DOCK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20278573
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91195172
3synaptic vesicle maturation (GO:0016188)5.88067344
4locomotory exploration behavior (GO:0035641)5.76232673
5vocalization behavior (GO:0071625)5.59642988
6synaptic vesicle exocytosis (GO:0016079)5.39365938
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.38972222
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35142086
9glutamate secretion (GO:0014047)5.17401056
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.01545375
11regulation of glutamate receptor signaling pathway (GO:1900449)4.97568119
12regulation of synaptic vesicle exocytosis (GO:2000300)4.93830587
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.86574343
14protein localization to synapse (GO:0035418)4.79594391
15neuronal action potential propagation (GO:0019227)4.66102942
16neuron cell-cell adhesion (GO:0007158)4.63600913
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.54269883
18regulation of neuronal synaptic plasticity (GO:0048168)4.48214231
19exploration behavior (GO:0035640)4.45437900
20regulation of synapse structural plasticity (GO:0051823)4.43138687
21neurotransmitter secretion (GO:0007269)4.41346901
22synaptic transmission, glutamatergic (GO:0035249)4.40303351
23regulation of synaptic vesicle transport (GO:1902803)4.38622930
24layer formation in cerebral cortex (GO:0021819)4.34059623
25glutamate receptor signaling pathway (GO:0007215)4.33883602
26neurotransmitter-gated ion channel clustering (GO:0072578)4.28807115
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21963617
28neuron-neuron synaptic transmission (GO:0007270)4.20911515
29gamma-aminobutyric acid transport (GO:0015812)4.16763350
30dendritic spine morphogenesis (GO:0060997)4.08132542
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.04039222
32amino acid import (GO:0043090)4.00414101
33long-term memory (GO:0007616)4.00308646
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97593413
35central nervous system myelination (GO:0022010)3.96619809
36axon ensheathment in central nervous system (GO:0032291)3.96619809
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.95094132
38positive regulation of membrane potential (GO:0045838)3.94493327
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87616210
40auditory behavior (GO:0031223)3.86608214
41regulation of dendritic spine morphogenesis (GO:0061001)3.79328417
42regulation of postsynaptic membrane potential (GO:0060078)3.78876595
43cellular potassium ion homeostasis (GO:0030007)3.77198962
44potassium ion homeostasis (GO:0055075)3.67288212
45transmission of nerve impulse (GO:0019226)3.66334258
46proline transport (GO:0015824)3.66291665
47regulation of synaptic plasticity (GO:0048167)3.65475532
48potassium ion import (GO:0010107)3.61020817
49positive regulation of synapse maturation (GO:0090129)3.59639352
50neuromuscular process controlling balance (GO:0050885)3.59172604
51neurotransmitter transport (GO:0006836)3.58773463
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.58555822
53response to auditory stimulus (GO:0010996)3.58266652
54cell communication by electrical coupling (GO:0010644)3.58190573
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.57037159
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.56884239
57neuron recognition (GO:0008038)3.52874484
58prepulse inhibition (GO:0060134)3.52191849
59long-term synaptic potentiation (GO:0060291)3.49603034
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.48496129
61regulation of neurotransmitter secretion (GO:0046928)3.46932959
62negative regulation of dendrite morphogenesis (GO:0050774)3.45193956
63activation of protein kinase A activity (GO:0034199)3.44490514
64postsynaptic membrane organization (GO:0001941)3.43786257
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.43550802
66regulation of synapse maturation (GO:0090128)3.43208327
67positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42704109
68cerebellar Purkinje cell differentiation (GO:0021702)3.42398027
69presynaptic membrane assembly (GO:0097105)3.39752318
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.37274610
71synaptic vesicle endocytosis (GO:0048488)3.37114912
