DNTT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ethanol (GO:0071361)9.12604257
2response to hydroperoxide (GO:0033194)7.98804162
3regulation of gamma-delta T cell differentiation (GO:0045586)6.71064145
4positive regulation of gamma-delta T cell activation (GO:0046645)6.66352604
5negative regulation of thymocyte apoptotic process (GO:0070244)6.53180599
6resolution of meiotic recombination intermediates (GO:0000712)6.43915361
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.28442618
8cellular hyperosmotic response (GO:0071474)6.12654848
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.11249664
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.11249664
11regulation of gamma-delta T cell activation (GO:0046643)5.91542201
12ribosomal small subunit assembly (GO:0000028)5.81673335
13somatic cell DNA recombination (GO:0016444)5.80346455
14somatic diversification of immune receptors via germline recombination within a single locus (GO:0005.80346455
15purine nucleotide salvage (GO:0032261)5.68255171
16histone monoubiquitination (GO:0010390)5.61711002
17B cell differentiation (GO:0030183)5.57496237
18DNA unwinding involved in DNA replication (GO:0006268)5.41000693
19somatic diversification of immune receptors (GO:0002200)5.39377063
20positive T cell selection (GO:0043368)5.18512194
21mucosal-associated lymphoid tissue development (GO:0048537)5.01815024
22Peyers patch development (GO:0048541)5.01815024
23establishment of integrated proviral latency (GO:0075713)4.99049494
24antigen processing and presentation of endogenous antigen (GO:0019883)4.95815602
25antigen processing and presentation via MHC class Ib (GO:0002475)4.94662140
26negative regulation of B cell apoptotic process (GO:0002903)4.86114638
27regulation of T cell apoptotic process (GO:0070232)4.84418540
28purine ribonucleotide transport (GO:0015868)4.82258075
29B cell proliferation (GO:0042100)4.64531678
30T cell differentiation in thymus (GO:0033077)4.61737900
31positive regulation of B cell differentiation (GO:0045579)4.59377132
32negative T cell selection (GO:0043383)4.53116013
33adenine nucleotide transport (GO:0051503)4.50611031
34DNA ligation (GO:0006266)4.42554981
35viral transcription (GO:0019083)4.42483883
36mast cell activation (GO:0045576)4.40846923
37interleukin-6-mediated signaling pathway (GO:0070102)4.37524238
38translational termination (GO:0006415)4.18799757
39T cell homeostasis (GO:0043029)4.17359210
40adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.13882959
41regulation of thymocyte apoptotic process (GO:0070243)4.11626637
42mast cell activation involved in immune response (GO:0002279)4.10868002
43mast cell degranulation (GO:0043303)4.10868002
44nucleotide salvage (GO:0043173)4.09362883
45negative regulation of leukocyte apoptotic process (GO:2000107)4.02363509
46regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.01949013
47regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.01949013
48T cell selection (GO:0045058)4.00431083
49establishment of viral latency (GO:0019043)3.99557410
50negative regulation of sodium ion transport (GO:0010766)3.99109461
51histone ubiquitination (GO:0016574)3.98978410
52T cell differentiation (GO:0030217)3.97606101
53T cell receptor signaling pathway (GO:0050852)3.97458269
54B cell activation (GO:0042113)3.95980779
55heparin metabolic process (GO:0030202)3.95856110
56heparin biosynthetic process (GO:0030210)3.95856110
57negative regulation of cell aging (GO:0090344)3.95632401
58regulation of dendritic cell antigen processing and presentation (GO:0002604)3.88939793
59negative regulation of T cell apoptotic process (GO:0070233)3.87886244
60regulation of T cell receptor signaling pathway (GO:0050856)3.87787458
61DNA strand elongation involved in DNA replication (GO:0006271)3.87442176
62regulation of B cell differentiation (GO:0045577)3.82908072
63regulation of chromatin silencing (GO:0031935)3.81184529
64purine-containing compound salvage (GO:0043101)3.79841539
65DNA strand elongation (GO:0022616)3.79460704
66positive regulation of histone H3-K4 methylation (GO:0051571)3.72417091
67activated T cell proliferation (GO:0050798)3.71311789
68antigen receptor-mediated signaling pathway (GO:0050851)3.70854184
69regulation of lymphocyte apoptotic process (GO:0070228)3.70034265
70translational elongation (GO:0006414)3.67533666
71positive regulation of granulocyte differentiation (GO:0030854)3.67062797
72regulation of histone H3-K9 methylation (GO:0051570)3.67035930
73labyrinthine layer development (GO:0060711)3.66395776
74positive thymic T cell selection (GO:0045059)3.66045809
75T cell lineage commitment (GO:0002360)3.64869876
76purine deoxyribonucleotide catabolic process (GO:0009155)3.63246606
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61803932
78purine nucleotide transport (GO:0015865)3.61408995
79response to vitamin E (GO:0033197)3.57572668
80negative regulation of T-helper cell differentiation (GO:0045623)3.56249879
81negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.56249879
82regulation of germinal center formation (GO:0002634)3.55838608
83regulation of circadian sleep/wake cycle (GO:0042749)3.53816375
84regulation of circadian sleep/wake cycle, sleep (GO:0045187)3.53816375
85positive regulation by host of viral transcription (GO:0043923)3.52023502
86regulation of translation in response to stress (GO:0043555)3.51013876
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50338158
