208
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.53662843
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51944748
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51220298
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51175246
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50856688
50MYC_18940864_ChIP-ChIP_HL60_Human1.50450416
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.50348481
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.50088196
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49843384
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.49200689
55* REST_21632747_ChIP-Seq_MESCs_Mouse1.48655464
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48024526
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.47814551
58* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46739152
59SMAD4_21799915_ChIP-Seq_A2780_Human1.46626199
60* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46360526
61STAT3_23295773_ChIP-Seq_U87_Human1.45626834
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.43963861
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43939366
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.43013446
65SALL1_21062744_ChIP-ChIP_HESCs_Human1.41519519
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41495123
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.41024214
68* ISL1_27105846_Chip-Seq_CPCs_Mouse1.40891032
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39995224
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.39199962
71LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38501399
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38303827
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38014335
74IGF1R_20145208_ChIP-Seq_DFB_Human1.37035254
75VDR_22108803_ChIP-Seq_LS180_Human1.36070686
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35467185
77TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34301974
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.34239005
79* REST_18959480_ChIP-ChIP_MESCs_Mouse1.32992058
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31751563
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30631626
82TCF4_23295773_ChIP-Seq_U87_Human1.30429440
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29813857
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29381584
85E2F7_22180533_ChIP-Seq_HELA_Human1.28978360
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28809007
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28538556
88* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28285194
89* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28256293
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28020539
91EWS_26573619_Chip-Seq_HEK293_Human1.26998023
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26411116
93BCAT_22108803_ChIP-Seq_LS180_Human1.26118848
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24182384
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22651843
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.21433496
97P300_19829295_ChIP-Seq_ESCs_Human1.21295871
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.20499373
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18973437
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18815344
101ER_23166858_ChIP-Seq_MCF-7_Human1.18442568
102* AR_19668381_ChIP-Seq_PC3_Human1.18182343
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16463327
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16140653
105IRF1_19129219_ChIP-ChIP_H3396_Human1.16098246
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15401390
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14560655
108CBP_20019798_ChIP-Seq_JUKART_Human1.14560655
109AR_25329375_ChIP-Seq_VCAP_Human1.14397462
110RNF2_27304074_Chip-Seq_NSC_Mouse1.14280327
111AHR_22903824_ChIP-Seq_MCF-7_Human1.13676369
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.13676094
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.12840205
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.11954907
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11599016
116* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11302239
117RUNX2_22187159_ChIP-Seq_PCA_Human1.09651742
118SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09359349
119SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09320878
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08911549
121* RING1B_27294783_Chip-Seq_ESCs_Mouse1.08533205
122SOX2_19829295_ChIP-Seq_ESCs_Human1.08278256
123NANOG_19829295_ChIP-Seq_ESCs_Human1.08278256
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08201183
125TCF4_22108803_ChIP-Seq_LS180_Human1.07763101
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07733554
127AR_21572438_ChIP-Seq_LNCaP_Human1.07474751
128MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07006987
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06939541
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06726700
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06726700
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05232365
133ELK1_19687146_ChIP-ChIP_HELA_Human1.05213023
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.05144849
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04608465
136* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03803696
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03636223
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03276580
139POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.03234617
140KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02973019
141NFE2_27457419_Chip-Seq_LIVER_Mouse1.01716071
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01267486
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.99317322
144CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98762828
145TP53_22573176_ChIP-Seq_HFKS_Human0.97476454
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97391497
147GATA1_26923725_Chip-Seq_HPCs_Mouse0.97250711
148* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95799886
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.95788063
150* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91866538
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91696881
152* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90731265
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.90184133
154* FLI1_21867929_ChIP-Seq_TH2_Mouse0.90120103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.96682475
2MP0000516_abnormal_urinary_system3.31733603
3MP0005367_renal/urinary_system_phenotyp3.31733603
4MP0005670_abnormal_white_adipose2.82057111
5MP0003880_abnormal_central_pattern2.56963714
6MP0002102_abnormal_ear_morphology2.38772134
7MP0003122_maternal_imprinting2.34983754
8MP0002735_abnormal_chemical_nociception2.12476052
9MP0008058_abnormal_DNA_repair2.07793556
10MP0006072_abnormal_retinal_apoptosis2.05288420
11MP0003567_abnormal_fetal_cardiomyocyte2.04328358
12MP0002736_abnormal_nociception_after2.03514836
13MP0000569_abnormal_digit_pigmentation2.03504930
14MP0001188_hyperpigmentation2.01854561
15MP0003123_paternal_imprinting2.01679942
16MP0008057_abnormal_DNA_replication1.99141435
17MP0003121_genomic_imprinting1.95595825
18MP0003693_abnormal_embryo_hatching1.90526067
19MP0003635_abnormal_synaptic_transmissio1.89916618
20MP0000778_abnormal_nervous_system1.86766664
21MP0001293_anophthalmia1.81163891
22MP0004885_abnormal_endolymph1.81085697
23* MP0000955_abnormal_spinal_cord1.73009484
24MP0002272_abnormal_nervous_system1.70685047
25MP0004270_analgesia1.67897657
26MP0003718_maternal_effect1.66582584
27MP0005409_darkened_coat_color1.65171805
28MP0002254_reproductive_system_inflammat1.64796540
29MP0003787_abnormal_imprinting1.64705088
30MP0010094_abnormal_chromosome_stability1.64381418
31MP0005253_abnormal_eye_physiology1.63541203
32MP0005551_abnormal_eye_electrophysiolog1.63042621
33MP0001299_abnormal_eye_distance/1.62201680
34MP0003283_abnormal_digestive_organ1.60983126
35MP0002064_seizures1.60530320
36MP0000534_abnormal_ureter_morphology1.59360699
37MP0001968_abnormal_touch/_nociception1.58194959
38MP0006292_abnormal_olfactory_placode1.57524542
39MP0003195_calcinosis1.51425456
40MP0003646_muscle_fatigue1.51370997
41MP0002638_abnormal_pupillary_reflex1.51365334
42MP0001486_abnormal_startle_reflex1.48226557
43MP0003136_yellow_coat_color1.48104357
44MP0009780_abnormal_chondrocyte_physiolo1.48057233
45MP0001501_abnormal_sleep_pattern1.45589260
46MP0002184_abnormal_innervation1.44490843
47MP0000631_abnormal_neuroendocrine_gland1.43779344
48MP0003941_abnormal_skin_development1.42200914
