DNMT3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of oxidative phosphorylation (GO:0002082)6.86283265
2regulation of cellular respiration (GO:0043457)6.67738762
3regulation of posttranscriptional gene silencing (GO:0060147)6.43672671
4regulation of gene silencing by miRNA (GO:0060964)6.43672671
5regulation of gene silencing by RNA (GO:0060966)6.43672671
6pyrimidine-containing compound transmembrane transport (GO:0072531)5.95169325
7cranial suture morphogenesis (GO:0060363)5.61954828
8blastocyst development (GO:0001824)5.52419874
9chaperone-mediated protein transport (GO:0072321)5.33888966
10nuclear pore organization (GO:0006999)5.08051397
11ribosomal small subunit assembly (GO:0000028)5.01239163
12regulation of DNA methylation (GO:0044030)4.99409476
13mitochondrial RNA metabolic process (GO:0000959)4.84175338
14DNA replication-dependent nucleosome assembly (GO:0006335)4.80358310
15DNA replication-dependent nucleosome organization (GO:0034723)4.80358310
16folic acid-containing compound biosynthetic process (GO:0009396)4.79512193
17DNA replication initiation (GO:0006270)4.76217181
18transcription from mitochondrial promoter (GO:0006390)4.74613328
19nuclear pore complex assembly (GO:0051292)4.70496174
20regulation of helicase activity (GO:0051095)4.66861577
21nucleobase biosynthetic process (GO:0046112)4.63744018
22mitotic metaphase plate congression (GO:0007080)4.58720751
23nucleoside transmembrane transport (GO:1901642)4.58681859
24protein localization to kinetochore (GO:0034501)4.50293035
25nodal signaling pathway (GO:0038092)4.41064594
26IMP biosynthetic process (GO:0006188)4.40050727
27nucleoside transport (GO:0015858)4.35511527
28ribosome assembly (GO:0042255)4.35124892
29pseudouridine synthesis (GO:0001522)4.32600039
30purine nucleobase biosynthetic process (GO:0009113)4.30201007
31regulation of mitochondrial translation (GO:0070129)4.23888495
32mitotic nuclear envelope disassembly (GO:0007077)4.22033605
33protein-cofactor linkage (GO:0018065)4.15089630
34somatic hypermutation of immunoglobulin genes (GO:0016446)4.05993765
35somatic diversification of immune receptors via somatic mutation (GO:0002566)4.05993765
36DNA unwinding involved in DNA replication (GO:0006268)4.04714016
37regulation of histone H3-K9 methylation (GO:0051570)4.03610990
38negative regulation of epidermal cell differentiation (GO:0045605)4.02938525
39negative regulation of histone methylation (GO:0031061)4.02064841
40rRNA modification (GO:0000154)4.01634093
41formation of translation preinitiation complex (GO:0001731)4.00790808
42protein K6-linked ubiquitination (GO:0085020)3.99605322
43protein targeting to mitochondrion (GO:0006626)3.95641351
44proteasome assembly (GO:0043248)3.93936145
45membrane disassembly (GO:0030397)3.93786874
46nuclear envelope disassembly (GO:0051081)3.93786874
47mitotic sister chromatid segregation (GO:0000070)3.91589948
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.90594164
49DNA strand elongation involved in DNA replication (GO:0006271)3.87232202
50IMP metabolic process (GO:0046040)3.87121099
51determination of adult lifespan (GO:0008340)3.86751566
52positive regulation of SMAD protein import into nucleus (GO:0060391)3.85829860
53metaphase plate congression (GO:0051310)3.85767094
54ribosome biogenesis (GO:0042254)3.84974527
55keratinocyte development (GO:0003334)3.82145338
56notochord development (GO:0030903)3.81415811
57ncRNA 3-end processing (GO:0043628)3.81160364
58regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79509144
59apoptotic process involved in morphogenesis (GO:0060561)3.76383601
60maturation of SSU-rRNA (GO:0030490)3.74216219
61pentose metabolic process (GO:0019321)3.73159992
62regulation of gene silencing (GO:0060968)3.70833670
63primitive streak formation (GO:0090009)3.68728502
64pre-miRNA processing (GO:0031054)3.66862196
65DNA strand elongation (GO:0022616)3.65725700
66protein localization to chromosome, centromeric region (GO:0071459)3.63861946
67DNA replication checkpoint (GO:0000076)3.62922179
68paraxial mesoderm development (GO:0048339)3.61775383
69establishment of protein localization to mitochondrion (GO:0072655)3.57419409
70pore complex assembly (GO:0046931)3.57318641
71positive regulation of chromosome segregation (GO:0051984)3.56276472
72regulation of spindle organization (GO:0090224)3.50403063
73regulation of translational termination (GO:0006449)3.48556057
74anterior/posterior axis specification, embryo (GO:0008595)3.46197031
75ATP hydrolysis coupled proton transport (GO:0015991)3.45838994
76energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.45838994
77histone H2A monoubiquitination (GO:0035518)3.45272248
78rRNA methylation (GO:0031167)3.42911133
79DNA geometric change (GO:0032392)3.42720912
80DNA duplex unwinding (GO:0032508)3.42651665
81regulation of translational fidelity (GO:0006450)3.40655259
82embryonic process involved in female pregnancy (GO:0060136)3.40530050
83sister chromatid segregation (GO:0000819)3.39604546
84chromatin remodeling at centromere (GO:0031055)3.39548176
85regulation of mitotic spindle organization (GO:0060236)3.38823818
86histone H4-K12 acetylation (GO:0043983)3.38795277
87establishment of chromosome localization (GO:0051303)3.38558625
88regulation of telomere maintenance via telomerase (GO:0032210)3.37301414
89mesenchymal cell proliferation (GO:0010463)3.36145718
90heterochromatin organization (GO:0070828)3.36060981
91ribonucleoprotein complex biogenesis (GO:0022613)3.32063440
92protein localization to mitochondrion (GO:0070585)3.31964436
93craniofacial suture morphogenesis (GO:0097094)3.28254770
94telomere maintenance via semi-conservative replication (GO:0032201)3.26896899
