DNPEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.46222713
2COPI coating of Golgi vesicle (GO:0048205)4.46222713
3formation of translation preinitiation complex (GO:0001731)4.04567285
4cullin deneddylation (GO:0010388)4.02199757
5purine nucleobase biosynthetic process (GO:0009113)3.80595579
6proteasome assembly (GO:0043248)3.78138631
7L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77966683
8proline biosynthetic process (GO:0006561)3.77451469
9protein deneddylation (GO:0000338)3.73091188
10nucleobase biosynthetic process (GO:0046112)3.72515704
11ribosomal small subunit assembly (GO:0000028)3.72207950
12DNA deamination (GO:0045006)3.67816066
13maturation of SSU-rRNA (GO:0030490)3.56024554
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53582259
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50690060
16positive regulation of Cdc42 GTPase activity (GO:0043089)3.48946526
17GDP-mannose metabolic process (GO:0019673)3.45739193
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.40960060
19NIK/NF-kappaB signaling (GO:0038061)3.39836271
20L-methionine salvage (GO:0071267)3.39775993
21L-methionine biosynthetic process (GO:0071265)3.39775993
22amino acid salvage (GO:0043102)3.39775993
23oxidative phosphorylation (GO:0006119)3.39566995
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38295078
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.33827925
26protein retention in ER lumen (GO:0006621)3.31224068
27regulation of mitochondrial translation (GO:0070129)3.28031123
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.26336805
29negative regulation of ligase activity (GO:0051352)3.26336805
30cotranslational protein targeting to membrane (GO:0006613)3.25889694
31protein targeting to ER (GO:0045047)3.25783670
32regulation of cellular amino acid metabolic process (GO:0006521)3.24631844
33DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22178822
34galactose catabolic process (GO:0019388)3.20806642
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20371382
36positive regulation of keratinocyte differentiation (GO:0045618)3.19387086
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.14404380
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.14404380
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11404570
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11404570
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11404570
42protein localization to endoplasmic reticulum (GO:0070972)3.10839744
43negative regulation of cell size (GO:0045792)3.09303522
44pinocytosis (GO:0006907)3.09295813
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08878823
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.07285498
47signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07285498
48viral transcription (GO:0019083)3.07076354
49pteridine-containing compound biosynthetic process (GO:0042559)3.05870735
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05228923
51translational elongation (GO:0006414)3.03839073
52translation (GO:0006412)3.03401074
53ribosomal large subunit biogenesis (GO:0042273)3.02419415
54signal transduction involved in cell cycle checkpoint (GO:0072395)3.02390597
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98056006
56nucleoside salvage (GO:0043174)2.97644414
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97380479
58translational termination (GO:0006415)2.97358589
59angiotensin maturation (GO:0002003)2.93113914
60tricarboxylic acid cycle (GO:0006099)2.92464310
61pentose-phosphate shunt (GO:0006098)2.90453196
62translational initiation (GO:0006413)2.90063345
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88934633
64oxaloacetate metabolic process (GO:0006107)2.88845611
65positive regulation of ligase activity (GO:0051351)2.87329673
66folic acid-containing compound biosynthetic process (GO:0009396)2.85421121
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84150511
68transcription from mitochondrial promoter (GO:0006390)2.83538561
69regulation of vitamin metabolic process (GO:0030656)2.82273235
70regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.81606336
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78136029
72folic acid metabolic process (GO:0046655)2.77263936
73viral mRNA export from host cell nucleus (GO:0046784)2.77164686
74ribosomal small subunit biogenesis (GO:0042274)2.74948005
75fructose metabolic process (GO:0006000)2.74402207
76antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.73707485
77COPII vesicle coating (GO:0048208)2.73627671
78positive regulation of cellular amine metabolic process (GO:0033240)2.73530478
79rRNA modification (GO:0000154)2.72110818
80nucleotide salvage (GO:0043173)2.70654485
81positive regulation of lipoprotein lipase activity (GO:0051006)2.68713002
82positive regulation of triglyceride lipase activity (GO:0061365)2.68713002
83regulation of cholesterol esterification (GO:0010872)2.67658093
84signal peptide processing (GO:0006465)2.67594652
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67116368
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67116368
87antigen processing and presentation of endogenous antigen (GO:0019883)2.67057891
88IMP biosynthetic process (GO:0006188)2.66898012
89regulation of ubiquitin-protein transferase activity (GO:0051438)2.66537691
90methionine biosynthetic process (GO:0009086)2.64546853
91aspartate family amino acid biosynthetic process (GO:0009067)2.64431337
92proline metabolic process (GO:0006560)2.64167142
93positive regulation of cell cycle arrest (GO:0071158)2.63897018
94ATP synthesis coupled proton transport (GO:0015986)2.63574191
95energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63574191
96glucose catabolic process (GO:0006007)2.63403767
97response to type I interferon (GO:0034340)2.62899789
98purine nucleotide salvage (GO:0032261)2.62298305
99negative regulation of viral release from host cell (GO:1902187)2.61784332
100urea cycle (GO:0000050)2.61688366
101type I interferon signaling pathway (GO:0060337)2.60854169
102cellular response to type I interferon (GO:0071357)2.60854169
103peptide catabolic process (GO:0043171)2.59669841
104regulation of ligase activity (GO:0051340)2.59458835
105sexual reproduction (GO:0019953)2.58935325
106branched-chain amino acid catabolic process (GO:0009083)2.58849832
