DOCK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.15068472
2planar cell polarity pathway involved in neural tube closure (GO:0090179)3.91495223
3hippo signaling (GO:0035329)3.87533011
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.82345420
5axon extension involved in axon guidance (GO:0048846)3.70012700
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.70012700
7mitotic sister chromatid cohesion (GO:0007064)3.57004990
8chondrocyte proliferation (GO:0035988)3.51567494
9behavioral response to nicotine (GO:0035095)3.48523296
10G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.41623411
11presynaptic membrane assembly (GO:0097105)3.40065024
12metanephric mesenchyme development (GO:0072075)3.38483246
13limb bud formation (GO:0060174)3.31399862
14gastrulation with mouth forming second (GO:0001702)3.23046021
15establishment of nucleus localization (GO:0040023)3.15260241
16regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.12575266
17dorsal/ventral axis specification (GO:0009950)3.12519008
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10797636
19kidney mesenchyme development (GO:0072074)3.09841872
20presynaptic membrane organization (GO:0097090)3.03346582
21collagen fibril organization (GO:0030199)2.99151432
22insulin-like growth factor receptor signaling pathway (GO:0048009)2.95532312
23negative regulation of chondrocyte differentiation (GO:0032331)2.94852676
24appendage development (GO:0048736)2.94178475
25limb development (GO:0060173)2.94178475
26lateral sprouting from an epithelium (GO:0060601)2.92777913
27postsynaptic membrane organization (GO:0001941)2.92080015
28retinal ganglion cell axon guidance (GO:0031290)2.89140755
29embryonic foregut morphogenesis (GO:0048617)2.85351186
30ganglion development (GO:0061548)2.84967173
31outer ear morphogenesis (GO:0042473)2.83972658
32mesenchymal-epithelial cell signaling (GO:0060638)2.81848634
33glial cell proliferation (GO:0014009)2.81266620
34negative regulation of catenin import into nucleus (GO:0035414)2.79449003
35Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.78111217
36sequestering of extracellular ligand from receptor (GO:0035581)2.77991756
37regulation of establishment of planar polarity (GO:0090175)2.77471511
38negative regulation of axon extension involved in axon guidance (GO:0048843)2.75739159
39glucocorticoid receptor signaling pathway (GO:0042921)2.74694505
40central nervous system neuron axonogenesis (GO:0021955)2.74609407
41pyrimidine nucleobase catabolic process (GO:0006208)2.73581187
42cytoplasmic mRNA processing body assembly (GO:0033962)2.73422227
43convergent extension (GO:0060026)2.73403626
44cochlea morphogenesis (GO:0090103)2.70037378
45notochord development (GO:0030903)2.68694468
46negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68073743
47negative regulation of translation, ncRNA-mediated (GO:0040033)2.68073743
48regulation of translation, ncRNA-mediated (GO:0045974)2.68073743
49nonmotile primary cilium assembly (GO:0035058)2.66494747
50bone trabecula formation (GO:0060346)2.65440600
51nuclear pore complex assembly (GO:0051292)2.65128586
52neuronal stem cell maintenance (GO:0097150)2.65075548
53spinal cord development (GO:0021510)2.63760425
54pre-miRNA processing (GO:0031054)2.63190083
55neuron recognition (GO:0008038)2.63062619
56atrial septum morphogenesis (GO:0060413)2.62647511
57proximal/distal pattern formation (GO:0009954)2.62572665
58protein localization to synapse (GO:0035418)2.62121645
59mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.61466898
60embryonic cranial skeleton morphogenesis (GO:0048701)2.60612536
61negative regulation of axon guidance (GO:1902668)2.59976496
62regulation of non-canonical Wnt signaling pathway (GO:2000050)2.59060004
63craniofacial suture morphogenesis (GO:0097094)2.58062235
64semaphorin-plexin signaling pathway (GO:0071526)2.57628548
65establishment of tissue polarity (GO:0007164)2.56960957
66establishment of planar polarity (GO:0001736)2.56960957
67protein heterotrimerization (GO:0070208)2.55852753
68negative regulation of astrocyte differentiation (GO:0048712)2.53647740
69regulation of sister chromatid cohesion (GO:0007063)2.52883171
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.51310062
71regulation of hippo signaling (GO:0035330)2.50508033
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50351634
73positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49692565
74head development (GO:0060322)2.49664954
75gamma-aminobutyric acid transport (GO:0015812)2.49389096
76body morphogenesis (GO:0010171)2.49210778
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48873981
78regulation of axon extension involved in axon guidance (GO:0048841)2.48395282
79fibroblast migration (GO:0010761)2.48363672
80non-canonical Wnt signaling pathway (GO:0035567)2.48104137
81heart morphogenesis (GO:0003007)2.45614712
82mesenchyme development (GO:0060485)2.45599593
83hindlimb morphogenesis (GO:0035137)2.45220854
84embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44867659
85embryonic camera-type eye development (GO:0031076)2.44583284
86regulation of mesoderm development (GO:2000380)2.44477193
87cell proliferation in forebrain (GO:0021846)2.44367756
88central nervous system projection neuron axonogenesis (GO:0021952)2.44348306
89positive regulation of male gonad development (GO:2000020)2.43832607
90regulation of mesenchymal cell proliferation (GO:0010464)2.43476000
91cell adhesion mediated by integrin (GO:0033627)2.43214223
92regulation of heart morphogenesis (GO:2000826)2.43159989
93negative regulation of DNA repair (GO:0045738)2.43087250
94positive regulation of smoothened signaling pathway (GO:0045880)2.43000516
95positive regulation of hormone biosynthetic process (GO:0046886)2.42756574