95cell fate commitment involved in formation of primary germ layer (GO:0060795)3.25254649
96folic acid metabolic process (GO:0046655)3.23577460
97regulation of centrosome cycle (GO:0046605)3.21782327
98negative regulation of gene silencing (GO:0060969)3.18879490
99mitotic chromosome condensation (GO:0007076)3.18761115
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18252620
101vitamin transmembrane transport (GO:0035461)3.15543741
102activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.15460302
103histone arginine methylation (GO:0034969)3.15096349
104chaperone-mediated protein complex assembly (GO:0051131)3.14352379
105negative regulation of epidermis development (GO:0045683)3.13970362
106CENP-A containing nucleosome assembly (GO:0034080)3.13533384
107regulation of SMAD protein import into nucleus (GO:0060390)3.13385092
108myeloid cell homeostasis (GO:0002262)3.10281356
109response to dietary excess (GO:0002021)3.09696918
110DNA replication-independent nucleosome organization (GO:0034724)3.08045374
111DNA replication-independent nucleosome assembly (GO:0006336)3.08045374
112ribosomal large subunit biogenesis (GO:0042273)3.07628930
113regulation of chromosome segregation (GO:0051983)3.07619236
114spindle assembly involved in mitosis (GO:0090307)3.06642993
115rRNA processing (GO:0006364)3.05017214
116establishment of apical/basal cell polarity (GO:0035089)3.04974261
117regulation of nuclear cell cycle DNA replication (GO:0033262)3.03733436
118basic amino acid transport (GO:0015802)3.03586387
119regulation of hippo signaling (GO:0035330)3.00374648
120negative regulation of chromosome segregation (GO:0051985)3.00101673
121attachment of spindle microtubules to kinetochore (GO:0008608)2.99040350
122negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99015986
123serine family amino acid biosynthetic process (GO:0009070)2.98605396
124transferrin transport (GO:0033572)2.98119884
125lung-associated mesenchyme development (GO:0060484)2.97914140
126pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.97673615
127UMP metabolic process (GO:0046049)2.97673615
128pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.97673615
129UMP biosynthetic process (GO:0006222)2.97673615
130rRNA metabolic process (GO:0016072)2.96480040
131nuclear envelope organization (GO:0006998)2.95831074
132protein complex localization (GO:0031503)2.95809698
133telomere maintenance via telomere lengthening (GO:0010833)2.94771205
134translation (GO:0006412)2.94548976
135spindle checkpoint (GO:0031577)2.93971878
136histone exchange (GO:0043486)2.93249942
137negative regulation of androgen receptor signaling pathway (GO:0060766)2.92507147
138chromatin assembly (GO:0031497)2.92386061
139regulation of centriole replication (GO:0046599)2.92255068
140male meiosis I (GO:0007141)2.92124350
141tRNA aminoacylation for protein translation (GO:0006418)2.91861865
142telomere maintenance via recombination (GO:0000722)2.90924304
143aerobic respiration (GO:0009060)2.90677728
144mismatch repair (GO:0006298)2.88597391
145positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.88418854
146positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.88418854
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.88418854
148mitotic spindle checkpoint (GO:0071174)2.88325393
149negative regulation of mitochondrion organization (GO:0010823)2.88226394
150maturation of 5.8S rRNA (GO:0000460)2.87846610
151negative regulation of mitotic sister chromatid separation (GO:2000816)2.87513021
152negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87513021
153negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87513021
154negative regulation of sister chromatid segregation (GO:0033046)2.87513021
155peptidyl-arginine omega-N-methylation (GO:0035247)2.87353802
156chromatin assembly or disassembly (GO:0006333)2.85961369
157mitochondrial fusion (GO:0008053)2.85851547
158regulation of double-strand break repair via homologous recombination (GO:0010569)2.85633364
159oxidative phosphorylation (GO:0006119)2.85033023
160L-alpha-amino acid transmembrane transport (GO:1902475)2.83361315
161amino acid activation (GO:0043038)2.82684068
162tRNA aminoacylation (GO:0043039)2.82684068
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.81804978
164termination of RNA polymerase III transcription (GO:0006386)2.81804978
165vagina development (GO:0060068)2.81199897
166cellular response to oxygen radical (GO:0071450)2.78150615
167removal of superoxide radicals (GO:0019430)2.78150615
168cellular response to superoxide (GO:0071451)2.78150615
169respiratory chain complex IV assembly (GO:0008535)2.78016906
1704-hydroxyproline metabolic process (GO:0019471)2.76374883
171peptidyl-histidine modification (GO:0018202)2.76261420
172negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.75200154
173apoptotic process involved in development (GO:1902742)2.72895945
174ferric iron transport (GO:0015682)2.71270509
175trivalent inorganic cation transport (GO:0072512)2.71270509
176translational initiation (GO:0006413)2.69320569
177DNA deamination (GO:0045006)2.69241564
178cellular component biogenesis (GO:0044085)2.68601817
179intracellular protein transmembrane import (GO:0044743)2.67935158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.21338815
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.01718847
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.98824730
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.36430689
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.26214516
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.24710026
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.24710026
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.24710026
