DOCK11P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule metabolic process (GO:0044036)9.37293260
2regulation of cilium movement (GO:0003352)5.54643701
3positive regulation of mast cell activation (GO:0033005)5.54094972
4rRNA methylation (GO:0031167)5.53628127
5positive regulation of mast cell activation involved in immune response (GO:0033008)5.39366412
6positive regulation of mast cell degranulation (GO:0043306)5.39366412
7fusion of sperm to egg plasma membrane (GO:0007342)5.26470396
8regulation of MHC class II biosynthetic process (GO:0045346)5.24102844
9sperm motility (GO:0030317)5.09111785
10acrosome reaction (GO:0007340)5.08738994
11sperm-egg recognition (GO:0035036)4.91521367
12multicellular organism reproduction (GO:0032504)4.88015421
13rRNA modification (GO:0000154)4.77681114
14indolalkylamine metabolic process (GO:0006586)4.70682149
15protein polyglutamylation (GO:0018095)4.48005251
16glomerular visceral epithelial cell development (GO:0072015)4.47772443
17response to pheromone (GO:0019236)4.35815720
18establishment of protein localization to Golgi (GO:0072600)4.34398784
19regulation of T cell tolerance induction (GO:0002664)4.33692244
20cell-cell recognition (GO:0009988)4.10685306
21positive regulation of macrophage activation (GO:0043032)4.04641017
22cilium or flagellum-dependent cell motility (GO:0001539)4.03297915
23myelin assembly (GO:0032288)3.98918692
24glomerular epithelial cell development (GO:0072310)3.96995384
25protein targeting to Golgi (GO:0000042)3.94791239
26regulation of tolerance induction (GO:0002643)3.91884036
27regulation of T-helper 2 cell differentiation (GO:0045628)3.91786575
28reproduction (GO:0000003)3.83818077
29phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.78862876
30plasma membrane fusion (GO:0045026)3.77394238
31retinal rod cell development (GO:0046548)3.72110896
32positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.67394241
33retrograde transport, vesicle recycling within Golgi (GO:0000301)3.59558248
34centriole replication (GO:0007099)3.59519550
35response to acidic pH (GO:0010447)3.55376096
36positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.53312753
37spermatid development (GO:0007286)3.50258830
38sperm capacitation (GO:0048240)3.49989594
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39482955
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.35938551
41cellular response to pH (GO:0071467)3.34515007
42negative regulation of heart rate (GO:0010459)3.31890303
43single strand break repair (GO:0000012)3.31714033
44positive regulation of T-helper cell differentiation (GO:0045624)3.25196532
45indole-containing compound metabolic process (GO:0042430)3.20737749
46negative regulation of response to food (GO:0032096)3.19208517
47negative regulation of appetite (GO:0032099)3.19208517
48positive regulation of Rab GTPase activity (GO:0032851)3.18374872
49regulation of Rab GTPase activity (GO:0032313)3.18374872
50fibroblast migration (GO:0010761)3.17470471
51regulation of hypersensitivity (GO:0002883)3.13378949
52negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10665391
53positive regulation of leukocyte degranulation (GO:0043302)3.06797396
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05807610
55regulation of mast cell activation (GO:0033003)3.03143370
56histone H3-K4 trimethylation (GO:0080182)2.98715300
57cellular biogenic amine biosynthetic process (GO:0042401)2.97115275
58regulation of skeletal muscle contraction (GO:0014819)2.96654658
59protein localization to Golgi apparatus (GO:0034067)2.96156706
60positive regulation of tolerance induction (GO:0002645)2.95489966
61serotonin metabolic process (GO:0042428)2.94365001
62positive regulation of action potential (GO:0045760)2.93081449
63righting reflex (GO:0060013)2.92598835
64reflex (GO:0060004)2.91909221
65regulation of hippo signaling (GO:0035330)2.91229465
66regulation of microtubule-based movement (GO:0060632)2.90683014
67regulation of mast cell activation involved in immune response (GO:0033006)2.89797488
68regulation of mast cell degranulation (GO:0043304)2.85403552
69negative regulation of Rho protein signal transduction (GO:0035024)2.83150905