96regulation of transforming growth factor beta2 production (GO:0032909)2.42273890
97cell migration in hindbrain (GO:0021535)2.42021591
98regulation of axon guidance (GO:1902667)2.41412838
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41063659
100negative chemotaxis (GO:0050919)2.41055320
101positive regulation of mesenchymal cell proliferation (GO:0002053)2.40832402
102lymphangiogenesis (GO:0001946)2.40741604
103dermatan sulfate biosynthetic process (GO:0030208)2.40689685
104nephron epithelium morphogenesis (GO:0072088)2.40452922
105nephron tubule morphogenesis (GO:0072078)2.40452922
106myoblast fusion (GO:0007520)2.39630523
107somite development (GO:0061053)2.39213508
108nuclear pore organization (GO:0006999)2.37437372
109neural tube formation (GO:0001841)2.37290786
110NLS-bearing protein import into nucleus (GO:0006607)2.37075206
111neural crest cell development (GO:0014032)2.36726385
112pericardium development (GO:0060039)2.35800120
113protein polyglutamylation (GO:0018095)2.35318193
114regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.35242954
115anatomical structure regression (GO:0060033)2.35229713
116chondrocyte development (GO:0002063)2.34974974
117cranial nerve morphogenesis (GO:0021602)2.34042499
118positive regulation of epithelial to mesenchymal transition (GO:0010718)2.33150079
119cerebral cortex radially oriented cell migration (GO:0021799)2.31891437
120regulation of posttranscriptional gene silencing (GO:0060147)2.31815778
121regulation of gene silencing by miRNA (GO:0060964)2.31815778
122regulation of gene silencing by RNA (GO:0060966)2.31815778
123embryonic hindlimb morphogenesis (GO:0035116)2.30938352
124axonal fasciculation (GO:0007413)2.30641445
125axon extension (GO:0048675)2.30460686
126embryonic viscerocranium morphogenesis (GO:0048703)2.30356387
127negative regulation of cartilage development (GO:0061037)2.30181041
128corticosteroid receptor signaling pathway (GO:0031958)2.30113467
129cilium morphogenesis (GO:0060271)2.28910224
130gonadal mesoderm development (GO:0007506)2.28827417
131polarized epithelial cell differentiation (GO:0030859)2.28786625
132regulation of male gonad development (GO:2000018)2.28460226
133regulation of secondary heart field cardioblast proliferation (GO:0003266)2.28348908
134regulation of cardioblast proliferation (GO:0003264)2.28348908
135cilium organization (GO:0044782)2.28096431
136artery development (GO:0060840)2.27781245
137positive regulation of gastrulation (GO:2000543)2.27644541
138urogenital system development (GO:0001655)2.27560665
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.27540039
140behavioral response to ethanol (GO:0048149)2.27135298
141cilium assembly (GO:0042384)2.27119672
142negative regulation of protein localization to cell surface (GO:2000009)2.26434693
143kidney morphogenesis (GO:0060993)2.26280196
144layer formation in cerebral cortex (GO:0021819)2.26060333
145hindbrain development (GO:0030902)2.26050922
146renal system development (GO:0072001)2.26046980
147smoothened signaling pathway (GO:0007224)2.24718140
148positive regulation of dendritic spine morphogenesis (GO:0061003)2.23568673
149homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.22262062
150neurotransmitter-gated ion channel clustering (GO:0072578)2.22210175
151calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.21875629
152negative regulation of sodium ion transport (GO:0010766)2.20484111
153intraciliary transport (GO:0042073)2.20403509
154neuron cell-cell adhesion (GO:0007158)2.19801182
155inner ear receptor cell development (GO:0060119)2.18983146
156negative regulation of axon extension (GO:0030517)2.18684039
157transmission of nerve impulse (GO:0019226)2.18021471
158olfactory bulb development (GO:0021772)2.17580565
159spinal cord motor neuron differentiation (GO:0021522)2.14462750
160nucleobase catabolic process (GO:0046113)2.14458259
161embryonic axis specification (GO:0000578)2.13164810
162somite rostral/caudal axis specification (GO:0032525)2.13059513
163renal tubule morphogenesis (GO:0061333)2.12568141
164negative regulation of keratinocyte proliferation (GO:0010839)2.12471558
165acrosome assembly (GO:0001675)2.11633037
166monoubiquitinated protein deubiquitination (GO:0035520)2.11393841
167inner ear receptor stereocilium organization (GO:0060122)2.10127859
168cerebral cortex cell migration (GO:0021795)2.10004723
169regulation of smoothened signaling pathway (GO:0008589)2.09340653
170peristalsis (GO:0030432)2.08742360
171embryonic digit morphogenesis (GO:0042733)2.08098860
172sex differentiation (GO:0007548)2.07620318
173synapse assembly (GO:0007416)2.07602644
174kynurenine metabolic process (GO:0070189)2.06997378
175neuronal action potential propagation (GO:0019227)2.06550156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.63055417
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.48137075
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68561577
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67046206
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44262000
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.41722147
7EZH2_22144423_ChIP-Seq_EOC_Human2.39771811
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39690493
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31486383
10EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.30296270
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.26363882
12TAF15_26573619_Chip-Seq_HEK293_Human2.25834020
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.24509124
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.24115127
15VDR_22108803_ChIP-Seq_LS180_Human2.22315341
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.16452247
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.14414024
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.04575291
