DOCK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.41283407
2negative regulation of cell killing (GO:0031342)6.32433112
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.32433112
4regulation of gamma-delta T cell differentiation (GO:0045586)5.66076357
5regulation of B cell receptor signaling pathway (GO:0050855)5.46492049
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46286695
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46286695
8regulation of gamma-delta T cell activation (GO:0046643)5.33208496
9antigen processing and presentation of endogenous antigen (GO:0019883)5.17016583
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.00210194
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.90877292
12positive regulation of B cell differentiation (GO:0045579)4.50117002
13B cell receptor signaling pathway (GO:0050853)4.45928787
14response to peptidoglycan (GO:0032494)4.36971636
15leukocyte aggregation (GO:0070486)4.29806615
16regulation of B cell differentiation (GO:0045577)4.28932444
17detection of other organism (GO:0098543)4.27787718
18T cell migration (GO:0072678)4.17897709
19response to interleukin-15 (GO:0070672)4.15652026
20* negative T cell selection (GO:0043383)4.14019543
21tolerance induction (GO:0002507)4.06300539
22detection of bacterium (GO:0016045)4.01969850
23interferon-gamma production (GO:0032609)4.00573861
24* negative thymic T cell selection (GO:0045060)4.00315325
25* positive thymic T cell selection (GO:0045059)3.90006911
26regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.85615568
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.83157684
28detection of molecule of bacterial origin (GO:0032490)3.77037018
29cellular response to interleukin-15 (GO:0071350)3.73930442
30microglial cell activation (GO:0001774)3.72419779
31detection of external biotic stimulus (GO:0098581)3.71954159
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70596210
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.67716017
34regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.66312321
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66045814
36negative regulation of erythrocyte differentiation (GO:0045647)3.65473137
37positive regulation by symbiont of host defense response (GO:0052509)3.64318831
38modulation by symbiont of host defense response (GO:0052031)3.64318831
39modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64318831
40modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64318831
41positive regulation by organism of defense response of other organism involved in symbiotic interact3.64318831
42modulation by symbiont of host immune response (GO:0052553)3.64318831
43NIK/NF-kappaB signaling (GO:0038061)3.63424779
44regulation of interferon-beta biosynthetic process (GO:0045357)3.59532607
45positive regulation of granulocyte differentiation (GO:0030854)3.55969835
46response to host immune response (GO:0052572)3.52133532
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52133532
48* T cell selection (GO:0045058)3.51731798
49* thymic T cell selection (GO:0045061)3.50971316
50regulation of alpha-beta T cell proliferation (GO:0046640)3.49167736
51antigen receptor-mediated signaling pathway (GO:0050851)3.43580960
52mast cell activation (GO:0045576)3.42779450
53regulation of isotype switching to IgG isotypes (GO:0048302)3.42642450
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.41981272
55* positive T cell selection (GO:0043368)3.41210806
56response to muramyl dipeptide (GO:0032495)3.36288184
57regulation of mast cell degranulation (GO:0043304)3.35623341
58detection of biotic stimulus (GO:0009595)3.34139899
59positive regulation of mast cell activation (GO:0033005)3.33977482
60negative regulation of leukocyte mediated immunity (GO:0002704)3.33406063
61T cell homeostasis (GO:0043029)3.32265570
62macrophage activation (GO:0042116)3.31809798
63mature B cell differentiation (GO:0002335)3.31281430
64* myeloid cell activation involved in immune response (GO:0002275)3.30478959
65immunoglobulin mediated immune response (GO:0016064)3.30472637
66positive regulation of isotype switching (GO:0045830)3.29295621
67leukocyte cell-cell adhesion (GO:0007159)3.28227765
68neutrophil activation involved in immune response (GO:0002283)3.27499100
69regulation of T cell tolerance induction (GO:0002664)3.27459947
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26292997