70amine biosynthetic process (GO:0009309)2.83039595
71photoreceptor cell maintenance (GO:0045494)2.82329399
72calcium ion-dependent exocytosis (GO:0017156)2.81528495
73acrosome assembly (GO:0001675)2.81306650
74cellular ketone body metabolic process (GO:0046950)2.80342711
75centriole assembly (GO:0098534)2.79484562
76negative regulation of systemic arterial blood pressure (GO:0003085)2.77961669
77brain morphogenesis (GO:0048854)2.77505540
78positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.77104868
79binding of sperm to zona pellucida (GO:0007339)2.76872044
80positive regulation of chemokine secretion (GO:0090197)2.76117630
81motile cilium assembly (GO:0044458)2.72969504
82primary amino compound metabolic process (GO:1901160)2.72555769
83spermatogenesis (GO:0007283)2.70080817
84male gamete generation (GO:0048232)2.69718752
85peptide catabolic process (GO:0043171)2.69203027
86positive regulation of interleukin-4 production (GO:0032753)2.68860070
87positive regulation of type 2 immune response (GO:0002830)2.68844425
88microtubule polymerization or depolymerization (GO:0031109)2.68622021
89monoubiquitinated protein deubiquitination (GO:0035520)2.66556354
90positive regulation of interleukin-1 beta secretion (GO:0050718)2.65084527
91regulation of cilium assembly (GO:1902017)2.64733041
92signal peptide processing (GO:0006465)2.64082859
93phosphatidylethanolamine metabolic process (GO:0046337)2.62617305
94indole-containing compound catabolic process (GO:0042436)2.60087164
95indolalkylamine catabolic process (GO:0046218)2.60087164
96tryptophan catabolic process (GO:0006569)2.60087164
97neural tube formation (GO:0001841)2.59055277
98male meiosis (GO:0007140)2.58942257
99detection of light stimulus involved in sensory perception (GO:0050962)2.57117491
100cell wall macromolecule catabolic process (GO:0016998)10.2379376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.11335812
2EZH2_22144423_ChIP-Seq_EOC_Human4.02476773
3VDR_22108803_ChIP-Seq_LS180_Human3.27265959
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17506107
5ZNF274_21170338_ChIP-Seq_K562_Hela2.76043720
6GBX2_23144817_ChIP-Seq_PC3_Human2.47372518
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.37197328
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.21371048
9UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.01141124
10TAF15_26573619_Chip-Seq_HEK293_Human1.98033324
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.96681622
12CBP_20019798_ChIP-Seq_JUKART_Human1.96681622
13BP1_19119308_ChIP-ChIP_Hs578T_Human1.94835813
14PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92428502
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91655208
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82841794
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.79516065
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78761556
19ER_23166858_ChIP-Seq_MCF-7_Human1.78053738
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77192571
21VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.71059481
22AR_21572438_ChIP-Seq_LNCaP_Human1.68412350
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66241725
24P300_19829295_ChIP-Seq_ESCs_Human1.64634885
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57249651
26FUS_26573619_Chip-Seq_HEK293_Human1.55939847
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53234544
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53234544
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51526871
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.49432730
31SMAD4_21799915_ChIP-Seq_A2780_Human1.48026083
32STAT3_23295773_ChIP-Seq_U87_Human1.47251698
33TCF4_23295773_ChIP-Seq_U87_Human1.46546268
34GATA3_26560356_Chip-Seq_TH2_Human1.44899424
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44623092
36KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43394947
37SALL4_22934838_ChIP-ChIP_CD34+_Human1.37627891
38RUNX_20019798_ChIP-Seq_JUKART_Human1.36590680
39TP53_22573176_ChIP-Seq_HFKS_Human1.36115240
40AR_25329375_ChIP-Seq_VCAP_Human1.35612688
41TCF4_22108803_ChIP-Seq_LS180_Human1.34871234