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00003407
20P300_19829295_ChIP-Seq_ESCs_Human1.99953927
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97232646
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94019284
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.88288325
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83496642
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81385968
26* ISL1_27105846_Chip-Seq_CPCs_Mouse1.80285455
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78741504
28AR_21572438_ChIP-Seq_LNCaP_Human1.75474776
29* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.72391911
30GBX2_23144817_ChIP-Seq_PC3_Human1.71641879
31BRD4_25478319_ChIP-Seq_HGPS_Human1.70296687
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69581320
33* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68486106
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68434009
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63767360
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.63708702
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.63037353
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.59263172
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57859084
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57579317
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56516149
42IGF1R_20145208_ChIP-Seq_DFB_Human1.55541552
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52761566
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52599346
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52599346
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.51203065
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.51083295
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50871734
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50766105
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.49106886
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.47943552
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.46111402
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.45475816
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44325393
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42698855
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41222497
57CLOCK_20551151_ChIP-Seq_293T_Human1.41022839
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40677559
59ER_23166858_ChIP-Seq_MCF-7_Human1.40445320
60AR_25329375_ChIP-Seq_VCAP_Human1.39465520
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39268596
62* TCF4_23295773_ChIP-Seq_U87_Human1.39184278
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37923330
64* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37640750
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.36325458
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.35206299
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34524635
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33578411
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33466437
70TP53_16413492_ChIP-PET_HCT116_Human1.32794656
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.32000614
72AHR_22903824_ChIP-Seq_MCF-7_Human1.31902777
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31559883
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.30004070
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29316967
76CJUN_26792858_Chip-Seq_BT549_Human1.29299388
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29152159
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29152159
79BCAT_22108803_ChIP-Seq_LS180_Human1.28143883
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27549781
81NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26976999
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26803603
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.25049357
84* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24458326
85RUNX2_22187159_ChIP-Seq_PCA_Human1.24386661
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23767417
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23672457
88CBP_20019798_ChIP-Seq_JUKART_Human1.23672457
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23106089
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21856445
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21787762
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21787762
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21785771
94TP53_18474530_ChIP-ChIP_U2OS_Human1.20717343
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20627694
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20536979
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20196943
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19806442
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.19529840
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18847649
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17221508
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16479856
103RXR_22108803_ChIP-Seq_LS180_Human1.16179669
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16174648
105SOX9_26525672_Chip-Seq_HEART_Mouse1.16174261
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16062445
107NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14713264
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14482203
109REST_21632747_ChIP-Seq_MESCs_Mouse1.14302937
110ZNF274_21170338_ChIP-Seq_K562_Hela1.13377707
111RNF2_27304074_Chip-Seq_NSC_Mouse1.13344537
112* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13136321
113FUS_26573619_Chip-Seq_HEK293_Human1.12581902
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12186224
115* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11833061
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11630916
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10790025