88nucleosome disassembly (GO:0006337)3.49562025
89protein-DNA complex disassembly (GO:0032986)3.49562025
90mitotic chromosome condensation (GO:0007076)3.48660832
91regulation of response to tumor cell (GO:0002834)3.47414575
92positive regulation of response to tumor cell (GO:0002836)3.47414575
93positive regulation of immune response to tumor cell (GO:0002839)3.47414575
94regulation of immune response to tumor cell (GO:0002837)3.47414575
95dosage compensation (GO:0007549)3.47312915
96telomere maintenance via semi-conservative replication (GO:0032201)3.44435107
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43260092
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40735647
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.38046118
100ribosomal small subunit biogenesis (GO:0042274)3.37678545
101hepatocyte differentiation (GO:0070365)3.37402477
102lipopolysaccharide biosynthetic process (GO:0009103)3.36750875
103cotranslational protein targeting to membrane (GO:0006613)3.35538539
104genitalia morphogenesis (GO:0035112)3.34311368
105protein targeting to ER (GO:0045047)3.33626282
106immunoglobulin mediated immune response (GO:0016064)3.33329728
107regulation of antigen processing and presentation (GO:0002577)3.32623187
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31570322
109regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.31367910
110regulation of T cell mediated cytotoxicity (GO:0001914)3.30664869
111lymphocyte homeostasis (GO:0002260)3.30625423
112poly(A)+ mRNA export from nucleus (GO:0016973)3.28809680
113leukocyte homeostasis (GO:0001776)3.26855633
114cellular protein complex disassembly (GO:0043624)3.26828600
115B cell receptor signaling pathway (GO:0050853)3.26029871
116protein complex disassembly (GO:0043241)3.23943349
117translesion synthesis (GO:0019985)3.23102883
118replicative senescence (GO:0090399)3.22340618
119lymphoid progenitor cell differentiation (GO:0002320)3.21057424
120regulation of B cell apoptotic process (GO:0002902)3.20913472
121positive regulation of antigen processing and presentation (GO:0002579)3.19998707
122alpha-beta T cell differentiation (GO:0046632)3.19992343
123establishment of protein localization to endoplasmic reticulum (GO:0072599)3.17723992
124DNA topological change (GO:0006265)3.17373680
125positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17124440
126viral life cycle (GO:0019058)3.17023421
127positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16780538
128DNA replication initiation (GO:0006270)3.16767097
129response to histamine (GO:0034776)3.15029561
130G-protein coupled receptor internalization (GO:0002031)3.14830197
131negative regulation of erythrocyte differentiation (GO:0045647)3.14460589
132negative regulation of RNA splicing (GO:0033119)3.12332299
133cellular response to interleukin-4 (GO:0071353)3.11215653
134alpha-beta T cell activation (GO:0046631)3.10390865
135chaperone mediated protein folding requiring cofactor (GO:0051085)3.10298078
136thymus development (GO:0048538)3.10164408
137protein localization to endoplasmic reticulum (GO:0070972)3.09793396
138interferon-gamma production (GO:0032609)3.09146932
139maturation of SSU-rRNA (GO:0030490)3.08719586
140regulation of proton transport (GO:0010155)3.07833374
141musculoskeletal movement (GO:0050881)3.07487922
142multicellular organismal movement (GO:0050879)3.07487922
143positive regulation of organ growth (GO:0046622)3.06106963
144positive regulation of renal sodium excretion (GO:0035815)3.04436400
145natural killer cell differentiation (GO:0001779)3.02623256
146regulation of T-helper 1 cell differentiation (GO:0045625)3.02424833
147ether lipid metabolic process (GO:0046485)3.02177027
148prepulse inhibition (GO:0060134)3.01862553
149mitotic sister chromatid cohesion (GO:0007064)3.00957178
150negative regulation of gene expression, epigenetic (GO:0045814)3.00535974
151mitotic recombination (GO:0006312)3.00118372
152lymphocyte differentiation (GO:0030098)2.98994176
153negative regulation of lymphocyte apoptotic process (GO:0070229)2.98675965
154macromolecular complex disassembly (GO:0032984)2.96840022
155lymphocyte proliferation (GO:0046651)2.96665583
156T cell costimulation (GO:0031295)2.93684707
157positive regulation of T-helper cell differentiation (GO:0045624)2.92481062
158negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91368386
159T cell activation (GO:0042110)2.88692911
160translational initiation (GO:0006413)2.88455901
161mononuclear cell proliferation (GO:0032943)2.85574634
162negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84555505
163icosanoid secretion (GO:0032309)2.84367363
164arachidonic acid secretion (GO:0050482)2.84367363
165deoxyribose phosphate catabolic process (GO:0046386)2.84060875
166deoxyribonucleotide catabolic process (GO:0009264)2.83259755
167lipopolysaccharide metabolic process (GO:0008653)2.82910782
168pyrimidine-containing compound salvage (GO:0008655)2.82381577
169pyrimidine nucleoside salvage (GO:0043097)2.82381577
170regulation of neurotransmitter uptake (GO:0051580)2.82148333
171response to pheromone (GO:0019236)2.82117140
172protein autoubiquitination (GO:0051865)2.79132408
173V(D)J recombination (GO:0033151)11.0003839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.96596904
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80458562
3MYC_22102868_ChIP-Seq_BL_Human3.75739946
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.69092004
