DNTTIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)5.03014126
2mitotic metaphase plate congression (GO:0007080)4.63756199
3nuclear pore organization (GO:0006999)4.57428251
4DNA double-strand break processing (GO:0000729)4.38002520
5nuclear pore complex assembly (GO:0051292)4.31301287
6nucleobase biosynthetic process (GO:0046112)4.28711436
7purine nucleobase biosynthetic process (GO:0009113)4.23676745
8DNA replication checkpoint (GO:0000076)4.13948832
9formation of translation preinitiation complex (GO:0001731)4.13029045
10DNA replication initiation (GO:0006270)4.11621261
11maturation of SSU-rRNA (GO:0030490)4.07233667
12metaphase plate congression (GO:0051310)4.07192611
13mitotic nuclear envelope disassembly (GO:0007077)4.02776602
14DNA strand elongation involved in DNA replication (GO:0006271)4.01724152
15ribosome biogenesis (GO:0042254)4.01417002
16kinetochore organization (GO:0051383)3.96609459
17protein localization to kinetochore (GO:0034501)3.95802792
18CENP-A containing nucleosome assembly (GO:0034080)3.90626580
19chromatin remodeling at centromere (GO:0031055)3.89383411
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.86120307
21DNA strand elongation (GO:0022616)3.82175660
22replication fork processing (GO:0031297)3.80009296
23RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.76561568
24regulation of spindle organization (GO:0090224)3.75155143
25IMP biosynthetic process (GO:0006188)3.72929979
26membrane disassembly (GO:0030397)3.70982396
27nuclear envelope disassembly (GO:0051081)3.70982396
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65313635
29telomere maintenance via semi-conservative replication (GO:0032201)3.65299502
30ribonucleoprotein complex biogenesis (GO:0022613)3.64459458
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62773404
32regulation of mitotic spindle checkpoint (GO:1903504)3.62773404
33somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.62160173
34isotype switching (GO:0045190)3.62160173
35somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.62160173
36attachment of spindle microtubules to kinetochore (GO:0008608)3.59283590
37establishment of chromosome localization (GO:0051303)3.58932923
38pore complex assembly (GO:0046931)3.58668642
39kinetochore assembly (GO:0051382)3.58469334
40ribosomal large subunit biogenesis (GO:0042273)3.57935949
41DNA unwinding involved in DNA replication (GO:0006268)3.57063481
42monoubiquitinated protein deubiquitination (GO:0035520)3.56154437
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54529321
44DNA catabolic process, exonucleolytic (GO:0000738)3.54401193
45DNA replication-dependent nucleosome organization (GO:0034723)3.53680552
46DNA replication-dependent nucleosome assembly (GO:0006335)3.53680552
47telomere maintenance via recombination (GO:0000722)3.53186912
48DNA replication-independent nucleosome organization (GO:0034724)3.52871548
49DNA replication-independent nucleosome assembly (GO:0006336)3.52871548
50pseudouridine synthesis (GO:0001522)3.48249488
51spindle checkpoint (GO:0031577)3.44657436
52cullin deneddylation (GO:0010388)3.44626808
53proteasome assembly (GO:0043248)3.43290199
54mitotic chromosome condensation (GO:0007076)3.42246961
55recombinational repair (GO:0000725)3.40854905
56double-strand break repair via homologous recombination (GO:0000724)3.40789089
57mitotic recombination (GO:0006312)3.40078874
58protein K6-linked ubiquitination (GO:0085020)3.39672601
59histone exchange (GO:0043486)3.36743898
60ribosomal small subunit assembly (GO:0000028)3.35516106
61mitotic spindle checkpoint (GO:0071174)3.34372509
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33765094
63negative regulation of sister chromatid segregation (GO:0033046)3.33765094
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.33765094
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33765094
66rRNA processing (GO:0006364)3.33492685
67negative regulation of chromosome segregation (GO:0051985)3.33064692
68IMP metabolic process (GO:0046040)3.31715669
69telomere maintenance via telomere lengthening (GO:0010833)3.30757795
70positive regulation of chromosome segregation (GO:0051984)3.29773422
71mitotic spindle assembly checkpoint (GO:0007094)3.29662750
72spindle assembly checkpoint (GO:0071173)3.29648277
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28933439
74meiotic chromosome segregation (GO:0045132)3.28892609
75respiratory chain complex IV assembly (GO:0008535)3.28469027
76maturation of 5.8S rRNA (GO:0000460)3.27846698
77rRNA methylation (GO:0031167)3.27019883
78protein localization to chromosome, centromeric region (GO:0071459)3.26754915
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26753316
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26441669
81signal peptide processing (GO:0006465)3.26296272
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25972873
83spliceosomal snRNP assembly (GO:0000387)3.25713447
84regulation of mitotic spindle organization (GO:0060236)3.25172977
85mitochondrial RNA metabolic process (GO:0000959)3.23166360
86rRNA metabolic process (GO:0016072)3.22008216
87termination of RNA polymerase I transcription (GO:0006363)3.21772175
88regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20891413
89DNA deamination (GO:0045006)3.20855795
90response to X-ray (GO:0010165)3.20452033
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19151564
92transcription elongation from RNA polymerase I promoter (GO:0006362)3.18526514
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18494076
94rRNA modification (GO:0000154)3.18258047
95regulation of chromosome segregation (GO:0051983)3.17217031
