DNPH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.05935201
2DNA deamination (GO:0045006)5.77557248
3DNA strand elongation involved in DNA replication (GO:0006271)5.28553304
4telomere maintenance via semi-conservative replication (GO:0032201)5.23285351
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23047622
6maturation of SSU-rRNA (GO:0030490)5.22040804
7chaperone-mediated protein transport (GO:0072321)5.21983997
8DNA strand elongation (GO:0022616)5.11639304
9viral transcription (GO:0019083)5.11174620
10regulation of mitochondrial translation (GO:0070129)5.00544649
11translational termination (GO:0006415)4.97363160
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.89441428
13ATP synthesis coupled proton transport (GO:0015986)4.89441428
14DNA replication initiation (GO:0006270)4.80828640
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.80637619
16ribosomal small subunit biogenesis (GO:0042274)4.80474751
17oxidative phosphorylation (GO:0006119)4.61339834
18DNA unwinding involved in DNA replication (GO:0006268)4.58422464
19translational elongation (GO:0006414)4.56204241
20telomere maintenance via recombination (GO:0000722)4.53967856
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40002818
22ribosomal large subunit biogenesis (GO:0042273)4.38617008
23respiratory electron transport chain (GO:0022904)4.35921126
24protein complex biogenesis (GO:0070271)4.31196010
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28641662
26mitotic recombination (GO:0006312)4.27689907
27nucleobase biosynthetic process (GO:0046112)4.27025730
28electron transport chain (GO:0022900)4.26529882
29formation of translation preinitiation complex (GO:0001731)4.25157304
30mitochondrial respiratory chain complex assembly (GO:0033108)4.22020596
31telomere maintenance via telomere lengthening (GO:0010833)4.21161733
32base-excision repair, AP site formation (GO:0006285)4.20423486
33translational initiation (GO:0006413)4.17806712
34cotranslational protein targeting to membrane (GO:0006613)4.17521795
35protein targeting to ER (GO:0045047)4.15562258
36ribonucleoprotein complex biogenesis (GO:0022613)4.13611785
37DNA replication checkpoint (GO:0000076)4.10942738
38pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.10297421
39deoxyribonucleotide catabolic process (GO:0009264)4.07555737
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07269826
41CENP-A containing nucleosome assembly (GO:0034080)4.05717212
42purine nucleobase biosynthetic process (GO:0009113)4.00173470
43pseudouridine synthesis (GO:0001522)3.98804453
44chromatin remodeling at centromere (GO:0031055)3.96093003
45protein targeting to mitochondrion (GO:0006626)3.94299849
46protein localization to kinetochore (GO:0034501)3.93501855
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93337621
48protein localization to endoplasmic reticulum (GO:0070972)3.92922780
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92416441
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.92416441
51NADH dehydrogenase complex assembly (GO:0010257)3.92416441
52pyrimidine nucleotide catabolic process (GO:0006244)3.88416217
53cellular protein complex disassembly (GO:0043624)3.88211027
54nucleotide-excision repair, DNA gap filling (GO:0006297)3.87024140
55deoxyribose phosphate catabolic process (GO:0046386)3.86939137
56ribosome biogenesis (GO:0042254)3.86189838
57viral life cycle (GO:0019058)3.84444182
58protein maturation by protein folding (GO:0022417)3.84438569
59IMP biosynthetic process (GO:0006188)3.81385596
60purine deoxyribonucleotide catabolic process (GO:0009155)3.79980255
61spliceosomal snRNP assembly (GO:0000387)3.75358214
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.71371645
63protoporphyrinogen IX biosynthetic process (GO:0006782)3.71226540
64GTP biosynthetic process (GO:0006183)3.70931720
65rRNA processing (GO:0006364)3.68461971
66kinetochore organization (GO:0051383)3.66477116
67folic acid-containing compound biosynthetic process (GO:0009396)3.66126713
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62723002
69establishment of protein localization to mitochondrion (GO:0072655)3.62463986
70kinetochore assembly (GO:0051382)3.59589206
71pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.58573373
72guanosine-containing compound biosynthetic process (GO:1901070)3.57523358
73rRNA metabolic process (GO:0016072)3.55912594
74DNA replication-independent nucleosome assembly (GO:0006336)3.55160739
75DNA replication-independent nucleosome organization (GO:0034724)3.55160739
76UTP biosynthetic process (GO:0006228)3.55033831
77proteasome assembly (GO:0043248)3.53735259
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.53088420
79mitotic metaphase plate congression (GO:0007080)3.49210604
80protein complex disassembly (GO:0043241)3.47940223
81protein localization to chromosome, centromeric region (GO:0071459)3.45929741
82translation (GO:0006412)3.43774221
83GDP-mannose metabolic process (GO:0019673)3.42198235
84protein localization to mitochondrion (GO:0070585)3.41800387
85peptidyl-histidine modification (GO:0018202)3.41580036
862-deoxyribonucleotide metabolic process (GO:0009394)3.41201120
872-deoxyribonucleotide biosynthetic process (GO:0009265)3.39899608
88deoxyribose phosphate biosynthetic process (GO:0046385)3.39899608
89* deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.39444142
90purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36657570
91purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.36428063
92transcription-coupled nucleotide-excision repair (GO:0006283)3.35466713
93deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.34483070
94establishment of integrated proviral latency (GO:0075713)3.33721242
95IMP metabolic process (GO:0046040)3.31694344
96cytochrome complex assembly (GO:0017004)3.30923033
97macromolecular complex disassembly (GO:0032984)3.30785146
98nuclear-transcribed mRNA catabolic process (GO:0000956)3.29926687
99DNA replication-dependent nucleosome assembly (GO:0006335)3.29093016
100DNA replication-dependent nucleosome organization (GO:0034723)3.29093016
101ribosome assembly (GO:0042255)3.28042354
102transcription elongation from RNA polymerase III promoter (GO:0006385)3.26817631
103termination of RNA polymerase III transcription (GO:0006386)3.26817631
104CTP metabolic process (GO:0046036)3.25538136
105CTP biosynthetic process (GO:0006241)3.25538136
106ATP biosynthetic process (GO:0006754)3.25532171
107nucleobase-containing small molecule interconversion (GO:0015949)3.25191016
108mitotic nuclear envelope disassembly (GO:0007077)3.24887083
109transcription from mitochondrial promoter (GO:0006390)3.24581828
110UTP metabolic process (GO:0046051)3.24493243
111ribonucleoside triphosphate biosynthetic process (GO:0009201)3.22654107
112cellular component biogenesis (GO:0044085)3.22584738
113deoxyribose phosphate metabolic process (GO:0019692)3.21992027
114protoporphyrinogen IX metabolic process (GO:0046501)3.18978836
115rRNA modification (GO:0000154)3.18382751
116heme biosynthetic process (GO:0006783)3.17927994
117exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17769324
118spliceosomal complex assembly (GO:0000245)3.16712381
119pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.16578193
120histone exchange (GO:0043486)3.16273348
121respiratory chain complex IV assembly (GO:0008535)3.15772367
122mRNA catabolic process (GO:0006402)3.14147553
123viral mRNA export from host cell nucleus (GO:0046784)3.13205376
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12729754
125regulation of nuclear cell cycle DNA replication (GO:0033262)3.12173038
126metaphase plate congression (GO:0051310)3.09666734
127RNA catabolic process (GO:0006401)3.08624987
128metallo-sulfur cluster assembly (GO:0031163)3.08198193
129iron-sulfur cluster assembly (GO:0016226)3.08198193
130folic acid metabolic process (GO:0046655)3.08129901
131telomere organization (GO:0032200)3.06102017
132deoxyribonucleotide biosynthetic process (GO:0009263)3.05736026
133telomere maintenance (GO:0000723)3.05377332
134cell cycle G1/S phase transition (GO:0044843)3.04707909
135G1/S transition of mitotic cell cycle (GO:0000082)3.04707909
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04691591
137nucleotide salvage (GO:0043173)3.03642002
138nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01919397
139regulation of cellular amino acid metabolic process (GO:0006521)3.01652905
140regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00887826
141attachment of spindle microtubules to kinetochore (GO:0008608)3.00202925
142nucleoside triphosphate biosynthetic process (GO:0009142)3.00011708
143mitochondrial transport (GO:0006839)2.99784376
144membrane disassembly (GO:0030397)2.97750062
145nuclear envelope disassembly (GO:0051081)2.97750062
146peptidyl-arginine omega-N-methylation (GO:0035247)2.97579880
147pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.96098583
148pentose metabolic process (GO:0019321)2.95703176
149proline biosynthetic process (GO:0006561)2.95662122
150positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94060586
151deoxyribonucleotide metabolic process (GO:0009262)2.93410151
152regulation of double-strand break repair via homologous recombination (GO:0010569)2.92951364
153somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90923609
154somatic hypermutation of immunoglobulin genes (GO:0016446)2.90923609
155negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87272562
156negative regulation of ligase activity (GO:0051352)2.87272562
157pteridine-containing compound biosynthetic process (GO:0042559)2.87047754
158ncRNA processing (GO:0034470)2.84579113
159tRNA methylation (GO:0030488)2.84488729
160maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80508675
161ncRNA metabolic process (GO:0034660)2.79619124
162negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79339162
163pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.79181838
164mismatch repair (GO:0006298)2.78637703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.39489268
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.63773436
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97632315
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40923016
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39939854
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.33058019
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.20581331
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13776103
9MYC_18358816_ChIP-ChIP_MESCs_Mouse3.09392108
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.04272186
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03857380
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99803343