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.68111928
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.43726397
7SCL_19346495_ChIP-Seq_HPC-7_Human3.26197363
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.20538516
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.08783121
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.03120854
11VDR_21846776_ChIP-Seq_THP-1_Human2.75508324
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71423346
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.64107290
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53788307
15* MYB_26560356_Chip-Seq_TH2_Human2.47343674
16EWS_26573619_Chip-Seq_HEK293_Human2.45899282
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43933423
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28220792
19* UTX_26944678_Chip-Seq_JUKART_Human2.24956205
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.20755693
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20051287
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15772437
23MAF_26560356_Chip-Seq_TH1_Human2.08601945
24TCF7_22412390_ChIP-Seq_EML_Mouse2.05731824
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.04708108
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01375196
27BP1_19119308_ChIP-ChIP_Hs578T_Human10.3072962
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99654833
29VDR_24763502_ChIP-Seq_THP-1_Human1.99371847
30* RUNX_20019798_ChIP-Seq_JUKART_Human1.97642805
31MYB_26560356_Chip-Seq_TH1_Human1.90837741
32CIITA_25753668_ChIP-Seq_RAJI_Human1.88450880
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86067585
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.83289980
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78765624
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.75958382
37IGF1R_20145208_ChIP-Seq_DFB_Human1.71322743
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69144840
39IRF1_19129219_ChIP-ChIP_H3396_Human1.67536690
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65711615
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64011391
42* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63997393
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62625513
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61339755
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61077751
46VDR_24787735_ChIP-Seq_THP-1_Human1.60498131
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.56932641
48* GATA3_27048872_Chip-Seq_THYMUS_Human1.56911843
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56034426
50ZNF274_21170338_ChIP-Seq_K562_Hela1.55106661
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54492647
52CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54068418
53GATA1_22025678_ChIP-Seq_K562_Human1.53760393
54MYC_18940864_ChIP-ChIP_HL60_Human1.53734821
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53671488
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52951097
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52912695
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51840855
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51449251
60SPI1_23547873_ChIP-Seq_NB4_Human1.43218648
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38998484
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38449808
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38214419
64VDR_23849224_ChIP-Seq_CD4+_Human1.37624035
65* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35669880
66KDM2B_26808549_Chip-Seq_DND41_Human1.35262556
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34810684
68SMRT_27268052_Chip-Seq_Bcells_Human1.34196545
69FOXP3_21729870_ChIP-Seq_TREG_Human1.33744770
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30488911
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28157620
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27268396
73XRN2_22483619_ChIP-Seq_HELA_Human1.26939774
74MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26924884
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.24473696
76MAF_26560356_Chip-Seq_TH2_Human1.24156355
77* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.21647773
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20104550
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20069394
80SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19969639
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18755509
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.18290125
83GABP_17652178_ChIP-ChIP_JURKAT_Human1.17798482
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17238429
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16618839
86* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16343102
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16163306
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14596128
89FUS_26573619_Chip-Seq_HEK293_Human1.14582228
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14557110
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12825951
92AR_21909140_ChIP-Seq_LNCAP_Human1.12217414
93SPI1_23127762_ChIP-Seq_K562_Human1.11707463
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10855994
95* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09610768
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.08454639
97* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06829875
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04012961
99TP53_22573176_ChIP-Seq_HFKS_Human1.01568596
