DOCK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.97861941
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.11047865
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.11047865
4modulation by symbiont of host immune response (GO:0052553)5.11047865
5positive regulation by symbiont of host defense response (GO:0052509)5.11047865
6modulation by symbiont of host defense response (GO:0052031)5.11047865
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.11047865
8glomerular visceral epithelial cell development (GO:0072015)4.70557280
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.50470291
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46861748
11macrophage activation involved in immune response (GO:0002281)4.45732042
12cellular extravasation (GO:0045123)4.44420569
13microglial cell activation (GO:0001774)4.34001621
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33611254
15negative regulation of cell killing (GO:0031342)4.33611254
16neutrophil activation involved in immune response (GO:0002283)4.30789254
17detection of external biotic stimulus (GO:0098581)4.28936517
18positive regulation of gamma-delta T cell activation (GO:0046645)4.26326600
19cell adhesion mediated by integrin (GO:0033627)4.14300218
20regulation of interferon-beta biosynthetic process (GO:0045357)4.12621997
21glomerular epithelial cell development (GO:0072310)4.10739107
22glomerular basement membrane development (GO:0032836)4.00639185
23regulation of B cell receptor signaling pathway (GO:0050855)3.98841911
24neutrophil mediated immunity (GO:0002446)3.85943662
25macrophage activation (GO:0042116)3.84888770
26response to peptidoglycan (GO:0032494)3.82058041
27negative regulation of interleukin-12 production (GO:0032695)3.79458843
28detection of other organism (GO:0098543)3.69758067
29detection of biotic stimulus (GO:0009595)3.66723777
30positive regulation of p38MAPK cascade (GO:1900745)3.59324067
31regulation of lipoprotein metabolic process (GO:0050746)3.59253103
32apoptotic cell clearance (GO:0043277)3.58871616
33neutrophil activation (GO:0042119)3.58650472
34response to host immune response (GO:0052572)3.55440347
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55440347
36response to host (GO:0075136)3.52845291
37response to host defenses (GO:0052200)3.52845291
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.52845291
39mesodermal cell differentiation (GO:0048333)3.42664605
40negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.35216014
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.30989567
42endodermal cell differentiation (GO:0035987)3.28368629
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.26975513
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.25756582
45protein localization to endosome (GO:0036010)3.24490476
46negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24202172
47negative regulation of T-helper cell differentiation (GO:0045623)3.24202172
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.22719943
49granulocyte activation (GO:0036230)3.17292407
50negative regulation of complement activation (GO:0045916)3.17252179
51antigen processing and presentation of endogenous antigen (GO:0019883)3.16745420
52myeloid cell activation involved in immune response (GO:0002275)3.12491040
53myeloid leukocyte mediated immunity (GO:0002444)3.11297575
54regulation of gamma-delta T cell activation (GO:0046643)3.08796722
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08155334
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.07460476
57low-density lipoprotein particle clearance (GO:0034383)3.06833878
58intestinal cholesterol absorption (GO:0030299)3.05877261
59response to interleukin-15 (GO:0070672)3.04655664
60iron ion import (GO:0097286)3.03090253
61response to interferon-alpha (GO:0035455)3.01660222
62detection of bacterium (GO:0016045)2.98306174
63regulation of interleukin-6 biosynthetic process (GO:0045408)2.97953121
64regulation of macrophage cytokine production (GO:0010935)2.97830839
65leukocyte migration involved in inflammatory response (GO:0002523)2.96963341
66positive regulation of interferon-alpha production (GO:0032727)2.96782339
67dendritic cell migration (GO:0036336)2.96413723
68leukocyte aggregation (GO:0070486)2.95721706
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94510703
70cellular response to ethanol (GO:0071361)2.93427801
71cellular response to interferon-alpha (GO:0035457)2.92132943
72hemidesmosome assembly (GO:0031581)2.91997020
73production of molecular mediator involved in inflammatory response (GO:0002532)2.91660185
74myelin maintenance (GO:0043217)2.91648862
75negative regulation of protein activation cascade (GO:2000258)2.90961538
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89146544
77positive regulation of osteoblast proliferation (GO:0033690)2.88363327
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87946221
79positive regulation of macrophage cytokine production (GO:0060907)2.87938976
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85190431
81positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84695060
82negative regulation of humoral immune response (GO:0002921)2.84034368
83regulation of mast cell degranulation (GO:0043304)2.83569826
84regulation of gamma-delta T cell differentiation (GO:0045586)2.81088020
85skin morphogenesis (GO:0043589)2.80982994
86response to laminar fluid shear stress (GO:0034616)2.79468405
87regulation of mast cell activation involved in immune response (GO:0033006)2.77411640
88substrate adhesion-dependent cell spreading (GO:0034446)2.76684504
89regulation of mast cell activation (GO:0033003)2.76416070
90negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75821592
91regulation of interferon-alpha production (GO:0032647)2.74936313
92negative regulation of T cell mediated immunity (GO:0002710)2.74634371
93import into cell (GO:0098657)2.73465814
94cellular response to interleukin-15 (GO:0071350)2.71804962
95regulation of platelet aggregation (GO:0090330)2.71695951
96angiotensin maturation (GO:0002003)2.70121991
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.70016298
98intestinal absorption (GO:0050892)2.69133626
