DOHH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.44567013
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.10810084
3formation of translation preinitiation complex (GO:0001731)5.04947183
4nucleobase biosynthetic process (GO:0046112)4.43908667
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.40696410
6maturation of SSU-rRNA (GO:0030490)4.28922274
7folic acid-containing compound biosynthetic process (GO:0009396)4.17194983
8ribosome biogenesis (GO:0042254)4.15139776
9DNA strand elongation involved in DNA replication (GO:0006271)4.14473818
10protein retention in ER lumen (GO:0006621)4.14169221
11purine nucleobase biosynthetic process (GO:0009113)4.14115623
12DNA unwinding involved in DNA replication (GO:0006268)4.07251365
13regulation of mammary gland epithelial cell proliferation (GO:0033599)4.03139680
14mitotic nuclear envelope reassembly (GO:0007084)4.01389823
15nuclear envelope reassembly (GO:0031468)4.01389823
16proline metabolic process (GO:0006560)3.94362037
17DNA strand elongation (GO:0022616)3.88658713
18viral transcription (GO:0019083)3.88556630
19UV protection (GO:0009650)3.84650333
20DNA replication initiation (GO:0006270)3.83701541
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.82109934
22translational elongation (GO:0006414)3.81439927
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.80826360
24ribonucleoprotein complex biogenesis (GO:0022613)3.80230757
25translational termination (GO:0006415)3.80154744
26DNA replication-dependent nucleosome organization (GO:0034723)3.79548373
27DNA replication-dependent nucleosome assembly (GO:0006335)3.79548373
28ribosomal small subunit assembly (GO:0000028)3.78671359
29proteasome assembly (GO:0043248)3.76704941
30adenosine receptor signaling pathway (GO:0001973)3.75034807
31ribosome assembly (GO:0042255)3.74024104
32ribosomal large subunit biogenesis (GO:0042273)3.73988084
33telomere maintenance via semi-conservative replication (GO:0032201)3.73714696
34translational initiation (GO:0006413)3.72298194
35pseudouridine synthesis (GO:0001522)3.67711568
36spliceosomal snRNP assembly (GO:0000387)3.66833045
37folic acid metabolic process (GO:0046655)3.63498347
38regulation of translational termination (GO:0006449)3.57997859
39GMP metabolic process (GO:0046037)3.57556197
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.54228225
41IMP biosynthetic process (GO:0006188)3.52215798
42histone arginine methylation (GO:0034969)3.49401542
43peptidyl-arginine omega-N-methylation (GO:0035247)3.46485877
44DNA replication checkpoint (GO:0000076)3.44029823
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43811313
46chaperone mediated protein folding requiring cofactor (GO:0051085)3.41485914
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40960693
48rRNA processing (GO:0006364)3.39740190
49ribosomal small subunit biogenesis (GO:0042274)3.39613513
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37957648
51pteridine-containing compound biosynthetic process (GO:0042559)3.35015890
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33807228
53COPI coating of Golgi vesicle (GO:0048205)3.32035808
54Golgi transport vesicle coating (GO:0048200)3.32035808
55protein targeting to ER (GO:0045047)3.30531586
56mitochondrial fusion (GO:0008053)3.30440215
57cotranslational protein targeting to membrane (GO:0006613)3.30054621
58negative regulation of ligase activity (GO:0051352)3.29802089
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29802089
60positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.29216143
61nucleobase-containing small molecule interconversion (GO:0015949)3.29021649
62activation of MAPKKK activity (GO:0000185)3.27755801
63protein insertion into membrane (GO:0051205)3.27272242
64rRNA metabolic process (GO:0016072)3.27044068
65GDP-mannose metabolic process (GO:0019673)3.26190055
66translation (GO:0006412)3.24477122
67nucleotide salvage (GO:0043173)3.23813069
68protein complex localization (GO:0031503)3.23522916
69iron-sulfur cluster assembly (GO:0016226)3.22399754
70metallo-sulfur cluster assembly (GO:0031163)3.22399754
71mitotic nuclear envelope disassembly (GO:0007077)3.21964927
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19865828
73protein localization to kinetochore (GO:0034501)3.18385448
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16077156
75viral life cycle (GO:0019058)3.15689648
76deoxyribose phosphate biosynthetic process (GO:0046385)3.15479296
772-deoxyribonucleotide biosynthetic process (GO:0009265)3.15479296
78protein localization to endoplasmic reticulum (GO:0070972)3.13556213
79positive regulation of protein sumoylation (GO:0033235)3.12544582
80positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12490381
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12391440
82establishment of integrated proviral latency (GO:0075713)3.12038872
83cellular protein complex disassembly (GO:0043624)3.11800479
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11713751
