DNTTIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.94407879
2translational termination (GO:0006415)9.46313261
3ribosomal small subunit biogenesis (GO:0042274)8.82275386
4ribosomal small subunit assembly (GO:0000028)8.57013201
5translational elongation (GO:0006414)8.03821140
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.98215107
7protein targeting to ER (GO:0045047)7.84045904
8cotranslational protein targeting to membrane (GO:0006613)7.81798988
9establishment of protein localization to endoplasmic reticulum (GO:0072599)7.52650852
10viral life cycle (GO:0019058)7.52431403
11cellular protein complex disassembly (GO:0043624)7.44238252
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.36332094
13protein localization to endoplasmic reticulum (GO:0070972)7.28485833
14translational initiation (GO:0006413)6.90313912
15maturation of SSU-rRNA (GO:0030490)6.85203930
16protein complex disassembly (GO:0043241)6.77355085
17macromolecular complex disassembly (GO:0032984)6.33897312
18ribosomal large subunit biogenesis (GO:0042273)5.42323454
19protein targeting to membrane (GO:0006612)5.32004161
20nuclear-transcribed mRNA catabolic process (GO:0000956)4.95760259
21protein maturation by protein folding (GO:0022417)4.79119624
22mRNA catabolic process (GO:0006402)4.69873438
23ncRNA 3-end processing (GO:0043628)4.69599610
24translation (GO:0006412)4.60788325
25RNA catabolic process (GO:0006401)4.47659763
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.25830772
27ribonucleoprotein complex biogenesis (GO:0022613)4.13265939
28nuclear envelope reassembly (GO:0031468)3.83397078
29mitotic nuclear envelope reassembly (GO:0007084)3.83397078
30proteasome assembly (GO:0043248)3.83391211
31pyrimidine-containing compound salvage (GO:0008655)3.83231019
32pyrimidine nucleoside salvage (GO:0043097)3.83231019
33establishment of viral latency (GO:0019043)3.81990781
34establishment of protein localization to membrane (GO:0090150)3.70151225
35regulation of mitochondrial translation (GO:0070129)3.62575330
36pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.59068633
37negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.55928446
38pyrimidine nucleotide catabolic process (GO:0006244)3.52070887
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50090657
40establishment of integrated proviral latency (GO:0075713)3.46529653
41DNA damage response, detection of DNA damage (GO:0042769)3.44080948
42regulation of superoxide anion generation (GO:0032928)3.43968672
43nucleoside salvage (GO:0043174)3.43334245
44negative regulation of RNA splicing (GO:0033119)3.33972518
45formation of translation preinitiation complex (GO:0001731)3.32917766
46DNA unwinding involved in DNA replication (GO:0006268)3.31242601
47negative regulation of ligase activity (GO:0051352)3.27950582
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27950582
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27613422
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27126502
51protein targeting (GO:0006605)3.26885165
52DNA deamination (GO:0045006)3.24480531
53rRNA processing (GO:0006364)3.20997910
54chaperone-mediated protein transport (GO:0072321)3.20496473
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19035823
56trophectodermal cell differentiation (GO:0001829)3.18586482
57heme biosynthetic process (GO:0006783)3.16631806
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14347653
59maternal placenta development (GO:0001893)3.13361107
60rRNA metabolic process (GO:0016072)3.12346744
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12199090
62establishment of protein localization to organelle (GO:0072594)3.11730555
63base-excision repair, AP site formation (GO:0006285)3.07482108
64chaperone mediated protein folding requiring cofactor (GO:0051085)3.07129316
65protein targeting to mitochondrion (GO:0006626)3.03584247
66deoxyribonucleotide catabolic process (GO:0009264)3.03212324
67GDP-mannose metabolic process (GO:0019673)3.02944970
68COPI coating of Golgi vesicle (GO:0048205)3.01206066
69Golgi transport vesicle coating (GO:0048200)3.01206066
70deoxyribose phosphate catabolic process (GO:0046386)3.00435262
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99801607
72guanosine-containing compound biosynthetic process (GO:1901070)2.98857336
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.97791340
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96908603
75regulation of cellular amino acid metabolic process (GO:0006521)2.96108470
76cellular component biogenesis (GO:0044085)2.95543613
77UTP biosynthetic process (GO:0006228)2.95105371
78metallo-sulfur cluster assembly (GO:0031163)2.94141154
79iron-sulfur cluster assembly (GO:0016226)2.94141154
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92826919
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92826919
82alternative mRNA splicing, via spliceosome (GO:0000380)2.92568941
83response to peptidoglycan (GO:0032494)2.92376184
84nucleosome disassembly (GO:0006337)2.91786166
85protein-DNA complex disassembly (GO:0032986)2.91786166
86negative regulation of DNA-templated transcription, elongation (GO:0032785)2.91115787
87positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90186161
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88073573
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88073573
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88073573
91cellular component disassembly (GO:0022411)2.88036121
92ribosome biogenesis (GO:0042254)2.87612144
93GTP biosynthetic process (GO:0006183)2.87309797
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.86755546