96postreplication repair (GO:0006301)3.15085105
97establishment of protein localization to mitochondrial membrane (GO:0090151)3.14481414
98histone mRNA metabolic process (GO:0008334)3.14053917
99protein deneddylation (GO:0000338)3.13629299
100regulation of centrosome cycle (GO:0046605)3.12479940
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11762177
102negative regulation of DNA recombination (GO:0045910)3.10228629
103mitotic sister chromatid segregation (GO:0000070)3.10090856
104transcription from RNA polymerase I promoter (GO:0006360)3.09616599
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09525471
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07948356
107transcription-coupled nucleotide-excision repair (GO:0006283)3.07621156
108regulation of sister chromatid segregation (GO:0033045)3.07602515
109regulation of mitotic sister chromatid separation (GO:0010965)3.07602515
110regulation of mitotic sister chromatid segregation (GO:0033047)3.07602515
111regulation of DNA endoreduplication (GO:0032875)3.07358731
112regulation of helicase activity (GO:0051095)3.07143356
113non-recombinational repair (GO:0000726)3.05448202
114double-strand break repair via nonhomologous end joining (GO:0006303)3.05448202
115nucleotide-excision repair, DNA gap filling (GO:0006297)3.04437810
1167-methylguanosine mRNA capping (GO:0006370)3.01036239
117mitotic sister chromatid cohesion (GO:0007064)3.01027779
118negative regulation of ligase activity (GO:0051352)3.00367755
119negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.00367755
1207-methylguanosine RNA capping (GO:0009452)2.99717549
121RNA capping (GO:0036260)2.99717549
122transcription initiation from RNA polymerase I promoter (GO:0006361)2.98880196
123termination of RNA polymerase III transcription (GO:0006386)2.97013958
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.97013958
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.96686652
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.95517575
127somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95517575
128spliceosomal complex assembly (GO:0000245)2.95204551
129mitochondrial respiratory chain complex assembly (GO:0033108)2.95141953
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.94397644
131somatic recombination of immunoglobulin gene segments (GO:0016447)2.91374968
132regulation of centriole replication (GO:0046599)2.90431511
133synapsis (GO:0007129)2.90220996
134cell cycle G1/S phase transition (GO:0044843)2.89386664
135G1/S transition of mitotic cell cycle (GO:0000082)2.89386664
136folic acid-containing compound biosynthetic process (GO:0009396)2.87951380
137protein neddylation (GO:0045116)2.87361647
138telomere maintenance via telomerase (GO:0007004)2.86587020
139somatic diversification of immunoglobulins (GO:0016445)2.86066531
140ribosomal small subunit biogenesis (GO:0042274)2.85190943
141mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84115116
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.84115116
143NADH dehydrogenase complex assembly (GO:0010257)2.84115116
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.83539857
145RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.83539857
146cytochrome complex assembly (GO:0017004)2.82900194
147centriole replication (GO:0007099)2.82522586
148protein complex biogenesis (GO:0070271)2.82076776
149transcription from mitochondrial promoter (GO:0006390)2.81467226
150tRNA processing (GO:0008033)2.80468783
151histone H2A acetylation (GO:0043968)2.79644454
152regulation of meiosis I (GO:0060631)2.77025488
153signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76203419
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76203419
155signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76203419
156positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74666648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.20382964
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.31485901
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.81135115
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79057976
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35918361
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.24665017
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14298618
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.07796956
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.00905686
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98047758
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88053483
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.83482591
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81364969
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75624903
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68779211
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60168823
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.58429948
18VDR_22108803_ChIP-Seq_LS180_Human2.57706360
19ZNF274_21170338_ChIP-Seq_K562_Hela2.56747495
20AR_21909140_ChIP-Seq_LNCAP_Human2.49074980
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47230778
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46143863
23* VDR_23849224_ChIP-Seq_CD4+_Human2.38249080
24EWS_26573619_Chip-Seq_HEK293_Human2.33471707
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29810106
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22686840
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.22626927
28* XRN2_22483619_ChIP-Seq_HELA_Human2.21045950
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11464896