85negative regulation of B cell apoptotic process (GO:0002903)3.10731161
86pentose-phosphate shunt (GO:0006098)3.08356287
87modulation by virus of host process (GO:0019054)3.07633738
88tRNA aminoacylation for protein translation (GO:0006418)3.06709594
89base-excision repair, AP site formation (GO:0006285)3.05611157
90regulation of mitochondrial translation (GO:0070129)3.05237964
91IMP metabolic process (GO:0046040)3.05132532
92regulation of translational fidelity (GO:0006450)3.05056100
93peptidyl-arginine N-methylation (GO:0035246)3.04923118
94peptidyl-arginine methylation (GO:0018216)3.04923118
95modulation by symbiont of host cellular process (GO:0044068)3.04329293
96regulation of posttranscriptional gene silencing (GO:0060147)3.03762063
97regulation of gene silencing by miRNA (GO:0060964)3.03762063
98regulation of gene silencing by RNA (GO:0060966)3.03762063
99viral mRNA export from host cell nucleus (GO:0046784)3.03534080
100proline biosynthetic process (GO:0006561)3.03070558
101pentose metabolic process (GO:0019321)3.02989816
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02433914
103mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.02399670
104rRNA modification (GO:0000154)3.01970964
105de novo protein folding (GO:0006458)3.01553141
106amino acid activation (GO:0043038)3.01452192
107tRNA aminoacylation (GO:0043039)3.01452192
108transcription elongation from RNA polymerase III promoter (GO:0006385)3.00906769
109termination of RNA polymerase III transcription (GO:0006386)3.00906769
110nuclear envelope disassembly (GO:0051081)3.00307428
111membrane disassembly (GO:0030397)3.00307428
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.99633470
113telomere maintenance via recombination (GO:0000722)2.99543319
114cellular component biogenesis (GO:0044085)2.98735919
115cullin deneddylation (GO:0010388)2.97990573
116positive regulation of ligase activity (GO:0051351)2.97209152
117protein maturation by protein folding (GO:0022417)2.96770480
118protein complex disassembly (GO:0043241)2.96655395
119negative regulation of erythrocyte differentiation (GO:0045647)2.96366559
120protein localization to endosome (GO:0036010)2.95589967
121negative regulation of cell size (GO:0045792)2.95003918
122pyrimidine nucleoside salvage (GO:0043097)2.94440240
123pyrimidine-containing compound salvage (GO:0008655)2.94440240
124transcription-coupled nucleotide-excision repair (GO:0006283)2.92673502
125retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91862070
126negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.90529858
127regulation of cellular amino acid metabolic process (GO:0006521)2.90301724
128telomere maintenance via telomere lengthening (GO:0010833)2.89258424
129protein deneddylation (GO:0000338)2.89075044
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88996503
131glucose catabolic process (GO:0006007)2.88348851
132mitotic metaphase plate congression (GO:0007080)2.87235035
133regulation of skeletal muscle contraction (GO:0014819)2.86977001
134macromolecular complex disassembly (GO:0032984)2.86841787
135regulation of ubiquitin-protein transferase activity (GO:0051438)2.85364938
136establishment of protein localization to mitochondrion (GO:0072655)2.85172898
137signal transduction involved in DNA damage checkpoint (GO:0072422)2.84782834
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84782834
139regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.84681131
140NIK/NF-kappaB signaling (GO:0038061)2.84507522
141regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84447361
142oxidative phosphorylation (GO:0006119)2.83839905
143endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.83301906
144intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82902816
145signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82902816
146signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82839185
147positive regulation of synapse maturation (GO:0090129)2.78902638
148negative regulation of cell aging (GO:0090344)2.78506379
149mitochondrial calcium ion transport (GO:0006851)2.78133207
150regulation of synapse structural plasticity (GO:0051823)2.77220778
151type B pancreatic cell proliferation (GO:0044342)2.73805854
152semaphorin-plexin signaling pathway (GO:0071526)2.72609683
1533-UTR-mediated mRNA stabilization (GO:0070935)2.70422648
154pinocytosis (GO:0006907)2.70265719
155regulation of cytokine production involved in inflammatory response (GO:1900015)2.65782369
156peptidyl-glutamic acid carboxylation (GO:0017187)2.64458834
157protein carboxylation (GO:0018214)2.64458834
158purine deoxyribonucleotide catabolic process (GO:0009155)2.63270235
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.62312248
160deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.61847427
161lipopolysaccharide biosynthetic process (GO:0009103)2.61024040
162regulation of mitochondrial membrane potential (GO:0051881)2.59232596