72positive regulation of neurotransmitter secretion (GO:0001956)3.36861496
73sodium ion export (GO:0071436)3.36106571
74cellular sodium ion homeostasis (GO:0006883)3.35787899
75positive regulation of neurotransmitter transport (GO:0051590)3.33902585
76negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33741287
77regulation of neurotransmitter levels (GO:0001505)3.32717194
78membrane hyperpolarization (GO:0060081)3.32486692
79regulation of ARF protein signal transduction (GO:0032012)3.32124580
80axonal fasciculation (GO:0007413)3.29838767
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29734858
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27579578
83dendrite morphogenesis (GO:0048813)3.26351317
84membrane depolarization (GO:0051899)3.25464050
85presynaptic membrane organization (GO:0097090)3.25191153
86regulation of neurotransmitter transport (GO:0051588)3.24165616
87neuromuscular process controlling posture (GO:0050884)3.23935393
88acidic amino acid transport (GO:0015800)3.23411887
89glycine transport (GO:0015816)3.23233683
90regulation of dendritic spine development (GO:0060998)3.21722941
91membrane depolarization during action potential (GO:0086010)3.21214204
92mechanosensory behavior (GO:0007638)3.21118386
93response to histamine (GO:0034776)3.20023855
94regulation of vesicle fusion (GO:0031338)3.19604731
95neuromuscular synaptic transmission (GO:0007274)3.18198461
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16855617
97neuronal ion channel clustering (GO:0045161)3.16350499
98L-amino acid import (GO:0043092)3.16187042
99establishment of mitochondrion localization (GO:0051654)3.15512427
100learning (GO:0007612)3.15251709
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13754248
102synapse assembly (GO:0007416)3.11718897
103behavioral fear response (GO:0001662)3.09734164
104behavioral defense response (GO:0002209)3.09734164
105cerebellar granule cell differentiation (GO:0021707)3.09219426
106neuromuscular process (GO:0050905)3.08489592
107positive regulation of dendritic spine development (GO:0060999)3.06716118
108positive regulation of synaptic transmission (GO:0050806)3.06187799
109neurotransmitter uptake (GO:0001504)3.04501073
110dendritic spine organization (GO:0097061)3.03865639
111adult walking behavior (GO:0007628)3.03727512
112innervation (GO:0060384)3.03529293
113regulation of synaptic transmission (GO:0050804)3.01724469
114behavioral response to cocaine (GO:0048148)3.01720393
115vesicle transport along microtubule (GO:0047496)3.01600967
116startle response (GO:0001964)3.01147565
117detection of calcium ion (GO:0005513)3.00645949
118regulation of voltage-gated calcium channel activity (GO:1901385)2.99939087
119cell communication involved in cardiac conduction (GO:0086065)2.99821650
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99774638
121synaptic transmission (GO:0007268)2.98912390
122serotonin metabolic process (GO:0042428)2.96342609
123cell differentiation in hindbrain (GO:0021533)2.96230462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98326755
2GBX2_23144817_ChIP-Seq_PC3_Human3.61213104
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07321055
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00443240
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00300883
6REST_21632747_ChIP-Seq_MESCs_Mouse2.72908479
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.72768329
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65880268
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65880268
10DROSHA_22980978_ChIP-Seq_HELA_Human2.60585325
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55716639
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52755048
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47698569
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47164258
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.43025324
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42375762
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39953732
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.29710864
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20692765
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.19004193