95regulation of protein heterodimerization activity (GO:0043497)2.86248060
96negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.86242597
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.85179070
98rRNA modification (GO:0000154)2.84367082
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84093765
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.84093765
101DNA strand elongation involved in DNA replication (GO:0006271)2.79420056
102positive regulation of ligase activity (GO:0051351)2.79002040
103protein localization to membrane (GO:0072657)2.78629159
104megakaryocyte development (GO:0035855)2.78278620
105pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.77735369
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.76809630
107viral protein processing (GO:0019082)2.76081041
1083-UTR-mediated mRNA stabilization (GO:0070935)2.76074076
109de novo protein folding (GO:0006458)2.76048785
110establishment of protein localization to mitochondrion (GO:0072655)2.74855625
111telomere maintenance via semi-conservative replication (GO:0032201)2.74437606
112Arp2/3 complex-mediated actin nucleation (GO:0034314)2.72012990
113positive regulation by organism of defense response of other organism involved in symbiotic interact2.71313781
114modulation by symbiont of host immune response (GO:0052553)2.71313781
115positive regulation by symbiont of host defense response (GO:0052509)2.71313781
116modulation by symbiont of host defense response (GO:0052031)2.71313781
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71313781
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71313781
119T cell apoptotic process (GO:0070231)2.71043873
120CTP biosynthetic process (GO:0006241)2.70926388
121CTP metabolic process (GO:0046036)2.70926388
122neutrophil activation involved in immune response (GO:0002283)2.70078605
123porphyrin-containing compound biosynthetic process (GO:0006779)2.68984592
1242-deoxyribonucleotide biosynthetic process (GO:0009265)2.68777237
125deoxyribose phosphate biosynthetic process (GO:0046385)2.68777237
126DNA strand elongation (GO:0022616)2.68253184
127protein localization to mitochondrion (GO:0070585)2.68246770
128de novo posttranslational protein folding (GO:0051084)2.68013931
129virion assembly (GO:0019068)2.66690306
130heterochromatin organization (GO:0070828)2.66183378
131negative regulation of erythrocyte differentiation (GO:0045647)2.65957246
132spliceosomal snRNP assembly (GO:0000387)2.64577084
133spliceosomal complex assembly (GO:0000245)2.64343511
134nucleobase-containing small molecule interconversion (GO:0015949)2.62927368
135folic acid-containing compound biosynthetic process (GO:0009396)2.62233093
136lipopolysaccharide metabolic process (GO:0008653)2.61428721
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.61389184
138positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59502337
139ATP synthesis coupled proton transport (GO:0015986)2.59056643
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.59056643
1412-deoxyribonucleotide metabolic process (GO:0009394)2.57594097
142UTP metabolic process (GO:0046051)2.56186527
143pentose metabolic process (GO:0019321)2.55548259
144negative regulation of mRNA processing (GO:0050686)2.54351816
145regulation of ligase activity (GO:0051340)2.53223108
146deoxyribose phosphate metabolic process (GO:0019692)2.52778087
147pinocytosis (GO:0006907)2.52719373
148negative regulation of B cell apoptotic process (GO:0002903)2.52005150
149negative regulation of mRNA metabolic process (GO:1903312)2.51648110
150lipopolysaccharide biosynthetic process (GO:0009103)2.50965382
151pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.49631861
152negative regulation of myeloid cell apoptotic process (GO:0033033)2.49007917
153protoporphyrinogen IX metabolic process (GO:0046501)2.47868242
154pentose-phosphate shunt (GO:0006098)2.44097891
155mitochondrial calcium ion transport (GO:0006851)2.43643715
156antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.43307799
157negative regulation of protein ubiquitination (GO:0031397)2.42724918
158pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42461703
159peptidyl-arginine omega-N-methylation (GO:0035247)2.42422829
160pyrimidine nucleoside biosynthetic process (GO:0046134)2.41079064
161DNA replication checkpoint (GO:0000076)2.40784172
162establishment of protein localization to mitochondrial membrane (GO:0090151)2.40500000
163termination of RNA polymerase II transcription (GO:0006369)2.39136891
164chromatin assembly (GO:0031497)2.36759383
165lymphocyte apoptotic process (GO:0070227)2.34058524
166RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.31768514
167mRNA splicing, via spliceosome (GO:0000398)2.31768514
168pteridine-containing compound biosynthetic process (GO:0042559)2.28588744
169positive regulation of transcription regulatory region DNA binding (GO:2000679)2.27745999
170protein localization to organelle (GO:0033365)2.27376739
171RNA splicing, via transesterification reactions (GO:0000375)2.27066486
172regulation of chromatin binding (GO:0035561)2.26647016
173tetrapyrrole biosynthetic process (GO:0033014)2.25863347
174pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.25822955
175pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.25348757
176ribonucleoprotein complex assembly (GO:0022618)2.22311782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.28310048
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.24736256
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87044987
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.44204934
5VDR_21846776_ChIP-Seq_THP-1_Human2.77798327
