DOCK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.51271238
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.54461946
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50409732
4desmosome organization (GO:0002934)4.47472600
5vocalization behavior (GO:0071625)4.40972259
6synaptic vesicle maturation (GO:0016188)4.40350550
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.26115810
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20006179
9endothelium development (GO:0003158)4.18130925
10neuronal action potential propagation (GO:0019227)4.05580936
11hemidesmosome assembly (GO:0031581)4.01638559
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01283753
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00336989
14exploration behavior (GO:0035640)3.93663005
15glutamate secretion (GO:0014047)3.81340403
16glutamate receptor signaling pathway (GO:0007215)3.80376884
17synaptic vesicle exocytosis (GO:0016079)3.73496906
18regulation of glutamate receptor signaling pathway (GO:1900449)3.67261068
19neuron cell-cell adhesion (GO:0007158)3.66859615
20cellular potassium ion homeostasis (GO:0030007)3.66770559
21sodium ion export (GO:0071436)3.59312052
22layer formation in cerebral cortex (GO:0021819)3.59301475
23L-amino acid import (GO:0043092)3.57231205
24regulation of synaptic vesicle exocytosis (GO:2000300)3.55405671
25dendritic spine morphogenesis (GO:0060997)3.54330161
26synaptic transmission, glutamatergic (GO:0035249)3.51490335
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46176328
28transmission of nerve impulse (GO:0019226)3.45190771
29regulation of neuronal synaptic plasticity (GO:0048168)3.40871738
30neuron recognition (GO:0008038)3.35089003
31surfactant homeostasis (GO:0043129)3.31335346
32long-term memory (GO:0007616)3.29707088
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29298204
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.27814660
35gamma-aminobutyric acid transport (GO:0015812)3.27206401
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26402602
37protein localization to synapse (GO:0035418)3.25567803
38neuron-neuron synaptic transmission (GO:0007270)3.25479550
39regulation of synapse structural plasticity (GO:0051823)3.23754488
40neurotransmitter secretion (GO:0007269)3.20247156
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18434697
42dendrite morphogenesis (GO:0048813)3.16636828
43regulation of dendritic spine morphogenesis (GO:0061001)3.13394081
44cerebellar granule cell differentiation (GO:0021707)3.12621138
45regulation of synaptic vesicle transport (GO:1902803)3.12104869
46axonal fasciculation (GO:0007413)3.10138973
47potassium ion import (GO:0010107)3.09273051
48cell-substrate junction assembly (GO:0007044)3.08332395
49establishment of skin barrier (GO:0061436)3.06818963
50gamma-aminobutyric acid signaling pathway (GO:0007214)3.02054186
51regulation of postsynaptic membrane potential (GO:0060078)3.00737188
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.00589158
53neuromuscular process controlling balance (GO:0050885)2.98461200
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95580330
55establishment of nucleus localization (GO:0040023)2.95362744
56cell communication by electrical coupling (GO:0010644)2.94917585
57activation of protein kinase A activity (GO:0034199)2.94670509
58positive regulation of synapse maturation (GO:0090129)2.93814651
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92934599
60regulation of synaptic plasticity (GO:0048167)2.92633929
61long-term synaptic potentiation (GO:0060291)2.92304481
62blood vessel maturation (GO:0001955)2.91172290
63neurotransmitter-gated ion channel clustering (GO:0072578)2.90428138
64positive regulation of membrane potential (GO:0045838)2.90338087
65dendritic spine organization (GO:0097061)2.88003871
66amino acid import (GO:0043090)2.87870760
67regulation of water loss via skin (GO:0033561)2.87698185
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.86919900
69positive regulation of Rap GTPase activity (GO:0032854)2.85719533
70neuronal ion channel clustering (GO:0045161)2.85645131
71proline transport (GO:0015824)2.85114324
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82200123
73chemical homeostasis within a tissue (GO:0048875)2.81432388
74lymphangiogenesis (GO:0001946)2.81425482
75cerebellar Purkinje cell differentiation (GO:0021702)2.81161835
76keratinization (GO:0031424)2.80910265
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78775946
78regulation of ARF protein signal transduction (GO:0032012)2.76299812
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73591220
80glycine transport (GO:0015816)2.71425157
81long term synaptic depression (GO:0060292)2.70913213
82cellular sodium ion homeostasis (GO:0006883)2.70040973
83neurotransmitter transport (GO:0006836)2.69990525
84regulation of Rap GTPase activity (GO:0032317)2.69532803
85membrane depolarization (GO:0051899)2.68884174
86phospholipid translocation (GO:0045332)2.68738341
87lipid translocation (GO:0034204)2.68738341
88keratinocyte proliferation (GO:0043616)2.67421341
89presynaptic membrane assembly (GO:0097105)2.66725039
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66135547
91vesicle transport along microtubule (GO:0047496)2.65890675
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.65168349
93regulation of synaptic transmission, glutamatergic (GO:0051966)2.63087947
94nerve growth factor signaling pathway (GO:0038180)2.62789903