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21156616
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.19161845
11* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.07060259
12NANOG_18555785_ChIP-Seq_MESCs_Mouse2.77567768
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76115773
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73864456
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66501157
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.58093821
17* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47852869
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45543702
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41690517
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33189727
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25896420
22TCF3_18692474_ChIP-Seq_MEFs_Mouse2.25532929
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.22955459
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20893881
25STAT3_1855785_ChIP-Seq_MESCs_Mouse2.20489071
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19684030
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19345923
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19328903
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10402293
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.09591682
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.09498686
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.07494956
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03194561
34SOX2_18555785_ChIP-Seq_MESCs_Mouse2.00248659
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98904974
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97123502
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95923592
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92335805
39SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90400645
40XRN2_22483619_ChIP-Seq_HELA_Human1.88490878
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88066620
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87524373
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86235901
44* SALL1_21062744_ChIP-ChIP_HESCs_Human1.86036766
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84621765
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81439834
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.80495901
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.79260928
49AR_21909140_ChIP-Seq_LNCAP_Human1.78077546
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77132673
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74463280
52NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.71372988
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.70540382
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.65891525
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.59575888
56* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58814207
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.53585284
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53372015
59VDR_23849224_ChIP-Seq_CD4+_Human1.47932581
60* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.45925198
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44811529
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42060988
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42041894
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.41015369
65NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.40719308
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40406385
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39161944
68* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.37590540
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37120611
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.36698371
71* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36389524
72* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35934446
73TTF2_22483619_ChIP-Seq_HELA_Human1.35704228
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.33432503
75* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.32915886
76DCP1A_22483619_ChIP-Seq_HELA_Human1.32793885
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30891119
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.30787751
79IRF1_19129219_ChIP-ChIP_H3396_Human1.30126551
80FOXP3_21729870_ChIP-Seq_TREG_Human1.30065612
81GABP_19822575_ChIP-Seq_HepG2_Human1.28169963
82* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27431313
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27307183
84* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.24151272
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24064400
86KDM5A_27292631_Chip-Seq_BREAST_Human1.22654610
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22436395
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15929088
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.15863152
90KAP1_27257070_Chip-Seq_ESCs_Mouse1.15427378
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14959039
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14698860
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10707337
94MYC_22102868_ChIP-Seq_BL_Human1.10373005
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10010860
96CIITA_25753668_ChIP-Seq_RAJI_Human1.09546964
97ZNF263_19887448_ChIP-Seq_K562_Human1.09373577
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09370549
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06524569
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06195258
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04954633
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04787121
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04664683