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25790886
72response to host (GO:0075136)3.25790886
73response to host defenses (GO:0052200)3.25790886
74activated T cell proliferation (GO:0050798)3.24024241
75T cell receptor signaling pathway (GO:0050852)3.21266673
76B cell homeostasis (GO:0001782)3.19836098
77T cell costimulation (GO:0031295)3.18607452
78lymphocyte homeostasis (GO:0002260)3.16663040
79B cell mediated immunity (GO:0019724)3.16117280
80lymphocyte costimulation (GO:0031294)3.13266230
81negative regulation of phagocytosis (GO:0050765)3.12204419
82cellular extravasation (GO:0045123)3.12139485
83antigen processing and presentation via MHC class Ib (GO:0002475)3.11954658
84germinal center formation (GO:0002467)3.10474942
85regulation of mast cell activation (GO:0033003)3.09841139
86regulation of mast cell activation involved in immune response (GO:0033006)3.09706481
87regulation of myeloid leukocyte mediated immunity (GO:0002886)3.09296717
88negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.09052585
89positive regulation of interleukin-2 production (GO:0032743)3.07373407
90neutrophil activation (GO:0042119)3.06836837
91neutrophil mediated immunity (GO:0002446)3.05741391
92positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05641502
93positive regulation of interferon-alpha production (GO:0032727)3.04840050
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02958509
95regulation of T cell receptor signaling pathway (GO:0050856)3.02726235
96regulation of leukocyte degranulation (GO:0043300)3.00075038
97regulation of interferon-alpha production (GO:0032647)2.95329130
98interferon-gamma-mediated signaling pathway (GO:0060333)2.94171953
99regulation of natural killer cell mediated immunity (GO:0002715)2.93564405
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93564405
101positive regulation of antigen processing and presentation (GO:0002579)2.91830381
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91350005
103response to type I interferon (GO:0034340)2.90457508
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.90215311
105negative regulation of interleukin-12 production (GO:0032695)2.90010973
106leukocyte degranulation (GO:0043299)2.89455152
107B cell proliferation (GO:0042100)2.87577437
108regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87350940
109regulation of granulocyte differentiation (GO:0030852)2.86608248
110mast cell degranulation (GO:0043303)2.85479807
111mast cell activation involved in immune response (GO:0002279)2.85479807
112cellular response to type I interferon (GO:0071357)2.85090160
113type I interferon signaling pathway (GO:0060337)2.85090160
114positive regulation of DNA recombination (GO:0045911)2.84839390
115positive regulation of mast cell degranulation (GO:0043306)2.84822220
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.84822220
117positive regulation of tolerance induction (GO:0002645)2.84305697
118regulation of interleukin-2 biosynthetic process (GO:0045076)2.83196238
119granulocyte activation (GO:0036230)2.83037601
120defense response to protozoan (GO:0042832)2.82119764
121positive regulation of humoral immune response (GO:0002922)2.81533517
122respiratory burst (GO:0045730)2.81350190
123response to protozoan (GO:0001562)2.80819462
124positive regulation of B cell activation (GO:0050871)2.80725774
125natural killer cell differentiation (GO:0001779)2.80266787
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80253080
127negative regulation of T cell mediated immunity (GO:0002710)2.80234998
128natural killer cell activation (GO:0030101)2.79062052
129regulation of antigen processing and presentation (GO:0002577)2.78718957
130positive regulation of B cell mediated immunity (GO:0002714)2.78170869
131positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78170869
132leukocyte homeostasis (GO:0001776)2.77657997
133macrophage activation involved in immune response (GO:0002281)2.76538461
134immune response-activating cell surface receptor signaling pathway (GO:0002429)2.74198282
135regulation of tolerance induction (GO:0002643)2.73734480
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73420183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.34088343
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.91757297
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.80008101