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64135381
7* XRN2_22483619_ChIP-Seq_HELA_Human2.35960028
8MYC_22102868_ChIP-Seq_BL_Human2.30895109
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30673656
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.29568531
11SRY_22984422_ChIP-ChIP_TESTIS_Rat2.28382717
12TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.25716699
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17671295
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.15188515
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15001605
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07159541
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04520340
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.03844213
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98508803
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.89666805
21DCP1A_22483619_ChIP-Seq_HELA_Human1.88011649
22CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87091826
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.83335435
24TTF2_22483619_ChIP-Seq_HELA_Human1.78742068
25VDR_24763502_ChIP-Seq_THP-1_Human1.75252797
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74910294
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72427624
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71739574
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.71082393
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.70981585
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70343493
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69331297
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65901453
34TCF7_22412390_ChIP-Seq_EML_Mouse1.65379374
35* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64602132
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.63048707
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62570385
38VDR_23849224_ChIP-Seq_CD4+_Human1.62539066
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57875867
40GATA1_22383799_ChIP-Seq_G1ME_Mouse1.57655372
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56480011
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54407146
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53251001
44MAF_26560356_Chip-Seq_TH1_Human1.52759035
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51606668
46FOXP3_21729870_ChIP-Seq_TREG_Human1.51508631
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50144446
48ZNF263_19887448_ChIP-Seq_K562_Human1.47618475
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.47213325
50* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47141093
51UTX_26944678_Chip-Seq_JUKART_Human1.45294770
52* GABP_19822575_ChIP-Seq_HepG2_Human1.45256282
53SCL_19346495_ChIP-Seq_HPC-7_Human1.44870951
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.44018425
55CIITA_25753668_ChIP-Seq_RAJI_Human1.42579310
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41331732
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40521416
58LXR_22292898_ChIP-Seq_THP-1_Human1.39259270
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38420884
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38100990
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37190580
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36719959
63MAF_26560356_Chip-Seq_TH2_Human1.36718882
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35805831
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35536495
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35232473
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.34656717
68KDM2B_26808549_Chip-Seq_DND41_Human1.34193560
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33733815
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32412356
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32188951
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31797803
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31744219
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31297000
75E2F1_21310950_ChIP-Seq_MCF-7_Human1.30785397
76* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30478296
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29433653
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28912094
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28607447
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28382183
81* SPI1_23547873_ChIP-Seq_NB4_Human1.27221730
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.26350271
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.25642698
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25608014
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25281838
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23330919
87KDM5A_27292631_Chip-Seq_BREAST_Human1.22714829
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21302993
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21120815
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20324554
91GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19912582
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19277280
93TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18805364
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15909220
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15768558
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15347250
97TFEB_21752829_ChIP-Seq_HELA_Human1.15187397
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13468068
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13104420
100* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12598403
101BCL6_27268052_Chip-Seq_Bcells_Human1.12453106