95regulation of dendritic spine development (GO:0060998)2.62666450
96chemosensory behavior (GO:0007635)2.61871747
97peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.61551560
98gap junction assembly (GO:0016264)2.61114363
99potassium ion homeostasis (GO:0055075)2.60218804
100axon ensheathment in central nervous system (GO:0032291)2.59777945
101central nervous system myelination (GO:0022010)2.59777945
102membrane depolarization during action potential (GO:0086010)2.59299387
103innervation (GO:0060384)2.58977929
104membrane hyperpolarization (GO:0060081)2.57754778
105presynaptic membrane organization (GO:0097090)2.57364232
106regulation of transforming growth factor beta2 production (GO:0032909)2.56888099
107synapse organization (GO:0050808)2.56644270
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55099831
109postsynaptic membrane organization (GO:0001941)2.53385548
110semaphorin-plexin signaling pathway (GO:0071526)2.52763417
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52640899
112mating behavior (GO:0007617)2.52581274
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52504291
114vascular endothelial growth factor signaling pathway (GO:0038084)2.51122005
115regulation of clathrin-mediated endocytosis (GO:2000369)2.50915583
116cell communication involved in cardiac conduction (GO:0086065)2.50762571
117suckling behavior (GO:0001967)2.50187453
118neuromuscular process controlling posture (GO:0050884)2.49433724
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.49393903
120membrane assembly (GO:0071709)2.49120859
121synapse assembly (GO:0007416)2.49020266
122auditory behavior (GO:0031223)2.48943885
123plasma membrane repair (GO:0001778)2.48595942
124positive regulation of dendritic spine development (GO:0060999)2.48530319
125regulation of neurotransmitter levels (GO:0001505)2.48396575
126regulation of vesicle fusion (GO:0031338)2.47295861
127regulation of voltage-gated calcium channel activity (GO:1901385)2.46640323
128organelle transport along microtubule (GO:0072384)2.46537322
129adherens junction assembly (GO:0034333)2.45264752
130neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43795447
131peptide cross-linking (GO:0018149)2.42945454
132negative regulation of dendrite morphogenesis (GO:0050774)2.42570750
133multicellular organismal water homeostasis (GO:0050891)2.42118605
134establishment of endothelial barrier (GO:0061028)2.41768471
135cell-substrate adherens junction assembly (GO:0007045)2.41509624
136focal adhesion assembly (GO:0048041)2.41509624
137lymph vessel development (GO:0001945)2.40545482
138clathrin coat assembly (GO:0048268)2.38230306
139protein localization to endosome (GO:0036010)2.36535013
140Rap protein signal transduction (GO:0032486)2.36441617
141regulation of protein polyubiquitination (GO:1902914)2.36309737
142cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35702346
143renal filtration (GO:0097205)2.32489855
144positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.25805821
145positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.25800973
146regulation of synapse maturation (GO:0090128)2.24956490
147vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23343221
148ventricular cardiac muscle cell action potential (GO:0086005)2.21853899
149endothelial tube morphogenesis (GO:0061154)2.21201320
150morphogenesis of an endothelium (GO:0003159)2.21201320
151Notch signaling involved in heart development (GO:0061314)2.20424036
152cellular response to epinephrine stimulus (GO:0071872)2.19975933
153cell-cell junction assembly (GO:0007043)2.18487696
154endocrine hormone secretion (GO:0060986)2.18149637
155keratinocyte differentiation (GO:0030216)2.18092390
156wound healing, spreading of epidermal cells (GO:0035313)2.15743987
157long-chain fatty acid biosynthetic process (GO:0042759)2.15496334
158negative regulation of protein localization to cell surface (GO:2000009)2.15124052
159labyrinthine layer development (GO:0060711)2.14874248
160hippo signaling (GO:0035329)2.12867697
161macroautophagy (GO:0016236)2.12718345
162cell junction assembly (GO:0034329)2.12477633
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.11761641
164regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.11117256
165regulation of cell communication by electrical coupling (GO:0010649)2.11010030
166substrate-dependent cell migration (GO:0006929)2.10890882
167interleukin-6-mediated signaling pathway (GO:0070102)2.10559406
168peripheral nervous system axon ensheathment (GO:0032292)2.09628526
169myelination in peripheral nervous system (GO:0022011)2.09628526
170protein targeting to plasma membrane (GO:0072661)2.08765045
171nucleus localization (GO:0051647)2.08694057
172cardiac conduction (GO:0061337)2.08508711
173negative regulation of keratinocyte proliferation (GO:0010839)2.07525251
174cardiac muscle cell action potential (GO:0086001)2.07522780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.26507515
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.45983320
3GBX2_23144817_ChIP-Seq_PC3_Human3.09052095
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80071026
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75436250
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58764299
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50431397
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50431397
9DROSHA_22980978_ChIP-Seq_HELA_Human2.44276923
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33941704
