DOCK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.10147891
2regulation of gene silencing by miRNA (GO:0060964)5.10147891
3regulation of gene silencing by RNA (GO:0060966)5.10147891
4paraxial mesoderm development (GO:0048339)4.90681445
5establishment of apical/basal cell polarity (GO:0035089)4.53252410
6polarized epithelial cell differentiation (GO:0030859)4.28920347
7semaphorin-plexin signaling pathway (GO:0071526)4.18723961
8vascular endothelial growth factor signaling pathway (GO:0038084)4.08623000
9regulation of hippo signaling (GO:0035330)4.00358760
10basement membrane organization (GO:0071711)3.95398362
11positive regulation of SMAD protein import into nucleus (GO:0060391)3.93959052
12desmosome organization (GO:0002934)3.81470150
13pre-miRNA processing (GO:0031054)3.70193258
14anterior/posterior axis specification, embryo (GO:0008595)3.70142536
15establishment of monopolar cell polarity (GO:0061162)3.63878283
16establishment or maintenance of monopolar cell polarity (GO:0061339)3.63878283
17regulation of SMAD protein import into nucleus (GO:0060390)3.60996579
18endothelial cell chemotaxis (GO:0035767)3.59184096
19hemidesmosome assembly (GO:0031581)3.58641499
20cardiac myofibril assembly (GO:0055003)3.56427289
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52192229
22apoptotic process involved in morphogenesis (GO:0060561)3.51920521
23surfactant homeostasis (GO:0043129)3.51174559
24positive regulation of protein kinase C signaling (GO:0090037)3.49163415
25renal filtration (GO:0097205)3.37908499
26glomerular filtration (GO:0003094)3.35811374
27cell migration involved in sprouting angiogenesis (GO:0002042)3.35572425
28heart trabecula formation (GO:0060347)3.32959254
29lymph vessel development (GO:0001945)3.28751064
30nuclear pore organization (GO:0006999)3.27847982
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.27468216
32adherens junction assembly (GO:0034333)3.27064609
33cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.26208383
34regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.25010520
35endothelial tube morphogenesis (GO:0061154)3.24487626
36morphogenesis of an endothelium (GO:0003159)3.24487626
37nuclear pore complex assembly (GO:0051292)3.14588842
38blood vessel endothelial cell migration (GO:0043534)3.12820003
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.12430307
40retina vasculature morphogenesis in camera-type eye (GO:0061299)3.11856327
41embryonic placenta development (GO:0001892)3.11073323
42regulation of translational fidelity (GO:0006450)3.10191344
43notochord development (GO:0030903)3.09265244
44epithelial cell-cell adhesion (GO:0090136)3.08357008
45hippo signaling (GO:0035329)3.07081910
46gap junction assembly (GO:0016264)3.03609477
47cell-substrate adherens junction assembly (GO:0007045)3.01962454
48focal adhesion assembly (GO:0048041)3.01962454
49plasma membrane repair (GO:0001778)3.01258385
50wound healing, spreading of epidermal cells (GO:0035313)3.01236784
51endothelial cell morphogenesis (GO:0001886)2.99552527
52heterochromatin organization (GO:0070828)2.97946079
53negative regulation of fatty acid transport (GO:2000192)2.96341512
54cell proliferation involved in metanephros development (GO:0072203)2.95532002
55insulin-like growth factor receptor signaling pathway (GO:0048009)2.94930618
56ventricular trabecula myocardium morphogenesis (GO:0003222)2.94828181
57lymphangiogenesis (GO:0001946)2.94042335
58regulation of endothelial cell differentiation (GO:0045601)2.93710760
59negative regulation of chondrocyte differentiation (GO:0032331)2.93397527
60sarcomere organization (GO:0045214)2.90682401
61negative regulation of blood vessel endothelial cell migration (GO:0043537)2.89261445
62endothelial cell differentiation (GO:0045446)2.88427311
63negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.86151202
64glomerular basement membrane development (GO:0032836)2.85333662
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84019751
66cardiac muscle cell development (GO:0055013)2.82765528
67carnitine shuttle (GO:0006853)2.80358354
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.80277295
69low-density lipoprotein particle clearance (GO:0034383)2.79976084
70cell-substrate junction assembly (GO:0007044)2.79315023
71myofibril assembly (GO:0030239)2.78797511
72negative regulation of potassium ion transmembrane transport (GO:1901380)2.78711165
73regulation of cardioblast differentiation (GO:0051890)2.78324841
74regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.78113577
75chemical homeostasis within a tissue (GO:0048875)2.75484089
76cardiac cell development (GO:0055006)2.74871531
77patterning of blood vessels (GO:0001569)2.74149755
78cell volume homeostasis (GO:0006884)2.72450816
79trabecula morphogenesis (GO:0061383)2.72090232
80heart trabecula morphogenesis (GO:0061384)2.71866565
81vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.71711521
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71548425
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69894029
84regulation of cholesterol homeostasis (GO:2000188)2.69732905
85vasculogenesis (GO:0001570)2.69637522
86blood vessel maturation (GO:0001955)2.69264495
87planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68756939
88regulation of blood vessel endothelial cell migration (GO:0043535)2.68751552
89negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.68658348
90ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.68170052
91trabecula formation (GO:0060343)2.65947644