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07948867
31FUS_26573619_Chip-Seq_HEK293_Human2.05729430
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03335854
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99910583
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.99756468
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.96802161
36FOXP3_21729870_ChIP-Seq_TREG_Human1.95990377
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.95588035
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93474137
39* DCP1A_22483619_ChIP-Seq_HELA_Human1.93376110
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91679937
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87501253
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84576471
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81327427
44TAF15_26573619_Chip-Seq_HEK293_Human1.81144318
45* TTF2_22483619_ChIP-Seq_HELA_Human1.81114766
46* GABP_19822575_ChIP-Seq_HepG2_Human1.80044900
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.78731258
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77553517
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75249634
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73277958
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71719801
52IGF1R_20145208_ChIP-Seq_DFB_Human1.69757630
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64183610
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59097723
55P300_19829295_ChIP-Seq_ESCs_Human1.56991365
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54375323
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53010046
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48815071
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45070591
60KDM5A_27292631_Chip-Seq_BREAST_Human1.44770971
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44201587
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42169676
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.40148618
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.38551365
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37685832
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36449916
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35516586
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34258933
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.33705894
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33222465
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33220351
72GBX2_23144817_ChIP-Seq_PC3_Human1.31546449
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31009574
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30065782
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29335155
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29335155
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29335155
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.28152925
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27333328
80CIITA_25753668_ChIP-Seq_RAJI_Human1.27114474
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.24890271
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24149542
83IRF1_19129219_ChIP-ChIP_H3396_Human1.23430563
84* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22898337
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.21843081
86* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21289994
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20637617
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20570676
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20292241
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20232316
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.20079800
92ER_23166858_ChIP-Seq_MCF-7_Human1.19883114
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17868471
94TFEB_21752829_ChIP-Seq_HELA_Human1.14810053
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14272077
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13363044
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13256879
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12951019
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.12097636
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11920072
101CBP_20019798_ChIP-Seq_JUKART_Human1.11207224
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11207224
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11000457
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10880035
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09887698
106TP53_22573176_ChIP-Seq_HFKS_Human1.07715158
107RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06777552
108* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06573824
109MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05960160
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04397062
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.03359279
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03059723
113* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02649399
114TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02140179
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01406579
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01152991
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.00635213
118* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99752998
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99591647
120* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99431748
121MYC_22102868_ChIP-Seq_BL_Human0.98321129
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97522435
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96514421