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33074868
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29071253
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25449352
14* GATA2_21666600_ChIP-Seq_HMVEC_Human2.22323185
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21196193
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19729444
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.08410070
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05149719
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.01921796
20AR_21572438_ChIP-Seq_LNCaP_Human1.96866480
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.93404421
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.92782076
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.91978730
24REST_21632747_ChIP-Seq_MESCs_Mouse1.90918859
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89456708
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85985605
27SOX9_24532713_ChIP-Seq_HFSC_Mouse1.72080947
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.71123227
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.68274105
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66927291
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65551698
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.64283521
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59963572
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58483418
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58434389
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56843746
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.51918018
38* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51312061
39SMAD4_21799915_ChIP-Seq_A2780_Human1.51150142
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48273621
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47380981
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.46677855
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45213614
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44668714
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43635838
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.42650049
47* TBX20_22080862_ChIP-Seq_HEART_Mouse1.42650049
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39587401
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39495758
50AHR_22903824_ChIP-Seq_MCF-7_Human1.37383383
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35972117
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35791109
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35707878
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35459556
55* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34508315
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34167131
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34167131
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34069209
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33502557
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.33269803
61TAF15_26573619_Chip-Seq_HEK293_Human1.32803147
62TP53_16413492_ChIP-PET_HCT116_Human1.32530860
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.32357479
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.31354984
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30653468
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27207824
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26223870
68ZNF274_21170338_ChIP-Seq_K562_Hela1.25664737
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.23589792
70* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23563173
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23181817
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23084742
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.21723824
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21135533
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20928578
76* STAT3_23295773_ChIP-Seq_U87_Human1.20825897
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20506355
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.19403999
79CJUN_26792858_Chip-Seq_BT549_Human1.18878899
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.18254496
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.18007637
82GATA1_22025678_ChIP-Seq_K562_Human1.17663880
83AR_19668381_ChIP-Seq_PC3_Human1.17401883
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.16383805
85* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15706494
86* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15460830
87AR_25329375_ChIP-Seq_VCAP_Human1.14252603
88* TP63_23658742_ChIP-Seq_EP156T_Human1.14111941
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13448750
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12194037
91KDM2B_26808549_Chip-Seq_K562_Human1.11304934
92RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11113063
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.10928858
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.10921659
95* P300_19829295_ChIP-Seq_ESCs_Human1.10817610
96* CDX2_20551321_ChIP-Seq_CACO-2_Human1.10020220
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09923294
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08773607
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08450008
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08209046
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07967466
102* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07504581
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06692087
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.06645150
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05399109
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.05193728
107* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04719569
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04540768
109* TCF4_23295773_ChIP-Seq_U87_Human1.03759773
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02822364
111RXR_22108803_ChIP-Seq_LS180_Human1.02321860
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01966322
113* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00692335
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00627792
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00159269
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99356331
117SOX2_20726797_ChIP-Seq_SW620_Human0.98191069
118Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.95083850
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94801769
120BCAT_22108803_ChIP-Seq_LS180_Human0.94602598
121* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94362344
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.94271658
123TP53_18474530_ChIP-ChIP_U2OS_Human0.94167326
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92901892
125* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92525305
126KLF5_25053715_ChIP-Seq_YYC3_Human0.91718960
127CLOCK_20551151_ChIP-Seq_293T_Human0.91172611
128* RUNX2_22187159_ChIP-Seq_PCA_Human0.90885097
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90578249
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90350087
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90234532
132* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90137663
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90084108
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.89471734
135* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89336066
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88703580
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.88107662
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87687348
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87687348
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86117321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97607751
2MP0010368_abnormal_lymphatic_system4.85471641
3MP0003880_abnormal_central_pattern4.17180293
4MP0003635_abnormal_synaptic_transmissio3.67626065
5MP0004270_analgesia3.54077148
6MP0002796_impaired_skin_barrier3.08415484
7MP0001879_abnormal_lymphatic_vessel2.95562668
8MP0009745_abnormal_behavioral_response2.90810965
9MP0002063_abnormal_learning/memory/cond2.81614736
10MP0002064_seizures2.79711277
11MP0005275_abnormal_skin_tensile2.76647722
12MP0003705_abnormal_hypodermis_morpholog2.73063816
13MP0009046_muscle_twitch2.70956442
14MP0003566_abnormal_cell_adhesion2.67589354
15MP0002272_abnormal_nervous_system2.56420308
16MP0001486_abnormal_startle_reflex2.46116341
17MP0002572_abnormal_emotion/affect_behav2.32912453
18MP0009780_abnormal_chondrocyte_physiolo2.26998119
19MP0001968_abnormal_touch/_nociception2.24597827
20MP0002734_abnormal_mechanical_nocicepti2.22796680
21MP0003329_amyloid_beta_deposits2.17770067
22MP0003950_abnormal_plasma_membrane2.16511871
23MP0004885_abnormal_endolymph2.12537606
24MP0005423_abnormal_somatic_nervous2.11088347
25MP0001501_abnormal_sleep_pattern2.09967348
26MP0001440_abnormal_grooming_behavior2.07346815
27MP0008569_lethality_at_weaning1.98967069
28MP0000383_abnormal_hair_follicle1.98071190
29MP0000579_abnormal_nail_morphology1.93879946
30MP0005167_abnormal_blood-brain_barrier1.86177928
31MP0010352_gastrointestinal_tract_polyps1.85103478
32MP0002735_abnormal_chemical_nociception1.84079941
33MP0003828_pulmonary_edema1.82847340
34MP0002067_abnormal_sensory_capabilities1.82646048
35MP0000778_abnormal_nervous_system1.80571391
36MP0000920_abnormal_myelination1.75897415
37MP0004145_abnormal_muscle_electrophysio1.74941830
38MP0003091_abnormal_cell_migration1.74360635
39MP0002733_abnormal_thermal_nociception1.70170015
40MP0005023_abnormal_wound_healing1.69918275
41MP0003690_abnormal_glial_cell1.67736878
42MP0004858_abnormal_nervous_system1.67201650
43MP0002736_abnormal_nociception_after1.66545747
44MP0000465_gastrointestinal_hemorrhage1.65836335
45MP0003453_abnormal_keratinocyte_physiol1.63360415
46MP0001970_abnormal_pain_threshold1.60879697
47MP0002909_abnormal_adrenal_gland1.58604230
48MP0004264_abnormal_extraembryonic_tissu1.55441274
49MP0002184_abnormal_innervation1.49898155
50MP0003633_abnormal_nervous_system1.46663868
51MP0004782_abnormal_surfactant_physiolog1.46438533
52MP0000751_myopathy1.45541018
53MP0005501_abnormal_skin_physiology1.41013085
54MP0002098_abnormal_vibrissa_morphology1.40094555
55MP0000955_abnormal_spinal_cord1.38052970
56MP0002822_catalepsy1.37466805
57MP0005623_abnormal_meninges_morphology1.37389306
58MP0001177_atelectasis1.35521266
59MP0003941_abnormal_skin_development1.34897914
60MP0004924_abnormal_behavior1.34688126
61MP0005386_behavior/neurological_phenoty1.34688126
62MP0002557_abnormal_social/conspecific_i1.34260878
63MP0002877_abnormal_melanocyte_morpholog1.34187823
64MP0003631_nervous_system_phenotype1.32370332
65MP0002066_abnormal_motor_capabilities/c1.30891929
66MP0004811_abnormal_neuron_physiology1.28404496
67MP0002882_abnormal_neuron_morphology1.27530587
