

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.64915670 |
| 2 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.14640929 |
| 3 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.14640929 |
| 4 | positive regulation by symbiont of host defense response (GO:0052509) | 5.12636197 |
| 5 | modulation by symbiont of host defense response (GO:0052031) | 5.12636197 |
| 6 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.12636197 |
| 7 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.12636197 |
| 8 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.12636197 |
| 9 | modulation by symbiont of host immune response (GO:0052553) | 5.12636197 |
| 10 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.85574805 |
| 11 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.63804595 |
| 12 | cellular extravasation (GO:0045123) | 4.58480111 |
| 13 | detection of molecule of bacterial origin (GO:0032490) | 4.49936776 |
| 14 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.40966659 |
| 15 | negative T cell selection (GO:0043383) | 4.35139262 |
| 16 | negative thymic T cell selection (GO:0045060) | 4.25319151 |
| 17 | negative regulation of cell killing (GO:0031342) | 4.18621500 |
| 18 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.18621500 |
| 19 | macrophage activation involved in immune response (GO:0002281) | 4.17148537 |
| 20 | regulation of gamma-delta T cell activation (GO:0046643) | 4.10344007 |
| 21 | microglial cell activation (GO:0001774) | 4.09710613 |
| 22 | neutrophil activation involved in immune response (GO:0002283) | 4.08672996 |
| 23 | detection of other organism (GO:0098543) | 4.06256472 |
| 24 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.99426264 |
| 25 | positive thymic T cell selection (GO:0045059) | 3.97862680 |
| 26 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.97321042 |
| 27 | negative regulation of T cell mediated immunity (GO:0002710) | 3.93627125 |
| 28 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.91597546 |
| 29 | detection of external biotic stimulus (GO:0098581) | 3.88779996 |
| 30 | positive regulation of B cell differentiation (GO:0045579) | 3.79912275 |
| 31 | negative regulation of interleukin-12 production (GO:0032695) | 3.76562148 |
| 32 | negative regulation of phagocytosis (GO:0050765) | 3.76141661 |
| 33 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.75723950 |
| 34 | response to peptidoglycan (GO:0032494) | 3.73734819 |
| 35 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.72944717 |
| 36 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.63790810 |
| 37 | response to host immune response (GO:0052572) | 3.58658375 |
| 38 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.58658375 |
| 39 | detection of bacterium (GO:0016045) | 3.56722768 |
| 40 | regulation of B cell differentiation (GO:0045577) | 3.55120648 |
| 41 | B cell receptor signaling pathway (GO:0050853) | 3.54312356 |
| 42 | positive T cell selection (GO:0043368) | 3.49677737 |
| 43 | macrophage activation (GO:0042116) | 3.46478765 |
| 44 | interferon-gamma production (GO:0032609) | 3.44366558 |
| 45 | myeloid cell activation involved in immune response (GO:0002275) | 3.42296952 |
| 46 | thymic T cell selection (GO:0045061) | 3.42076969 |
| 47 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.41620214 |
| 48 | response to host (GO:0075136) | 3.41620214 |
| 49 | response to host defenses (GO:0052200) | 3.41620214 |
| 50 | neutrophil mediated immunity (GO:0002446) | 3.41523543 |
| 51 | activated T cell proliferation (GO:0050798) | 3.41352562 |
| 52 | response to interleukin-15 (GO:0070672) | 3.41066365 |
| 53 | detection of biotic stimulus (GO:0009595) | 3.40799912 |
| 54 | T cell selection (GO:0045058) | 3.34683824 |
| 55 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.26818911 |
| 56 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.22741130 |
| 57 | respiratory burst (GO:0045730) | 3.22178073 |
| 58 | NIK/NF-kappaB signaling (GO:0038061) | 3.21995067 |
| 59 | positive regulation of mast cell activation (GO:0033005) | 3.21077999 |
| 60 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 3.17763366 |
| 61 | dosage compensation (GO:0007549) | 3.13831087 |
| 62 | T cell migration (GO:0072678) | 3.12318466 |
| 63 | myeloid leukocyte mediated immunity (GO:0002444) | 3.12011437 |
| 64 | response to muramyl dipeptide (GO:0032495) | 3.11702048 |
| 65 | neutrophil activation (GO:0042119) | 3.11016256 |
| 66 | T cell homeostasis (GO:0043029) | 3.09101302 |
| 67 | regulation of granulocyte differentiation (GO:0030852) | 3.08449088 |
| 68 | regulation of tolerance induction (GO:0002643) | 3.05559487 |
| 69 | nuclear pore complex assembly (GO:0051292) | 3.05151334 |
| 70 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.04420797 |
| 71 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.01922044 |
| 72 | leukocyte aggregation (GO:0070486) | 3.00801931 |
| 73 | regulation of mast cell degranulation (GO:0043304) | 3.00489093 |
| 74 | cellular response to interleukin-15 (GO:0071350) | 3.00072524 |
| 75 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.97603609 |
| 76 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.94225039 |
| 77 | mitotic sister chromatid cohesion (GO:0007064) | 2.94111849 |
| 78 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.90648180 |
| 79 | myeloid dendritic cell activation (GO:0001773) | 2.90213851 |
| 80 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.88194760 |
| 81 | histone H3-K36 demethylation (GO:0070544) | 2.86906330 |
| 82 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.86138911 |
| 83 | regulation of mast cell activation (GO:0033003) | 2.85861888 |
| 84 | definitive hemopoiesis (GO:0060216) | 2.84307241 |
| 85 | granulocyte activation (GO:0036230) | 2.82730224 |