107sulfur amino acid biosynthetic process (GO:0000097)2.58426822
108ribonucleoprotein complex biogenesis (GO:0022613)2.57941962
109nucleobase-containing small molecule interconversion (GO:0015949)2.57792199
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57524495
111negative regulation of erythrocyte differentiation (GO:0045647)2.56675219
112nitrogen cycle metabolic process (GO:0071941)2.53407306
113NADPH regeneration (GO:0006740)2.52427185
114antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.51833792
115viral life cycle (GO:0019058)2.50798853
116NADH metabolic process (GO:0006734)2.50684932
117glycine metabolic process (GO:0006544)2.50411756
118autophagic vacuole fusion (GO:0000046)2.49990529
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48431511
120pentose metabolic process (GO:0019321)2.48262329
121regulation of cholesterol homeostasis (GO:2000188)2.48079878
122DNA replication-dependent nucleosome organization (GO:0034723)2.47962127
123DNA replication-dependent nucleosome assembly (GO:0006335)2.47962127
124intestinal cholesterol absorption (GO:0030299)2.46735397
125mannose metabolic process (GO:0006013)2.45578073
126regulation of type I interferon-mediated signaling pathway (GO:0060338)2.45468687
127ribosome biogenesis (GO:0042254)2.45438647
128spliceosomal snRNP assembly (GO:0000387)2.45277258
129DNA strand elongation involved in DNA replication (GO:0006271)2.45276759
130urea metabolic process (GO:0019627)2.44591175
131DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.44535354
132folic acid transport (GO:0015884)2.44119301
133L-phenylalanine metabolic process (GO:0006558)2.43839511
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43839511
135tRNA aminoacylation for protein translation (GO:0006418)2.43166869
136positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42793347
137amino acid activation (GO:0043038)2.42683811
138tRNA aminoacylation (GO:0043039)2.42683811
139cellular metabolic compound salvage (GO:0043094)2.42406647
140positive regulation of epidermal cell differentiation (GO:0045606)2.41647296
141glucose 6-phosphate metabolic process (GO:0051156)2.41085447
142adhesion of symbiont to host (GO:0044406)2.37829353
143T cell apoptotic process (GO:0070231)2.34108129
144regulation of viral release from host cell (GO:1902186)2.31807828
145tricarboxylic acid metabolic process (GO:0072350)2.30818985
146amyloid precursor protein catabolic process (GO:0042987)2.29888209
147positive regulation of histone deacetylation (GO:0031065)2.28591667
148modulation by symbiont of host cellular process (GO:0044068)2.28134482
149regulation of vitamin D biosynthetic process (GO:0060556)2.26820734
150glutathione biosynthetic process (GO:0006750)2.26231940
151positive regulation of fatty acid biosynthetic process (GO:0045723)2.23331362
152response to peptidoglycan (GO:0032494)2.23059627
153leukocyte apoptotic process (GO:0071887)2.22508947
154adhesion of symbiont to host cell (GO:0044650)2.22485894
155virion attachment to host cell (GO:0019062)2.22485894
156cellular response to virus (GO:0098586)2.22229046
157membrane protein intracellular domain proteolysis (GO:0031293)2.20151403
158glycosphingolipid catabolic process (GO:0046479)2.20132312
159regulation of apoptotic process involved in morphogenesis (GO:1902337)2.19322574
160glutamine family amino acid biosynthetic process (GO:0009084)2.19035984
161interferon-gamma secretion (GO:0072643)2.18532470
162lipopolysaccharide-mediated signaling pathway (GO:0031663)2.18254655
163regulation of cholesterol storage (GO:0010885)2.17947767
164lymphocyte apoptotic process (GO:0070227)2.15033990
165branching involved in mammary gland duct morphogenesis (GO:0060444)2.14993425
166regulation of chemokine biosynthetic process (GO:0045073)2.13985479
167modulation by virus of host process (GO:0019054)2.13495013
168fusion of sperm to egg plasma membrane (GO:0007342)2.13410462
169cellular response to exogenous dsRNA (GO:0071360)2.13378302
170regulation of cholesterol metabolic process (GO:0090181)2.12945838
171cellular response to interferon-beta (GO:0035458)2.12818314
172maternal placenta development (GO:0001893)2.12609572
173negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.09471743
174tumor necrosis factor-mediated signaling pathway (GO:0033209)2.09269147
175nitric oxide biosynthetic process (GO:0006809)2.09147752
176phospholipid efflux (GO:0033700)2.09039848
177fat-soluble vitamin biosynthetic process (GO:0042362)2.08657660
178regulation of necrotic cell death (GO:0010939)2.08184730
179regulation of glucose import in response to insulin stimulus (GO:2001273)2.07189431
180response to interferon-beta (GO:0035456)2.06603288
181endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.06259781
182mRNA modification (GO:0016556)2.05928955
183vagina development (GO:0060068)2.05829014
184nonribosomal peptide biosynthetic process (GO:0019184)2.05440647
185activation of MAPKKK activity (GO:0000185)2.02981901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76832680
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.48244574
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26817009
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21264163
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.06213340
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83133117
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.76946277
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75976481
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74116500
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73707278
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.67378122
12E2F7_22180533_ChIP-Seq_HELA_Human2.59552645
13VDR_21846776_ChIP-Seq_THP-1_Human2.50156687
14LXR_22292898_ChIP-Seq_THP-1_Human2.48580819
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38375099
16* IRF8_22096565_ChIP-ChIP_GC-B_Human2.35774182
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32631506
18E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30199832
19ZNF263_19887448_ChIP-Seq_K562_Human2.25069952
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20527101
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19920282
22XRN2_22483619_ChIP-Seq_HELA_Human2.19020091
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17540217