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.18884416
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.16830015
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.14989685
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98650067
25AR_21572438_ChIP-Seq_LNCaP_Human1.98345471
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97136035
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92236664
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88259732
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86863672
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85690658
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81045683
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77908417
33TAF15_26573619_Chip-Seq_HEK293_Human1.72637324
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.64882553
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63258205
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.52189582
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46355880
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43494956
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38671269
40* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34432800
41SOX2_21211035_ChIP-Seq_LN229_Gbm1.34091741
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.32707319
43* P300_19829295_ChIP-Seq_ESCs_Human1.32322839
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.31299245
45ZNF274_21170338_ChIP-Seq_K562_Hela1.29845636
46* STAT3_23295773_ChIP-Seq_U87_Human1.29258119
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27467330
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26494059
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.25658252
50AR_25329375_ChIP-Seq_VCAP_Human1.23386538
51AR_19668381_ChIP-Seq_PC3_Human1.22891200
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22292995
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21749618
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21699724
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.21493884
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20319901
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19896164
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17956104
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16645403
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16501066
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14927842
62* TCF4_23295773_ChIP-Seq_U87_Human1.14390600
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13900996
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13799054
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13647157
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13526970
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.11556033
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10550843
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10066009
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08806168
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.08610579
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.08388389
73RNF2_27304074_Chip-Seq_NSC_Mouse1.06999859
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06231577
75IGF1R_20145208_ChIP-Seq_DFB_Human1.05826735
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05563303
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05068366
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04237137
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04112928
80AHR_22903824_ChIP-Seq_MCF-7_Human1.03649804
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03362661
82TP53_16413492_ChIP-PET_HCT116_Human1.03278694
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02538697
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02494979
85TET1_21490601_ChIP-Seq_MESCs_Mouse1.02045668
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01166855
87KDM2B_26808549_Chip-Seq_K562_Human1.01091634
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99081518
89RUNX2_22187159_ChIP-Seq_PCA_Human0.98198737
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97677583
91SOX9_26525672_Chip-Seq_HEART_Mouse0.97623197