92positive regulation of receptor recycling (GO:0001921)2.65193732
93angiogenesis involved in wound healing (GO:0060055)2.64870869
94negative regulation of cartilage development (GO:0061037)2.64255760
95endodermal cell differentiation (GO:0035987)2.63542219
96negative regulation of focal adhesion assembly (GO:0051895)2.63441306
97negative regulation of cell junction assembly (GO:1901889)2.63441306
98negative regulation of adherens junction organization (GO:1903392)2.63441306
99histone H4-K12 acetylation (GO:0043983)2.62692774
100fatty acid transmembrane transport (GO:1902001)2.61260880
101negative regulation of endothelial cell migration (GO:0010596)2.60273198
102apoptotic process involved in development (GO:1902742)2.60247796
103heart morphogenesis (GO:0003007)2.59977103
104trophectodermal cell differentiation (GO:0001829)2.59909298
105regulation of gene silencing (GO:0060968)2.57751581
106negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.57022743
107positive regulation of catenin import into nucleus (GO:0035413)2.57009496
108positive regulation of endothelial cell migration (GO:0010595)2.54984441
109regulation of p38MAPK cascade (GO:1900744)2.53942761
110coronary vasculature morphogenesis (GO:0060977)2.52266924
111cell migration involved in gastrulation (GO:0042074)2.51902192
112regulation of integrin activation (GO:0033623)2.49180139
113venous blood vessel morphogenesis (GO:0048845)2.48645209
114regulation of endothelial cell migration (GO:0010594)2.48391558
115regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46966363
116cell surface receptor signaling pathway involved in heart development (GO:0061311)2.45564038
117regulation of axon extension involved in axon guidance (GO:0048841)2.45440762
118negative regulation of cell size (GO:0045792)2.45149358
119cell migration involved in heart development (GO:0060973)2.45042961
120negative regulation of histone methylation (GO:0031061)2.44859891
121branching involved in salivary gland morphogenesis (GO:0060445)2.44679788
122negative regulation of fatty acid biosynthetic process (GO:0045717)2.43424535
123endothelium development (GO:0003158)2.42672638
124ovulation from ovarian follicle (GO:0001542)2.42569045
125sprouting angiogenesis (GO:0002040)2.42491604
126regulation of vascular permeability (GO:0043114)2.42265007
127regulation of endothelial cell chemotaxis (GO:2001026)2.42174636
128determination of adult lifespan (GO:0008340)2.41885643
129anatomical structure regression (GO:0060033)2.41402805
130cell proliferation involved in kidney development (GO:0072111)2.41263549
131embryonic foregut morphogenesis (GO:0048617)2.38795553
132cardiac muscle tissue morphogenesis (GO:0055008)2.38292920
133atrioventricular valve morphogenesis (GO:0003181)2.38141813
134chondrocyte proliferation (GO:0035988)2.38036251
135regulation of tight junction assembly (GO:2000810)2.37255613
136maternal placenta development (GO:0001893)2.37086609
137cell-cell junction maintenance (GO:0045217)2.37082909
138neuron projection extension involved in neuron projection guidance (GO:1902284)2.36801761
139axon extension involved in axon guidance (GO:0048846)2.36801761
140blood vessel remodeling (GO:0001974)2.36621417
141nephron epithelium development (GO:0072009)2.34437055
142mRNA transcription (GO:0009299)2.34261009
143substrate-dependent cell migration (GO:0006929)2.33386816
144establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.31689741
145substrate adhesion-dependent cell spreading (GO:0034446)2.31657730
146glomerular visceral epithelial cell development (GO:0072015)2.31031410
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30674060
148adherens junction organization (GO:0034332)2.30060342
149establishment of epithelial cell polarity (GO:0090162)2.29615844
150regulation of protein polyubiquitination (GO:1902914)2.29203380
151regulation of glomerular filtration (GO:0003093)2.28735288
152protein heterotrimerization (GO:0070208)2.27248530
153cell junction assembly (GO:0034329)2.27133732
154Notch signaling involved in heart development (GO:0061314)2.25342324
155endothelial cell migration (GO:0043542)2.24789167
156neural tube development (GO:0021915)2.22792526
157response to water (GO:0009415)2.22410792
158ear development (GO:0043583)2.22050317
159negative regulation of catenin import into nucleus (GO:0035414)2.21092591
160heart valve morphogenesis (GO:0003179)2.18838119
161positive regulation of endothelial cell apoptotic process (GO:2000353)2.18272889

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.48198174
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.48198174
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.48198174
4E2F7_22180533_ChIP-Seq_HELA_Human3.48999056
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.37166538
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32531962
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.11694860
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.99301661
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.97117099
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.96498056
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75036856
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.67755737
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.64027221
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.63141191
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.59722440
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53832860
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.50359072
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39543247
19SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.38830197
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.33371937
21ZNF263_19887448_ChIP-Seq_K562_Human2.28066945
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.23920852
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16122069
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.12939777
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.07373949
26CLOCK_20551151_ChIP-Seq_293T_Human2.07217962
27GATA2_21666600_ChIP-Seq_HMVEC_Human2.04874160
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02703009
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96719881
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.88549271
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.85599050
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82763447
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.82285392
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81012478
35NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.78126321
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75497027
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71615930
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.71315775
39POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70831072
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69475737
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69202167
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68307421
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.59333851
44UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58058779
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.57300364
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.55860726
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.51018971
48CTCF_27219007_Chip-Seq_Bcells_Human1.49720410
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49463483
50SOX2_18692474_ChIP-Seq_MEFs_Mouse1.49304578
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47990261
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45763762
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45341856
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43951983
55NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42174282
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.41731564
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.41664623
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41533576
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.41188342
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.41019575
61SMC4_20622854_ChIP-Seq_HELA_Human1.40548255
62SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40364519
63* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39728635
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.39599606
65TP53_22127205_ChIP-Seq_IMR90_Human1.38206376
66P68_20966046_ChIP-Seq_HELA_Human1.37548646
67NANOG_18692474_ChIP-Seq_MESCs_Mouse1.37059625
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36298821
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35330140
70PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.35116748
71RACK7_27058665_Chip-Seq_MCF-7_Human1.34110068
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.32994962
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32952282
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.32319784
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32310635
76TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.31897960
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29668069
78MYC_22102868_ChIP-Seq_BL_Human1.28465196
79NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27527942
80KDM2B_26808549_Chip-Seq_DND41_Human1.26632403
81* DROSHA_22980978_ChIP-Seq_HELA_Human1.26067973
82* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25996381
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.25032322
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.25032322
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23888194
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21747075
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21475779
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21204754
89* TP63_22573176_ChIP-Seq_HFKS_Human1.21199442
90TET1_21490601_ChIP-Seq_MESCs_Mouse1.20450130
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20381745
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20030298
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.19786834
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.19290705
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18946622
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.18825240
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18167263
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18030890
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17981465
100AR_21909140_ChIP-Seq_LNCAP_Human1.17687989
101* TP53_23651856_ChIP-Seq_MEFs_Mouse1.17039120
102CREB1_26743006_Chip-Seq_LNCaP_Human1.16646714
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16183358
104NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15711037
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15681936
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.14558979
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12402030
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12310281
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.11650370
110DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11567377