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.11153263
103THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09963812
104ELK1_22589737_ChIP-Seq_MCF10A_Human1.08824870
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08125362
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07840117
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07830504
108RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07256907
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06589245
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05541354
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04386164
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04180873
113* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02917060
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.02602871
115ATF3_27146783_Chip-Seq_COLON_Human1.01675335
116ELK1_19687146_ChIP-ChIP_HELA_Human1.01644484
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01588651
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00894385
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00613096
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00611290
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00384494
122MYB_26560356_Chip-Seq_TH2_Human1.00293695
123FOXP1_21924763_ChIP-Seq_HESCs_Human1.00178026
124CHD1_26751641_Chip-Seq_LNCaP_Human0.99590762
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99502469
126CTCF_21964334_Chip-Seq_Bcells_Human0.99502261
127STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99144870
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99034980
129* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98559082
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.98004407
131NCOR1_26117541_ChIP-Seq_K562_Human0.97854148
132RACK7_27058665_Chip-Seq_MCF-7_Human0.96321484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.23140649
2MP0003693_abnormal_embryo_hatching3.79528998
3MP0003183_abnormal_peptide_metabolism3.65623033
4MP0005451_abnormal_body_composition3.44404393
5MP0008260_abnormal_autophagy3.35483597
6MP0003806_abnormal_nucleotide_metabolis3.26920922
7MP0009379_abnormal_foot_pigmentation3.20310314
8MP0004957_abnormal_blastocyst_morpholog2.94146585
9MP0005058_abnormal_lysosome_morphology2.91845765
10MP0010352_gastrointestinal_tract_polyps2.74960281
11MP0002396_abnormal_hematopoietic_system2.62358821
12MP0003656_abnormal_erythrocyte_physiolo2.48550724
13MP0008058_abnormal_DNA_repair2.46713942
14MP0002132_abnormal_respiratory_system2.35618598
15MP0003191_abnormal_cellular_cholesterol2.24767741
16MP0005379_endocrine/exocrine_gland_phen2.20870148
17MP0000685_abnormal_immune_system2.19775026
18MP0003111_abnormal_nucleus_morphology2.19529521
19MP0003186_abnormal_redox_activity1.96746250
20MP0009333_abnormal_splenocyte_physiolog1.93036644
21MP0008932_abnormal_embryonic_tissue1.91867100
22MP0003567_abnormal_fetal_cardiomyocyte1.90266594
23MP0009278_abnormal_bone_marrow1.87315601
24MP0000490_abnormal_crypts_of1.80940703
25MP0006036_abnormal_mitochondrial_physio1.74256805
26MP0006035_abnormal_mitochondrial_morpho1.71598684
27MP0003436_decreased_susceptibility_to1.70225880
28MP0003303_peritoneal_inflammation1.65532406
29MP0002398_abnormal_bone_marrow1.64164704
30MP0003786_premature_aging1.63759642
31MP0001800_abnormal_humoral_immune1.62756697
32MP0002419_abnormal_innate_immunity1.61728311
33MP0003077_abnormal_cell_cycle1.60547853
34MP0001545_abnormal_hematopoietic_system1.58580882
35MP0005397_hematopoietic_system_phenotyp1.58580882
36MP0004808_abnormal_hematopoietic_stem1.57912869
37MP0002166_altered_tumor_susceptibility1.56134886
38MP0000703_abnormal_thymus_morphology1.55122721
39MP0003123_paternal_imprinting1.54674055
40MP0003866_abnormal_defecation1.49059546
41MP0001873_stomach_inflammation1.44234739
42MP0003763_abnormal_thymus_physiology1.43065763
43MP0001727_abnormal_embryo_implantation1.42074551
44MP0002277_abnormal_respiratory_mucosa1.40532317
45MP0003221_abnormal_cardiomyocyte_apopto1.37880245
46MP0001835_abnormal_antigen_presentation1.36697436
47MP0003724_increased_susceptibility_to1.35531342
48MP0000689_abnormal_spleen_morphology1.35272250
49MP0000750_abnormal_muscle_regeneration1.34711412
50MP0002452_abnormal_antigen_presenting1.33569571
51MP0003300_gastrointestinal_ulcer1.33478136
52MP0005083_abnormal_biliary_tract1.32331560
53MP0005174_abnormal_tail_pigmentation1.32206803
54MP0010030_abnormal_orbit_morphology1.30171341
55MP0002722_abnormal_immune_system1.30095824
56MP0008007_abnormal_cellular_replicative1.30022901
57MP0001790_abnormal_immune_system1.29299733
58MP0005387_immune_system_phenotype1.29299733
59MP0000678_abnormal_parathyroid_gland1.29155281
60MP0000358_abnormal_cell_content/1.28455617
61MP0002429_abnormal_blood_cell1.27576144
62MP0002420_abnormal_adaptive_immunity1.26019324
63MP0005076_abnormal_cell_differentiation1.25242395
64MP0010155_abnormal_intestine_physiology1.24177782
65MP0001819_abnormal_immune_cell1.23201391
66MP0008057_abnormal_DNA_replication1.22513906
67MP0004858_abnormal_nervous_system1.21765303
68MP0005000_abnormal_immune_tolerance1.20962204
69MP0001730_embryonic_growth_arrest1.20517176
70MP0000350_abnormal_cell_proliferation1.20438353
71MP0003828_pulmonary_edema1.20368112
72MP0000716_abnormal_immune_system1.17376265
73MP0000749_muscle_degeneration1.16219608
74MP0002405_respiratory_system_inflammati1.16165625
75MP0005501_abnormal_skin_physiology1.14145568
76MP0002723_abnormal_immune_serum1.13259680
77MP0000313_abnormal_cell_death1.11855493
78MP0001533_abnormal_skeleton_physiology1.10685187
79MP0002653_abnormal_ependyma_morphology1.10461758