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10308550
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.09847934
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09500159
121TCF4_22108803_ChIP-Seq_LS180_Human1.08831180
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07572077
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07560425
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06704639
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06681982
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06182063
127* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06131271
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05653068
129AR_19668381_ChIP-Seq_PC3_Human1.04868912
130TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04431541
131EWS_26573619_Chip-Seq_HEK293_Human1.04293386
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03007748
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02879817
134TP53_20018659_ChIP-ChIP_R1E_Mouse1.02849332
135STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02277014
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01351572
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01162317
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.00682510
139* SMAD4_21799915_ChIP-Seq_A2780_Human1.00675280
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99848373
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.98373116
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97553210
143* STAT3_23295773_ChIP-Seq_U87_Human0.97475160
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97033882
145E2F7_22180533_ChIP-Seq_HELA_Human0.96929942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.34156937
2MP0008438_abnormal_cutaneous_collagen3.05490314
3MP0005503_abnormal_tendon_morphology2.65205160
4MP0000537_abnormal_urethra_morphology2.62283184
5MP0003136_yellow_coat_color2.46202792
6MP0003122_maternal_imprinting2.32797430
7MP0003705_abnormal_hypodermis_morpholog2.32455453
8MP0003121_genomic_imprinting2.30631960
9MP0000566_synostosis2.28232286
10MP0009053_abnormal_anal_canal2.27888127
11MP0003385_abnormal_body_wall2.22085445
12MP0003942_abnormal_urinary_system2.10201478
13MP0004272_abnormal_basement_membrane2.04978760
14MP0004885_abnormal_endolymph1.93974825
15MP0005257_abnormal_intraocular_pressure1.93698988
16MP0003937_abnormal_limbs/digits/tail_de1.92746413
17MP0009250_abnormal_appendicular_skeleto1.87705726
18MP0005275_abnormal_skin_tensile1.86882914
19MP0000534_abnormal_ureter_morphology1.84843324
20MP0003123_paternal_imprinting1.84183984
21MP0005076_abnormal_cell_differentiation1.82596142
22MP0005623_abnormal_meninges_morphology1.81632771
23MP0001299_abnormal_eye_distance/1.81525345
24MP0003890_abnormal_embryonic-extraembry1.76325646
25MP0000733_abnormal_muscle_development1.72069751
26MP0005248_abnormal_Harderian_gland1.71091105
27MP0000049_abnormal_middle_ear1.70255063
28MP0003755_abnormal_palate_morphology1.68984946
29MP0003115_abnormal_respiratory_system1.68646450
30MP0003935_abnormal_craniofacial_develop1.64070786
31MP0000428_abnormal_craniofacial_morphol1.60207217
32MP0002249_abnormal_larynx_morphology1.58860964
33MP0005508_abnormal_skeleton_morphology1.57489588
34MP0002116_abnormal_craniofacial_bone1.56759607
35* MP0002938_white_spotting1.56216427
36MP0002932_abnormal_joint_morphology1.55454271
37MP0005551_abnormal_eye_electrophysiolog1.54254864
38MP0002282_abnormal_trachea_morphology1.54103632
39MP0000516_abnormal_urinary_system1.53304850
40MP0005367_renal/urinary_system_phenotyp1.53304850
41* MP0000569_abnormal_digit_pigmentation1.52553965
42MP0000427_abnormal_hair_cycle1.50754351
43MP0003787_abnormal_imprinting1.49038857
44MP0002233_abnormal_nose_morphology1.47685892
45MP0004133_heterotaxia1.47578062
46MP0006072_abnormal_retinal_apoptosis1.45400005
47MP0003283_abnormal_digestive_organ1.44703755
48MP0002653_abnormal_ependyma_morphology1.44335499
49MP0003941_abnormal_skin_development1.42986129
50MP0000432_abnormal_head_morphology1.40486027
51MP0005187_abnormal_penis_morphology1.36936871
52MP0003119_abnormal_digestive_system1.36529880
53MP0000955_abnormal_spinal_cord1.35075410
54MP0002697_abnormal_eye_size1.34025006
55MP0009046_muscle_twitch1.33922822
56MP0001849_ear_inflammation1.32632184
57MP0002184_abnormal_innervation1.30426827
58MP0006054_spinal_hemorrhage1.30383001
59MP0009384_cardiac_valve_regurgitation1.29947174
60MP0006292_abnormal_olfactory_placode1.29350303
61MP0001293_anophthalmia1.28593743
62MP0005253_abnormal_eye_physiology1.28279260
63MP0000778_abnormal_nervous_system1.27937086
64MP0005171_absent_coat_pigmentation1.26684990
65MP0008877_abnormal_DNA_methylation1.25850182
66MP0002177_abnormal_outer_ear1.25510248
67MP0001958_emphysema1.25119731
68MP0002896_abnormal_bone_mineralization1.23358327
69MP0002102_abnormal_ear_morphology1.20456212
70MP0003091_abnormal_cell_migration1.19650457
71MP0001529_abnormal_vocalization1.18578683
72MP0002084_abnormal_developmental_patter1.18359098
73MP0004197_abnormal_fetal_growth/weight/1.18070034
74MP0006276_abnormal_autonomic_nervous1.18045946
75MP0002735_abnormal_chemical_nociception1.17759481
76* MP0002557_abnormal_social/conspecific_i1.17403202
77MP0004134_abnormal_chest_morphology1.15834823
78MP0010352_gastrointestinal_tract_polyps1.15132090
79MP0001485_abnormal_pinna_reflex1.15007444
80* MP0002109_abnormal_limb_morphology1.13613095
81MP0002092_abnormal_eye_morphology1.13495660
82MP0003861_abnormal_nervous_system1.12046182
83MP0001486_abnormal_startle_reflex1.11588330
84MP0000462_abnormal_digestive_system1.09596212
85MP0000647_abnormal_sebaceous_gland1.09536634
86MP0002572_abnormal_emotion/affect_behav1.09232064
87MP0002089_abnormal_postnatal_growth/wei1.09228016
88MP0005195_abnormal_posterior_eye1.09066322