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94610347
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.92753102
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.92107824
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.71692273
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67932140
18XRN2_22483619_ChIP-Seq_HELA_Human2.45602180
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42110962
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42022251
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41062378
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34301383
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30878546
24VDR_23849224_ChIP-Seq_CD4+_Human2.23018774
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18625190
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17686995
27FOXP3_21729870_ChIP-Seq_TREG_Human2.04873906
28DCP1A_22483619_ChIP-Seq_HELA_Human2.04602179
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00090268
30AR_21909140_ChIP-Seq_LNCAP_Human1.94272716
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90990989
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90617828
33GABP_19822575_ChIP-Seq_HepG2_Human1.88396172
34TTF2_22483619_ChIP-Seq_HELA_Human1.87635641
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86961632
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.86371056
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85549681
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79040064
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77345619
40ZNF263_19887448_ChIP-Seq_K562_Human1.76078552
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.72913186
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72666061
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71664692
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69698243
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.67396821
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.59819020
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58420775
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.56547518
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56108994
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55784078
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54078160
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53905482
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50737890
54CIITA_25753668_ChIP-Seq_RAJI_Human1.48572553
55ELK1_19687146_ChIP-ChIP_HELA_Human1.48292108
56CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47466684
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46317858
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42731496
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39306874
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37635072
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32873805
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31126090
63MYC_22102868_ChIP-Seq_BL_Human1.30807274
64KDM5A_27292631_Chip-Seq_BREAST_Human1.29674585
65LXR_22292898_ChIP-Seq_THP-1_Human1.29189651
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28864364
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.28388303
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26686999
69FOXP1_21924763_ChIP-Seq_HESCs_Human1.26598326
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23396904
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.21387577
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21296241
73BCL6_27268052_Chip-Seq_Bcells_Human1.20607396
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19171329
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18227568
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.17552733
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.16683247
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14991783
79P68_20966046_ChIP-Seq_HELA_Human1.14010001
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12548390
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12103432
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.11933975
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10058509
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09965071
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09854409
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08936513
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.08351725
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07805664
89MYC_18940864_ChIP-ChIP_HL60_Human1.07785686
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06700116
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06087818
92VDR_21846776_ChIP-Seq_THP-1_Human1.04532819
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04278648
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04097903
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03495591
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02202401
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99787872
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98989370
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98835948
100SA1_27219007_Chip-Seq_ERYTHROID_Human0.98785224
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98075871
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97736347
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96727192