68MP0004215_abnormal_myocardial_fiber1.26971874
69MP0004484_altered_response_of1.25627058
70MP0002837_dystrophic_cardiac_calcinosis1.25007070
71MP0000013_abnormal_adipose_tissue1.23663784
72MP0003045_fibrosis1.23633215
73MP0003632_abnormal_nervous_system1.21662215
74MP0004742_abnormal_vestibular_system1.21215264
75MP0000377_abnormal_hair_follicle1.19219731
76MP0000733_abnormal_muscle_development1.18381188
77MP0000537_abnormal_urethra_morphology1.18012402
78MP0000767_abnormal_smooth_muscle1.15848392
79MP0003279_aneurysm1.15112432
80MP0005595_abnormal_vascular_smooth1.15099545
81MP0010234_abnormal_vibrissa_follicle1.14482459
82MP0004272_abnormal_basement_membrane1.14436503
83MP0003634_abnormal_glial_cell1.13834097
84MP0003879_abnormal_hair_cell1.12391286
85MP0001851_eye_inflammation1.10675080
86MP0005076_abnormal_cell_differentiation1.09712936
87MP0001216_abnormal_epidermal_layer1.08020449
88MP0002060_abnormal_skin_morphology1.06247519
89MP0004085_abnormal_heartbeat1.05116652
90MP0003191_abnormal_cellular_cholesterol1.04999847
91MP0005645_abnormal_hypothalamus_physiol1.03793523
92MP0010771_integument_phenotype1.03502316
93MP0001348_abnormal_lacrimal_gland1.00995240
94MP0005375_adipose_tissue_phenotype1.00877972
95MP0004130_abnormal_muscle_cell0.99844568
96MP0002229_neurodegeneration0.97780841
97MP0005171_absent_coat_pigmentation0.97270397
98MP0002152_abnormal_brain_morphology0.97051176
99MP0001299_abnormal_eye_distance/0.95434176
100MP0005165_increased_susceptibility_to0.94921410
101MP0004043_abnormal_pH_regulation0.93066673
102MP0004087_abnormal_muscle_fiber0.92956650
103MP0004036_abnormal_muscle_relaxation0.92873210
104MP0001502_abnormal_circadian_rhythm0.92618511
105MP0001485_abnormal_pinna_reflex0.91801742
106MP0008961_abnormal_basal_metabolism0.91653598
107MP0002108_abnormal_muscle_morphology0.91025383
108MP0000762_abnormal_tongue_morphology0.89951780
109MP0000604_amyloidosis0.89579509
110MP0005409_darkened_coat_color0.89508037
111MP0005666_abnormal_adipose_tissue0.89048663
112MP0008438_abnormal_cutaneous_collagen0.88226979
113MP0010630_abnormal_cardiac_muscle0.86649781
114MP0008874_decreased_physiological_sensi0.85967136
115MP0000749_muscle_degeneration0.85759428
116MP0003300_gastrointestinal_ulcer0.84863606
117MP0004233_abnormal_muscle_weight0.84589641
118MP0004510_myositis0.84399403
119MP0004084_abnormal_cardiac_muscle0.83641409
120MP0005670_abnormal_white_adipose0.83119289
121MP0004142_abnormal_muscle_tone0.82647426
122MP0003787_abnormal_imprinting0.82434058
123MP0000467_abnormal_esophagus_morphology0.81991922
124MP0000003_abnormal_adipose_tissue0.81812923
125MP0002009_preneoplasia0.81364394
126MP0005551_abnormal_eye_electrophysiolog0.81297357
127MP0000747_muscle_weakness0.81164816
128MP0002925_abnormal_cardiovascular_devel0.80759718
129MP0000427_abnormal_hair_cycle0.79412097
130MP0002168_other_aberrant_phenotype0.79306630
131MP0006276_abnormal_autonomic_nervous0.79213392
132MP0002332_abnormal_exercise_endurance0.79002697
133MP0006138_congestive_heart_failure0.78662946
134MP0005187_abnormal_penis_morphology0.77671884
135MP0001784_abnormal_fluid_regulation0.77507090
136MP0004947_skin_inflammation0.77323324
137MP0003868_abnormal_feces_composition0.77304602
138MP0005535_abnormal_body_temperature0.76618673
139MP0000569_abnormal_digit_pigmentation0.76590656
140MP0000759_abnormal_skeletal_muscle0.76047699
141MP0004185_abnormal_adipocyte_glucose0.75858181
142MP0002069_abnormal_eating/drinking_beha0.75837828
143MP0003137_abnormal_impulse_conducting0.75346517
144MP0002295_abnormal_pulmonary_circulatio0.74657802
145MP0005620_abnormal_muscle_contractility0.74140559
146MP0001905_abnormal_dopamine_level0.73789467
147MP0003075_altered_response_to0.73027110
148MP0005388_respiratory_system_phenotype0.72968274
149MP0002133_abnormal_respiratory_system0.72968274
150MP0003283_abnormal_digestive_organ0.72456514
151MP0005646_abnormal_pituitary_gland0.71232989
152MP0001963_abnormal_hearing_physiology0.70955403
153MP0001188_hyperpigmentation0.69779771
154MP0004147_increased_porphyrin_level0.68319121
155MP0002234_abnormal_pharynx_morphology0.65978605
156MP0001958_emphysema0.63729660
157MP0010678_abnormal_skin_adnexa0.62656944
158MP0001984_abnormal_olfaction0.62650089

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.92170287
2Myokymia (HP:0002411)4.97397295
3Action tremor (HP:0002345)4.75516556
4Focal seizures (HP:0007359)4.68761544
5Visual hallucinations (HP:0002367)4.14742612
6Right ventricular cardiomyopathy (HP:0011663)3.88030316
7Atonic seizures (HP:0010819)3.87998326
8Progressive cerebellar ataxia (HP:0002073)3.64674238
9Supranuclear gaze palsy (HP:0000605)3.57672780
10Neurofibrillary tangles (HP:0002185)3.47665513
11Intention tremor (HP:0002080)3.38813570
12Epileptic encephalopathy (HP:0200134)3.38617501
13Dysmetria (HP:0001310)3.35713432
14Broad-based gait (HP:0002136)3.31843353
15Cerebral inclusion bodies (HP:0100314)3.30050820
16Scanning speech (HP:0002168)3.24888153
17Hyporeflexia of lower limbs (HP:0002600)3.11563634
18Febrile seizures (HP:0002373)3.10811462
19Insidious onset (HP:0003587)3.09569271
20Termporal pattern (HP:0011008)3.09569271
21Dysdiadochokinesis (HP:0002075)3.08772360
22Absence seizures (HP:0002121)3.02363867
23Gaze-evoked nystagmus (HP:0000640)2.95856413
24Abnormality of the corticospinal tract (HP:0002492)2.92945633
25Arterial tortuosity (HP:0005116)2.86151469
26Thick nail (HP:0001805)2.85977682
27Hemiplegia (HP:0002301)2.84774169