80MP0006082_CNS_inflammation1.09961256
81MP0003075_altered_response_to1.09424312
82MP0005464_abnormal_platelet_physiology1.07624654
83MP0008469_abnormal_protein_level1.06672216
84MP0001697_abnormal_embryo_size1.06518661
85MP0005025_abnormal_response_to1.06241430
86MP0002080_prenatal_lethality1.04561890
87MP0002019_abnormal_tumor_incidence1.03952705
88MP0002148_abnormal_hypersensitivity_rea1.03711511
89MP0002210_abnormal_sex_determination1.02702961
90MP0003941_abnormal_skin_development1.02655767
91MP0009764_decreased_sensitivity_to1.02052862
92MP0009840_abnormal_foam_cell1.01433850
93MP0008789_abnormal_olfactory_epithelium1.01363502
94MP0003566_abnormal_cell_adhesion1.01128952
95MP0005670_abnormal_white_adipose1.00904900
96MP0004510_myositis1.00842495
97MP0010094_abnormal_chromosome_stability0.99772498
98MP0009785_altered_susceptibility_to0.95972804
99MP0003172_abnormal_lysosome_physiology0.95904896
100MP0002909_abnormal_adrenal_gland0.95470590
101MP0003315_abnormal_perineum_morphology0.95172243
102MP0004233_abnormal_muscle_weight0.94292714
103MP0000733_abnormal_muscle_development0.94075306
104MP0000477_abnormal_intestine_morphology0.93991800
105MP0003119_abnormal_digestive_system0.93000530
106MP0001845_abnormal_inflammatory_respons0.92733952
107MP0005623_abnormal_meninges_morphology0.91943596
108MP0005384_cellular_phenotype0.90676142
109MP0000858_altered_metastatic_potential0.90546205
110MP0005319_abnormal_enzyme/_coenzyme0.88953779
111MP0005671_abnormal_response_to0.88863839
112MP0000613_abnormal_salivary_gland0.88012393
113MP0001929_abnormal_gametogenesis0.86323028
114MP0002084_abnormal_developmental_patter0.86247465
115MP0002877_abnormal_melanocyte_morpholog0.85878345
116MP0002086_abnormal_extraembryonic_tissu0.85689961
117MP0005084_abnormal_gallbladder_morpholo0.85448943
118MP0003718_maternal_effect0.84573571
119MP0000465_gastrointestinal_hemorrhage0.82366955
120MP0006292_abnormal_olfactory_placode0.80618042
121MP0002234_abnormal_pharynx_morphology0.79993024
122MP0009765_abnormal_xenobiotic_induced0.79483563
123MP0002088_abnormal_embryonic_growth/wei0.79331152
124MP0008877_abnormal_DNA_methylation0.78989159
125MP0002085_abnormal_embryonic_tissue0.78277697
126MP0005330_cardiomyopathy0.77958070
127MP0004197_abnormal_fetal_growth/weight/0.76870822
128MP0000343_altered_response_to0.76616797
129MP0001672_abnormal_embryogenesis/_devel0.76485423
130MP0005380_embryogenesis_phenotype0.76485423
131MP0003984_embryonic_growth_retardation0.76170586
132MP0005257_abnormal_intraocular_pressure0.75834248
133MP0010630_abnormal_cardiac_muscle0.75360425
134MP0005410_abnormal_fertilization0.74947590
135MP0005165_increased_susceptibility_to0.74849913
136MP0000751_myopathy0.73941222
137MP0001853_heart_inflammation0.73578035
138MP0001145_abnormal_male_reproductive0.73004591
139MP0002796_impaired_skin_barrier0.72498600
140MP0004947_skin_inflammation0.71400382
141MP0009931_abnormal_skin_appearance0.70950080
142MP0002006_tumorigenesis0.68695559
143MP0005023_abnormal_wound_healing0.67571663
144MP0002282_abnormal_trachea_morphology0.66790026

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.82682302
2Abnormality of cells of the erythroid lineage (HP:0012130)6.52180625
3Abnormal number of erythroid precursors (HP:0012131)5.88310993
4Macrocytic anemia (HP:0001972)4.94587829
5Carpal bone hypoplasia (HP:0001498)4.70358234
6Pallor (HP:0000980)4.50838586
7J-shaped sella turcica (HP:0002680)4.49509057
8Abnormal hemoglobin (HP:0011902)3.87925932
9Recurrent bronchitis (HP:0002837)3.83447342
10Flat acetabular roof (HP:0003180)3.69669920
11Ragged-red muscle fibers (HP:0003200)3.66485005
12Diastasis recti (HP:0001540)3.61531055
13Abnormality of macrophages (HP:0004311)3.61002766
14Thoracolumbar scoliosis (HP:0002944)3.42410615
15Microvesicular hepatic steatosis (HP:0001414)3.39402777
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.39206284
17Abnormality of glycolipid metabolism (HP:0010969)3.31170176
18Abnormality of liposaccharide metabolism (HP:0010968)3.31170176
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.31170176
20Broad alveolar ridges (HP:0000187)3.28666819
21Thrombocytosis (HP:0001894)3.27134549
22Vertebral arch anomaly (HP:0008438)3.25539125
23Rough bone trabeculation (HP:0100670)3.13203819
24Abnormality of reticulocytes (HP:0004312)3.04990444
25Microretrognathia (HP:0000308)3.00281057
26Concave nail (HP:0001598)2.97998007
27Degeneration of anterior horn cells (HP:0002398)2.94415295
28Abnormality of the anterior horn cell (HP:0006802)2.94415295
29Acute encephalopathy (HP:0006846)2.89780827
30Recurrent abscess formation (HP:0002722)2.88275149
31Beaking of vertebral bodies (HP:0004568)2.82385032
32Increased serum pyruvate (HP:0003542)2.81466892
33Upper limb muscle weakness (HP:0003484)2.80743021
34Hepatic necrosis (HP:0002605)2.77792060
35Achilles tendon contracture (HP:0001771)2.77567947
36Increased CSF lactate (HP:0002490)2.77469100
37Deformed sella turcica (HP:0002681)2.76828856
38Type I transferrin isoform profile (HP:0003642)2.76482025
39Abnormality of glycolysis (HP:0004366)2.75330352
40Exercise intolerance (HP:0003546)2.73744568
41Dysostosis multiplex (HP:0000943)2.69732248
42Aplastic anemia (HP:0001915)2.66505135
43Flared iliac wings (HP:0002869)2.64253879
44Rectal prolapse (HP:0002035)2.62995304
45Abnormal gallbladder physiology (HP:0012438)2.62870742
46Cholecystitis (HP:0001082)2.62870742
47Amyloidosis (HP:0011034)2.60199504
48Mucopolysacchariduria (HP:0008155)2.58042857
49Urinary glycosaminoglycan excretion (HP:0003541)2.58042857
50Recurrent bacterial skin infections (HP:0005406)2.53512926