99cell-substrate junction assembly (GO:0007044)2.68521268
100antigen processing and presentation via MHC class Ib (GO:0002475)2.66813466
101regulation of integrin activation (GO:0033623)2.65174911
102respiratory burst (GO:0045730)2.64270316
103positive regulation of mast cell activation (GO:0033005)2.63825446
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.63632166
105regulation of cholesterol homeostasis (GO:2000188)2.61942626
106B cell receptor signaling pathway (GO:0050853)2.60755367
107positive regulation of interferon-beta production (GO:0032728)2.60570781
108regulation of myeloid leukocyte mediated immunity (GO:0002886)2.59793905
109anterior/posterior axis specification, embryo (GO:0008595)2.59195410
110positive regulation of receptor recycling (GO:0001921)2.58988516
111integrin-mediated signaling pathway (GO:0007229)2.58932797
112regulation of interleukin-8 biosynthetic process (GO:0045414)2.57804886
113negative regulation of leukocyte mediated immunity (GO:0002704)2.57602261
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.55375300
115wound healing, spreading of epidermal cells (GO:0035313)2.55195317
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54760977
117negative regulation of interleukin-1 production (GO:0032692)2.54585324
118I-kappaB phosphorylation (GO:0007252)2.54577821
119positive regulation of natural killer cell differentiation (GO:0032825)2.53228350
120immunoglobulin mediated immune response (GO:0016064)2.53003319
121negative regulation of protein autophosphorylation (GO:0031953)2.52812359
122epithelial cell-cell adhesion (GO:0090136)2.51710889
123pathway-restricted SMAD protein phosphorylation (GO:0060389)2.50606778
124T-helper 1 type immune response (GO:0042088)2.50410080
125regulation of leukocyte degranulation (GO:0043300)2.49663147
126protein-lipid complex assembly (GO:0065005)2.48888130
127regulation of necroptotic process (GO:0060544)2.48607280
128renal filtration (GO:0097205)2.47809177
129negative regulation of fibrinolysis (GO:0051918)2.47663107
130negative regulation of interleukin-6 production (GO:0032715)2.45879267
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.44740439
132phospholipid homeostasis (GO:0055091)2.42933435
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.42697856
134growth hormone receptor signaling pathway (GO:0060396)2.40191151
135central nervous system myelination (GO:0022010)2.40046507
136axon ensheathment in central nervous system (GO:0032291)2.40046507
137wound healing, spreading of cells (GO:0044319)2.39406294
138stress fiber assembly (GO:0043149)2.38087683
139protein carboxylation (GO:0018214)2.37400613
140peptidyl-glutamic acid carboxylation (GO:0017187)2.37400613
141basement membrane organization (GO:0071711)2.35646288
142nuclear pore complex assembly (GO:0051292)2.34238248
143positive regulation of Rho protein signal transduction (GO:0035025)2.31014306
144membrane raft organization (GO:0031579)2.30013200
145lipoprotein metabolic process (GO:0042157)2.29268101
146mannose metabolic process (GO:0006013)2.29053895
147cortical actin cytoskeleton organization (GO:0030866)2.26671269
148epoxygenase P450 pathway (GO:0019373)2.26571518
149plasma lipoprotein particle clearance (GO:0034381)2.23936562
150establishment of endothelial barrier (GO:0061028)2.23899035
151sterol homeostasis (GO:0055092)2.23834714
152cholesterol homeostasis (GO:0042632)2.22198360
153collagen fibril organization (GO:0030199)2.20149308
154alpha-linolenic acid metabolic process (GO:0036109)2.20123972
155very-low-density lipoprotein particle assembly (GO:0034379)2.20010280
156trophectodermal cell differentiation (GO:0001829)2.19724312
157hypotonic response (GO:0006971)2.17968657
158adherens junction assembly (GO:0034333)2.16573110
159viral entry into host cell (GO:0046718)2.16381632
160hepatocyte apoptotic process (GO:0097284)2.16092617
161cytoplasmic mRNA processing body assembly (GO:0033962)2.15819400
162regulation of triglyceride catabolic process (GO:0010896)2.15738866
163plasma lipoprotein particle assembly (GO:0034377)2.15689960
164regulation of apoptotic cell clearance (GO:2000425)2.15368028
165positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.14911000
166defense response to fungus (GO:0050832)2.14603866
167L-phenylalanine catabolic process (GO:0006559)2.14320242
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.14320242
169apoptotic process involved in morphogenesis (GO:0060561)2.13990535
170embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13902855
171regulation of p38MAPK cascade (GO:1900744)2.13857955
172positive regulation of hemostasis (GO:1900048)2.13839386
173positive regulation of blood coagulation (GO:0030194)2.13839386
174membrane protein ectodomain proteolysis (GO:0006509)2.12410980
175nuclear pore organization (GO:0006999)2.12388051
176sequestering of metal ion (GO:0051238)2.12300207
177thrombin receptor signaling pathway (GO:0070493)2.12278677
178positive regulation of cell adhesion mediated by integrin (GO:0033630)2.11964119
179fibrinolysis (GO:0042730)2.10685520
180hippo signaling (GO:0035329)2.10124674
181macroautophagy (GO:0016236)2.09832834
182platelet-derived growth factor receptor signaling pathway (GO:0048008)2.09678011
183positive regulation of endothelial cell apoptotic process (GO:2000353)2.08942584
184cell migration involved in sprouting angiogenesis (GO:0002042)2.07748630
185erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.07050030
186L-phenylalanine metabolic process (GO:0006558)2.07050030
187negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.06913194
188endocardial cushion development (GO:0003197)2.06772701
189heterochromatin organization (GO:0070828)2.06574677
190regulation of complement activation (GO:0030449)2.04475228
191positive regulation of coagulation (GO:0050820)2.04209551
192regulation of hippo signaling (GO:0035330)2.03749633
193regulation of protein activation cascade (GO:2000257)2.03473958
194amyloid precursor protein metabolic process (GO:0042982)2.03370040
195blood vessel endothelial cell migration (GO:0043534)2.03298461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human4.49434704
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.23834254