104TET1_21451524_ChIP-Seq_MESCs_Mouse1.04281265
105TFEB_21752829_ChIP-Seq_HELA_Human1.02676333
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02581054
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02088195
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01063704
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98963774
110ELK1_19687146_ChIP-ChIP_HELA_Human0.98482377
111* BCOR_27268052_Chip-Seq_Bcells_Human0.97570241
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96293295
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94391019
114LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94118822
115* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93830748
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92984548
117NANOG_16518401_ChIP-PET_MESCs_Mouse0.92350732
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91679729
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90351513
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89664142
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88573178
122* CTCF_20526341_ChIP-Seq_ESCs_Human0.87850709
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.87806008
124PHF8_20622854_ChIP-Seq_HELA_Human0.87548922
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86496373
126* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85529096
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84721396
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81893581
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81807937
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.79427305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08364753
2MP0004957_abnormal_blastocyst_morpholog4.63870996
3MP0003111_abnormal_nucleus_morphology4.56420591
4MP0010094_abnormal_chromosome_stability4.33909641
5MP0008057_abnormal_DNA_replication3.88422470
6MP0003077_abnormal_cell_cycle3.80781852
7MP0003806_abnormal_nucleotide_metabolis3.61178965
8MP0005670_abnormal_white_adipose3.08000587
9MP0008058_abnormal_DNA_repair3.02162775
10MP0010352_gastrointestinal_tract_polyps2.85452428
11MP0008260_abnormal_autophagy2.83579689
12MP0001730_embryonic_growth_arrest2.76428842
13MP0003878_abnormal_ear_physiology2.64867449
14MP0005377_hearing/vestibular/ear_phenot2.64867449
15MP0006035_abnormal_mitochondrial_morpho2.64415930
16MP0002653_abnormal_ependyma_morphology2.61799754
17MP0003123_paternal_imprinting2.51283230
18MP0008932_abnormal_embryonic_tissue2.50040697
19MP0000350_abnormal_cell_proliferation2.48813172
20MP0008004_abnormal_stomach_pH2.45045093
21MP0002254_reproductive_system_inflammat2.44889705
22MP0004133_heterotaxia2.42285589
23MP0003718_maternal_effect2.38241458
24MP0008872_abnormal_physiological_respon2.31776074
25MP0010307_abnormal_tumor_latency2.23711102
26MP0000647_abnormal_sebaceous_gland2.18291747
27MP0005451_abnormal_body_composition2.17627529
28MP0008007_abnormal_cellular_replicative2.14766250
29MP0002084_abnormal_developmental_patter2.13368879
30MP0001672_abnormal_embryogenesis/_devel2.13060025
31MP0005380_embryogenesis_phenotype2.13060025
32MP0008877_abnormal_DNA_methylation2.12906032
33MP0003941_abnormal_skin_development2.12225677
34MP0001346_abnormal_lacrimal_gland2.06413363
35* MP0002085_abnormal_embryonic_tissue2.05940669
36MP0001697_abnormal_embryo_size1.99099532
37MP0003136_yellow_coat_color1.83568030
38* MP0002086_abnormal_extraembryonic_tissu1.82552049
39MP0003984_embryonic_growth_retardation1.80643041
40MP0004197_abnormal_fetal_growth/weight/1.80415628
41MP0002088_abnormal_embryonic_growth/wei1.77649603
42MP0005076_abnormal_cell_differentiation1.77502599
43MP0003786_premature_aging1.74944419
44* MP0002080_prenatal_lethality1.73948766
45MP0003119_abnormal_digestive_system1.73034265
46MP0006036_abnormal_mitochondrial_physio1.61739481
47MP0003890_abnormal_embryonic-extraembry1.58978287
48MP0000470_abnormal_stomach_morphology1.51094636
49MP0002098_abnormal_vibrissa_morphology1.48444618
50MP0005257_abnormal_intraocular_pressure1.46890578
51MP0003566_abnormal_cell_adhesion1.45315043
52MP0005636_abnormal_mineral_homeostasis1.44411803
53MP0003705_abnormal_hypodermis_morpholog1.44212469
54MP0001293_anophthalmia1.40669513
55MP0009333_abnormal_splenocyte_physiolog1.40331784
56MP0005058_abnormal_lysosome_morphology1.38949727
57MP0001849_ear_inflammation1.37562054
58MP0003121_genomic_imprinting1.37054896
59MP0000383_abnormal_hair_follicle1.33931216
60MP0010234_abnormal_vibrissa_follicle1.33696668
61MP0003283_abnormal_digestive_organ1.29317597
62MP0006292_abnormal_olfactory_placode1.28460680
63* MP0002210_abnormal_sex_determination1.28437940
64MP0002876_abnormal_thyroid_physiology1.27058321
65MP0003567_abnormal_fetal_cardiomyocyte1.26019546
66MP0000313_abnormal_cell_death1.25053836
67* MP0001145_abnormal_male_reproductive1.19433710
68MP0000566_synostosis1.18876795
69MP0004782_abnormal_surfactant_physiolog1.12454134
70MP0000490_abnormal_crypts_of1.12070840
71MP0005266_abnormal_metabolism1.11645880
72MP0002019_abnormal_tumor_incidence1.11322974
73MP0004019_abnormal_vitamin_homeostasis1.10848379
74MP0003183_abnormal_peptide_metabolism1.10813136
75MP0001986_abnormal_taste_sensitivity1.10529482
76MP0002909_abnormal_adrenal_gland1.08337241
77MP0010030_abnormal_orbit_morphology1.06600852
78MP0004264_abnormal_extraembryonic_tissu1.06274629
79* MP0001929_abnormal_gametogenesis1.03485107
80* MP0000653_abnormal_sex_gland0.98924324
81MP0001968_abnormal_touch/_nociception0.98730443
82MP0003315_abnormal_perineum_morphology0.97293764
83MP0000537_abnormal_urethra_morphology0.96596589
84MP0000462_abnormal_digestive_system0.95517877
85MP0001764_abnormal_homeostasis0.95476957
86MP0002111_abnormal_tail_morphology0.95339411