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.97497488
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97359001
94LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96822621
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95781029
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93519954
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93519954
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.93218006
99* SMAD3_21741376_ChIP-Seq_ESCs_Human0.92988788
100FUS_26573619_Chip-Seq_HEK293_Human0.92849404
101CTCF_27219007_Chip-Seq_Bcells_Human0.92647259
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92641466
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92635352
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91599564
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89746977
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89635725
107* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89070639
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88074000
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88060951
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87289638
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87288867
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86638011
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86611484
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84819549
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84162663
116KDM2B_26808549_Chip-Seq_REH_Human0.82273303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.69959046
2MP0003880_abnormal_central_pattern4.82387806
3MP0003635_abnormal_synaptic_transmissio4.25986299
4MP0004270_analgesia3.89200008
5MP0009745_abnormal_behavioral_response3.55780772
6* MP0002063_abnormal_learning/memory/cond3.40229296
7MP0002822_catalepsy3.39548071
8MP0009046_muscle_twitch3.33740365
9MP0002064_seizures3.26533101
10MP0001968_abnormal_touch/_nociception3.05495839
11MP0005423_abnormal_somatic_nervous3.04823685
12MP0002572_abnormal_emotion/affect_behav2.88621945
13MP0001486_abnormal_startle_reflex2.74357670
14MP0002272_abnormal_nervous_system2.69785815
15MP0002734_abnormal_mechanical_nocicepti2.66854099
16MP0002736_abnormal_nociception_after2.32152002
17MP0001501_abnormal_sleep_pattern2.31479161
18MP0002735_abnormal_chemical_nociception2.15788385
19MP0001440_abnormal_grooming_behavior2.12901812
20MP0002733_abnormal_thermal_nociception2.02377179
21MP0008569_lethality_at_weaning1.99126331
22MP0001970_abnormal_pain_threshold1.97177643
23* MP0002067_abnormal_sensory_capabilities1.95997063
24MP0005386_behavior/neurological_phenoty1.84846081
25MP0004924_abnormal_behavior1.84846081
26MP0000778_abnormal_nervous_system1.83309548
27MP0003329_amyloid_beta_deposits1.80868785
28MP0002184_abnormal_innervation1.79559627
29MP0002557_abnormal_social/conspecific_i1.79423049
30MP0009780_abnormal_chondrocyte_physiolo1.75774362
31* MP0004811_abnormal_neuron_physiology1.73558577
32MP0005646_abnormal_pituitary_gland1.72917208
33MP0002909_abnormal_adrenal_gland1.65044474
34MP0001984_abnormal_olfaction1.62757303
35MP0003879_abnormal_hair_cell1.62193758
36MP0004858_abnormal_nervous_system1.61265943
37MP0001529_abnormal_vocalization1.55964946
38* MP0000955_abnormal_spinal_cord1.51170413
39MP0004885_abnormal_endolymph1.50900939
40MP0003123_paternal_imprinting1.50277567
41* MP0002066_abnormal_motor_capabilities/c1.44474983
42MP0002882_abnormal_neuron_morphology1.43746293
43MP0003787_abnormal_imprinting1.42133065
44MP0006276_abnormal_autonomic_nervous1.40435918
45MP0003633_abnormal_nervous_system1.39831447
46MP0001502_abnormal_circadian_rhythm1.30777743
47MP0005645_abnormal_hypothalamus_physiol1.30464848
48MP0004142_abnormal_muscle_tone1.28082233
49MP0000569_abnormal_digit_pigmentation1.22833596
50MP0001905_abnormal_dopamine_level1.21659525
51MP0003631_nervous_system_phenotype1.20689394
52MP0001188_hyperpigmentation1.15455555
53* MP0002152_abnormal_brain_morphology1.12337320
54MP0008877_abnormal_DNA_methylation1.09534416
55MP0008872_abnormal_physiological_respon1.02641964
56MP0001177_atelectasis1.02331160
57MP0000920_abnormal_myelination1.00948873
58MP0005551_abnormal_eye_electrophysiolog0.98452252
59MP0004742_abnormal_vestibular_system0.97745575