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.07613559
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.29606078
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.10143320
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92346309
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.51982761
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.47337384
9* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43206948
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.39984565
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.39458265
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.38780977
13CLOCK_20551151_ChIP-Seq_293T_Human2.36729913
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.35764554
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.32090080
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22424113
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.19521142
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.16056070
19RUNX_20019798_ChIP-Seq_JUKART_Human2.15227818
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14311689
21E2F7_22180533_ChIP-Seq_HELA_Human2.10251261
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06204750
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04320920
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.02574794
25AR_21909140_ChIP-Seq_LNCAP_Human2.01998332
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.00774090
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.99219767
28VDR_24787735_ChIP-Seq_THP-1_Human1.97745217
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.96193722
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.95686820
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85636060
32* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.85555744
33TP53_16413492_ChIP-PET_HCT116_Human1.80848091
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78658532
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78551012
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76752588
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75208231
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72730551
39SPI1_23127762_ChIP-Seq_K562_Human1.72412678
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71506438
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70699583
42* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66841932
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66838632
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66838632
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64759972
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64062995
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.62071068
48* SPI1_23547873_ChIP-Seq_NB4_Human1.61652219
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61042091
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60423724
51SCL_19346495_ChIP-Seq_HPC-7_Human1.60407077
52GATA6_25053715_ChIP-Seq_YYC3_Human1.58698974
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56853677
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55216929
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55216929
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55216929
57* GATA4_25053715_ChIP-Seq_YYC3_Human1.54403284
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53942329
59* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52314777
60GATA1_22025678_ChIP-Seq_K562_Human1.51773142
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49720424
62MYB_26560356_Chip-Seq_TH2_Human1.49014934
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46658137
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46136377
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45629299
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45049868
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43528631
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42659176
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.38577700
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37680592
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.35654477
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35569212
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35477271
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34422289
75SOX2_20726797_ChIP-Seq_SW620_Human1.32745752
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32226044
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.31243508
78* IRF8_27001747_Chip-Seq_BMDM_Mouse1.31079998
79FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30943243
80VDR_24763502_ChIP-Seq_THP-1_Human1.30012310
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.29543004
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28842549
83MYB_26560356_Chip-Seq_TH1_Human1.28230286
84* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26086045
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.25134214
86RACK7_27058665_Chip-Seq_MCF-7_Human1.24933748
87* CJUN_26792858_Chip-Seq_BT549_Human1.24143318
88PU_27001747_Chip-Seq_BMDM_Mouse1.23270883
89* ATF3_27146783_Chip-Seq_COLON_Human1.22774435
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22070000
91* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21277392
92* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21010091
93* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21010091
94AHR_22903824_ChIP-Seq_MCF-7_Human1.20858216
95GATA3_26560356_Chip-Seq_TH2_Human1.20719398
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18022570
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17594725
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17036493
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15627477
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15152261
101GATA3_27048872_Chip-Seq_THYMUS_Human1.14840963
102STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14674348
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14657515
104* BRD4_25478319_ChIP-Seq_HGPS_Human1.12715665
105RUNX1_22412390_ChIP-Seq_EML_Mouse1.12233468
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11743565
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11527750