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16621079
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16191432
26MYC_22102868_ChIP-Seq_BL_Human2.15344316
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07643833
28RACK7_27058665_Chip-Seq_MCF-7_Human2.04177869
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.97252535
30GABP_19822575_ChIP-Seq_HepG2_Human1.95549651
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93416191
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.90618881
33DCP1A_22483619_ChIP-Seq_HELA_Human1.87844613
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.87842556
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86725014
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84466153
37* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83028745
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78207387
39* VDR_23849224_ChIP-Seq_CD4+_Human1.74643764
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73886774
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70671709
42* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70518346
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.70462568
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69817400
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69507177
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.68590032
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68046796
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.65691815
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64665264
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64398580
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59962095
52P68_20966046_ChIP-Seq_HELA_Human1.58715029
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58005597
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57812592
55FOXP3_21729870_ChIP-Seq_TREG_Human1.57368272
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54599312
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51855731
58TCF7_22412390_ChIP-Seq_EML_Mouse1.51762211
59TTF2_22483619_ChIP-Seq_HELA_Human1.49465024
60VDR_24763502_ChIP-Seq_THP-1_Human1.48223017
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.48152390
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47945674
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.46714999
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45645188
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44915064
66* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.44671707
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44176212
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44038662
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43797495
70BCOR_27268052_Chip-Seq_Bcells_Human1.43538154
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43510239
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43154786
73BCL6_27268052_Chip-Seq_Bcells_Human1.42086683
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40585172
75MAF_26560356_Chip-Seq_TH1_Human1.39473267
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38721926
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.37733153
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34290074
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33759538
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33600868
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33045163
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32451895
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32129661
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.30635913
85NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29912890
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29762554
87MAF_26560356_Chip-Seq_TH2_Human1.29325469
88KDM2B_26808549_Chip-Seq_DND41_Human1.27652639
89ATF3_27146783_Chip-Seq_COLON_Human1.27189786
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26249075
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26247098
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25777043
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24123228
94SMC4_20622854_ChIP-Seq_HELA_Human1.23584400
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23474322
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23373813
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22502883
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.21705400
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.21445503
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21415704
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20737509
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20696687
103UTX_26944678_Chip-Seq_JUKART_Human1.20473480
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19872998
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19642789
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19609868
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19405872
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19277735
109NCOR1_26117541_ChIP-Seq_K562_Human1.18254169
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17437022
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16276389
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16237688
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15940939
114* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15731772
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.15675730
116* CTCF_26484167_Chip-Seq_Bcells_Mouse1.15278441
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15276457
118KDM5A_27292631_Chip-Seq_BREAST_Human1.14906071
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14789496
120TFEB_21752829_ChIP-Seq_HELA_Human1.12919803
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.12489774
122RUNX1_22412390_ChIP-Seq_EML_Mouse1.12289197
123* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10689281
124ELK1_19687146_ChIP-ChIP_HELA_Human1.10514495
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10318276
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10185820
127CIITA_25753668_ChIP-Seq_RAJI_Human1.09483700
128CLOCK_20551151_ChIP-Seq_293T_Human1.08976090
129E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08794318
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08182981
131* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07900309