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.07820397
5E2F7_22180533_ChIP-Seq_HELA_Human4.06415063
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74737991
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.71960287
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.16913670
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.13713476
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.11909971
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.08167631
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05920208
13MYC_22102868_ChIP-Seq_BL_Human3.05556539
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05352975
15RUNX_20019798_ChIP-Seq_JUKART_Human2.95388794
16SCL_19346495_ChIP-Seq_HPC-7_Human2.95042402
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.91610384
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.82698567
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77554472
20MYB_26560356_Chip-Seq_TH2_Human2.76210214
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74712760
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67844324
23VDR_21846776_ChIP-Seq_THP-1_Human2.66967883
24MAF_26560356_Chip-Seq_TH1_Human2.50501973
25MYB_26560356_Chip-Seq_TH1_Human2.43111442
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41028239
27* SPI1_23547873_ChIP-Seq_NB4_Human2.34779976
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.29104190
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25568147
30UTX_26944678_Chip-Seq_JUKART_Human2.19471135
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12316723
32VDR_24763502_ChIP-Seq_THP-1_Human2.11788820
33* RUNX1_22412390_ChIP-Seq_EML_Mouse2.11207287
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08391604
35TCF7_22412390_ChIP-Seq_EML_Mouse2.03151882
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97904276
37* SPI1_23127762_ChIP-Seq_K562_Human1.94084020
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.84222982
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78015790
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75944334
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74392056
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71183012
43GATA3_27048872_Chip-Seq_THYMUS_Human1.70524682
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.69706645
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68455726
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67497089
47PU_27001747_Chip-Seq_BMDM_Mouse1.60633400
48* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60467822
49MAF_26560356_Chip-Seq_TH2_Human1.58601584
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54989648
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54533502
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.49566421
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46395448
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46328201
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42353444
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40733232
57KDM2B_26808549_Chip-Seq_DND41_Human1.40034214
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39322074
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38262788
60CIITA_25753668_ChIP-Seq_RAJI_Human1.33810640
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30996548
62* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30027328
63GATA1_19941826_ChIP-Seq_K562_Human1.25621340
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23382044
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22423081
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21300488
67GATA3_26560356_Chip-Seq_TH2_Human1.20540477
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19612237
69GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18965761
70GATA1_22025678_ChIP-Seq_K562_Human1.17417296
71* GATA1_19941827_ChIP-Seq_MEL_Mouse1.15781123
72* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14695100
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14455411
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13845565
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11150155
76* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10575928
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08595706
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.08212972
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07979389