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11403857
109* TP63_23658742_ChIP-Seq_EP156T_Human1.10609113
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10408572
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09970198
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09581871
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08235940
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08126381
115* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08006334
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.07422418
117CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07301409
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06630860
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.06407556
120* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06037452
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05004592
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04436530
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04425944
124TP53_22127205_ChIP-Seq_IMR90_Human1.03781229
125FLI1_27457419_Chip-Seq_LIVER_Mouse1.02297321
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02062252
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.01991629
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01361092
129ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00918955
130FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00652086
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00543340
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00335631
133* KLF5_25053715_ChIP-Seq_YYC3_Human1.00268911
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00041784
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99930008
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99519109
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.98948418
138GATA2_19941826_ChIP-Seq_K562_Human0.97998547
139NCOR1_26117541_ChIP-Seq_K562_Human0.97145240
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96985161
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96340868
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.96239563
143RUNX1_27514584_Chip-Seq_MCF-7_Human0.95780993
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95731781
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95551595
146TCF7_22412390_ChIP-Seq_EML_Mouse0.95147272
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.93466451
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93261431
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91733554
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.89814533
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87278804
152* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85809626
153POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85679130
154ER_23166858_ChIP-Seq_MCF-7_Human0.84496742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.21444183
2MP0003705_abnormal_hypodermis_morpholog3.57648772
3MP0008438_abnormal_cutaneous_collagen3.21140140
4MP0005360_urolithiasis3.17421317
5MP0001835_abnormal_antigen_presentation2.99640603
6MP0010352_gastrointestinal_tract_polyps2.92716175
7MP0003566_abnormal_cell_adhesion2.60045821
8MP0003828_pulmonary_edema2.57387221
9MP0008260_abnormal_autophagy2.50602418
10MP0003950_abnormal_plasma_membrane2.35929370
11MP0005023_abnormal_wound_healing2.26056136
12MP0009840_abnormal_foam_cell2.25763319
13MP0005623_abnormal_meninges_morphology2.22934721
14MP0000685_abnormal_immune_system2.12526307
15MP0003300_gastrointestinal_ulcer2.10930030
16MP0004264_abnormal_extraembryonic_tissu2.09190125
17MP0003806_abnormal_nucleotide_metabolis2.02483573
18MP0002139_abnormal_hepatobiliary_system1.96569065
19MP0004272_abnormal_basement_membrane1.90302812
20MP0009785_altered_susceptibility_to1.88420728
21MP0003172_abnormal_lysosome_physiology1.86991889
22MP0001800_abnormal_humoral_immune1.86686120
23MP0002166_altered_tumor_susceptibility1.80603376
24MP0005025_abnormal_response_to1.79718088
25MP0005000_abnormal_immune_tolerance1.78353231
26MP0002723_abnormal_immune_serum1.75659322
27MP0003091_abnormal_cell_migration1.73802482
28MP0002452_abnormal_antigen_presenting1.72828566
29MP0002396_abnormal_hematopoietic_system1.70825561
30MP0001958_emphysema1.65454970
31MP0003252_abnormal_bile_duct1.64481705
32MP0005451_abnormal_body_composition1.62589466
33MP0002420_abnormal_adaptive_immunity1.60929730
34MP0001819_abnormal_immune_cell1.59509739
35MP0005387_immune_system_phenotype1.59069355
36MP0001790_abnormal_immune_system1.59069355
37MP0002148_abnormal_hypersensitivity_rea1.57215883
38MP0003453_abnormal_keratinocyte_physiol1.56330579
39MP0005058_abnormal_lysosome_morphology1.55828854
40MP0002405_respiratory_system_inflammati1.51834478
41MP0009278_abnormal_bone_marrow1.51230089
42MP0005085_abnormal_gallbladder_physiolo1.47916557
43MP0005076_abnormal_cell_differentiation1.47268122
44MP0005275_abnormal_skin_tensile1.46814334
45MP0000015_abnormal_ear_pigmentation1.45624104
46MP0010307_abnormal_tumor_latency1.44521914
47MP0001666_abnormal_nutrient_absorption1.42431494
48MP0005174_abnormal_tail_pigmentation1.39767646
49MP0004381_abnormal_hair_follicle1.35930666
50MP0006054_spinal_hemorrhage1.35819830
51MP0010234_abnormal_vibrissa_follicle1.32962354
52MP0001845_abnormal_inflammatory_respons1.32634463
53MP0009764_decreased_sensitivity_to1.32580235
54MP0000569_abnormal_digit_pigmentation1.32347477
55MP0001849_ear_inflammation1.32062698
56MP0004484_altered_response_of1.30336374
57MP0010678_abnormal_skin_adnexa1.30250990
58MP0005365_abnormal_bile_salt1.28477883
59MP0002332_abnormal_exercise_endurance1.27912366
60MP0003279_aneurysm1.25279398
61MP0003763_abnormal_thymus_physiology1.24707557
62MP0002006_tumorigenesis1.24313753
63MP0002060_abnormal_skin_morphology1.23858816
64MP0002132_abnormal_respiratory_system1.21543105
65MP0003866_abnormal_defecation1.20451247
66MP0000716_abnormal_immune_system1.18054600
67MP0005408_hypopigmentation1.16940531
68MP0009384_cardiac_valve_regurgitation1.16833219
69MP0002398_abnormal_bone_marrow1.16281059
70MP0003075_altered_response_to1.15372382
71MP0003448_altered_tumor_morphology1.15276761
72MP0002998_abnormal_bone_remodeling1.15112327