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07704220
133HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07031474
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07011730
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06834209
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06112403
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05802846
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05742743
139TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05223711
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04850054
141SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04445062
142E2F1_20622854_ChIP-Seq_HELA_Human1.03356499
143NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03235409
144TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03118987
145* CTCF_21964334_Chip-Seq_Bcells_Human1.03080784
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01686094
147AR_21909140_ChIP-Seq_LNCAP_Human1.01425553
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00566872
149PHF8_20622854_ChIP-Seq_HELA_Human1.00478362
150SOX17_20123909_ChIP-Seq_XEN_Mouse1.00072279
151ETS1_21867929_ChIP-Seq_TH2_Mouse0.99758345
152* RARB_24833708_ChIP-Seq_LIVER_Mouse0.98776699
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98494536
154* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97466737
155MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97154179
156CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96952817
157SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96626526
158* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96517703
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96295303
160YY1_22570637_ChIP-Seq_MALME-3M_Human0.96248345
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95671818
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.92470298
163FOXP1_21924763_ChIP-Seq_HESCs_Human0.91619011
164ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89913690
165KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88316590
166KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88316590

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.10096768
2MP0005451_abnormal_body_composition3.68781533
3MP0003693_abnormal_embryo_hatching3.07480353
4MP0001873_stomach_inflammation2.48342462
5MP0010030_abnormal_orbit_morphology2.45567797
6MP0008438_abnormal_cutaneous_collagen2.43516724
7MP0005365_abnormal_bile_salt2.38338420
8MP0004957_abnormal_blastocyst_morpholog2.34398766
9MP0003191_abnormal_cellular_cholesterol2.21788719
10MP0005360_urolithiasis2.19914851
11MP0002139_abnormal_hepatobiliary_system2.11075390
12MP0005085_abnormal_gallbladder_physiolo2.10857326
13MP0003186_abnormal_redox_activity2.03554427
14MP0001666_abnormal_nutrient_absorption1.99864520
15MP0006054_spinal_hemorrhage1.93244267
16MP0009840_abnormal_foam_cell1.87990009
17MP0003436_decreased_susceptibility_to1.84413667
18MP0003123_paternal_imprinting1.81640813
19MP0009278_abnormal_bone_marrow1.78732899
20MP0002653_abnormal_ependyma_morphology1.78619740
21MP0010155_abnormal_intestine_physiology1.76877190
22MP0008260_abnormal_autophagy1.71037399
23MP0005410_abnormal_fertilization1.67623273
24MP0001835_abnormal_antigen_presentation1.66773814
25MP0001849_ear_inflammation1.64655433
26MP0005083_abnormal_biliary_tract1.64611180
27MP0010234_abnormal_vibrissa_follicle1.63898706
28MP0004264_abnormal_extraembryonic_tissu1.62343557
29MP0002796_impaired_skin_barrier1.61759461
30MP0003303_peritoneal_inflammation1.61204198
31MP0005220_abnormal_exocrine_pancreas1.60614101
32MP0002138_abnormal_hepatobiliary_system1.58937467
33MP0003763_abnormal_thymus_physiology1.58285923
34MP0008007_abnormal_cellular_replicative1.56205526
35MP0004185_abnormal_adipocyte_glucose1.55695405
36MP0003705_abnormal_hypodermis_morpholog1.55109692
37MP0009785_altered_susceptibility_to1.54287108
38MP0008932_abnormal_embryonic_tissue1.53269518
39MP0006036_abnormal_mitochondrial_physio1.52414558
40MP0005666_abnormal_adipose_tissue1.52360772
41MP0005025_abnormal_response_to1.51654897
42MP0010352_gastrointestinal_tract_polyps1.51079820
43MP0004947_skin_inflammation1.48008149
44MP0002148_abnormal_hypersensitivity_rea1.47558648
45MP0003077_abnormal_cell_cycle1.47295650
46MP0005084_abnormal_gallbladder_morpholo1.45267236
47MP0001764_abnormal_homeostasis1.42982510
48MP0001730_embryonic_growth_arrest1.41153097
49MP0000685_abnormal_immune_system1.39891516
50MP0005387_immune_system_phenotype1.38746929
51MP0001790_abnormal_immune_system1.38746929
52MP0003111_abnormal_nucleus_morphology1.36641790
53MP0003279_aneurysm1.34284080
54MP0005332_abnormal_amino_acid1.30646826
55MP0003195_calcinosis1.29597820
56MP0008875_abnormal_xenobiotic_pharmacok1.29309352
57MP0004084_abnormal_cardiac_muscle1.28347693
58MP0002254_reproductive_system_inflammat1.26849206
59MP0000013_abnormal_adipose_tissue1.25933156
60MP0004019_abnormal_vitamin_homeostasis1.25681553
61MP0002166_altered_tumor_susceptibility1.24919926
62MP0003119_abnormal_digestive_system1.23385291
63MP0005000_abnormal_immune_tolerance1.22038885
64MP0003453_abnormal_keratinocyte_physiol1.21857661
65MP0009643_abnormal_urine_homeostasis1.21023157
66MP0005275_abnormal_skin_tensile1.20704279
67MP0009053_abnormal_anal_canal1.20613217
68MP0003567_abnormal_fetal_cardiomyocyte1.19320408
69MP0010368_abnormal_lymphatic_system1.19101944
70MP0002269_muscular_atrophy1.18750257
71MP0004133_heterotaxia1.18518740
72MP0005076_abnormal_cell_differentiation1.18048632
73MP0008058_abnormal_DNA_repair1.18022926
74MP0001756_abnormal_urination1.17236774
75MP0000749_muscle_degeneration1.17202548
76MP0005397_hematopoietic_system_phenotyp1.16877633
77MP0001545_abnormal_hematopoietic_system1.16877633
78MP0001853_heart_inflammation1.15960692
79MP0004233_abnormal_muscle_weight1.15422982
80MP0008469_abnormal_protein_level1.14675229
81MP0005670_abnormal_white_adipose1.13728832
82MP0004510_myositis1.11763986
83MP0001845_abnormal_inflammatory_respons1.11758042
84MP0004043_abnormal_pH_regulation1.11694138
85MP0003172_abnormal_lysosome_physiology1.10254420
86MP0001533_abnormal_skeleton_physiology1.09849303
87MP0003183_abnormal_peptide_metabolism1.09626848
88MP0005319_abnormal_enzyme/_coenzyme1.08550616
89MP0003786_premature_aging1.08175394
90MP0005375_adipose_tissue_phenotype1.07956565