49MP0005423_abnormal_somatic_nervous1.41783961
50* MP0002063_abnormal_learning/memory/cond1.40977577
51MP0002067_abnormal_sensory_capabilities1.38043962
52MP0009703_decreased_birth_body1.37781085
53MP0000003_abnormal_adipose_tissue1.37082136
54MP0006276_abnormal_autonomic_nervous1.37037836
55* MP0002882_abnormal_neuron_morphology1.36768894
56MP0003634_abnormal_glial_cell1.36631017
57MP0004145_abnormal_muscle_electrophysio1.36377700
58* MP0002572_abnormal_emotion/affect_behav1.35750335
59MP0009745_abnormal_behavioral_response1.31846784
60MP0002234_abnormal_pharynx_morphology1.30225900
61MP0003861_abnormal_nervous_system1.29611723
62MP0008872_abnormal_physiological_respon1.29478181
63MP0003878_abnormal_ear_physiology1.28854101
64MP0005377_hearing/vestibular/ear_phenot1.28854101
65MP0001440_abnormal_grooming_behavior1.27462132
66MP0000013_abnormal_adipose_tissue1.25123603
67MP0000049_abnormal_middle_ear1.24677662
68MP0002557_abnormal_social/conspecific_i1.22471987
69MP0002160_abnormal_reproductive_system1.20597557
70MP0001286_abnormal_eye_development1.19440444
71MP0005195_abnormal_posterior_eye1.18571684
72MP0004742_abnormal_vestibular_system1.17386553
73MP0009046_muscle_twitch1.15801392
74MP0008789_abnormal_olfactory_epithelium1.14435196
75MP0005646_abnormal_pituitary_gland1.13551206
76MP0002152_abnormal_brain_morphology1.12913190
77* MP0002752_abnormal_somatic_nervous1.12390803
78MP0001984_abnormal_olfaction1.11735849
79MP0000428_abnormal_craniofacial_morphol1.11398215
80MP0003385_abnormal_body_wall1.10353490
81MP0001485_abnormal_pinna_reflex1.09974946
82MP0003937_abnormal_limbs/digits/tail_de1.09735110
83MP0003011_delayed_dark_adaptation1.09370021
84MP0002233_abnormal_nose_morphology1.09242833
85MP0000462_abnormal_digestive_system1.08586701
86MP0003119_abnormal_digestive_system1.07411049
87MP0005391_vision/eye_phenotype1.07222996
88MP0004811_abnormal_neuron_physiology1.06469730
89MP0008995_early_reproductive_senescence1.06062977
90MP0005645_abnormal_hypothalamus_physiol1.05970038
91MP0005386_behavior/neurological_phenoty1.04963094
92MP0004924_abnormal_behavior1.04963094
93MP0005499_abnormal_olfactory_system1.02699035
94MP0005394_taste/olfaction_phenotype1.02699035
95MP0003935_abnormal_craniofacial_develop1.02416811
96MP0000747_muscle_weakness1.01941879
97MP0000566_synostosis1.01833384
98MP0002734_abnormal_mechanical_nocicepti1.01595717
99MP0003938_abnormal_ear_development1.00911597
100MP0002116_abnormal_craniofacial_bone0.99722620
101MP0002229_neurodegeneration0.99173525
102MP0000920_abnormal_myelination0.97520940
103MP0004142_abnormal_muscle_tone0.96700358
104MP0002697_abnormal_eye_size0.96290933
105MP0002837_dystrophic_cardiac_calcinosis0.95591935
106MP0001963_abnormal_hearing_physiology0.95445477
107MP0010030_abnormal_orbit_morphology0.94853727
108MP0005248_abnormal_Harderian_gland0.94619087
109MP0004085_abnormal_heartbeat0.94158583
110MP0001529_abnormal_vocalization0.94041019
111MP0002210_abnormal_sex_determination0.93151058
112MP0005389_reproductive_system_phenotype0.92209924
113MP0002138_abnormal_hepatobiliary_system0.91331056
114* MP0008877_abnormal_DNA_methylation0.90894646
115MP0004957_abnormal_blastocyst_morpholog0.90767241
116MP0002938_white_spotting0.90008777
117MP0004233_abnormal_muscle_weight0.89310705
118MP0001177_atelectasis0.88784736
119MP0003942_abnormal_urinary_system0.88552604
120MP0002751_abnormal_autonomic_nervous0.86688067
121MP0000653_abnormal_sex_gland0.86661961
122MP0001145_abnormal_male_reproductive0.85911529
123MP0003890_abnormal_embryonic-extraembry0.84917441
124MP0002081_perinatal_lethality0.84567440
125MP0000026_abnormal_inner_ear0.84446685
126MP0001929_abnormal_gametogenesis0.84396188
127* MP0002066_abnormal_motor_capabilities/c0.83517564
128MP0000537_abnormal_urethra_morphology0.83496214
129MP0009672_abnormal_birth_weight0.83425825
130MP0003950_abnormal_plasma_membrane0.82362999
131MP0001970_abnormal_pain_threshold0.81941001
132MP0004133_heterotaxia0.81476986
133MP0003755_abnormal_palate_morphology0.80898049
134MP0002653_abnormal_ependyma_morphology0.80188009
135MP0004510_myositis0.78571672
136MP0003111_abnormal_nucleus_morphology0.78549071
137MP0005084_abnormal_gallbladder_morpholo0.78507904
138MP0001986_abnormal_taste_sensitivity0.78339300
139MP0001119_abnormal_female_reproductive0.77775846