51Multiple enchondromatosis (HP:0005701)2.50133389
52Lactic acidosis (HP:0003128)2.49575490
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.47238125
54Abnormal protein N-linked glycosylation (HP:0012347)2.47238125
55Abnormal protein glycosylation (HP:0012346)2.47238125
56Abnormal glycosylation (HP:0012345)2.47238125
57Rhabdomyolysis (HP:0003201)2.42472111
58Increased intramyocellular lipid droplets (HP:0012240)2.41164755
59Increased serum lactate (HP:0002151)2.40545065
60Abnormal trabecular bone morphology (HP:0100671)2.39497772
61Abnormality of the sella turcica (HP:0002679)2.39373537
62Nasal polyposis (HP:0100582)2.39297175
63Progressive external ophthalmoplegia (HP:0000590)2.38985659
64Progressive macrocephaly (HP:0004481)2.38118649
65Abnormality of the Achilles tendon (HP:0005109)2.35629668
66Abnormality of the nasal mucosa (HP:0000433)2.35611486
67Abnormality of the lumbar spine (HP:0100712)2.33868967
68Prolonged neonatal jaundice (HP:0006579)2.32232129
69Thickened calvaria (HP:0002684)2.30373699
70Broad ribs (HP:0000885)2.29424037
71Thoracic kyphosis (HP:0002942)2.29207787
72Distal lower limb muscle weakness (HP:0009053)2.28028656
73Short nail (HP:0001799)2.27859090
74Respiratory difficulties (HP:0002880)2.26769908
75Vertebral compression fractures (HP:0002953)2.25767526
76Loss of speech (HP:0002371)2.25487286
77Poikiloderma (HP:0001029)2.23163157
78Hand muscle atrophy (HP:0009130)2.22823260
79Trismus (HP:0000211)2.22082810
80Eczematoid dermatitis (HP:0000976)2.21456036
81Pustule (HP:0200039)2.21013834
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20949354
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20893570
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20893570
85Elevated erythrocyte sedimentation rate (HP:0003565)2.20315950
86Gastrointestinal inflammation (HP:0004386)2.19652530
87Bronchitis (HP:0012387)2.19535565
88IgM deficiency (HP:0002850)2.19280372
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.18722013
90Seborrheic dermatitis (HP:0001051)2.18553333
91Premature ovarian failure (HP:0008209)2.18552824
92Increased muscle lipid content (HP:0009058)2.17939262
93Vacuolated lymphocytes (HP:0001922)2.16912824
94Cerebral edema (HP:0002181)2.15140777
95Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14977486
96Abnormality of polysaccharide metabolism (HP:0011012)2.14977486
97Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14977486
98Impaired platelet aggregation (HP:0003540)2.14929731
99Abnormal platelet function (HP:0011869)2.14929731
100Inflammation of the large intestine (HP:0002037)2.14107998
101Reduced antithrombin III activity (HP:0001976)2.13430720
102Entropion (HP:0000621)2.11888043
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09377420
104Progressive neurologic deterioration (HP:0002344)2.08978147
1053-Methylglutaconic aciduria (HP:0003535)2.07889725
106Hypertensive crisis (HP:0100735)2.07493393
107Hepatosplenomegaly (HP:0001433)2.07298592
108Urticaria (HP:0001025)2.06650784
109Deep palmar crease (HP:0006191)2.05753344
110Prolonged bleeding time (HP:0003010)2.04385119
111Myopathic facies (HP:0002058)2.04090487
112Abnormality of the thoracic spine (HP:0100711)2.01902907
113Increased IgM level (HP:0003496)2.01798361
114Cavernous hemangioma (HP:0001048)2.01106299
115Mediastinal lymphadenopathy (HP:0100721)2.00929495
116Cerebral aneurysm (HP:0004944)2.00296691
117Hoarse voice (HP:0001609)1.99684843
118Megalocornea (HP:0000485)1.98889927
119Colitis (HP:0002583)1.98275114
120Abnormal pupillary function (HP:0007686)1.97712911
121Hypokinesia (HP:0002375)1.97145923
122Increased serum ferritin (HP:0003281)1.96950961
123Fasciculations (HP:0002380)1.95541105
124Fatigue (HP:0012378)1.94843533
125Distal upper limb amyotrophy (HP:0007149)1.94710527
126Upper limb amyotrophy (HP:0009129)1.94710527
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.94147451
12811 pairs of ribs (HP:0000878)1.93514652
129Papilloma (HP:0012740)1.92183146
130Verrucae (HP:0200043)1.92183146
131Acute necrotizing encephalopathy (HP:0006965)1.91641600
132Upper motor neuron abnormality (HP:0002127)1.91605084
133Recurrent gram-negative bacterial infections (HP:0005420)1.91314976
134Secondary amenorrhea (HP:0000869)1.90233110
135Aplasia/Hypoplasia of the scapulae (HP:0006713)1.87666117
136Hypoplastic scapulae (HP:0000882)1.87666117
137Thick lower lip vermilion (HP:0000179)1.85320313
138Down-sloping shoulders (HP:0200021)1.84638630
139Death in infancy (HP:0001522)1.84637640
140Exertional dyspnea (HP:0002875)1.84582144
141Axonal loss (HP:0003447)1.83304562
142Emotional lability (HP:0000712)1.82989690
143Broad distal phalanx of finger (HP:0009836)1.82539284
144Increased connective tissue (HP:0009025)1.82147658
145Testicular atrophy (HP:0000029)1.81827417
146Spinal cord compression (HP:0002176)1.81643087
147Abnormal neuron morphology (HP:0012757)1.81618342
148Abnormality of the motor neurons (HP:0002450)1.81618342
149Abnormality of the distal phalanges of the toes (HP:0010182)1.81571968
150Hypoplasia of the odontoid process (HP:0003311)1.81215229
151Diaphragmatic weakness (HP:0009113)1.81090832
152Respiratory failure (HP:0002878)1.80553304
153Obstructive lung disease (HP:0006536)1.80541065
154Chronic obstructive pulmonary disease (HP:0006510)1.80541065
155Abnormality of the alveolar ridges (HP:0006477)1.80001077
156Basal cell carcinoma (HP:0002671)1.79821677
157Aortic regurgitation (HP:0001659)1.79512119
158Sparse eyelashes (HP:0000653)1.79195356
159Abnormality of the tricuspid valve (HP:0001702)1.78895114
160Depressed nasal ridge (HP:0000457)1.78197171
161Asplenia (HP:0001746)1.76932280