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01530910
101IRF8_27001747_Chip-Seq_BMDM_Mouse0.99498245
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99018985
103NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96802599
104KDM5A_27292631_Chip-Seq_BREAST_Human0.96030998
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94476601
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94140880
107* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93916284
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93015340
109BCL6_27268052_Chip-Seq_Bcells_Human0.93015333
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92529357
111ELK1_19687146_ChIP-ChIP_HELA_Human0.91939639
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.89464977
113* P300_27268052_Chip-Seq_Bcells_Human0.89065373
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88917276
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88849130
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88234013
117FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88058539
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.86514475
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86111820
120AR_20517297_ChIP-Seq_VCAP_Human0.85329215
121JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84793176
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.83989415
123GATA3_26560356_Chip-Seq_TH2_Human0.83842609
124ETS1_20019798_ChIP-Seq_JURKAT_Human0.82575782
125* PRDM14_20953172_ChIP-Seq_ESCs_Human0.82499316
126* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81820122
127YY1_21170310_ChIP-Seq_MESCs_Mouse0.81571963
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81514414
129* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81508505
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80393088
131* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.80272204
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78716091
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78384263
134P53_21459846_ChIP-Seq_SAOS-2_Human0.78247844
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77545903
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76528444
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75981768
138PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75660961
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75462706
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75258261
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.75203247
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75017061
143FOXA1_25329375_ChIP-Seq_VCAP_Human0.75017061
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74714345
145CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74566934
146FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73987424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.88471145
2MP0003763_abnormal_thymus_physiology4.12638749
3MP0002396_abnormal_hematopoietic_system3.87774666
4MP0009278_abnormal_bone_marrow3.68421435
5MP0002166_altered_tumor_susceptibility3.62655230
6MP0005409_darkened_coat_color3.43554454
7MP0010094_abnormal_chromosome_stability3.42973750
8MP0000703_abnormal_thymus_morphology3.41105436
9MP0005671_abnormal_response_to3.28006636
10MP0001835_abnormal_antigen_presentation2.98738134
11MP0001545_abnormal_hematopoietic_system2.89059893
12MP0005397_hematopoietic_system_phenotyp2.89059893
13MP0002006_tumorigenesis2.81575724
14MP0004808_abnormal_hematopoietic_stem2.76289749
15* MP0002398_abnormal_bone_marrow2.66884678
16MP0009785_altered_susceptibility_to2.65363930
17MP0008007_abnormal_cellular_replicative2.59981029
18MP0002722_abnormal_immune_system2.37532717
19MP0000689_abnormal_spleen_morphology2.25195211
20MP0001800_abnormal_humoral_immune2.24126171
21MP0004947_skin_inflammation2.24017429
22* MP0000716_abnormal_immune_system2.15679653
23MP0004084_abnormal_cardiac_muscle2.13621420
24MP0010155_abnormal_intestine_physiology2.11069288
25* MP0000685_abnormal_immune_system2.05997982
26MP0002420_abnormal_adaptive_immunity2.04707304
27MP0001819_abnormal_immune_cell2.00697095
28MP0005174_abnormal_tail_pigmentation1.97447027
29MP0002723_abnormal_immune_serum1.95422957
30MP0002132_abnormal_respiratory_system1.90974841
31MP0009333_abnormal_splenocyte_physiolog1.88516951
32MP0002095_abnormal_skin_pigmentation1.87201703
33MP0000490_abnormal_crypts_of1.86187071
34MP0003693_abnormal_embryo_hatching1.85332559
35* MP0002429_abnormal_blood_cell1.85238285
36MP0002405_respiratory_system_inflammati1.81726012
37MP0005025_abnormal_response_to1.79105297
38MP0002452_abnormal_antigen_presenting1.77070911
39MP0001790_abnormal_immune_system1.68072750
40MP0005387_immune_system_phenotype1.68072750
41MP0003077_abnormal_cell_cycle1.59001406
42* MP0005000_abnormal_immune_tolerance1.58198913
43MP0002019_abnormal_tumor_incidence1.55364167
44MP0001853_heart_inflammation1.54192986
45MP0002148_abnormal_hypersensitivity_rea1.53515679
46MP0009697_abnormal_copulation1.53214514
47MP0005464_abnormal_platelet_physiology1.51912677
48MP0003283_abnormal_digestive_organ1.51803324
49MP0000015_abnormal_ear_pigmentation1.50595574
50MP0008057_abnormal_DNA_replication1.48174010
51MP0004957_abnormal_blastocyst_morpholog1.45638384
52MP0005075_abnormal_melanosome_morpholog1.45244807
53MP0002138_abnormal_hepatobiliary_system1.43540480
54MP0010352_gastrointestinal_tract_polyps1.42788410
55MP0001849_ear_inflammation1.42382416
56MP0003111_abnormal_nucleus_morphology1.41836400