60* MP0002229_neurodegeneration0.96998718
61MP0008874_decreased_physiological_sensi0.94556301
62MP0004145_abnormal_muscle_electrophysio0.93532457
63MP0002069_abnormal_eating/drinking_beha0.92472290
64MP0005409_darkened_coat_color0.92010084
65MP0003632_abnormal_nervous_system0.90544693
66MP0002638_abnormal_pupillary_reflex0.87888891
67MP0003634_abnormal_glial_cell0.87596281
68MP0001346_abnormal_lacrimal_gland0.87170193
69MP0000751_myopathy0.86520300
70MP0008961_abnormal_basal_metabolism0.86156611
71MP0003121_genomic_imprinting0.84674897
72MP0003122_maternal_imprinting0.84654026
73MP0004085_abnormal_heartbeat0.82845926
74MP0003075_altered_response_to0.79753426
75MP0001963_abnormal_hearing_physiology0.79653912
76MP0000631_abnormal_neuroendocrine_gland0.77925412
77MP0001348_abnormal_lacrimal_gland0.77694871
78MP0000566_synostosis0.76799469
79MP0005394_taste/olfaction_phenotype0.76710063
80MP0005499_abnormal_olfactory_system0.76710063
81MP0000604_amyloidosis0.76401688
82MP0003283_abnormal_digestive_organ0.76096946
83MP0004147_increased_porphyrin_level0.74445630
84MP0002090_abnormal_vision0.73597587
85MP0005535_abnormal_body_temperature0.73166838
86* MP0002752_abnormal_somatic_nervous0.72893030
87MP0010386_abnormal_urinary_bladder0.72429815
88MP0001485_abnormal_pinna_reflex0.71191608
89MP0000013_abnormal_adipose_tissue0.69542207
90MP0000579_abnormal_nail_morphology0.68983819
91* MP0003690_abnormal_glial_cell0.68847062
92MP0003137_abnormal_impulse_conducting0.67215429
93MP0003938_abnormal_ear_development0.65943275
94MP0005167_abnormal_blood-brain_barrier0.64916930
95MP0000026_abnormal_inner_ear0.63782000
96MP0010234_abnormal_vibrissa_follicle0.62226274
97MP0004215_abnormal_myocardial_fiber0.60859798
98MP0002653_abnormal_ependyma_morphology0.60281602
99MP0004130_abnormal_muscle_cell0.59073523
100MP0005623_abnormal_meninges_morphology0.58155452
101MP0001986_abnormal_taste_sensitivity0.58014187
102MP0003861_abnormal_nervous_system0.57783363
103MP0001299_abnormal_eye_distance/0.57364171
104MP0001664_abnormal_digestion0.55614703
105MP0001943_abnormal_respiration0.55315843
106MP0004484_altered_response_of0.54497027
107MP0010769_abnormal_survival0.54446116
108MP0004510_myositis0.53339124
109MP0005171_absent_coat_pigmentation0.53244565
110MP0004043_abnormal_pH_regulation0.52609572
111MP0002876_abnormal_thyroid_physiology0.52466265
112MP0010770_preweaning_lethality0.52419458
113MP0002082_postnatal_lethality0.52419458
114MP0010768_mortality/aging0.51171150
115MP0003956_abnormal_body_size0.49892865
116MP0006292_abnormal_olfactory_placode0.46777619

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78726356
2Myokymia (HP:0002411)7.27706720
3Focal seizures (HP:0007359)5.92718003
4Epileptic encephalopathy (HP:0200134)4.98430027
5Visual hallucinations (HP:0002367)4.87414004
6Febrile seizures (HP:0002373)4.48708957
7Atonic seizures (HP:0010819)4.42183682
8Progressive cerebellar ataxia (HP:0002073)4.34369284
9Action tremor (HP:0002345)4.09285759
10Absence seizures (HP:0002121)4.03368933
11Broad-based gait (HP:0002136)3.91643623
12Generalized tonic-clonic seizures (HP:0002069)3.83050524
13Dialeptic seizures (HP:0011146)3.73689198
14Gaze-evoked nystagmus (HP:0000640)3.71536372
15Poor eye contact (HP:0000817)3.66189484
16Ankle clonus (HP:0011448)3.63638945
17Supranuclear gaze palsy (HP:0000605)3.59898835
18Dysdiadochokinesis (HP:0002075)3.38493826
19Impaired vibration sensation in the lower limbs (HP:0002166)3.36911468
20Urinary bladder sphincter dysfunction (HP:0002839)3.34428868
21Dysmetria (HP:0001310)3.30730044
22Impaired social interactions (HP:0000735)3.27325888
23Abnormal social behavior (HP:0012433)3.27325888
24Hyperventilation (HP:0002883)3.27002866
25Depression (HP:0000716)3.19221901
26Truncal ataxia (HP:0002078)3.15189936
27Postural instability (HP:0002172)3.07092585
28Mutism (HP:0002300)3.02330801
29Scanning speech (HP:0002168)3.00550877
30Anxiety (HP:0000739)2.98045430
31Papilledema (HP:0001085)2.94350015
32Impaired smooth pursuit (HP:0007772)2.87515835
33Abnormal eating behavior (HP:0100738)2.86977084
34Urinary urgency (HP:0000012)2.85841182
35Genetic anticipation (HP:0003743)2.85669782
36Spastic gait (HP:0002064)2.85134224