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34839868
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31896515
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.31065801
45IRF1_19129219_ChIP-ChIP_H3396_Human1.30208097
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29825444
47DROSHA_22980978_ChIP-Seq_HELA_Human1.29281026
48SOX2_19829295_ChIP-Seq_ESCs_Human1.27029014
49NANOG_19829295_ChIP-Seq_ESCs_Human1.27029014
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.26843232
51OCT4_20526341_ChIP-Seq_ESCs_Human1.25839897
52TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23384472
53RAC3_21632823_ChIP-Seq_H3396_Human1.21154635
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.20814888
55CEBPB_22108803_ChIP-Seq_LS180_Human1.19695841
56IGF1R_20145208_ChIP-Seq_DFB_Human1.19560135
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19325706
58TAF2_19829295_ChIP-Seq_ESCs_Human1.18475385
59FLI1_21867929_ChIP-Seq_TH2_Mouse1.18007685
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.17782857
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.17386243
62CDX2_22108803_ChIP-Seq_LS180_Human1.17170323
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16951490
64NANOG_20526341_ChIP-Seq_ESCs_Human1.16844695
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16831737
66MYC_19829295_ChIP-Seq_ESCs_Human1.16632699
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16056110
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14740197
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14631460
70BCAT_22108803_ChIP-Seq_LS180_Human1.14265505
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13835334
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13429266
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13296554
74RUNX2_22187159_ChIP-Seq_PCA_Human1.13116302
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11922932
76SMRT_27268052_Chip-Seq_Bcells_Human1.11805631
77REST_21632747_ChIP-Seq_MESCs_Mouse1.11086057
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10978588
79ERG_20517297_ChIP-Seq_VCAP_Human1.10845781
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10695695
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10470369
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09269467
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08146110
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06927719
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06799549
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.06511682
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06110421
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.05731472
89FOXH1_21741376_ChIP-Seq_EPCs_Human1.04855845
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04428774
91FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04102741
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.04102741
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03978338
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03932809
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03319378
96SCL_19346495_ChIP-Seq_HPC-7_Human1.03284589
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.03081747
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02396247
99STAT1_20625510_ChIP-Seq_HELA_Human1.02316220
100EWS_26573619_Chip-Seq_HEK293_Human1.01856991

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.27921226
2MP0003646_muscle_fatigue4.43294983
3MP0005377_hearing/vestibular/ear_phenot3.67496665
4MP0003878_abnormal_ear_physiology3.67496665
5MP0003011_delayed_dark_adaptation3.33244729
6MP0005551_abnormal_eye_electrophysiolog2.97431596
7MP0000569_abnormal_digit_pigmentation2.79596071
8MP0001835_abnormal_antigen_presentation2.59898874
9MP0008789_abnormal_olfactory_epithelium2.31212470
10MP0005360_urolithiasis2.20099709
11MP0005310_abnormal_salivary_gland2.06853766
12MP0001984_abnormal_olfaction2.05052073
13MP0003698_abnormal_male_reproductive2.04968147
14MP0005670_abnormal_white_adipose2.02465543
15MP0001485_abnormal_pinna_reflex2.01015826
16MP0005671_abnormal_response_to1.90263465
17MP0009764_decreased_sensitivity_to1.87917929