57MP0003300_gastrointestinal_ulcer1.38165658
58MP0002876_abnormal_thyroid_physiology1.33568278
59MP0008058_abnormal_DNA_repair1.33496427
60MP0002419_abnormal_innate_immunity1.27584287
61MP0004381_abnormal_hair_follicle1.23142374
62MP0006054_spinal_hemorrhage1.20227248
63MP0000465_gastrointestinal_hemorrhage1.18948902
64MP0003866_abnormal_defecation1.15185615
65MP0001845_abnormal_inflammatory_respons1.11210392
66MP0003252_abnormal_bile_duct1.07377314
67MP0008872_abnormal_physiological_respon1.06600467
68MP0001873_stomach_inflammation1.05621605
69MP0002933_joint_inflammation1.05134281
70MP0002075_abnormal_coat/hair_pigmentati1.04018194
71MP0000350_abnormal_cell_proliferation1.03861610
72MP0001905_abnormal_dopamine_level1.03020626
73MP0003436_decreased_susceptibility_to0.94650418
74MP0008877_abnormal_DNA_methylation0.91847906
75MP0004036_abnormal_muscle_relaxation0.91745773
76MP0008775_abnormal_heart_ventricle0.91705228
77MP0000383_abnormal_hair_follicle0.90562604
78MP0003724_increased_susceptibility_to0.89088223
79MP0005365_abnormal_bile_salt0.88509969
80MP0000013_abnormal_adipose_tissue0.88128301
81MP0002127_abnormal_cardiovascular_syste0.85964838
82MP0001879_abnormal_lymphatic_vessel0.85575647
83MP0000470_abnormal_stomach_morphology0.82165844
84MP0008469_abnormal_protein_level0.81451857
85MP0008875_abnormal_xenobiotic_pharmacok0.79681224
86MP0010307_abnormal_tumor_latency0.78654303
87MP0001243_abnormal_dermal_layer0.78423995
88MP0000858_altered_metastatic_potential0.77328915
89MP0000313_abnormal_cell_death0.76534365
90MP0002009_preneoplasia0.75843368
91MP0005220_abnormal_exocrine_pancreas0.74991289
92MP0000462_abnormal_digestive_system0.74964462
93MP0002998_abnormal_bone_remodeling0.73665308
94MP0006082_CNS_inflammation0.72857161
95MP0006072_abnormal_retinal_apoptosis0.72079388
96MP0004130_abnormal_muscle_cell0.68233436
97MP0000477_abnormal_intestine_morphology0.66618038
98MP0001186_pigmentation_phenotype0.65204617
99MP0000609_abnormal_liver_physiology0.64158665
100MP0002970_abnormal_white_adipose0.63763331
101MP0008770_decreased_survivor_rate0.63319096
102MP0001730_embryonic_growth_arrest0.62042818
103MP0001542_abnormal_bone_strength0.62015320
104MP0003868_abnormal_feces_composition0.61742055
105MP0010678_abnormal_skin_adnexa0.61071620
106MP0009765_abnormal_xenobiotic_induced0.58832843
107MP0001177_atelectasis0.58538947
108MP0000377_abnormal_hair_follicle0.58101523
109MP0002083_premature_death0.55461734
110MP0000367_abnormal_coat/_hair0.55274397
111MP0003959_abnormal_lean_body0.54884974
112MP0008873_increased_physiological_sensi0.53988085
113MP0003943_abnormal_hepatobiliary_system0.53039377
114MP0002060_abnormal_skin_morphology0.51834824
115MP0001944_abnormal_pancreas_morphology0.50431917
116MP0002080_prenatal_lethality0.49140245
117MP0005381_digestive/alimentary_phenotyp0.48696421
118MP0005584_abnormal_enzyme/coenzyme_acti0.48406260
119MP0001663_abnormal_digestive_system0.48226256
120MP0004043_abnormal_pH_regulation0.48069314
121MP0009931_abnormal_skin_appearance0.47863244
122MP0003828_pulmonary_edema0.47240693
123MP0001191_abnormal_skin_condition0.45335803
124MP0006292_abnormal_olfactory_placode0.44857705
125MP0009764_decreased_sensitivity_to0.44692925
126MP0000249_abnormal_blood_vessel0.43685442
127MP0005645_abnormal_hypothalamus_physiol0.43556163
128MP0002653_abnormal_ependyma_morphology0.42904492
129MP0005360_urolithiasis0.40157943
130MP0001529_abnormal_vocalization0.39385143
131MP0002160_abnormal_reproductive_system0.39206231
132MP0001216_abnormal_epidermal_layer0.37760161
133MP0006138_congestive_heart_failure0.36946171
134MP0003183_abnormal_peptide_metabolism0.35748250
135MP0005084_abnormal_gallbladder_morpholo0.33418563
136MP0004133_heterotaxia0.31527641
137MP0003795_abnormal_bone_structure0.29616516
138MP0001440_abnormal_grooming_behavior0.29442049
139MP0005389_reproductive_system_phenotype0.27816645

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)9.96376804
2B lymphocytopenia (HP:0010976)9.96376804
3Hypoplasia of the thymus (HP:0000778)8.73105741
4Thyroiditis (HP:0100646)8.59568453
5T lymphocytopenia (HP:0005403)8.48531262
6Severe combined immunodeficiency (HP:0004430)7.97986144
7Panhypogammaglobulinemia (HP:0003139)7.95052862
8Abnormality of T cell number (HP:0011839)7.94911646
9Combined immunodeficiency (HP:0005387)6.88819873
10Eosinophilia (HP:0001880)6.38088240
11Recurrent viral infections (HP:0004429)6.26486501
12Hypoproteinemia (HP:0003075)6.14501122
13Granulocytopenia (HP:0001913)5.39286658
14Abnormality of eosinophils (HP:0001879)4.80586838
15Abnormality of T cells (HP:0002843)4.77098870
16IgG deficiency (HP:0004315)4.71091738
17Recurrent fungal infections (HP:0002841)4.13877350
18Acute lymphatic leukemia (HP:0006721)4.12849895
19Chronic otitis media (HP:0000389)3.95273987
20Erythroderma (HP:0001019)3.77137263
21Elevated erythrocyte sedimentation rate (HP:0003565)3.49670999
22Leukocytosis (HP:0001974)3.37770672
23Aplasia/Hypoplasia of the thymus (HP:0010515)3.33366481
24Meningitis (HP:0001287)3.28941214
25Papilloma (HP:0012740)3.03868970
26Verrucae (HP:0200043)3.03868970
27Recurrent bronchitis (HP:0002837)3.01515690
28Agammaglobulinemia (HP:0004432)2.95473598
29Reticulocytopenia (HP:0001896)2.89868135
30Abnormality of cells of the erythroid lineage (HP:0012130)2.88483601
31Abnormality of the fingertips (HP:0001211)2.78718095
32Abnormality of the thymus (HP:0000777)2.78017923
33Abnormal number of erythroid precursors (HP:0012131)2.71733366