| 86 | antigen receptor-mediated signaling pathway (GO:0050851) | 2.82700178 |
| 87 | DNA unwinding involved in DNA replication (GO:0006268) | 2.82032825 |
| 88 | cellular response to zinc ion (GO:0071294) | 2.81876245 |
| 89 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.81861131 |
| 90 | positive regulation of tolerance induction (GO:0002645) | 2.81370460 |
| 91 | regulation of mast cell activation involved in immune response (GO:0033006) | 2.81097306 |
| 92 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.80852511 |
| 93 | leukocyte degranulation (GO:0043299) | 2.80209236 |
| 94 | lymphocyte homeostasis (GO:0002260) | 2.79074860 |
| 95 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.76445133 |
| 96 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 2.76383843 |
| 97 | negative regulation of adaptive immune response (GO:0002820) | 2.76161568 |
| 98 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.75281963 |
| 99 | tolerance induction (GO:0002507) | 2.75116855 |
| 100 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.74757133 |
| 101 | germinal center formation (GO:0002467) | 2.74511559 |
| 102 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.74382823 |
| 103 | T cell costimulation (GO:0031295) | 2.74115219 |
| 104 | positive regulation of interleukin-2 production (GO:0032743) | 2.74090470 |
| 105 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.73561296 |
| 106 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.73561296 |
| 107 | regulation of T cell tolerance induction (GO:0002664) | 2.73537430 |
| 108 | mast cell activation (GO:0045576) | 2.73305103 |
| 109 | hepatocyte apoptotic process (GO:0097284) | 2.70999266 |
| 110 | B cell homeostasis (GO:0001782) | 2.70290280 |
| 111 | T cell proliferation (GO:0042098) | 2.69942780 |
| 112 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.69868879 |
| 113 | lymphocyte costimulation (GO:0031294) | 2.69260960 |
| 114 | positive regulation of isotype switching (GO:0045830) | 2.67334712 |
| 115 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.66445251 |
| 116 | T cell receptor signaling pathway (GO:0050852) | 2.65959430 |
| 117 | nuclear pore organization (GO:0006999) | 2.59608093 |
| 118 | ribosomal small subunit assembly (GO:0000028) | 2.59253465 |
| 119 | natural killer cell differentiation (GO:0001779) | 2.58156560 |
| 120 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.56250224 |
| 121 | immunoglobulin mediated immune response (GO:0016064) | 2.55994237 |
| 122 | negative regulation of B cell proliferation (GO:0030889) | 2.55466416 |
| 123 | response to type I interferon (GO:0034340) | 2.53038568 |
| 124 | regulation of DNA endoreduplication (GO:0032875) | 2.51854041 |
| 125 | pore complex assembly (GO:0046931) | 2.51078134 |
| 126 | natural killer cell activation (GO:0030101) | 2.48380238 |
| 127 | lymphocyte proliferation (GO:0046651) | 2.47861414 |
| 128 | mononuclear cell proliferation (GO:0032943) | 2.46813813 |
| 129 | type I interferon signaling pathway (GO:0060337) | 2.46394746 |
| 130 | cellular response to type I interferon (GO:0071357) | 2.46394746 |
| 131 | response to protozoan (GO:0001562) | 2.46246760 |
| 132 | regulation of response to interferon-gamma (GO:0060330) | 2.45372178 |
| 133 | interferon-gamma-mediated signaling pathway (GO:0060333) | 2.44999692 |
| 134 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.44960527 |
| 135 | leukocyte cell-cell adhesion (GO:0007159) | 2.44834399 |
| 136 | positive regulation of granulocyte differentiation (GO:0030854) | 2.44680449 |
| 137 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.43953882 |
| 138 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.43929732 |
| 139 | B cell proliferation (GO:0042100) | 2.43041911 |
| 140 | negative regulation of granulocyte differentiation (GO:0030853) | 2.42985457 |
| 141 | leukocyte homeostasis (GO:0001776) | 2.42497870 |
| 142 | mitotic chromosome condensation (GO:0007076) | 2.42240647 |
| 143 | histone mRNA catabolic process (GO:0071044) | 2.41790492 |
| 144 | defense response to protozoan (GO:0042832) | 2.39024452 |
| 145 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.38498242 |
| 146 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.38433411 |
| 147 | myeloid dendritic cell differentiation (GO:0043011) | 2.37452290 |
| 148 | actin nucleation (GO:0045010) | 2.34586254 |
| 149 | mature B cell differentiation (GO:0002335) | 2.33609008 |
| 150 | negative regulation of histone methylation (GO:0031061) | 2.32876848 |
| 151 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.32726794 |
| 152 | megakaryocyte development (GO:0035855) | 2.32478516 |
| 153 | positive regulation of B cell activation (GO:0050871) | 2.32129145 |
| 154 | leukocyte proliferation (GO:0070661) | 2.31557886 |
| 155 | regulation of B cell proliferation (GO:0030888) | 2.30427611 |
| 156 | immune response-activating cell surface receptor signaling pathway (GO:0002429) | 2.30248294 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.50147598 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.85632066 |
| 3 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 4.14724171 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.01250261 |
| 5 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.99960581 |
| 6 | MYC_22102868_ChIP-Seq_BL_Human | 3.39003539 |
| 7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.22371487 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.09860613 |
| 9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.81561736 |
| 10 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.72129608 |
| 11 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.70739108 |
| 12 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.70349413 |
| 13 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.68122760 |
| 14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.64065704 |
