DOCK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)3.84289470
2hippo signaling (GO:0035329)3.40610038
3glomerular filtration (GO:0003094)3.39666997
4skin morphogenesis (GO:0043589)3.34736611
5axon extension involved in axon guidance (GO:0048846)3.33726429
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.33726429
7retina vasculature morphogenesis in camera-type eye (GO:0061299)3.32133961
8endothelial cell morphogenesis (GO:0001886)3.30762234
9chondrocyte proliferation (GO:0035988)3.29523928
10lymph vessel development (GO:0001945)3.29478210
11renal filtration (GO:0097205)3.27790507
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.27207388
13vascular endothelial growth factor signaling pathway (GO:0038084)3.27138572
14hemidesmosome assembly (GO:0031581)3.22999375
15regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.20544556
16cell adhesion mediated by integrin (GO:0033627)3.19763149
17glomerular basement membrane development (GO:0032836)3.19468148
18basement membrane organization (GO:0071711)3.16901540
19desmosome organization (GO:0002934)3.09447638
20apoptotic cell clearance (GO:0043277)3.08457314
21notochord development (GO:0030903)3.06649427
22protein heterotrimerization (GO:0070208)3.06155587
23negative regulation of chondrocyte differentiation (GO:0032331)3.05095926
24regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.04332856
25outer ear morphogenesis (GO:0042473)3.04164769
26regulation of SMAD protein import into nucleus (GO:0060390)3.02619877
27mesodermal cell differentiation (GO:0048333)2.98231789
28branching involved in salivary gland morphogenesis (GO:0060445)2.97932292
29collagen fibril organization (GO:0030199)2.97583572
30endocardial cushion development (GO:0003197)2.95859993
31cytoskeletal anchoring at plasma membrane (GO:0007016)2.95558954
32phagocytosis, recognition (GO:0006910)2.92826098
33Notch signaling involved in heart development (GO:0061314)2.91310163
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.86687304
35endodermal cell differentiation (GO:0035987)2.86577160
36regulation of transforming growth factor beta2 production (GO:0032909)2.85434855
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84960745
38mesenchymal cell proliferation (GO:0010463)2.83769264
39cell proliferation involved in metanephros development (GO:0072203)2.83309895
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78113632
41wound healing, spreading of epidermal cells (GO:0035313)2.77971040
42cell proliferation involved in kidney development (GO:0072111)2.77319245
43lymphangiogenesis (GO:0001946)2.76354101
44mammary gland development (GO:0030879)2.76327392
45positive regulation of SMAD protein import into nucleus (GO:0060391)2.75284650
46adherens junction assembly (GO:0034333)2.74311930
47fibroblast migration (GO:0010761)2.71355168
48craniofacial suture morphogenesis (GO:0097094)2.70469843
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70012320
50regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.69806945
51epithelial cell-cell adhesion (GO:0090136)2.67573031
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66699338
53blood vessel maturation (GO:0001955)2.66659125
54Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.66412827
55embryonic foregut morphogenesis (GO:0048617)2.65910758
56mesenchymal-epithelial cell signaling (GO:0060638)2.65682658
57positive regulation of p38MAPK cascade (GO:1900745)2.65438745
58dermatan sulfate biosynthetic process (GO:0030208)2.63852333
59cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63814462
60growth hormone receptor signaling pathway (GO:0060396)2.63594194
61negative regulation of fatty acid transport (GO:2000192)2.62964786
62cranial suture morphogenesis (GO:0060363)2.62169104
63regulation of endothelial cell differentiation (GO:0045601)2.61803932
64bone trabecula formation (GO:0060346)2.61009322
65gap junction assembly (GO:0016264)2.60949848
66protein localization to cell surface (GO:0034394)2.60760330
67organ induction (GO:0001759)2.60746389
68barbed-end actin filament capping (GO:0051016)2.60353032
69renal system development (GO:0072001)2.59316917
70insulin-like growth factor receptor signaling pathway (GO:0048009)2.59180024
71cell migration involved in sprouting angiogenesis (GO:0002042)2.58014531
72lateral sprouting from an epithelium (GO:0060601)2.56654012
73regulation of establishment of planar polarity (GO:0090175)2.56625305
74establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.56235043
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.55890353
76substrate adhesion-dependent cell spreading (GO:0034446)2.55405244
77regulation of heart morphogenesis (GO:2000826)2.54431575
78metanephric mesenchyme development (GO:0072075)2.54130720
79cellular response to growth hormone stimulus (GO:0071378)2.53915904
80bone remodeling (GO:0046849)2.52677182
81establishment of apical/basal cell polarity (GO:0035089)2.52605460
82adhesion of symbiont to host (GO:0044406)2.52151207
83anterior/posterior axis specification, embryo (GO:0008595)2.52146890
84embryonic skeletal joint morphogenesis (GO:0060272)2.51086280