37Torticollis (HP:0000473)2.79693538
38Amblyopia (HP:0000646)2.78639443
39Abnormality of the lower motor neuron (HP:0002366)2.71935092
40Intention tremor (HP:0002080)2.71766941
41Drooling (HP:0002307)2.70801906
42Excessive salivation (HP:0003781)2.70801906
43Hemiparesis (HP:0001269)2.68846748
44Tetraplegia (HP:0002445)2.66609420
45Neurofibrillary tangles (HP:0002185)2.64751860
46Akinesia (HP:0002304)2.62635843
47Diplopia (HP:0000651)2.58564296
48Abnormality of binocular vision (HP:0011514)2.58564296
49Stereotypic behavior (HP:0000733)2.58246693
50Cerebral hypomyelination (HP:0006808)2.56753136
51Progressive inability to walk (HP:0002505)2.55159208
52Abnormality of ocular smooth pursuit (HP:0000617)2.53610159
53Dysmetric saccades (HP:0000641)2.53157371
54Abnormality of the corticospinal tract (HP:0002492)2.52566192
55Focal dystonia (HP:0004373)2.52413562
56Epileptiform EEG discharges (HP:0011182)2.51710129
57Cerebral inclusion bodies (HP:0100314)2.48175377
58Hemiplegia (HP:0002301)2.47798334
59Bradykinesia (HP:0002067)2.45469153
60Absent speech (HP:0001344)2.45397349
61Termporal pattern (HP:0011008)2.44275272
62Insidious onset (HP:0003587)2.44275272
63EEG with generalized epileptiform discharges (HP:0011198)2.40612859
64Impaired vibratory sensation (HP:0002495)2.35288346
65Spastic tetraparesis (HP:0001285)2.32787456
66Sleep apnea (HP:0010535)2.32138962
67Megalencephaly (HP:0001355)2.32099750
68Annular pancreas (HP:0001734)2.31779906
69Status epilepticus (HP:0002133)2.31382539
70Hypsarrhythmia (HP:0002521)2.29298262
71Fetal akinesia sequence (HP:0001989)2.28198285
72Craniofacial dystonia (HP:0012179)2.27898516
73Lower limb muscle weakness (HP:0007340)2.27816277
74Peripheral hypomyelination (HP:0007182)2.23172905
75Apathy (HP:0000741)2.21060015
76Limb dystonia (HP:0002451)2.20760072
77Blue irides (HP:0000635)2.18771754
78Inability to walk (HP:0002540)2.17814632
79Delusions (HP:0000746)2.17147335
80Pheochromocytoma (HP:0002666)2.13454312
81Ventricular fibrillation (HP:0001663)2.13384558
82Morphological abnormality of the pyramidal tract (HP:0002062)2.11573480
83Generalized myoclonic seizures (HP:0002123)2.10159339
84Pointed chin (HP:0000307)2.08019399
85Clonus (HP:0002169)2.06629918
86Incomplete penetrance (HP:0003829)2.04204954
87Gait ataxia (HP:0002066)2.01922288
88Resting tremor (HP:0002322)2.00281869
89Neuronal loss in central nervous system (HP:0002529)1.99880701
90Abnormality of saccadic eye movements (HP:0000570)1.99625902
91Inappropriate behavior (HP:0000719)1.97045027
92Amyotrophic lateral sclerosis (HP:0007354)1.96658999
93Lower limb amyotrophy (HP:0007210)1.95577166
94Diminished motivation (HP:0000745)1.94388063
95Obstructive sleep apnea (HP:0002870)1.93830910
96Insomnia (HP:0100785)1.92888494
97Polyphagia (HP:0002591)1.92825998
98Protruding tongue (HP:0010808)1.92387324
99Split foot (HP:0001839)1.87437157
100Spastic tetraplegia (HP:0002510)1.87071882
101Abnormal EKG (HP:0003115)1.83450172
102Choreoathetosis (HP:0001266)1.81806152
103Rapidly progressive (HP:0003678)1.81378213
104Abnormality of salivation (HP:0100755)1.80717100
105Agitation (HP:0000713)1.80147618
106Ankyloglossia (HP:0010296)1.79511185
107CNS hypomyelination (HP:0003429)1.79453851
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.78127577
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78127577
110Aqueductal stenosis (HP:0002410)1.77241977
111Aplasia involving bones of the extremities (HP:0009825)1.77011922
112Aplasia involving bones of the upper limbs (HP:0009823)1.77011922
113Aplasia of the phalanges of the hand (HP:0009802)1.77011922
114Rigidity (HP:0002063)1.76487958
115Specific learning disability (HP:0001328)1.76062421
116Increased circulating renin level (HP:0000848)1.75339193
117Bundle branch block (HP:0011710)1.73407672
118Lower limb asymmetry (HP:0100559)1.73107449
119Hypoplasia of the corpus callosum (HP:0002079)1.70411594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.72077877
2NTRK34.44450818
3MAP3K93.85306339
4MARK13.27857877
5MAP3K43.09887466
6DAPK22.66730566
7MAP2K72.58465443
8MINK12.51777564
9NTRK22.29017209
10PAK62.27368250
11KSR22.06831192
12PRKD31.95337857
13TNIK1.94821707
14RIPK41.93426406
15CAMKK11.90456650
