DOCK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.55644241
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.08948469
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05808211
4ionotropic glutamate receptor signaling pathway (GO:0035235)4.89024292
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80542230
6vocalization behavior (GO:0071625)4.79412783
7regulation of glutamate receptor signaling pathway (GO:1900449)4.54705493
8synaptic vesicle maturation (GO:0016188)4.54125507
9glutamate receptor signaling pathway (GO:0007215)4.37007717
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30139829
11exploration behavior (GO:0035640)4.18059415
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11446531
13glutamate secretion (GO:0014047)4.06025488
14regulation of neuronal synaptic plasticity (GO:0048168)4.05918196
15synaptic vesicle exocytosis (GO:0016079)4.05696342
16synaptic transmission, glutamatergic (GO:0035249)4.02379605
17protein localization to synapse (GO:0035418)4.01787869
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93384474
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.92675343
20cellular response to ethanol (GO:0071361)3.91561409
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87747252
22regulation of synapse structural plasticity (GO:0051823)3.80832339
23neurotransmitter-gated ion channel clustering (GO:0072578)3.80418539
24neuron-neuron synaptic transmission (GO:0007270)3.79206834
25neuronal action potential propagation (GO:0019227)3.74770893
26long-term memory (GO:0007616)3.73136046
27regulation of synaptic vesicle exocytosis (GO:2000300)3.71186804
28regulation of excitatory postsynaptic membrane potential (GO:0060079)3.70412718
29macrophage activation involved in immune response (GO:0002281)3.70055964
30neuron cell-cell adhesion (GO:0007158)3.68814328
31regulation of dendritic spine morphogenesis (GO:0061001)3.60970241
32dendritic spine morphogenesis (GO:0060997)3.58637918
33gamma-aminobutyric acid transport (GO:0015812)3.57414653
34neurotransmitter secretion (GO:0007269)3.54473427
35cellular potassium ion homeostasis (GO:0030007)3.53390979
36regulation of synaptic vesicle transport (GO:1902803)3.49324410
37negative regulation of interleukin-12 production (GO:0032695)3.47817545
38adenosine receptor signaling pathway (GO:0001973)3.46433633
39regulation of postsynaptic membrane potential (GO:0060078)3.46041992
40regulation of synaptic plasticity (GO:0048167)3.44262035
41neuron recognition (GO:0008038)3.43154701
42long-term synaptic potentiation (GO:0060291)3.41499853
43L-amino acid import (GO:0043092)3.39409799
44detection of molecule of bacterial origin (GO:0032490)3.36091844
45layer formation in cerebral cortex (GO:0021819)3.29547368
46neuromuscular process controlling balance (GO:0050885)3.29223385
47regulation of mononuclear cell migration (GO:0071675)3.28569262
48synaptic vesicle endocytosis (GO:0048488)3.26642744
49axonal fasciculation (GO:0007413)3.26379528
50transmission of nerve impulse (GO:0019226)3.23693362
51positive regulation of synapse maturation (GO:0090129)3.23301927
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23089122
53positive regulation of membrane potential (GO:0045838)3.23046530
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21993943
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.20160907
56proline transport (GO:0015824)3.20095989
57dendrite morphogenesis (GO:0048813)3.17771844
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.17559150
59regulation of chemokine-mediated signaling pathway (GO:0070099)3.15839477
60sodium ion export (GO:0071436)3.13238112
61regulation of macrophage chemotaxis (GO:0010758)3.07571554
62regulation of dendritic spine development (GO:0060998)3.07473120
63behavioral fear response (GO:0001662)3.03868124
64behavioral defense response (GO:0002209)3.03868124
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02525623
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02296716
67response to peptidoglycan (GO:0032494)3.02095796
68T-helper 1 type immune response (GO:0042088)3.00196532
69dendritic spine organization (GO:0097061)2.98598008
70membrane depolarization (GO:0051899)2.98275476
71cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98063195
72regulation of female receptivity (GO:0045924)2.97195899
73cerebellar Purkinje cell differentiation (GO:0021702)2.97041749
74macrophage activation (GO:0042116)2.94797488
75nerve growth factor signaling pathway (GO:0038180)2.94792183
76long term synaptic depression (GO:0060292)2.94328273
77innervation (GO:0060384)2.92794118
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92031570
79cell communication by electrical coupling (GO:0010644)2.89212674
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88665023
81response to auditory stimulus (GO:0010996)2.88490139
82membrane depolarization during action potential (GO:0086010)2.88407483
83positive regulation of heat generation (GO:0031652)2.88396884
84learning (GO:0007612)2.88381085
85positive regulation of dendritic spine development (GO:0060999)2.88199176
86activation of protein kinase A activity (GO:0034199)2.88050203
87protein localization to endosome (GO:0036010)2.86968438
88negative regulation of synaptic transmission, GABAergic (GO:0032229)2.86590277
89neurotransmitter transport (GO:0006836)2.85841036
90vesicle transport along microtubule (GO:0047496)2.84925361
91response to histamine (GO:0034776)2.84607489
92retina vasculature morphogenesis in camera-type eye (GO:0061299)2.83107281
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82343851
94fear response (GO:0042596)2.81876431
95auditory behavior (GO:0031223)2.81666199
96behavioral response to cocaine (GO:0048148)2.81528835
97prepulse inhibition (GO:0060134)2.81291383
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.79262881
99regulation of fever generation (GO:0031620)2.77996848