73MP0005671_abnormal_response_to1.12802458
74MP0004947_skin_inflammation1.12327033
75MP0005310_abnormal_salivary_gland1.10600427
76MP0003303_peritoneal_inflammation1.10083028
77MP0000733_abnormal_muscle_development1.09471417
78MP0004808_abnormal_hematopoietic_stem1.07990759
79MP0008875_abnormal_xenobiotic_pharmacok1.07476244
80MP0009053_abnormal_anal_canal1.06972142
81MP0001915_intracranial_hemorrhage1.06672936
82MP0003436_decreased_susceptibility_to1.06231363
83MP0008469_abnormal_protein_level1.05929886
84MP0000858_altered_metastatic_potential1.05776761
85MP0003195_calcinosis1.05493321
86MP0000465_gastrointestinal_hemorrhage1.04350511
87MP0005409_darkened_coat_color1.03362039
88MP0005166_decreased_susceptibility_to1.01191666
89MP0010329_abnormal_lipoprotein_level1.00080054
90MP0000427_abnormal_hair_cycle0.98495591
91MP0000689_abnormal_spleen_morphology0.98007306
92MP0002086_abnormal_extraembryonic_tissu0.97685654
93MP0001533_abnormal_skeleton_physiology0.97418735
94MP0000920_abnormal_myelination0.96724735
95MP0000383_abnormal_hair_follicle0.95659732
96MP0001243_abnormal_dermal_layer0.95495028
97MP0002722_abnormal_immune_system0.95339461
98MP0000371_diluted_coat_color0.95098714
99MP0000537_abnormal_urethra_morphology0.94029096
100MP0003045_fibrosis0.92737210
101MP0003191_abnormal_cellular_cholesterol0.91696099
102MP0000604_amyloidosis0.91082306
103MP0003656_abnormal_erythrocyte_physiolo0.90879909
104MP0002429_abnormal_blood_cell0.89209581
105MP0005388_respiratory_system_phenotype0.89030573
106MP0002133_abnormal_respiratory_system0.89030573
107MP0008004_abnormal_stomach_pH0.88907940
108MP0005464_abnormal_platelet_physiology0.88641828
109MP0002697_abnormal_eye_size0.88593351
110MP0002877_abnormal_melanocyte_morpholog0.88496330
111MP0000462_abnormal_digestive_system0.88490146
112MP0000767_abnormal_smooth_muscle0.87290798
113MP0000609_abnormal_liver_physiology0.87210311
114MP0002295_abnormal_pulmonary_circulatio0.85694245
115MP0002419_abnormal_innate_immunity0.85120567
116MP0006082_CNS_inflammation0.84598328
117* MP0005193_abnormal_anterior_eye0.84360911
118MP0003690_abnormal_glial_cell0.83609903
119MP0005376_homeostasis/metabolism_phenot0.83125258
120MP0000249_abnormal_blood_vessel0.83062583
121MP0001614_abnormal_blood_vessel0.83036723
122MP0002925_abnormal_cardiovascular_devel0.81274589
123MP0005508_abnormal_skeleton_morphology0.80203983
124MP0000477_abnormal_intestine_morphology0.79360599
125MP0003183_abnormal_peptide_metabolism0.79166357
126MP0010155_abnormal_intestine_physiology0.78770225
127MP0010368_abnormal_lymphatic_system0.78475493
128MP0004185_abnormal_adipocyte_glucose0.78142974
129MP0000579_abnormal_nail_morphology0.77887233
130MP0005332_abnormal_amino_acid0.77198917
131MP0002092_abnormal_eye_morphology0.76779232
132MP0003984_embryonic_growth_retardation0.76747139
133MP0002168_other_aberrant_phenotype0.76518922
134MP0003115_abnormal_respiratory_system0.76186124
135MP0001672_abnormal_embryogenesis/_devel0.75878642
136MP0005380_embryogenesis_phenotype0.75878642
137MP0004197_abnormal_fetal_growth/weight/0.75081998
138MP0001853_heart_inflammation0.74607512
139MP0005164_abnormal_response_to0.74378637
140MP0009763_increased_sensitivity_to0.74272285
141MP0002088_abnormal_embryonic_growth/wei0.73856513
142MP0008057_abnormal_DNA_replication0.73508425
143MP0001730_embryonic_growth_arrest0.73138624
144MP0002136_abnormal_kidney_physiology0.71332387
145MP0005390_skeleton_phenotype0.71140348
146MP0009643_abnormal_urine_homeostasis0.71120960
147MP0005621_abnormal_cell_physiology0.70387764
148MP0001216_abnormal_epidermal_layer0.69826620
149MP0000490_abnormal_crypts_of0.69747776
150MP0002128_abnormal_blood_circulation0.69480307
151MP0002933_joint_inflammation0.69067260
152MP0000598_abnormal_liver_morphology0.68773490
153MP0004883_abnormal_blood_vessel0.68632467
154MP0002796_impaired_skin_barrier0.68474262
155MP0005397_hematopoietic_system_phenotyp0.68108737
156MP0001545_abnormal_hematopoietic_system0.68108737
157MP0005503_abnormal_tendon_morphology0.67697964
158MP0001851_eye_inflammation0.67260315
159MP0004130_abnormal_muscle_cell0.66805790

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.73981461
2Orchitis (HP:0100796)4.65850905
3Myositis (HP:0100614)4.62842534
4Optic neuritis (HP:0100653)4.38852485
5Retrobulbar optic neuritis (HP:0100654)4.38852485
6Premature rupture of membranes (HP:0001788)3.77423236
7Gingival bleeding (HP:0000225)3.76635615
8Focal segmental glomerulosclerosis (HP:0000097)3.62090711
9Elevated erythrocyte sedimentation rate (HP:0003565)3.55802738
10Abnormality of T cell number (HP:0011839)3.54571830
11T lymphocytopenia (HP:0005403)3.52429711
12Gastrointestinal infarctions (HP:0005244)3.51416264
13Recurrent fungal infections (HP:0002841)3.35178675
14Gingivitis (HP:0000230)3.26027351
15Recurrent skin infections (HP:0001581)3.25929250
16Osteolytic defects of the hand bones (HP:0009699)3.24992812
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.24992812
18Protrusio acetabuli (HP:0003179)3.16724230
19Keratoconjunctivitis sicca (HP:0001097)3.16151712
20Stomatitis (HP:0010280)3.11668741
21Subacute progressive viral hepatitis (HP:0006572)3.10027801
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.08082480
23Recurrent cutaneous fungal infections (HP:0011370)2.98080394
24Chronic mucocutaneous candidiasis (HP:0002728)2.98080394
25Arterial thrombosis (HP:0004420)2.95282036
26Keratoconjunctivitis (HP:0001096)2.89610182
27Deep venous thrombosis (HP:0002625)2.88808571
28Spontaneous hematomas (HP:0007420)2.87918041
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.84929950
30Cervical subluxation (HP:0003308)2.83968889
31Ulnar bowing (HP:0003031)2.82736865
32Shallow orbits (HP:0000586)2.82596631
33Increased mean platelet volume (HP:0011877)2.81369604
34Glomerulosclerosis (HP:0000096)2.80446332
35Aortic dissection (HP:0002647)2.76077261
36Chest pain (HP:0100749)2.74182710
37Intrahepatic cholestasis (HP:0001406)2.71439617
38Episodic fever (HP:0001954)2.71344013
39Prolonged bleeding time (HP:0003010)2.69854724
40Peritonitis (HP:0002586)2.67266104
41Epistaxis (HP:0000421)2.58428666
42Pulmonary infiltrates (HP:0002113)2.56715215
43Mesangial abnormality (HP:0001966)2.56514347