16NTRK11.88766906
17MAP2K41.87216781
18CASK1.68353265
19MAP3K121.66735874
20CDK51.59882424
21KSR11.58105183
22DAPK11.57424296
23CDK191.51338740
24PRPF4B1.42193974
25MAPK131.38351613
26STK381.37460137
27PLK21.26829983
28SIK21.24634778
29PNCK1.24310057
30CAMKK21.21002109
31TYRO31.19574563
32FES1.17132097
33PRKCG1.16447618
34MAP3K21.14327014
35GRK51.13167758
36ARAF1.11498773
37TAOK11.09801234
38MAP3K131.08053257
39UHMK11.03440694
40SGK2231.01948852
41SGK4941.01948852
42STK110.97383674
43CAMK2A0.96495679
44OXSR10.95598620
45PHKG20.95007732
46PHKG10.95007732
47CDK180.90586412
48CAMK10.89796301
49CDK150.89601439
50LATS20.85090082
51PINK10.84378820
52CDK140.84178330
53SGK20.84045985
54PRKCH0.83451080
55MARK20.83119958
56BMPR20.81268980
57RET0.81244190
58CAMK2B0.80561930
59CDK11A0.77436628
60RAF10.77240849
61CSNK1G20.76358464
62SGK10.74784147
63SGK30.73685295
64ALK0.68423739
65PTK2B0.67976459
66DYRK1A0.65801946
67PDK10.65185423
68NEK60.64550581
69PDPK10.62266191
70PAK30.61953341
71WNK10.58877940
72TNK20.58303098
73CCNB10.57591278
74CAMK1D0.57510570
75BRAF0.54258808
76CAMK1G0.52239237
77RPS6KA30.51474050
78MAP3K10.50651338
79LMTK20.50310246
80PRKCZ0.48262827
81MAP3K60.47099464
82FYN0.46288733
83PRKCE0.45880668
84CAMK2D0.45798817
85AKT30.44948647
86MAPK100.44849955
87CDC42BPA0.44842156
88CAMK40.44136551
89CAMK2G0.43398171
90RIPK10.40876387
91DAPK30.38859328
92PKN10.38651202
93ROCK20.38453724
94MAP3K70.38315436
95DYRK20.37775036
96CSNK1E0.37146367
97STK390.36517772
98FGR0.35573818
99FGFR20.35405028
100CSNK1D0.34474709
101GSK3B0.33931819
102MAP3K110.33821399
103MAPKAPK50.33513776
104PRKCB0.33308083
105PRKG10.32939914
106ERBB20.32802350
107SCYL20.32735202
108BRSK10.32288270
109NEK10.31579067
110MAP2K10.31152085
111MAPK80.30625390
112MAPK120.30434618
113WNK30.29386375
114PRKDC0.27687905
115ROCK10.27201199
116PRKCA0.26893088

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77551554
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22277526
3Olfactory transduction_Homo sapiens_hsa047402.90225926
4Circadian entrainment_Homo sapiens_hsa047132.78505731
5GABAergic synapse_Homo sapiens_hsa047272.74948701
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71402446
7Glutamatergic synapse_Homo sapiens_hsa047242.70954854
8Long-term potentiation_Homo sapiens_hsa047202.69501065
9Morphine addiction_Homo sapiens_hsa050322.62127170
10Amphetamine addiction_Homo sapiens_hsa050312.50002799
11Salivary secretion_Homo sapiens_hsa049702.21174786
12Dopaminergic synapse_Homo sapiens_hsa047282.19620099
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09535829
14Insulin secretion_Homo sapiens_hsa049111.99017594
15Cholinergic synapse_Homo sapiens_hsa047251.96098665
16Gastric acid secretion_Homo sapiens_hsa049711.89013897
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83279585
18Taste transduction_Homo sapiens_hsa047421.77579762
19Cocaine addiction_Homo sapiens_hsa050301.75107796
20Renin secretion_Homo sapiens_hsa049241.74997036
21Long-term depression_Homo sapiens_hsa047301.74124872
22Oxytocin signaling pathway_Homo sapiens_hsa049211.68440541
23Serotonergic synapse_Homo sapiens_hsa047261.67172231
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65986462
25Calcium signaling pathway_Homo sapiens_hsa040201.61775314
26GnRH signaling pathway_Homo sapiens_hsa049121.45918614
27Gap junction_Homo sapiens_hsa045401.38206984
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36724926
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35203112
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33836692
31cAMP signaling pathway_Homo sapiens_hsa040241.32962465
32Collecting duct acid secretion_Homo sapiens_hsa049661.28177135
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20659470
34Type II diabetes mellitus_Homo sapiens_hsa049301.20432048
35Axon guidance_Homo sapiens_hsa043601.16475154
36Estrogen signaling pathway_Homo sapiens_hsa049151.14142792
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12525855
38Glioma_Homo sapiens_hsa052141.11305917
39Nitrogen metabolism_Homo sapiens_hsa009101.09043231
40Vitamin B6 metabolism_Homo sapiens_hsa007501.09010932
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08271541