91MP0000358_abnormal_cell_content/1.07728222
92MP0005501_abnormal_skin_physiology1.07579118
93MP0005671_abnormal_response_to1.07385797
94MP0001800_abnormal_humoral_immune1.07044871
95MP0002419_abnormal_innate_immunity1.06869205
96MP0001697_abnormal_embryo_size1.06383109
97MP0003718_maternal_effect1.06153936
98MP0003984_embryonic_growth_retardation1.04941361
99MP0010094_abnormal_chromosome_stability1.04672734
100MP0002452_abnormal_antigen_presenting1.04595573
101MP0002723_abnormal_immune_serum1.04581052
102MP0002088_abnormal_embryonic_growth/wei1.04456082
103MP0003283_abnormal_digestive_organ1.02609484
104MP0005380_embryogenesis_phenotype1.02410521
105MP0001672_abnormal_embryogenesis/_devel1.02410521
106MP0002080_prenatal_lethality1.02019497
107MP0000750_abnormal_muscle_regeneration1.00653897
108MP0004272_abnormal_basement_membrane0.99250222
109MP0005266_abnormal_metabolism0.99122235
110MP0005503_abnormal_tendon_morphology0.97626244
111MP0005464_abnormal_platelet_physiology0.97370954
112MP0001881_abnormal_mammary_gland0.96959650
113MP0009384_cardiac_valve_regurgitation0.95621881
114MP0003075_altered_response_to0.94914878
115MP0003315_abnormal_perineum_morphology0.94839075
116MP0001727_abnormal_embryo_implantation0.94707138
117MP0002396_abnormal_hematopoietic_system0.94683129
118MP0005166_decreased_susceptibility_to0.93972883
119MP0001819_abnormal_immune_cell0.93556204
120MP0003300_gastrointestinal_ulcer0.93494253
121MP0000678_abnormal_parathyroid_gland0.92809318
122MP0006035_abnormal_mitochondrial_morpho0.92578353
123MP0009115_abnormal_fat_cell0.92404126
124MP0002420_abnormal_adaptive_immunity0.91996320
125MP0004782_abnormal_surfactant_physiolog0.91486917
126MP0005408_hypopigmentation0.90780153
127MP0009697_abnormal_copulation0.90504766
128MP0005023_abnormal_wound_healing0.90255212
129MP0010329_abnormal_lipoprotein_level0.89613536
130MP0000858_altered_metastatic_potential0.89023391
131MP0003566_abnormal_cell_adhesion0.88858898
132MP0000598_abnormal_liver_morphology0.88716280
133MP0002060_abnormal_skin_morphology0.88281292
134MP0000490_abnormal_crypts_of0.88015020
135MP0002132_abnormal_respiratory_system0.86494136
136MP0003221_abnormal_cardiomyocyte_apopto0.86339565
137MP0009333_abnormal_splenocyte_physiolog0.86312934
138MP0002837_dystrophic_cardiac_calcinosis0.85878404
139MP0001216_abnormal_epidermal_layer0.85332203
140MP0003866_abnormal_defecation0.84975500
141MP0002877_abnormal_melanocyte_morpholog0.84273402
142MP0001348_abnormal_lacrimal_gland0.84147511
143MP0003011_delayed_dark_adaptation0.83652396
144MP0002098_abnormal_vibrissa_morphology0.83157470
145MP0000609_abnormal_liver_physiology0.83107362
146MP0002118_abnormal_lipid_homeostasis0.82383664
147MP0003942_abnormal_urinary_system0.82309486
148MP0005330_cardiomyopathy0.81889592
149MP0001663_abnormal_digestive_system0.81845104
150MP0000681_abnormal_thyroid_gland0.81743445
151MP0002398_abnormal_bone_marrow0.81199710
152MP0000462_abnormal_digestive_system0.81026781
153MP0009931_abnormal_skin_appearance0.80328926
154MP0002127_abnormal_cardiovascular_syste0.79794255
155MP0002085_abnormal_embryonic_tissue0.79419914
156MP0000716_abnormal_immune_system0.79310104
157MP0002429_abnormal_blood_cell0.78920848
158MP0002086_abnormal_extraembryonic_tissu0.77966895
159MP0002998_abnormal_bone_remodeling0.77785250
160MP0003890_abnormal_embryonic-extraembry0.77563932
161MP0009780_abnormal_chondrocyte_physiolo0.77335482
162MP0005376_homeostasis/metabolism_phenot0.77179714
163MP0003252_abnormal_bile_duct0.77112738
164MP0000350_abnormal_cell_proliferation0.76963466
165MP0001542_abnormal_bone_strength0.76850849
166MP0005058_abnormal_lysosome_morphology0.76081075
167MP0005257_abnormal_intraocular_pressure0.75667226
168MP0002295_abnormal_pulmonary_circulatio0.75526598
169MP0004197_abnormal_fetal_growth/weight/0.75270053
170MP0001243_abnormal_dermal_layer0.75052164
171MP0005584_abnormal_enzyme/coenzyme_acti0.74491765
172MP0000003_abnormal_adipose_tissue0.74345010
173MP0000343_altered_response_to0.73615631
174MP0005636_abnormal_mineral_homeostasis0.73393505
175MP0002970_abnormal_white_adipose0.73102038
176MP0002722_abnormal_immune_system0.71752445

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.10669296
2Multiple enchondromatosis (HP:0005701)3.44066478
3Hepatic necrosis (HP:0002605)3.43075666
4Asymmetric septal hypertrophy (HP:0001670)3.19302083
5J-shaped sella turcica (HP:0002680)3.12225535
6Abnormality of fatty-acid metabolism (HP:0004359)3.11761626
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09194192
8Systemic lupus erythematosus (HP:0002725)3.08334158
9Abnormality of the anterior horn cell (HP:0006802)2.98691363
10Degeneration of anterior horn cells (HP:0002398)2.98691363
11Dicarboxylic aciduria (HP:0003215)2.97056045
12Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97056045
13Distal lower limb muscle weakness (HP:0009053)2.88426892
14Hepatocellular necrosis (HP:0001404)2.78265502
15Hyperglycinuria (HP:0003108)2.78104822
16Hyperglycinemia (HP:0002154)2.73520811
17Aplastic anemia (HP:0001915)2.72443496
18Thin bony cortex (HP:0002753)2.69210637
19Generalized aminoaciduria (HP:0002909)2.65021246
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63697024
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63697024
22Trismus (HP:0000211)2.63178588
23Protrusio acetabuli (HP:0003179)2.63025435
24Deep venous thrombosis (HP:0002625)2.61811080
25Cerebral hypomyelination (HP:0006808)2.60192527
26Hyperinsulinemic hypoglycemia (HP:0000825)2.60184339
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59840224
28Opisthotonus (HP:0002179)2.59626908
29Ketosis (HP:0001946)2.57450268
30Hypobetalipoproteinemia (HP:0003563)2.56143021
31Increased serum pyruvate (HP:0003542)2.55786035
32Abnormality of glycolysis (HP:0004366)2.55786035
33Ketoacidosis (HP:0001993)2.53679412
34Secondary amenorrhea (HP:0000869)2.52186185
35Type I transferrin isoform profile (HP:0003642)2.52122294
36Abnormal gallbladder physiology (HP:0012438)2.50791257
37Cholecystitis (HP:0001082)2.50791257
38Dysostosis multiplex (HP:0000943)2.50663790
39Proximal tubulopathy (HP:0000114)2.49929765
40Myopathic facies (HP:0002058)2.49686738
41Abnormality of serine family amino acid metabolism (HP:0010894)2.49326597
42Abnormality of glycine metabolism (HP:0010895)2.49326597
43Palpitations (HP:0001962)2.47175076