34Lymphoma (HP:0002665)2.66183466
35IgM deficiency (HP:0002850)2.58411166
36Sepsis (HP:0100806)2.50476097
37Cellulitis (HP:0100658)2.49211530
38Recurrent pneumonia (HP:0006532)2.42396894
39Nasal polyposis (HP:0100582)2.42327311
40Acute myeloid leukemia (HP:0004808)2.39042155
41Thrombocytosis (HP:0001894)2.38942217
42Autoimmune hemolytic anemia (HP:0001890)2.37791662
43Chronic sinusitis (HP:0011109)2.23783937
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.15311172
45Poikiloderma (HP:0001029)2.13319512
46Abnormality of the nasal mucosa (HP:0000433)2.06376378
47Aplastic anemia (HP:0001915)2.01619284
48Cutaneous melanoma (HP:0012056)2.00203487
49Cutis marmorata (HP:0000965)1.99343242
50Myositis (HP:0100614)1.96840769
51Bicuspid aortic valve (HP:0001647)1.92582126
52Abnormality of T cell physiology (HP:0011840)1.91603243
53Muscle fiber atrophy (HP:0100295)1.91388205
54Entropion (HP:0000621)1.90171386
55Type 2 muscle fiber atrophy (HP:0003554)1.88831664
56Macrocytic anemia (HP:0001972)1.86664309
57Cellular immunodeficiency (HP:0005374)1.82839660
58Lymphopenia (HP:0001888)1.80725544
59Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80708799
60Chronic mucocutaneous candidiasis (HP:0002728)1.80462558
61Recurrent cutaneous fungal infections (HP:0011370)1.80462558
62Abnormality of cells of the lymphoid lineage (HP:0012140)1.78649544
63Hyperacusis (HP:0010780)1.77037044
64Volvulus (HP:0002580)1.75779670
65Gastrointestinal inflammation (HP:0004386)1.71624213
66Basal cell carcinoma (HP:0002671)1.69983743
67Pruritus (HP:0000989)1.69970280
68Recurrent lower respiratory tract infections (HP:0002783)1.68964676
69Colitis (HP:0002583)1.65144976
70Nephrotic syndrome (HP:0000100)1.64851657
71Bronchitis (HP:0012387)1.64511565
72Osteomyelitis (HP:0002754)1.61547867
73Inflammation of the large intestine (HP:0002037)1.59785808
74Autoimmune thrombocytopenia (HP:0001973)1.58508501
75Pallor (HP:0000980)1.54833828
76Long eyelashes (HP:0000527)1.51465699
77Colon cancer (HP:0003003)1.49999977
78Abnormality of the intervertebral disk (HP:0005108)1.48771791
79Amaurosis fugax (HP:0100576)1.45823148
80Increased nuchal translucency (HP:0010880)1.45537060
81Prolonged bleeding time (HP:0003010)1.43422974
82Encephalitis (HP:0002383)1.43150108
83Spontaneous hematomas (HP:0007420)1.40584083
84Recurrent abscess formation (HP:0002722)1.35393611
85Pancytopenia (HP:0001876)1.34555223
86Recurrent skin infections (HP:0001581)1.32808417
87Dehydration (HP:0001944)1.32741279
88Chronic diarrhea (HP:0002028)1.32042643
89Squamous cell carcinoma (HP:0002860)1.31675071
90Skin rash (HP:0000988)1.30819218
91Myelodysplasia (HP:0002863)1.29716438
92Interstitial pulmonary disease (HP:0006530)1.27870096
93Prostate neoplasm (HP:0100787)1.26486434
94Pustule (HP:0200039)1.24881992
95Broad alveolar ridges (HP:0000187)1.22458872
96Broad palm (HP:0001169)1.22369419
97Deep philtrum (HP:0002002)1.20353281
98Recurrent bacterial skin infections (HP:0005406)1.19475738
99Overlapping toe (HP:0001845)1.18946259
100Abnormality of DNA repair (HP:0003254)1.18362545
10111 pairs of ribs (HP:0000878)1.18251302
102Skin ulcer (HP:0200042)1.17669750
103Stomach cancer (HP:0012126)1.16554306
104Abnormality of oral frenula (HP:0000190)1.16364876
105Mesangial abnormality (HP:0001966)1.16184575
106Neutropenia (HP:0001875)1.15913712
107Recurrent otitis media (HP:0000403)1.15592194
108Hypoplasia of the pons (HP:0012110)1.15582599
109Bronchiectasis (HP:0002110)1.15433293
110Abnormality of the columella (HP:0009929)1.15399407
111Abnormality of the pons (HP:0007361)1.11146257
112Abnormality of the prostate (HP:0008775)1.10926099
113Visual hallucinations (HP:0002367)1.10512482
114Increased IgE level (HP:0003212)1.08784287
115Constricted visual fields (HP:0001133)1.06815791
116Nonimmune hydrops fetalis (HP:0001790)1.00325397
117Dry skin (HP:0000958)0.99628663
118Hypothyroidism (HP:0000821)0.97999951
119Abnormal pancreas size (HP:0012094)0.93426425
120Methylmalonic acidemia (HP:0002912)0.92644024
121Carpal bone hypoplasia (HP:0001498)0.90952491
122Multiple enchondromatosis (HP:0005701)0.89365562
123Acute hepatic failure (HP:0006554)0.88468441
124Polygenic inheritance (HP:0010982)0.87798374
125External ear malformation (HP:0008572)0.87715237
126Type I transferrin isoform profile (HP:0003642)0.87236723
127Small epiphyses (HP:0010585)0.86316779
128Cupped ribs (HP:0000887)0.86174440
129Abnormal rod and cone electroretinograms (HP:0008323)0.81661328
130Abnormal foot bone ossification (HP:0010675)0.80697401
131Chronic hepatic failure (HP:0100626)0.79954399
132Abnormality of endocrine pancreas physiology (HP:0012093)0.79439293
133Abnormality of the pancreatic islet cells (HP:0006476)0.79439293
134Abnormal tarsal ossification (HP:0008369)0.76663492
135Barrel-shaped chest (HP:0001552)0.74863779
136Attenuation of retinal blood vessels (HP:0007843)0.72710289
137Lower limb hyperreflexia (HP:0002395)0.71813055
138Hypokalemic alkalosis (HP:0001949)0.71145898
139Abnormality of the fingernails (HP:0001231)0.70203701
140Hematochezia (HP:0002573)0.70010544
141Methylmalonic aciduria (HP:0012120)0.68538714
142Infantile onset (HP:0003593)0.64985937
143Abnormality of male internal genitalia (HP:0000022)0.63968437
144Abnormality of dicarboxylic acid metabolism (HP:0010995)0.60698228
145Dicarboxylic aciduria (HP:0003215)0.60698228
146Papilledema (HP:0001085)0.60468854
147Focal motor seizures (HP:0011153)0.58170812
148Metabolic alkalosis (HP:0200114)0.56635669