100chemosensory behavior (GO:0007635)2.77930246
101regulation of neurotransmitter levels (GO:0001505)2.77665998
102neuronal ion channel clustering (GO:0045161)2.76846027
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75411240
104regulation of neurotransmitter secretion (GO:0046928)2.75229519
105regulation of glutamate secretion (GO:0014048)2.74972109
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.72629861
107positive regulation of synaptic transmission (GO:0050806)2.72336849
108neuromuscular process controlling posture (GO:0050884)2.70245554
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.69998872
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69956758
111regulation of synaptic transmission (GO:0050804)2.69436869
112regulation of ARF protein signal transduction (GO:0032012)2.69248945
113positive regulation of neurotransmitter secretion (GO:0001956)2.68776066
114establishment of nucleus localization (GO:0040023)2.68471881
115positive regulation of cellular amide metabolic process (GO:0034250)2.68092045
116neuromuscular process (GO:0050905)2.67555770
117amino acid import (GO:0043090)2.67282070
118cellular response to thyroid hormone stimulus (GO:0097067)2.65278568
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64947376
120modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64947376
121positive regulation by organism of defense response of other organism involved in symbiotic interact2.64947376
122modulation by symbiont of host immune response (GO:0052553)2.64947376
123positive regulation by symbiont of host defense response (GO:0052509)2.64947376
124modulation by symbiont of host defense response (GO:0052031)2.64947376
125cellular sodium ion homeostasis (GO:0006883)2.64826206
126cerebellar granule cell differentiation (GO:0021707)2.63814383
127microglial cell activation (GO:0001774)2.63518518
128germinal center formation (GO:0002467)2.62682306
129female mating behavior (GO:0060180)2.61961609
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61835992
131negative regulation of amino acid transport (GO:0051956)2.61198675
132positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.54238195
133sarcoplasmic reticulum calcium ion transport (GO:0070296)2.52064843
134regulation of vitamin D biosynthetic process (GO:0060556)2.51596047
135positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46499053
136substrate-dependent cell migration (GO:0006929)2.44925036
137response to manganese ion (GO:0010042)2.44494029
138glycosphingolipid catabolic process (GO:0046479)2.41982806
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39978545
140apoptotic cell clearance (GO:0043277)2.39803599
141monocyte chemotaxis (GO:0002548)2.39161487
142regulation of membrane protein ectodomain proteolysis (GO:0051043)2.36078386
143cellular response to nerve growth factor stimulus (GO:1990090)2.33392528
144response to nerve growth factor (GO:1990089)2.33392528
145cortical actin cytoskeleton organization (GO:0030866)2.32498090
146regulation of heat generation (GO:0031650)2.30479510
147regulation of cholesterol storage (GO:0010885)2.29343455
148positive regulation of acute inflammatory response (GO:0002675)2.27762796
149positive regulation of macrophage cytokine production (GO:0060907)2.26021406
150regulation of interferon-beta biosynthetic process (GO:0045357)2.25719121
151endothelium development (GO:0003158)2.25665956
152positive regulation of phagocytosis (GO:0050766)2.25256072
153negative regulation of interleukin-17 production (GO:0032700)2.24654020
154neuron remodeling (GO:0016322)2.24100785
155positive regulation of toll-like receptor signaling pathway (GO:0034123)2.23242359
156cell adhesion mediated by integrin (GO:0033627)2.21758893
157oligosaccharide catabolic process (GO:0009313)2.21172194
158positive regulation of type 2 immune response (GO:0002830)2.21008970
159regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.19550336
160regulation of axon regeneration (GO:0048679)2.18264263
161regulation of neuron projection regeneration (GO:0070570)2.18264263
162regulation of cytokine secretion involved in immune response (GO:0002739)2.18218680
163Rap protein signal transduction (GO:0032486)2.17708011
164cortical cytoskeleton organization (GO:0030865)2.17481638
165regulation of vascular endothelial growth factor production (GO:0010574)2.16326970
166regulation of T-helper 2 cell differentiation (GO:0045628)2.15499939
167response to muramyl dipeptide (GO:0032495)2.15478270
168regulation of myeloid leukocyte mediated immunity (GO:0002886)2.13641131
169negative regulation of vascular permeability (GO:0043116)2.13304119
170negative regulation of inclusion body assembly (GO:0090084)2.12519329
171positive regulation of nitric oxide biosynthetic process (GO:0045429)2.12174810
172positive regulation of chemokine secretion (GO:0090197)2.10825838
173positive regulation of leukocyte degranulation (GO:0043302)2.10700157
174glycolipid catabolic process (GO:0019377)2.09384975
175Notch signaling involved in heart development (GO:0061314)2.08954772
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.08797876
177Rac protein signal transduction (GO:0016601)2.08348786
178regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.07652854
179regulation of apoptotic cell clearance (GO:2000425)2.07257052
180regulation of interferon-alpha production (GO:0032647)2.05696063
181regulation of NFAT protein import into nucleus (GO:0051532)2.05037366
182cAMP biosynthetic process (GO:0006171)2.04177562
183macroautophagy (GO:0016236)2.03605146
184regulation of nitric oxide biosynthetic process (GO:0045428)2.03444640
185positive regulation of cholesterol efflux (GO:0010875)2.01297621
186negative regulation of blood vessel endothelial cell migration (GO:0043537)2.00632515
187regulation of T-helper 1 cell differentiation (GO:0045625)2.00097073
188positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.99909560
189regulation of interleukin-8 biosynthetic process (GO:0045414)1.98524949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05712979
2GBX2_23144817_ChIP-Seq_PC3_Human3.53484975
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.26094422
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83933471
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83181836
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71210021
7* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49838130
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48513200
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48513200
10DROSHA_22980978_ChIP-Seq_HELA_Human2.48112879
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45698166
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35276084
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.34498881
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33338926
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30749225
16REST_21632747_ChIP-Seq_MESCs_Mouse2.26482974
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24938659
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24317035
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.16721245
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.06617766
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.03712073
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.92656114
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.90563584
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.89338643
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88598514
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86444145
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84060610
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81915682
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81228162
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.80915772
31* REST_18959480_ChIP-ChIP_MESCs_Mouse1.76967141
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74467213
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74221298
34AR_21572438_ChIP-Seq_LNCaP_Human1.70871334
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70777508
36SMAD4_21799915_ChIP-Seq_A2780_Human1.62214925
37VDR_24787735_ChIP-Seq_THP-1_Human1.59874858
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59237863
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54781911
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53962152
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51910394
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50310596
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50083633
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49175453
45* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44796042
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.44554357
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.43913965
48TP53_16413492_ChIP-PET_HCT116_Human1.43727421
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.41379032
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40843493
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40732646
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40463660
53TAF15_26573619_Chip-Seq_HEK293_Human1.40388730
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38585402
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.36697357
56GATA1_22025678_ChIP-Seq_K562_Human1.36545932
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35987058
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35647799
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35219468
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34726395
61P300_19829295_ChIP-Seq_ESCs_Human1.34426567
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32482329
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30204630
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29628430
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28605325
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28344600
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.28303310
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28270925
69AR_25329375_ChIP-Seq_VCAP_Human1.27803420
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26743421
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.25855268
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.25594059
73AHR_22903824_ChIP-Seq_MCF-7_Human1.24637740
74ZNF274_21170338_ChIP-Seq_K562_Hela1.24526853
75* STAT3_23295773_ChIP-Seq_U87_Human1.23769902
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23219536
77STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22858289
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22369408
79AR_19668381_ChIP-Seq_PC3_Human1.20573030
80SPI1_23127762_ChIP-Seq_K562_Human1.19445053
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18974943
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18424121
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18182661
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17115874
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16567448
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15808216
87NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15749879
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14591490
89* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14338559
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14024325
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13706605
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13051217
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.12979067
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12807876
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12072674
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10729737