| 15 | MYB_26560356_Chip-Seq_TH2_Human | 2.53516057 |
| 16 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.49727254 |
| 17 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.49607441 |
| 18 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.48743606 |
| 19 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.48472315 |
| 20 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.43168150 |
| 21 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 2.41671596 |
| 22 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.36504542 |
| 23 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.35380109 |
| 24 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.31102371 |
| 25 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.25489868 |
| 26 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.24612480 |
| 27 | MAF_26560356_Chip-Seq_TH1_Human | 2.20894011 |
| 28 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.20848423 |
| 29 | MYB_26560356_Chip-Seq_TH1_Human | 2.20033629 |
| 30 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.19117340 |
| 31 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.16007834 |
| 32 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.14113367 |
| 33 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.09394752 |
| 34 | VDR_24787735_ChIP-Seq_THP-1_Human | 2.05847347 |
| 35 | UTX_26944678_Chip-Seq_JUKART_Human | 2.01404578 |
| 36 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.93725411 |
| 37 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.86288089 |
| 38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.84225436 |
| 39 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.81506394 |
| 40 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.80362840 |
| 41 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.80296613 |
| 42 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.80258832 |
| 43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.76625860 |
| 44 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.76590580 |
| 45 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.74174581 |
| 46 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68769303 |
| 47 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.68670949 |
| 48 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.63681777 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.62996877 |
| 50 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.58919941 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56242952 |
| 52 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.53495399 |
| 53 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.50952145 |
| 54 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.50659468 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50396478 |
| 56 | * SPI1_23127762_ChIP-Seq_K562_Human | 1.47118154 |
| 57 | GATA1_19941826_ChIP-Seq_K562_Human | 1.43300875 |
| 58 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.41366798 |
| 59 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.40629196 |
| 60 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.40362534 |
| 61 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.38962227 |
| 62 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38598454 |
| 63 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.36036109 |
| 64 | MAF_26560356_Chip-Seq_TH2_Human | 1.34847373 |
| 65 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.34772626 |
| 66 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.31093124 |
| 67 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.30140843 |
| 68 | GATA1_22025678_ChIP-Seq_K562_Human | 1.28320306 |
| 69 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.28152829 |
| 70 | GATA2_19941826_ChIP-Seq_K562_Human | 1.27216824 |
| 71 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.26085421 |
| 72 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.25385729 |
| 73 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.23363592 |
| 74 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.22973313 |
| 75 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.22680068 |
| 76 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.22630421 |
| 77 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.22133583 |
| 78 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.21735146 |
| 79 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.21253817 |
| 80 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.18964923 |
| 81 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.18062886 |
| 82 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16470043 |
| 83 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.13828616 |
| 84 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13091523 |
| 85 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.12528200 |
| 86 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12349731 |
| 87 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.07677518 |
| 88 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.03714284 |
| 89 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.03262356 |
| 90 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.02895411 |
| 91 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.02365032 |
| 92 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.00733716 |
| 93 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.00304230 |
| 94 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.98386224 |
| 95 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 0.98251604 |
| 96 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95605190 |
| 97 | GATA3_26560356_Chip-Seq_TH2_Human | 0.94293254 |
| 98 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93829404 |
| 99 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.93472708 |
| 100 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.93061868 |