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06388363
81VDR_24787735_ChIP-Seq_THP-1_Human1.06064410
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06047368
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03891196
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01097539
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98156658
86* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97126899
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96082695
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92322662
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92006996
90* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90452992
91TFEB_21752829_ChIP-Seq_HELA_Human0.84373178
92NCOR1_26117541_ChIP-Seq_K562_Human0.83452234
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81388825
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.80871191
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80243366
96VDR_23849224_ChIP-Seq_CD4+_Human0.79666000
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79215997
98SMRT_27268052_Chip-Seq_Bcells_Human0.76957982
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.76662076
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76443651
101FOXP3_21729870_ChIP-Seq_TREG_Human0.76254067
102SMAD_19615063_ChIP-ChIP_OVARY_Human0.76029201
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75784860
104ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75407891
105* GATA2_19941826_ChIP-Seq_K562_Human0.74739761
106GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74224919
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71941725
108E2F1_21310950_ChIP-Seq_MCF-7_Human0.69959238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.07526920
2MP0005671_abnormal_response_to3.55802691
3MP0001800_abnormal_humoral_immune3.33450494
4MP0003763_abnormal_thymus_physiology3.26083690
5MP0005387_immune_system_phenotype3.10387366
6MP0001790_abnormal_immune_system3.10387366
7MP0005000_abnormal_immune_tolerance2.91655785
8MP0002452_abnormal_antigen_presenting2.91131834
9* MP0000685_abnormal_immune_system2.89774946
10MP0003436_decreased_susceptibility_to2.83533396
11MP0002723_abnormal_immune_serum2.80021090
12* MP0002420_abnormal_adaptive_immunity2.74355791
13* MP0001819_abnormal_immune_cell2.71680422
14MP0003303_peritoneal_inflammation2.65591037
15MP0000569_abnormal_digit_pigmentation2.62894981
16MP0005025_abnormal_response_to2.55550792
17* MP0002398_abnormal_bone_marrow2.55512003
18MP0009785_altered_susceptibility_to2.53930679
19MP0002166_altered_tumor_susceptibility2.52387378
20* MP0002419_abnormal_innate_immunity2.51266266
21MP0006082_CNS_inflammation2.39419577
22MP0005464_abnormal_platelet_physiology2.32736805
23* MP0000716_abnormal_immune_system2.30525521
24MP0003300_gastrointestinal_ulcer2.24579808
25MP0002405_respiratory_system_inflammati2.23069941
26MP0002148_abnormal_hypersensitivity_rea2.21138301
27* MP0000689_abnormal_spleen_morphology2.16630163
28MP0001873_stomach_inflammation2.08393783
29* MP0002722_abnormal_immune_system2.07343786
30* MP0002396_abnormal_hematopoietic_system1.99712501
31MP0002006_tumorigenesis1.98066301
32MP0004808_abnormal_hematopoietic_stem1.97748645
33MP0000703_abnormal_thymus_morphology1.94687456
34MP0005174_abnormal_tail_pigmentation1.94060907
35MP0009333_abnormal_splenocyte_physiolog1.93025693
36* MP0002429_abnormal_blood_cell1.92668609
37MP0010155_abnormal_intestine_physiology1.91229207
38MP0008260_abnormal_autophagy1.91037863
39MP0004947_skin_inflammation1.88104893
40MP0004510_myositis1.76474522
41MP0001845_abnormal_inflammatory_respons1.76251595
42MP0009278_abnormal_bone_marrow1.70171270
43MP0005058_abnormal_lysosome_morphology1.70167976
44MP0003724_increased_susceptibility_to1.69796918
45MP0005451_abnormal_body_composition1.69128565
46MP0003172_abnormal_lysosome_physiology1.67874762
47MP0000465_gastrointestinal_hemorrhage1.67210523
48MP0001853_heart_inflammation1.66458196
49MP0003866_abnormal_defecation1.60736336
50MP0005397_hematopoietic_system_phenotyp1.59189579
51MP0001545_abnormal_hematopoietic_system1.59189579
52MP0003183_abnormal_peptide_metabolism1.42428403
53MP0002933_joint_inflammation1.41843518
54MP0001533_abnormal_skeleton_physiology1.37224716
55MP0005075_abnormal_melanosome_morpholog1.31739367
56MP0000858_altered_metastatic_potential1.29061120
57MP0000015_abnormal_ear_pigmentation1.27492518
58MP0005310_abnormal_salivary_gland1.27048992