163negative regulation of DNA-templated transcription, elongation (GO:0032785)2.55143148
164barbed-end actin filament capping (GO:0051016)2.53201268
165positive regulation of mitochondrion organization (GO:0010822)2.52325218
166nucleoside diphosphate biosynthetic process (GO:0009133)2.51388040
167cytoplasmic sequestering of transcription factor (GO:0042994)2.50536893
168mature B cell differentiation involved in immune response (GO:0002313)2.50216311
169apoptotic process involved in morphogenesis (GO:0060561)2.49519774
170deoxyribonucleotide catabolic process (GO:0009264)2.49004828
171NADPH regeneration (GO:0006740)2.47716499
172regulation of protein sumoylation (GO:0033233)2.47714094
173negative regulation of necrotic cell death (GO:0060547)2.47344437
174cell migration in hindbrain (GO:0021535)2.46556235
175misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.43883240
176negative regulation of necroptotic process (GO:0060546)2.43850575
177prostanoid biosynthetic process (GO:0046457)2.43184897
178prostaglandin biosynthetic process (GO:0001516)2.43184897
179pyrimidine nucleotide catabolic process (GO:0006244)2.40619200
180cellular response to arsenic-containing substance (GO:0071243)2.39123395
181monosaccharide biosynthetic process (GO:0046364)2.39052253
182positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.38381012
183post-embryonic morphogenesis (GO:0009886)2.37893805
184virion assembly (GO:0019068)2.37823389
1852-deoxyribonucleotide metabolic process (GO:0009394)2.36137282
186regulation of cholesterol biosynthetic process (GO:0045540)2.36070342
187intracellular estrogen receptor signaling pathway (GO:0030520)2.34251200
188regulation of mitochondrion organization (GO:0010821)2.33879213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.45253464
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.18600210
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01531762
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14988203
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.00358047
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95300188
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93298211
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.70824841
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65499769
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64998456
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.64936029
12LXR_22292898_ChIP-Seq_THP-1_Human2.64449525
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.61721942
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.58015492
15XRN2_22483619_ChIP-Seq_HELA_Human2.46500454
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46212044
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43352694
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18645688
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13752541
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09236416
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08084716
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07128415
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05917804
24DCP1A_22483619_ChIP-Seq_HELA_Human2.00924905
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97129064
26* GABP_19822575_ChIP-Seq_HepG2_Human1.97115593
27* VDR_23849224_ChIP-Seq_CD4+_Human1.93067433
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89670471
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88126001
30* YY1_21170310_ChIP-Seq_MESCs_Mouse1.82081674
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80879365
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80465435
33RACK7_27058665_Chip-Seq_MCF-7_Human1.79860963
34CIITA_25753668_ChIP-Seq_RAJI_Human1.79170366
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77840403
36MYC_22102868_ChIP-Seq_BL_Human1.77288933
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76856185
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74178873
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72807791
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71815294
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70378487
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.69143271
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68935577
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65940028
45TTF2_22483619_ChIP-Seq_HELA_Human1.65915694
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65324372
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64763053
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62121326
49* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60913301
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60005874
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59231689
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58786049
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58631372
54* KDM2B_26808549_Chip-Seq_DND41_Human1.58099382
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58092814