140MP0005220_abnormal_exocrine_pancreas0.77271407
141MP0003698_abnormal_male_reproductive0.75774374
142MP0003077_abnormal_cell_cycle0.73010732

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)4.47307516
2Muscle hypertrophy of the lower extremities (HP:0008968)4.13797784
3Abnormality of the labia minora (HP:0012880)4.12210664
4Hypoventilation (HP:0002791)3.96559178
5Cerebellar dysplasia (HP:0007033)3.63800984
6Shoulder girdle muscle weakness (HP:0003547)3.55686380
7Colon cancer (HP:0003003)3.49503518
8Type II lissencephaly (HP:0007260)3.42761168
9Pelvic girdle muscle weakness (HP:0003749)3.31841963
10Pancreatic cysts (HP:0001737)3.17480948
11Abnormality of the musculature of the pelvis (HP:0001469)3.06674011
12Abnormality of the hip-girdle musculature (HP:0001445)3.06674011
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.91702476
14Renal hypoplasia (HP:0000089)2.84801539
15Pancreatic fibrosis (HP:0100732)2.83843496
16Abolished electroretinogram (ERG) (HP:0000550)2.73310672
17Stenosis of the external auditory canal (HP:0000402)2.72764691
18Nephronophthisis (HP:0000090)2.72258720
19Follicular hyperkeratosis (HP:0007502)2.70603745
20Intestinal atresia (HP:0011100)2.68752445
21True hermaphroditism (HP:0010459)2.67606858
22Ectopic kidney (HP:0000086)2.66122368
23Neoplasm of the adrenal cortex (HP:0100641)2.62282167
24Limb-girdle muscle atrophy (HP:0003797)2.61531842
25Abnormality of midbrain morphology (HP:0002418)2.54587105
26Molar tooth sign on MRI (HP:0002419)2.54587105
27Congenital stationary night blindness (HP:0007642)2.53036201
28Severe visual impairment (HP:0001141)2.50169311
29Aqueductal stenosis (HP:0002410)2.45715337
30Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.44153271
31Abnormality of the pons (HP:0007361)2.43900987
32Meckel diverticulum (HP:0002245)2.42543026
33Frequent falls (HP:0002359)2.40622645
34Epileptic encephalopathy (HP:0200134)2.40280290
35Abnormality of the ileum (HP:0001549)2.38225596
36Oligodactyly (hands) (HP:0001180)2.37416717
37Hypoplasia of the pons (HP:0012110)2.32074932
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.28477286
39Bilateral microphthalmos (HP:0007633)2.26478089
40Abnormality of the renal medulla (HP:0100957)2.25650834
41Methylmalonic acidemia (HP:0002912)2.25454753
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24547144
43Increased corneal curvature (HP:0100692)2.20805569
44Keratoconus (HP:0000563)2.20805569
45Degeneration of the lateral corticospinal tracts (HP:0002314)2.19444596
46Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19444596
47Abnormality of the calf musculature (HP:0001430)2.18850182
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.18535797
49Supranuclear gaze palsy (HP:0000605)2.17963736
50Birth length less than 3rd percentile (HP:0003561)2.17851639
51Optic nerve hypoplasia (HP:0000609)2.17824192
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.16993619
53Patellar aplasia (HP:0006443)2.16788823
54Hyperglycinemia (HP:0002154)2.16031309
55Abnormality of the parathyroid morphology (HP:0011766)2.15690102
56Proximal amyotrophy (HP:0007126)2.14560180
57Chronic hepatic failure (HP:0100626)2.14491150
58Chromsome breakage (HP:0040012)2.12414391
59Abnormality of chromosome stability (HP:0003220)2.10380241
60Anteriorly placed anus (HP:0001545)2.10099835
61Abnormality of the corticospinal tract (HP:0002492)2.09362051
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.08477097
63Flat cornea (HP:0007720)2.08207910
64Obsessive-compulsive behavior (HP:0000722)2.07613323
65Aplasia/Hypoplasia of the patella (HP:0006498)2.06276957
66Asplenia (HP:0001746)2.05818227
67Febrile seizures (HP:0002373)2.05442590
68Renal duplication (HP:0000075)2.04824435
69Small hand (HP:0200055)2.04512051
70Supernumerary spleens (HP:0009799)2.02554349
71Congenital malformation of the right heart (HP:0011723)2.02504924
72Double outlet right ventricle (HP:0001719)2.02504924
73Abnormal lung lobation (HP:0002101)2.00552716
74Macroglossia (HP:0000158)2.00417020
75Hepatoblastoma (HP:0002884)1.99697951
76Progressive cerebellar ataxia (HP:0002073)1.98900013
77Short hallux (HP:0010109)1.98256943
78Midline defect of the nose (HP:0004122)1.98234852
79Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94880013
80Short 4th metacarpal (HP:0010044)1.94880013