44Atrophic scars (HP:0001075)2.56267678
45Periodontitis (HP:0000704)2.55921737
46Mediastinal lymphadenopathy (HP:0100721)2.55514999
47Xanthomatosis (HP:0000991)2.54335546
48Ankle contracture (HP:0006466)2.53624072
49Abnormal platelet volume (HP:0011876)2.53551914
50Cerebral aneurysm (HP:0004944)2.53089102
51Axonal loss (HP:0003447)2.50408397
52Amyloidosis (HP:0011034)2.48860394
53Aortic aneurysm (HP:0004942)2.47771273
54Hemoptysis (HP:0002105)2.47152738
55Cheilitis (HP:0100825)2.41684028
56Syringomyelia (HP:0003396)2.41258340
57Spinal cord lesions (HP:0100561)2.41258340
58Vasculitis (HP:0002633)2.40534682
59Urticaria (HP:0001025)2.39310813
60Fused cervical vertebrae (HP:0002949)2.38477122
61Myocardial infarction (HP:0001658)2.36300911
62Mitral stenosis (HP:0001718)2.35468093
63Leukocytosis (HP:0001974)2.34100051
64Encephalitis (HP:0002383)2.26317827
65Abnormal albumin level (HP:0012116)2.26001986
66Hypoalbuminemia (HP:0003073)2.26001986
67Vertebral clefting (HP:0008428)2.24778893
68Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23564435
69Pulmonary embolism (HP:0002204)2.20416929
70Flat acetabular roof (HP:0003180)2.17283480
71Obstructive lung disease (HP:0006536)2.16623218
72Chronic obstructive pulmonary disease (HP:0006510)2.16623218
73Short humerus (HP:0005792)2.15993819
74Abnormality of T cells (HP:0002843)2.14033531
75Coronal craniosynostosis (HP:0004440)2.14028259
76Autoimmune thrombocytopenia (HP:0001973)2.13280914
77Abnormal vertebral ossification (HP:0100569)2.12613633
78Meningitis (HP:0001287)2.12198778
79Abnormality of proline metabolism (HP:0010907)2.11893811
80Hydroxyprolinuria (HP:0003080)2.11893811
81Upper limb amyotrophy (HP:0009129)2.10919946
82Distal upper limb amyotrophy (HP:0007149)2.10919946
83Nephritis (HP:0000123)2.10532832
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09995894
85Facial diplegia (HP:0001349)2.08317904
86Pustule (HP:0200039)2.06761226
87Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.06510474
88Persistence of primary teeth (HP:0006335)2.05520908
89Recurrent viral infections (HP:0004429)2.05428012
90Glomerulopathy (HP:0100820)2.04820149
91Eosinophilia (HP:0001880)2.04269584
92Abnormality of the distal phalanx of the thumb (HP:0009617)2.03475696
93Abnormality of the ischium (HP:0003174)2.02230698
94Anorexia (HP:0002039)2.01297687
95Mitral valve prolapse (HP:0001634)2.00752664
96Autoimmune hemolytic anemia (HP:0001890)2.00061284
97Viral hepatitis (HP:0006562)1.99836370
98Wormian bones (HP:0002645)1.96452232
99Osteomyelitis (HP:0002754)1.95875588
100Alopecia of scalp (HP:0002293)1.93739931
101Hypoplastic ischia (HP:0003175)1.92940349
102Cellulitis (HP:0100658)1.92334897
103Hyporeflexia of lower limbs (HP:0002600)1.91911632
104Cardiovascular calcification (HP:0011915)1.91426543
105Granulocytopenia (HP:0001913)1.90208084
106Broad metatarsal (HP:0001783)1.89405227
107Keratitis (HP:0000491)1.88979419
108Abnormal foot bone ossification (HP:0010675)1.88953205
109Gangrene (HP:0100758)1.88771856
110Peripheral demyelination (HP:0011096)1.87609795
111Abnormality of the pericardium (HP:0001697)1.85993979
112Bruising susceptibility (HP:0000978)1.85312414
113Right ventricular cardiomyopathy (HP:0011663)1.85291047
114Bowing of the arm (HP:0006488)1.84443133
115Bowed forearm bones (HP:0003956)1.84443133
116Abnormality of the endocardium (HP:0004306)1.84107011
117Slow saccadic eye movements (HP:0000514)1.83811438
118Abnormality of the common coagulation pathway (HP:0010990)1.82791404
119Acute hepatic failure (HP:0006554)1.82459795
120Hypochromic anemia (HP:0001931)1.82121274
121Thickened calvaria (HP:0002684)1.81841887
122Aneurysm (HP:0002617)1.81713821
123Hypochromic microcytic anemia (HP:0004840)1.80507171
124Radial bowing (HP:0002986)1.79730299
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.79253908
126Abnormality of the frontal sinuses (HP:0002687)1.78779520
127Aplasia/hypoplasia of the humerus (HP:0006507)1.78263569
128Narrow palate (HP:0000189)1.77001052
129Increased IgE level (HP:0003212)1.75343823
130Segmental peripheral demyelination/remyelination (HP:0003481)1.75079564
131Esophageal varix (HP:0002040)1.74976455
132Spastic diplegia (HP:0001264)1.74417205
133Menorrhagia (HP:0000132)1.74251028
134Camptodactyly of toe (HP:0001836)1.74183232
135Spondylolisthesis (HP:0003302)1.73098759
136Arterial tortuosity (HP:0005116)1.73087126
137Disproportionate tall stature (HP:0001519)1.72921746
138Flared iliac wings (HP:0002869)1.72899021
139Short nail (HP:0001799)1.72852473
140Neonatal respiratory distress (HP:0002643)1.72802698
141Vascular tortuosity (HP:0004948)1.72712356
142Ileus (HP:0002595)1.72568511
143Abnormality of the pleura (HP:0002103)1.72492763
144Increased CSF protein (HP:0002922)1.71051418
145Dilatation of the ascending aorta (HP:0005111)1.70762252
146Esophageal atresia (HP:0002032)1.70177004
147Blue sclerae (HP:0000592)1.69938644
148Recurrent bacterial skin infections (HP:0005406)1.69422364
149Vascular calcification (HP:0004934)1.69117798
150Inflammation of the large intestine (HP:0002037)1.69007268
151Hypobetalipoproteinemia (HP:0003563)1.68992312
152Knee flexion contracture (HP:0006380)1.68881543
153Absent frontal sinuses (HP:0002688)1.68626848
154Turricephaly (HP:0000262)1.67961416
155Chronic diarrhea (HP:0002028)1.67898275
156Abnormality of T cell physiology (HP:0011840)1.67814576
157Micronodular cirrhosis (HP:0001413)1.66664720
158Recurrent gram-negative bacterial infections (HP:0005420)1.66176007
159Fat malabsorption (HP:0002630)1.65816856
160Fragile skin (HP:0001030)1.65805847
161Abdominal distention (HP:0003270)1.64952448
162Epidermoid cyst (HP:0200040)1.64529363
163Delayed closure of the anterior fontanelle (HP:0001476)1.64290488
164Metaphyseal cupping (HP:0003021)1.63836781
165Abnormality of macrophages (HP:0004311)1.63398956
166Abnormality of the acetabulum (HP:0003170)1.63347659
167Deviation of the thumb (HP:0009603)1.63259428
168Hand muscle atrophy (HP:0009130)1.61208115
169Stridor (HP:0010307)1.60059349
170Tibial bowing (HP:0002982)1.58315520
171Eczematoid dermatitis (HP:0000976)1.57741304
172Hematochezia (HP:0002573)1.56724821
173Tracheal stenosis (HP:0002777)1.56547266