59MP0008469_abnormal_protein_level1.27023280
60MP0000490_abnormal_crypts_of1.24554832
61MP0003448_altered_tumor_morphology1.21327698
62MP0004883_abnormal_blood_vessel1.20187031
63MP0001851_eye_inflammation1.12665828
64MP0010307_abnormal_tumor_latency1.10364720
65MP0003690_abnormal_glial_cell1.04861178
66MP0002019_abnormal_tumor_incidence1.01055785
67MP0008057_abnormal_DNA_replication0.99715764
68MP0002998_abnormal_bone_remodeling0.96822304
69MP0010352_gastrointestinal_tract_polyps0.96094623
70MP0003191_abnormal_cellular_cholesterol0.95870892
71MP0002138_abnormal_hepatobiliary_system0.90826670
72MP0005076_abnormal_cell_differentiation0.89467162
73MP0000371_diluted_coat_color0.86099349
74MP0002095_abnormal_skin_pigmentation0.85129518
75MP0010094_abnormal_chromosome_stability0.84024358
76MP0002132_abnormal_respiratory_system0.83470452
77MP0005164_abnormal_response_to0.81907481
78MP0003077_abnormal_cell_cycle0.80713794
79MP0003566_abnormal_cell_adhesion0.77797737
80MP0002009_preneoplasia0.77327299
81MP0000343_altered_response_to0.76859642
82MP0003221_abnormal_cardiomyocyte_apopto0.73651628
83MP0003045_fibrosis0.73032865
84* MP0009763_increased_sensitivity_to0.69833002
85MP0009764_decreased_sensitivity_to0.69136896
86MP0008004_abnormal_stomach_pH0.68361084
87MP0004381_abnormal_hair_follicle0.68292647
88MP0005023_abnormal_wound_healing0.66909627
89MP0002928_abnormal_bile_duct0.64827866
90MP0003693_abnormal_embryo_hatching0.63918636
91MP0001986_abnormal_taste_sensitivity0.63196475
92MP0005166_decreased_susceptibility_to0.62772872
93MP0008058_abnormal_DNA_repair0.62134054
94MP0000249_abnormal_blood_vessel0.61816139
95MP0001663_abnormal_digestive_system0.59975881
96MP0003828_pulmonary_edema0.59921224
97MP0008007_abnormal_cellular_replicative0.59823597
98MP0008961_abnormal_basal_metabolism0.59798062
99MP0000313_abnormal_cell_death0.59531570
100MP0002136_abnormal_kidney_physiology0.58939595
101* MP0003091_abnormal_cell_migration0.58637781
102MP0009840_abnormal_foam_cell0.58243838
103MP0003795_abnormal_bone_structure0.57255176
104MP0009115_abnormal_fat_cell0.55523376
105MP0000604_amyloidosis0.54669631
106MP0003111_abnormal_nucleus_morphology0.53348903
107* MP0009765_abnormal_xenobiotic_induced0.53199812
108MP0002277_abnormal_respiratory_mucosa0.52702280
109MP0002332_abnormal_exercise_endurance0.52246846
110MP0008874_decreased_physiological_sensi0.51888698
111MP0005390_skeleton_phenotype0.50976386
112MP0003656_abnormal_erythrocyte_physiolo0.50861451
113MP0003943_abnormal_hepatobiliary_system0.50532235
114MP0004130_abnormal_muscle_cell0.50162923
115MP0000609_abnormal_liver_physiology0.49183801
116MP0003075_altered_response_to0.47630948

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.26949057
2Recurrent bacterial skin infections (HP:0005406)4.75114004
3Eczematoid dermatitis (HP:0000976)4.58649493
4Recurrent viral infections (HP:0004429)4.57077626
5Recurrent fungal infections (HP:0002841)4.53319883
6T lymphocytopenia (HP:0005403)4.47547700
7IgM deficiency (HP:0002850)4.31147934
8Abnormality of T cell number (HP:0011839)4.26975860
9Myositis (HP:0100614)4.08159878
10Elevated erythrocyte sedimentation rate (HP:0003565)4.04149427
11Chronic otitis media (HP:0000389)3.97649420
12Recurrent bronchitis (HP:0002837)3.90766432
13Panhypogammaglobulinemia (HP:0003139)3.82634933
14Chronic mucocutaneous candidiasis (HP:0002728)3.70370036
15Recurrent cutaneous fungal infections (HP:0011370)3.70370036
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.70350926
17Agammaglobulinemia (HP:0004432)3.69622084
18Recurrent skin infections (HP:0001581)3.60066239
19Mediastinal lymphadenopathy (HP:0100721)3.58406381
20Nasal polyposis (HP:0100582)3.55642781
21Meningitis (HP:0001287)3.54404507
22Abnormality of T cells (HP:0002843)3.51936356
23Inflammation of the large intestine (HP:0002037)3.48707490
24Gastrointestinal infarctions (HP:0005244)3.48462222
25Cellulitis (HP:0100658)3.46553329
26Colitis (HP:0002583)3.38187931
27Stomatitis (HP:0010280)3.36355086
28Gastrointestinal inflammation (HP:0004386)3.35621351
29Thyroiditis (HP:0100646)3.35374521
30Abnormality of the fingertips (HP:0001211)3.28781899
31Pustule (HP:0200039)3.21884798
32Vasculitis (HP:0002633)3.21859283
33Retrobulbar optic neuritis (HP:0100654)3.18193515
34Optic neuritis (HP:0100653)3.18193515
35Orchitis (HP:0100796)3.08091785