81Abnormality of the renal collecting system (HP:0004742)1.94835421
82Oligodactyly (HP:0012165)1.94096122
83Anencephaly (HP:0002323)1.93852306
84Excessive salivation (HP:0003781)1.93464927
85Drooling (HP:0002307)1.93464927
86Cystic liver disease (HP:0006706)1.93340226
87Achilles tendon contracture (HP:0001771)1.92996970
88Aplasia/Hypoplasia of the hallux (HP:0008362)1.91706305
89Abnormal hair whorl (HP:0010721)1.91211405
90Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91013079
91Hypoplasia of the brainstem (HP:0002365)1.91013079
92Absent thumb (HP:0009777)1.90609090
93Absent radius (HP:0003974)1.89943590
94Labial hypoplasia (HP:0000066)1.89871207
95Dandy-Walker malformation (HP:0001305)1.88546838
96Esophageal atresia (HP:0002032)1.87411731
97Gastroesophageal reflux (HP:0002020)1.86489524
98Abnormality of glycine metabolism (HP:0010895)1.85269339
99Abnormality of serine family amino acid metabolism (HP:0010894)1.85269339
100Carpal bone hypoplasia (HP:0001498)1.85259340
101Absent forearm bone (HP:0003953)1.85238930
102Aplasia involving forearm bones (HP:0009822)1.85238930
103Bile duct proliferation (HP:0001408)1.84297655
104Abnormal biliary tract physiology (HP:0012439)1.84297655
105Hypoplastic female external genitalia (HP:0012815)1.84092906
106Poor eye contact (HP:0000817)1.83737096
107Triphalangeal thumb (HP:0001199)1.83119223
108Genital tract atresia (HP:0001827)1.82060862
109Widely spaced teeth (HP:0000687)1.81869474
110Chin dimple (HP:0010751)1.80852435
111Horseshoe kidney (HP:0000085)1.80805074
112Cutaneous finger syndactyly (HP:0010554)1.80639734
113Nonprogressive disorder (HP:0003680)1.80339670
114Nephroblastoma (Wilms tumor) (HP:0002667)1.80174072
115Protruding tongue (HP:0010808)1.80168299
116Vaginal atresia (HP:0000148)1.80034623
117Astrocytoma (HP:0009592)1.79510730
118Abnormality of the astrocytes (HP:0100707)1.79510730
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78775962
120Methylmalonic aciduria (HP:0012120)1.78713968
121Hyperglycinuria (HP:0003108)1.78485905
122Overriding aorta (HP:0002623)1.78351099
123Vesicoureteral reflux (HP:0000076)1.77857110
124Broad distal phalanx of finger (HP:0009836)1.76734715
125Anophthalmia (HP:0000528)1.76317321
126Bony spicule pigmentary retinopathy (HP:0007737)1.75864169
127Macroorchidism (HP:0000053)1.74997741
128Anal stenosis (HP:0002025)1.74494481
129Medial flaring of the eyebrow (HP:0010747)1.74402096
130Limb-girdle muscle weakness (HP:0003325)1.74026098
131Hypoplastic labia majora (HP:0000059)1.72227766
132Visual hallucinations (HP:0002367)1.72107301
133Inability to walk (HP:0002540)1.71553985
134Abnormality of the duodenum (HP:0002246)1.71345429
135Cupped ear (HP:0000378)1.71218228
136Gaze-evoked nystagmus (HP:0000640)1.70911870
137Short 1st metacarpal (HP:0010034)1.69765523
138Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69765523
139Abnormality of the preputium (HP:0100587)1.69389473
140Preaxial hand polydactyly (HP:0001177)1.68449001
141Sclerocornea (HP:0000647)1.68312052
142Morphological abnormality of the middle ear (HP:0008609)1.67944893
143Embryonal renal neoplasm (HP:0011794)1.67309542
144Abnormal rod and cone electroretinograms (HP:0008323)1.66804001
145Gastrointestinal atresia (HP:0002589)1.66412556
146Abnormality of the renal cortex (HP:0011035)1.66363620
147Homocystinuria (HP:0002156)1.66176070
148Abnormality of homocysteine metabolism (HP:0010919)1.66176070
149Neoplasm of the adrenal gland (HP:0100631)1.66059935
150Rhabdomyosarcoma (HP:0002859)1.65972794
151Absent septum pellucidum (HP:0001331)1.65806777
152Broad-based gait (HP:0002136)1.65735394
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65670394
154Mixed hearing impairment (HP:0000410)1.65510791
155Attenuation of retinal blood vessels (HP:0007843)1.65413378
156Abnormality of serum amino acid levels (HP:0003112)1.64848636
157Progressive inability to walk (HP:0002505)1.64620650
158Sloping forehead (HP:0000340)1.64603980
159Volvulus (HP:0002580)1.64574964
160Abnormality of the septum pellucidum (HP:0007375)1.64181969
161Maternal diabetes (HP:0009800)1.63990119
162Pendular nystagmus (HP:0012043)1.63855046
163Absent speech (HP:0001344)1.60707703
164Focal motor seizures (HP:0011153)1.59319573
165Vitreoretinal degeneration (HP:0000655)1.58650716
166Meningocele (HP:0002435)1.57179679