18MP0000372_irregular_coat_pigmentation1.76304736
19MP0001800_abnormal_humoral_immune1.71463537
20MP0005394_taste/olfaction_phenotype1.69611853
21MP0005499_abnormal_olfactory_system1.69611853
22MP0001765_abnormal_ion_homeostasis1.68702207
23MP0004147_increased_porphyrin_level1.67624074
24MP0001348_abnormal_lacrimal_gland1.64165880
25MP0003045_fibrosis1.55524055
26MP0001929_abnormal_gametogenesis1.54812620
27MP0004742_abnormal_vestibular_system1.53664760
28MP0004145_abnormal_muscle_electrophysio1.52011058
29MP0002148_abnormal_hypersensitivity_rea1.50251376
30MP0003879_abnormal_hair_cell1.50203705
31MP0002102_abnormal_ear_morphology1.46930032
32MP0006082_CNS_inflammation1.44879738
33MP0005636_abnormal_mineral_homeostasis1.42176939
34MP0009046_muscle_twitch1.40848188
35MP0005464_abnormal_platelet_physiology1.36209018
36MP0002876_abnormal_thyroid_physiology1.35520614
37MP0001970_abnormal_pain_threshold1.34605092
38MP0000566_synostosis1.33934962
39MP0001440_abnormal_grooming_behavior1.33128960
40MP0000230_abnormal_systemic_arterial1.32372048
41MP0003880_abnormal_central_pattern1.32361599
42MP0009785_altered_susceptibility_to1.31815799
43MP0008057_abnormal_DNA_replication1.31574546
44MP0002723_abnormal_immune_serum1.30634062
45MP0005647_abnormal_sex_gland1.29695905
46MP0002272_abnormal_nervous_system1.28075264
47MP0002938_white_spotting1.27819052
48MP0002557_abnormal_social/conspecific_i1.25278019
49MP0002127_abnormal_cardiovascular_syste1.25276774
50MP0005000_abnormal_immune_tolerance1.23233762
51MP0003195_calcinosis1.21155753
52MP0005253_abnormal_eye_physiology1.21043507
53MP0001486_abnormal_startle_reflex1.17804250
54MP0004142_abnormal_muscle_tone1.15380258
55MP0008775_abnormal_heart_ventricle1.14799373
56MP0005085_abnormal_gallbladder_physiolo1.12196131
57MP0003724_increased_susceptibility_to1.11186995
58MP0000470_abnormal_stomach_morphology1.09474534
59MP0005646_abnormal_pituitary_gland1.08792547
60MP0002452_abnormal_antigen_presenting1.08605740
61MP0002067_abnormal_sensory_capabilities1.05181507
62MP0009053_abnormal_anal_canal1.05167445
63MP0008872_abnormal_physiological_respon1.04850062
64MP0002572_abnormal_emotion/affect_behav1.04173434
65MP0000685_abnormal_immune_system1.03311579
66MP0002090_abnormal_vision1.00907744
67MP0001501_abnormal_sleep_pattern1.00305434
68MP0001968_abnormal_touch/_nociception0.95221367
69MP0001324_abnormal_eye_pigmentation0.95045506
70MP0003137_abnormal_impulse_conducting0.92473584
71MP0009697_abnormal_copulation0.92190750
72MP0005332_abnormal_amino_acid0.91708104
73MP0004924_abnormal_behavior0.91520171
74MP0005386_behavior/neurological_phenoty0.91520171
75MP0002161_abnormal_fertility/fecundity0.91141115
76MP0002229_neurodegeneration0.88864137
77MP0002168_other_aberrant_phenotype0.86196429
78MP0001963_abnormal_hearing_physiology0.84990719
79MP0002420_abnormal_adaptive_immunity0.84809252
80MP0001756_abnormal_urination0.84470185
81MP0004036_abnormal_muscle_relaxation0.83558077
82MP0005174_abnormal_tail_pigmentation0.81693501
83MP0002736_abnormal_nociception_after0.81401500
84MP0004215_abnormal_myocardial_fiber0.79593917
85MP0000026_abnormal_inner_ear0.79408934
86MP0001819_abnormal_immune_cell0.79284958
87MP0005195_abnormal_posterior_eye0.78510769
88MP0005423_abnormal_somatic_nervous0.77541045
89MP0002928_abnormal_bile_duct0.77244548
90MP0008877_abnormal_DNA_methylation0.75144345
91MP0003448_altered_tumor_morphology0.73206030
92MP0009745_abnormal_behavioral_response0.73027583
93MP0000371_diluted_coat_color0.71260289
94MP0005451_abnormal_body_composition0.71014183
95MP0005075_abnormal_melanosome_morpholog0.70517940
96MP0002064_seizures0.67789119
97MP0005025_abnormal_response_to0.67576555
98MP0002095_abnormal_skin_pigmentation0.66590436
99MP0005171_absent_coat_pigmentation0.66444216
100MP0003950_abnormal_plasma_membrane0.66194168

Predicted human phenotypes

RankGene SetZ-score
1Attenuation of retinal blood vessels (HP:0007843)4.42320455
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.26229929
3Absent/shortened dynein arms (HP:0200106)4.26229929
4Congenital stationary night blindness (HP:0007642)3.95828541