104BCOR_27268052_Chip-Seq_Bcells_Human0.96661654
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95866238
106TFEB_21752829_ChIP-Seq_HELA_Human0.95462810
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95203784
108CTCF_21964334_Chip-Seq_Bcells_Human0.94649650
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91875429
110E2F1_20622854_ChIP-Seq_HELA_Human0.91222952
111SPI1_23547873_ChIP-Seq_NB4_Human0.88515297
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.87933254
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85867815
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85865475
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83552780
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83272347
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82478468
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81671758
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81616497
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81233502
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79679989
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78469091
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76428040
124CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75759668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.36802979
2MP0010094_abnormal_chromosome_stability4.71061750
3MP0003111_abnormal_nucleus_morphology4.46128035
4MP0004957_abnormal_blastocyst_morpholog4.45492721
5MP0008057_abnormal_DNA_replication4.05267395
6MP0003077_abnormal_cell_cycle3.92004885
7MP0008058_abnormal_DNA_repair3.71854091
8MP0005083_abnormal_biliary_tract3.33919357
9MP0008007_abnormal_cellular_replicative3.04505689
10MP0002396_abnormal_hematopoietic_system3.04446933
11MP0008932_abnormal_embryonic_tissue2.59858510
12MP0005451_abnormal_body_composition2.56976963
13MP0000678_abnormal_parathyroid_gland2.53541122
14MP0005670_abnormal_white_adipose2.26983854
15MP0003806_abnormal_nucleotide_metabolis2.25170440
16MP0009379_abnormal_foot_pigmentation2.20064827
17MP0000490_abnormal_crypts_of2.13930849
18MP0008875_abnormal_xenobiotic_pharmacok2.03923725
19MP0001730_embryonic_growth_arrest2.01329485
20MP0002234_abnormal_pharynx_morphology2.00290340
21MP0010352_gastrointestinal_tract_polyps2.00019912
22MP0000350_abnormal_cell_proliferation1.99199690
23MP0003786_premature_aging1.98690806
24MP0002139_abnormal_hepatobiliary_system1.92819419
25MP0003186_abnormal_redox_activity1.92531672
26MP0003123_paternal_imprinting1.91741543
27MP0010030_abnormal_orbit_morphology1.91100362
28MP0005365_abnormal_bile_salt1.88680699
29MP0005332_abnormal_amino_acid1.67663373
30MP0005397_hematopoietic_system_phenotyp1.62123885
31MP0001545_abnormal_hematopoietic_system1.62123885
32MP0005360_urolithiasis1.62008376
33MP0003718_maternal_effect1.59012425
34MP0004808_abnormal_hematopoietic_stem1.57124106
35MP0005058_abnormal_lysosome_morphology1.55760265
36MP0000313_abnormal_cell_death1.53589643
37MP0002132_abnormal_respiratory_system1.49513918
38MP0005408_hypopigmentation1.49022819
39MP0002163_abnormal_gland_morphology1.47903518
40MP0001697_abnormal_embryo_size1.47166836
41MP0002019_abnormal_tumor_incidence1.46917501
42MP0001293_anophthalmia1.41826369
43MP0002080_prenatal_lethality1.41426654
44MP0006292_abnormal_olfactory_placode1.39577971
45MP0002877_abnormal_melanocyte_morpholog1.38525353
46MP0005380_embryogenesis_phenotype1.38440316
47MP0001672_abnormal_embryogenesis/_devel1.38440316
48MP0008877_abnormal_DNA_methylation1.38315995
49MP0001853_heart_inflammation1.33366500
50MP0005085_abnormal_gallbladder_physiolo1.33363206
51MP0005075_abnormal_melanosome_morpholog1.33285037
52MP0000566_synostosis1.32509390
53MP0002085_abnormal_embryonic_tissue1.24696146
54MP0009333_abnormal_splenocyte_physiolog1.23191874
55MP0003315_abnormal_perineum_morphology1.21118287
56MP0001661_extended_life_span1.19550355
57MP0010307_abnormal_tumor_latency1.18862460
58MP0001873_stomach_inflammation1.18806778
59MP0003984_embryonic_growth_retardation1.17798169
60MP0001346_abnormal_lacrimal_gland1.17628399
61MP0006036_abnormal_mitochondrial_physio1.16958157
62MP0002088_abnormal_embryonic_growth/wei1.15042649
63MP0004133_heterotaxia1.14839144
64MP0003567_abnormal_fetal_cardiomyocyte1.14756661
65MP0000681_abnormal_thyroid_gland1.13075486
66MP0002210_abnormal_sex_determination1.12531120
67MP0003763_abnormal_thymus_physiology1.10098298
68MP0002086_abnormal_extraembryonic_tissu1.08054380
69MP0002084_abnormal_developmental_patter1.07210423
70MP0005174_abnormal_tail_pigmentation1.07067538
71MP0005330_cardiomyopathy1.06702758
72MP0005636_abnormal_mineral_homeostasis1.06562592
73MP0009643_abnormal_urine_homeostasis1.05316399
74MP0004197_abnormal_fetal_growth/weight/1.02993386
75MP0003941_abnormal_skin_development1.00969981
76MP0001145_abnormal_male_reproductive1.00905887
77MP0000358_abnormal_cell_content/0.96433762
78MP0000703_abnormal_thymus_morphology0.96392985
79MP0002160_abnormal_reproductive_system0.95763718
80MP0006035_abnormal_mitochondrial_morpho0.95457193
81MP0002722_abnormal_immune_system0.95237404
82MP0000689_abnormal_spleen_morphology0.94423657
83MP0002398_abnormal_bone_marrow0.94360686
84MP0009697_abnormal_copulation0.94050539
85MP0004147_increased_porphyrin_level0.92368048
86MP0009840_abnormal_foam_cell0.92274456
87MP0002277_abnormal_respiratory_mucosa0.92228937