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96015645
125* MYC_18940864_ChIP-ChIP_HL60_Human0.95630762
126BCAT_22108803_ChIP-Seq_LS180_Human0.95232757
127FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95016393
128FOXA1_25329375_ChIP-Seq_VCAP_Human0.95016393
129* NANOG_19829295_ChIP-Seq_ESCs_Human0.94630768
130* SOX2_19829295_ChIP-Seq_ESCs_Human0.94630768
131KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93809552
132* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92941088
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92907104
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92177649
135SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92077957
136TCF4_22108803_ChIP-Seq_LS180_Human0.91134900
137STAT3_23295773_ChIP-Seq_U87_Human0.90210598
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88531234
139P300_18555785_Chip-Seq_ESCs_Mouse0.88128794
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87613887
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86704026
142CDX2_22108803_ChIP-Seq_LS180_Human0.86595445
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86000015
144* SPI1_23547873_ChIP-Seq_NB4_Human0.84515899
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.83302882
146NANOG_21062744_ChIP-ChIP_HESCs_Human0.82153216
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82147397
148* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81939328
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79544609
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78478763
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77025997
152CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75290448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.56063506
2MP0010094_abnormal_chromosome_stability4.56343983
3MP0003111_abnormal_nucleus_morphology4.31568703
4MP0004957_abnormal_blastocyst_morpholog4.28123541
5MP0008057_abnormal_DNA_replication4.12288618
6MP0003077_abnormal_cell_cycle3.98174901
7MP0000569_abnormal_digit_pigmentation3.70623566
8MP0008058_abnormal_DNA_repair3.57268089
9MP0008877_abnormal_DNA_methylation3.22301439
10MP0008007_abnormal_cellular_replicative3.02526544
11MP0002102_abnormal_ear_morphology2.63033848
12MP0008932_abnormal_embryonic_tissue2.60621312
13MP0001730_embryonic_growth_arrest2.44510202
14MP0003718_maternal_effect2.32599145
15MP0003786_premature_aging2.30685725
16MP0003123_paternal_imprinting2.28742105
17MP0002396_abnormal_hematopoietic_system2.21701138
18MP0000350_abnormal_cell_proliferation2.20256232
19MP0010307_abnormal_tumor_latency1.98256646
20MP0010352_gastrointestinal_tract_polyps1.95398876
21MP0003195_calcinosis1.88936633
22MP0006072_abnormal_retinal_apoptosis1.87920189
23MP0001672_abnormal_embryogenesis/_devel1.74013617
24MP0005380_embryogenesis_phenotype1.74013617
25MP0001697_abnormal_embryo_size1.68373540
26MP0006035_abnormal_mitochondrial_morpho1.68285985
27MP0006036_abnormal_mitochondrial_physio1.64439516
28MP0003646_muscle_fatigue1.61287864
29MP0003806_abnormal_nucleotide_metabolis1.60637535
30MP0003984_embryonic_growth_retardation1.55164260
31MP0002736_abnormal_nociception_after1.51481193
32MP0002088_abnormal_embryonic_growth/wei1.50511258
33MP0002080_prenatal_lethality1.47890160
34MP0002210_abnormal_sex_determination1.46585465
35MP0000490_abnormal_crypts_of1.44467586
36MP0002085_abnormal_embryonic_tissue1.44136438
37MP0004147_increased_porphyrin_level1.42015244
38MP0003567_abnormal_fetal_cardiomyocyte1.41801044
39MP0002837_dystrophic_cardiac_calcinosis1.40436930
40MP0005253_abnormal_eye_physiology1.39099729
41MP0009333_abnormal_splenocyte_physiolog1.38615938
42MP0000313_abnormal_cell_death1.36901878
43MP0002084_abnormal_developmental_patter1.36692438
44MP0000427_abnormal_hair_cycle1.36687750
45MP0002086_abnormal_extraembryonic_tissu1.36645693
46MP0000372_irregular_coat_pigmentation1.33062707
47MP0004197_abnormal_fetal_growth/weight/1.32034352
48MP0004215_abnormal_myocardial_fiber1.31662374
49MP0003121_genomic_imprinting1.31273105
50MP0002019_abnormal_tumor_incidence1.29343465
51MP0005551_abnormal_eye_electrophysiolog1.29043823
52MP0004808_abnormal_hematopoietic_stem1.27207216
53MP0003950_abnormal_plasma_membrane1.25642102
54MP0003890_abnormal_embryonic-extraembry1.22495083
55MP0001145_abnormal_male_reproductive1.20917425
56MP0001293_anophthalmia1.18489503
57MP0005174_abnormal_tail_pigmentation1.16453896
58MP0003315_abnormal_perineum_morphology1.10097982
59MP0002132_abnormal_respiratory_system1.09740279
60MP0001929_abnormal_gametogenesis1.09161099
61MP0000653_abnormal_sex_gland1.07645511
62MP0006292_abnormal_olfactory_placode1.07352953
63MP0009046_muscle_twitch1.07089251
64MP0008872_abnormal_physiological_respon1.06920458
65MP0001968_abnormal_touch/_nociception1.03488642
66MP0001764_abnormal_homeostasis1.01431657
67MP0005076_abnormal_cell_differentiation0.99917977
68MP0005084_abnormal_gallbladder_morpholo0.98894905
69MP0003787_abnormal_imprinting0.98044118
70MP0001529_abnormal_vocalization0.97631477
71MP0003186_abnormal_redox_activity0.97549906
72MP0005266_abnormal_metabolism0.96630029
73MP0003763_abnormal_thymus_physiology0.95676814
74MP0002254_reproductive_system_inflammat0.93778943
75MP0000383_abnormal_hair_follicle0.93743754
76MP0010030_abnormal_orbit_morphology0.92123968
77MP0003937_abnormal_limbs/digits/tail_de0.91441445
78MP0001119_abnormal_female_reproductive0.89885263
79MP0003941_abnormal_skin_development0.89225462
80MP0000371_diluted_coat_color0.89087001
81MP0000703_abnormal_thymus_morphology0.88909822
82MP0008875_abnormal_xenobiotic_pharmacok0.87819379
83MP0000647_abnormal_sebaceous_gland0.87451035