87MP0005023_abnormal_wound_healing0.94475873
88MP0003937_abnormal_limbs/digits/tail_de0.93900837
89MP0002736_abnormal_nociception_after0.93626355
90MP0005623_abnormal_meninges_morphology0.93223344
91MP0005085_abnormal_gallbladder_physiolo0.92311570
92MP0009379_abnormal_foot_pigmentation0.91268343
93MP0000516_abnormal_urinary_system0.90937880
94MP0005367_renal/urinary_system_phenotyp0.90937880
95MP0005666_abnormal_adipose_tissue0.90289396
96MP0005319_abnormal_enzyme/_coenzyme0.89857562
97MP0008995_early_reproductive_senescence0.89469766
98MP0005384_cellular_phenotype0.88576807
99MP0005621_abnormal_cell_physiology0.88565000
100MP0005395_other_phenotype0.87723944
101MP0000358_abnormal_cell_content/0.85563648
102MP0005501_abnormal_skin_physiology0.84282909
103MP0002160_abnormal_reproductive_system0.84136602
104MP0001286_abnormal_eye_development0.83899237
105MP0001915_intracranial_hemorrhage0.83361026
106* MP0003861_abnormal_nervous_system0.82744451
107MP0009703_decreased_birth_body0.81823035
108MP0008874_decreased_physiological_sensi0.80797449
109MP0010678_abnormal_skin_adnexa0.80607444
110MP0003950_abnormal_plasma_membrane0.78790008
111MP0009840_abnormal_foam_cell0.77318481
112MP0003936_abnormal_reproductive_system0.77240962
113MP0003186_abnormal_redox_activity0.77111182
114MP0002697_abnormal_eye_size0.76697423
115MP0001905_abnormal_dopamine_level0.75667267
116MP0009672_abnormal_birth_weight0.75175435
117MP0009053_abnormal_anal_canal0.75137860
118MP0005389_reproductive_system_phenotype0.74506706
119MP0003191_abnormal_cellular_cholesterol0.74499505
120MP0003646_muscle_fatigue0.74168843
121MP0002796_impaired_skin_barrier0.72819692
122MP0001119_abnormal_female_reproductive0.72302326
123MP0004185_abnormal_adipocyte_glucose0.71476032
124MP0003787_abnormal_imprinting0.71110965
125MP0005332_abnormal_amino_acid0.70670294
126MP0000432_abnormal_head_morphology0.68418340
127MP0002249_abnormal_larynx_morphology0.66123289
128MP0002092_abnormal_eye_morphology0.65892764
129MP0002269_muscular_atrophy0.65053024
130MP0008770_decreased_survivor_rate0.64581682
131MP0000858_altered_metastatic_potential0.63998870
132MP0010771_integument_phenotype0.63242195
133* MP0002161_abnormal_fertility/fecundity0.63235295
134MP0002396_abnormal_hematopoietic_system0.62386178
135MP0000750_abnormal_muscle_regeneration0.62321978
136MP0002127_abnormal_cardiovascular_syste0.62185409
137MP0000371_diluted_coat_color0.62102882
138MP0002822_catalepsy0.61907281
139* MP0003698_abnormal_male_reproductive0.61627250
140MP0008875_abnormal_xenobiotic_pharmacok0.61595862
141* MP0003699_abnormal_female_reproductive0.60847265
142MP0000467_abnormal_esophagus_morphology0.60621374
143MP0002877_abnormal_melanocyte_morpholog0.60387934
144MP0002925_abnormal_cardiovascular_devel0.60287713
145MP0005410_abnormal_fertilization0.60047699
146MP0009115_abnormal_fat_cell0.59702049
147MP0000477_abnormal_intestine_morphology0.59174072
148MP0008961_abnormal_basal_metabolism0.58355602
149MP0000627_abnormal_mammary_gland0.58082492
150MP0003329_amyloid_beta_deposits0.57116010
151MP0004233_abnormal_muscle_weight0.56828361
152MP0008873_increased_physiological_sensi0.56666230
153MP0000015_abnormal_ear_pigmentation0.55625427

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.81660056
2Abnormality of the labia minora (HP:0012880)5.07226203
3Birth length less than 3rd percentile (HP:0003561)4.69387331
4Amelogenesis imperfecta (HP:0000705)4.50741489
5Hypomagnesemia (HP:0002917)4.46586529
6Breast hypoplasia (HP:0003187)4.44247138
7Abnormality of magnesium homeostasis (HP:0004921)4.40800138
8Agnosia (HP:0010524)4.14826317
9Medulloblastoma (HP:0002885)4.11429569
10Bilateral sensorineural hearing impairment (HP:0008619)4.03725146
11Astrocytoma (HP:0009592)3.99686561
12Abnormality of the astrocytes (HP:0100707)3.99686561
13Renal tubular acidosis (HP:0001947)3.95793494
14Neoplasm of the oral cavity (HP:0100649)3.89306336
15Absent radius (HP:0003974)3.83618818
16Increased circulating renin level (HP:0000848)3.72850427
17Supernumerary spleens (HP:0009799)3.68833020
18Tetany (HP:0001281)3.65267439
19Chromsome breakage (HP:0040012)3.63169290
20Aplasia involving forearm bones (HP:0009822)3.60363394
21Absent forearm bone (HP:0003953)3.60363394
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59078767
23Rhabdomyosarcoma (HP:0002859)3.56829922
24Bilateral microphthalmos (HP:0007633)3.56135188
25Microvesicular hepatic steatosis (HP:0001414)3.53112232
26Carpal bone hypoplasia (HP:0001498)3.49046513
27Hyperglycinuria (HP:0003108)3.48964634
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.43161576
29Hypoplasia of the fovea (HP:0007750)3.43161576
30Abnormality of alanine metabolism (HP:0010916)3.40226535
31Hyperalaninemia (HP:0003348)3.40226535
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.40226535
33Colon cancer (HP:0003003)3.38769662
34Glioma (HP:0009733)3.32034890
35Impulsivity (HP:0100710)3.26954985
36Selective tooth agenesis (HP:0001592)3.26855322
37Aplasia/hypoplasia of the humerus (HP:0006507)3.23791600
38Paralysis (HP:0003470)3.20513763
39Patellar aplasia (HP:0006443)3.08775190
40Short humerus (HP:0005792)2.99698368
41Abnormality of abdominal situs (HP:0011620)2.98828733
42Abdominal situs inversus (HP:0003363)2.98828733
43Abnormality of cells of the erythroid lineage (HP:0012130)2.93426769
44Neoplasm of striated muscle (HP:0009728)2.91550683
45Abnormality of dental color (HP:0011073)2.90060795
46Abnormal number of erythroid precursors (HP:0012131)2.88937071
47Cerebral hypomyelination (HP:0006808)2.88835150
48Esophageal atresia (HP:0002032)2.86481061
49Shawl scrotum (HP:0000049)2.86214793
50Aplasia/Hypoplasia of the patella (HP:0006498)2.83215075
51Missing ribs (HP:0000921)2.82464775