88MP0002095_abnormal_skin_pigmentation0.92202738
89MP0004019_abnormal_vitamin_homeostasis0.91822277
90MP0002653_abnormal_ependyma_morphology0.89373308
91MP0001881_abnormal_mammary_gland0.88552169
92MP0000653_abnormal_sex_gland0.88065515
93MP0001727_abnormal_embryo_implantation0.87931681
94MP0001905_abnormal_dopamine_level0.86468987
95MP0000015_abnormal_ear_pigmentation0.86217010
96MP0000858_altered_metastatic_potential0.85241974
97MP0005379_endocrine/exocrine_gland_phen0.84864395
98MP0001119_abnormal_female_reproductive0.84549082
99MP0001764_abnormal_homeostasis0.83648370
100MP0005319_abnormal_enzyme/_coenzyme0.82156159
101MP0002822_catalepsy0.81504312
102MP0000343_altered_response_to0.81406554
103MP0002429_abnormal_blood_cell0.80828273
104MP0002148_abnormal_hypersensitivity_rea0.80685560
105MP0006054_spinal_hemorrhage0.80405553
106MP0001929_abnormal_gametogenesis0.80354907
107MP0002249_abnormal_larynx_morphology0.79450418
108MP0002938_white_spotting0.78731276
109MP0004858_abnormal_nervous_system0.78444220
110MP0009278_abnormal_bone_marrow0.78197740
111MP0002111_abnormal_tail_morphology0.78091901
112MP0005389_reproductive_system_phenotype0.77564793
113MP0000049_abnormal_middle_ear0.76450734
114MP0009053_abnormal_anal_canal0.74816816
115MP0005584_abnormal_enzyme/coenzyme_acti0.74681534
116MP0003075_altered_response_to0.72719368
117MP0005266_abnormal_metabolism0.71443949
118MP0003656_abnormal_erythrocyte_physiolo0.71218650
119MP0003136_yellow_coat_color0.70273547
120MP0003890_abnormal_embryonic-extraembry0.69663958
121MP0008873_increased_physiological_sensi0.69047185
122MP0002075_abnormal_coat/hair_pigmentati0.67308129
123MP0004381_abnormal_hair_follicle0.67018154
124MP0000477_abnormal_intestine_morphology0.66454529
125MP0003119_abnormal_digestive_system0.65844096
126MP0002837_dystrophic_cardiac_calcinosis0.65345342
127MP0000003_abnormal_adipose_tissue0.64906081
128MP0000516_abnormal_urinary_system0.64680667
129MP0005367_renal/urinary_system_phenotyp0.64680667
130MP0005501_abnormal_skin_physiology0.64562260
131MP0005384_cellular_phenotype0.64353187
132MP0003252_abnormal_bile_duct0.62534467
133MP0002796_impaired_skin_barrier0.62509458
134MP0005025_abnormal_response_to0.61918144
135MP0000598_abnormal_liver_morphology0.61034507
136MP0000465_gastrointestinal_hemorrhage0.60704440
137MP0004043_abnormal_pH_regulation0.59645298
138MP0002092_abnormal_eye_morphology0.59432770
139MP0008469_abnormal_protein_level0.59321453
140MP0000716_abnormal_immune_system0.59032361
141MP0005084_abnormal_gallbladder_morpholo0.58563683
142MP0000609_abnormal_liver_physiology0.58499705
143MP0000372_irregular_coat_pigmentation0.58013497
144MP0002102_abnormal_ear_morphology0.57892841
145MP0002751_abnormal_autonomic_nervous0.55665396
146MP0001186_pigmentation_phenotype0.53671882
147MP0001919_abnormal_reproductive_system0.53288580
148MP0009672_abnormal_birth_weight0.52692321
149MP0005621_abnormal_cell_physiology0.52611085
150MP0005023_abnormal_wound_healing0.52382463
151MP0000371_diluted_coat_color0.51082688

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.93959509
2Abnormality of cells of the erythroid lineage (HP:0012130)5.74912297
3Abnormal mitochondria in muscle tissue (HP:0008316)5.56989380
4Abnormal number of erythroid precursors (HP:0012131)5.56525131
5Acute necrotizing encephalopathy (HP:0006965)5.25123702
6Acute encephalopathy (HP:0006846)4.84622449
7Birth length less than 3rd percentile (HP:0003561)4.71823375
8Increased intramyocellular lipid droplets (HP:0012240)4.63538094
9Oral leukoplakia (HP:0002745)4.40225749
10Aplastic anemia (HP:0001915)4.28762502
11Increased muscle lipid content (HP:0009058)4.27439832
12Progressive macrocephaly (HP:0004481)4.08629087
13Cerebral edema (HP:0002181)4.01146251
14Colon cancer (HP:0003003)3.91308781
15Macrocytic anemia (HP:0001972)3.89123882
16Pallor (HP:0000980)3.83261672
17Renal Fanconi syndrome (HP:0001994)3.71194902
18Lactic acidosis (HP:0003128)3.69344027
19Rough bone trabeculation (HP:0100670)3.54481837
20Breast hypoplasia (HP:0003187)3.50960439
21Chromsome breakage (HP:0040012)3.49841995
22Selective tooth agenesis (HP:0001592)3.48265147
23Exercise intolerance (HP:0003546)3.44244803
24Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32494262
25Ragged-red muscle fibers (HP:0003200)3.30469978
26Respiratory failure (HP:0002878)3.20134387
2711 pairs of ribs (HP:0000878)3.07478999
28Premature graying of hair (HP:0002216)3.01221406
29Abnormality of the preputium (HP:0100587)2.99979528
30Absent thumb (HP:0009777)2.95270277
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93463559
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93463559
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89300733
34Microretrognathia (HP:0000308)2.87349701
35Patellar aplasia (HP:0006443)2.87078627
36Carpal bone hypoplasia (HP:0001498)2.80530484
37Pancytopenia (HP:0001876)2.75774361
38Abnormality of the anterior horn cell (HP:0006802)2.74835130
39Degeneration of anterior horn cells (HP:0002398)2.74835130
40Congenital malformation of the right heart (HP:0011723)2.71172020
41Double outlet right ventricle (HP:0001719)2.71172020
42Aplasia/Hypoplasia of the patella (HP:0006498)2.70268390
43Abnormality of chromosome stability (HP:0003220)2.69746232
44Meckel diverticulum (HP:0002245)2.68937333
45Abnormality of glycolysis (HP:0004366)2.66641733