167Intellectual disability, profound (HP:0002187)1.56444462
168Cutaneous syndactyly (HP:0012725)1.56024188
169Poor head control (HP:0002421)1.55900124
170Neurofibrillary tangles (HP:0002185)1.55121303
171Septo-optic dysplasia (HP:0100842)1.54431618
172Bladder diverticulum (HP:0000015)1.53088493
173Focal seizures (HP:0007359)1.51473763
174Abnormality of the shoulder girdle musculature (HP:0001435)1.51444959
175Inappropriate behavior (HP:0000719)1.50828434
176Impaired social interactions (HP:0000735)1.48972999
177Abnormal social behavior (HP:0012433)1.48972999
178Agitation (HP:0000713)1.48919903
179Ependymoma (HP:0002888)1.48885442
180Abnormality of the labia majora (HP:0012881)1.48797064
181Genetic anticipation (HP:0003743)1.47641069
182Central scotoma (HP:0000603)1.47208505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.73883533
2FRK3.31002720
3MARK13.19188779
4NUAK12.73675276
5BMPR1B2.66174445
6ZAK2.64288267
7CAMK1G2.63945549
8EPHA42.31613669
9TAF12.28128600
10TRIM282.22370909
11PNCK2.18708679
12ACVR1B2.12179040
13GRK12.02698096
14CAMK1D2.02121347
15NTRK21.98525788
16NTRK31.84210834
17VRK21.73702661
18INSRR1.73192574
19MKNK11.72714401
20MKNK21.70034782
21PLK31.68436294
22LATS11.68214071
23PASK1.67838508
24TSSK61.67225464
25UHMK11.57646410
26ICK1.53762178
27PLK41.51695571
28MARK21.51464960
29MAP4K21.51241137
30BRD41.51165922
31PRPF4B1.48034736
32PAK61.47050774
33TLK11.45868148
34NLK1.45166186
35VRK11.45040930
36MAP3K41.43706878
37CLK11.39854638
38SIK21.36354920
39PLK21.34390742
40BUB11.33727491
41YES11.29196748
42TIE11.28961328
43ADRBK21.28599994
44TNIK1.25354179
45STK391.25050795
46PKN11.24760716
47MAPK131.24450345
48PRKD31.21557848
49TTK1.20508997
50ALK1.18090788
51CDK121.18073584
52WNK11.15361364
53PINK11.14906419
54PHKG21.14590722
55PHKG11.14590722
56BCR1.12817326
57DYRK1A1.10964298
58MAPK151.08336850
59PRKCH1.07591464
60PDGFRB1.07032887
61NTRK11.05874164
62SGK11.01353944
63PLK11.01084865
64HIPK20.98754481
65PRKCG0.98561894
66BRSK20.98392499
67CSNK1G20.97823787
68TGFBR10.97692817
69CSNK1A1L0.95019991
70SGK4940.94381513
71SGK2230.94381513
72DYRK20.94285824
73PDGFRA0.94219647
74DMPK0.93821801
75PTK60.93402315
76DYRK30.89944895
77NME10.88136327
78CDK50.87930598
79FGFR20.87257404
80ERBB30.86507013
81ATR0.85401930
82CAMKK20.83611983
83GSK3B0.82353700
84CDC70.79725000
85MINK10.78018989
86DAPK20.77463183
87CDK190.74874489
88MST40.73702834
89CDK90.73406761
90MAPK140.71311501
91ABL10.71305692
92CDC42BPA0.70807739
93MAPK100.70205402
94CAMK10.70202918
95MAPK90.69681153
96WNK40.68295284
97CASK0.68166787
98PAK30.68105044
99CSNK1G30.67805536
100OBSCN0.66967198
101TXK0.66714591
102PRKDC0.66511150
103FGFR10.65182409
104MAPK80.64720332
105PRKG10.64698348
106MAP3K70.64058023
107NEK60.63475236
108CSNK1E0.63218806
109ATM0.63191854
110OXSR10.63040616
111CAMKK10.62717864
112CHEK10.61857304
113CDK20.61673585
114CDK10.61644467
115CSNK1D0.60616728
116MTOR0.60517212
117PRKCB0.60417923
118SRPK10.60298164
119STK38L0.60290367
120CAMK2D0.59487813
121PRKD20.59437489
122CSNK1G10.59335465
123PRKCE0.59020799
124WNK30.57363407
125FYN0.56944010
126SGK20.56639648
127CAMK2A0.56629127
128STK110.56393089
129ERBB20.55686381
130MAP2K70.55447907
131WEE10.54639183
132RPS6KA30.54510441
133CSNK1A10.52377172
134CHEK20.52367907
135KSR10.50896602
136NEK20.50300200
137CAMK40.49628837
138EIF2AK20.47924477
139TEC0.47787666
140TYRO30.47093494
141FLT30.47048646
142CDK30.46729877
143PIK3CA0.46638932
144TAOK30.44601732
145MAP3K100.41170085
146AKT30.40181438
147STK30.38470571
148SGK30.36976381
149PRKCZ0.33339254
150PRKCQ0.33003398
151MAPKAPK50.31987105

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.84805146
2RNA polymerase_Homo sapiens_hsa030202.57913912
3Non-homologous end-joining_Homo sapiens_hsa034502.45081785
4Glutamatergic synapse_Homo sapiens_hsa047242.38290414
5Mismatch repair_Homo sapiens_hsa034302.37588319
6Fanconi anemia pathway_Homo sapiens_hsa034602.36416227
7Protein export_Homo sapiens_hsa030602.33677516
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33391695
9Basal transcription factors_Homo sapiens_hsa030222.26480054
10RNA degradation_Homo sapiens_hsa030182.24920170
11Cocaine addiction_Homo sapiens_hsa050302.17351596
12GABAergic synapse_Homo sapiens_hsa047272.16605713
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14339771
14Phototransduction_Homo sapiens_hsa047442.14147964