174Autoamputation (HP:0001218)1.56483165
175Abnormality of the peritoneum (HP:0002585)1.56179524
176Increased density of long bones (HP:0006392)1.55335293
177Abnormal delivery (HP:0001787)1.54908321
178Increased connective tissue (HP:0009025)1.53701778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.37376186
2RIPK43.18173521
3CDK123.06423555
4LATS12.83314521
5BLK2.78195732
6EPHA22.71497985
7TTN2.67260894
8STK102.59127553
9DDR22.53802407
10IRAK42.47802314
11MET2.25976142
12TRPM72.14143715
13ACVR1B2.07725951
14TRIB32.01127569
15TESK21.88195284
16BMPR21.87557380
17STK391.86259207
18MAP3K141.85535614
19BMX1.83973824
20MST41.81731878
21ZAP701.80059159
22PTK61.78670376
23PKN21.76463167
24STK31.75550048
25ERN11.74232882
26LRRK21.68495434
27HCK1.68204726
28JAK31.67641896
29TAOK31.55486649
30GRK61.53808123
31EEF2K1.51993992
32PAK41.50621792
33FRK1.47293860
34IKBKE1.42000676
35FES1.41996765
36PTK21.40495186
37RIPK11.38241135
38CAMK1D1.38216372
39PAK21.32650455
40TXK1.32585639
41PDGFRA1.27502916
42IRAK11.26868347
43MST1R1.26678208
44MAP3K61.24404943
45SIK31.24343359
46MTOR1.23750883
47PRKG21.23407536
48YES11.21704103
49MAP3K81.21460660
50STK381.18613655
51JAK21.16444055
52SYK1.15642194
53CSK1.14741868
54MAP4K11.14420309
55MAP3K121.14085066
56WNK11.13770799
57BTK1.13556821
58TEC1.12817541
59LIMK11.07189296
60CDK61.06373654
61CAMK1G1.02404722
62FGFR21.01452324
63TNK21.00305828
64KSR20.99610320
65PLK40.97926449
66SCYL20.97735409
67DMPK0.97205412
68NEK90.96728252
69SIK10.93633379
70SGK30.92410540
71KIT0.92376748
72KSR10.90946857
73MAP3K10.90125517
74TGFBR20.88082401
75MELK0.87930014
76GSK3A0.87887625
77RAF10.87579573
78FGR0.86429752
79MYLK0.85432692
80ERBB40.84956489
81MAP2K30.84421566
82PDGFRB0.84418448
83LYN0.83985106
84MAP2K20.83755728
85IRAK20.81062094
86LATS20.79874983
87OXSR10.79788968
88NUAK10.79253021
89LCK0.78549156
90TBK10.77811009
91SGK20.77728323
92MARK30.77500200
93NTRK10.76858159
94FGFR10.70833600
95PRKD20.70170171
96IKBKB0.69731591
97ROCK20.68703372
98CAMKK20.68087555
99RPS6KB20.67203125
100PDK10.66857039
101MAPKAPK50.66845022
102NEK20.66285565
103BRD40.64536250
104CDC42BPA0.64130208
105TTK0.64034499
106MAP3K100.63780483
107NLK0.63772811
108JAK10.62242337
109TYK20.61264705
110ADRBK10.60742361
111MARK20.60648569
112WNK40.60437405
113MAP3K30.59702810
114FGFR40.59300533
115STK40.59176892
116FLT30.59061892
117MAP3K50.58930199
118TESK10.58511950
119ALK0.57795611
120STK240.57667992
121CSF1R0.56071066
122MAP3K20.53251314
123PIM10.52320971
124ERBB20.51971542
125PAK30.50855040
126PIK3CA0.50527410
127MAPKAPK20.50381274
128GRK70.50192106
129INSR0.49043893
130FER0.48848667
131MAP3K70.48706569
132MATK0.48556974
133PDPK10.48011069
134MAP3K130.47588199
135PAK10.47451220
136ERBB30.46131743
137EGFR0.46079439
138LMTK20.46066493
139STK110.45378002
140TAOK10.44916196
141EPHB20.43514907
142RET0.42328886
143MAPKAPK30.42071011
144AKT30.40916489
145ABL10.40784950
146ITK0.40453934
147RPS6KA40.40006072
148MAPK10.39008435
149CDK70.38591931
150MAP2K10.38193065
151PRKAA20.38060545
152GRK50.37385133
153PRKD10.37227640
154FGFR30.36169860
155ICK0.35709954
156PIK3CG0.35037344
157PTK2B0.35020915

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.34076939
2Caffeine metabolism_Homo sapiens_hsa002321.97215406
3NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93675036
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91402084
5Tuberculosis_Homo sapiens_hsa051521.90606857
6ECM-receptor interaction_Homo sapiens_hsa045121.88931898
7Renin-angiotensin system_Homo sapiens_hsa046141.80130462
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.75693881
9Complement and coagulation cascades_Homo sapiens_hsa046101.75277824
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71896904
11Steroid biosynthesis_Homo sapiens_hsa001001.70813864
12Histidine metabolism_Homo sapiens_hsa003401.68238301
13Small cell lung cancer_Homo sapiens_hsa052221.63507190
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63130386
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62712403
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.62135402
17B cell receptor signaling pathway_Homo sapiens_hsa046621.57985531
18Staphylococcus aureus infection_Homo sapiens_hsa051501.56799789
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.53892370
20Legionellosis_Homo sapiens_hsa051341.53614540
21Measles_Homo sapiens_hsa051621.49301095
22Adherens junction_Homo sapiens_hsa045201.47567256
23Amoebiasis_Homo sapiens_hsa051461.47511055
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.46912169
25Arginine biosynthesis_Homo sapiens_hsa002201.45812739
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.44722269
27Focal adhesion_Homo sapiens_hsa045101.44399902
28Fat digestion and absorption_Homo sapiens_hsa049751.43907917
29Non-small cell lung cancer_Homo sapiens_hsa052231.39154444
30Vitamin digestion and absorption_Homo sapiens_hsa049771.38064624
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37457367
32Hematopoietic cell lineage_Homo sapiens_hsa046401.37383422
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37199569
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.35458673
35Lysine degradation_Homo sapiens_hsa003101.34940130
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34433272
37Influenza A_Homo sapiens_hsa051641.32177933
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32166614
39Chemokine signaling pathway_Homo sapiens_hsa040621.30030963
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26201761
41Graft-versus-host disease_Homo sapiens_hsa053321.25192737
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24155232
43Proteoglycans in cancer_Homo sapiens_hsa052051.19774968
44African trypanosomiasis_Homo sapiens_hsa051431.18678086
45Hepatitis B_Homo sapiens_hsa051611.17732459
46Acute myeloid leukemia_Homo sapiens_hsa052211.16166380
47T cell receptor signaling pathway_Homo sapiens_hsa046601.15132681
48Bladder cancer_Homo sapiens_hsa052191.12106770
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10941555
50PPAR signaling pathway_Homo sapiens_hsa033201.09344603
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06726957
52Leishmaniasis_Homo sapiens_hsa051401.03949925