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10154235
98* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09569510
99TCF4_23295773_ChIP-Seq_U87_Human1.08764924
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.08128465
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06713541
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.05077353
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03834931
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03756965
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03654549
106TP53_18474530_ChIP-ChIP_U2OS_Human1.03253481
107RXR_22108803_ChIP-Seq_LS180_Human1.03066675
108KDM2B_26808549_Chip-Seq_K562_Human1.01412571
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01267052
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00689512
111* RING1B_27294783_Chip-Seq_NPCs_Mouse0.99737785
112RUNX2_22187159_ChIP-Seq_PCA_Human0.99626481
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99147374
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98749266
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98145647
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97671616
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97066604
118BCAT_22108803_ChIP-Seq_LS180_Human0.95870755
119CJUN_26792858_Chip-Seq_BT549_Human0.95719336
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95510937
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95510117
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95398763
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94591422
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94580456
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94024644
126* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93883674
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93395288
128RUNX_20019798_ChIP-Seq_JUKART_Human0.92797646
129IGF1R_20145208_ChIP-Seq_DFB_Human0.92273634
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91661035
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.91591781
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.91531084
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.90356106
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90339111
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90329420
136* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90177381
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89714604
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89714604
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89573004
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89359689
141POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89359689
142KDM2B_26808549_Chip-Seq_REH_Human0.88869602
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88313225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.17617774
2MP0003303_peritoneal_inflammation5.13896512
3MP0003880_abnormal_central_pattern4.77478350
4MP0003635_abnormal_synaptic_transmissio4.17452224
5MP0009745_abnormal_behavioral_response3.49936965
6MP0004270_analgesia3.48975373
7MP0002063_abnormal_learning/memory/cond3.45811644
8MP0002064_seizures3.18312741
9MP0003724_increased_susceptibility_to3.15990154
10MP0002822_catalepsy3.02276253
11MP0001968_abnormal_touch/_nociception2.84756938
12MP0002572_abnormal_emotion/affect_behav2.81436228
13MP0009046_muscle_twitch2.80568377
14MP0006082_CNS_inflammation2.56279553
15MP0001486_abnormal_startle_reflex2.52503602
16MP0002272_abnormal_nervous_system2.44196333
17MP0005058_abnormal_lysosome_morphology2.42786527
18MP0002736_abnormal_nociception_after2.38075798
19MP0001501_abnormal_sleep_pattern2.37747763
20MP0001440_abnormal_grooming_behavior2.28879482
21MP0010368_abnormal_lymphatic_system2.23784553
22MP0005423_abnormal_somatic_nervous2.21523806
23MP0003300_gastrointestinal_ulcer2.21341266
24MP0002332_abnormal_exercise_endurance2.18060965
25MP0002734_abnormal_mechanical_nocicepti2.14472512
26MP0002735_abnormal_chemical_nociception2.11747502
27MP0009840_abnormal_foam_cell2.10440308
28MP0000343_altered_response_to2.09067974
29MP0009780_abnormal_chondrocyte_physiolo2.05083621
30MP0003195_calcinosis1.94480245
31MP0006054_spinal_hemorrhage1.93764128
32MP0003329_amyloid_beta_deposits1.92979625
33MP0003828_pulmonary_edema1.92653678
34MP0002067_abnormal_sensory_capabilities1.85976733
35MP0008004_abnormal_stomach_pH1.83651350
36MP0004858_abnormal_nervous_system1.83561513
37MP0000778_abnormal_nervous_system1.79802990
38MP0003091_abnormal_cell_migration1.74521373
39MP0002419_abnormal_innate_immunity1.73281834
40MP0003436_decreased_susceptibility_to1.69579485
41MP0002998_abnormal_bone_remodeling1.69073912
42MP0002733_abnormal_thermal_nociception1.67448623
43MP0000569_abnormal_digit_pigmentation1.65415077
44MP0008569_lethality_at_weaning1.64354298
45MP0009764_decreased_sensitivity_to1.64069958
46MP0001970_abnormal_pain_threshold1.63283863
47MP0002557_abnormal_social/conspecific_i1.61013381
48MP0003690_abnormal_glial_cell1.60454523
49MP0004811_abnormal_neuron_physiology1.59645583
50MP0009785_altered_susceptibility_to1.58683270
51MP0002909_abnormal_adrenal_gland1.58431412
52MP0002148_abnormal_hypersensitivity_rea1.57982910
53MP0002184_abnormal_innervation1.55428501
54MP0004924_abnormal_behavior1.54954154
55MP0005386_behavior/neurological_phenoty1.54954154
56MP0003633_abnormal_nervous_system1.54035176
57MP0001533_abnormal_skeleton_physiology1.48780985
58MP0009278_abnormal_bone_marrow1.45730611
59MP0004885_abnormal_endolymph1.43998550
60MP0000955_abnormal_spinal_cord1.35876020
61MP0001879_abnormal_lymphatic_vessel1.35589963
62MP0003075_altered_response_to1.34353907
63MP0003879_abnormal_hair_cell1.33123499
64MP0005167_abnormal_blood-brain_barrier1.32458936
65MP0002066_abnormal_motor_capabilities/c1.31518330
66MP0003631_nervous_system_phenotype1.29743603
67MP0005646_abnormal_pituitary_gland1.29279332