15Axon guidance_Homo sapiens_hsa043602.13449906
16Circadian entrainment_Homo sapiens_hsa047132.10542200
17Vibrio cholerae infection_Homo sapiens_hsa051102.03715105
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00316633
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.97421090
20Long-term potentiation_Homo sapiens_hsa047201.94276062
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93116249
22Selenocompound metabolism_Homo sapiens_hsa004501.92872962
23Synaptic vesicle cycle_Homo sapiens_hsa047211.87595224
24Morphine addiction_Homo sapiens_hsa050321.78299337
25Propanoate metabolism_Homo sapiens_hsa006401.72322113
26DNA replication_Homo sapiens_hsa030301.68655355
27Amphetamine addiction_Homo sapiens_hsa050311.67911393
28Long-term depression_Homo sapiens_hsa047301.66216313
29Insulin secretion_Homo sapiens_hsa049111.64785316
30Type II diabetes mellitus_Homo sapiens_hsa049301.64420542
31RNA transport_Homo sapiens_hsa030131.63054964
32Dopaminergic synapse_Homo sapiens_hsa047281.58495973
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.57464346
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57353636
35Linoleic acid metabolism_Homo sapiens_hsa005911.55805637
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50307579
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49108064
38One carbon pool by folate_Homo sapiens_hsa006701.39871267
39Steroid biosynthesis_Homo sapiens_hsa001001.37733842
40Cholinergic synapse_Homo sapiens_hsa047251.36697284
41Olfactory transduction_Homo sapiens_hsa047401.33156889
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30767738
43Proteasome_Homo sapiens_hsa030501.30686717
44Nitrogen metabolism_Homo sapiens_hsa009101.28918328
45Taste transduction_Homo sapiens_hsa047421.26454985
46Vitamin digestion and absorption_Homo sapiens_hsa049771.26229573
47Lysine degradation_Homo sapiens_hsa003101.25226466
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22198728
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19590921
50Butanoate metabolism_Homo sapiens_hsa006501.18730996
51Base excision repair_Homo sapiens_hsa034101.18145614
52Spliceosome_Homo sapiens_hsa030401.17705132
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16419100
54Serotonergic synapse_Homo sapiens_hsa047261.16225068
55Basal cell carcinoma_Homo sapiens_hsa052171.10103838
56Dilated cardiomyopathy_Homo sapiens_hsa054141.09568936
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08920019
58cAMP signaling pathway_Homo sapiens_hsa040241.07692355
59Nucleotide excision repair_Homo sapiens_hsa034201.07690578
60Oxidative phosphorylation_Homo sapiens_hsa001901.06793585
61Homologous recombination_Homo sapiens_hsa034401.06149607
62Parkinsons disease_Homo sapiens_hsa050121.05209268
63Hedgehog signaling pathway_Homo sapiens_hsa043401.05184640
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04677569
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04481768
66Renin secretion_Homo sapiens_hsa049241.03310387
67ErbB signaling pathway_Homo sapiens_hsa040121.02261375
68Tryptophan metabolism_Homo sapiens_hsa003800.99956790
69Oocyte meiosis_Homo sapiens_hsa041140.97391397
70Wnt signaling pathway_Homo sapiens_hsa043100.97310307
71Oxytocin signaling pathway_Homo sapiens_hsa049210.96820953
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96764850
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96041259
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95987153
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95437879
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94259693
77Salivary secretion_Homo sapiens_hsa049700.93948966
78Ribosome_Homo sapiens_hsa030100.93200276
79Purine metabolism_Homo sapiens_hsa002300.92651165
80Retinol metabolism_Homo sapiens_hsa008300.91489351
81Renal cell carcinoma_Homo sapiens_hsa052110.91470797
82Caffeine metabolism_Homo sapiens_hsa002320.91373319
83Melanogenesis_Homo sapiens_hsa049160.89511663
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89209123
85* Cysteine and methionine metabolism_Homo sapiens_hsa002700.88529085
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87843343
87Collecting duct acid secretion_Homo sapiens_hsa049660.86523913
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85024277
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84578261