| 101 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.92239881 |
| 102 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.91846073 |
| 103 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.89491926 |
| 104 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.87804184 |
| 105 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.86557044 |
| 106 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85302755 |
| 107 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.85161738 |
| 108 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.85143754 |
| 109 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.84922217 |
| 110 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.84489138 |
| 111 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.84321611 |
| 112 | ETS1_22383799_ChIP-Seq_G1ME_Mouse | 0.83957372 |
| 113 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.81151971 |
| 114 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.79977531 |
| 115 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.79411693 |
| 116 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.79195939 |
| 117 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.78339415 |
| 118 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.78038542 |
| 119 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.77543907 |
| 120 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.77144675 |
| 121 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.76565545 |
| 122 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.76243709 |
| 123 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.74534981 |
| 124 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.74386388 |
| 125 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.73742118 |
| 126 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.71497322 |
| 127 | GATA3_26560356_Chip-Seq_TH1_Human | 0.67274110 |
| 128 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.66192007 |
| 129 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.65910763 |
| 130 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.65856311 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 3.58103604 |
| 2 | MP0003763_abnormal_thymus_physiology | 3.23694850 |
| 3 | MP0002396_abnormal_hematopoietic_system | 3.15688877 |
| 4 | MP0005671_abnormal_response_to | 2.98743651 |
| 5 | MP0002166_altered_tumor_susceptibility | 2.95356255 |
| 6 | MP0000685_abnormal_immune_system | 2.89373662 |
| 7 | MP0001800_abnormal_humoral_immune | 2.84594807 |
| 8 | MP0002398_abnormal_bone_marrow | 2.53515558 |
| 9 | MP0004808_abnormal_hematopoietic_stem | 2.50378189 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.50092463 |
| 11 | MP0001790_abnormal_immune_system | 2.49975577 |
| 12 | MP0005387_immune_system_phenotype | 2.49975577 |
| 13 | MP0002452_abnormal_antigen_presenting | 2.46492151 |
| 14 | MP0002420_abnormal_adaptive_immunity | 2.42177434 |
| 15 | MP0001819_abnormal_immune_cell | 2.38929587 |
| 16 | MP0002006_tumorigenesis | 2.37436120 |
| 17 | MP0002723_abnormal_immune_serum | 2.36752811 |
| 18 | MP0003436_decreased_susceptibility_to | 2.35901399 |
| 19 | MP0000569_abnormal_digit_pigmentation | 2.34559354 |
| 20 | MP0008260_abnormal_autophagy | 2.29819506 |
| 21 | MP0003300_gastrointestinal_ulcer | 2.29000789 |
| 22 | MP0000716_abnormal_immune_system | 2.13993863 |
| 23 | MP0010352_gastrointestinal_tract_polyps | 2.12272348 |
| 24 | MP0000703_abnormal_thymus_morphology | 2.05361216 |
| 25 | MP0000689_abnormal_spleen_morphology | 2.04110585 |
| 26 | MP0005025_abnormal_response_to | 2.00723834 |
| 27 | MP0009785_altered_susceptibility_to | 2.00103325 |
| 28 | MP0002722_abnormal_immune_system | 1.99038122 |
| 29 | MP0003303_peritoneal_inflammation | 1.97067804 |
| 30 | MP0008057_abnormal_DNA_replication | 1.92689220 |
| 31 | MP0002419_abnormal_innate_immunity | 1.92141826 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 1.91806117 |
| 33 | MP0001545_abnormal_hematopoietic_system | 1.91556151 |
| 34 | MP0005397_hematopoietic_system_phenotyp | 1.91556151 |
| 35 | MP0002405_respiratory_system_inflammati | 1.91225959 |
| 36 | MP0009278_abnormal_bone_marrow | 1.87686473 |
| 37 | MP0010094_abnormal_chromosome_stability | 1.87072094 |
| 38 | MP0002429_abnormal_blood_cell | 1.83019431 |
| 39 | MP0005464_abnormal_platelet_physiology | 1.81300103 |
| 40 | MP0005174_abnormal_tail_pigmentation | 1.80668234 |
| 41 | MP0009333_abnormal_splenocyte_physiolog | 1.76486740 |
| 42 | MP0001873_stomach_inflammation | 1.73788021 |
| 43 | MP0005451_abnormal_body_composition | 1.71502272 |
| 44 | MP0004883_abnormal_blood_vessel | 1.68925602 |
| 45 | MP0010155_abnormal_intestine_physiology | 1.64923601 |
| 46 | MP0010307_abnormal_tumor_latency | 1.61957206 |
| 47 | MP0001853_heart_inflammation | 1.60202068 |
| 48 | MP0000465_gastrointestinal_hemorrhage | 1.59982314 |
| 49 | MP0002009_preneoplasia | 1.59510309 |
| 50 | MP0003077_abnormal_cell_cycle | 1.58984540 |
| 51 | MP0003656_abnormal_erythrocyte_physiolo | 1.57598044 |
| 52 | MP0003183_abnormal_peptide_metabolism | 1.54998680 |
| 53 | MP0004381_abnormal_hair_follicle | 1.53870538 |
| 54 | MP0003693_abnormal_embryo_hatching | 1.52999197 |
| 55 | MP0003191_abnormal_cellular_cholesterol | 1.50685015 |
| 56 | MP0005076_abnormal_cell_differentiation | 1.49043139 |
| 57 | MP0004947_skin_inflammation | 1.48274328 |
| 58 | MP0004130_abnormal_muscle_cell | 1.45621356 |
| 59 | MP0003866_abnormal_defecation | 1.43556588 |
| 60 | MP0001845_abnormal_inflammatory_respons | 1.41119829 |
| 61 | MP0000490_abnormal_crypts_of | 1.40631555 |
| 62 | MP0001851_eye_inflammation | 1.38797704 |
| 63 | MP0008007_abnormal_cellular_replicative | 1.31139666 |
| 64 | MP0000858_altered_metastatic_potential | 1.27657717 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 1.23903313 |