162Progressive muscle weakness (HP:0003323)1.75763271
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74367489
164Abnormal mitochondria in muscle tissue (HP:0008316)1.74065092
165Mitochondrial inheritance (HP:0001427)1.72535101
166Petechiae (HP:0000967)1.71224274
167Missing ribs (HP:0000921)1.69899349
168Hepatocellular necrosis (HP:0001404)1.69819887
169Myositis (HP:0100614)1.69307464
170Absent thumb (HP:0009777)1.68783702
171Elbow flexion contracture (HP:0002987)1.68415752
172Migraine (HP:0002076)1.68325200
173Protuberant abdomen (HP:0001538)1.65953456
174Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.65742264
175Panhypogammaglobulinemia (HP:0003139)1.65583739
176Chin dimple (HP:0010751)1.63467515
177Increased density of long bones (HP:0006392)1.62990457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.61542941
2VRK23.92247188
3TLK13.83692264
4MAP4K13.36626813
5TRIB32.97378164
6TESK12.91106229
7BCKDK2.75087816
8EPHA22.68614860
9STK162.63284052
10EEF2K2.59729124
11MAP3K102.56901040
12ERN12.34835515
13ARAF2.19522365
14MST1R2.12200753
15LIMK12.11533679
16DYRK32.02088587
17PKN21.94591794
18ICK1.90526073
19PIM21.86119696
20LRRK21.74009464
21TAOK21.72561359
22SRPK11.65479557
23NEK21.57975843
24SIK31.57501082
25RPS6KA41.51635597
26LMTK21.50844069
27RPS6KB21.43686800
28SMG11.40802470
29PBK1.40041294
30NME11.39837288
31GRK61.39302215
32MAP3K111.38266133
33MAP2K21.36151405
34ZAP701.26964537
35PDK21.25112499
36EPHB11.24296321
37EIF2AK11.24014175
38ABL21.21910587
39BUB11.20425610
40WEE11.19253124
41STK101.16056626
42TBK11.15624241
43CDC71.14267632
44TYK21.10404366
45CDK41.08610479
46CSF1R1.06882474
47MAP3K31.06411563
48MAPKAPK31.04455098
49FLT31.03985126
50BRAF1.03080456
51ILK1.03023819
52MAP3K81.01001237
53FES0.99340844
54SIK10.98532177
55MET0.97209427
56MAPKAPK50.96699482
57BTK0.95991915
58BLK0.94960764
59PAK40.94046375
60MST40.92555653
61DYRK1B0.92329636
62CSK0.92264872
63KIT0.91346475
64IKBKB0.90353804
65PIM10.90212500
66DAPK10.87888899
67MATK0.87869421
68PRPF4B0.87681228
69TAOK10.87188977
70CDK190.86620226
71DAPK30.85553926
72CDK70.85208732
73MAP2K30.84609064
74DMPK0.84515203
75PRKD20.82585468
76TEC0.82179890
77TGFBR10.78527758
78ALK0.77689109
79IRAK30.77644522
80SCYL20.76701193
81MAPK150.76028361
82PAK10.75608333
83RPS6KA50.74292797
84STK240.73307699
85AURKA0.71452630
86FGR0.71120955
87NEK10.71106801
88RPS6KC10.70898888
89RPS6KL10.70898888
90MAPK110.70744919
91RAF10.70040369
92HCK0.69907330
93TESK20.69647330
94RIPK40.67379126
95SYK0.65742668
96ERBB40.65277991
97RPS6KA60.64544185
98BMX0.64289590
99PRKCI0.63849107
100IRAK20.63664113
101PTK20.63649548
102PTK60.63362121
103VRK10.62760137
104TAOK30.62702793
105MAPKAPK20.62509799
106LCK0.62473352
107PRKG20.61836680
108TYRO30.61246573
109RPS6KA10.60712622
110TTN0.58578218
111PLK40.58383332
112AURKB0.58031262
113SIK20.57250010
114CDK80.56868379
115PAK20.56666273
116KDR0.56545097
117MAP3K10.56267511
118HIPK20.55259129
119MAP3K50.54705574
120TGFBR20.53903002
121IRAK40.52871011
122MARK30.51748284
123MAP2K60.50966202
124CDK90.50154761
125CDK60.50074112
126MOS0.48334653
127RET0.48268916
128BRSK20.47401418
129MAPK40.47378456
130IRAK10.47111076
131IKBKE0.46711117
132PDGFRA0.46150478
133CSNK1G30.45681424
134TTK0.45623891
135CDK140.45463944
136LYN0.44767989
137CLK10.44249041
138CAMK2D0.43973453
139CDK11A0.43474033
140PLK10.42873888
141BRSK10.42146770
142RPS6KA20.40302777
143CSNK2A20.40105387
144MAP3K120.39870581
145CSNK2A10.39386121
146CHEK10.35684011
147ATR0.35150501
148CDK150.31724947
149CDK180.31561297
150AKT20.31527871
151MAP2K70.25804331

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.36296599
2DNA replication_Homo sapiens_hsa030303.18397010
3Spliceosome_Homo sapiens_hsa030402.70208486
4Homologous recombination_Homo sapiens_hsa034402.69320721
5Parkinsons disease_Homo sapiens_hsa050122.05102369
6Mismatch repair_Homo sapiens_hsa034301.98712579
7Base excision repair_Homo sapiens_hsa034101.88114086
8Oxidative phosphorylation_Homo sapiens_hsa001901.80507983
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76569720
10Pyrimidine metabolism_Homo sapiens_hsa002401.71994977
11Nucleotide excision repair_Homo sapiens_hsa034201.61854223
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59699160
13Fatty acid elongation_Homo sapiens_hsa000621.58108384
14RNA transport_Homo sapiens_hsa030131.57032184
15B cell receptor signaling pathway_Homo sapiens_hsa046621.53146206
16Sulfur relay system_Homo sapiens_hsa041221.51249305
17RNA polymerase_Homo sapiens_hsa030201.51158879
18Thyroid cancer_Homo sapiens_hsa052161.44132198
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42951466
20Antigen processing and presentation_Homo sapiens_hsa046121.42790103
21Biosynthesis of amino acids_Homo sapiens_hsa012301.39010520
22Alzheimers disease_Homo sapiens_hsa050101.37724324
23Galactose metabolism_Homo sapiens_hsa000521.37125365
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34109706
25Systemic lupus erythematosus_Homo sapiens_hsa053221.32950822
26Huntingtons disease_Homo sapiens_hsa050161.29185491
27Bladder cancer_Homo sapiens_hsa052191.26936271
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25208260
29Acute myeloid leukemia_Homo sapiens_hsa052211.24656228
30Carbon metabolism_Homo sapiens_hsa012001.21017312
31Chronic myeloid leukemia_Homo sapiens_hsa052201.20102492
32Primary immunodeficiency_Homo sapiens_hsa053401.19136032
33Cell cycle_Homo sapiens_hsa041101.18351816
34Glutathione metabolism_Homo sapiens_hsa004801.16836683
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15833993
36Vibrio cholerae infection_Homo sapiens_hsa051101.14115822