68MP0005451_abnormal_body_composition1.29107681
69MP0005164_abnormal_response_to1.27425708
70MP0000604_amyloidosis1.24798205
71MP0002882_abnormal_neuron_morphology1.23956160
72MP0001790_abnormal_immune_system1.20973564
73MP0005387_immune_system_phenotype1.20973564
74MP0003172_abnormal_lysosome_physiology1.20914946
75MP0005397_hematopoietic_system_phenotyp1.19577776
76MP0001545_abnormal_hematopoietic_system1.19577776
77MP0003787_abnormal_imprinting1.18208096
78MP0004883_abnormal_blood_vessel1.18142345
79MP0008874_decreased_physiological_sensi1.17890988
80MP0005025_abnormal_response_to1.15152974
81MP0003448_altered_tumor_morphology1.14088764
82MP0006276_abnormal_autonomic_nervous1.13451448
83MP0001502_abnormal_circadian_rhythm1.12578387
84MP0001915_intracranial_hemorrhage1.11000961
85MP0000465_gastrointestinal_hemorrhage1.10550702
86MP0005000_abnormal_immune_tolerance1.07015651
87MP0005165_increased_susceptibility_to1.07003224
88MP0004145_abnormal_muscle_electrophysio1.06926563
89MP0001529_abnormal_vocalization1.06470454
90MP0003705_abnormal_hypodermis_morpholog1.05576620
91MP0005409_darkened_coat_color1.04455224
92MP0003950_abnormal_plasma_membrane1.04181891
93MP0001177_atelectasis1.03022737
94MP0004510_myositis1.02832349
95MP0000920_abnormal_myelination1.02390365
96MP0002152_abnormal_brain_morphology1.01887675
97MP0003453_abnormal_keratinocyte_physiol1.01366469
98MP0001905_abnormal_dopamine_level1.00902074
99MP0000249_abnormal_blood_vessel1.00616635
100MP0003632_abnormal_nervous_system0.99154173
101MP0004142_abnormal_muscle_tone0.98566296
102MP0008961_abnormal_basal_metabolism0.98521263
103MP0005310_abnormal_salivary_gland0.98135044
104MP0005535_abnormal_body_temperature0.97852036
105MP0000767_abnormal_smooth_muscle0.96891358
106MP0001984_abnormal_olfaction0.94575956
107MP0004085_abnormal_heartbeat0.94543793
108MP0004484_altered_response_of0.94470363
109MP0001188_hyperpigmentation0.93044273
110MP0002069_abnormal_eating/drinking_beha0.92223976
111MP0004272_abnormal_basement_membrane0.91667204
112MP0005464_abnormal_platelet_physiology0.91112408
113MP0003279_aneurysm0.90164826
114MP0004947_skin_inflammation0.89228635
115MP0010352_gastrointestinal_tract_polyps0.88796869
116MP0003634_abnormal_glial_cell0.88238141
117MP0005671_abnormal_response_to0.87020686
118MP0002090_abnormal_vision0.86924331
119MP0002229_neurodegeneration0.86735126
120MP0005645_abnormal_hypothalamus_physiol0.85793705
121MP0002452_abnormal_antigen_presenting0.85100641
122MP0002168_other_aberrant_phenotype0.85048390
123MP0002877_abnormal_melanocyte_morpholog0.84560503
124MP0005085_abnormal_gallbladder_physiolo0.84492138
125MP0004130_abnormal_muscle_cell0.81436903
126MP0002723_abnormal_immune_serum0.81253242
127MP0003566_abnormal_cell_adhesion0.81147067
128MP0008872_abnormal_physiological_respon0.80679082
129MP0002837_dystrophic_cardiac_calcinosis0.79794938
130MP0002896_abnormal_bone_mineralization0.78631684
131MP0005388_respiratory_system_phenotype0.77503471
132MP0002133_abnormal_respiratory_system0.77503471
133MP0004215_abnormal_myocardial_fiber0.77305562
134MP0000751_myopathy0.77063654
135MP0003045_fibrosis0.77040395
136MP0001835_abnormal_antigen_presentation0.76043645
137MP0004742_abnormal_vestibular_system0.75396914
138MP0008469_abnormal_protein_level0.73988708
139MP0005023_abnormal_wound_healing0.72029339
140MP0003656_abnormal_erythrocyte_physiolo0.71790859
141MP0001845_abnormal_inflammatory_respons0.70587662
142MP0003137_abnormal_impulse_conducting0.69790724
143MP0001963_abnormal_hearing_physiology0.65725166
144MP0005623_abnormal_meninges_morphology0.64571048
145MP0005360_urolithiasis0.64402054
146MP0005166_decreased_susceptibility_to0.61299447
147MP0010329_abnormal_lipoprotein_level0.60082284
148MP0005595_abnormal_vascular_smooth0.59818171
149MP0005551_abnormal_eye_electrophysiolog0.56957668
150MP0010386_abnormal_urinary_bladder0.55918856
151MP0000013_abnormal_adipose_tissue0.55813019
152MP0004233_abnormal_muscle_weight0.54698344
153MP0005187_abnormal_penis_morphology0.51729604
154MP0003283_abnormal_digestive_organ0.51233416
155MP0002139_abnormal_hepatobiliary_system0.50133729
156MP0005365_abnormal_bile_salt0.50037940
157MP0002752_abnormal_somatic_nervous0.48964849
158MP0003191_abnormal_cellular_cholesterol0.47993026
159MP0001664_abnormal_digestion0.46086653
160MP0010769_abnormal_survival0.45929711
161MP0003252_abnormal_bile_duct0.45905992

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.53544903
2Myokymia (HP:0002411)6.30869043
3Focal seizures (HP:0007359)5.67631779
4Abnormality of liposaccharide metabolism (HP:0010968)4.95919111
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.95919111
6Abnormality of glycolipid metabolism (HP:0010969)4.95919111
7Systemic lupus erythematosus (HP:0002725)4.82375188
8Glomerulonephritis (HP:0000099)4.74434601
9Visual hallucinations (HP:0002367)4.43260260
10Action tremor (HP:0002345)4.36358483
11Atonic seizures (HP:0010819)4.31648536
12Epileptic encephalopathy (HP:0200134)4.25854354
13Progressive cerebellar ataxia (HP:0002073)4.20492550
14Febrile seizures (HP:0002373)4.08232817
15Disinhibition (HP:0000734)3.95020701
16Absence seizures (HP:0002121)3.93025250
17Hyperventilation (HP:0002883)3.79171539
18Dialeptic seizures (HP:0011146)3.73922669
19Generalized tonic-clonic seizures (HP:0002069)3.69602808
20Supranuclear gaze palsy (HP:0000605)3.69455981
21Increased cerebral lipofuscin (HP:0011813)3.40060821
22Dysdiadochokinesis (HP:0002075)3.38876460
23Dysmetria (HP:0001310)3.36415217
24Broad-based gait (HP:0002136)3.35729605
25Gaze-evoked nystagmus (HP:0000640)3.31479702
26Poor eye contact (HP:0000817)3.31067926
27Cerebral inclusion bodies (HP:0100314)3.30858265
28Apathy (HP:0000741)3.26836478
29Postural instability (HP:0002172)3.25865630
30Impaired vibration sensation in the lower limbs (HP:0002166)3.20661457
31Abnormal social behavior (HP:0012433)3.20425900