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10667885
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10061772
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09259822
114ATF3_27146783_Chip-Seq_COLON_Human1.08892938
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08681155
116* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07765778
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05825495
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05147634
119LXR_22292898_ChIP-Seq_THP-1_Human1.04224809
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03315958
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03272437
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03118390
123SA1_27219007_Chip-Seq_ERYTHROID_Human1.03074812
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02955720
125TCF7_22412390_ChIP-Seq_EML_Mouse1.02419147
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01883782
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01336411
128P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01225714
129PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00975056
130SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00389190
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99910871
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.99833855
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99793685
134RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99793685
135POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99753081
136NCOR1_26117541_ChIP-Seq_K562_Human0.99612276
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98941118
138EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98821430
139KDM2B_26808549_Chip-Seq_K562_Human0.98184966
140WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96495005
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94387066
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.93629202
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93511371
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93082131
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93062518
146KLF5_25053715_ChIP-Seq_YYC3_Human0.93009077
147KAP1_27257070_Chip-Seq_ESCs_Mouse0.92305407
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91170422
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89387492
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89365825
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.89272894
152WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88867350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.82745652
2MP0003705_abnormal_hypodermis_morpholog3.57400611
3MP0004272_abnormal_basement_membrane3.29964847
4MP0004084_abnormal_cardiac_muscle3.27280126
5MP0005409_darkened_coat_color3.05409486
6MP0005623_abnormal_meninges_morphology2.43492138
7MP0005167_abnormal_blood-brain_barrier2.23991330
8MP0000013_abnormal_adipose_tissue2.21041117
9MP0001879_abnormal_lymphatic_vessel2.14325863
10MP0000751_myopathy2.09282154
11MP0003566_abnormal_cell_adhesion2.04446909
12MP0005503_abnormal_tendon_morphology2.00692620
13MP0003941_abnormal_skin_development1.88620291
14MP0006138_congestive_heart_failure1.85016929
15MP0002837_dystrophic_cardiac_calcinosis1.84204507
16MP0003567_abnormal_fetal_cardiomyocyte1.83441819
17MP0004036_abnormal_muscle_relaxation1.82812222
18MP0010630_abnormal_cardiac_muscle1.82340284
19MP0005330_cardiomyopathy1.80457308
20MP0003283_abnormal_digestive_organ1.79812060
21MP0010352_gastrointestinal_tract_polyps1.79302013
22MP0003828_pulmonary_edema1.77732067
23MP0005257_abnormal_intraocular_pressure1.74782965
24MP0008438_abnormal_cutaneous_collagen1.69611811
25MP0008775_abnormal_heart_ventricle1.66600092
26MP0000566_synostosis1.65309233
27MP0004133_heterotaxia1.65174267
28MP0004215_abnormal_myocardial_fiber1.64619804
29MP0002127_abnormal_cardiovascular_syste1.64360506
30MP0004782_abnormal_surfactant_physiolog1.62571250
31MP0000750_abnormal_muscle_regeneration1.60044043
32MP0003119_abnormal_digestive_system1.57347516
33MP0002086_abnormal_extraembryonic_tissu1.55654015
34MP0003279_aneurysm1.55455299
35MP0003984_embryonic_growth_retardation1.54860588
36MP0009780_abnormal_chondrocyte_physiolo1.54857879
37MP0002088_abnormal_embryonic_growth/wei1.54046775
38MP0005595_abnormal_vascular_smooth1.53662219
39MP0005380_embryogenesis_phenotype1.53374576
40MP0001672_abnormal_embryogenesis/_devel1.53374576
41MP0010030_abnormal_orbit_morphology1.53118735
42MP0005360_urolithiasis1.51562123
43MP0001958_emphysema1.51268051
44MP0004197_abnormal_fetal_growth/weight/1.50683860
45MP0005076_abnormal_cell_differentiation1.50396845
46MP0003806_abnormal_nucleotide_metabolis1.49062848
47MP0004087_abnormal_muscle_fiber1.47336715
48MP0002925_abnormal_cardiovascular_devel1.45620913
49MP0000678_abnormal_parathyroid_gland1.45209190
50MP0001544_abnormal_cardiovascular_syste1.42433920
51MP0005385_cardiovascular_system_phenoty1.42433920
52MP0004858_abnormal_nervous_system1.41540647
53MP0002084_abnormal_developmental_patter1.40243242
54MP0003091_abnormal_cell_migration1.38704963
55MP0002653_abnormal_ependyma_morphology1.37317664
56MP0005275_abnormal_skin_tensile1.36354333
57MP0001730_embryonic_growth_arrest1.36233881
58MP0005670_abnormal_white_adipose1.36015260
59MP0002085_abnormal_embryonic_tissue1.35818979
60MP0000767_abnormal_smooth_muscle1.34239968
61MP0009278_abnormal_bone_marrow1.33796465
62MP0004185_abnormal_adipocyte_glucose1.33625696
63MP0004264_abnormal_extraembryonic_tissu1.33528050
64MP0000467_abnormal_esophagus_morphology1.33280599