89MP0001286_abnormal_eye_development1.09044439
90MP0002234_abnormal_pharynx_morphology1.08375499
91MP0003315_abnormal_perineum_morphology1.08295787
92MP0001984_abnormal_olfaction1.08277274
93MP0005197_abnormal_uvea_morphology1.06496402
94MP0003880_abnormal_central_pattern1.06396654
95MP0002272_abnormal_nervous_system1.05149436
96MP0002085_abnormal_embryonic_tissue1.04520226
97MP0000163_abnormal_cartilage_morphology1.04178101
98MP0005391_vision/eye_phenotype1.03995843
99MP0002152_abnormal_brain_morphology1.03692022
100MP0002882_abnormal_neuron_morphology1.03252262
101MP0002160_abnormal_reproductive_system1.03027665
102MP0002752_abnormal_somatic_nervous1.02825848
103MP0003635_abnormal_synaptic_transmissio1.01610520
104MP0009745_abnormal_behavioral_response1.01544147
105MP0000026_abnormal_inner_ear1.01382647
106MP0001968_abnormal_touch/_nociception1.00580828
107MP0003279_aneurysm1.00392670
108MP0001270_distended_abdomen1.00279889
109MP0002108_abnormal_muscle_morphology1.00060393
110MP0004924_abnormal_behavior0.99736906
111MP0005386_behavior/neurological_phenoty0.99736906
112MP0002114_abnormal_axial_skeleton0.99599396
113MP0002638_abnormal_pupillary_reflex0.99491092
114MP0002063_abnormal_learning/memory/cond0.98841344
115MP0003567_abnormal_fetal_cardiomyocyte0.98073489
116MP0002736_abnormal_nociception_after0.98023922
117MP0009703_decreased_birth_body0.96912165
118MP0002115_abnormal_skeleton_extremities0.96607332
119MP0002928_abnormal_bile_duct0.96280786
120MP0002067_abnormal_sensory_capabilities0.95470089
121MP0001324_abnormal_eye_pigmentation0.94062142
122MP0002111_abnormal_tail_morphology0.93800223
123MP0008007_abnormal_cellular_replicative0.93775805
124MP0010368_abnormal_lymphatic_system0.93425082
125MP0004142_abnormal_muscle_tone0.93077163
126MP0002734_abnormal_mechanical_nocicepti0.91151873
127MP0003950_abnormal_plasma_membrane0.91036491
128MP0008789_abnormal_olfactory_epithelium0.90968746
129MP0002113_abnormal_skeleton_development0.90937782
130MP0000538_abnormal_urinary_bladder0.89173328
131MP0004859_abnormal_synaptic_plasticity0.88079389
132MP0002751_abnormal_autonomic_nervous0.87753357
133MP0002081_perinatal_lethality0.86194040
134MP0002925_abnormal_cardiovascular_devel0.85199647
135MP0004233_abnormal_muscle_weight0.84495101
136MP0000631_abnormal_neuroendocrine_gland0.84475144
137MP0004043_abnormal_pH_regulation0.83870245
138MP0000383_abnormal_hair_follicle0.83658462
139MP0005408_hypopigmentation0.82758892
140MP0002064_seizures0.80919093
141MP0009780_abnormal_chondrocyte_physiolo0.80827100
142MP0010386_abnormal_urinary_bladder0.79805346
143MP0000767_abnormal_smooth_muscle0.79638581
144MP0002168_other_aberrant_phenotype0.79484034
145MP0000762_abnormal_tongue_morphology0.78485264
146MP0001346_abnormal_lacrimal_gland0.78241445
147MP0001915_intracranial_hemorrhage0.77942826
148MP0008995_early_reproductive_senescence0.77890914
149MP0001340_abnormal_eyelid_morphology0.77777126
150MP0003566_abnormal_cell_adhesion0.77723345

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.94279805
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.94279805
3Shallow orbits (HP:0000586)3.40653182
4Pancreatic fibrosis (HP:0100732)3.20251186
5Hyperventilation (HP:0002883)3.15123747
6True hermaphroditism (HP:0010459)3.15087383
7Protrusio acetabuli (HP:0003179)3.10151147
8Abnormality of the 4th metacarpal (HP:0010012)3.02664119
9Pancreatic cysts (HP:0001737)2.93368688
10Renal duplication (HP:0000075)2.90790784
11Genetic anticipation (HP:0003743)2.72547092
12Abnormality of midbrain morphology (HP:0002418)2.68310918
13Molar tooth sign on MRI (HP:0002419)2.68310918
14Nephronophthisis (HP:0000090)2.67811821
15Chronic hepatic failure (HP:0100626)2.63182123
16Bladder diverticulum (HP:0000015)2.58063477
17Ankle contracture (HP:0006466)2.56169235
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.52792865
19Midline defect of the nose (HP:0004122)2.51973132
20Progressive cerebellar ataxia (HP:0002073)2.49496784
21Premature rupture of membranes (HP:0001788)2.47890780
22Renovascular hypertension (HP:0100817)2.47537689
23Abnormality of the renal medulla (HP:0100957)2.47369925
24Atrophic scars (HP:0001075)2.37434138
25Aortic aneurysm (HP:0004942)2.29945070
26Medial flaring of the eyebrow (HP:0010747)2.26665512
27Elfin facies (HP:0004428)2.26194417
28Hyperacusis (HP:0010780)2.26137750
29Genital tract atresia (HP:0001827)2.25852662
30Protruding tongue (HP:0010808)2.24452786
31Drooling (HP:0002307)2.24293629
32Cerebellar dysplasia (HP:0007033)2.22483850
33Cutaneous finger syndactyly (HP:0010554)2.22367485
34Trigonocephaly (HP:0000243)2.21538949
35Preaxial foot polydactyly (HP:0001841)2.21012617
36Vaginal atresia (HP:0000148)2.19078865
37Aortic dissection (HP:0002647)2.18712347
38Cerebral aneurysm (HP:0004944)2.18615708
39Chorioretinal atrophy (HP:0000533)2.17578480
40Wrist flexion contracture (HP:0001239)2.17233659
41Bowel diverticulosis (HP:0005222)2.17038250
42Syringomyelia (HP:0003396)2.16852538
43Spinal cord lesions (HP:0100561)2.16852538
44Fair hair (HP:0002286)2.15722314
45Cystic liver disease (HP:0006706)2.15277079
46Type II lissencephaly (HP:0007260)2.15143982
47Rectal prolapse (HP:0002035)2.13537865
48Gait imbalance (HP:0002141)2.13262316
49Fibular hypoplasia (HP:0003038)2.10905906
50Abnormality of the ischium (HP:0003174)2.09687691
51Abnormality of dentin (HP:0010299)2.08027368
52Deviation of the hallux (HP:0010051)2.07279804
53Gaze-evoked nystagmus (HP:0000640)2.06007294
54Hepatoblastoma (HP:0002884)2.05713049
55Soft skin (HP:0000977)2.05484106
56Flat cornea (HP:0007720)2.05366825
57Anophthalmia (HP:0000528)2.04407975
58Congenital primary aphakia (HP:0007707)2.04168198
59Asymmetry of the thorax (HP:0001555)2.03472131
60Volvulus (HP:0002580)2.03359942
61Absent frontal sinuses (HP:0002688)2.03088994