52Renal tubular dysfunction (HP:0000124)2.80773053
53Biliary tract neoplasm (HP:0100574)2.79935106
54CNS hypomyelination (HP:0003429)2.79243165
55Absent thumb (HP:0009777)2.78920794
56Progressive muscle weakness (HP:0003323)2.78631479
57Limb dystonia (HP:0002451)2.78458015
58Abnormality of the salivary glands (HP:0010286)2.76515951
59Abnormality of chromosome stability (HP:0003220)2.74238982
60Multiple enchondromatosis (HP:0005701)2.73753004
61Abnormal ventriculo-arterial connection (HP:0011563)2.72868633
62Transposition of the great arteries (HP:0001669)2.72868633
63Abnormal connection of the cardiac segments (HP:0011545)2.72868633
64Abnormality of the fovea (HP:0000493)2.72295020
65Meckel diverticulum (HP:0002245)2.70781447
66Oral leukoplakia (HP:0002745)2.70754449
67Increased serum lactate (HP:0002151)2.69815027
68Premature ovarian failure (HP:0008209)2.67632447
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67357708
70Death in infancy (HP:0001522)2.67333748
71Rib fusion (HP:0000902)2.65390962
72Reticulocytopenia (HP:0001896)2.64606205
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.62024654
74Hyperglycinemia (HP:0002154)2.60847340
75Abnormality of the anterior horn cell (HP:0006802)2.58238127
76Degeneration of anterior horn cells (HP:0002398)2.58238127
77Abnormality of the preputium (HP:0100587)2.58108595
78Abnormality of the ileum (HP:0001549)2.55983738
79Basal cell carcinoma (HP:0002671)2.52852288
80Tinnitus (HP:0000360)2.52532802
81Abnormality of serine family amino acid metabolism (HP:0010894)2.50072854
82Abnormality of glycine metabolism (HP:0010895)2.50072854
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48600000
84Increased CSF lactate (HP:0002490)2.48117555
85Rough bone trabeculation (HP:0100670)2.46389389
86Ureteral duplication (HP:0000073)2.46013525
87Hyperglycemia (HP:0003074)2.44381699
88Acute necrotizing encephalopathy (HP:0006965)2.44206772
89Methylmalonic aciduria (HP:0012120)2.44073088
90Patent foramen ovale (HP:0001655)2.42033460
91Stenosis of the external auditory canal (HP:0000402)2.41038196
92Amaurosis fugax (HP:0100576)2.38402130
93Asplenia (HP:0001746)2.36630022
94Dysphonia (HP:0001618)2.35801415
95Neoplasm of the pancreas (HP:0002894)2.31824117
96Lactic acidosis (HP:0003128)2.31219065
97Rectovaginal fistula (HP:0000143)2.31212615
98Rectal fistula (HP:0100590)2.31212615
99Retinal atrophy (HP:0001105)2.30980995
100Aplasia/hypoplasia of the uterus (HP:0008684)2.26739184
101Leukodystrophy (HP:0002415)2.25684967
102Abnormality of pyrimidine metabolism (HP:0004353)2.25650796
103Breast aplasia (HP:0100783)2.25086128
104Myopathic facies (HP:0002058)2.25000048
105Abnormal number of incisors (HP:0011064)2.23170367
106Polydipsia (HP:0001959)2.20664400
107Abnormal drinking behavior (HP:0030082)2.20664400
108Septate vagina (HP:0001153)2.20609913
109Small intestinal stenosis (HP:0012848)2.20285504
110Duodenal stenosis (HP:0100867)2.20285504
111Hypokalemic alkalosis (HP:0001949)2.19602511
112Tracheoesophageal fistula (HP:0002575)2.18873242
113Horseshoe kidney (HP:0000085)2.18793700
114Aplasia/Hypoplasia of the macula (HP:0008059)2.18583268
115Duplicated collecting system (HP:0000081)2.18220565
116Aplasia/Hypoplasia involving the musculature (HP:0001460)2.17669370
117Abnormality of the fetal cardiovascular system (HP:0010948)2.16833124
118Abnormal umbilical cord blood vessels (HP:0011403)2.16833124
119Single umbilical artery (HP:0001195)2.16833124
120Proximal placement of thumb (HP:0009623)2.15346844
121Delayed puberty (HP:0000823)2.14650142
122Aplasia/Hypoplasia of the spleen (HP:0010451)2.13478888
123Vertebral clefting (HP:0008428)2.13456351
124Trismus (HP:0000211)2.12780248
125Sloping forehead (HP:0000340)2.12264370
126Deviation of the thumb (HP:0009603)2.11619998
127Abnormal mitochondria in muscle tissue (HP:0008316)2.11577149
128Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10844851
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10844851
130Abnormality of the lower motor neuron (HP:0002366)2.07955677
131Fused cervical vertebrae (HP:0002949)2.07559511
132Myelodysplasia (HP:0002863)2.07400239
133Supernumerary bones of the axial skeleton (HP:0009144)2.06071778
134Spinal muscular atrophy (HP:0007269)2.05288301
135Gastrointestinal carcinoma (HP:0002672)2.05246300
136Malignant gastrointestinal tract tumors (HP:0006749)2.05246300
137Aplasia/Hypoplasia of the breasts (HP:0010311)2.02136889
138Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01981559
139Conjugated hyperbilirubinemia (HP:0002908)2.01850408
140Cafe-au-lait spot (HP:0000957)2.01162168
141Aplasia/Hypoplasia of the sternum (HP:0006714)2.00432901
142Abnormality of the aortic arch (HP:0012303)2.00290334
143Acute encephalopathy (HP:0006846)2.00208539
144Angiofibromas (HP:0010615)2.00124161
145Adenoma sebaceum (HP:0009720)2.00124161
146Abnormality of the duodenum (HP:0002246)1.99073578
147Gastrointestinal atresia (HP:0002589)1.98905815
148Hypoplasia of the uterus (HP:0000013)1.98750021
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98666588
150Short 1st metacarpal (HP:0010034)1.98666588
151Anal stenosis (HP:0002025)1.97563306
152Mitochondrial inheritance (HP:0001427)1.95873185
153Ovarian neoplasm (HP:0100615)1.94681641
154Poor speech (HP:0002465)1.94608904
155Intestinal fistula (HP:0100819)1.94428622
156Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93496354
157Bone marrow hypocellularity (HP:0005528)1.93367773
158Spastic diplegia (HP:0001264)1.92299130
159Pendular nystagmus (HP:0012043)1.92162551
160Supernumerary ribs (HP:0005815)1.91560412
161Respiratory difficulties (HP:0002880)1.91214425
162Impaired proprioception (HP:0010831)1.90506909
163Vertebral fusion (HP:0002948)1.90484624