36Abnormality of the nasal mucosa (HP:0000433)3.07842172
37Obstructive lung disease (HP:0006536)3.07081453
38Chronic obstructive pulmonary disease (HP:0006510)3.07081453
39Recurrent gram-negative bacterial infections (HP:0005420)3.05725175
40Autoimmune thrombocytopenia (HP:0001973)3.03028021
41Leukocytosis (HP:0001974)3.00001179
42Periodontitis (HP:0000704)2.98597664
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.94228207
44B lymphocytopenia (HP:0010976)2.92293175
45Abnormality of B cell number (HP:0010975)2.92293175
46Urticaria (HP:0001025)2.90834719
47Lymphopenia (HP:0001888)2.90348260
48Severe combined immunodeficiency (HP:0004430)2.89950583
49Spontaneous hematomas (HP:0007420)2.88657248
50Eosinophilia (HP:0001880)2.88441998
51Abnormality of macrophages (HP:0004311)2.87365302
52Abnormality of eosinophils (HP:0001879)2.84261781
53Prolonged bleeding time (HP:0003010)2.83500930
54Autoimmune hemolytic anemia (HP:0001890)2.81626433
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.78835657
56IgG deficiency (HP:0004315)2.77139117
57Combined immunodeficiency (HP:0005387)2.73905954
58Gastrointestinal stroma tumor (HP:0100723)2.71666058
59Pulmonary infiltrates (HP:0002113)2.71012755
60Thrombocytosis (HP:0001894)2.68015670
61Abnormality of T cell physiology (HP:0011840)2.67464540
62Gingivitis (HP:0000230)2.66561131
63Verrucae (HP:0200043)2.64604133
64Papilloma (HP:0012740)2.64604133
65Chronic diarrhea (HP:0002028)2.63937064
66Arterial thrombosis (HP:0004420)2.63186123
67Viral hepatitis (HP:0006562)2.59744091
68Granulocytopenia (HP:0001913)2.58194085
69Recurrent sinusitis (HP:0011108)2.57310746
70Epistaxis (HP:0000421)2.57133506
71Osteomyelitis (HP:0002754)2.53450072
72IgA deficiency (HP:0002720)2.53140424
73Encephalitis (HP:0002383)2.51403581
74Abnormality of liposaccharide metabolism (HP:0010968)2.46239118
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.46239118
76Abnormality of glycolipid metabolism (HP:0010969)2.46239118
77Vacuolated lymphocytes (HP:0001922)2.41396092
78Increased IgE level (HP:0003212)2.38560476
79Hemoptysis (HP:0002105)2.37602538
80Gingival bleeding (HP:0000225)2.37574291
81Abnormality of the prostate (HP:0008775)2.34602487
82Petechiae (HP:0000967)2.34460303
83Increased IgM level (HP:0003496)2.34213775
84Lymphoma (HP:0002665)2.33897973
85Pulmonary embolism (HP:0002204)2.33395811
86Hematochezia (HP:0002573)2.29780607
87Increased cerebral lipofuscin (HP:0011813)2.29517394
88Chronic sinusitis (HP:0011109)2.28218731
89Abnormal platelet function (HP:0011869)2.23238289
90Impaired platelet aggregation (HP:0003540)2.23238289
91Slow saccadic eye movements (HP:0000514)2.22680041
92Chest pain (HP:0100749)2.21521345
93Amaurosis fugax (HP:0100576)2.17783687
94Keratoconjunctivitis sicca (HP:0001097)2.17506379
95Bronchitis (HP:0012387)2.14284455
96Abnormality of the pleura (HP:0002103)2.13015578
97Fatigue (HP:0012378)2.10398249
98Interstitial pulmonary disease (HP:0006530)2.10284661
99Emphysema (HP:0002097)2.10080145
100Anorexia (HP:0002039)2.06633915
101Gangrene (HP:0100758)2.05173826
102Hypergammaglobulinemia (HP:0010702)2.04006360
103Abnormality of the peritoneum (HP:0002585)2.02941419
104Increased neuronal autofluorescent lipopigment (HP:0002074)2.02665747
105Recurrent pneumonia (HP:0006532)2.01062556
106Hypoplasia of the thymus (HP:0000778)2.00872628
107Skin ulcer (HP:0200042)2.00409477
108Abnormal platelet volume (HP:0011876)1.99576228
109Sepsis (HP:0100806)1.98739684
110Loss of speech (HP:0002371)1.97395995
111Restrictive lung disease (HP:0002091)1.97077364
112Dysostosis multiplex (HP:0000943)1.96606145
113Amyloidosis (HP:0011034)1.95482907
114Keratoconjunctivitis (HP:0001096)1.95123077
115Increased density of long bones (HP:0006392)1.92198888
116Agnosia (HP:0010524)1.90143360
117Leukopenia (HP:0001882)1.88853010
118Absent frontal sinuses (HP:0002688)1.87605266
119Acute myeloid leukemia (HP:0004808)1.87380596
120Prostate neoplasm (HP:0100787)1.86616923
121Recurrent lower respiratory tract infections (HP:0002783)1.86535437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.21281485
2TXK3.59751472
3PRPF4B3.04545525
4TYK22.89517491
5JAK32.77875851
6STK102.69705763
7KIT2.52096878
8ZAP702.49944986
9MAP3K142.44384996
10ITK2.31127651
11BLK2.18661046
12IKBKE2.13366638
13IRAK42.11891012
14JAK12.06747623
15TBK12.01871160
16GRK62.01635389
17BTK1.99559207
18SYK1.85760724
19MAP3K131.82638715
20MAP3K101.82310497