85glomerular visceral epithelial cell development (GO:0072015)2.50838876
86glomerulus development (GO:0032835)2.49844629
87regulation of cardioblast differentiation (GO:0051890)2.48955455
88polarized epithelial cell differentiation (GO:0030859)2.48383580
89convergent extension (GO:0060026)2.47878997
90axis elongation (GO:0003401)2.47503698
91myelination in peripheral nervous system (GO:0022011)2.47414302
92peripheral nervous system axon ensheathment (GO:0032292)2.47414302
93planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45758405
94regulation of tight junction assembly (GO:2000810)2.44440879
95negative regulation of keratinocyte proliferation (GO:0010839)2.44131670
96smooth muscle tissue development (GO:0048745)2.43984788
97regulation of integrin-mediated signaling pathway (GO:2001044)2.43938093
98regulation of axon extension involved in axon guidance (GO:0048841)2.43619033
99negative regulation of cartilage development (GO:0061037)2.41826862
100kidney mesenchyme development (GO:0072074)2.41732661
101regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41668193
102cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41448310
103G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.41051974
104dermatan sulfate metabolic process (GO:0030205)2.40139062
105establishment or maintenance of bipolar cell polarity (GO:0061245)2.40104989
106establishment or maintenance of apical/basal cell polarity (GO:0035088)2.40104989
107bundle of His cell to Purkinje myocyte communication (GO:0086069)2.39610122
108regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39026351
109focal adhesion assembly (GO:0048041)2.38959913
110cell-substrate adherens junction assembly (GO:0007045)2.38959913
111collagen metabolic process (GO:0032963)2.38869727
112artery development (GO:0060840)2.38605956
113heart morphogenesis (GO:0003007)2.37445304
114positive regulation of mesenchymal cell proliferation (GO:0002053)2.37154563
115morphogenesis of an epithelial sheet (GO:0002011)2.36419341
116sequestering of extracellular ligand from receptor (GO:0035581)2.36157857
117regulation of mesenchymal cell proliferation (GO:0010464)2.35805900
118mesenchyme development (GO:0060485)2.35108591
119radial glial cell differentiation (GO:0060019)2.34788673
120non-canonical Wnt signaling pathway (GO:0035567)2.34594888
121positive regulation of macrophage cytokine production (GO:0060907)2.33836223
122apical protein localization (GO:0045176)2.32980966
123positive regulation of endothelial cell differentiation (GO:0045603)2.32830544
124positive regulation of epithelial to mesenchymal transition (GO:0010718)2.32465090
125regulation of integrin activation (GO:0033623)2.31884227
126ganglion development (GO:0061548)2.31540268
127cell-substrate junction assembly (GO:0007044)2.31052083
128embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30878107
129epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.28917060
130glomerular epithelial cell development (GO:0072310)2.28463774
131establishment of planar polarity (GO:0001736)2.28431994
132establishment of tissue polarity (GO:0007164)2.28431994
133multicellular organismal macromolecule metabolic process (GO:0044259)2.28312290
134muscle cell migration (GO:0014812)2.28165144
135adhesion of symbiont to host cell (GO:0044650)2.28023588
136virion attachment to host cell (GO:0019062)2.28023588
137cochlea morphogenesis (GO:0090103)2.27241134
138semaphorin-plexin signaling pathway (GO:0071526)2.26727855
139cell migration involved in heart development (GO:0060973)2.25988998
140extracellular matrix assembly (GO:0085029)2.24791917
141chondrocyte development (GO:0002063)2.24474106
142plasma membrane repair (GO:0001778)2.20911486
143multicellular organismal metabolic process (GO:0044236)2.19913468
144regulation of chondrocyte differentiation (GO:0032330)2.19546529
145collagen catabolic process (GO:0030574)2.19142285
146positive regulation of catenin import into nucleus (GO:0035413)2.19089622
147cell junction assembly (GO:0034329)2.18127395
148extracellular matrix disassembly (GO:0022617)2.16495460
149blood vessel endothelial cell migration (GO:0043534)2.16137022
150cell-cell junction assembly (GO:0007043)2.14999426
151negative regulation of catenin import into nucleus (GO:0035414)2.14713565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.56259334
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.98070232
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26301316
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73670318
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.58649705
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57470740
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.54350028
8CLOCK_20551151_ChIP-Seq_293T_Human2.41351984
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.39720994
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34075651
11E2F7_22180533_ChIP-Seq_HELA_Human2.33145672
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22466308
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19829651
14* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.16465448