164High anterior hairline (HP:0009890)1.89699226
165Short thumb (HP:0009778)1.89144184
166Cerebellar dysplasia (HP:0007033)1.88147818
167Vaginal fistula (HP:0004320)1.86970673
168Increased hepatocellular lipid droplets (HP:0006565)1.86840798
169Ectopic kidney (HP:0000086)1.86667970
170Abnormality of serum amino acid levels (HP:0003112)1.86198238
171Split foot (HP:0001839)1.86178118
172Abnormal biliary tract morphology (HP:0012440)1.86057868
173Fragile nails (HP:0001808)1.85455391
174Secondary amenorrhea (HP:0000869)1.84800497
175Sparse lateral eyebrow (HP:0005338)1.84340443
176Abnormality of the vocal cords (HP:0008777)1.83873325
177Hemivertebrae (HP:0002937)1.83754996
178Aplastic anemia (HP:0001915)1.83037710
179Abnormality of renin-angiotensin system (HP:0000847)1.82990764
180Progressive macrocephaly (HP:0004481)1.81282244
181Osteomalacia (HP:0002749)1.80374729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.18702905
2EPHA24.59403020
3WNK44.47381274
4WEE14.23338535
5STK394.16311452
6BUB13.94996377
7CDK123.43304249
8CDC73.32369651
9PHKG23.28520468
10PHKG13.28520468
11OXSR13.26899435
12TTK3.17844983
13NEK13.08662658
14RPS6KB22.72939777
15TSSK62.66212599
16NEK22.44734879
17PNCK2.27505347
18PLK12.12407618
19AKT32.07414309
20VRK21.95548755
21SRPK11.91308931
22EIF2AK11.87610818
23CDK71.85451734
24PASK1.79570741
25PLK31.67986492
26CHEK21.64411019
27TLK11.60032843
28MAPKAPK31.59066423
29SMG11.55296762
30EEF2K1.53349499
31PINK11.52500553
32ALK1.50370250
33LATS21.49314251
34ATR1.46125284
35AURKB1.44634377
36TESK21.41327779
37MAP3K81.39886554
38AURKA1.38592649
39CHEK11.37542468
40BRSK21.36170664
41CDK41.34442676
42DYRK31.30161714
43BRD41.29796314
44STK38L1.27206497
45MAP3K131.21572564
46PLK41.19635153
47FLT31.17690092
48NME11.16852257
49PRKCI1.13375884
50MET1.13371994
51VRK11.12368305
52ERBB41.12171207
53ACVR1B1.09530517
54EIF2AK31.08491004
55PAK41.05952668
56CDK191.03422243
57SCYL21.02748735
58CDK21.01556681
59ZAK1.00454102
60STK101.00194970
61MAP3K90.97160448
62ATM0.96010871
63PDK30.93881960
64PDK40.93881960
65MKNK20.93089047
66NME20.91334634
67PIM10.91077155
68PRKG20.91043747
69BRAF0.91039377
70PDK20.88173741
71MKNK10.84906398
72STK40.81384830
73PKN20.75908655
74MTOR0.74589677
75MELK0.73647226
76CSNK1D0.72087776
77CSNK2A20.71813426
78CSNK1E0.70354700
79MAP3K140.69999744
80PAK10.69572270
81TGFBR10.69003825
82LATS10.68304716
83CDK10.68244136
84MAP3K60.66157144
85BRSK10.65937343
86KDR0.63616648
87DYRK20.58265807
88CDK60.55396526
89RPS6KA40.53616803
90KSR20.52064281
91ILK0.51954286
92CSNK2A10.51412271
93ICK0.49601382
94AKT20.43978791
95GRK10.43439270
96PRKDC0.43105961
97MST40.42303339
98RPS6KA50.40538441
99STK30.39535209
100BCKDK0.37368528
101MATK0.37068571
102MAPK140.36026180
103DAPK30.35965720
104WNK30.35899906
105TYRO30.33737370
106PKN10.33588265
107PBK0.33270560
108GSK3B0.33082926
109MAPK10.31588346
110NUAK10.30251128
111KSR10.29497754
112ABL20.27165795
113ROCK20.25625068
114MAP2K20.24582780
115AKT10.24180187
116STK160.24068246
117CSNK1A10.23551979
118PRKCD0.23005118
119RAF10.22878885
120MAPK100.22257823
121TESK10.21244539
122DMPK0.21226122
123RPS6KA10.21011867
124MAP2K60.20301183
125FGFR10.19271866
126PRKCG0.18719538
127CAMK2G0.18416972
128BMX0.18301772
129MARK30.17308236
130EIF2AK20.17267822
131CSF1R0.16593571
132RPS6KC10.16541179
133RPS6KL10.16541179
134RPS6KA60.16057309
135CAMK40.14695723
136PRKCZ0.14123214
137PAK20.12516834
138EGFR0.11236567
139PRKAA20.10153259
140RPS6KA20.10127397
141PRKCA0.09104537

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.46409406
2DNA replication_Homo sapiens_hsa030304.37947088
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34597514
4Collecting duct acid secretion_Homo sapiens_hsa049663.60848791
5RNA transport_Homo sapiens_hsa030133.57684122
6One carbon pool by folate_Homo sapiens_hsa006703.53957769
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.35354628
8RNA polymerase_Homo sapiens_hsa030203.29531425
9Spliceosome_Homo sapiens_hsa030403.17184118
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.16409631
11Nucleotide excision repair_Homo sapiens_hsa034202.86921582
12Oxidative phosphorylation_Homo sapiens_hsa001902.82124063
13Homologous recombination_Homo sapiens_hsa034402.75701915
14Cell cycle_Homo sapiens_hsa041102.68157527
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.67242789
16Ribosome_Homo sapiens_hsa030102.49154038
17Proteasome_Homo sapiens_hsa030502.47460899
18Base excision repair_Homo sapiens_hsa034102.45726943
19Fanconi anemia pathway_Homo sapiens_hsa034602.28741343
20Parkinsons disease_Homo sapiens_hsa050122.22261888
21Pyrimidine metabolism_Homo sapiens_hsa002402.14045402
22Basal transcription factors_Homo sapiens_hsa030222.06642825
23Non-homologous end-joining_Homo sapiens_hsa034502.04674823
24RNA degradation_Homo sapiens_hsa030181.95399949
25mRNA surveillance pathway_Homo sapiens_hsa030151.89829740
26Vibrio cholerae infection_Homo sapiens_hsa051101.73797484
27p53 signaling pathway_Homo sapiens_hsa041151.67779815
28Synaptic vesicle cycle_Homo sapiens_hsa047211.46354552
29Biosynthesis of amino acids_Homo sapiens_hsa012301.45621683
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42660650
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42610267
32Systemic lupus erythematosus_Homo sapiens_hsa053221.34570150
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25636399
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21727125
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.21061937
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.19925428
37Selenocompound metabolism_Homo sapiens_hsa004501.18488949
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18323061