32Impaired social interactions (HP:0000735)3.20425900
33Hematochezia (HP:0002573)3.14667940
34Neurofibrillary tangles (HP:0002185)3.14336045
35Depression (HP:0000716)2.97695928
36Diminished motivation (HP:0000745)2.97042325
37Cerebral aneurysm (HP:0004944)2.96534829
38Mutism (HP:0002300)2.95381442
39Myocardial infarction (HP:0001658)2.94913377
40Drooling (HP:0002307)2.94710687
41Excessive salivation (HP:0003781)2.94710687
42Dysostosis multiplex (HP:0000943)2.92629217
43Truncal ataxia (HP:0002078)2.92610988
44Abnormality of the lower motor neuron (HP:0002366)2.90842460
45Urinary bladder sphincter dysfunction (HP:0002839)2.90388213
46Vacuolated lymphocytes (HP:0001922)2.89125940
47Intention tremor (HP:0002080)2.88593070
48Abnormality of complement system (HP:0005339)2.84558832
49Status epilepticus (HP:0002133)2.82769036
50Amblyopia (HP:0000646)2.80124887
51Diplopia (HP:0000651)2.79969829
52Abnormality of binocular vision (HP:0011514)2.79969829
53Hemiparesis (HP:0001269)2.78864502
54Genetic anticipation (HP:0003743)2.77833043
55Agnosia (HP:0010524)2.77684471
56Anxiety (HP:0000739)2.77157067
57Abnormality of the vasculature of the conjunctiva (HP:0008054)2.75986983
58Scanning speech (HP:0002168)2.75343293
59Loss of speech (HP:0002371)2.74436720
60Hemiplegia (HP:0002301)2.70113880
61Recurrent gram-negative bacterial infections (HP:0005420)2.69416479
62Interstitial pulmonary disease (HP:0006530)2.68609564
63Abnormality of macrophages (HP:0004311)2.65248838
64Nuclear cataract (HP:0100018)2.63130962
65Axonal loss (HP:0003447)2.60621486
66Esophageal varix (HP:0002040)2.60162581
67Retrobulbar optic neuritis (HP:0100654)2.58096043
68Optic neuritis (HP:0100653)2.58096043
69Impaired smooth pursuit (HP:0007772)2.56421154
70Upper motor neuron abnormality (HP:0002127)2.55157521
71Dysmetric saccades (HP:0000641)2.51181705
72Orchitis (HP:0100796)2.50475612
73Abnormal eating behavior (HP:0100738)2.48480793
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47041422
75Recurrent bacterial skin infections (HP:0005406)2.44618137
76Torticollis (HP:0000473)2.43676774
77Nephritis (HP:0000123)2.43347903
78Spontaneous hematomas (HP:0007420)2.43229300
79Stereotypic behavior (HP:0000733)2.41240763
80Amyloidosis (HP:0011034)2.40894772
81Ankle clonus (HP:0011448)2.40618743
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40261015
83Abnormality of polysaccharide metabolism (HP:0011012)2.40261015
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40261015
85Absent speech (HP:0001344)2.37986781
86Epileptiform EEG discharges (HP:0011182)2.36229530
87Impaired vibratory sensation (HP:0002495)2.35849244
88Eczematoid dermatitis (HP:0000976)2.34552937
89Urinary glycosaminoglycan excretion (HP:0003541)2.33862853
90Mucopolysacchariduria (HP:0008155)2.33862853
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.32672175
92Bradykinesia (HP:0002067)2.32132470
93Urinary urgency (HP:0000012)2.31453983
94Neuronal loss in central nervous system (HP:0002529)2.30361317
95Abnormality of ocular smooth pursuit (HP:0000617)2.28739988
96Spastic gait (HP:0002064)2.28352063
97Focal dystonia (HP:0004373)2.26503037
98Abnormality of the corticospinal tract (HP:0002492)2.22117203
99Lower limb asymmetry (HP:0100559)2.21918758
100Conjunctival telangiectasia (HP:0000524)2.21371670
101Annular pancreas (HP:0001734)2.19516753
102Termporal pattern (HP:0011008)2.18511563
103Insidious onset (HP:0003587)2.18511563
104EEG with generalized epileptiform discharges (HP:0011198)2.16433747
105Recurrent abscess formation (HP:0002722)2.15458345
106Generalized myoclonic seizures (HP:0002123)2.14851000
107Dementia (HP:0000726)2.12591909
108Blue irides (HP:0000635)2.12498188
109Peripheral demyelination (HP:0011096)2.11757717
110Cerebral hemorrhage (HP:0001342)2.10159931
111Memory impairment (HP:0002354)2.05779319
112Onion bulb formation (HP:0003383)2.04778678
113Autoimmune thrombocytopenia (HP:0001973)2.04404065
114Global brain atrophy (HP:0002283)2.04159988
115Hypsarrhythmia (HP:0002521)2.04078147
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03098949
117Abnormality of salivation (HP:0100755)2.01081683
118Difficulty running (HP:0009046)2.00447545
119Aqueductal stenosis (HP:0002410)1.99724908
120Lower limb muscle weakness (HP:0007340)1.99722286
121Mediastinal lymphadenopathy (HP:0100721)1.99090183
122Papilledema (HP:0001085)1.98325506
123Rapidly progressive (HP:0003678)1.97990441
124Megalencephaly (HP:0001355)1.97342342
125Progressive inability to walk (HP:0002505)1.96407182
126Incomplete penetrance (HP:0003829)1.95357186
127Craniofacial dystonia (HP:0012179)1.94124028
128Gait ataxia (HP:0002066)1.93631205
129Segmental peripheral demyelination/remyelination (HP:0003481)1.90437988
130Tetraparesis (HP:0002273)1.89934855
131Pointed chin (HP:0000307)1.86947748
132Psychosis (HP:0000709)1.86668425
133Portal hypertension (HP:0001409)1.86574841
134Abnormality of the periventricular white matter (HP:0002518)1.84748188
135Decreased motor nerve conduction velocity (HP:0003431)1.84392252
136Lower limb amyotrophy (HP:0007210)1.83491029
137Abnormality of saccadic eye movements (HP:0000570)1.83329404
138Myositis (HP:0100614)1.82969966
139Exotropia (HP:0000577)1.82061235
140Adactyly (HP:0009776)1.79237216
141Arterial tortuosity (HP:0005116)1.79165174
142Rigidity (HP:0002063)1.77322040
143Ventricular fibrillation (HP:0001663)1.77150905
144Personality changes (HP:0000751)1.77066998
145Frequent falls (HP:0002359)1.76406767
146Clumsiness (HP:0002312)1.75794998
147Thickened helices (HP:0000391)1.74671535
148Inability to walk (HP:0002540)1.73158031
149Hammertoe (HP:0001765)1.72871393
150Generalized hypopigmentation of hair (HP:0011358)1.72110430
151Fair hair (HP:0002286)1.70335602
152Hemoptysis (HP:0002105)1.70324069
153Gingivitis (HP:0000230)1.70188623
154Pathologic fracture (HP:0002756)1.68835926