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15508136
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10745588
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.08889460
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.08847355
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.06860258
20SALL4_18804426_ChIP-ChIP_XEN_Mouse2.05943659
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.05323559
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.01660577
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01162200
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98934743
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.98570545
26CJUN_26792858_Chip-Seq_BT549_Human1.97598580
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96706709
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93343094
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93343094
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93343094
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92089582
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92089582
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.87234759
34AR_21909140_ChIP-Seq_LNCAP_Human1.83396661
35* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.80088269
36BRD4_25478319_ChIP-Seq_HGPS_Human1.80019646
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.76257439
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73256996
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72529141
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.71320041
41* ESR2_21235772_ChIP-Seq_MCF-7_Human1.70968018
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.64252787
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.63160628
44* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61174334
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.57389122
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57152132
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53798127
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53663154
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53284785
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52111961
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52111961
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51189085
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.49703374
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49022996
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47477086
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.45353871
57TP53_16413492_ChIP-PET_HCT116_Human1.39448814
58ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39007436
59SOX2_20726797_ChIP-Seq_SW620_Human1.38935240
60GBX2_23144817_ChIP-Seq_PC3_Human1.38102876
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37575919
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35117889
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34871361
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33027895
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32479247
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32479247
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32380100
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.31640419
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31601550
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.30624672
71* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30453649
72* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28119338
73FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26906254
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26822834
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.26157953
76AHR_22903824_ChIP-Seq_MCF-7_Human1.23503123
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.22999461
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22235503
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20470773
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20363350
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20142860
82* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19892340
83TP53_18474530_ChIP-ChIP_U2OS_Human1.19587166
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.19478359
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.19478359
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.17708049
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16768390
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16485602
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15963846
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.15960124
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14367840
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13784294
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13775299
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11550987
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10783991
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10048637
97* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09904842
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09896484
99* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09225050