5Aplasia/Hypoplasia of the tibia (HP:0005772)3.95479403
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.64809094
7Exercise-induced muscle cramps (HP:0003710)3.42245168
8Short tibia (HP:0005736)3.41988927
9Aplasia/Hypoplasia of the fovea (HP:0008060)3.35040608
10Hypoplasia of the fovea (HP:0007750)3.35040608
11Enlarged epiphyses (HP:0010580)3.29976221
12Abnormality of the renal cortex (HP:0011035)3.25381293
13Bony spicule pigmentary retinopathy (HP:0007737)3.08707371
14Tubulointerstitial nephritis (HP:0001970)3.05845532
15Abnormal ciliary motility (HP:0012262)3.02383201
16Hyperkalemia (HP:0002153)3.01866028
17Pancreatic cysts (HP:0001737)3.00396150
18Renal cortical cysts (HP:0000803)2.94217403
19Abnormality of the fovea (HP:0000493)2.92413172
20Generalized aminoaciduria (HP:0002909)2.90863635
21Unilateral renal agenesis (HP:0000122)2.77305892
22Abnormal respiratory motile cilium physiology (HP:0012261)2.72386898
23Abnormality of the prostate (HP:0008775)2.68529646
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.65765140
25Severe visual impairment (HP:0001141)2.64732819
26Retinal dysplasia (HP:0007973)2.63820600
27Chorioretinal atrophy (HP:0000533)2.63517675
28Abnormal rod and cone electroretinograms (HP:0008323)2.62935594
29Polydipsia (HP:0001959)2.59493100
30Abnormal drinking behavior (HP:0030082)2.59493100
31Diplopia (HP:0000651)2.57228699
32Abnormality of binocular vision (HP:0011514)2.57228699
33Type II lissencephaly (HP:0007260)2.54053937
34Abnormal respiratory epithelium morphology (HP:0012253)2.50811029
35Abnormal respiratory motile cilium morphology (HP:0005938)2.50811029
36Short chin (HP:0000331)2.49725154
37Constricted visual fields (HP:0001133)2.46690993
38Abnormality of the renal medulla (HP:0100957)2.45653377
39Nephronophthisis (HP:0000090)2.45337834
40Abnormality of lateral ventricle (HP:0030047)2.40607906
41Abnormality of midbrain morphology (HP:0002418)2.38137675
42Molar tooth sign on MRI (HP:0002419)2.38137675
43Hypokinesia (HP:0002375)2.37833004
44Cerebellar dysplasia (HP:0007033)2.37587922
45Gastrointestinal infarctions (HP:0005244)2.37094259
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.34540945
47Abnormality of DNA repair (HP:0003254)2.33829855
48Fair hair (HP:0002286)2.31056693
49Metaphyseal dysplasia (HP:0100255)2.29489433
50Synostosis involving the elbow (HP:0003938)2.24103699
51Humeroradial synostosis (HP:0003041)2.24103699
52Hypothermia (HP:0002045)2.22152100
53Polyuria (HP:0000103)2.16193573
54Hemiplegia (HP:0002301)2.12596068
55Adactyly (HP:0009776)2.08585095
56Symphalangism affecting the phalanges of the hand (HP:0009773)2.06806895
57Fibular aplasia (HP:0002990)2.06742230
58Abnormality of macular pigmentation (HP:0008002)2.06553090
59Tinnitus (HP:0000360)2.05413675
60Aplasia/Hypoplasia of the macula (HP:0008059)2.04069562
61Exertional dyspnea (HP:0002875)2.03619882
62Abnormal urine output (HP:0012590)2.03272888
63Poor coordination (HP:0002370)2.02689625
64Pancreatic fibrosis (HP:0100732)2.02300462
65Hyperventilation (HP:0002883)2.01537584
66Potter facies (HP:0002009)2.00056709
67Facial shape deformation (HP:0011334)2.00056709
68Asplenia (HP:0001746)1.98802266
69Renal Fanconi syndrome (HP:0001994)1.97401407
70Aplasia/Hypoplasia affecting the retina (HP:0008061)1.96504715
71Chronic bronchitis (HP:0004469)1.96327229
72Decreased central vision (HP:0007663)1.95652038
73Chest pain (HP:0100749)1.93205661
74Congenital sensorineural hearing impairment (HP:0008527)1.90767583
75Periorbital edema (HP:0100539)1.90426318
76Clumsiness (HP:0002312)1.89271174
77Enlarged kidneys (HP:0000105)1.88880855
78Recurrent pneumonia (HP:0006532)1.88312604
79Decreased circulating renin level (HP:0003351)1.86095517
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85904622
81Abnormality of renal excretion (HP:0011036)1.85845040
82Renovascular hypertension (HP:0100817)1.84466033
83Tubular atrophy (HP:0000092)1.84266442
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.82329570
85Abolished electroretinogram (ERG) (HP:0000550)1.81566866
86Broad-based gait (HP:0002136)1.81371771
87Chronic diarrhea (HP:0002028)1.81057631
88Photophobia (HP:0000613)1.80487462