44Increased cerebral lipofuscin (HP:0011813)2.46452041
45Rhabdomyolysis (HP:0003201)2.44143265
46Hyperglycemia (HP:0003074)2.43817787
47Vacuolated lymphocytes (HP:0001922)2.43735557
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.43304260
49Late onset (HP:0003584)2.43033938
50Mitochondrial inheritance (HP:0001427)2.42664163
51Increased serum lactate (HP:0002151)2.42039795
52Lethargy (HP:0001254)2.41824118
53Increased CSF lactate (HP:0002490)2.39377581
54Increased serum ferritin (HP:0003281)2.36642922
55Bulbar palsy (HP:0001283)2.36543831
56Acute necrotizing encephalopathy (HP:0006965)2.36476165
57Hyperammonemia (HP:0001987)2.35480553
58CNS demyelination (HP:0007305)2.34743142
59Hypoglycemic seizures (HP:0002173)2.33815408
60Hypertensive crisis (HP:0100735)2.31396170
61Abnormal protein glycosylation (HP:0012346)2.31358088
62Abnormal glycosylation (HP:0012345)2.31358088
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31358088
64Abnormal protein N-linked glycosylation (HP:0012347)2.31358088
65Hemorrhage of the eye (HP:0011885)2.31164855
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30839980
67Abnormal mitochondria in muscle tissue (HP:0008316)2.30781829
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30390957
69Stridor (HP:0010307)2.30163870
70Microvesicular hepatic steatosis (HP:0001414)2.29422367
71Ileus (HP:0002595)2.28944078
72Exercise-induced myalgia (HP:0003738)2.28811949
73Neoplasm of the adrenal gland (HP:0100631)2.28271327
74Acute encephalopathy (HP:0006846)2.27832595
75Myoglobinuria (HP:0002913)2.25644705
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.25010243
77Diaphragmatic weakness (HP:0009113)2.23479809
78Pancreatic islet-cell hyperplasia (HP:0004510)2.20422664
79Abdominal distention (HP:0003270)2.18593702
80Nonimmune hydrops fetalis (HP:0001790)2.17855800
81Cerebral edema (HP:0002181)2.16879147
82Lactic acidosis (HP:0003128)2.16564840
83Abnormality of the pancreatic islet cells (HP:0006476)2.16217306
84Abnormality of endocrine pancreas physiology (HP:0012093)2.16217306
85Right ventricular cardiomyopathy (HP:0011663)2.15426535
86Abnormal cartilage morphology (HP:0002763)2.13724395
87Prolonged neonatal jaundice (HP:0006579)2.12679037
88Colitis (HP:0002583)2.12455521
89Abnormality of glycolipid metabolism (HP:0010969)2.11160004
90Abnormality of liposaccharide metabolism (HP:0010968)2.11160004
91Abnormality of glycosphingolipid metabolism (HP:0004343)2.11160004
92Selective tooth agenesis (HP:0001592)2.10773915
93Abnormal hemoglobin (HP:0011902)2.10772359
94Seborrheic dermatitis (HP:0001051)2.10622234
95Abnormal pancreas size (HP:0012094)2.10365227
96Nausea (HP:0002018)2.09597835
97Rough bone trabeculation (HP:0100670)2.09472500
98Loss of speech (HP:0002371)2.09399567
99Abnormality of urine glucose concentration (HP:0011016)2.07831248
100Glycosuria (HP:0003076)2.07831248
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06850796
102Mucopolysacchariduria (HP:0008155)2.06208649
103Urinary glycosaminoglycan excretion (HP:0003541)2.06208649
104Glomerulonephritis (HP:0000099)2.04435188
10511 pairs of ribs (HP:0000878)2.04308642
106Abnormality of polysaccharide metabolism (HP:0011012)2.04004833
107Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04004833
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04004833
109Asymmetry of the thorax (HP:0001555)2.03426684
110Premature ovarian failure (HP:0008209)2.03043149
111B lymphocytopenia (HP:0010976)2.02389541
112Interstitial pulmonary disease (HP:0006530)2.01198216
113Premature rupture of membranes (HP:0001788)2.00754209
114Emotional lability (HP:0000712)1.99971522
115Ragged-red muscle fibers (HP:0003200)1.99203844
116Achilles tendon contracture (HP:0001771)1.98956932
117Beaking of vertebral bodies (HP:0004568)1.98575408
118Microretrognathia (HP:0000308)1.98080780
119Polygenic inheritance (HP:0010982)1.97325960
120Hyperparathyroidism (HP:0000843)1.96866303
121Lipid accumulation in hepatocytes (HP:0006561)1.95987289
122Testicular atrophy (HP:0000029)1.95973651
123Abnormality of complement system (HP:0005339)1.95870144
124Flat acetabular roof (HP:0003180)1.95616036
125Progressive muscle weakness (HP:0003323)1.94561082
126Hypophosphatemia (HP:0002148)1.92840449
127Abnormality of the Achilles tendon (HP:0005109)1.91759389
128Recurrent viral infections (HP:0004429)1.91097100
129Vertebral compression fractures (HP:0002953)1.89706190
130Malnutrition (HP:0004395)1.89237872
131Abnormality of proline metabolism (HP:0010907)1.89091626
132Hydroxyprolinuria (HP:0003080)1.89091626
133Respiratory failure (HP:0002878)1.88828174
134Thrombocytosis (HP:0001894)1.88414004
135Cervical subluxation (HP:0003308)1.88125066
136Carpal bone hypoplasia (HP:0001498)1.87929549
137Abnormality of macrophages (HP:0004311)1.86915730
138Increased intramyocellular lipid droplets (HP:0012240)1.86859904
139Villous atrophy (HP:0011473)1.85573804
140Abnormality of small intestinal villus morphology (HP:0011472)1.85573804
141Neuroendocrine neoplasm (HP:0100634)1.84967410
142Gout (HP:0001997)1.84848591
143Gastrointestinal stroma tumor (HP:0100723)1.84761382
144Hypertriglyceridemia (HP:0002155)1.84372521
145Exercise intolerance (HP:0003546)1.83152021
146Abnormality of the intrinsic pathway (HP:0010989)1.82997538
147Breast hypoplasia (HP:0003187)1.82406240
148Axonal loss (HP:0003447)1.80662202
149Complement deficiency (HP:0004431)1.80448613
150Abnormality of B cell number (HP:0010975)1.79754494
151Redundant skin (HP:0001582)1.79537094
152Abnormality of serum amino acid levels (HP:0003112)1.79393757
153Hyperacusis (HP:0010780)1.79071372
154Reticulocytosis (HP:0001923)1.76890545
1553-Methylglutaconic aciduria (HP:0003535)1.76618872
156Pheochromocytoma (HP:0002666)1.76225059
157Missing ribs (HP:0000921)1.75505788
158Vomiting (HP:0002013)1.75272500
159Poor head control (HP:0002421)1.74746231
160Petechiae (HP:0000967)1.74706400
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74131677
162Methylmalonic aciduria (HP:0012120)1.73393581
163Obstructive lung disease (HP:0006536)1.73355568
164Chronic obstructive pulmonary disease (HP:0006510)1.73355568
165Gastrointestinal inflammation (HP:0004386)1.72109392
166Reticulocytopenia (HP:0001896)1.72005180
167Abnormal enzyme/coenzyme activity (HP:0012379)1.71785657
168Gastrointestinal dysmotility (HP:0002579)1.71751146