149Large eyes (HP:0001090)0.55486538
150Fatigue (HP:0012378)0.55129106
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.55040556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET5.31105426
2FLT34.66918207
3EEF2K4.19244385
4BMPR1B4.04383992
5MAP3K133.81758895
6MAP3K103.59788199
7MAP4K13.12398986
8KIT2.94177748
9GRK62.45118513
10PIK3CG2.42290307
11ERN12.40664398
12TXK2.38620532
13RPS6KB22.38451487
14MST42.35742344
15CDC72.34949536
16CDK82.27461931
17CSF1R2.26215799
18PKN22.13978800
19SYK2.08781147
20VRK22.03462973
21NME21.83659839
22ZAP701.83421253
23MAP3K141.83377554
24YES11.74151967
25NLK1.73978566
26ITK1.69315642
27BTK1.67242223
28NEK21.61874913
29TEC1.61329975
30RPS6KB11.56073195
31FRK1.52724657
32LRRK21.51680414
33STK101.48572456
34RIPK41.47673689
35MAP3K71.44077872
36ADRBK21.44019055
37TLK11.43052681
38MAPK41.34181347
39FGFR21.32724744
40MAPK111.29395498
41WEE11.28186080
42TSSK61.27203106
43SCYL21.25563084
44KDR1.22341800
45MAPKAPK31.20224691
46MAPK71.18710243
47TYK21.18566313
48MAPK121.13432284
49LCK1.13336829
50EIF2AK31.13198398
51PLK21.11576520
52STK41.11574822
53TESK21.09580474
54TNIK1.08988097
55PIM11.08326775
56MAPK131.06903846
57PRKCH1.05502278
58FGFR31.05039920
59SIK21.04460205
60CLK11.02602787
61HIPK20.99119225
62CDK40.98904264
63FGFR40.97737269
64BCKDK0.93306143
65TBK10.93085909
66PASK0.91738868
67HCK0.91733664
68PDGFRB0.89188879
69CSK0.87372415
70FES0.87298586
71SRPK10.86316169
72CDK60.85887540
73PTK60.85258720
74ATR0.84901009
75BUB10.84063124
76DYRK30.83552223
77CDK120.83162872
78PRKD20.81766642
79DAPK10.79468624
80MAP3K110.79034768
81TGFBR10.74217437
82CCNB10.73772828
83TGFBR20.72679129
84MAPKAPK50.68938445
85ZAK0.64778915
86ACVR1B0.63223798
87PIM20.61382426
88MARK20.61045367
89JAK30.60194600
90CDK90.60039376
91LYN0.59700029
92CAMK10.59205270
93TYRO30.58709048
94BMPR20.57203918
95DYRK1A0.56433516
96TRPM70.55323965
97DYRK1B0.54828809
98PINK10.53554644
99TAOK30.53455644
100VRK10.53432431
101TRIB30.52928213
102EGFR0.52768991
103STK110.51591325
104PRKCI0.50400845
105ARAF0.50127993
106BRD40.49868130
107UHMK10.49821014
108IKBKE0.49682528
109STK390.48803838
110MARK30.47884288
111PRKCQ0.47833747
112MAP3K120.47428069
113NUAK10.47094627
114MAP3K80.46404266
115CDK30.45602093
116PAK20.44406835
117WNK40.43117189
118RPS6KA20.41197631
119CHEK10.40282527
120JAK20.40072842
121AURKB0.39860931
122STK160.39318066
123MAPK30.38326516
124CDK70.36542599
125IKBKB0.36446609
126CSNK1A1L0.36270594
127ERBB20.35844933
128MKNK10.35406732
129RPS6KA60.34761626
130INSRR0.34521437
131RPS6KA40.34382923
132TAF10.34276266
133RAF10.34066335
134EPHB10.33792552
135CDK190.33664329
136ATM0.32024211
137CDK20.31799616
138PRKDC0.30703912
139RPS6KC10.30330136
140RPS6KL10.30330136
141NTRK20.29967734
142CSNK1D0.29828391
143PRKCE0.29425568
144DYRK20.29072762
145MKNK20.27712951
146WNK10.26204712
147ABL10.25247831
148MAP2K20.22789305
149IGF1R0.22308615
150INSR0.21931754
151GRK10.20987674

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.58286776
2DNA replication_Homo sapiens_hsa030304.29959507
3* Non-homologous end-joining_Homo sapiens_hsa034503.57291041
4Caffeine metabolism_Homo sapiens_hsa002323.28786356
5Mismatch repair_Homo sapiens_hsa034303.13687164
6Ribosome_Homo sapiens_hsa030103.12423199
7Asthma_Homo sapiens_hsa053102.92939070
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.79216340
9Base excision repair_Homo sapiens_hsa034102.65818995
10T cell receptor signaling pathway_Homo sapiens_hsa046602.61382746
11Autoimmune thyroid disease_Homo sapiens_hsa053202.42246649
12Graft-versus-host disease_Homo sapiens_hsa053322.32799648
13Antigen processing and presentation_Homo sapiens_hsa046122.31781312
14Acute myeloid leukemia_Homo sapiens_hsa052212.02699232
15Spliceosome_Homo sapiens_hsa030401.93343659
16Systemic lupus erythematosus_Homo sapiens_hsa053221.88455017
17Thyroid cancer_Homo sapiens_hsa052161.87717625
18Measles_Homo sapiens_hsa051621.81004308
19Cell cycle_Homo sapiens_hsa041101.77636017
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74364329
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.69565841
22B cell receptor signaling pathway_Homo sapiens_hsa046621.66998225
23* Hematopoietic cell lineage_Homo sapiens_hsa046401.66705566
24Homologous recombination_Homo sapiens_hsa034401.60130722
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.56617480
26Nucleotide excision repair_Homo sapiens_hsa034201.47618243
27Chronic myeloid leukemia_Homo sapiens_hsa052201.34626338
28Allograft rejection_Homo sapiens_hsa053301.30502918
29Pyrimidine metabolism_Homo sapiens_hsa002401.30480636
30Herpes simplex infection_Homo sapiens_hsa051681.29881243
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25212614
32Pentose phosphate pathway_Homo sapiens_hsa000301.25176404
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.25092689
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23645880
35Colorectal cancer_Homo sapiens_hsa052101.20139827
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16970107
37Leishmaniasis_Homo sapiens_hsa051401.12465052
38Viral carcinogenesis_Homo sapiens_hsa052031.11708345
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11503054
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10222811
41Alcoholism_Homo sapiens_hsa050341.06081053
42One carbon pool by folate_Homo sapiens_hsa006701.05429217
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.03024625
44Staphylococcus aureus infection_Homo sapiens_hsa051501.02359141