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.09153008
101SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08719443
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08448607
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07972095
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07878714
105RXR_22108803_ChIP-Seq_LS180_Human1.07592096
106GATA4_25053715_ChIP-Seq_YYC3_Human1.07474921
107* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06118199
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05645052
109* SMAD4_21799915_ChIP-Seq_A2780_Human1.02767690
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02064590
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01637279
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00676724
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00289738
114RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99069057
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99025158
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.98934011
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98894035
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98813068
119KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98433013
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97462433
121* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97376374
122VDR_24787735_ChIP-Seq_THP-1_Human0.97022867
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96732340
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.96395419
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.96322776
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96089248
127* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94852035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.71683440
2MP0003705_abnormal_hypodermis_morpholog3.79612581
3MP0004272_abnormal_basement_membrane3.33414387
4MP0005275_abnormal_skin_tensile2.92602978
5MP0005503_abnormal_tendon_morphology2.78536082
6MP0010030_abnormal_orbit_morphology2.62104420
7MP0010368_abnormal_lymphatic_system2.38962620
8MP0003279_aneurysm2.29776658
9MP0001958_emphysema2.23071750
10MP0005171_absent_coat_pigmentation2.17035246
11MP0001879_abnormal_lymphatic_vessel2.10248795
12MP0009780_abnormal_chondrocyte_physiolo2.05408609
13MP0003950_abnormal_plasma_membrane2.03460226
14MP0005623_abnormal_meninges_morphology2.00839573
15MP0003566_abnormal_cell_adhesion2.00309944
16MP0006054_spinal_hemorrhage1.96082506
17MP0003941_abnormal_skin_development1.93810912
18MP0010352_gastrointestinal_tract_polyps1.85939991
19MP0009053_abnormal_anal_canal1.84709109
20MP0000566_synostosis1.81242895
21MP0005409_darkened_coat_color1.68480480
22MP0000767_abnormal_smooth_muscle1.64325208
23MP0009384_cardiac_valve_regurgitation1.63932222
24MP0005508_abnormal_skeleton_morphology1.58035216
25MP0003385_abnormal_body_wall1.57845712
26MP0003828_pulmonary_edema1.50173704
27MP0005023_abnormal_wound_healing1.49797786
28MP0000537_abnormal_urethra_morphology1.49066210
29MP0000569_abnormal_digit_pigmentation1.45375929
30MP0009250_abnormal_appendicular_skeleto1.45292778
31MP0005076_abnormal_cell_differentiation1.43723471
32MP0003942_abnormal_urinary_system1.42125989
33MP0003091_abnormal_cell_migration1.41378038
34MP0000534_abnormal_ureter_morphology1.41337638
35MP0003115_abnormal_respiratory_system1.41046366
36MP0002060_abnormal_skin_morphology1.40819470
37MP0003937_abnormal_limbs/digits/tail_de1.40269339
38MP0005248_abnormal_Harderian_gland1.39810719
39* MP0000733_abnormal_muscle_development1.39796492
40MP0005257_abnormal_intraocular_pressure1.38755318
41MP0000579_abnormal_nail_morphology1.32736343
42MP0010678_abnormal_skin_adnexa1.28871157
43MP0002249_abnormal_larynx_morphology1.28593343
44MP0000383_abnormal_hair_follicle1.26811907
45MP0009278_abnormal_bone_marrow1.25666064
46MP0005367_renal/urinary_system_phenotyp1.23692516
47MP0000516_abnormal_urinary_system1.23692516
48MP0000462_abnormal_digestive_system1.22955491
49MP0002108_abnormal_muscle_morphology1.21513814
50MP0000751_myopathy1.19540056
51MP0002938_white_spotting1.17571891
52MP0003755_abnormal_palate_morphology1.15727175
53MP0000432_abnormal_head_morphology1.15524329
54MP0001915_intracranial_hemorrhage1.15029704
55MP0002282_abnormal_trachea_morphology1.14918987
56MP0003935_abnormal_craniofacial_develop1.14243643
57MP0002925_abnormal_cardiovascular_devel1.14050397
58MP0002295_abnormal_pulmonary_circulatio1.12919422
59MP0000762_abnormal_tongue_morphology1.11601153
60MP0003045_fibrosis1.10910090
61MP0005408_hypopigmentation1.10536237
62MP0000013_abnormal_adipose_tissue1.07584194
63MP0004858_abnormal_nervous_system1.06333197
64MP0006138_congestive_heart_failure1.06021723
65MP0010630_abnormal_cardiac_muscle1.03792478
66MP0003453_abnormal_keratinocyte_physiol1.02979585
67MP0000428_abnormal_craniofacial_morphol1.02707715
68MP0002128_abnormal_blood_circulation1.02019314
69MP0001614_abnormal_blood_vessel1.01584996
70MP0003136_yellow_coat_color1.01292729
71MP0003567_abnormal_fetal_cardiomyocyte1.00423910
72MP0005595_abnormal_vascular_smooth0.99475372
73MP0002697_abnormal_eye_size0.99045050