155Vertigo (HP:0002321)1.68749997
156Keratoconjunctivitis sicca (HP:0001097)1.67857435
157Increased CSF protein (HP:0002922)1.66702247
158Complement deficiency (HP:0004431)1.66642009
159Obstructive sleep apnea (HP:0002870)1.66273757
160Inappropriate behavior (HP:0000719)1.66098388
161Anosmia (HP:0000458)1.65887432
162Urinary incontinence (HP:0000020)1.65840693
163Retinal atrophy (HP:0001105)1.64849032
164Protruding tongue (HP:0010808)1.64614807
165Spastic tetraparesis (HP:0001285)1.64034768
166Spinal muscular atrophy (HP:0007269)1.63256907
167Abnormality of the hepatic vasculature (HP:0006707)1.61543624
168Aplasia of the phalanges of the hand (HP:0009802)1.61420184
169Aplasia involving bones of the extremities (HP:0009825)1.61420184

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.63291745
2NTRK34.58271541
3TIE14.06594608
4TGFBR23.82553251
5IRAK33.49924883
6MAP3K93.35881957
7RIPK42.95256259
8MAP3K42.56395326
9DAPK22.41501848
10MINK12.34290748
11KSR22.17877750
12MARK12.02824432
13TNIK2.02125172
14PAK61.92791540
15BLK1.89203637
16MAP3K141.86734707
17MOS1.86587750
18MAP2K71.84687545
19MAP2K41.82500347
20KSR11.78889918
21NTRK21.78034373
22NTRK11.76414206
23FES1.73644892
24PRKD31.73319919
25CAMKK11.72948532
26MAP3K131.72877332
27SIK21.58040369
28CSK1.54177548
29PLK21.44748158
30EPHA31.41109125
31DAPK11.40674119
32PTK2B1.40640223
33CDK51.39737073
34MATK1.37100978
35TYRO31.35704867
36STK381.32889876
37TYK21.31697251
38JAK11.25930954
39PRKCG1.23446889
40GRK51.23325051
41CASK1.22734679
42PRPF4B1.22118871
43PNCK1.16146261
44ARAF1.11619047
45CAMK1G1.09770082
46ACVR1B1.08841319
47MAP3K121.07205348
48PDGFRB1.07081778
49MAP3K21.06320791
50CAMK2A1.05173862
51FGR1.02095378
52SGK2230.99813539
53SGK4940.99813539
54CAMK2B0.98716044
55SGK20.97434244
56TBK10.96401699
57RAF10.95306226
58CAMKK20.94970085
59BMPR20.92356376
60JAK20.90477119
61SGK30.89315271
62CAMK10.89178246
63MAPK130.89030801
64CSF1R0.87954697
65RET0.84393801
66IRAK20.83789682
67PDPK10.80937881
68SGK10.80299522
69DMPK0.80197108
70PRKCH0.79749496
71STK110.77497625
72MAP3K110.76158332
73PDK10.75649688
74RIPK10.74112048
75IRAK10.72089295
76FGFR20.72005150
77IRAK40.72001091
78MAP3K70.70545996
79JAK30.66431096
80MARK20.64704238
81CAMK40.63449712
82ADRBK20.61738095
83TTN0.60728544
84CDK180.60502912
85PAK30.60481010
86MAP3K30.60391740
87FGFR30.59861300
88PRKAA20.59155934
89PHKG20.58722652
90PHKG10.58722652
91PRKCE0.58460141
92CDK150.58163834
93MAPK70.57262472
94IKBKE0.57171800
95FYN0.56777659
96PRKCZ0.56386835
97CDK60.56230354
98ZAP700.55990583
99FER0.55199910
100CDK140.54451224
101RPS6KA20.53851424
102RPS6KA30.52129985
103PINK10.51983029
104MAP2K30.51777239
105OXSR10.51771592
106TAOK20.51626918
107UHMK10.51385388
108CAMK1D0.51010351
109CHUK0.50907973
110YES10.50099220
111MAPK120.48964158
112LATS20.48959331
113MAP3K50.47921994
114SIK30.47882988
115CAMK2D0.47744444
116TAOK10.47696738
117DYRK1A0.47574979
118EPHB20.47229130
119MAP2K10.47114720
120NEK60.46777682
121MAP3K10.46764959
122ROCK20.46642813
123NEK90.46337790
124CDK11A0.45578234
125EGFR0.45562998
126CAMK2G0.45093742
127GRK70.44953511
128MAPK100.44517583
129ICK0.41792888
130WNK10.41645046
131CSNK1G20.41172552
132INSRR0.40950268
133EPHB10.40611137
134ABL20.40412596
135PRKCQ0.39460634
136INSR0.39230887
137PDGFRA0.38967446
138PKN10.38333774
139FGFR40.37354321
140DDR20.36942748
141CDK190.36691417
142GSK3A0.36650782
143CDC42BPA0.36374311
144MAP3K60.34788468
145PTK20.34221332

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41893414
2Long-term potentiation_Homo sapiens_hsa047202.62633217
3Glutamatergic synapse_Homo sapiens_hsa047242.54233362
4Circadian entrainment_Homo sapiens_hsa047132.48600948
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42663769
6GABAergic synapse_Homo sapiens_hsa047272.31064807
7Synaptic vesicle cycle_Homo sapiens_hsa047212.28218451
8Amphetamine addiction_Homo sapiens_hsa050312.24143050
9Staphylococcus aureus infection_Homo sapiens_hsa051502.23553140
10Olfactory transduction_Homo sapiens_hsa047402.22077426
11Morphine addiction_Homo sapiens_hsa050322.18654695
12Salivary secretion_Homo sapiens_hsa049702.13557856
13Nitrogen metabolism_Homo sapiens_hsa009102.09678583
14Osteoclast differentiation_Homo sapiens_hsa043801.94361728
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93443856
16Pertussis_Homo sapiens_hsa051331.88602447
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86998807
18Dopaminergic synapse_Homo sapiens_hsa047281.85382160
19Lysosome_Homo sapiens_hsa041421.80706574
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79487132
21Other glycan degradation_Homo sapiens_hsa005111.74321362
22Gastric acid secretion_Homo sapiens_hsa049711.71293476
23Long-term depression_Homo sapiens_hsa047301.70615706
24Cholinergic synapse_Homo sapiens_hsa047251.69214897
25Renin secretion_Homo sapiens_hsa049241.65123130
26Insulin secretion_Homo sapiens_hsa049111.63612559
27Leishmaniasis_Homo sapiens_hsa051401.58543817
28Oxytocin signaling pathway_Homo sapiens_hsa049211.58298860
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57141308
30Calcium signaling pathway_Homo sapiens_hsa040201.56369837
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.55191549
32Malaria_Homo sapiens_hsa051441.54428704
33Rheumatoid arthritis_Homo sapiens_hsa053231.52876715
34Tuberculosis_Homo sapiens_hsa051521.50570846
35Taste transduction_Homo sapiens_hsa047421.49714099
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43440809
37Legionellosis_Homo sapiens_hsa051341.43059532
38Serotonergic synapse_Homo sapiens_hsa047261.40977025
39GnRH signaling pathway_Homo sapiens_hsa049121.39317072
40TNF signaling pathway_Homo sapiens_hsa046681.38749974
41Cocaine addiction_Homo sapiens_hsa050301.37245767
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35450709
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30494518
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28582107