46Abnormal protein glycosylation (HP:0012346)2.65203090
47Abnormal glycosylation (HP:0012345)2.65203090
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.65203090
49Abnormal protein N-linked glycosylation (HP:0012347)2.65203090
50Dicarboxylic aciduria (HP:0003215)2.64037685
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64037685
52Myelodysplasia (HP:0002863)2.62306101
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61954028
54Abnormality of the ileum (HP:0001549)2.61672389
55Lethargy (HP:0001254)2.60345503
56Bone marrow hypocellularity (HP:0005528)2.60286000
57Increased serum pyruvate (HP:0003542)2.59208322
58Thrombocytosis (HP:0001894)2.57603757
59Cerebral hypomyelination (HP:0006808)2.55932399
60Abnormality of pyrimidine metabolism (HP:0004353)2.54902129
61Reduced antithrombin III activity (HP:0001976)2.53664053
62Abnormal trabecular bone morphology (HP:0100671)2.51549173
63Abnormal number of incisors (HP:0011064)2.50721394
64Medulloblastoma (HP:0002885)2.48802292
65Microvesicular hepatic steatosis (HP:0001414)2.47725788
66Testicular atrophy (HP:0000029)2.46371484
67Type I transferrin isoform profile (HP:0003642)2.46044596
68Increased serum lactate (HP:0002151)2.45043060
69Cellular immunodeficiency (HP:0005374)2.43982242
70Neoplasm of the pancreas (HP:0002894)2.42096925
71Abnormality of reticulocytes (HP:0004312)2.41889225
72Progressive microcephaly (HP:0000253)2.39282663
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.38520270
74Agnosia (HP:0010524)2.37836485
75Duplicated collecting system (HP:0000081)2.36134609
76Absent radius (HP:0003974)2.35862546
77Abnormality of the heme biosynthetic pathway (HP:0010472)2.35760042
78Emotional lability (HP:0000712)2.32634638
79CNS demyelination (HP:0007305)2.31536658
803-Methylglutaconic aciduria (HP:0003535)2.31450203
81Horseshoe kidney (HP:0000085)2.28421292
82Opisthotonus (HP:0002179)2.28130362
83Truncus arteriosus (HP:0001660)2.27098785
84Leukodystrophy (HP:0002415)2.26627014
85Trismus (HP:0000211)2.26105964
86Hypertensive crisis (HP:0100735)2.23137249
87Small intestinal stenosis (HP:0012848)2.22704107
88Duodenal stenosis (HP:0100867)2.22704107
89Hyperthyroidism (HP:0000836)2.22533522
90Triphalangeal thumb (HP:0001199)2.21278429
91Ependymoma (HP:0002888)2.19835892
92Generalized aminoaciduria (HP:0002909)2.19513420
93Sparse eyelashes (HP:0000653)2.19055709
94Asplenia (HP:0001746)2.18264570
95Aplasia involving forearm bones (HP:0009822)2.17034798
96Absent forearm bone (HP:0003953)2.17034798
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15202521
98Muscle fiber atrophy (HP:0100295)2.14575710
99Tracheoesophageal fistula (HP:0002575)2.13680663
100Hepatic necrosis (HP:0002605)2.13628747
101Abnormality of the renal collecting system (HP:0004742)2.12729166
102Squamous cell carcinoma (HP:0002860)2.11866622
103Chronic obstructive pulmonary disease (HP:0006510)2.11024139
104Obstructive lung disease (HP:0006536)2.11024139
105Gout (HP:0001997)2.10768853
106Megaloblastic anemia (HP:0001889)2.10154707
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09377590
108Sloping forehead (HP:0000340)2.08044415
109Hyperammonemia (HP:0001987)2.07498221
110Hepatocellular necrosis (HP:0001404)2.05299125
111Hyperglycinemia (HP:0002154)2.04521659
112Premature ovarian failure (HP:0008209)2.04482553
113Increased hepatocellular lipid droplets (HP:0006565)2.04339375
114Increased CSF lactate (HP:0002490)2.04109681
115Multiple enchondromatosis (HP:0005701)2.03411674
116Progressive muscle weakness (HP:0003323)2.03302123
117Prolonged neonatal jaundice (HP:0006579)1.99927371
118Type 2 muscle fiber atrophy (HP:0003554)1.99593162
119Aplasia/Hypoplasia of the spleen (HP:0010451)1.99189523
120Abnormality of urine glucose concentration (HP:0011016)1.98984894
121Glycosuria (HP:0003076)1.98984894
122Poikiloderma (HP:0001029)1.97077596
123Hypoplasia of the radius (HP:0002984)1.96150163
124Rhabdomyosarcoma (HP:0002859)1.95370555
125Abnormality of DNA repair (HP:0003254)1.95222393
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.94839212
127Basal cell carcinoma (HP:0002671)1.94484267
128Impulsivity (HP:0100710)1.94277100
129Vomiting (HP:0002013)1.94001341
130Poor head control (HP:0002421)1.93810903
131Abnormality of the duodenum (HP:0002246)1.93574767
132Supernumerary spleens (HP:0009799)1.93298488
133Abnormal lung lobation (HP:0002101)1.92936728
134Mitochondrial inheritance (HP:0001427)1.90445470
135Missing ribs (HP:0000921)1.90059311
136Seborrheic dermatitis (HP:0001051)1.89610595
137Cleft eyelid (HP:0000625)1.89448182
138Cholecystitis (HP:0001082)1.89255227
139Abnormal gallbladder physiology (HP:0012438)1.89255227
140Hypoplastic left heart (HP:0004383)1.89060186
141Abnormality of renal resorption (HP:0011038)1.89049570
142Optic disc pallor (HP:0000543)1.86613105
143Broad distal phalanx of finger (HP:0009836)1.86431578
144Exertional dyspnea (HP:0002875)1.86205539
145Hyperphosphaturia (HP:0003109)1.85170813
146Lymphoma (HP:0002665)1.84608297
147Atresia of the external auditory canal (HP:0000413)1.84523696
148Abnormality of T cell physiology (HP:0011840)1.83677511
149Facial cleft (HP:0002006)1.82458897
150Lipid accumulation in hepatocytes (HP:0006561)1.82380371
151Abnormal umbilical cord blood vessels (HP:0011403)1.82312440
152Single umbilical artery (HP:0001195)1.82312440