| 66 | MP0002877_abnormal_melanocyte_morpholog | 1.23880887 |
| 67 | MP0003690_abnormal_glial_cell | 1.23255318 |
| 68 | MP0003221_abnormal_cardiomyocyte_apopto | 1.20388935 |
| 69 | MP0005164_abnormal_response_to | 1.19705108 |
| 70 | MP0002019_abnormal_tumor_incidence | 1.19051375 |
| 71 | MP0004957_abnormal_blastocyst_morpholog | 1.18314592 |
| 72 | MP0004510_myositis | 1.18061159 |
| 73 | MP0006082_CNS_inflammation | 1.18020741 |
| 74 | MP0002933_joint_inflammation | 1.15904472 |
| 75 | MP0009764_decreased_sensitivity_to | 1.14362734 |
| 76 | MP0003448_altered_tumor_morphology | 1.13389646 |
| 77 | MP0003111_abnormal_nucleus_morphology | 1.12954742 |
| 78 | MP0003724_increased_susceptibility_to | 1.08289056 |
| 79 | MP0006054_spinal_hemorrhage | 1.05343634 |
| 80 | MP0000015_abnormal_ear_pigmentation | 1.04902426 |
| 81 | MP0002132_abnormal_respiratory_system | 1.04786650 |
| 82 | MP0003172_abnormal_lysosome_physiology | 1.04175852 |
| 83 | MP0008058_abnormal_DNA_repair | 1.01040854 |
| 84 | MP0002095_abnormal_skin_pigmentation | 0.97219898 |
| 85 | MP0008877_abnormal_DNA_methylation | 0.95022990 |
| 86 | MP0001533_abnormal_skeleton_physiology | 0.94872131 |
| 87 | MP0003121_genomic_imprinting | 0.94545277 |
| 88 | MP0000604_amyloidosis | 0.93830589 |
| 89 | MP0005310_abnormal_salivary_gland | 0.93398883 |
| 90 | MP0000350_abnormal_cell_proliferation | 0.93282756 |
| 91 | MP0003787_abnormal_imprinting | 0.90442203 |
| 92 | MP0000371_diluted_coat_color | 0.88031054 |
| 93 | MP0009115_abnormal_fat_cell | 0.86253581 |
| 94 | MP0009763_increased_sensitivity_to | 0.83056913 |
| 95 | MP0000313_abnormal_cell_death | 0.82674789 |
| 96 | MP0008469_abnormal_protein_level | 0.81327695 |
| 97 | MP0001986_abnormal_taste_sensitivity | 0.81290712 |
| 98 | MP0004185_abnormal_adipocyte_glucose | 0.79756954 |
| 99 | MP0000249_abnormal_blood_vessel | 0.77703160 |
| 100 | MP0003566_abnormal_cell_adhesion | 0.76326741 |
| 101 | MP0001730_embryonic_growth_arrest | 0.74128899 |
| 102 | MP0005666_abnormal_adipose_tissue | 0.69991390 |
| 103 | MP0008961_abnormal_basal_metabolism | 0.69899774 |
| 104 | MP0010234_abnormal_vibrissa_follicle | 0.69825500 |
| 105 | MP0004484_altered_response_of | 0.69596332 |
| 106 | MP0005388_respiratory_system_phenotype | 0.69024134 |
| 107 | MP0002133_abnormal_respiratory_system | 0.69024134 |
| 108 | MP0001348_abnormal_lacrimal_gland | 0.68659222 |
| 109 | MP0001915_intracranial_hemorrhage | 0.68314382 |
| 110 | MP0001958_emphysema | 0.67833844 |
| 111 | MP0002928_abnormal_bile_duct | 0.67253043 |
| 112 | MP0003091_abnormal_cell_migration | 0.66610246 |
| 113 | MP0009765_abnormal_xenobiotic_induced | 0.65930603 |
| 114 | MP0000343_altered_response_to | 0.65394526 |
| 115 | MP0002086_abnormal_extraembryonic_tissu | 0.64900465 |
| 116 | MP0002971_abnormal_brown_adipose | 0.64127403 |
| 117 | MP0003045_fibrosis | 0.62055217 |
| 118 | MP0005058_abnormal_lysosome_morphology | 0.61822951 |
| 119 | MP0001663_abnormal_digestive_system | 0.61344506 |
| 120 | MP0003075_altered_response_to | 0.61313226 |
| 121 | MP0003828_pulmonary_edema | 0.60938974 |
| 122 | MP0002998_abnormal_bone_remodeling | 0.60746210 |
| 123 | MP0005023_abnormal_wound_healing | 0.59922037 |
| 124 | MP0003943_abnormal_hepatobiliary_system | 0.59680797 |
| 125 | MP0005621_abnormal_cell_physiology | 0.58919118 |
| 126 | MP0005166_decreased_susceptibility_to | 0.57936538 |
| 127 | MP0000477_abnormal_intestine_morphology | 0.57681240 |
| 128 | MP0002088_abnormal_embryonic_growth/wei | 0.55222383 |
| 129 | MP0005390_skeleton_phenotype | 0.55213116 |
| 130 | MP0002075_abnormal_coat/hair_pigmentati | 0.54843857 |
| 131 | MP0003984_embryonic_growth_retardation | 0.54732251 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent viral infections (HP:0004429) | 4.24507782 |
| 2 | T lymphocytopenia (HP:0005403) | 3.95497204 |
| 3 | Gastrointestinal infarctions (HP:0005244) | 3.90851401 |
| 4 | Abnormality of macrophages (HP:0004311) | 3.84138899 |
| 5 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.82078733 |
| 6 | IgM deficiency (HP:0002850) | 3.80155502 |
| 7 | Abnormality of T cell number (HP:0011839) | 3.77438496 |
| 8 | Recurrent fungal infections (HP:0002841) | 3.75177219 |
| 9 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 3.70953589 |
| 10 | Abnormality of the fingertips (HP:0001211) | 3.63534567 |
| 11 | Panhypogammaglobulinemia (HP:0003139) | 3.56364102 |
| 12 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.54607980 |
| 13 | Recurrent bronchitis (HP:0002837) | 3.52276149 |
| 14 | Recurrent abscess formation (HP:0002722) | 3.50317636 |
| 15 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.45122131 |
| 16 | Chronic otitis media (HP:0000389) | 3.37977361 |
| 17 | Thrombocytosis (HP:0001894) | 3.34961190 |
| 18 | Abnormality of T cells (HP:0002843) | 3.34699086 |
| 19 | Myositis (HP:0100614) | 3.34616892 |
| 20 | Thyroiditis (HP:0100646) | 3.29139362 |
| 21 | Eczematoid dermatitis (HP:0000976) | 3.28472298 |
| 22 | Agammaglobulinemia (HP:0004432) | 3.23617111 |
| 23 | Recurrent bacterial skin infections (HP:0005406) | 3.06120222 |
| 24 | Cellulitis (HP:0100658) | 3.02789160 |
| 25 | Keratoconjunctivitis (HP:0001096) | 2.98515219 |
| 26 | Meningitis (HP:0001287) | 2.97199459 |
| 27 | Gastrointestinal inflammation (HP:0004386) | 2.93698271 |
| 28 | Inflammation of the large intestine (HP:0002037) | 2.92885670 |
| 29 | Gingival bleeding (HP:0000225) | 2.91445444 |
| 30 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.87158293 |
| 31 | Recurrent cutaneous fungal infections (HP:0011370) | 2.87158293 |
| 32 | Abnormality of B cell number (HP:0010975) | 2.87068142 |
| 33 | B lymphocytopenia (HP:0010976) | 2.87068142 |
| 34 | Vasculitis (HP:0002633) | 2.82561665 |
| 35 | Epistaxis (HP:0000421) | 2.80963375 |
| 36 | Lymphopenia (HP:0001888) | 2.79775672 |