45Non-small cell lung cancer_Homo sapiens_hsa052231.01260326
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01060488
47HTLV-I infection_Homo sapiens_hsa051660.99918249
48Hepatitis B_Homo sapiens_hsa051610.96207126
49RNA degradation_Homo sapiens_hsa030180.95399394
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93362409
51Osteoclast differentiation_Homo sapiens_hsa043800.86830089
52Legionellosis_Homo sapiens_hsa051340.86215153
53Arachidonic acid metabolism_Homo sapiens_hsa005900.85742865
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.84666535
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83273244
56Endometrial cancer_Homo sapiens_hsa052130.79211213
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78150476
58Linoleic acid metabolism_Homo sapiens_hsa005910.76716091
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76576046
60RNA transport_Homo sapiens_hsa030130.76331122
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72050267
62Fanconi anemia pathway_Homo sapiens_hsa034600.71250175
63Influenza A_Homo sapiens_hsa051640.70849306
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70768008
65Phototransduction_Homo sapiens_hsa047440.68606905
66Peroxisome_Homo sapiens_hsa041460.68425017
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.67284789
68Renin-angiotensin system_Homo sapiens_hsa046140.66712866
69Type I diabetes mellitus_Homo sapiens_hsa049400.64335315
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63549050
71Epstein-Barr virus infection_Homo sapiens_hsa051690.63243322
72mRNA surveillance pathway_Homo sapiens_hsa030150.62672891
73Rheumatoid arthritis_Homo sapiens_hsa053230.59686453
74African trypanosomiasis_Homo sapiens_hsa051430.58871303
75Toxoplasmosis_Homo sapiens_hsa051450.58508306
76Regulation of autophagy_Homo sapiens_hsa041400.58487999
77Propanoate metabolism_Homo sapiens_hsa006400.57962989
78Prostate cancer_Homo sapiens_hsa052150.56641662
79Ether lipid metabolism_Homo sapiens_hsa005650.56076041
80MicroRNAs in cancer_Homo sapiens_hsa052060.55811179
81Lysine degradation_Homo sapiens_hsa003100.55224401
82FoxO signaling pathway_Homo sapiens_hsa040680.54870938
83Chemokine signaling pathway_Homo sapiens_hsa040620.54506163
84Purine metabolism_Homo sapiens_hsa002300.54441556
85Pancreatic cancer_Homo sapiens_hsa052120.52769841
86Notch signaling pathway_Homo sapiens_hsa043300.52737184
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50731092
88Platelet activation_Homo sapiens_hsa046110.50266095
89p53 signaling pathway_Homo sapiens_hsa041150.49032834
90Small cell lung cancer_Homo sapiens_hsa052220.48730656
91Apoptosis_Homo sapiens_hsa042100.45979258
92Pertussis_Homo sapiens_hsa051330.45577841
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45352846
94Shigellosis_Homo sapiens_hsa051310.43523461
95mTOR signaling pathway_Homo sapiens_hsa041500.40397548
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37594414
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.36739232
98Selenocompound metabolism_Homo sapiens_hsa004500.36606650
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.35688387
100Malaria_Homo sapiens_hsa051440.34721397
101Fatty acid biosynthesis_Homo sapiens_hsa000610.34586773
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32883924
103Dorso-ventral axis formation_Homo sapiens_hsa043200.32474553
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32451831
105Parkinsons disease_Homo sapiens_hsa050120.31495174
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31293088
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31162415
108Proteasome_Homo sapiens_hsa030500.30595156
109Pathways in cancer_Homo sapiens_hsa052000.28117573
110Biosynthesis of amino acids_Homo sapiens_hsa012300.26508182
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.25859340
112N-Glycan biosynthesis_Homo sapiens_hsa005100.25033828
113Glutathione metabolism_Homo sapiens_hsa004800.24690400
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24647291
115Sulfur relay system_Homo sapiens_hsa041220.24645276
116Alzheimers disease_Homo sapiens_hsa050100.24336923
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24214737
118RNA polymerase_Homo sapiens_hsa030200.24098364
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23895974
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22818238
121Chemical carcinogenesis_Homo sapiens_hsa052040.20867397
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20856985
123Hepatitis C_Homo sapiens_hsa051600.20100752
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20045939
125Glioma_Homo sapiens_hsa052140.19193642
126Viral myocarditis_Homo sapiens_hsa054160.18854750
127ErbB signaling pathway_Homo sapiens_hsa040120.18476000
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18457739
129Oxidative phosphorylation_Homo sapiens_hsa001900.17385494
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17326046
131ABC transporters_Homo sapiens_hsa020100.17152124
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.16676428
133Tuberculosis_Homo sapiens_hsa051520.16368943
134Nitrogen metabolism_Homo sapiens_hsa009100.15994408
135Renal cell carcinoma_Homo sapiens_hsa052110.15486989
136Insulin resistance_Homo sapiens_hsa049310.10361655
137Type II diabetes mellitus_Homo sapiens_hsa049300.09540891
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09093476
139Melanoma_Homo sapiens_hsa052180.08202601

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