74MP0000049_abnormal_middle_ear0.98321334
75MP0000467_abnormal_esophagus_morphology0.97892590
76MP0002932_abnormal_joint_morphology0.96194515
77MP0002796_impaired_skin_barrier0.95364409
78MP0001293_anophthalmia0.95270544
79MP0000163_abnormal_cartilage_morphology0.94953088
80MP0002084_abnormal_developmental_patter0.92762933
81MP0003300_gastrointestinal_ulcer0.92594993
82MP0001849_ear_inflammation0.92339793
83MP0001175_abnormal_lung_morphology0.91810892
84MP0004233_abnormal_muscle_weight0.90256517
85MP0002111_abnormal_tail_morphology0.90218666
86MP0003868_abnormal_feces_composition0.89205448
87MP0002092_abnormal_eye_morphology0.88187363
88MP0002254_reproductive_system_inflammat0.87794135
89MP0002233_abnormal_nose_morphology0.87712303
90MP0002115_abnormal_skeleton_extremities0.87210331
91MP0004197_abnormal_fetal_growth/weight/0.87034387
92MP0002109_abnormal_limb_morphology0.85739279
93MP0000003_abnormal_adipose_tissue0.85707178
94MP0002877_abnormal_melanocyte_morpholog0.85107726
95MP0005167_abnormal_blood-brain_barrier0.83610299
96MP0001243_abnormal_dermal_layer0.83421774
97MP0003283_abnormal_digestive_organ0.83405578
98MP0005187_abnormal_penis_morphology0.83158340
99MP0004134_abnormal_chest_morphology0.82937663
100MP0002896_abnormal_bone_mineralization0.81122799
101MP0002168_other_aberrant_phenotype0.80948390
102MP0002085_abnormal_embryonic_tissue0.80943365
103MP0001299_abnormal_eye_distance/0.79745595
104MP0002009_preneoplasia0.78737242
105MP0002086_abnormal_extraembryonic_tissu0.77932476
106MP0000266_abnormal_heart_morphology0.77734367
107* MP0005388_respiratory_system_phenotype0.77299512
108* MP0002133_abnormal_respiratory_system0.77299512
109MP0002114_abnormal_axial_skeleton0.76513496
110MP0005197_abnormal_uvea_morphology0.76095817
111MP0003191_abnormal_cellular_cholesterol0.76026484
112MP0002098_abnormal_vibrissa_morphology0.75727429
113MP0001346_abnormal_lacrimal_gland0.75603399
114MP0002089_abnormal_postnatal_growth/wei0.75205732
115MP0002116_abnormal_craniofacial_bone0.74457363
116MP0010234_abnormal_vibrissa_follicle0.73448264
117MP0005390_skeleton_phenotype0.73080544
118MP0000749_muscle_degeneration0.71107487
119MP0002113_abnormal_skeleton_development0.70978872
120MP0002088_abnormal_embryonic_growth/wei0.70588987
121MP0003984_embryonic_growth_retardation0.70134813
122MP0003119_abnormal_digestive_system0.69917016
123MP0001286_abnormal_eye_development0.69304668
124MP0003890_abnormal_embryonic-extraembry0.67147077
125* MP0001177_atelectasis0.66694445
126MP0009672_abnormal_birth_weight0.65330704

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.93113806
2Premature rupture of membranes (HP:0001788)3.91167755
3Shallow orbits (HP:0000586)3.73105758
4Broad metatarsal (HP:0001783)3.55220996
5Ankle contracture (HP:0006466)3.20933660
6Short 4th metacarpal (HP:0010044)3.14844511
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.14844511
8Atrophic scars (HP:0001075)3.01674162
9Cerebral aneurysm (HP:0004944)2.91726508
10Aortic dissection (HP:0002647)2.87956610
11Aortic aneurysm (HP:0004942)2.59962605
12Abnormality of the 4th metacarpal (HP:0010012)2.56772777
13Syringomyelia (HP:0003396)2.44539202
14Spinal cord lesions (HP:0100561)2.44539202
15Neonatal short-limb short stature (HP:0008921)2.40595054
16Osteolytic defects of the hand bones (HP:0009699)2.40160682
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.40160682
18Soft skin (HP:0000977)2.38477570
19Abnormality of the nasal septum (HP:0000419)2.37927276
20Aplasia of the phalanges of the hand (HP:0009802)2.37610930
21Aplasia involving bones of the extremities (HP:0009825)2.37610930
22Aplasia involving bones of the upper limbs (HP:0009823)2.37610930
23Increased connective tissue (HP:0009025)2.28393220
24Mitral valve prolapse (HP:0001634)2.27621041
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.26629710
26Cervical subluxation (HP:0003308)2.26438619
27Coronal craniosynostosis (HP:0004440)2.25611665
28Pulmonary artery stenosis (HP:0004415)2.20916993
29Short hallux (HP:0010109)2.15209564
30Bladder diverticulum (HP:0000015)2.14072286
31Hematochezia (HP:0002573)2.13360325
32Blue sclerae (HP:0000592)2.09020788
33Vertebral arch anomaly (HP:0008438)2.06730232
34Ulnar bowing (HP:0003031)2.06066418
35Bell-shaped thorax (HP:0001591)2.04968946
36Fragile skin (HP:0001030)2.03270080
37Short nail (HP:0001799)2.02932296
38Asymmetry of the thorax (HP:0001555)2.02785968
39Bowel diverticulosis (HP:0005222)2.02677476
40Hypoplastic ischia (HP:0003175)2.00868290
41Vascular tortuosity (HP:0004948)2.00800013
42Follicular hyperkeratosis (HP:0007502)1.99828983
43Spinal rigidity (HP:0003306)1.99824393
44Urethral obstruction (HP:0000796)1.99489186
45Limited hip movement (HP:0008800)1.99171090
46Subacute progressive viral hepatitis (HP:0006572)1.98769017
47Wide anterior fontanel (HP:0000260)1.97808991
48Hypoplasia of the iris (HP:0007676)1.96772231
49Wormian bones (HP:0002645)1.96213054
50Arterial tortuosity (HP:0005116)1.95959380
51Genu recurvatum (HP:0002816)1.94955289
52Bronchomalacia (HP:0002780)1.94332065
53Aplasia/Hypoplasia of the hallux (HP:0008362)1.92895957