39Cardiac muscle contraction_Homo sapiens_hsa042601.16402180
40Steroid biosynthesis_Homo sapiens_hsa001001.14872680
41Purine metabolism_Homo sapiens_hsa002301.12443595
42Oocyte meiosis_Homo sapiens_hsa041141.11252685
43Epstein-Barr virus infection_Homo sapiens_hsa051691.06851616
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04979405
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03555987
46Viral carcinogenesis_Homo sapiens_hsa052031.02707023
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98924304
48Alzheimers disease_Homo sapiens_hsa050100.97735790
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93094836
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91870406
51Mineral absorption_Homo sapiens_hsa049780.91817444
52Folate biosynthesis_Homo sapiens_hsa007900.88267612
53Hippo signaling pathway_Homo sapiens_hsa043900.86673365
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86452017
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85357354
56Fructose and mannose metabolism_Homo sapiens_hsa000510.84380669
57Vitamin B6 metabolism_Homo sapiens_hsa007500.83304406
58Fatty acid elongation_Homo sapiens_hsa000620.81199693
59Pentose phosphate pathway_Homo sapiens_hsa000300.78822171
60Carbon metabolism_Homo sapiens_hsa012000.78279149
61MicroRNAs in cancer_Homo sapiens_hsa052060.77014037
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76795321
63Vitamin digestion and absorption_Homo sapiens_hsa049770.76683597
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.73366084
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72612771
66TGF-beta signaling pathway_Homo sapiens_hsa043500.67212615
67Basal cell carcinoma_Homo sapiens_hsa052170.64867619
68Notch signaling pathway_Homo sapiens_hsa043300.60035908
69Thyroid cancer_Homo sapiens_hsa052160.57874405
70Antigen processing and presentation_Homo sapiens_hsa046120.57452298
71Glutathione metabolism_Homo sapiens_hsa004800.53838615
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53781722
73Nitrogen metabolism_Homo sapiens_hsa009100.53297228
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.52649118
75Tight junction_Homo sapiens_hsa045300.52327108
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52189318
77Herpes simplex infection_Homo sapiens_hsa051680.52145274
78Peroxisome_Homo sapiens_hsa041460.51667804
79HTLV-I infection_Homo sapiens_hsa051660.51294388
80Alcoholism_Homo sapiens_hsa050340.49386924
81Adherens junction_Homo sapiens_hsa045200.48248083
82Small cell lung cancer_Homo sapiens_hsa052220.46498791
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46081281
84mTOR signaling pathway_Homo sapiens_hsa041500.45260625
85Hedgehog signaling pathway_Homo sapiens_hsa043400.41786486
86Arginine and proline metabolism_Homo sapiens_hsa003300.41510075
87Bladder cancer_Homo sapiens_hsa052190.41445620
88Lysosome_Homo sapiens_hsa041420.40043071
89Phototransduction_Homo sapiens_hsa047440.37788713
90Galactose metabolism_Homo sapiens_hsa000520.37318836
91Colorectal cancer_Homo sapiens_hsa052100.36443738
92N-Glycan biosynthesis_Homo sapiens_hsa005100.34774861
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31689479
94HIF-1 signaling pathway_Homo sapiens_hsa040660.30177972
95Pathways in cancer_Homo sapiens_hsa052000.29269065
96Sulfur relay system_Homo sapiens_hsa041220.29034747
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27064002
98Rheumatoid arthritis_Homo sapiens_hsa053230.25844833
99Linoleic acid metabolism_Homo sapiens_hsa005910.24370560
100Arginine biosynthesis_Homo sapiens_hsa002200.23679914
101Apoptosis_Homo sapiens_hsa042100.23221984
102Huntingtons disease_Homo sapiens_hsa050160.23064670
103Ether lipid metabolism_Homo sapiens_hsa005650.22448993
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21904047
105Lysine degradation_Homo sapiens_hsa003100.19176577
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18377839
107Insulin signaling pathway_Homo sapiens_hsa049100.18115950
108Fat digestion and absorption_Homo sapiens_hsa049750.17927108
109Legionellosis_Homo sapiens_hsa051340.17624410
110Melanoma_Homo sapiens_hsa052180.17186345
111Tryptophan metabolism_Homo sapiens_hsa003800.14791762
112Fatty acid biosynthesis_Homo sapiens_hsa000610.14368377
113Starch and sucrose metabolism_Homo sapiens_hsa005000.14116714
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13795951
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13586262
116Metabolic pathways_Homo sapiens_hsa011000.12749625
117Wnt signaling pathway_Homo sapiens_hsa043100.12309646
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12243711
119beta-Alanine metabolism_Homo sapiens_hsa004100.12110359
120Prostate cancer_Homo sapiens_hsa052150.11126645
121Glucagon signaling pathway_Homo sapiens_hsa049220.11015867
122Prion diseases_Homo sapiens_hsa050200.10600211
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10436958
124Arachidonic acid metabolism_Homo sapiens_hsa005900.09914291
125Regulation of autophagy_Homo sapiens_hsa041400.09866003
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09793129
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.09065142
128Phenylalanine metabolism_Homo sapiens_hsa003600.08749032
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06116328
130Pyruvate metabolism_Homo sapiens_hsa006200.05794387
131Protein export_Homo sapiens_hsa030600.05772575
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05717826
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.05508494
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.01786653
135Renin-angiotensin system_Homo sapiens_hsa046140.01587800
136Inositol phosphate metabolism_Homo sapiens_hsa005620.00793849

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