21RIPK41.79712921
22CSF1R1.74622226
23TEC1.74563761
24CSK1.66689963
25LCK1.66678087
26HCK1.64850712
27IKBKB1.59073139
28TAOK31.57045562
29EEF2K1.56635436
30FGFR41.55757231
31TGFBR21.55257578
32FES1.47528407
33FGFR31.46941093
34BMPR21.46478844
35SIK21.45299585
36MAP2K31.35544496
37IRAK31.33814781
38CLK11.30675479
39MARK31.23527181
40PIM11.23143917
41CDK121.22464161
42PKN21.17753095
43PIK3CG1.12350677
44LRRK21.11738083
45LYN1.11292451
46ERN11.02067649
47EPHB11.01338444
48NLK1.00591303
49MAP3K30.99913193
50CHUK0.99610235
51MAP3K10.98863107
52JAK20.92265145
53RPS6KA40.89754608
54CAMKK20.88196181
55TTN0.87156082
56STK40.87129357
57PRKCQ0.85899795
58MAP3K110.82795788
59TAOK10.80861583
60MARK20.80222498
61CDK40.78870658
62IRAK20.78846664
63CAMK1D0.77244225
64TRIB30.77035222
65KSR20.76122030
66PTK60.73924486
67FLT30.73413999
68YES10.72074426
69SMG10.72057732
70CDK60.70112291
71TAOK20.69467791
72NEK90.67663287
73GRK70.67357148
74CDC42BPA0.67092626
75NEK20.67015799
76NME20.65597688
77PRKCH0.65536285
78MATK0.64702146
79CAMK1G0.64202572
80CDK90.62143803
81CAMKK10.60731374
82TRPM70.60464555
83BRD40.57520909
84MAP3K70.57491095
85TNK20.56817052
86PDPK10.56722708
87PDK10.56664506
88HIPK20.55613119
89STK30.53303010
90MST40.51415427
91STK240.50330826
92MAPK70.49402467
93MAP3K60.48109175
94SGK20.47886415
95MAP3K50.45208374
96TESK20.44243384
97MELK0.43591361
98SIK30.43292213
99MAP3K20.42417282
100RPS6KC10.41564678
101RPS6KL10.41564678
102EGFR0.41035397
103PDGFRB0.39989096
104ATR0.39935596
105RET0.39178702
106MOS0.39125391
107ALK0.38928648
108EPHA30.38831064
109WNK10.38800062
110MAPK120.38653798
111MAPK40.37435566
112RAF10.36861136
113SGK30.36747082
114FYN0.35986487
115MAP3K80.35321693
116ABL10.33713483
117PASK0.33603203
118RPS6KA60.32911261
119CDK190.32196844
120FGR0.31683192
121MAPK110.31215122
122TGFBR10.29632553
123MAPKAPK20.29596041
124RIPK10.27755275
125IRAK10.27747817
126DMPK0.27594014
127IGF1R0.26058667
128CDC70.25530109
129MAPK30.24408924
130MAP2K60.23353578
131PRKCD0.22732896

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.89316404
2B cell receptor signaling pathway_Homo sapiens_hsa046622.88902115
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.66702979
4Leishmaniasis_Homo sapiens_hsa051402.63695809
5Osteoclast differentiation_Homo sapiens_hsa043802.50657213
6T cell receptor signaling pathway_Homo sapiens_hsa046602.45687563
7Measles_Homo sapiens_hsa051622.41635591
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40890446
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38834542
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.30597135
11Antigen processing and presentation_Homo sapiens_hsa046122.22068556
12Hematopoietic cell lineage_Homo sapiens_hsa046402.03495028
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79408768
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78088266
15* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73512425
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70764616
17Staphylococcus aureus infection_Homo sapiens_hsa051501.70599444
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69089010
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.63936147
20Herpes simplex infection_Homo sapiens_hsa051681.62267445
21Graft-versus-host disease_Homo sapiens_hsa053321.60365643
22Allograft rejection_Homo sapiens_hsa053301.58504103
23Toxoplasmosis_Homo sapiens_hsa051451.57180436
24Tuberculosis_Homo sapiens_hsa051521.46110782
25Influenza A_Homo sapiens_hsa051641.45860077
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45372228
27Acute myeloid leukemia_Homo sapiens_hsa052211.42071414
28* Chemokine signaling pathway_Homo sapiens_hsa040621.40494428
29Hepatitis B_Homo sapiens_hsa051611.37809411
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36925633
31Apoptosis_Homo sapiens_hsa042101.36188110
32Shigellosis_Homo sapiens_hsa051311.34727715
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.31902453
34Chronic myeloid leukemia_Homo sapiens_hsa052201.31582306
35Pertussis_Homo sapiens_hsa051331.30930930
36TNF signaling pathway_Homo sapiens_hsa046681.30419194
37Viral myocarditis_Homo sapiens_hsa054161.29003685
38Malaria_Homo sapiens_hsa051441.26739268
39Legionellosis_Homo sapiens_hsa051341.24170565
40Other glycan degradation_Homo sapiens_hsa005111.22761126
41Platelet activation_Homo sapiens_hsa046111.22248886
42Pancreatic cancer_Homo sapiens_hsa052121.15798861