| 37 | Mediastinal lymphadenopathy (HP:0100721) | 2.77073169 |
| 38 | Abnormality of T cell physiology (HP:0011840) | 2.75250581 |
| 39 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.72106130 |
| 40 | Volvulus (HP:0002580) | 2.69706894 |
| 41 | Peritonitis (HP:0002586) | 2.69319416 |
| 42 | Acute myeloid leukemia (HP:0004808) | 2.69016893 |
| 43 | Urticaria (HP:0001025) | 2.68458501 |
| 44 | Autoimmune hemolytic anemia (HP:0001890) | 2.67080208 |
| 45 | Colitis (HP:0002583) | 2.58757899 |
| 46 | Hematochezia (HP:0002573) | 2.56195611 |
| 47 | IgA deficiency (HP:0002720) | 2.55762795 |
| 48 | Severe combined immunodeficiency (HP:0004430) | 2.55393823 |
| 49 | Eosinophilia (HP:0001880) | 2.55306012 |
| 50 | IgG deficiency (HP:0004315) | 2.53845194 |
| 51 | Optic neuritis (HP:0100653) | 2.51820638 |
| 52 | Retrobulbar optic neuritis (HP:0100654) | 2.51820638 |
| 53 | Lymphoma (HP:0002665) | 2.51035299 |
| 54 | Nasal polyposis (HP:0100582) | 2.47979599 |
| 55 | Pulmonary embolism (HP:0002204) | 2.43854052 |
| 56 | Arterial thrombosis (HP:0004420) | 2.40952737 |
| 57 | Papilloma (HP:0012740) | 2.40775581 |
| 58 | Verrucae (HP:0200043) | 2.40775581 |
| 59 | Subacute progressive viral hepatitis (HP:0006572) | 2.39821070 |
| 60 | Chronic diarrhea (HP:0002028) | 2.39739485 |
| 61 | Leukocytosis (HP:0001974) | 2.38519029 |
| 62 | Orchitis (HP:0100796) | 2.37341663 |
| 63 | Combined immunodeficiency (HP:0005387) | 2.35760209 |
| 64 | Abnormality of the peritoneum (HP:0002585) | 2.34177187 |
| 65 | Slow saccadic eye movements (HP:0000514) | 2.33774508 |
| 66 | Periodontitis (HP:0000704) | 2.33116704 |
| 67 | Recurrent skin infections (HP:0001581) | 2.31083409 |
| 68 | Chest pain (HP:0100749) | 2.30253727 |
| 69 | Abnormality of eosinophils (HP:0001879) | 2.29993687 |
| 70 | Spontaneous hematomas (HP:0007420) | 2.29807005 |
| 71 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.29465412 |
| 72 | Amaurosis fugax (HP:0100576) | 2.28197686 |
| 73 | Granulocytopenia (HP:0001913) | 2.26296076 |
| 74 | Autoimmune thrombocytopenia (HP:0001973) | 2.25497586 |
| 75 | Gastrointestinal stroma tumor (HP:0100723) | 2.25244813 |
| 76 | Prolonged bleeding time (HP:0003010) | 2.24872404 |
| 77 | Stomatitis (HP:0010280) | 2.22905246 |
| 78 | Conjunctival telangiectasia (HP:0000524) | 2.21481465 |
| 79 | Osteomyelitis (HP:0002754) | 2.17706162 |
| 80 | Obstructive lung disease (HP:0006536) | 2.16447368 |
| 81 | Chronic obstructive pulmonary disease (HP:0006510) | 2.16447368 |
| 82 | Spinal cord lesions (HP:0100561) | 2.14696042 |
| 83 | Syringomyelia (HP:0003396) | 2.14696042 |
| 84 | Pulmonary infiltrates (HP:0002113) | 2.14253334 |
| 85 | Increased density of long bones (HP:0006392) | 2.07284002 |
| 86 | Hypoplasia of the thymus (HP:0000778) | 2.07044679 |
| 87 | Myelodysplasia (HP:0002863) | 2.07031760 |
| 88 | Anorexia (HP:0002039) | 2.06291216 |
| 89 | Abnormality of the pleura (HP:0002103) | 2.02401066 |
| 90 | Long eyelashes (HP:0000527) | 2.01950107 |
| 91 | Encephalitis (HP:0002383) | 2.00769842 |
| 92 | Abnormality of the nasal mucosa (HP:0000433) | 1.98920755 |
| 93 | Cutaneous melanoma (HP:0012056) | 1.98729082 |
| 94 | Viral hepatitis (HP:0006562) | 1.97946897 |
| 95 | Increased IgE level (HP:0003212) | 1.97811234 |
| 96 | Gingivitis (HP:0000230) | 1.97762679 |
| 97 | Pustule (HP:0200039) | 1.97585074 |
| 98 | Absent frontal sinuses (HP:0002688) | 1.97399842 |
| 99 | Glomerulopathy (HP:0100820) | 1.95453357 |
| 100 | Gangrene (HP:0100758) | 1.94528025 |
| 101 | Microcytic anemia (HP:0001935) | 1.93599598 |
| 102 | Increased IgM level (HP:0003496) | 1.93437617 |
| 103 | Macroorchidism (HP:0000053) | 1.93208461 |
| 104 | Hemoptysis (HP:0002105) | 1.92624559 |
| 105 | Abnormality of the prostate (HP:0008775) | 1.92435379 |
| 106 | Hypochromic microcytic anemia (HP:0004840) | 1.91229129 |
| 107 | Basal cell carcinoma (HP:0002671) | 1.91138614 |
| 108 | Episodic fever (HP:0001954) | 1.91099267 |
| 109 | Prominent nose (HP:0000448) | 1.90788091 |
| 110 | Acute hepatic failure (HP:0006554) | 1.85816842 |
| 111 | Recurrent sinusitis (HP:0011108) | 1.85408579 |
| 112 | Sepsis (HP:0100806) | 1.84170430 |
| 113 | Hyperacusis (HP:0010780) | 1.83978527 |
| 114 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.83080577 |
| 115 | Abnormal platelet volume (HP:0011876) | 1.83055999 |
| 116 | Chronic sinusitis (HP:0011109) | 1.82053232 |
| 117 | Papillary thyroid carcinoma (HP:0002895) | 1.81711903 |
| 118 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.79147477 |
| 119 | Interstitial pulmonary disease (HP:0006530) | 1.78989413 |
| 120 | Disinhibition (HP:0000734) | 1.78543426 |
| 121 | Bronchitis (HP:0012387) | 1.78287108 |
| 122 | Papilledema (HP:0001085) | 1.77878956 |
| 123 | Emphysema (HP:0002097) | 1.77688517 |
| 124 | Bicuspid aortic valve (HP:0001647) | 1.76320135 |
| 125 | Hypochromic anemia (HP:0001931) | 1.75605091 |
| 126 | Fatigue (HP:0012378) | 1.75002889 |
| 127 | Keratoconjunctivitis sicca (HP:0001097) | 1.73934731 |
| 128 | Cutis marmorata (HP:0000965) | 1.73540893 |
| 129 | Skin ulcer (HP:0200042) | 1.73308105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.47305316 |
| 2 | JAK3 | 2.98737812 |
| 3 | MAP3K10 | 2.80008675 |
| 4 | TXK | 2.72506812 |
| 5 | EEF2K | 2.58500396 |
| 6 | PRPF4B | 2.31578436 |
| 7 | TYK2 | 2.27319754 |
| 8 | KIT | 2.15308243 |
| 9 | ITK | 2.15217226 |
| 10 | BTK | 2.09787815 |
| 11 | TEC | 2.09783344 |
| 12 | FGFR3 | 2.08399521 |
| 13 | MAP3K14 | 2.07152875 |
| 14 | ZAP70 | 2.05786615 |
| 15 | CDK12 | 1.99110463 |
| 16 | STK10 | 1.98935363 |
| 17 | IRAK4 | 1.92765699 |
| 18 | CDC7 | 1.83087411 |
| 19 | BMPR2 | 1.73186561 |
| 20 | BRD4 | 1.62818105 |
| 21 | SYK | 1.61149539 |
| 22 | PKN2 | 1.58024236 |
| 23 | IKBKE | 1.54085647 |
| 24 | FGFR4 | 1.51552855 |
| 25 | GRK6 | 1.50816294 |