169Increased muscle lipid content (HP:0009058)1.71601259
170Abnormality of iron homeostasis (HP:0011031)1.70977616
171Elevated alkaline phosphatase (HP:0003155)1.69065898
172Abnormality of alkaline phosphatase activity (HP:0004379)1.67348210
173Eczematoid dermatitis (HP:0000976)1.67227199
174Distal upper limb amyotrophy (HP:0007149)1.66721027
175Upper limb amyotrophy (HP:0009129)1.66721027
176Elevated erythrocyte sedimentation rate (HP:0003565)1.64137817
177Easy fatigability (HP:0003388)1.63748452
178Abnormality of the nasal mucosa (HP:0000433)1.62761037
179Abnormal trabecular bone morphology (HP:0100671)1.61064189
180Esophageal varix (HP:0002040)1.60769869
181Mildly elevated creatine phosphokinase (HP:0008180)1.60593360
182Abnormality of the thoracic spine (HP:0100711)1.60587708
183Panhypogammaglobulinemia (HP:0003139)1.59534010
184Emphysema (HP:0002097)1.59462465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.06017313
2BUB13.47342834
3EIF2AK13.06235473
4SMG13.04418434
5ERN12.96969614
6PASK2.91103903
7TESK12.60097608
8MAP4K12.53661995
9STK162.53564303
10SIK12.49189978
11NME22.33287282
12EPHA22.18650321
13TBK12.09928078
14FLT32.07054326
15FGFR42.03214657
16PRPF4B2.01176111
17PDK41.95059546
18PDK31.95059546
19TESK21.87625537
20PIK3CG1.85452993
21WEE11.81448108
22EIF2AK31.79941303
23STK38L1.72900946
24DYRK31.68389713
25NEK11.67720608
26MST1R1.66975406
27TRIB31.60688420
28VRK21.60511788
29TLK11.59543798
30PDK21.57090586
31LIMK11.55709431
32RIPK11.55581918
33MYLK1.54076038
34MAP3K111.53631064
35NME11.49015286
36NEK91.47699451
37EEF2K1.40204280
38WNK31.39866469
39MAP3K101.36884860
40RPS6KB21.34865070
41TYK21.30484314
42PIM21.28117737
43MUSK1.26306899
44PAK41.24801934
45RPS6KA41.24511358
46ICK1.22089855
47MAP2K21.21641833
48IKBKE1.16883725
49KDR1.15106710
50PDPK11.14956245
51PKN21.12954804
52MAPKAPK31.12287429
53ILK1.08219250
54MAPK151.08105581
55MAP3K141.07194052
56IKBKB1.04195600
57EPHB21.03589543
58TSSK61.01787906
59MAP3K10.99877555
60MAP3K30.99337267
61CDK70.99280954
62PRKD20.98642420
63LATS20.98037946
64ZAK0.96352981
65PRKCI0.96322460
66RIPK40.95815863
67LMTK20.95069885
68TAOK10.93938285
69PTK60.92746036
70BRAF0.92531682
71OBSCN0.92459061
72AURKA0.91872446
73PLK10.91607121
74MET0.90739236
75TTN0.90486578
76NEK20.90089429
77RPS6KC10.87802382
78RPS6KL10.87802382
79AURKB0.85870548
80MAP3K130.85418924
81GRK60.85232541
82PLK40.85034957
83AKT30.84891188
84DYRK1B0.83909431
85TGFBR10.83623081
86TTK0.82029746
87JAK30.80480668
88IRAK30.80375680
89PAK10.79643494
90RPS6KA20.79234314
91CDK40.78364576
92PTK20.78265256
93ZAP700.74291297
94PDK10.74227319
95DYRK20.73011066
96CHUK0.70956364
97CDK120.69902096
98BRSK20.69294956
99ARAF0.68478199
100MAP3K80.66577370
101DAPK30.66396973
102ABL20.66233913
103RPS6KA60.65758455
104LRRK20.65460131
105MAP2K30.65366451
106HIPK20.65079071
107PRKG20.61680236
108PDGFRA0.61524733
109CSF1R0.61354069
110VRK10.60727955
111SCYL20.60515505
112INSRR0.58638197
113CSNK2A10.55860146
114TIE10.55282641
115CHEK20.54901920
116NLK0.53880526
117DDR20.53792474
118ATR0.52740099
119CDC42BPA0.52618823
120NUAK10.52011870
121PAK20.51774130
122DAPK10.51047552
123IRAK40.49971599
124EPHB10.49263762
125MAP2K10.48249080
126MAP2K60.48086810
127SRPK10.47579161
128PBK0.47136202
129PAK30.46261258
130BMX0.45095879
131MTOR0.43040520
132MAPK70.40945998
133PRKD30.40678342
134TNK20.40555306
135CDK90.39206961
136BTK0.38705033
137PINK10.38541813
138KIT0.38328330
139CSNK2A20.37747445
140MAP3K120.37532082
141BRSK10.37383490
142IRAK20.36658423
143PIK3CA0.36491761
144MATK0.36470995
145FGFR30.35037350
146FER0.34814057
147SIK30.34476134
148PLK30.33104547
149MST40.32965875
150CAMK2G0.32537977
151MAPK110.32119742
152ERBB30.31368216
153MAPK40.30792044
154TAOK20.30365548
155MAPKAPK20.30028702
156RPS6KA10.28398465
157DMPK0.27148205

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.49633812
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.70759712
3Ribosome_Homo sapiens_hsa030102.64037014
4Protein export_Homo sapiens_hsa030602.59631107
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.29045296
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.23288628
7DNA replication_Homo sapiens_hsa030302.11056667
8Folate biosynthesis_Homo sapiens_hsa007902.07286908
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98427069
10RNA polymerase_Homo sapiens_hsa030201.96085891
11Mismatch repair_Homo sapiens_hsa034301.93367834
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82826284
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.81445217
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80808901
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.79317451
16Selenocompound metabolism_Homo sapiens_hsa004501.79274892
17Carbon metabolism_Homo sapiens_hsa012001.75562984
18Pyrimidine metabolism_Homo sapiens_hsa002401.73201002
19Fatty acid degradation_Homo sapiens_hsa000711.71992193
20Parkinsons disease_Homo sapiens_hsa050121.66554930
21Base excision repair_Homo sapiens_hsa034101.64158058
22Biosynthesis of amino acids_Homo sapiens_hsa012301.62000353
23One carbon pool by folate_Homo sapiens_hsa006701.60489648
24Acute myeloid leukemia_Homo sapiens_hsa052211.58466300
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55671523
26Galactose metabolism_Homo sapiens_hsa000521.53190404
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.51580221
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50753378
29Sulfur metabolism_Homo sapiens_hsa009201.49572133
30Oxidative phosphorylation_Homo sapiens_hsa001901.48760376
31Propanoate metabolism_Homo sapiens_hsa006401.48724331
32Pyruvate metabolism_Homo sapiens_hsa006201.48523300
33Fructose and mannose metabolism_Homo sapiens_hsa000511.47979781
34Fat digestion and absorption_Homo sapiens_hsa049751.46903195
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.44741614
36RNA transport_Homo sapiens_hsa030131.44370548
37Allograft rejection_Homo sapiens_hsa053301.38994844
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38838081
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38535121
40Pentose phosphate pathway_Homo sapiens_hsa000301.36872381
41Spliceosome_Homo sapiens_hsa030401.35182911
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34840110
43Nucleotide excision repair_Homo sapiens_hsa034201.33812583
44Sulfur relay system_Homo sapiens_hsa041221.32862716