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.12140487
44Epstein-Barr virus infection_Homo sapiens_hsa051691.03432655
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00513181
46Non-homologous end-joining_Homo sapiens_hsa034500.99470723
47Hepatitis C_Homo sapiens_hsa051600.94652925
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94219628
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93826784
50Viral carcinogenesis_Homo sapiens_hsa052030.93391767
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92411411
52Autoimmune thyroid disease_Homo sapiens_hsa053200.91135299
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.90761022
54Lysosome_Homo sapiens_hsa041420.89737343
55Asthma_Homo sapiens_hsa053100.88384029
56Salmonella infection_Homo sapiens_hsa051320.87796048
57HTLV-I infection_Homo sapiens_hsa051660.86925428
58Non-small cell lung cancer_Homo sapiens_hsa052230.83981387
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82054328
60Caffeine metabolism_Homo sapiens_hsa002320.79167897
61Prolactin signaling pathway_Homo sapiens_hsa049170.77583881
62Renal cell carcinoma_Homo sapiens_hsa052110.76432719
63Small cell lung cancer_Homo sapiens_hsa052220.76414733
64Base excision repair_Homo sapiens_hsa034100.76268891
65Colorectal cancer_Homo sapiens_hsa052100.76088636
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73314710
67DNA replication_Homo sapiens_hsa030300.71771404
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70909145
69VEGF signaling pathway_Homo sapiens_hsa043700.69548652
70Rheumatoid arthritis_Homo sapiens_hsa053230.65352844
71Inositol phosphate metabolism_Homo sapiens_hsa005620.64943358
72Dorso-ventral axis formation_Homo sapiens_hsa043200.64193184
73Notch signaling pathway_Homo sapiens_hsa043300.59297852
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59071778
75Endocytosis_Homo sapiens_hsa041440.55057099
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54366480
77Mismatch repair_Homo sapiens_hsa034300.54035505
78GnRH signaling pathway_Homo sapiens_hsa049120.53993512
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52825924
80p53 signaling pathway_Homo sapiens_hsa041150.52733693
81FoxO signaling pathway_Homo sapiens_hsa040680.52544035
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51007117
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.50126181
84Choline metabolism in cancer_Homo sapiens_hsa052310.49877077
85Lysine degradation_Homo sapiens_hsa003100.47990774
86African trypanosomiasis_Homo sapiens_hsa051430.47603079
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47135359
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.46766213
89Homologous recombination_Homo sapiens_hsa034400.46557939
90Phagosome_Homo sapiens_hsa041450.45561221
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45483373
92MicroRNAs in cancer_Homo sapiens_hsa052060.44012285
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43791107
94Type II diabetes mellitus_Homo sapiens_hsa049300.43309679
95Type I diabetes mellitus_Homo sapiens_hsa049400.42854562
96mTOR signaling pathway_Homo sapiens_hsa041500.42663199
97Insulin resistance_Homo sapiens_hsa049310.42311536
98Fanconi anemia pathway_Homo sapiens_hsa034600.41678685
99Glioma_Homo sapiens_hsa052140.40613835
100MAPK signaling pathway_Homo sapiens_hsa040100.39391675
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39343316
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38701193
103HIF-1 signaling pathway_Homo sapiens_hsa040660.38538388
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38381545
105Amoebiasis_Homo sapiens_hsa051460.37626660
106ErbB signaling pathway_Homo sapiens_hsa040120.36620435
107Prostate cancer_Homo sapiens_hsa052150.35987362
108Cell cycle_Homo sapiens_hsa041100.33687198
109Systemic lupus erythematosus_Homo sapiens_hsa053220.33548210
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32953398
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32604226
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.32594306
113ABC transporters_Homo sapiens_hsa020100.32443495
114Endometrial cancer_Homo sapiens_hsa052130.30971307
115Estrogen signaling pathway_Homo sapiens_hsa049150.28947164
116Long-term potentiation_Homo sapiens_hsa047200.25408336
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25229280

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