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27220729
46Salmonella infection_Homo sapiens_hsa051321.26749541
47Type II diabetes mellitus_Homo sapiens_hsa049301.25170928
48cAMP signaling pathway_Homo sapiens_hsa040241.24613652
49Gap junction_Homo sapiens_hsa045401.21095133
50Phagosome_Homo sapiens_hsa041451.20673501
51Amoebiasis_Homo sapiens_hsa051461.18328615
52Glioma_Homo sapiens_hsa052141.17497130
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16660017
54Axon guidance_Homo sapiens_hsa043601.13928877
55Toxoplasmosis_Homo sapiens_hsa051451.13698079
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12438919
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11768340
58Estrogen signaling pathway_Homo sapiens_hsa049151.08306139
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06379266
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05125340
61Arginine biosynthesis_Homo sapiens_hsa002201.03274242
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02956508
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.02675402
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02219827
65Bile secretion_Homo sapiens_hsa049761.00585188
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99188360
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.95249232
68Choline metabolism in cancer_Homo sapiens_hsa052310.92051699
69Collecting duct acid secretion_Homo sapiens_hsa049660.91218516
70ErbB signaling pathway_Homo sapiens_hsa040120.91075789
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.89643871
72Melanogenesis_Homo sapiens_hsa049160.88449621
73Influenza A_Homo sapiens_hsa051640.86331766
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86162787
75Dorso-ventral axis formation_Homo sapiens_hsa043200.86013037
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83094655
77Pancreatic secretion_Homo sapiens_hsa049720.82038812
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81271861
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80720708
80Prolactin signaling pathway_Homo sapiens_hsa049170.78499079
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78029723
82HIF-1 signaling pathway_Homo sapiens_hsa040660.76226196
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76177278
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75034509
85Dilated cardiomyopathy_Homo sapiens_hsa054140.72183818
86VEGF signaling pathway_Homo sapiens_hsa043700.71677693
87Thyroid hormone synthesis_Homo sapiens_hsa049180.71602354
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.71557516
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70782506
90African trypanosomiasis_Homo sapiens_hsa051430.69446711
91B cell receptor signaling pathway_Homo sapiens_hsa046620.68962383
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68243654
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.68226463
94Hepatitis C_Homo sapiens_hsa051600.66158788
95Prion diseases_Homo sapiens_hsa050200.63930840
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63703028
97* Rap1 signaling pathway_Homo sapiens_hsa040150.63374932
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.62526638
99Focal adhesion_Homo sapiens_hsa045100.62465838
100Proteoglycans in cancer_Homo sapiens_hsa052050.61405249
101Glucagon signaling pathway_Homo sapiens_hsa049220.60620817
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.59978841
103Adherens junction_Homo sapiens_hsa045200.58544055
104MAPK signaling pathway_Homo sapiens_hsa040100.58402077
105mTOR signaling pathway_Homo sapiens_hsa041500.57552933
106PPAR signaling pathway_Homo sapiens_hsa033200.57180425
107Bladder cancer_Homo sapiens_hsa052190.56523723
108Ras signaling pathway_Homo sapiens_hsa040140.55343461
109Sphingolipid metabolism_Homo sapiens_hsa006000.55088421
110Inositol phosphate metabolism_Homo sapiens_hsa005620.53415198
111Mineral absorption_Homo sapiens_hsa049780.53134519
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52814850
113Hepatitis B_Homo sapiens_hsa051610.52189849
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.52054844
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51886392
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.50993784
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50448231
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48375647
119Cardiac muscle contraction_Homo sapiens_hsa042600.46100849
120Non-small cell lung cancer_Homo sapiens_hsa052230.46079991
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45693042
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44876295
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42363326
124Renal cell carcinoma_Homo sapiens_hsa052110.41613904
125Vibrio cholerae infection_Homo sapiens_hsa051100.41552166
126Butanoate metabolism_Homo sapiens_hsa006500.40893318
127Endocytosis_Homo sapiens_hsa041440.40435779
128Oocyte meiosis_Homo sapiens_hsa041140.39906539
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39043641
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37903270
131Ovarian steroidogenesis_Homo sapiens_hsa049130.35238721
132Insulin signaling pathway_Homo sapiens_hsa049100.35037219
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.34939276
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33369594
135Platelet activation_Homo sapiens_hsa046110.32017669
136Circadian rhythm_Homo sapiens_hsa047100.30794135
137Complement and coagulation cascades_Homo sapiens_hsa046100.30300716
138Chemokine signaling pathway_Homo sapiens_hsa040620.29620299
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28972609
140Endometrial cancer_Homo sapiens_hsa052130.27851003
141Fatty acid biosynthesis_Homo sapiens_hsa000610.27035823
142Glycerolipid metabolism_Homo sapiens_hsa005610.26685528
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25375822

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