62Increased nuchal translucency (HP:0010880)2.01993212
63Small hand (HP:0200055)2.01859938
64Papillary thyroid carcinoma (HP:0002895)2.01609258
65Morphological abnormality of the middle ear (HP:0008609)2.00415850
66Macroorchidism (HP:0000053)1.99946537
67Narrow palate (HP:0000189)1.99803174
68Subacute progressive viral hepatitis (HP:0006572)1.99730667
69Short foot (HP:0001773)1.99398316
70Postaxial foot polydactyly (HP:0001830)1.98448641
71Keratoconus (HP:0000563)1.98144605
72Increased corneal curvature (HP:0100692)1.98144605
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.97957630
74Hallux valgus (HP:0001822)1.97200453
75Broad thumb (HP:0011304)1.96930982
76Neonatal short-limb short stature (HP:0008921)1.95290897
77Cutaneous syndactyly (HP:0012725)1.95084011
78Abnormality of the nasal septum (HP:0000419)1.94440258
79Mesomelia (HP:0003027)1.93534381
80Tubular atrophy (HP:0000092)1.93518581
81Bell-shaped thorax (HP:0001591)1.93090487
82Postaxial hand polydactyly (HP:0001162)1.90988184
83Hypoplastic labia majora (HP:0000059)1.90526342
84Overriding aorta (HP:0002623)1.90160633
85Broad metatarsal (HP:0001783)1.89759216
86Excessive salivation (HP:0003781)1.88271818
87Broad-based gait (HP:0002136)1.87636443
88Exostoses (HP:0100777)1.87005329
89Patellar aplasia (HP:0006443)1.86593950
90Mitral valve prolapse (HP:0001634)1.85338182
91Febrile seizures (HP:0002373)1.84584950
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.83678802
93Broad long bones (HP:0005622)1.83271265
94Lymphangioma (HP:0100764)1.83238268
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.83046575
96Buphthalmos (HP:0000557)1.82975041
97Preaxial hand polydactyly (HP:0001177)1.82438213
98Poor coordination (HP:0002370)1.82112308
99Focal seizures (HP:0007359)1.82104996
100Sclerocornea (HP:0000647)1.80889517
101Nephrogenic diabetes insipidus (HP:0009806)1.80269111
102Hypoplastic ischia (HP:0003175)1.80228726
103Coronal craniosynostosis (HP:0004440)1.79363520
104Dilatation of the ascending aorta (HP:0005111)1.78799401
105Broad phalanges of the hand (HP:0009768)1.78502135
106Lissencephaly (HP:0001339)1.78300372
107Broad finger (HP:0001500)1.78269146
108Abnormality of the renal cortex (HP:0011035)1.77984910
109Bifid tongue (HP:0010297)1.77510354
110Abnormality of the distal phalanx of the thumb (HP:0009617)1.77239877
111Abnormality of the labia majora (HP:0012881)1.76721064
112Intestinal atresia (HP:0011100)1.76250231
113Broad phalanx (HP:0006009)1.76078880
114Obsessive-compulsive behavior (HP:0000722)1.75633518
115Short tibia (HP:0005736)1.75057937
116Aplasia/Hypoplasia of the patella (HP:0006498)1.73872492
117Overgrowth (HP:0001548)1.73112935
118Abnormality of the diencephalon (HP:0010662)1.73098151
119Enlarged penis (HP:0000040)1.72042560
120Germ cell neoplasia (HP:0100728)1.70565843
121Focal motor seizures (HP:0011153)1.70466249
122Occipital encephalocele (HP:0002085)1.69533814
123Congenital hepatic fibrosis (HP:0002612)1.68352808
124Joint laxity (HP:0001388)1.68305979
125Hemiparesis (HP:0001269)1.68299212
126Abnormality of the right ventricle (HP:0001707)1.68087337
127Anencephaly (HP:0002323)1.67664596
128Arterial tortuosity (HP:0005116)1.66497526
129Gastrointestinal atresia (HP:0002589)1.66363237
130Microglossia (HP:0000171)1.65856646
131Highly arched eyebrow (HP:0002553)1.65758670
132Concave nail (HP:0001598)1.65701867
133Hypoplasia of the maxilla (HP:0000327)1.65531774
134Congenital stationary night blindness (HP:0007642)1.65411072
135Absent speech (HP:0001344)1.64490622
136Patellar dislocation (HP:0002999)1.63864283
137Leiomyosarcoma (HP:0100243)1.63849474
138Uterine leiomyosarcoma (HP:0002891)1.63849474
139Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60866124
140Increased number of teeth (HP:0011069)1.60616365
141Megalencephaly (HP:0001355)1.60426656
142Vascular tortuosity (HP:0004948)1.60288917
143Astrocytoma (HP:0009592)1.59780140
144Abnormality of the astrocytes (HP:0100707)1.59780140
145Micropenis (HP:0000054)1.59527934
146Broad ribs (HP:0000885)1.59230891
147Genu recurvatum (HP:0002816)1.59187750
148Fragile skin (HP:0001030)1.58884769
149Megalocornea (HP:0000485)1.58744707
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57774565
151Dental malocclusion (HP:0000689)1.57482180
152Wide anterior fontanel (HP:0000260)1.56421894
153Vitreoretinal degeneration (HP:0000655)1.56325577
154Long eyelashes (HP:0000527)1.56102565
155Supernumerary spleens (HP:0009799)1.55705566
156Smooth philtrum (HP:0000319)1.55482853
157Bulbous nose (HP:0000414)1.55373178
158Follicular hyperkeratosis (HP:0007502)1.55242045
159Transitional cell carcinoma of the bladder (HP:0006740)1.55229666
160Turricephaly (HP:0000262)1.54266775
161Wormian bones (HP:0002645)1.54253140
162Renal dysplasia (HP:0000110)1.53782779
163Dandy-Walker malformation (HP:0001305)1.53718726
164Shawl scrotum (HP:0000049)1.52581000
165Abnormality of the pubic bones (HP:0003172)1.51999364
166Generalized hypopigmentation of hair (HP:0011358)1.51918650
167Hypoplastic iliac wings (HP:0002866)1.51806896
168Anterior segment dysgenesis (HP:0007700)1.51094609
169Pachygyria (HP:0001302)1.50828289
170Aplasia/Hypoplasia of the lens (HP:0008063)1.50759485
171Aneurysm (HP:0002617)1.49807190
172Bilateral microphthalmos (HP:0007633)1.49553661
173Abnormality of the radial head (HP:0003995)1.49071020
174Synostosis of carpal bones (HP:0005048)1.48810190
175Broad toe (HP:0001837)1.48608579
176Congenital glaucoma (HP:0001087)1.48511963
177Blue irides (HP:0000635)1.48452921
178Cortical dysplasia (HP:0002539)1.48444609
179Spina bifida occulta (HP:0003298)1.48375620
180Deviation of the thumb (HP:0009603)1.48280474
181Optic nerve hypoplasia (HP:0000609)1.48245970
182Abnormality of the fibula (HP:0002991)1.47482533
183Oligodactyly (hands) (HP:0001180)1.47461100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.22855188