37Fructose and mannose metabolism_Homo sapiens_hsa000511.13943096
38Protein export_Homo sapiens_hsa030601.12142599
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10831517
40mRNA surveillance pathway_Homo sapiens_hsa030151.07428327
41VEGF signaling pathway_Homo sapiens_hsa043701.06082872
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03027292
43Lysosome_Homo sapiens_hsa041421.01280622
44Proteasome_Homo sapiens_hsa030501.00537905
45Herpes simplex infection_Homo sapiens_hsa051680.99146431
46One carbon pool by folate_Homo sapiens_hsa006700.98029814
47Shigellosis_Homo sapiens_hsa051310.97759558
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97346349
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96338717
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94103134
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91457862
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87539532
53Hematopoietic cell lineage_Homo sapiens_hsa046400.87199206
54Purine metabolism_Homo sapiens_hsa002300.86123303
55T cell receptor signaling pathway_Homo sapiens_hsa046600.85174878
56Leishmaniasis_Homo sapiens_hsa051400.84168013
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.82695945
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81941184
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81565526
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81499208
61HTLV-I infection_Homo sapiens_hsa051660.80442441
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80426589
63Osteoclast differentiation_Homo sapiens_hsa043800.79832667
64Viral myocarditis_Homo sapiens_hsa054160.79763772
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79297219
66Viral carcinogenesis_Homo sapiens_hsa052030.78138392
67Apoptosis_Homo sapiens_hsa042100.78136615
68Basal transcription factors_Homo sapiens_hsa030220.77526243
69Alcoholism_Homo sapiens_hsa050340.76612194
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76475702
71Pyruvate metabolism_Homo sapiens_hsa006200.76466951
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76395907
73Epstein-Barr virus infection_Homo sapiens_hsa051690.74516668
74Phagosome_Homo sapiens_hsa041450.74135281
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74004865
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.73840130
77p53 signaling pathway_Homo sapiens_hsa041150.73788938
78Platelet activation_Homo sapiens_hsa046110.72575380
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71344047
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.70764769
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69564561
82Hepatitis B_Homo sapiens_hsa051610.69174521
83Non-small cell lung cancer_Homo sapiens_hsa052230.68957677
84Steroid biosynthesis_Homo sapiens_hsa001000.68947897
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67352425
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67178086
87Fanconi anemia pathway_Homo sapiens_hsa034600.67104517
88Measles_Homo sapiens_hsa051620.66968029
89Endocytosis_Homo sapiens_hsa041440.66426037
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.64205443
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.60073089
92Proteoglycans in cancer_Homo sapiens_hsa052050.59965276
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58852319
94RNA degradation_Homo sapiens_hsa030180.58362685
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57822250
96Small cell lung cancer_Homo sapiens_hsa052220.57444639
97Notch signaling pathway_Homo sapiens_hsa043300.57115862
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56677870
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.56520110
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56211985
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.55769642
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55587761
103Toxoplasmosis_Homo sapiens_hsa051450.55006598
104Pancreatic cancer_Homo sapiens_hsa052120.54268646
105Collecting duct acid secretion_Homo sapiens_hsa049660.54141002
106Legionellosis_Homo sapiens_hsa051340.53500746
107Other glycan degradation_Homo sapiens_hsa005110.52441260
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52287352
109Influenza A_Homo sapiens_hsa051640.51455933
110Cardiac muscle contraction_Homo sapiens_hsa042600.50887269
111Metabolic pathways_Homo sapiens_hsa011000.49253344
112N-Glycan biosynthesis_Homo sapiens_hsa005100.48348864
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.47679155
114Salmonella infection_Homo sapiens_hsa051320.46809091
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46490389
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45070968
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.44766456
118Malaria_Homo sapiens_hsa051440.44731616
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44165928
120Oocyte meiosis_Homo sapiens_hsa041140.44064298
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43132603
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42771057
123Prostate cancer_Homo sapiens_hsa052150.42118052
124Folate biosynthesis_Homo sapiens_hsa007900.42112767
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42077685
126Phenylalanine metabolism_Homo sapiens_hsa003600.41751117
127Pentose phosphate pathway_Homo sapiens_hsa000300.39225016
128Non-homologous end-joining_Homo sapiens_hsa034500.38977258
129Glioma_Homo sapiens_hsa052140.38154730
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37646460
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37597165
132Tuberculosis_Homo sapiens_hsa051520.37004424
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35217906

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