89Increased cerebral lipofuscin (HP:0011813)1.79961288
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.79654603
91Gait imbalance (HP:0002141)1.79514142
92Medial flaring of the eyebrow (HP:0010747)1.79121414
93Facial edema (HP:0000282)1.78818025
94Generalized hypopigmentation of hair (HP:0011358)1.76036435
95Gastrointestinal atresia (HP:0002589)1.75633104
96Pustule (HP:0200039)1.75572673
97Keratoconus (HP:0000563)1.75565107
98Increased corneal curvature (HP:0100692)1.75565107
99Congenital primary aphakia (HP:0007707)1.75313376
100Albinism (HP:0001022)1.74262251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.62757692
2FRK3.34210025
3TAOK33.31820123
4BCKDK3.29286265
5ARAF3.24030923
6MAP3K132.76092750
7PLK42.73759287
8BLK2.59186306
9KSR22.58629987
10INSRR2.51986375
11EPHA42.42825102
12PIK3CG2.36243170
13BMPR22.11307802
14MAP4K21.95943999
15DAPK21.81839163
16PLK21.80348585
17TXK1.80306670
18WNK41.73374405
19STK391.56383635
20EIF2AK31.56260829
21TNK21.51717738
22MOS1.51309096
23ZAK1.43456336
24EPHA31.42562539
25OXSR11.41369513
26RAF11.40984385
27DDR21.39668662
28GRK61.37750818
29ZAP701.36575504
30WNK11.31613828
31BRAF1.29670818
32PNCK1.28707433
33JAK31.23562226
34ADRBK21.23227988
35TAF11.21117071
36PAK31.16587524
37SYK1.11006705
38CDK121.08733977
39JAK21.08099438
40PDK10.99693206
41PRKCE0.97943447
42IKBKB0.93678592
43ITK0.93222862
44LYN0.91644222
45BRD40.88408631
46KSR10.87258517
47PTK2B0.84924946
48CDK30.84516944
49CAMK1G0.84130838
50TEC0.82348154
51LIMK10.82207958
52MAPK130.80845665
53KIT0.77659826
54RIPK40.76919891
55KDR0.72428365
56BTK0.68067144
57RPS6KA20.64857963
58MAP3K20.64838195
59OBSCN0.59108858
60NTRK30.58759368
61ACVR1B0.58488879
62TLK10.58224847
63CSF1R0.57802283
64MAP4K10.57327126
65DAPK30.53538790
66RPS6KA60.53304434
67PDPK10.53090242
68STK160.53084537
69MAP3K10.52659371
70PAK10.52480429
71MAP2K10.51568825
72IKBKE0.49965308
73GRK10.48338511
74IRAK10.46880027
75GRK50.46328024
76MUSK0.45775575
77RPS6KC10.44636082
78RPS6KL10.44636082
79TESK10.43363070
80CDK190.42236440
81GRK70.41162114
82WNK30.40009554
83RPS6KA50.39765442
84MAP2K20.39258105
85BRSK20.39024061
86PIM10.36271688
87RPS6KA10.35347016
88SIK20.34838357
89NTRK20.34284077
90PRKCQ0.33783544
91PRKG10.31497310
92TIE10.30863930
93HIPK20.29297537
94CAMK10.28280745
95ADRBK10.28252686
96HCK0.26727850
97MARK10.26413278
98PAK60.26015832
99MAPK120.25890506
100LCK0.25655795

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.58858576
2Autoimmune thyroid disease_Homo sapiens_hsa053204.39297090
3Graft-versus-host disease_Homo sapiens_hsa053324.35516412
4Asthma_Homo sapiens_hsa053104.16864283
5Type I diabetes mellitus_Homo sapiens_hsa049403.65554075
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.30020221
7Phototransduction_Homo sapiens_hsa047442.64773465
8Viral myocarditis_Homo sapiens_hsa054162.30527065
9Antigen processing and presentation_Homo sapiens_hsa046122.13976330
10Staphylococcus aureus infection_Homo sapiens_hsa051502.01752642
11Olfactory transduction_Homo sapiens_hsa047401.99713303
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64396136
13Selenocompound metabolism_Homo sapiens_hsa004501.63890495
14Tryptophan metabolism_Homo sapiens_hsa003801.60435129
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53401393
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50448839
17Leishmaniasis_Homo sapiens_hsa051401.45135210
18Rheumatoid arthritis_Homo sapiens_hsa053231.38689430
19Systemic lupus erythematosus_Homo sapiens_hsa053221.30895778
20Linoleic acid metabolism_Homo sapiens_hsa005911.25592967
21Phagosome_Homo sapiens_hsa041451.19620122
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16850408
23Taste transduction_Homo sapiens_hsa047421.16562030
24Sulfur metabolism_Homo sapiens_hsa009201.11698530
25Cardiac muscle contraction_Homo sapiens_hsa042601.11471478
26Platelet activation_Homo sapiens_hsa046111.09652920
27Dorso-ventral axis formation_Homo sapiens_hsa043201.09528380
28Basal transcription factors_Homo sapiens_hsa030221.06783655
29Oxidative phosphorylation_Homo sapiens_hsa001901.04491998
30Vascular smooth muscle contraction_Homo sapiens_hsa042701.02962909