153Abnormality of the fetal cardiovascular system (HP:0010948)1.82312440
154Cerebral palsy (HP:0100021)1.82236770
155Abnormality of alanine metabolism (HP:0010916)1.81335115
156Hyperalaninemia (HP:0003348)1.81335115
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81335115
158Optic nerve coloboma (HP:0000588)1.78907966
159Rhabdomyolysis (HP:0003201)1.77967319
160Duplication of thumb phalanx (HP:0009942)1.77391669
161Redundant skin (HP:0001582)1.77132044
162Respiratory difficulties (HP:0002880)1.77098111
163Esophageal neoplasm (HP:0100751)1.76388504
164Neoplasm of head and neck (HP:0012288)1.76388504
165Methylmalonic aciduria (HP:0012120)1.72636709
166Sclerocornea (HP:0000647)1.67932357
167Nausea (HP:0002018)1.67087977
168Gliosis (HP:0002171)1.66971148
169Abnormality of serum amino acid levels (HP:0003112)1.66219077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.66317592
2BUB15.15468162
3WEE14.43086865
4CDC73.76732348
5SMG13.51008899
6STK163.20128860
7NME23.07139466
8EIF2AK12.83278549
9SRPK12.49575035
10TAF12.42494743
11NEK22.40575493
12VRK12.35637690
13ARAF2.25334018
14TTK2.11720480
15BRSK22.10617026
16DYRK32.04925371
17CDK71.94828406
18TLK11.92779352
19NEK11.88035361
20PLK11.84886903
21PLK41.84587875
22TSSK61.82199244
23BCKDK1.81422420
24ACVR1B1.74153510
25RPS6KB21.73474641
26RPS6KA41.73316851
27EIF2AK31.71866493
28ATR1.71597783
29CCNB11.71442979
30MKNK11.70401128
31AURKB1.60710008
32NUAK11.56411864
33ERN11.53819187
34PASK1.52484526
35TESK21.49864367
36PIM21.48359620
37CSNK1G31.41711635
38BRSK11.39815880
39EEF2K1.39740889
40CDK191.33411008
41PDK21.30539842
42CHEK21.28560425
43AURKA1.25082957
44CDK81.24195945
45PAK41.22032137
46CDK41.17872542
47PLK31.16858345
48SCYL21.14763089
49MAP3K81.12421903
50CSNK1A1L1.11637108
51MAPKAPK51.11369433
52CAMKK21.10352723
53MKNK21.09886584
54EPHA21.08336337
55LIMK11.06412909
56ZAK1.05169188
57MAPKAPK31.00388451
58TGFBR10.98229773
59FLT30.97353552
60CSNK1G10.96113212
61STK40.94975429
62CHEK10.91265752
63PIM10.91087128
64MAP3K110.85683722
65CSNK1G20.85223798
66KDR0.84006870
67DAPK30.81989884
68EIF2AK20.77730528
69CAMK1D0.76958385
70CSNK2A20.76659910
71CSNK2A10.76029510
72LRRK20.74744138
73PRKD30.69597611
74IRAK30.68962548
75MST40.68714515
76CDK20.68100194
77MAP4K10.67618734
78ATM0.66348795
79NME10.65962188
80MAP2K30.63899057
81STK100.62963792
82CDK90.62711413
83TXK0.60088063
84GRK50.60082429
85TEC0.60039574
86DAPK10.58399906
87TBK10.57501918
88IRAK40.55287703
89YES10.55231738
90BTK0.54557499
91CDK60.52068381
92PAK10.50557876
93BRAF0.49500068
94BRD40.47864024
95MAP4K20.47655989
96CDK10.47163573
97KIT0.45847922
98MAP3K100.45521016
99PBK0.44149837
100RPS6KA50.43758742
101ABL20.42205726
102PRKCI0.39776575
103DYRK20.38319231
104CAMK1G0.38069289
105CSF1R0.36852443
106CDK120.36543178
107TRIB30.36488554
108ILK0.35016914
109AKT20.34169300
110TESK10.32958823
111CAMK2G0.32526487
112MAP2K60.32414013
113IRAK20.30415706
114CDK11A0.30381671
115TAOK20.30305365
116MELK0.29954188
117RAF10.29650083
118MAP3K30.28830572
119MATK0.28224852
120MUSK0.27444924
121RPS6KC10.26915055
122RPS6KL10.26915055
123RPS6KA60.26496562
124CDK150.24784959
125IKBKB0.24783348
126LYN0.24672854
127MAPK110.24419721
128TYK20.23847288
129MAP2K70.23666515
130CDK140.22343070
131RPS6KB10.20675991
132CSNK1E0.20345002
133CDK180.19679746
134CSNK1A10.19281553
135PRKDC0.19176671
136MAP2K20.18104187
137MAP3K10.17653305

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.35821589
2Ribosome_Homo sapiens_hsa030104.51173599
3Mismatch repair_Homo sapiens_hsa034304.34564568
4RNA polymerase_Homo sapiens_hsa030203.32631374
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30671378
6Base excision repair_Homo sapiens_hsa034103.28365301
7Proteasome_Homo sapiens_hsa030503.27179284
8Spliceosome_Homo sapiens_hsa030403.17025025
9Homologous recombination_Homo sapiens_hsa034403.02707748
10Nucleotide excision repair_Homo sapiens_hsa034202.85701222
11Pyrimidine metabolism_Homo sapiens_hsa002402.81474128
12One carbon pool by folate_Homo sapiens_hsa006702.77172246
13RNA transport_Homo sapiens_hsa030132.61510025
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41096344
15Cell cycle_Homo sapiens_hsa041102.25010966
16Fanconi anemia pathway_Homo sapiens_hsa034602.16037110
17Non-homologous end-joining_Homo sapiens_hsa034501.95499385
18RNA degradation_Homo sapiens_hsa030181.79592992
19Fatty acid elongation_Homo sapiens_hsa000621.63775102
20Basal transcription factors_Homo sapiens_hsa030221.57647718
21Sulfur metabolism_Homo sapiens_hsa009201.52742046
22Folate biosynthesis_Homo sapiens_hsa007901.49020083
23Purine metabolism_Homo sapiens_hsa002301.46281126
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43273322
25p53 signaling pathway_Homo sapiens_hsa041151.36453220
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.15801830
27mRNA surveillance pathway_Homo sapiens_hsa030151.15762218
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.14803935
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06838354
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.05788542
31Sulfur relay system_Homo sapiens_hsa041221.01679829
32Systemic lupus erythematosus_Homo sapiens_hsa053221.00661362
33Selenocompound metabolism_Homo sapiens_hsa004501.00401706
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00113119
35Biosynthesis of amino acids_Homo sapiens_hsa012300.99189575
36Cardiac muscle contraction_Homo sapiens_hsa042600.96957155