65MP0002933_joint_inflammation1.28628183
66MP0002269_muscular_atrophy1.28443196
67MP0009384_cardiac_valve_regurgitation1.28334048
68MP0002060_abnormal_skin_morphology1.27500258
69MP0000266_abnormal_heart_morphology1.25908098
70MP0008057_abnormal_DNA_replication1.24147564
71MP0000537_abnormal_urethra_morphology1.20366733
72MP0010234_abnormal_vibrissa_follicle1.20251625
73MP0004233_abnormal_muscle_weight1.19585423
74MP0001697_abnormal_embryo_size1.19256660
75MP0005666_abnormal_adipose_tissue1.19179862
76MP0005501_abnormal_skin_physiology1.16691649
77MP0009053_abnormal_anal_canal1.15534128
78MP0000733_abnormal_muscle_development1.14262284
79MP0004957_abnormal_blastocyst_morpholog1.13940652
80MP0001849_ear_inflammation1.12863727
81MP0002128_abnormal_blood_circulation1.10856349
82MP0005023_abnormal_wound_healing1.10677657
83MP0000749_muscle_degeneration1.07132664
84MP0002972_abnormal_cardiac_muscle1.07125341
85MP0002106_abnormal_muscle_physiology1.05390630
86MP0001614_abnormal_blood_vessel1.05182022
87MP0003935_abnormal_craniofacial_develop1.05061226
88MP0002249_abnormal_larynx_morphology1.04475275
89MP0002138_abnormal_hepatobiliary_system1.03640706
90MP0002295_abnormal_pulmonary_circulatio1.03597483
91MP0005367_renal/urinary_system_phenotyp1.03552426
92MP0000516_abnormal_urinary_system1.03552426
93MP0005508_abnormal_skeleton_morphology1.03529625
94MP0003115_abnormal_respiratory_system1.03264927
95MP0002332_abnormal_exercise_endurance1.02698168
96MP0001915_intracranial_hemorrhage1.01412906
97MP0002108_abnormal_muscle_morphology1.01147611
98MP0000579_abnormal_nail_morphology1.00405648
99MP0001293_anophthalmia0.98533572
100MP0003453_abnormal_keratinocyte_physiol0.98430372
101MP0003385_abnormal_body_wall0.98028582
102MP0003137_abnormal_impulse_conducting0.97740405
103MP0005375_adipose_tissue_phenotype0.97139699
104MP0003950_abnormal_plasma_membrane0.96779056
105MP0002080_prenatal_lethality0.96406158
106MP0003111_abnormal_nucleus_morphology0.95450683
107MP0000762_abnormal_tongue_morphology0.94980794
108MP0002089_abnormal_postnatal_growth/wei0.94038498
109MP0005620_abnormal_muscle_contractility0.93458257
110MP0000249_abnormal_blood_vessel0.93176728
111MP0002796_impaired_skin_barrier0.93041027
112MP0002254_reproductive_system_inflammat0.92775771
113MP0002697_abnormal_eye_size0.92453064
114MP0000350_abnormal_cell_proliferation0.91927074
115MP0005369_muscle_phenotype0.90683147
116MP0001661_extended_life_span0.89241163
117MP0003646_muscle_fatigue0.89209035
118MP0004130_abnormal_muscle_cell0.87201523
119MP0000003_abnormal_adipose_tissue0.86152704
120MP0001784_abnormal_fluid_regulation0.86102426
121MP0003123_paternal_imprinting0.85964580
122MP0003077_abnormal_cell_cycle0.84951713
123MP0003122_maternal_imprinting0.84896584
124MP0002896_abnormal_bone_mineralization0.84895880
125MP0009840_abnormal_foam_cell0.83556810
126MP0000534_abnormal_ureter_morphology0.82524909
127MP0004145_abnormal_muscle_electrophysio0.82451083
128MP0000759_abnormal_skeletal_muscle0.82165036
129MP0003890_abnormal_embryonic-extraembry0.81456136
130MP0004085_abnormal_heartbeat0.80868037
131MP0002932_abnormal_joint_morphology0.80783858
132MP0002098_abnormal_vibrissa_morphology0.80033554
133MP0002877_abnormal_melanocyte_morpholog0.78916877
134MP0009115_abnormal_fat_cell0.73953998
135MP0000462_abnormal_digestive_system0.71255875
136MP0002971_abnormal_brown_adipose0.70344929
137MP0005165_increased_susceptibility_to0.70311175
138MP0005451_abnormal_body_composition0.70171092
139MP0002970_abnormal_white_adipose0.70017171
140MP0003942_abnormal_urinary_system0.67241196
141MP0001299_abnormal_eye_distance/0.65955658

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)4.06074099
2Ventricular tachycardia (HP:0004756)3.59849521
3Ependymoma (HP:0002888)3.53496650
4Cerebral aneurysm (HP:0004944)3.38068693
5Sudden death (HP:0001699)3.37257657
6Cervical subluxation (HP:0003308)3.34227382
7Muscle fiber splitting (HP:0003555)3.24286561
8Broad metatarsal (HP:0001783)3.19886753
9Right ventricular cardiomyopathy (HP:0011663)3.19783732
10Hemorrhage of the eye (HP:0011885)3.19486811
11Ankle contracture (HP:0006466)3.19435927
12Hyporeflexia of lower limbs (HP:0002600)3.01293756
13Hypoplastic ischia (HP:0003175)3.00850411
14Bronchomalacia (HP:0002780)2.94588794
15Lymphangioma (HP:0100764)2.91428074
16Nonimmune hydrops fetalis (HP:0001790)2.90769330
17Protrusio acetabuli (HP:0003179)2.90463563
18Neoplasm of the oral cavity (HP:0100649)2.89019303
19Broad face (HP:0000283)2.75352294
20Aortic aneurysm (HP:0004942)2.69752457
21Difficulty running (HP:0009046)2.68845011
22Abnormality of the ischium (HP:0003174)2.66547625
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64855408
24Short 4th metacarpal (HP:0010044)2.64855408
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.61922932
26Pseudobulbar signs (HP:0002200)2.61683007
27Arterial tortuosity (HP:0005116)2.60803212
28Atrophic scars (HP:0001075)2.60126115
29Vascular tortuosity (HP:0004948)2.58072720
30Obstructive sleep apnea (HP:0002870)2.56968781
31Shallow orbits (HP:0000586)2.55639413
32Abnormality of the 4th metacarpal (HP:0010012)2.53205586
33Deep venous thrombosis (HP:0002625)2.52287094
34Polycythemia (HP:0001901)2.50752514
35Astrocytoma (HP:0009592)2.50573443
36Abnormality of the astrocytes (HP:0100707)2.50573443
37Fragile skin (HP:0001030)2.48338554
38Rib fusion (HP:0000902)2.48226161
39Shawl scrotum (HP:0000049)2.47650889
40Aortic dissection (HP:0002647)2.44004525
41Hemangiomatosis (HP:0007461)2.43917628