28Overgrowth (HP:0001548)2.82032601
29Dialeptic seizures (HP:0011146)2.77167042
30Generalized tonic-clonic seizures (HP:0002069)2.76023492
31Poor eye contact (HP:0000817)2.73758189
32Impaired social interactions (HP:0000735)2.68267375
33Abnormal social behavior (HP:0012433)2.68267375
34Postural instability (HP:0002172)2.66368034
35Hemiparesis (HP:0001269)2.63476459
36Subacute progressive viral hepatitis (HP:0006572)2.59679825
37Truncal ataxia (HP:0002078)2.57845384
38Ankle clonus (HP:0011448)2.57158245
39Vascular tortuosity (HP:0004948)2.56756334
40Hyperventilation (HP:0002883)2.54085927
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52325442
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.52325442
43Onion bulb formation (HP:0003383)2.50369780
44Diplopia (HP:0000651)2.49891076
45Abnormality of binocular vision (HP:0011514)2.49891076
46Impaired vibration sensation in the lower limbs (HP:0002166)2.49397947
47Depression (HP:0000716)2.48006841
48Ventricular fibrillation (HP:0001663)2.46172038
49Cerebral aneurysm (HP:0004944)2.41194131
50Abnormal eating behavior (HP:0100738)2.39999397
51Excessive salivation (HP:0003781)2.39166938
52Drooling (HP:0002307)2.39166938
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.38302281
54Osteolytic defects of the hand bones (HP:0009699)2.38302281
55Genetic anticipation (HP:0003743)2.37884558
56Milia (HP:0001056)2.35776877
57Spastic gait (HP:0002064)2.35668822
58Anxiety (HP:0000739)2.34480253
59Aplasia involving bones of the upper limbs (HP:0009823)2.33769847
60Aplasia of the phalanges of the hand (HP:0009802)2.33769847
61Aplasia involving bones of the extremities (HP:0009825)2.33769847
62Urinary bladder sphincter dysfunction (HP:0002839)2.32625907
63Mutism (HP:0002300)2.30363663
64Amblyopia (HP:0000646)2.29851208
65Increased circulating renin level (HP:0000848)2.29831855
66Atrophic scars (HP:0001075)2.29807001
67Interstitial pulmonary disease (HP:0006530)2.29144508
68Atrioventricular block (HP:0001678)2.27640387
69Advanced eruption of teeth (HP:0006288)2.27044190
70Aortic aneurysm (HP:0004942)2.27037134
71Aqueductal stenosis (HP:0002410)2.24397624
72Peripheral hypomyelination (HP:0007182)2.23452431
73Difficulty running (HP:0009046)2.23270581
74Onycholysis (HP:0001806)2.23255873
75Abnormality of nail color (HP:0100643)2.19209130
76Alopecia of scalp (HP:0002293)2.19118222
77Urinary urgency (HP:0000012)2.17518344
78Plantar hyperkeratosis (HP:0007556)2.16900523
79Impaired smooth pursuit (HP:0007772)2.15207813
80Lower limb muscle weakness (HP:0007340)2.14680232
81Abnormality of the lower motor neuron (HP:0002366)2.14497932
82Increased connective tissue (HP:0009025)2.13656619
83Lower limb amyotrophy (HP:0007210)2.13216143
84Distal lower limb amyotrophy (HP:0008944)2.11694918
85Dysmetric saccades (HP:0000641)2.11143113
86Broad metatarsal (HP:0001783)2.10912963
87Hypoplasia of the iris (HP:0007676)2.08708309
88Hypotrichosis (HP:0001006)2.07846190
89Abnormal atrioventricular conduction (HP:0005150)2.07250089
90Ventricular tachycardia (HP:0004756)2.06361632
91Hyperkalemia (HP:0002153)2.06294796
92Stereotypic behavior (HP:0000733)2.06052381
93Broad face (HP:0000283)2.05763477
94Protrusio acetabuli (HP:0003179)2.04412284
95Short chin (HP:0000331)2.04393325
96Palmoplantar hyperkeratosis (HP:0000972)2.02239795
97Bundle branch block (HP:0011710)2.01495346
98Megalencephaly (HP:0001355)1.99297392
99Absent speech (HP:0001344)1.98621188
100Progressive inability to walk (HP:0002505)1.98143534
101Muscle fiber splitting (HP:0003555)1.97926747
102Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97594431
103Ankyloglossia (HP:0010296)1.96835759
104Heart block (HP:0012722)1.95586639
105Acanthosis nigricans (HP:0000956)1.94898306
106Fetal akinesia sequence (HP:0001989)1.94679035
107Abnormality of secondary sexual hair (HP:0009888)1.91400987
108Abnormality of the axillary hair (HP:0100134)1.91400987
109Bronchomalacia (HP:0002780)1.91269212
110Palmar hyperkeratosis (HP:0010765)1.91071404
111Gait ataxia (HP:0002066)1.89824242
112Postural tremor (HP:0002174)1.88893207
113Absent hand (HP:0004050)1.88862258
114Shallow orbits (HP:0000586)1.88577592
115Reduced subcutaneous adipose tissue (HP:0003758)1.88384313
116Hammertoe (HP:0001765)1.88031648
117Visceral angiomatosis (HP:0100761)1.87450209
118Esophageal varix (HP:0002040)1.87114139
119Prolonged QT interval (HP:0001657)1.86930137
120Thyroid-stimulating hormone excess (HP:0002925)1.86549921
121Rapidly progressive (HP:0003678)1.86111151
122Abnormality of ocular smooth pursuit (HP:0000617)1.86006149
123Torticollis (HP:0000473)1.85642082
124Absent eyelashes (HP:0000561)1.85596815
125Abnormality of the fingertips (HP:0001211)1.85196040
126Epileptiform EEG discharges (HP:0011182)1.84872321
127Sudden death (HP:0001699)1.84172474
128Lower limb asymmetry (HP:0100559)1.84083211
129Spontaneous hematomas (HP:0007420)1.83928396
130Syncope (HP:0001279)1.83843181
131Hypoplastic nipples (HP:0002557)1.83036293
132Incomplete penetrance (HP:0003829)1.82874866
133Abnormality of the salivary glands (HP:0010286)1.81225093
134Lip pit (HP:0100267)1.79826118
135Bradykinesia (HP:0002067)1.78409162
136Annular pancreas (HP:0001734)1.77467508
137Laryngomalacia (HP:0001601)1.75403953
138Hemangiomatosis (HP:0007461)1.74818555
139Pheochromocytoma (HP:0002666)1.74648144
140Cerebral hemorrhage (HP:0001342)1.74572506
141Distal lower limb muscle weakness (HP:0009053)1.74289128