31Nitrogen metabolism_Homo sapiens_hsa009101.02409040
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01884449
33Chemical carcinogenesis_Homo sapiens_hsa052041.01834745
34Morphine addiction_Homo sapiens_hsa050321.00380063
35Ether lipid metabolism_Homo sapiens_hsa005650.97488125
36Serotonergic synapse_Homo sapiens_hsa047260.93421979
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90120341
38Hematopoietic cell lineage_Homo sapiens_hsa046400.89094903
39Huntingtons disease_Homo sapiens_hsa050160.88899557
40Tuberculosis_Homo sapiens_hsa051520.88132685
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87089054
42Salivary secretion_Homo sapiens_hsa049700.87075116
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.83647877
44Long-term depression_Homo sapiens_hsa047300.82097781
45Influenza A_Homo sapiens_hsa051640.79872822
46Arachidonic acid metabolism_Homo sapiens_hsa005900.79638353
47Butanoate metabolism_Homo sapiens_hsa006500.79524674
48Parkinsons disease_Homo sapiens_hsa050120.78378479
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76451962
50Circadian entrainment_Homo sapiens_hsa047130.75262679
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.74982751
52Gastric acid secretion_Homo sapiens_hsa049710.73726158
53Retinol metabolism_Homo sapiens_hsa008300.73588841
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70677062
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69293401
56Oxytocin signaling pathway_Homo sapiens_hsa049210.67604049
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66794249
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63812894
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63414883
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63211399
61Toxoplasmosis_Homo sapiens_hsa051450.62208924
62Cholinergic synapse_Homo sapiens_hsa047250.62205557
63Homologous recombination_Homo sapiens_hsa034400.62144899
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59795497
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59532581
66Glutamatergic synapse_Homo sapiens_hsa047240.58966675
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57674015
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51476033
69Alzheimers disease_Homo sapiens_hsa050100.51264426
70cAMP signaling pathway_Homo sapiens_hsa040240.49860884
71Insulin secretion_Homo sapiens_hsa049110.49706592
72Propanoate metabolism_Homo sapiens_hsa006400.49644375
73Estrogen signaling pathway_Homo sapiens_hsa049150.49509695
74ABC transporters_Homo sapiens_hsa020100.46789083
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45705846
76T cell receptor signaling pathway_Homo sapiens_hsa046600.45398743
77Renin secretion_Homo sapiens_hsa049240.44576875
78Calcium signaling pathway_Homo sapiens_hsa040200.44055209
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42460827
80Chemokine signaling pathway_Homo sapiens_hsa040620.41802728
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39931743
82Regulation of autophagy_Homo sapiens_hsa041400.39124544
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38511838
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35841778
85GABAergic synapse_Homo sapiens_hsa047270.35357734
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.35309428
87Ovarian steroidogenesis_Homo sapiens_hsa049130.35033400
88Thyroid hormone synthesis_Homo sapiens_hsa049180.33911068
89Pancreatic secretion_Homo sapiens_hsa049720.32335085
90beta-Alanine metabolism_Homo sapiens_hsa004100.31965831
91Herpes simplex infection_Homo sapiens_hsa051680.29633445
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.29254216
93Legionellosis_Homo sapiens_hsa051340.28626937
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27584940
95Protein export_Homo sapiens_hsa030600.26908270
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24791410
97Nicotine addiction_Homo sapiens_hsa050330.24506258
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24237653
99Osteoclast differentiation_Homo sapiens_hsa043800.23991425
100Fat digestion and absorption_Homo sapiens_hsa049750.23686263

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