42ErbB signaling pathway_Homo sapiens_hsa040121.06895678
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06719017
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03601249
45Melanogenesis_Homo sapiens_hsa049161.02365784
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96739766
47Dorso-ventral axis formation_Homo sapiens_hsa043200.94322094
48Oocyte meiosis_Homo sapiens_hsa041140.90917117
49Phototransduction_Homo sapiens_hsa047440.90889252
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89309568
51Pancreatic secretion_Homo sapiens_hsa049720.87786049
52Cardiac muscle contraction_Homo sapiens_hsa042600.86269409
53Vibrio cholerae infection_Homo sapiens_hsa051100.76420016
54Thyroid hormone synthesis_Homo sapiens_hsa049180.76248642
55Choline metabolism in cancer_Homo sapiens_hsa052310.74654351
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73251551
57MAPK signaling pathway_Homo sapiens_hsa040100.72540191
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71106311
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70694006
60Dilated cardiomyopathy_Homo sapiens_hsa054140.70205550
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65285904
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62186608
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61420424
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60815853
65Ras signaling pathway_Homo sapiens_hsa040140.60797604
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.60040570
67VEGF signaling pathway_Homo sapiens_hsa043700.59197196
68Rap1 signaling pathway_Homo sapiens_hsa040150.58152245
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.57417348
70Alcoholism_Homo sapiens_hsa050340.55470200
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54985696
72Inositol phosphate metabolism_Homo sapiens_hsa005620.54513756
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53872155
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52135636
75mTOR signaling pathway_Homo sapiens_hsa041500.50087431
76Glucagon signaling pathway_Homo sapiens_hsa049220.49725304
77Circadian rhythm_Homo sapiens_hsa047100.49304061
78Type I diabetes mellitus_Homo sapiens_hsa049400.47101995
79Endocytosis_Homo sapiens_hsa041440.46992846
80Bile secretion_Homo sapiens_hsa049760.46640018
81Fatty acid biosynthesis_Homo sapiens_hsa000610.46191289
82Hippo signaling pathway_Homo sapiens_hsa043900.44568098
83Endometrial cancer_Homo sapiens_hsa052130.44106061
84Non-small cell lung cancer_Homo sapiens_hsa052230.43792614
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43731472
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43018744
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42903451
88Ovarian steroidogenesis_Homo sapiens_hsa049130.42699338
89Renal cell carcinoma_Homo sapiens_hsa052110.42671609
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42600091
91Wnt signaling pathway_Homo sapiens_hsa043100.42239222
92Tight junction_Homo sapiens_hsa045300.39618086
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38768652
94Chemokine signaling pathway_Homo sapiens_hsa040620.36911960
95Prion diseases_Homo sapiens_hsa050200.36774115
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34821111
97African trypanosomiasis_Homo sapiens_hsa051430.33849532
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33414747
99Insulin signaling pathway_Homo sapiens_hsa049100.33016120
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32907689
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32582119
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.31319514
103Hedgehog signaling pathway_Homo sapiens_hsa043400.30369585
104beta-Alanine metabolism_Homo sapiens_hsa004100.29416470
105AMPK signaling pathway_Homo sapiens_hsa041520.28830590
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25993786
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25437413
108Arginine and proline metabolism_Homo sapiens_hsa003300.25000425
109Histidine metabolism_Homo sapiens_hsa003400.23834602
110Colorectal cancer_Homo sapiens_hsa052100.23537352
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22611764
112Mineral absorption_Homo sapiens_hsa049780.20708017

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