| 26 | JAK1 | 1.49742748 |
| 27 | FGR | 1.44341103 |
| 28 | TBK1 | 1.43606377 |
| 29 | CSF1R | 1.38617496 |
| 30 | LCK | 1.35409178 |
| 31 | LRRK2 | 1.31257885 |
| 32 | PASK | 1.28622834 |
| 33 | RPS6KA4 | 1.27365259 |
| 34 | FLT3 | 1.27104235 |
| 35 | HCK | 1.25359143 |
| 36 | BLK | 1.24125674 |
| 37 | IRAK1 | 1.23133302 |
| 38 | SCYL2 | 1.22866837 |
| 39 | PIM1 | 1.22447616 |
| 40 | MAP3K2 | 1.22188317 |
| 41 | ACVR1B | 1.22026765 |
| 42 | TGFBR1 | 1.20038670 |
| 43 | KSR2 | 1.19534278 |
| 44 | CAMKK2 | 1.18378429 |
| 45 | SIK3 | 1.17809722 |
| 46 | CHUK | 1.17514081 |
| 47 | IKBKB | 1.16581425 |
| 48 | CSK | 1.13373467 |
| 49 | MAP3K13 | 1.11691223 |
| 50 | HIPK2 | 1.09277040 |
| 51 | MAP3K1 | 1.08478738 |
| 52 | MAP3K6 | 1.07584813 |
| 53 | NEK2 | 1.07025804 |
| 54 | CDK6 | 1.05745079 |
| 55 | TNK2 | 1.04447986 |
| 56 | MAP2K3 | 1.03174005 |
| 57 | NLK | 1.02911238 |
| 58 | WNK1 | 1.01285075 |
| 59 | ATR | 0.97779717 |
| 60 | MARK3 | 0.97460791 |
| 61 | TGFBR2 | 0.96603911 |
| 62 | FRK | 0.95963304 |
| 63 | MARK2 | 0.95049224 |
| 64 | TRIB3 | 0.94437870 |
| 65 | CAMK1D | 0.92925454 |
| 66 | SGK2 | 0.92828736 |
| 67 | CDK4 | 0.91409492 |
| 68 | CDK9 | 0.90077457 |
| 69 | RPS6KB2 | 0.88397026 |
| 70 | IRAK2 | 0.85810090 |
| 71 | SGK3 | 0.83653286 |
| 72 | LYN | 0.83611907 |
| 73 | SIK2 | 0.82790808 |
| 74 | RAF1 | 0.81965711 |
| 75 | CLK1 | 0.80505692 |
| 76 | MAP3K3 | 0.80288824 |
| 77 | PDK1 | 0.79367094 |
| 78 | EPHA3 | 0.78519341 |
| 79 | PTK6 | 0.76906200 |
| 80 | JAK2 | 0.74347737 |
| 81 | ERN1 | 0.74254326 |
| 82 | TAOK3 | 0.74237914 |
| 83 | RIPK4 | 0.73717810 |
| 84 | STK4 | 0.73623546 |
| 85 | NEK9 | 0.72558295 |
| 86 | TTN | 0.66195391 |
| 87 | TRPM7 | 0.65504003 |
| 88 | MAP3K7 | 0.64134886 |
| 89 | EPHB1 | 0.62802534 |
| 90 | MAP3K8 | 0.61543964 |
| 91 | TSSK6 | 0.61040996 |
| 92 | ALK | 0.60856628 |
| 93 | MAPK12 | 0.59570205 |
| 94 | MAPK7 | 0.57110810 |
| 95 | PTK2B | 0.56495091 |
| 96 | MELK | 0.56268461 |
| 97 | FES | 0.53960474 |
| 98 | CAMKK1 | 0.51802506 |
| 99 | MKNK1 | 0.50993178 |
| 100 | KSR1 | 0.50835537 |
| 101 | FGFR2 | 0.50458739 |
| 102 | CAMK1G | 0.49736600 |
| 103 | MATK | 0.48691038 |
| 104 | PRKCQ | 0.47440914 |
| 105 | TAOK1 | 0.46875135 |
| 106 | FYN | 0.46692797 |
| 107 | RPS6KA5 | 0.46656042 |
| 108 | ATM | 0.44203424 |
| 109 | PDPK1 | 0.44084369 |
| 110 | GRK7 | 0.43722526 |
| 111 | MAP3K5 | 0.43700729 |
| 112 | PDGFRB | 0.43476049 |
| 113 | STK11 | 0.42565050 |
| 114 | CDK19 | 0.41866612 |
| 115 | MAPKAPK2 | 0.41718320 |
| 116 | CHEK1 | 0.41396165 |
| 117 | EGFR | 0.41385237 |
| 118 | BRSK2 | 0.40458017 |
| 119 | DYRK1B | 0.39568016 |
| 120 | MAPK15 | 0.39548533 |
| 121 | RPS6KA6 | 0.37982147 |
| 122 | AURKB | 0.36625706 |
| 123 | CAMK4 | 0.36162672 |
| 124 | CDK7 | 0.36056774 |
| 125 | PIM2 | 0.36055002 |
| 126 | PAK4 | 0.35555999 |
| 127 | PRKCH | 0.33617305 |
| 128 | STK38 | 0.33586035 |
| 129 | SGK1 | 0.32796872 |
| 130 | CDC42BPA | 0.32767289 |
| 131 | MTOR | 0.32479251 |
| 132 | DYRK3 | 0.32113598 |
| 133 | RPS6KC1 | 0.32003170 |
| 134 | RPS6KL1 | 0.32003170 |
| 135 | YES1 | 0.31501025 |
| 136 | PIK3CG | 0.30999604 |
| 137 | RET | 0.30453063 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.08057528 |
| 2 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.20727584 |
| 3 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.18524587 |
| 4 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.18074876 |
| 5 | Leishmaniasis_Homo sapiens_hsa05140 | 2.05885578 |
| 6 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.05085596 |
| 7 | Measles_Homo sapiens_hsa05162 | 1.99582201 |
| 8 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.97161767 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 1.92955877 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.89134778 |
| 11 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.82873944 |
| 12 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.75901683 |
| 13 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.74404884 |
| 14 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.63206976 |
| 15 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.58130362 |
| 16 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.51839317 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.51142645 |
| 18 | Allograft rejection_Homo sapiens_hsa05330 | 1.50768047 |
| 19 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.47961932 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.46845124 |
| 21 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.45942016 |
| 22 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.45819797 |
| 23 | Mismatch repair_Homo sapiens_hsa03430 | 1.44168223 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.42161464 |
| 25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.42071791 |
| 26 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.41903489 |
| 27 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.41603730 |
| 28 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.40235054 |
| 29 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.39474019 |
| 30 | Viral myocarditis_Homo sapiens_hsa05416 | 1.33943099 |
| 31 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.31451485 |
| 32 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.28741362 |
| 33 | Cell cycle_Homo sapiens_hsa04110 | 1.28293279 |
| 34 | Spliceosome_Homo sapiens_hsa03040 | 1.27656642 |
| 35 | Shigellosis_Homo sapiens_hsa05131 | 1.26947727 |
| 36 | Influenza A_Homo sapiens_hsa05164 | 1.26223388 |
| 37 | Apoptosis_Homo sapiens_hsa04210 | 1.24720873 |
| 38 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.23643826 |
| 39 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.22313533 |
| 40 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.20424121 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.16741059 |