37Protein export_Homo sapiens_hsa030600.96617053
38Pentose phosphate pathway_Homo sapiens_hsa000300.93851415
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90833072
40Epstein-Barr virus infection_Homo sapiens_hsa051690.88650536
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88310172
42Glutathione metabolism_Homo sapiens_hsa004800.85900082
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85705536
44Huntingtons disease_Homo sapiens_hsa050160.85427542
45Parkinsons disease_Homo sapiens_hsa050120.81965045
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81906861
47Herpes simplex infection_Homo sapiens_hsa051680.73588931
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71960250
49Fructose and mannose metabolism_Homo sapiens_hsa000510.65935792
50Fatty acid degradation_Homo sapiens_hsa000710.65356519
51Oxidative phosphorylation_Homo sapiens_hsa001900.64004286
52Carbon metabolism_Homo sapiens_hsa012000.61312228
53Arginine biosynthesis_Homo sapiens_hsa002200.61269037
54Propanoate metabolism_Homo sapiens_hsa006400.59008523
55Antigen processing and presentation_Homo sapiens_hsa046120.57253769
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55418202
57N-Glycan biosynthesis_Homo sapiens_hsa005100.55335239
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53999579
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53898105
60Viral carcinogenesis_Homo sapiens_hsa052030.53013569
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.50053791
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49947054
63Other glycan degradation_Homo sapiens_hsa005110.48874417
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48827519
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47093139
66Metabolic pathways_Homo sapiens_hsa011000.46777628
67Oocyte meiosis_Homo sapiens_hsa041140.46427530
68Legionellosis_Homo sapiens_hsa051340.46280828
69Tryptophan metabolism_Homo sapiens_hsa003800.45847356
70Fatty acid metabolism_Homo sapiens_hsa012120.45248528
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43854736
72HTLV-I infection_Homo sapiens_hsa051660.43316119
73Vitamin B6 metabolism_Homo sapiens_hsa007500.43022207
74Galactose metabolism_Homo sapiens_hsa000520.41856490
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39229624
76Vibrio cholerae infection_Homo sapiens_hsa051100.38502784
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37870937
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36353663
79Arginine and proline metabolism_Homo sapiens_hsa003300.35014903
80Small cell lung cancer_Homo sapiens_hsa052220.34945826
81Thyroid cancer_Homo sapiens_hsa052160.34875979
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34558388
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34480719
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.34421585
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33704491
86Fat digestion and absorption_Homo sapiens_hsa049750.29800862
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28681145
88Butanoate metabolism_Homo sapiens_hsa006500.28570845
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28385472
90Caffeine metabolism_Homo sapiens_hsa002320.28335744
91Asthma_Homo sapiens_hsa053100.27844238
92Apoptosis_Homo sapiens_hsa042100.27226433
93Lysosome_Homo sapiens_hsa041420.26970204
94Collecting duct acid secretion_Homo sapiens_hsa049660.26312784
95Arachidonic acid metabolism_Homo sapiens_hsa005900.25873671
96Alzheimers disease_Homo sapiens_hsa050100.23898425
97Bladder cancer_Homo sapiens_hsa052190.23761140
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22728048
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21942845
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20910132
101Primary immunodeficiency_Homo sapiens_hsa053400.20165682
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18903330
103MicroRNAs in cancer_Homo sapiens_hsa052060.18479946
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.16675670
105Basal cell carcinoma_Homo sapiens_hsa052170.16240866
106Measles_Homo sapiens_hsa051620.16176105
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16103615
108Hepatitis B_Homo sapiens_hsa051610.15518225
109Notch signaling pathway_Homo sapiens_hsa043300.14918786
110Alcoholism_Homo sapiens_hsa050340.14680993
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14534843
112Renin-angiotensin system_Homo sapiens_hsa046140.12272081
113beta-Alanine metabolism_Homo sapiens_hsa004100.11992512
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11679197
115Phenylalanine metabolism_Homo sapiens_hsa003600.11598902
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11571502
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11280998
118Pyruvate metabolism_Homo sapiens_hsa006200.09434504
119Peroxisome_Homo sapiens_hsa041460.08480472
120Retinol metabolism_Homo sapiens_hsa008300.08018946
121Vitamin digestion and absorption_Homo sapiens_hsa049770.07372919
122Chemical carcinogenesis_Homo sapiens_hsa052040.07047002
123Tyrosine metabolism_Homo sapiens_hsa003500.05943519
124Shigellosis_Homo sapiens_hsa051310.05646396
125Hematopoietic cell lineage_Homo sapiens_hsa046400.05412865
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05340645
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.05206181

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