54Rectal prolapse (HP:0002035)1.90282472
55Thin bony cortex (HP:0002753)1.89605664
56Dilatation of the ascending aorta (HP:0005111)1.87627607
57Broad toe (HP:0001837)1.87081517
58Camptodactyly of toe (HP:0001836)1.86940070
59Abnormality of the acetabulum (HP:0003170)1.85462986
60Aneurysm (HP:0002617)1.84569851
61Broad thumb (HP:0011304)1.84489666
62Mesomelia (HP:0003027)1.84417826
63Abnormality of the ischium (HP:0003174)1.83738104
64Overgrowth (HP:0001548)1.82748184
65Turricephaly (HP:0000262)1.81995942
66Absent frontal sinuses (HP:0002688)1.81486508
67Right ventricular cardiomyopathy (HP:0011663)1.81382470
68Scapular winging (HP:0003691)1.80495131
69Deviation of the hallux (HP:0010051)1.79652539
70Natal tooth (HP:0000695)1.78422978
71Mitral stenosis (HP:0001718)1.78088108
72Mildly elevated creatine phosphokinase (HP:0008180)1.77851242
73Mitral regurgitation (HP:0001653)1.77303902
74Pterygium (HP:0001059)1.76779212
75Hyperacusis (HP:0010780)1.75853812
76Tarsal synostosis (HP:0008368)1.75736979
77Arnold-Chiari malformation (HP:0002308)1.75595576
78Abnormal delivery (HP:0001787)1.74777609
79Vertebral compression fractures (HP:0002953)1.72679271
80Broad long bones (HP:0005622)1.72108453
81Skull defect (HP:0001362)1.71503132
82Midline defect of the nose (HP:0004122)1.71322195
83Biconcave vertebral bodies (HP:0004586)1.70337480
84Flat acetabular roof (HP:0003180)1.70135546
85Renal duplication (HP:0000075)1.69716628
86Disproportionate tall stature (HP:0001519)1.68992381
87Hypoplastic labia majora (HP:0000059)1.67677308
88Abnormality of dentin (HP:0010299)1.67411969
89Aortic regurgitation (HP:0001659)1.67283795
90Hallux valgus (HP:0001822)1.67282911
91Esophageal varix (HP:0002040)1.67233220
92Partial duplication of the phalanx of hand (HP:0009999)1.66735890
93Abnormal ossification of hand bones (HP:0005921)1.66629605
94Joint laxity (HP:0001388)1.66262485
95Spondylolisthesis (HP:0003302)1.66246158
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66156796
97Abnormality of carpal bone ossification (HP:0006257)1.66111929
98Wrist flexion contracture (HP:0001239)1.66086965
99Tibial bowing (HP:0002982)1.65348896
100Absent toe (HP:0010760)1.64403337
101Lymphangioma (HP:0100764)1.64280743
102Synostosis involving bones of the lower limbs (HP:0009138)1.64123823
103Synostosis involving bones of the feet (HP:0009140)1.64123823
104Preaxial foot polydactyly (HP:0001841)1.63880825
105Alopecia of scalp (HP:0002293)1.63667289
106Hip contracture (HP:0003273)1.63538549
107Abnormality of the 2nd finger (HP:0004100)1.63345452
108Cutaneous finger syndactyly (HP:0010554)1.63183723
109Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62814944
110Advanced eruption of teeth (HP:0006288)1.62617081
111Broad hallux (HP:0010055)1.61220868
112Abnormal vertebral ossification (HP:0100569)1.60339026
113Hyperextensible skin (HP:0000974)1.60145871
114Peritonitis (HP:0002586)1.60053591
115Broad face (HP:0000283)1.59218556
116Synostosis of carpal bones (HP:0005048)1.58943072
117Selective tooth agenesis (HP:0001592)1.58298807
118Adactyly (HP:0009776)1.58187614
119Esophageal atresia (HP:0002032)1.56486639
120Aplasia cutis congenita (HP:0001057)1.55876848
121Broad phalanx (HP:0006009)1.55491895
122Milia (HP:0001056)1.54780427
123Vertebral clefting (HP:0008428)1.54072005
124Protruding ear (HP:0000411)1.54056106
125Breech presentation (HP:0001623)1.53993862
126Renovascular hypertension (HP:0100817)1.53938285
127Hepatoblastoma (HP:0002884)1.53533157
128Trigonocephaly (HP:0000243)1.52204500
129Type 1 muscle fiber predominance (HP:0003803)1.52026378
130Ankyloglossia (HP:0010296)1.51436932
131Cutaneous syndactyly (HP:0012725)1.50557051
132Midface retrusion (HP:0011800)1.50282079
133Pulmonic stenosis (HP:0001642)1.50242034
134Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.49866718
135Narrow palate (HP:0000189)1.48115623
136Abnormality of the epiphyses of the hand (HP:0005924)1.45371631
137Abnormal hand bone ossification (HP:0010660)1.45217134
138Knee flexion contracture (HP:0006380)1.44954557
139Ectopia lentis (HP:0001083)1.44736089
140Laryngomalacia (HP:0001601)1.44292826
141Abnormality of the phalanges of the hallux (HP:0010057)1.44258522
142Alacrima (HP:0000522)1.42506909
143Tracheal stenosis (HP:0002777)1.42091356
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42066116
145Spinal cord compression (HP:0002176)1.41739295
146Inguinal hernia (HP:0000023)1.40122597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.91770471
2NTRK12.66614449
3DDR22.62252938
4TTN2.61818076
5PDGFRA2.28751586
6CDK122.24270497
7MET2.19866546
8TRIB32.19423137
9TGFBR22.16513476
10TIE12.10605393
11MYLK2.02617857
12EEF2K2.01796575
13RIPK11.93924717
14PTK61.93785778
15CAMK1D1.90146852
16EPHB21.90011867
17STK31.85702615
18SIK11.77828718
19DMPK1.67979711
20FRK1.64877681
21BMX1.60464351
22LATS21.57881974
23FER1.56391177
24PRKD31.53281417
25NUAK11.53119236
26FGFR21.52990654
27EPHA21.51890349
28NEK91.49415532
29TRPM71.49382087
30TGFBR11.42991527
31EPHB11.41959968
32PDGFRB1.37644804
33STK38L1.36850481
34PKN21.35256974
35PAK41.30524397
36ERBB31.29753443
37PTK21.29737286
38LMTK21.29310644