2PNCK4.09551031
3CASK3.35221245
4DDR22.77056837
5EPHB22.65392943
6ERBB32.49070918
7PDGFRA2.45250749
8LMTK22.36824871
9AKT32.34478389
10CDK122.23637561
11KSR12.21740838
12WNK42.11771888
13MARK12.01808766
14SIK11.98138011
15LATS21.96567842
16CAMK1D1.94293437
17BRD41.91092612
18CAMK1G1.86226118
19TTN1.67273224
20TRIB31.64696666
21CDC71.62397377
22ADRBK21.62264726
23STK31.60207115
24FRK1.59144832
25SIK31.57434670
26TNIK1.57362009
27FGFR21.56157910
28RIPK11.55818072
29WEE11.53768346
30STK391.52445311
31EPHA31.45505898
32PIK3CA1.44599143
33FGFR11.43695608
34MKNK11.39960809
35GRK11.36324086
36PTK61.34767907
37PKN21.33361744
38MAP2K71.32485918
39STK38L1.29981260
40EEF2K1.26452404
41ZAK1.24111053
42MTOR1.21295212
43NUAK11.19716747
44PAK21.18760105
45TGFBR11.18679983
46NTRK31.18238990
47BCR1.15211899
48FER1.15210170
49TLK11.15184072
50DYRK21.15111518
51PTK21.10886043
52DYRK1B1.09584409
53TYRO31.08033565
54BRSK21.07285441
55PDGFRB1.07066713
56DMPK1.04795117
57OXSR11.03794881
58BMPR1B1.02287064
59CDK60.99770798
60MAP3K100.99168448
61WNK30.99017807
62PAK30.98924463
63ICK0.97422926
64SIK20.95136596
65WNK10.90985488
66PAK60.90907455
67PINK10.89404751
68CDC42BPA0.89131088
69NTRK20.87216253
70ROCK10.86820312
71INSRR0.86254563
72ADRBK10.84875516
73PAK40.84774867
74DYRK30.84507080
75NTRK10.84119492
76* ERBB20.83154686
77PRKCG0.82705093
78ACVR1B0.82206893
79MAP4K20.81329520
80CAMKK20.80618089
81PRKCE0.79547759
82CDK90.79314029
83CSNK1G20.78819217
84RET0.78069170
85CSNK1A1L0.76721764
86ATR0.75616036
87PRKD30.75221114
88MAPK130.74013831
89NEK20.73911728
90SGK4940.73874485
91SGK2230.73874485
92EPHA40.73563127
93MAP3K40.73079423
94PKN10.72514942
95FGFR30.72086104
96TTK0.71611128
97PLK20.70403605
98MKNK20.69133217
99BMX0.68947950
100PLK30.67802594
101PASK0.66736308
102MAPK150.66572456
103CHUK0.66489493
104CSNK1G10.63026371
105ATM0.62970246
106CHEK20.62536945
107MAP2K40.62277904
108ERBB40.61811112
109MAP3K20.60656973
110MELK0.60010339
111LIMK10.59840601
112SGK20.59475266
113RPS6KA20.59430387
114MAPKAPK50.57655592
115CDK80.55408949
116SRPK10.54959904
117CHEK10.54578012
118CDK10.54375725
119SGK30.54087951
120PTK2B0.54019234
121TRIM280.50775163
122RPS6KA40.50353387
123AKT10.49604379
124TAF10.47459139
125CDK70.47441754
126CAMK2A0.46027125
127CAMK10.44958446
128MAPK80.44793695
129NEK90.44495494
130MET0.44089557
131PRKDC0.43022558
132FLT30.41936742
133STK380.40989629
134PRKAA20.40892188
135CSNK1D0.40670750
136CDK20.40145408
137CSNK1G30.39255570
138AURKB0.38530326
139MINK10.38134255
140* GSK3B0.38132102
141TSSK60.37681021
142* MAPK140.37424313
143DYRK1A0.36392827
144CDK50.35884969
145PLK10.34712939
146PRKAA10.33944238
147CDK30.33827751
148SGK10.33765200
149CAMK2B0.33631106
150CAMK40.33038585
151CSNK1E0.32435835

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.63293017
2Nicotine addiction_Homo sapiens_hsa050332.58832836
3Hippo signaling pathway_Homo sapiens_hsa043902.27648717
4Adherens junction_Homo sapiens_hsa045202.27393859
5ECM-receptor interaction_Homo sapiens_hsa045122.25844016
6Hedgehog signaling pathway_Homo sapiens_hsa043402.12086465
7MicroRNAs in cancer_Homo sapiens_hsa052061.98630680
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.96175736
9TGF-beta signaling pathway_Homo sapiens_hsa043501.91813757
10Phototransduction_Homo sapiens_hsa047441.90047107
11Axon guidance_Homo sapiens_hsa043601.88018245
12Focal adhesion_Homo sapiens_hsa045101.82986037
13Colorectal cancer_Homo sapiens_hsa052101.81803754
14Proteoglycans in cancer_Homo sapiens_hsa052051.81144599
15Endometrial cancer_Homo sapiens_hsa052131.77946866
16Small cell lung cancer_Homo sapiens_hsa052221.74323520
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.73371802
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68697346
19Glutamatergic synapse_Homo sapiens_hsa047241.67653619
20Chronic myeloid leukemia_Homo sapiens_hsa052201.67540052
21Wnt signaling pathway_Homo sapiens_hsa043101.64366384
22Notch signaling pathway_Homo sapiens_hsa043301.62209542
23Cell cycle_Homo sapiens_hsa041101.61598348
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60516463
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55593655
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51769788
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51470670
28Butanoate metabolism_Homo sapiens_hsa006501.48892291
29Nitrogen metabolism_Homo sapiens_hsa009101.47995055
30Morphine addiction_Homo sapiens_hsa050321.46159287
31Taste transduction_Homo sapiens_hsa047421.44712536
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.43967106
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40921456
34Circadian entrainment_Homo sapiens_hsa047131.39615116
35Steroid biosynthesis_Homo sapiens_hsa001001.38617225
36Lysine degradation_Homo sapiens_hsa003101.38558396
37Pancreatic cancer_Homo sapiens_hsa052121.37927814
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37595622
39Selenocompound metabolism_Homo sapiens_hsa004501.36956291
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35746318
41Viral myocarditis_Homo sapiens_hsa054161.35483254
42GABAergic synapse_Homo sapiens_hsa047271.34317600
43mRNA surveillance pathway_Homo sapiens_hsa030151.34108964
44Melanoma_Homo sapiens_hsa052181.31823032
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30843753
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29912808
47Glioma_Homo sapiens_hsa052141.29449407
48Basal transcription factors_Homo sapiens_hsa030221.27946549
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27458144
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.26971960
51Bladder cancer_Homo sapiens_hsa052191.25509844
52Prostate cancer_Homo sapiens_hsa052151.25464284
53Linoleic acid metabolism_Homo sapiens_hsa005911.25150564