42Neonatal death (HP:0003811)2.43521882
43Distal lower limb amyotrophy (HP:0008944)2.41693426
44Abnormality of the salivary glands (HP:0010286)2.40352524
45Supernumerary ribs (HP:0005815)2.34718285
46Short humerus (HP:0005792)2.34371805
47Aneurysm (HP:0002617)2.31889998
48J-shaped sella turcica (HP:0002680)2.31159653
49Flat acetabular roof (HP:0003180)2.30352988
50Advanced eruption of teeth (HP:0006288)2.28073264
51Difficulty climbing stairs (HP:0003551)2.27770839
52Exercise-induced muscle cramps (HP:0003710)2.27561896
53Selective tooth agenesis (HP:0001592)2.26991392
54Lipoatrophy (HP:0100578)2.22294281
55Natal tooth (HP:0000695)2.22119984
56Atrial fibrillation (HP:0005110)2.20230557
57Thin bony cortex (HP:0002753)2.20160648
58Aplasia/hypoplasia of the humerus (HP:0006507)2.20065702
59Hip contracture (HP:0003273)2.18555206
60Disproportionate tall stature (HP:0001519)2.16077332
61Blue sclerae (HP:0000592)2.15926834
62Metaphyseal cupping (HP:0003021)2.15921528
63Wormian bones (HP:0002645)2.15795798
64Overgrowth (HP:0001548)2.13558866
65Round ear (HP:0100830)2.11072118
66Abnormality of the lower motor neuron (HP:0002366)2.09739807
67Acanthosis nigricans (HP:0000956)2.09602885
68Supraventricular arrhythmia (HP:0005115)2.08841710
69Type 1 muscle fiber predominance (HP:0003803)2.08709547
70Mesangial abnormality (HP:0001966)2.07541969
71Ectopia lentis (HP:0001083)2.05833893
72Supernumerary bones of the axial skeleton (HP:0009144)2.05751192
73Stridor (HP:0010307)2.05590738
74Ulnar bowing (HP:0003031)2.04322499
75Vertebral clefting (HP:0008428)2.04062545
76Primary atrial arrhythmia (HP:0001692)2.01996249
77Coxa vara (HP:0002812)2.01841232
78Bladder diverticulum (HP:0000015)2.00410819
79Renal duplication (HP:0000075)1.99879430
80Hematochezia (HP:0002573)1.98816686
81Mildly elevated creatine phosphokinase (HP:0008180)1.98529685
82Subaortic stenosis (HP:0001682)1.98404169
83Abnormality of the left ventricular outflow tract (HP:0011103)1.98404169
84Glioma (HP:0009733)1.97394142
85Esophageal atresia (HP:0002032)1.97377789
86Neoplasm of striated muscle (HP:0009728)1.95787784
87Spinal rigidity (HP:0003306)1.94835928
88Missing ribs (HP:0000921)1.94588084
89Increased variability in muscle fiber diameter (HP:0003557)1.92680628
90Venous insufficiency (HP:0005293)1.92583649
91Venous abnormality (HP:0002624)1.92376367
92Stroke (HP:0001297)1.92159255
93Atrioventricular block (HP:0001678)1.91936399
94Supraventricular tachycardia (HP:0004755)1.91281032
95Wrist flexion contracture (HP:0001239)1.91257279
96* Skull defect (HP:0001362)1.91203520
97Rectal prolapse (HP:0002035)1.90325660
98Joint laxity (HP:0001388)1.90289038
99Abnormality of the acetabulum (HP:0003170)1.89689712
100Myoglobinuria (HP:0002913)1.88228014
101Medulloblastoma (HP:0002885)1.86375326
102Soft skin (HP:0000977)1.85242461
103Vertebral fusion (HP:0002948)1.84967991
104EMG: neuropathic changes (HP:0003445)1.84104896
105Asymmetry of the thorax (HP:0001555)1.83558221
106Aortic valve stenosis (HP:0001650)1.83381493
107Skin nodule (HP:0200036)1.83292799
108Trismus (HP:0000211)1.82220921
109Laryngomalacia (HP:0001601)1.81013387
110Intestinal fistula (HP:0100819)1.79865395
111Distal lower limb muscle weakness (HP:0009053)1.79417468
112Fibroma (HP:0010614)1.79198743
113Abnormal vertebral ossification (HP:0100569)1.79088615
114Preaxial foot polydactyly (HP:0001841)1.78898359
115Short phalanx of the thumb (HP:0009660)1.78485085
116Joint stiffness (HP:0001387)1.78375846
117Neonatal short-limb short stature (HP:0008921)1.75509893
118Intestinal polyp (HP:0005266)1.74921327
119Limited hip movement (HP:0008800)1.73681089
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.72421499
121Biconcave vertebral bodies (HP:0004586)1.72260035
122Premature rupture of membranes (HP:0001788)1.72198210
123Rectal fistula (HP:0100590)1.72083003
124Rectovaginal fistula (HP:0000143)1.72083003
125High pitched voice (HP:0001620)1.70803723
126Mitral valve prolapse (HP:0001634)1.70308637
127* Esophageal varix (HP:0002040)1.70296110
128Spastic diplegia (HP:0001264)1.70270082
129Complement deficiency (HP:0004431)1.70262263
130Nuclear cataract (HP:0100018)1.69175879
131Premature skin wrinkling (HP:0100678)1.68880370
132Abnormality of the pubic bones (HP:0003172)1.67918312
133Depressed nasal tip (HP:0000437)1.67824554
134Abnormality of complement system (HP:0005339)1.67759661
135Asymmetric septal hypertrophy (HP:0001670)1.67675037
136Visceral angiomatosis (HP:0100761)1.67460021
137Mitral regurgitation (HP:0001653)1.67201271
138Dilated cardiomyopathy (HP:0001644)1.66488504
139Distal upper limb amyotrophy (HP:0007149)1.66191628
140Upper limb amyotrophy (HP:0009129)1.66191628
141Fibrous tissue neoplasm (HP:0012316)1.66111521
142Abnormal number of incisors (HP:0011064)1.66030826
143Abnormality of dentin (HP:0010299)1.65652557
144Vertebral compression fractures (HP:0002953)1.65264800
145Lumbar hyperlordosis (HP:0002938)1.64959922
146Joint hemorrhage (HP:0005261)1.64876312
147Hyperacusis (HP:0010780)1.64653598
148Pterygium (HP:0001059)1.64389408
149Intestinal polyposis (HP:0200008)1.64104547
150Thin ribs (HP:0000883)1.64034002
151Abnormality of skeletal muscle fiber size (HP:0012084)1.63951284
152Abnormality of the calf musculature (HP:0001430)1.63295211
153Abnormality of the labia minora (HP:0012880)1.62619296
154Short nail (HP:0001799)1.62388877
155Biliary tract neoplasm (HP:0100574)1.62350924
156Wide anterior fontanel (HP:0000260)1.62272453
157Urethral obstruction (HP:0000796)1.62005500
158Rhabdomyolysis (HP:0003201)1.61875048