39MKNK11.27936343
40ZAK1.27513415
41AKT31.26485333
42PIK3CA1.24533312
43PNCK1.22934119
44CDK61.14421086
45MST1R1.12645843
46MTOR1.10153834
47FGFR11.06834520
48CHUK1.06815937
49CAMK1G1.06029063
50EPHA31.04545792
51PAK21.02267357
52STK100.96857807
53TYRO30.95350778
54FGFR30.90113992
55TSSK60.89717711
56MAP3K30.89017514
57STK40.88821909
58KDR0.88504831
59ERBB20.88386652
60STK380.86819647
61FGFR40.86551326
62ERBB40.77181438
63WNK10.75655041
64SGK30.74515998
65FLT30.73849107
66LRRK20.73699186
67TTK0.73366583
68MKNK20.72881809
69MAP3K140.72445724
70GSK3A0.71828167
71ROCK10.66797425
72STK390.64016504
73TNIK0.61842090
74EPHA40.61833445
75RPS6KA40.61611902
76PRKD10.61318284
77PRKAA20.61190989
78NEK20.60224330
79PAK60.59742217
80RPS6KA20.59203512
81CDK70.57954505
82MOS0.57880664
83PAK30.57813070
84MAP3K80.57296857
85SGK20.56185221
86PTK2B0.56071487
87INSR0.55538076
88ERN10.53007852
89YES10.51081015
90RET0.50934377
91EIF2AK20.50751400
92MELK0.50456724
93PRKD20.49360064
94NEK60.48954970
95BRD40.48895684
96PBK0.48096829
97SCYL20.47996001
98CDC42BPA0.47284995
99BCR0.46952222
100SMG10.46227065
101MAP3K60.46072075
102PRKG20.46007569
103CLK10.45204025
104AURKB0.44509470
105IGF1R0.43994961
106MAP3K100.43962362
107ILK0.43589415
108MAPK70.43352262
109CSNK1A1L0.41675767
110SRC0.40275454
111JAK10.39115484
112ICK0.39023552
113CAMK2G0.38844315
114PRKCE0.38530917
115RPS6KB20.38507439
116BRSK20.38495343
117PDK20.38352372
118LIMK10.37926423
119* MAPK10.37840437
120SGK2230.37603968
121SGK4940.37603968
122ABL10.37549497
123CAMK2D0.36697930
124CAMK2B0.36511750
125ROCK20.36280914
126MAP2K10.35819971
127NEK10.35159813
128MAPK100.34658525
129CDK90.34384852
130MAP2K30.34118409
131CDK80.33821045
132STK240.32343502
133MAP3K70.32162839
134DAPK30.31352759
135MARK10.31028609
136MAP3K20.30052051
137CASK0.29198915
138AKT20.28959829

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.15362809
2Adherens junction_Homo sapiens_hsa045202.87163879
3* Focal adhesion_Homo sapiens_hsa045102.35762064
4Small cell lung cancer_Homo sapiens_hsa052222.20152177
5Basal cell carcinoma_Homo sapiens_hsa052172.19236000
6Proteoglycans in cancer_Homo sapiens_hsa052052.13474838
7MicroRNAs in cancer_Homo sapiens_hsa052061.98930233
8Hippo signaling pathway_Homo sapiens_hsa043901.96582689
9TGF-beta signaling pathway_Homo sapiens_hsa043501.90899929
10* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79444498
11Nitrogen metabolism_Homo sapiens_hsa009101.75649453
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70610415
13Malaria_Homo sapiens_hsa051441.59903929
14Tight junction_Homo sapiens_hsa045301.57996564
15Protein digestion and absorption_Homo sapiens_hsa049741.56884907
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55948258
17Viral myocarditis_Homo sapiens_hsa054161.52471725
18Prostate cancer_Homo sapiens_hsa052151.50486654
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49310850
20Amoebiasis_Homo sapiens_hsa051461.47860990
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.45333080
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.45143636
23Lysine degradation_Homo sapiens_hsa003101.38233398
24Notch signaling pathway_Homo sapiens_hsa043301.37692997
25Hedgehog signaling pathway_Homo sapiens_hsa043401.37273398
26Bladder cancer_Homo sapiens_hsa052191.34401985
27Dilated cardiomyopathy_Homo sapiens_hsa054141.33666059
28Melanoma_Homo sapiens_hsa052181.32121699
29Chronic myeloid leukemia_Homo sapiens_hsa052201.28586615
30Fatty acid biosynthesis_Homo sapiens_hsa000611.28167894
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.26883852
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25049496
33Pathways in cancer_Homo sapiens_hsa052001.23186792
34* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.17086201
35Toxoplasmosis_Homo sapiens_hsa051451.13691191
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07836428
37Gap junction_Homo sapiens_hsa045401.06713916
38Thyroid hormone synthesis_Homo sapiens_hsa049181.04764270
39Vitamin B6 metabolism_Homo sapiens_hsa007501.04098807
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01881087
41Endometrial cancer_Homo sapiens_hsa052131.00020958
42Pancreatic cancer_Homo sapiens_hsa052121.00018689
43Rap1 signaling pathway_Homo sapiens_hsa040150.96353206
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95714931
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95252009
46PPAR signaling pathway_Homo sapiens_hsa033200.93702967
47Estrogen signaling pathway_Homo sapiens_hsa049150.92466159
48Fatty acid metabolism_Homo sapiens_hsa012120.91759846
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89616456
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88402830
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87953419
52Thyroid cancer_Homo sapiens_hsa052160.87768018
53Histidine metabolism_Homo sapiens_hsa003400.85768501
54One carbon pool by folate_Homo sapiens_hsa006700.84470770
55ErbB signaling pathway_Homo sapiens_hsa040120.83664404
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.82515647
57Staphylococcus aureus infection_Homo sapiens_hsa051500.81646671
58HTLV-I infection_Homo sapiens_hsa051660.80721600