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24066547
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23195819
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21645026
57Melanogenesis_Homo sapiens_hsa049161.21368189
58mTOR signaling pathway_Homo sapiens_hsa041501.20168806
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19870332
60Pathways in cancer_Homo sapiens_hsa052001.18773924
61ABC transporters_Homo sapiens_hsa020101.18038798
62Protein digestion and absorption_Homo sapiens_hsa049741.17365896
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16015407
64Amoebiasis_Homo sapiens_hsa051461.15836910
65Fatty acid biosynthesis_Homo sapiens_hsa000611.14373285
66Insulin secretion_Homo sapiens_hsa049111.13325355
67Tight junction_Homo sapiens_hsa045301.12212688
68Serotonergic synapse_Homo sapiens_hsa047261.10382181
69Dilated cardiomyopathy_Homo sapiens_hsa054141.10354223
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10312371
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08631595
72Cholinergic synapse_Homo sapiens_hsa047251.07531083
73Tryptophan metabolism_Homo sapiens_hsa003801.06683921
74HTLV-I infection_Homo sapiens_hsa051661.01881517
75Oocyte meiosis_Homo sapiens_hsa041141.01563244
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01427997
77Ether lipid metabolism_Homo sapiens_hsa005651.01291303
78Renal cell carcinoma_Homo sapiens_hsa052111.00721773
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.99070207
80ErbB signaling pathway_Homo sapiens_hsa040120.98984062
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97318234
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94198583
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93844354
84Amphetamine addiction_Homo sapiens_hsa050310.89842510
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.89246252
86Prolactin signaling pathway_Homo sapiens_hsa049170.88980206
87Type II diabetes mellitus_Homo sapiens_hsa049300.88876496
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88769561
89Alcoholism_Homo sapiens_hsa050340.88669405
90Dorso-ventral axis formation_Homo sapiens_hsa043200.88484425
91Non-small cell lung cancer_Homo sapiens_hsa052230.88465002
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87206917
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86898663
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85109435
95Estrogen signaling pathway_Homo sapiens_hsa049150.84546429
96Ovarian steroidogenesis_Homo sapiens_hsa049130.83983709
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83913147
98Gap junction_Homo sapiens_hsa045400.83856496
99p53 signaling pathway_Homo sapiens_hsa041150.83855649
100Olfactory transduction_Homo sapiens_hsa047400.83841217
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83751231
102Rap1 signaling pathway_Homo sapiens_hsa040150.82483130
103FoxO signaling pathway_Homo sapiens_hsa040680.82347731
104Calcium signaling pathway_Homo sapiens_hsa040200.79899592
105Propanoate metabolism_Homo sapiens_hsa006400.78488312
106AMPK signaling pathway_Homo sapiens_hsa041520.76753147
107Salivary secretion_Homo sapiens_hsa049700.75313498
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.73178023
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.72239663
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71291612
111Protein export_Homo sapiens_hsa030600.70482073
112GnRH signaling pathway_Homo sapiens_hsa049120.70149734
113Hepatitis B_Homo sapiens_hsa051610.69898499
114Toxoplasmosis_Homo sapiens_hsa051450.69295978
115Homologous recombination_Homo sapiens_hsa034400.69119367
116Thyroid cancer_Homo sapiens_hsa052160.68364193
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68113730
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67496480
119Thyroid hormone synthesis_Homo sapiens_hsa049180.65615331
120Gastric acid secretion_Homo sapiens_hsa049710.64807889
121RNA transport_Homo sapiens_hsa030130.64127581
122Viral carcinogenesis_Homo sapiens_hsa052030.63318479
123Insulin signaling pathway_Homo sapiens_hsa049100.63070427
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59926091
125TNF signaling pathway_Homo sapiens_hsa046680.59688525
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59359702
127VEGF signaling pathway_Homo sapiens_hsa043700.56744704
128Choline metabolism in cancer_Homo sapiens_hsa052310.56241166
129Insulin resistance_Homo sapiens_hsa049310.55306103
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.54499693
131Circadian rhythm_Homo sapiens_hsa047100.54239573
132Histidine metabolism_Homo sapiens_hsa003400.53365795
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52645586
134MAPK signaling pathway_Homo sapiens_hsa040100.52581335
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52353471
136Fanconi anemia pathway_Homo sapiens_hsa034600.51791391
137Retinol metabolism_Homo sapiens_hsa008300.51286078
138Salmonella infection_Homo sapiens_hsa051320.50546500
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50043789
140N-Glycan biosynthesis_Homo sapiens_hsa005100.49836859
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49758150
142Platelet activation_Homo sapiens_hsa046110.49273786
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.48246719
144cAMP signaling pathway_Homo sapiens_hsa040240.48121786
145Ras signaling pathway_Homo sapiens_hsa040140.47860512
146Cocaine addiction_Homo sapiens_hsa050300.47575590
147Shigellosis_Homo sapiens_hsa051310.46835673
148Renin secretion_Homo sapiens_hsa049240.46500623
149Spliceosome_Homo sapiens_hsa030400.46444142
150beta-Alanine metabolism_Homo sapiens_hsa004100.45940616
151Dopaminergic synapse_Homo sapiens_hsa047280.45482311
152Oxytocin signaling pathway_Homo sapiens_hsa049210.44813560
153Long-term depression_Homo sapiens_hsa047300.44095412

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