159Supernumerary spleens (HP:0009799)1.61164417
160Neoplasm of the heart (HP:0100544)1.60784798
161Gastrointestinal carcinoma (HP:0002672)1.60496807
162Malignant gastrointestinal tract tumors (HP:0006749)1.60496807
163Long eyelashes (HP:0000527)1.59985391
164Alopecia of scalp (HP:0002293)1.59751771
165Hypercholesterolemia (HP:0003124)1.57194503
166Aortic regurgitation (HP:0001659)1.55731264
167Aplasia involving bones of the extremities (HP:0009825)1.54955376
168Aplasia of the phalanges of the hand (HP:0009802)1.54955376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.62534446
2CDK124.40454757
3EPHA22.83625925
4KDR2.77496685
5PKN22.72188060
6MST1R2.61089711
7TTN2.58714048
8ICK2.45846150
9RIPK12.16823713
10PDGFRA2.13438056
11LATS12.13192445
12TGFBR21.93754028
13TRIB31.87365239
14NTRK11.83832723
15SMG11.82931000
16NEK11.82674206
17TYRO31.67692094
18LATS21.61849254
19BRD41.61024453
20TGFBR11.59944210
21MAP3K101.59019949
22TTK1.45458167
23MTOR1.43259932
24PAK41.41465536
25MET1.41054097
26MAP3K61.40061176
27EPHB21.31379080
28NEK21.31214833
29ERN11.30453532
30RPS6KB21.29080759
31CAMK1D1.27923526
32PTK61.25092520
33DDR21.24006684
34AKT31.23342609
35CDK71.21168687
36DMPK1.20209152
37FLT31.19017972
38RPS6KA21.16900062
39EEF2K1.10442164
40BMX1.09576620
41MYLK1.02852852
42SIK11.02097773
43PAK21.01398021
44PDK21.00985205
45BCKDK0.99673384
46MARK20.99526374
47PTK20.98054375
48CAMK1G0.95794908
49STK38L0.95736548
50PDK30.93248441
51PDK40.93248441
52WEE10.91483598
53FGFR40.90096452
54CDC70.90068169
55NME10.88066145
56CDK40.87574104
57MUSK0.86906909
58TRPM70.86426455
59IRAK30.84414271
60FER0.83503430
61LMTK20.79512779
62STK40.75446572
63PNCK0.74112376
64STK100.73619316
65STK30.72927201
66PTK2B0.72303579
67FGFR10.71930184
68CDK60.70427976
69PDPK10.70335039
70TESK10.70191073
71FGFR30.67612360
72PDGFRB0.67103202
73FGFR20.66790746
74CDC42BPA0.66183944
75OBSCN0.66183273
76TSSK60.65962279
77MAPK150.64905791
78MAPKAPK30.64586443
79AKT20.64325386
80MAP3K80.63969987
81EPHB10.63770751
82PRKD30.63077162
83PRKG20.61063373
84RPS6KL10.60832689
85RPS6KC10.60832689
86ALK0.60117421
87PRKD10.59144286
88WNK40.58821759
89RET0.58651407
90MAP2K30.58007334
91GSK3A0.55609455
92MAPK120.55326884
93ERBB20.54850279
94PHKG10.54610237
95PHKG20.54610237
96PRKAA20.53080032
97CHEK10.53065582
98PLK10.52469789
99CHEK20.52111475
100ILK0.51917905
101PRKCI0.51158412
102RPS6KA60.50703685
103CSK0.50637083
104CAMK40.48409251
105LRRK20.47838088
106MAP3K30.47693924
107PRKAA10.42405840
108CSNK1D0.42398689
109MAP2K60.42005666
110MAPK70.41770770
111ATM0.41716997
112MAP3K70.40949983
113AURKB0.40656356
114CDK20.40439683
115MAP2K20.39852373
116ROCK10.39737788
117MAPK10.39542040
118PRKD20.38800620
119STK380.37886882
120PIK3CA0.37877943
121CDK90.37109007
122MAP3K130.36969565
123SRC0.36920613
124PAK30.36715679
125CHUK0.36501954
126GRK10.36229017
127PASK0.33896725
128MAP2K10.31939733
129ROCK20.30940223
130HIPK20.30705644
131CDK80.26938231
132EPHA30.25351249
133MAPK110.24537165
134DAPK30.23338730
135MAP3K10.23039457
136ERBB40.22949022
137MAPKAPK20.22487305

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25746286
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54257127
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.46069157
4Notch signaling pathway_Homo sapiens_hsa043302.22918590
5Lysine degradation_Homo sapiens_hsa003102.20102176
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.17259011
7ECM-receptor interaction_Homo sapiens_hsa045122.16412210
8Adherens junction_Homo sapiens_hsa045202.09913353
9Basal cell carcinoma_Homo sapiens_hsa052172.00890279
10Arginine biosynthesis_Homo sapiens_hsa002201.97598543
11Fatty acid degradation_Homo sapiens_hsa000711.85930925
12Nitrogen metabolism_Homo sapiens_hsa009101.77850976
13Focal adhesion_Homo sapiens_hsa045101.73875173
14Biosynthesis of amino acids_Homo sapiens_hsa012301.70136428
15Dilated cardiomyopathy_Homo sapiens_hsa054141.68421818
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65875240
17Carbon metabolism_Homo sapiens_hsa012001.65761930
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64424371
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.60511510
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59622898
21Hippo signaling pathway_Homo sapiens_hsa043901.56354341
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54685296
23Propanoate metabolism_Homo sapiens_hsa006401.52219196
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50615123
25Tight junction_Homo sapiens_hsa045301.48839153
26Hedgehog signaling pathway_Homo sapiens_hsa043401.48541820
27Other glycan degradation_Homo sapiens_hsa005111.47986369
28Fatty acid metabolism_Homo sapiens_hsa012121.47214182
29PPAR signaling pathway_Homo sapiens_hsa033201.39169496
30Small cell lung cancer_Homo sapiens_hsa052221.37346297
31One carbon pool by folate_Homo sapiens_hsa006701.35929307
32Tryptophan metabolism_Homo sapiens_hsa003801.35892604
33Dorso-ventral axis formation_Homo sapiens_hsa043201.31421803
34MicroRNAs in cancer_Homo sapiens_hsa052061.29082807
35Protein digestion and absorption_Homo sapiens_hsa049741.22557655
36Axon guidance_Homo sapiens_hsa043601.21170620
37Histidine metabolism_Homo sapiens_hsa003401.19621386
38Mismatch repair_Homo sapiens_hsa034301.19362236
39Proteoglycans in cancer_Homo sapiens_hsa052051.18721810
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.16998794
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.14628580
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14241038
43RNA transport_Homo sapiens_hsa030131.14217791