84MP0003221_abnormal_cardiomyocyte_apopto0.83048243
85MP0005408_hypopigmentation0.83011111
86MP0002398_abnormal_bone_marrow0.82721040
87MP0002722_abnormal_immune_system0.82292801
88MP0005395_other_phenotype0.81768562
89MP0000689_abnormal_spleen_morphology0.80181985
90MP0005023_abnormal_wound_healing0.79804817
91MP0009672_abnormal_birth_weight0.79471353
92MP0001485_abnormal_pinna_reflex0.79434949
93MP0002751_abnormal_autonomic_nervous0.79260835
94MP0005384_cellular_phenotype0.78999713
95MP0001188_hyperpigmentation0.78718260
96MP0005621_abnormal_cell_physiology0.78588972
97MP0004142_abnormal_muscle_tone0.78062853
98MP0005389_reproductive_system_phenotype0.77865692
99MP0005397_hematopoietic_system_phenotyp0.77566820
100MP0001545_abnormal_hematopoietic_system0.77566820
101MP0003943_abnormal_hepatobiliary_system0.76817323
102MP0004133_heterotaxia0.76413529
103MP0002095_abnormal_skin_pigmentation0.75999027
104MP0002163_abnormal_gland_morphology0.74876902
105MP0003698_abnormal_male_reproductive0.74177276
106MP0005645_abnormal_hypothalamus_physiol0.73961249
107MP0002160_abnormal_reproductive_system0.73883460
108MP0000858_altered_metastatic_potential0.73492199
109MP0001286_abnormal_eye_development0.73291604
110MP0002090_abnormal_vision0.71378291
111MP0003448_altered_tumor_morphology0.70984345
112MP0009703_decreased_birth_body0.70953129
113MP0002111_abnormal_tail_morphology0.69957290
114MP0009053_abnormal_anal_canal0.69464184
115MP0001915_intracranial_hemorrhage0.69414287
116MP0008260_abnormal_autophagy0.68886554
117MP0001853_heart_inflammation0.68596258
118MP0002006_tumorigenesis0.68472774
119MP0008995_early_reproductive_senescence0.68166200
120MP0003252_abnormal_bile_duct0.67847355
121MP0005646_abnormal_pituitary_gland0.66656713
122MP0002429_abnormal_blood_cell0.66253242
123MP0001324_abnormal_eye_pigmentation0.64816182
124MP0003119_abnormal_digestive_system0.64632729
125MP0000631_abnormal_neuroendocrine_gland0.63684045
126MP0000432_abnormal_head_morphology0.62813166
127MP0008789_abnormal_olfactory_epithelium0.62444167
128MP0005391_vision/eye_phenotype0.62331349
129MP0002138_abnormal_hepatobiliary_system0.62211872
130MP0005410_abnormal_fertilization0.61848531
131MP0002092_abnormal_eye_morphology0.61304538
132MP0009697_abnormal_copulation0.61278610
133MP0005075_abnormal_melanosome_morpholog0.60518597
134MP0003566_abnormal_cell_adhesion0.59083189
135MP0000358_abnormal_cell_content/0.58867711
136MP0003936_abnormal_reproductive_system0.57384209
137MP0002938_white_spotting0.57228128
138MP0005367_renal/urinary_system_phenotyp0.57145042
139MP0000516_abnormal_urinary_system0.57145042
140MP0001542_abnormal_bone_strength0.57119009
141MP0000716_abnormal_immune_system0.56176981
142MP0000428_abnormal_craniofacial_morphol0.55256204
143MP0006054_spinal_hemorrhage0.54909700
144MP0001919_abnormal_reproductive_system0.54890113
145MP0002405_respiratory_system_inflammati0.54548657
146MP0000627_abnormal_mammary_gland0.52140087
147MP0000537_abnormal_urethra_morphology0.51342350
148MP0000477_abnormal_intestine_morphology0.51252480

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.46422159
2Breast hypoplasia (HP:0003187)4.39918455
3Chromsome breakage (HP:0040012)3.99493970
4Carpal bone hypoplasia (HP:0001498)3.62625816
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47596489
6Degeneration of anterior horn cells (HP:0002398)3.41314130
7Abnormality of the anterior horn cell (HP:0006802)3.41314130
8Patellar aplasia (HP:0006443)3.38501865
9Pancreatic cysts (HP:0001737)3.33928398
10Oral leukoplakia (HP:0002745)3.27579532
11Abnormality of chromosome stability (HP:0003220)3.26876674
12Cerebral hypomyelination (HP:0006808)3.23438276
13Colon cancer (HP:0003003)3.22292015
14Agnosia (HP:0010524)3.20680771
15Aplasia/Hypoplasia of the patella (HP:0006498)3.20547098
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.18776894
17Abnormality of alanine metabolism (HP:0010916)3.18776894
18Hyperalaninemia (HP:0003348)3.18776894
19Rough bone trabeculation (HP:0100670)3.17421626
20Impulsivity (HP:0100710)3.16963172
21Absent radius (HP:0003974)3.16502905
22Increased CSF lactate (HP:0002490)3.15026215
23Abnormality of the labia minora (HP:0012880)3.10342570
24Meckel diverticulum (HP:0002245)3.04758980
25Molar tooth sign on MRI (HP:0002419)2.94698852
26Abnormality of midbrain morphology (HP:0002418)2.94698852
27Reticulocytopenia (HP:0001896)2.93258558
28Absent forearm bone (HP:0003953)2.92042407
29Aplasia involving forearm bones (HP:0009822)2.92042407
30Acute necrotizing encephalopathy (HP:0006965)2.91754480
31Abnormality of the preputium (HP:0100587)2.90429257
32Pancreatic fibrosis (HP:0100732)2.85697626
33Medulloblastoma (HP:0002885)2.83023007
34Mitochondrial inheritance (HP:0001427)2.82210442
35Selective tooth agenesis (HP:0001592)2.80562780
36Abnormality of the ileum (HP:0001549)2.79477232
37Increased hepatocellular lipid droplets (HP:0006565)2.77337720
38Lipid accumulation in hepatocytes (HP:0006561)2.69168566
39Acute encephalopathy (HP:0006846)2.65167418
40Hepatocellular necrosis (HP:0001404)2.64011927
41Abnormality of the pons (HP:0007361)2.62280259
42Duodenal stenosis (HP:0100867)2.61780722
43Small intestinal stenosis (HP:0012848)2.61780722
44Volvulus (HP:0002580)2.61513870
45Abnormal mitochondria in muscle tissue (HP:0008316)2.60754118
46Aplastic anemia (HP:0001915)2.57324908
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.57134634
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.56518652
49Ependymoma (HP:0002888)2.56224349
50Progressive macrocephaly (HP:0004481)2.55879628
51Myelodysplasia (HP:0002863)2.55130464