59TNF signaling pathway_Homo sapiens_hsa046680.80530192
60Axon guidance_Homo sapiens_hsa043600.80077941
61Bile secretion_Homo sapiens_hsa049760.79532040
62Insulin resistance_Homo sapiens_hsa049310.79504589
63Circadian rhythm_Homo sapiens_hsa047100.79179922
64Mineral absorption_Homo sapiens_hsa049780.78959742
65Fatty acid degradation_Homo sapiens_hsa000710.78216347
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77431276
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.75844887
68Wnt signaling pathway_Homo sapiens_hsa043100.75516830
69Inositol phosphate metabolism_Homo sapiens_hsa005620.74928848
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74868913
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74543631
72Prion diseases_Homo sapiens_hsa050200.73897880
73Pancreatic secretion_Homo sapiens_hsa049720.73645814
74Sphingolipid metabolism_Homo sapiens_hsa006000.73505311
75Renal cell carcinoma_Homo sapiens_hsa052110.71763575
76Cell cycle_Homo sapiens_hsa041100.70298801
77p53 signaling pathway_Homo sapiens_hsa041150.69668668
78Complement and coagulation cascades_Homo sapiens_hsa046100.69422977
79Arginine biosynthesis_Homo sapiens_hsa002200.68651742
80Renin-angiotensin system_Homo sapiens_hsa046140.68140994
81Melanogenesis_Homo sapiens_hsa049160.67981919
82Glucagon signaling pathway_Homo sapiens_hsa049220.67856075
83Dorso-ventral axis formation_Homo sapiens_hsa043200.67797983
84Renin secretion_Homo sapiens_hsa049240.66909208
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.66870798
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66555959
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64822969
88Platelet activation_Homo sapiens_hsa046110.64195622
89Apoptosis_Homo sapiens_hsa042100.62680163
90Salmonella infection_Homo sapiens_hsa051320.62344328
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62236061
92Arachidonic acid metabolism_Homo sapiens_hsa005900.60863447
93Choline metabolism in cancer_Homo sapiens_hsa052310.60187212
94Caffeine metabolism_Homo sapiens_hsa002320.59978910
95Colorectal cancer_Homo sapiens_hsa052100.59669608
96Influenza A_Homo sapiens_hsa051640.58949406
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58848622
98Steroid biosynthesis_Homo sapiens_hsa001000.57900512
99GnRH signaling pathway_Homo sapiens_hsa049120.56970337
100Viral carcinogenesis_Homo sapiens_hsa052030.56142970
101Gastric acid secretion_Homo sapiens_hsa049710.56040763
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55903653
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55148192
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54664430
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54420414
106Vitamin digestion and absorption_Homo sapiens_hsa049770.54036580
107Ovarian steroidogenesis_Homo sapiens_hsa049130.54033180
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.53707918
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53532884
110Insulin signaling pathway_Homo sapiens_hsa049100.53106788
111Glioma_Homo sapiens_hsa052140.53078767
112beta-Alanine metabolism_Homo sapiens_hsa004100.52875173
113Ras signaling pathway_Homo sapiens_hsa040140.52289084
114Hepatitis C_Homo sapiens_hsa051600.52109046
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52003492
116HIF-1 signaling pathway_Homo sapiens_hsa040660.51859328
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51236826
118Pertussis_Homo sapiens_hsa051330.51223715
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51209701
120Arginine and proline metabolism_Homo sapiens_hsa003300.51140965
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.50939357
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50640652
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50593990
124Glutathione metabolism_Homo sapiens_hsa004800.50206089
125Starch and sucrose metabolism_Homo sapiens_hsa005000.49609349
126Legionellosis_Homo sapiens_hsa051340.49607511
127FoxO signaling pathway_Homo sapiens_hsa040680.49337198
128Non-small cell lung cancer_Homo sapiens_hsa052230.49035312
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48863133
130cAMP signaling pathway_Homo sapiens_hsa040240.48153427
131Long-term potentiation_Homo sapiens_hsa047200.47897567
132Leishmaniasis_Homo sapiens_hsa051400.47372964
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.45295627
134African trypanosomiasis_Homo sapiens_hsa051430.44834103
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44521461
136AMPK signaling pathway_Homo sapiens_hsa041520.43886873
137Hepatitis B_Homo sapiens_hsa051610.43322602
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.42961251
139mTOR signaling pathway_Homo sapiens_hsa041500.42895554
140Chemical carcinogenesis_Homo sapiens_hsa052040.42658354
141Insulin secretion_Homo sapiens_hsa049110.42075333
142Cocaine addiction_Homo sapiens_hsa050300.41152330
143Endocytosis_Homo sapiens_hsa041440.40404916
144Glutamatergic synapse_Homo sapiens_hsa047240.39498842
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38719631
146Long-term depression_Homo sapiens_hsa047300.38301562

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