44Bile secretion_Homo sapiens_hsa049761.14147028
45Sulfur relay system_Homo sapiens_hsa041221.14074362
46TGF-beta signaling pathway_Homo sapiens_hsa043501.13278113
47Selenocompound metabolism_Homo sapiens_hsa004501.11525623
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.10249713
49Insulin resistance_Homo sapiens_hsa049311.08463218
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08105956
51Pyruvate metabolism_Homo sapiens_hsa006201.05607178
52Viral myocarditis_Homo sapiens_hsa054161.04507301
53ABC transporters_Homo sapiens_hsa020101.04411962
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99812208
55Fatty acid biosynthesis_Homo sapiens_hsa000610.98626691
56mTOR signaling pathway_Homo sapiens_hsa041500.96962144
57Arginine and proline metabolism_Homo sapiens_hsa003300.96133440
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93798422
59Vitamin digestion and absorption_Homo sapiens_hsa049770.92567229
60mRNA surveillance pathway_Homo sapiens_hsa030150.91966304
61AMPK signaling pathway_Homo sapiens_hsa041520.91708342
62Glycerolipid metabolism_Homo sapiens_hsa005610.91497655
63Fat digestion and absorption_Homo sapiens_hsa049750.91496086
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90645782
65Chronic myeloid leukemia_Homo sapiens_hsa052200.89992952
66PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89898374
67GnRH signaling pathway_Homo sapiens_hsa049120.89095048
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88050411
69Bladder cancer_Homo sapiens_hsa052190.86542950
70Pathways in cancer_Homo sapiens_hsa052000.86290087
71Amoebiasis_Homo sapiens_hsa051460.86144562
72Choline metabolism in cancer_Homo sapiens_hsa052310.85819021
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85731074
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84149925
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.83480695
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83235595
77Tyrosine metabolism_Homo sapiens_hsa003500.82367135
78Complement and coagulation cascades_Homo sapiens_hsa046100.81774103
79HIF-1 signaling pathway_Homo sapiens_hsa040660.81309081
80Fructose and mannose metabolism_Homo sapiens_hsa000510.79200701
81Estrogen signaling pathway_Homo sapiens_hsa049150.78358593
82Spliceosome_Homo sapiens_hsa030400.78330059
83Cell cycle_Homo sapiens_hsa041100.76240717
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73622487
85Glucagon signaling pathway_Homo sapiens_hsa049220.73511771
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.72456411
87DNA replication_Homo sapiens_hsa030300.71386208
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.71344736
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70834988
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70269846
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69618720
92Melanogenesis_Homo sapiens_hsa049160.69501821
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69428410
94Rap1 signaling pathway_Homo sapiens_hsa040150.68930924
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68849099
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67385726
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.65413121
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.65314786
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64734788
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.64715528
101Glioma_Homo sapiens_hsa052140.63538755
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61182062
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60621888
104Phenylalanine metabolism_Homo sapiens_hsa003600.57991974
105Insulin signaling pathway_Homo sapiens_hsa049100.56353912
106HTLV-I infection_Homo sapiens_hsa051660.56180583
107Wnt signaling pathway_Homo sapiens_hsa043100.56145058
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55995285
109ErbB signaling pathway_Homo sapiens_hsa040120.55870675
110Caffeine metabolism_Homo sapiens_hsa002320.55633878
111Pentose phosphate pathway_Homo sapiens_hsa000300.54653660
112Galactose metabolism_Homo sapiens_hsa000520.54653519
113Ras signaling pathway_Homo sapiens_hsa040140.54004510
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53896523
115Platelet activation_Homo sapiens_hsa046110.52168968
116Renin-angiotensin system_Homo sapiens_hsa046140.52018582
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50551508
118Starch and sucrose metabolism_Homo sapiens_hsa005000.49504287
119Butanoate metabolism_Homo sapiens_hsa006500.49122712
120Renal cell carcinoma_Homo sapiens_hsa052110.48148784
121Cardiac muscle contraction_Homo sapiens_hsa042600.48104617
122Acute myeloid leukemia_Homo sapiens_hsa052210.47764589
123p53 signaling pathway_Homo sapiens_hsa041150.47620231
124Inositol phosphate metabolism_Homo sapiens_hsa005620.47441770
125Thyroid cancer_Homo sapiens_hsa052160.47420219
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47070870
127beta-Alanine metabolism_Homo sapiens_hsa004100.45789349
128Gap junction_Homo sapiens_hsa045400.45388196
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45157019
130Endometrial cancer_Homo sapiens_hsa052130.44025766
131Base excision repair_Homo sapiens_hsa034100.43328878
132VEGF signaling pathway_Homo sapiens_hsa043700.41123146
133Prostate cancer_Homo sapiens_hsa052150.40306957
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39853969
135Prion diseases_Homo sapiens_hsa050200.39564751
136Ovarian steroidogenesis_Homo sapiens_hsa049130.37017532
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35974766

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