52Absent thumb (HP:0009777)2.54847274
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.53276425
54Hypoplasia of the pons (HP:0012110)2.50637254
55Abnormal spermatogenesis (HP:0008669)2.46206840
56Ectopic kidney (HP:0000086)2.45578374
5711 pairs of ribs (HP:0000878)2.44885107
58Premature graying of hair (HP:0002216)2.43635123
59Supernumerary spleens (HP:0009799)2.43363758
60True hermaphroditism (HP:0010459)2.42540557
61Fair hair (HP:0002286)2.42143511
62Increased serum lactate (HP:0002151)2.41297536
63Abnormal lung lobation (HP:0002101)2.41291220
64Bone marrow hypocellularity (HP:0005528)2.41111810
65Congenital, generalized hypertrichosis (HP:0004540)2.40772647
66Abnormal trabecular bone morphology (HP:0100671)2.39070889
67Nephronophthisis (HP:0000090)2.37582955
68Abnormality of cells of the erythroid lineage (HP:0012130)2.37536819
69Hepatic necrosis (HP:0002605)2.36199362
70Sloping forehead (HP:0000340)2.32202765
71Neoplasm of the pancreas (HP:0002894)2.31259552
72Stenosis of the external auditory canal (HP:0000402)2.25361723
73Abnormal number of erythroid precursors (HP:0012131)2.24397446
74Rhabdomyosarcoma (HP:0002859)2.23018064
75Deviation of the thumb (HP:0009603)2.21063482
76Irregular epiphyses (HP:0010582)2.20191004
77Abnormality of the duodenum (HP:0002246)2.19984140
78Small hand (HP:0200055)2.19768298
79Proximal placement of thumb (HP:0009623)2.19609521
80Horseshoe kidney (HP:0000085)2.19445972
81Methylmalonic acidemia (HP:0002912)2.16582511
82Aplasia/hypoplasia of the humerus (HP:0006507)2.15506010
83Gaze-evoked nystagmus (HP:0000640)2.13301080
84Trismus (HP:0000211)2.13008503
85Squamous cell carcinoma (HP:0002860)2.11991602
86Abolished electroretinogram (ERG) (HP:0000550)2.08704426
87Clubbing of toes (HP:0100760)2.08649440
88Abnormal number of incisors (HP:0011064)2.08249154
89Attenuation of retinal blood vessels (HP:0007843)2.08067440
90Abnormality of the renal cortex (HP:0011035)2.08021391
91Medial flaring of the eyebrow (HP:0010747)2.07904191
92Progressive inability to walk (HP:0002505)2.07559114
93Macrocytic anemia (HP:0001972)2.07374749
94Atresia of the external auditory canal (HP:0000413)2.07321485
95Abnormality of the renal medulla (HP:0100957)2.07210488
96Oligodactyly (hands) (HP:0001180)2.05520793
97Chronic hepatic failure (HP:0100626)2.05046979
98Glossoptosis (HP:0000162)2.04722480
99Secondary amenorrhea (HP:0000869)2.04002008
100Rectovaginal fistula (HP:0000143)2.01514606
101Rectal fistula (HP:0100590)2.01514606
102Cerebral edema (HP:0002181)2.00995912
103Duplicated collecting system (HP:0000081)2.00816055
104Premature ovarian failure (HP:0008209)2.00755001
105Abnormal protein glycosylation (HP:0012346)1.97781743
106Abnormal glycosylation (HP:0012345)1.97781743
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97781743
108Abnormal protein N-linked glycosylation (HP:0012347)1.97781743
109Methylmalonic aciduria (HP:0012120)1.96238974
110Triphalangeal thumb (HP:0001199)1.94726386
111Abnormality of serum amino acid levels (HP:0003112)1.93203726
112Tracheoesophageal fistula (HP:0002575)1.92670511
113Ureteral duplication (HP:0000073)1.92118512
114Pendular nystagmus (HP:0012043)1.90856261
115Tongue fasciculations (HP:0001308)1.90587953
116Lymphoma (HP:0002665)1.89981429
117Cellular immunodeficiency (HP:0005374)1.88353447
118Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88317951
119Lactic acidosis (HP:0003128)1.88026560
120Basal cell carcinoma (HP:0002671)1.87357454
121CNS hypomyelination (HP:0003429)1.86569702
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.86132116
123Congenital stationary night blindness (HP:0007642)1.85829106
124Short thumb (HP:0009778)1.85546363
125Spinal muscular atrophy (HP:0007269)1.83149546
126Hypoplasia of the radius (HP:0002984)1.83143553
127Glioma (HP:0009733)1.83140769
128Inability to walk (HP:0002540)1.83068948
129Increased nuchal translucency (HP:0010880)1.83031355
130Prominent nose (HP:0000448)1.82889414
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82821681
132Short tibia (HP:0005736)1.82731244
133Microretrognathia (HP:0000308)1.82499033
134Renal cortical cysts (HP:0000803)1.82347136
135Biliary tract neoplasm (HP:0100574)1.81769612
136Neoplasm of the colon (HP:0100273)1.81516573
137Cleft eyelid (HP:0000625)1.81369913
1383-Methylglutaconic aciduria (HP:0003535)1.80886003
139Abnormality of B cell number (HP:0010975)1.79666935
140Type I transferrin isoform profile (HP:0003642)1.79364314
141Intestinal atresia (HP:0011100)1.77061647
142Neoplasm of the oral cavity (HP:0100649)1.76847261
143Amaurosis fugax (HP:0100576)1.76635015
144IgG deficiency (HP:0004315)1.76447740
145B lymphocytopenia (HP:0010976)1.75692551
146Central scotoma (HP:0000603)1.74826175
147CNS demyelination (HP:0007305)1.74713087
148Fused cervical vertebrae (HP:0002949)1.73965916
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.73963436
150Abnormality of the umbilical cord (HP:0010881)1.73922158
151Intestinal fistula (HP:0100819)1.73574228
152Abnormality of the renal collecting system (HP:0004742)1.73246227
153Abnormal biliary tract morphology (HP:0012440)1.72973536
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.72691935
155Acute myeloid leukemia (HP:0004808)1.72645293
156Nephroblastoma (Wilms tumor) (HP:0002667)1.72481098
157Prostate neoplasm (HP:0100787)1.72196690
158Abnormality of methionine metabolism (HP:0010901)1.72033473
159Stillbirth (HP:0003826)1.71953506
160Oculomotor apraxia (HP:0000657)1.69723936
161Generalized hypopigmentation of hair (HP:0011358)1.68896504
162Renal Fanconi syndrome (HP:0001994)1.68443418
163Protruding tongue (HP:0010808)1.66175831
164Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66157142
165Hyperventilation (HP:0002883)1.65797548
166Pancytopenia (HP:0001876)1.65551120
167Exertional dyspnea (HP:0002875)1.65504834
168Optic disc pallor (HP:0000543)1.65317732
169Congenital primary aphakia (HP:0007707)1.62704367
170Median cleft lip (HP:0000161)1.62582490
171Respiratory failure (HP:0002878)1.61719128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50092665
2BUB14.24741972
3WEE14.12120903
4CDC73.90455708
5EIF2AK13.29309913
6PLK43.01301825
7TSSK62.96539321
8SRPK12.93030413
9TRIM282.58196021
10TTK2.57628186
11MKNK12.47207442
12NEK22.21379138
13MKNK22.18550628
14ACVR1B2.14532394
15BRSK22.05485293
16EPHA22.00947267
17PLK11.99689803
18PLK31.97694247
19NEK11.95183228
20EIF2AK31.93942123
21CDK121.80585415
22STK161.79356224
23MST41.78493003
24BRD41.67592269
25WNK31.63032528
26MAP4K21.58085312
27AURKB1.57670028
28PBK1.54938063
29NME21.51085461
30ATR1.48940702
31PNCK1.48256449
32ZAK1.47537746
33CDK71.46094548
34OXSR11.44732710
35STK101.41508931
36ADRBK21.40303763
37PASK1.34683316
38RPS6KA41.33020820
39CHEK21.32283092
40VRK21.31662304
41VRK11.30879823
42GRK11.26369820
43CHEK11.25687254
44RPS6KB21.23274827
45ERBB31.14364691
46DYRK31.09944183
47MELK1.06806788
48TAF11.06669386
49AURKA1.06431725
50CDK41.03109175
51MAP3K81.02457351
52PIM11.01971885
53TESK21.01850255
54IRAK31.00564194
55MAP3K121.00012619
56PIM20.99165837
57STK40.95445250
58EIF2AK20.94595350
59ATM0.93740108
60TNIK0.92964070
61BRSK10.89913379
62MAP3K40.88224261
63CDK190.87832369
64STK30.85170596
65STK38L0.83934589
66CDK20.83124567
67TGFBR10.83032330
68TLK10.81660503
69ALK0.80680639
70PAK40.80126627
71AKT30.77687845
72CSNK2A20.75098856
73CSNK1G20.74618024
74INSRR0.74415091
75CCNB10.72587844
76TXK0.70719222
77PLK20.70145147
78CSNK2A10.68883885
79STK390.67963374
80RPS6KA50.66948055
81TAOK30.66732917
82CDK10.65796727
83CDK60.63872687
84MAPK130.62979692
85NEK60.57663384
86PDK20.56208568
87ERBB40.54723694
88NME10.53943614
89PAK10.53559857
90SIK30.51224565
91NUAK10.50499466
92PRKCI0.47243400
93CDK30.47002729
94BCR0.46048196
95MAP3K30.45228680
96CSNK1E0.45195743
97BMPR1B0.45180193
98CHUK0.44347561
99WNK40.44167653
100CLK10.43776495
101SCYL20.43099837
102LATS10.43032837
103CDK80.41520593
104BRAF0.40988481
105TEC0.40985079
106ADRBK10.40706212
107CSNK1G30.39988099
108TIE10.39689505
109PAK30.39430929
110MAP2K70.39146238
111PRKCE0.38243137
112PRKCG0.37996857
113MAP2K30.37612699
114CASK0.35858588
115CSNK1A1L0.35782406
116IKBKB0.35017798
117CSNK1D0.33730584
118PRKDC0.32055025
119FLT30.31477180
120CSNK1G10.31432866
121ZAP700.31034249
122IRAK40.29677690
123STK240.27999737
124DAPK10.25093456
125MTOR0.24661290
126MAPK140.24400054
127CSNK1A10.24161539
128NLK0.23791445
129KDR0.23522995
130MET0.23038695
131PIK3CG0.22894067
132DYRK20.22766622
133MAP4K10.22264125
134PDK30.21545433

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34869423
2DNA replication_Homo sapiens_hsa030304.14122332
3Mismatch repair_Homo sapiens_hsa034303.87819843
4RNA polymerase_Homo sapiens_hsa030203.76397253
5Proteasome_Homo sapiens_hsa030503.54493075
6RNA transport_Homo sapiens_hsa030133.37761406
7Spliceosome_Homo sapiens_hsa030403.28624452
8Homologous recombination_Homo sapiens_hsa034402.96767167
9Ribosome_Homo sapiens_hsa030102.85709219
10Nucleotide excision repair_Homo sapiens_hsa034202.76361890
11Cell cycle_Homo sapiens_hsa041102.75013918
12Base excision repair_Homo sapiens_hsa034102.59316789
13Basal transcription factors_Homo sapiens_hsa030222.48272083
14One carbon pool by folate_Homo sapiens_hsa006702.40187191
15Fanconi anemia pathway_Homo sapiens_hsa034602.35794742
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35740838
17Pyrimidine metabolism_Homo sapiens_hsa002402.35666129
18Non-homologous end-joining_Homo sapiens_hsa034502.27888206
19RNA degradation_Homo sapiens_hsa030182.08406424
20Oxidative phosphorylation_Homo sapiens_hsa001901.98214254
21Propanoate metabolism_Homo sapiens_hsa006401.79894326
22mRNA surveillance pathway_Homo sapiens_hsa030151.78330734
23Parkinsons disease_Homo sapiens_hsa050121.71424515
24p53 signaling pathway_Homo sapiens_hsa041151.62968172
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56351988
26Vitamin B6 metabolism_Homo sapiens_hsa007501.41076837
27Purine metabolism_Homo sapiens_hsa002301.39980579
28Epstein-Barr virus infection_Homo sapiens_hsa051691.39969007
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36848781
30Phototransduction_Homo sapiens_hsa047441.34411245
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27808819
32Butanoate metabolism_Homo sapiens_hsa006501.12395252
33Protein export_Homo sapiens_hsa030601.09626698
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04797835
35Herpes simplex infection_Homo sapiens_hsa051681.04137627
36Antigen processing and presentation_Homo sapiens_hsa046121.01759127
37Tryptophan metabolism_Homo sapiens_hsa003801.00644371
38Nitrogen metabolism_Homo sapiens_hsa009100.96895886
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94497185
40Viral carcinogenesis_Homo sapiens_hsa052030.93838604
41Caffeine metabolism_Homo sapiens_hsa002320.93658196
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.93433351
43Alzheimers disease_Homo sapiens_hsa050100.93287418
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93237537
45Systemic lupus erythematosus_Homo sapiens_hsa053220.90654260
46Pyruvate metabolism_Homo sapiens_hsa006200.89339792
47Oocyte meiosis_Homo sapiens_hsa041140.87760756
48Steroid biosynthesis_Homo sapiens_hsa001000.83576492
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81353545