53MicroRNAs in cancer_Homo sapiens_hsa052061.02879699
54Glutathione metabolism_Homo sapiens_hsa004801.00786664
55Folate biosynthesis_Homo sapiens_hsa007900.99712040
56Allograft rejection_Homo sapiens_hsa053300.96811171
57TGF-beta signaling pathway_Homo sapiens_hsa043500.96690015
58Tryptophan metabolism_Homo sapiens_hsa003800.96018506
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95664957
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95558880
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94024513
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93112758
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92086780
64One carbon pool by folate_Homo sapiens_hsa006700.91016010
65Pancreatic cancer_Homo sapiens_hsa052120.90909754
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89982206
67Chronic myeloid leukemia_Homo sapiens_hsa052200.89529470
68Bile secretion_Homo sapiens_hsa049760.89461557
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89030193
70FoxO signaling pathway_Homo sapiens_hsa040680.87635662
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87049014
72Protein digestion and absorption_Homo sapiens_hsa049740.86979700
73Prolactin signaling pathway_Homo sapiens_hsa049170.86515867
74Mineral absorption_Homo sapiens_hsa049780.86439215
75Shigellosis_Homo sapiens_hsa051310.85965411
76Vitamin B6 metabolism_Homo sapiens_hsa007500.85637794
77Tight junction_Homo sapiens_hsa045300.85451874
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84935778
79Inositol phosphate metabolism_Homo sapiens_hsa005620.84606795
80Arginine and proline metabolism_Homo sapiens_hsa003300.84283831
81Toxoplasmosis_Homo sapiens_hsa051450.83474619
82Malaria_Homo sapiens_hsa051440.82631259
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82031153
84Herpes simplex infection_Homo sapiens_hsa051680.81480261
85Sulfur metabolism_Homo sapiens_hsa009200.80874165
86Fatty acid degradation_Homo sapiens_hsa000710.78910296
87Hippo signaling pathway_Homo sapiens_hsa043900.78321226
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78319541
89ABC transporters_Homo sapiens_hsa020100.78000508
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.77384718
91Endocytosis_Homo sapiens_hsa041440.77120265
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76341994
93VEGF signaling pathway_Homo sapiens_hsa043700.75311817
94Chemical carcinogenesis_Homo sapiens_hsa052040.74916609
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.74023671
96Endometrial cancer_Homo sapiens_hsa052130.73897463
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.73506602
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73457751
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73099577
100Dorso-ventral axis formation_Homo sapiens_hsa043200.73086936
101Lysosome_Homo sapiens_hsa041420.73067420
102Prostate cancer_Homo sapiens_hsa052150.71037660
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.70993460
104Salmonella infection_Homo sapiens_hsa051320.70820287
105Fatty acid elongation_Homo sapiens_hsa000620.70746697
106Selenocompound metabolism_Homo sapiens_hsa004500.70730345
107Antigen processing and presentation_Homo sapiens_hsa046120.70334738
108Other glycan degradation_Homo sapiens_hsa005110.69753116
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.69493585
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68338154
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67742817
112GnRH signaling pathway_Homo sapiens_hsa049120.67655676
113Retinol metabolism_Homo sapiens_hsa008300.66950045
114mTOR signaling pathway_Homo sapiens_hsa041500.66867482
115Fatty acid metabolism_Homo sapiens_hsa012120.65031873
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64743042
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64738211
118Glioma_Homo sapiens_hsa052140.64686868
119Choline metabolism in cancer_Homo sapiens_hsa052310.64518835
120Renal cell carcinoma_Homo sapiens_hsa052110.64380939
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64214598
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63432816
123Pertussis_Homo sapiens_hsa051330.63168486
124Apoptosis_Homo sapiens_hsa042100.63108323
125Viral myocarditis_Homo sapiens_hsa054160.62386461
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.61657287
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60112321
128TNF signaling pathway_Homo sapiens_hsa046680.59062068
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.58921379
130Platelet activation_Homo sapiens_hsa046110.58113057
131Peroxisome_Homo sapiens_hsa041460.58024166
132Pathways in cancer_Homo sapiens_hsa052000.55291464
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55088692
134ErbB signaling pathway_Homo sapiens_hsa040120.53554877
135Notch signaling pathway_Homo sapiens_hsa043300.53430399
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52313500
137MAPK signaling pathway_Homo sapiens_hsa040100.52025021
138Linoleic acid metabolism_Homo sapiens_hsa005910.52013816
139HIF-1 signaling pathway_Homo sapiens_hsa040660.51420386
140Ether lipid metabolism_Homo sapiens_hsa005650.50401459
141Osteoclast differentiation_Homo sapiens_hsa043800.50100567
142Insulin resistance_Homo sapiens_hsa049310.48602005
143Type I diabetes mellitus_Homo sapiens_hsa049400.48546094
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.46938814
145Arachidonic acid metabolism_Homo sapiens_hsa005900.46325368
146Viral carcinogenesis_Homo sapiens_hsa052030.46130010
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45937708
148Hepatitis C_Homo sapiens_hsa051600.45696157
149Pentose phosphate pathway_Homo sapiens_hsa000300.45232929
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.45132975
151Phagosome_Homo sapiens_hsa041450.45086097
152Rap1 signaling pathway_Homo sapiens_hsa040150.44888322
153Melanoma_Homo sapiens_hsa052180.44622575
154Fatty acid biosynthesis_Homo sapiens_hsa000610.44226609
155Biosynthesis of amino acids_Homo sapiens_hsa012300.43890660
156beta-Alanine metabolism_Homo sapiens_hsa004100.43695116
157Intestinal immune network for IgA production_Homo sapiens_hsa046720.42583120
158Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41384731

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