142Clonus (HP:0002169)1.72616249
143EEG with generalized epileptiform discharges (HP:0011198)1.72262359
144Striae distensae (HP:0001065)1.71919151
145Buphthalmos (HP:0000557)1.71864811
146Germ cell neoplasia (HP:0100728)1.71591236
147Split foot (HP:0001839)1.71453127
148Obstructive sleep apnea (HP:0002870)1.70891981
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.70444102
150Alacrima (HP:0000522)1.70191232
151Abnormality of salivation (HP:0100755)1.69417049
152Neuronal loss in central nervous system (HP:0002529)1.69362351
153Metabolic alkalosis (HP:0200114)1.68882124
154Fragile nails (HP:0001808)1.68627209
155Atrial fibrillation (HP:0005110)1.67107076
156Oligodactyly (hands) (HP:0001180)1.66526071
157Papilledema (HP:0001085)1.66429676
158Abnormality of saccadic eye movements (HP:0000570)1.66257724
159Short nail (HP:0001799)1.66180006
160Glucose intolerance (HP:0000833)1.66115809
161Status epilepticus (HP:0002133)1.66057351
162Growth hormone excess (HP:0000845)1.65745052
163Bradycardia (HP:0001662)1.65418015
164Mitral valve prolapse (HP:0001634)1.65209840
165Aneurysm (HP:0002617)1.64613744
166Abnormality of oral frenula (HP:0000190)1.64552633
167Hypoplasia of dental enamel (HP:0006297)1.64089301
168Decreased motor nerve conduction velocity (HP:0003431)1.63744232
169Limited hip movement (HP:0008800)1.63229079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.77562094
2EPHA43.41346411
3MST1R3.38010107
4LATS12.93299812
5MAP3K92.87181004
6MET2.58154668
7EPHA22.24255760
8MARK12.19775603
9MAP3K42.17268821
10PAK62.08396801
11MINK11.99477613
12DAPK21.97587069
13STK391.94152208
14NTRK11.92269753
15KSR21.91823961
16PRKD31.91355903
17TYRO31.89552208
18TNIK1.87472455
19TRPM71.80570527
20NTRK21.66334680
21OXSR11.65811627
22FGFR21.62266630
23TTN1.57010026
24AKT31.53443188
25RIPK41.47835214
26RIPK11.44440658
27MAP2K41.42942955
28PHKG11.40526725
29PHKG21.40526725
30CAMKK11.39808854
31TIE11.39302492
32PNCK1.37676464
33TGFBR21.37476326
34CDK51.37433955
35MAP3K21.36172053
36CASK1.31496002
37CAMK1G1.31454514
38STK381.31321563
39STK38L1.30609285
40CDK121.30582483
41PTK2B1.30015037
42EPHB11.29996906
43PRPF4B1.28730075
44MAPK131.27989047
45EEF2K1.27403195
46WNK11.27367387
47FES1.21671344
48KDR1.19382149
49MAP2K71.17872194
50DMPK1.11708128
51RET1.08119549
52MARK21.07285449
53TRIB31.07134139
54LMTK21.06370722
55PAK31.06201174
56SGK2231.05516705
57SGK4941.05516705
58CAMK2B1.05261346
59CAMKK21.02287192
60FGFR30.99441977
61CAMK2A0.99392127
62FER0.99021675
63WNK40.98872571
64PINK10.98626923
65PKN10.98396718
66GRK50.97055288
67JAK10.95089505
68MAP3K130.94995222
69KSR10.94546449
70PRKCH0.94501252
71FGFR40.93975058
72UHMK10.93695855
73STK110.92849302
74MAP3K70.92323963
75MAPK70.87726519
76CAMK10.87411470
77PLK20.87229517
78EPHB20.85899003
79MAP3K120.84135639
80PRKCG0.83978624
81SIK20.83505917
82ROCK20.82656959
83PDPK10.82440116
84SGK10.80064084
85PDGFRA0.76984715
86DAPK10.76888952
87CAMK2D0.73865257
88PDK10.73858987
89FGR0.71634366
90MTOR0.70981406
91TGFBR10.70303480
92STK240.69567093
93PRKCE0.68648775
94CAMK1D0.68270570
95INSRR0.66293220
96MAP3K60.65699724
97LATS20.65252331
98CDC42BPA0.64319078
99PDGFRB0.64103295
100MAPKAPK50.63297868
101MELK0.63112158
102PTK20.61928888
103SGK30.61506651
104NEK60.61208071
105CSNK1G20.60843498
106SGK20.60234570
107ALK0.60104551
108BCR0.59444272
109PRKD10.58591666
110FYN0.58476713
111ICK0.58098002
112NLK0.57322677
113DYRK1A0.54174879
114CAMK40.53759555
115MAP3K10.51771385
116RPS6KA30.51645401
117ITK0.51604095
118CAMK2G0.50920142
119CSK0.50016854
120CDK140.49038811
121DDR20.48419208
122PRKAA20.48040791
123ROCK10.47583174
124MYLK0.47086286
125MAPK100.46584563
126CDK150.46233442
127MAPK120.45976676
128BMX0.45826334
129PTK60.45617256
130WNK30.44437802
131RPS6KA20.43886727
132BMPR20.43245391
133MAP2K10.42778946
134EPHA30.42081191
135MAP3K30.39469254
136OBSCN0.38729876
137FGFR10.38531496
138ZAP700.38073598

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.92292116
2Glutamatergic synapse_Homo sapiens_hsa047242.46335635
3Long-term potentiation_Homo sapiens_hsa047202.41440303
4Circadian entrainment_Homo sapiens_hsa047132.34173920
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30363792
6Salivary secretion_Homo sapiens_hsa049702.18773947
7GABAergic synapse_Homo sapiens_hsa047272.18696530
8Synaptic vesicle cycle_Homo sapiens_hsa047212.06133148
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02203078
10Adherens junction_Homo sapiens_hsa045202.00435381
11Morphine addiction_Homo sapiens_hsa050321.95794888
12Amphetamine addiction_Homo sapiens_hsa050311.94575362
13Gastric acid secretion_Homo sapiens_hsa049711.93329389
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81331057
15Long-term depression_Homo sapiens_hsa047301.81196406
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75872126
17Olfactory transduction_Homo sapiens_hsa047401.74708430
18Dopaminergic synapse_Homo sapiens_hsa047281.72109615
19Renin secretion_Homo sapiens_hsa049241.69861104
20Cholinergic synapse_Homo sapiens_hsa047251.68936548
21Insulin secretion_Homo sapiens_hsa049111.68000565
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58944733
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56855358
24Taste transduction_Homo sapiens_hsa047421.56165160
25Nitrogen metabolism_Homo sapiens_hsa009101.49244452
26Axon guidance_Homo sapiens_hsa043601.46834717
27Calcium signaling pathway_Homo sapiens_hsa040201.43405004
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42831176