| 42 | Legionellosis_Homo sapiens_hsa05134 | 1.15723162 |
| 43 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.15456689 |
| 44 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.14777313 |
| 45 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.14295131 |
| 46 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.13549727 |
| 47 | HTLV-I infection_Homo sapiens_hsa05166 | 1.12413411 |
| 48 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.09825291 |
| 49 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.09063859 |
| 50 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.06167971 |
| 51 | Colorectal cancer_Homo sapiens_hsa05210 | 1.05446566 |
| 52 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.05330024 |
| 53 | Tuberculosis_Homo sapiens_hsa05152 | 1.04386967 |
| 54 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.03358205 |
| 55 | Pertussis_Homo sapiens_hsa05133 | 1.00818665 |
| 56 | Platelet activation_Homo sapiens_hsa04611 | 1.00137335 |
| 57 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.00134323 |
| 58 | Phagosome_Homo sapiens_hsa04145 | 0.99119464 |
| 59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.99009324 |
| 60 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.96942753 |
| 61 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.96934577 |
| 62 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.96578948 |
| 63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.94462641 |
| 64 | Asthma_Homo sapiens_hsa05310 | 0.91443274 |
| 65 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.91404615 |
| 66 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.90673288 |
| 67 | Homologous recombination_Homo sapiens_hsa03440 | 0.88972853 |
| 68 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.88622570 |
| 69 | RNA transport_Homo sapiens_hsa03013 | 0.88101295 |
| 70 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88032368 |
| 71 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.85273172 |
| 72 | RNA degradation_Homo sapiens_hsa03018 | 0.85153274 |
| 73 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.84315529 |
| 74 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.83588476 |
| 75 | Salmonella infection_Homo sapiens_hsa05132 | 0.81545790 |
| 76 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.81001095 |
| 77 | Other glycan degradation_Homo sapiens_hsa00511 | 0.79589526 |
| 78 | Ribosome_Homo sapiens_hsa03010 | 0.79399899 |
| 79 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.79173881 |
| 80 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.76463997 |
| 81 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.74775783 |
| 82 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.74099078 |
| 83 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.74032533 |
| 84 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.73499231 |
| 85 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.73372427 |
| 86 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.72596472 |
| 87 | Thyroid cancer_Homo sapiens_hsa05216 | 0.72248074 |
| 88 | Hepatitis C_Homo sapiens_hsa05160 | 0.71778540 |
| 89 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.70591725 |
| 90 | Malaria_Homo sapiens_hsa05144 | 0.69856350 |
| 91 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.67422602 |
| 92 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.64925676 |
| 93 | Endometrial cancer_Homo sapiens_hsa05213 | 0.63491404 |
| 94 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.61892167 |
| 95 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.60923693 |
| 96 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.60427549 |
| 97 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.58472079 |
| 98 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.58325386 |
| 99 | Prostate cancer_Homo sapiens_hsa05215 | 0.57209749 |
| 100 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.55978477 |
| 101 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.55224315 |
| 102 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.53218926 |
| 103 | Amoebiasis_Homo sapiens_hsa05146 | 0.52886887 |
| 104 | Pathways in cancer_Homo sapiens_hsa05200 | 0.52636545 |
| 105 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.52040931 |
| 106 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50858139 |
| 107 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.50771848 |
| 108 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.50264014 |
| 109 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.49943756 |
| 110 | Long-term potentiation_Homo sapiens_hsa04720 | 0.49707848 |
| 111 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.49100715 |
| 112 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.48542808 |
| 113 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.48438277 |
| 114 | Insulin resistance_Homo sapiens_hsa04931 | 0.48355759 |
| 115 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.47946922 |
| 116 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46926849 |
| 117 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.46738862 |
| 118 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46624856 |
| 119 | Lysosome_Homo sapiens_hsa04142 | 0.45445976 |
| 120 | Glioma_Homo sapiens_hsa05214 | 0.44639481 |
| 121 | Endocytosis_Homo sapiens_hsa04144 | 0.44404277 |
| 122 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44269473 |
| 123 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.43627681 |
| 124 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.43168047 |
| 125 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.42612463 |
| 126 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.40894590 |
| 127 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.40667727 |
| 128 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.39153091 |