45Glutathione metabolism_Homo sapiens_hsa004801.32093550
46Lysosome_Homo sapiens_hsa041421.28591673
47Insulin resistance_Homo sapiens_hsa049311.24115248
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.21169405
49Huntingtons disease_Homo sapiens_hsa050161.21104928
50Hepatitis C_Homo sapiens_hsa051601.20092014
51Renin-angiotensin system_Homo sapiens_hsa046141.18283073
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18019807
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.12022503
54Tryptophan metabolism_Homo sapiens_hsa003801.07213238
55Fatty acid metabolism_Homo sapiens_hsa012121.07143077
56Autoimmune thyroid disease_Homo sapiens_hsa053201.05194411
57Influenza A_Homo sapiens_hsa051641.05079441
58Arginine and proline metabolism_Homo sapiens_hsa003301.04948791
59Antigen processing and presentation_Homo sapiens_hsa046121.04850781
60Homologous recombination_Homo sapiens_hsa034401.04817470
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.04719600
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03079787
63Primary immunodeficiency_Homo sapiens_hsa053401.02961856
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.01710759
65Graft-versus-host disease_Homo sapiens_hsa053321.00150073
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99980831
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97902553
68N-Glycan biosynthesis_Homo sapiens_hsa005100.96199427
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.95612403
70B cell receptor signaling pathway_Homo sapiens_hsa046620.94800060
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94296952
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94270684
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92986006
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91760888
75Peroxisome_Homo sapiens_hsa041460.90879092
76Asthma_Homo sapiens_hsa053100.90033298
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89944512
78Herpes simplex infection_Homo sapiens_hsa051680.89783933
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89779697
80Purine metabolism_Homo sapiens_hsa002300.89282301
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87962993
82Leishmaniasis_Homo sapiens_hsa051400.85835149
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.85124486
84Caffeine metabolism_Homo sapiens_hsa002320.85097277
85Chemical carcinogenesis_Homo sapiens_hsa052040.83259942
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.81078294
87Fatty acid elongation_Homo sapiens_hsa000620.80829466
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79261224
89Staphylococcus aureus infection_Homo sapiens_hsa051500.79058071
90Fatty acid biosynthesis_Homo sapiens_hsa000610.78330389
91Butanoate metabolism_Homo sapiens_hsa006500.77497002
92TNF signaling pathway_Homo sapiens_hsa046680.77282681
93Metabolic pathways_Homo sapiens_hsa011000.76368339
94Alzheimers disease_Homo sapiens_hsa050100.76328166
95Cell cycle_Homo sapiens_hsa041100.76104405
96Tyrosine metabolism_Homo sapiens_hsa003500.75360311
97VEGF signaling pathway_Homo sapiens_hsa043700.74896687
98Viral myocarditis_Homo sapiens_hsa054160.74785943
99Starch and sucrose metabolism_Homo sapiens_hsa005000.74597448
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.73112425
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72466403
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70749086
103RNA degradation_Homo sapiens_hsa030180.70424221
104p53 signaling pathway_Homo sapiens_hsa041150.70271391
105Insulin signaling pathway_Homo sapiens_hsa049100.70190853
106Type I diabetes mellitus_Homo sapiens_hsa049400.69663345
107Phenylalanine metabolism_Homo sapiens_hsa003600.69206770
108Arachidonic acid metabolism_Homo sapiens_hsa005900.68056352
109Chronic myeloid leukemia_Homo sapiens_hsa052200.67550681
110Basal transcription factors_Homo sapiens_hsa030220.67396242
111Vitamin digestion and absorption_Homo sapiens_hsa049770.66949809
112Non-homologous end-joining_Homo sapiens_hsa034500.66763970
113Toxoplasmosis_Homo sapiens_hsa051450.65113131
114Osteoclast differentiation_Homo sapiens_hsa043800.64304345
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63745162
116Measles_Homo sapiens_hsa051620.61120463
117Histidine metabolism_Homo sapiens_hsa003400.60706518
118beta-Alanine metabolism_Homo sapiens_hsa004100.60701250
119PPAR signaling pathway_Homo sapiens_hsa033200.60646130
120Legionellosis_Homo sapiens_hsa051340.58988632
121Hepatitis B_Homo sapiens_hsa051610.58160645
122Pertussis_Homo sapiens_hsa051330.57437452
123Other glycan degradation_Homo sapiens_hsa005110.57318146
124Regulation of autophagy_Homo sapiens_hsa041400.57191240
125Prion diseases_Homo sapiens_hsa050200.55780893
126AMPK signaling pathway_Homo sapiens_hsa041520.52454660
127Mineral absorption_Homo sapiens_hsa049780.52138808
128Thyroid cancer_Homo sapiens_hsa052160.51797697
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51490511
130Apoptosis_Homo sapiens_hsa042100.49288538
131Complement and coagulation cascades_Homo sapiens_hsa046100.48411061
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47804659
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47111683
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.46340057
135Non-small cell lung cancer_Homo sapiens_hsa052230.45933195
136Arginine biosynthesis_Homo sapiens_hsa002200.45587910
137Sphingolipid metabolism_Homo sapiens_hsa006000.45444005
138Retinol metabolism_Homo sapiens_hsa008300.44422478
139Linoleic acid metabolism_Homo sapiens_hsa005910.43639685
140Vitamin B6 metabolism_Homo sapiens_hsa007500.42788998
141Steroid biosynthesis_Homo sapiens_hsa001000.42674018
142Epstein-Barr virus infection_Homo sapiens_hsa051690.42657878
143Tuberculosis_Homo sapiens_hsa051520.42656558
144Prolactin signaling pathway_Homo sapiens_hsa049170.41206655
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40698736
146Shigellosis_Homo sapiens_hsa051310.40305002
147Bladder cancer_Homo sapiens_hsa052190.39543035
148mRNA surveillance pathway_Homo sapiens_hsa030150.39027611
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38039480
150Vibrio cholerae infection_Homo sapiens_hsa051100.36031434
151Cardiac muscle contraction_Homo sapiens_hsa042600.32107558
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30394353

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