29GnRH signaling pathway_Homo sapiens_hsa049121.38890421
30Serotonergic synapse_Homo sapiens_hsa047261.38882319
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30332095
32Gap junction_Homo sapiens_hsa045401.28208921
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27707725
34Type II diabetes mellitus_Homo sapiens_hsa049301.27655937
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.26063342
36cAMP signaling pathway_Homo sapiens_hsa040241.25928466
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19910270
38Estrogen signaling pathway_Homo sapiens_hsa049151.18389007
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17629252
40Cocaine addiction_Homo sapiens_hsa050301.14488971
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14239135
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.11637648
43Pancreatic secretion_Homo sapiens_hsa049721.10870061
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10701190
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.08770652
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08674081
47Thyroid cancer_Homo sapiens_hsa052161.07632746
48Glioma_Homo sapiens_hsa052141.05537210
49Dorso-ventral axis formation_Homo sapiens_hsa043201.04512402
50Dilated cardiomyopathy_Homo sapiens_hsa054141.00353514
51Small cell lung cancer_Homo sapiens_hsa052220.98591541
52Choline metabolism in cancer_Homo sapiens_hsa052310.98079336
53Melanogenesis_Homo sapiens_hsa049160.95941649
54Thyroid hormone synthesis_Homo sapiens_hsa049180.95084191
55Chronic myeloid leukemia_Homo sapiens_hsa052200.92198296
56Pancreatic cancer_Homo sapiens_hsa052120.90401632
57ErbB signaling pathway_Homo sapiens_hsa040120.89802341
58Histidine metabolism_Homo sapiens_hsa003400.87635557
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86173683
60Collecting duct acid secretion_Homo sapiens_hsa049660.84637247
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82746365
62VEGF signaling pathway_Homo sapiens_hsa043700.81541425
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79764112
64Non-small cell lung cancer_Homo sapiens_hsa052230.79561325
65Hippo signaling pathway_Homo sapiens_hsa043900.79312612
66Bile secretion_Homo sapiens_hsa049760.75681172
67Prion diseases_Homo sapiens_hsa050200.75524868
68Renal cell carcinoma_Homo sapiens_hsa052110.73972177
69Rap1 signaling pathway_Homo sapiens_hsa040150.73699419
70Fatty acid biosynthesis_Homo sapiens_hsa000610.72595402
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71895595
72Ras signaling pathway_Homo sapiens_hsa040140.71673294
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70827245
74Cardiac muscle contraction_Homo sapiens_hsa042600.70521686
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70201066
76MicroRNAs in cancer_Homo sapiens_hsa052060.69767821
77MAPK signaling pathway_Homo sapiens_hsa040100.69279726
78Pathways in cancer_Homo sapiens_hsa052000.69213316
79Tight junction_Homo sapiens_hsa045300.69110533
80HIF-1 signaling pathway_Homo sapiens_hsa040660.68924046
81FoxO signaling pathway_Homo sapiens_hsa040680.67199456
82Insulin resistance_Homo sapiens_hsa049310.66607612
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.66449460
84ABC transporters_Homo sapiens_hsa020100.66092087
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65890456
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65762907
87Ovarian steroidogenesis_Homo sapiens_hsa049130.65009030
88Notch signaling pathway_Homo sapiens_hsa043300.64586348
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63862841
90Inositol phosphate metabolism_Homo sapiens_hsa005620.63648590
91Vibrio cholerae infection_Homo sapiens_hsa051100.62552778
92Prolactin signaling pathway_Homo sapiens_hsa049170.58578783
93Focal adhesion_Homo sapiens_hsa045100.58459656
94Glucagon signaling pathway_Homo sapiens_hsa049220.57566167
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57033340
96Endocytosis_Homo sapiens_hsa041440.56936968
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55639141
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52871071
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52645877
100Platelet activation_Homo sapiens_hsa046110.51874970
101mTOR signaling pathway_Homo sapiens_hsa041500.50614656
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49974071
103Oocyte meiosis_Homo sapiens_hsa041140.48409239
104ECM-receptor interaction_Homo sapiens_hsa045120.48130835
105Mineral absorption_Homo sapiens_hsa049780.48095813
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.47838214
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44200082
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43198640
109Wnt signaling pathway_Homo sapiens_hsa043100.42512691
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.42009446
111Amoebiasis_Homo sapiens_hsa051460.40826716
112African trypanosomiasis_Homo sapiens_hsa051430.39790088
113Endometrial cancer_Homo sapiens_hsa052130.39152416
114Phototransduction_Homo sapiens_hsa047440.38512845
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37688180
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.37065098
117AMPK signaling pathway_Homo sapiens_hsa041520.36670581
118Ether lipid metabolism_Homo sapiens_hsa005650.36354423
119Proteoglycans in cancer_Homo sapiens_hsa052050.35608022
120Insulin signaling pathway_Homo sapiens_hsa049100.34877861
121Circadian rhythm_Homo sapiens_hsa047100.33082315

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