50Pentose phosphate pathway_Homo sapiens_hsa000300.80592593
51Selenocompound metabolism_Homo sapiens_hsa004500.78158275
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77686300
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74540233
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73283339
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72803250
56Legionellosis_Homo sapiens_hsa051340.69223614
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.69191231
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68450597
59HTLV-I infection_Homo sapiens_hsa051660.67642367
60Folate biosynthesis_Homo sapiens_hsa007900.67331737
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.66528892
62Peroxisome_Homo sapiens_hsa041460.61624682
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.60121052
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56523722
65MicroRNAs in cancer_Homo sapiens_hsa052060.56168052
66TGF-beta signaling pathway_Homo sapiens_hsa043500.54793415
67Ether lipid metabolism_Homo sapiens_hsa005650.54275050
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53918920
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53276732
70Sulfur metabolism_Homo sapiens_hsa009200.53021844
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52167761
72Fatty acid elongation_Homo sapiens_hsa000620.51393545
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.51317137
74Glutathione metabolism_Homo sapiens_hsa004800.51045898
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50509767
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49063562
77Biosynthesis of amino acids_Homo sapiens_hsa012300.48983910
78Measles_Homo sapiens_hsa051620.48148092
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47874894
80Nicotine addiction_Homo sapiens_hsa050330.47600301
81Small cell lung cancer_Homo sapiens_hsa052220.46451313
82Olfactory transduction_Homo sapiens_hsa047400.45660068
83Thyroid cancer_Homo sapiens_hsa052160.45436816
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45386890
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45285965
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.44778120
87Primary immunodeficiency_Homo sapiens_hsa053400.44054027
88Allograft rejection_Homo sapiens_hsa053300.42791953
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42779342
90Regulation of autophagy_Homo sapiens_hsa041400.42655595
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41736080
92Circadian rhythm_Homo sapiens_hsa047100.41694365
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.40527358
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39500500
95beta-Alanine metabolism_Homo sapiens_hsa004100.39243960
96Chemical carcinogenesis_Homo sapiens_hsa052040.39034165
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38524675
98Retinol metabolism_Homo sapiens_hsa008300.38268993
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37158282
100Hippo signaling pathway_Homo sapiens_hsa043900.36602931
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36482222
102Apoptosis_Homo sapiens_hsa042100.36466258
103Fatty acid degradation_Homo sapiens_hsa000710.35906567
104Hematopoietic cell lineage_Homo sapiens_hsa046400.35150247
105Adherens junction_Homo sapiens_hsa045200.35038250
106Shigellosis_Homo sapiens_hsa051310.33192721
107Huntingtons disease_Homo sapiens_hsa050160.31286245
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31172021
109Influenza A_Homo sapiens_hsa051640.30281276
110Fatty acid metabolism_Homo sapiens_hsa012120.28075246
111Lysine degradation_Homo sapiens_hsa003100.27765924
112Taste transduction_Homo sapiens_hsa047420.26963037
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26676905
114N-Glycan biosynthesis_Homo sapiens_hsa005100.26527964
115Arachidonic acid metabolism_Homo sapiens_hsa005900.26396772
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26297073
117Graft-versus-host disease_Homo sapiens_hsa053320.26064317
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25585015
119Asthma_Homo sapiens_hsa053100.25521452
120Hepatitis B_Homo sapiens_hsa051610.24574630
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24008984
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23334581
123HIF-1 signaling pathway_Homo sapiens_hsa040660.23085917
124Autoimmune thyroid disease_Homo sapiens_hsa053200.22084396
125Notch signaling pathway_Homo sapiens_hsa043300.21540079
126Fructose and mannose metabolism_Homo sapiens_hsa000510.20573466
127Pathways in cancer_Homo sapiens_hsa052000.19919214
128Colorectal cancer_Homo sapiens_hsa052100.19356138
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19338425
130Prostate cancer_Homo sapiens_hsa052150.19153836
131Viral myocarditis_Homo sapiens_hsa054160.17462821
132Vitamin digestion and absorption_Homo sapiens_hsa049770.16860235
133Tight junction_Homo sapiens_hsa045300.15532525
134Metabolic pathways_Homo sapiens_hsa011000.15483004
135Leishmaniasis_Homo sapiens_hsa051400.15359094
136Carbon metabolism_Homo sapiens_hsa012000.14941526
137Basal cell carcinoma_Homo sapiens_hsa052170.13710051
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.13197912
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.11672097
140Linoleic acid metabolism_Homo sapiens_hsa005910.11006485
141FoxO signaling pathway_Homo sapiens_hsa040680.10901623
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10214653
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.09146689
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08325266
145Type I diabetes mellitus_Homo sapiens_hsa049400.07924508

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