90Huntingtons disease_Homo sapiens_hsa050160.83679761
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83547024
92Calcium signaling pathway_Homo sapiens_hsa040200.83266235
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83166578
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82890323
95Notch signaling pathway_Homo sapiens_hsa043300.82035825
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80069836
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77790483
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76474488
99Cardiac muscle contraction_Homo sapiens_hsa042600.76443571
100Ether lipid metabolism_Homo sapiens_hsa005650.76035205
101Endometrial cancer_Homo sapiens_hsa052130.75903575
102* MicroRNAs in cancer_Homo sapiens_hsa052060.75587286
103MAPK signaling pathway_Homo sapiens_hsa040100.75492144
104mRNA surveillance pathway_Homo sapiens_hsa030150.74058023
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73997507
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73888353
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.73221652
108Alcoholism_Homo sapiens_hsa050340.72465875
109Peroxisome_Homo sapiens_hsa041460.72101791
110Sphingolipid metabolism_Homo sapiens_hsa006000.71807006
111Hippo signaling pathway_Homo sapiens_hsa043900.71699685
112mTOR signaling pathway_Homo sapiens_hsa041500.71123876
113Gastric acid secretion_Homo sapiens_hsa049710.70134590
114Gap junction_Homo sapiens_hsa045400.69963648
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69824336
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.69431937
117Estrogen signaling pathway_Homo sapiens_hsa049150.69149512
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67626063
119Ras signaling pathway_Homo sapiens_hsa040140.66729952
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.66265404
121GnRH signaling pathway_Homo sapiens_hsa049120.65132767
122Chronic myeloid leukemia_Homo sapiens_hsa052200.65032437
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64979250
124Type I diabetes mellitus_Homo sapiens_hsa049400.62941449
125Pyrimidine metabolism_Homo sapiens_hsa002400.61761120
126Primary immunodeficiency_Homo sapiens_hsa053400.60526961
127Colorectal cancer_Homo sapiens_hsa052100.60404558
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59812606
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59568502
130Vitamin B6 metabolism_Homo sapiens_hsa007500.59196694
131Tight junction_Homo sapiens_hsa045300.59059666
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.58955025
133Glycerolipid metabolism_Homo sapiens_hsa005610.58574028
134Ovarian steroidogenesis_Homo sapiens_hsa049130.56646911
135Pancreatic secretion_Homo sapiens_hsa049720.55482505
136Inositol phosphate metabolism_Homo sapiens_hsa005620.55266380
137Glioma_Homo sapiens_hsa052140.54036640
138Cell cycle_Homo sapiens_hsa041100.53930356
139Adherens junction_Homo sapiens_hsa045200.52859053
140Dorso-ventral axis formation_Homo sapiens_hsa043200.52368553
141Prostate cancer_Homo sapiens_hsa052150.51862304
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51031448
143Rap1 signaling pathway_Homo sapiens_hsa040150.50964909
144Alzheimers disease_Homo sapiens_hsa050100.50796801
145Choline metabolism in cancer_Homo sapiens_hsa052310.50749858
146TGF-beta signaling pathway_Homo sapiens_hsa043500.50228953
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50166130
148T cell receptor signaling pathway_Homo sapiens_hsa046600.48107502
149Fat digestion and absorption_Homo sapiens_hsa049750.47496435
150Steroid hormone biosynthesis_Homo sapiens_hsa001400.47266046
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46842453
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45389572
153Phagosome_Homo sapiens_hsa041450.45334530
154p53 signaling pathway_Homo sapiens_hsa041150.44793150
155Chemical carcinogenesis_Homo sapiens_hsa052040.44045189
156Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43097436
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43023012
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.41112335
159beta-Alanine metabolism_Homo sapiens_hsa004100.40748740
160* Metabolic pathways_Homo sapiens_hsa011000.39342773
161Arachidonic acid metabolism_Homo sapiens_hsa005900.38042929

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