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.56669354
57MAF_26560356_Chip-Seq_TH2_Human1.55523084
58* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55350037
59BCL6_27268052_Chip-Seq_Bcells_Human1.53033886
60* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52760047
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51977608
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51676327
63BCOR_27268052_Chip-Seq_Bcells_Human1.47920013
64ERG_21242973_ChIP-ChIP_JURKAT_Human1.47769182
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47638287
66KDM5A_27292631_Chip-Seq_BREAST_Human1.40422431
67VDR_21846776_ChIP-Seq_THP-1_Human1.39776204
68MAF_26560356_Chip-Seq_TH1_Human1.39172849
69VDR_24763502_ChIP-Seq_THP-1_Human1.37786552
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36055136
71* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35777982
72SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.33743193
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33005330
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32743615
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31960193
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.31705784
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31242257
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31177078
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.30933209
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.30578141
81* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30188367
82SMC4_20622854_ChIP-Seq_HELA_Human1.29830687
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28562342
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28447455
85TP53_22127205_ChIP-Seq_IMR90_Human1.28360096
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27366904
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26396436
88* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26059989
89UTX_26944678_Chip-Seq_JUKART_Human1.25957878
90E2F1_20622854_ChIP-Seq_HELA_Human1.25355549
91TFEB_21752829_ChIP-Seq_HELA_Human1.24532318
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24242122
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23845748
94* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22978474
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.21697345
96TP63_17297297_ChIP-ChIP_HaCaT_Human1.21527517
97* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21320211
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.21280471
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20565203
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20476362
101CTCF_21964334_Chip-Seq_Bcells_Human1.20171020
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.20162155
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18628435
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18442545
105* YY1_22570637_ChIP-Seq_MALME-3M_Human1.17987303
106CTCF_27219007_Chip-Seq_Bcells_Human1.16850030
107CREB1_26743006_Chip-Seq_LNCaP_Human1.16348760
108ZNF263_19887448_ChIP-Seq_K562_Human1.16343680
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15552322
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15293993
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15167971
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15046574
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14878312
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14488968
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14462988
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14013909
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13881012
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13784953
119CTCF_20526341_ChIP-Seq_ESCs_Human1.12989489
120AR_21909140_ChIP-Seq_LNCAP_Human1.12980868
121ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12875113
122KDM2B_26808549_Chip-Seq_K562_Human1.12226318
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11722078
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11132278
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10441956
126FOXP1_21924763_ChIP-Seq_HESCs_Human1.10047400
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08661922
128CTCF_21964334_ChIP-Seq_BJAB-B_Human1.07843821
129TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07595347
130NCOR1_26117541_ChIP-Seq_K562_Human1.06853388
131RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04499244
132SOX2_18692474_ChIP-Seq_MEFs_Mouse1.04445445
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03312215
134CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02941286
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.02314472
136SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02155150
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01740931
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98937933
139EGR1_19374776_ChIP-ChIP_THP-1_Human0.98852502
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97828629
141* P68_20966046_ChIP-Seq_HELA_Human0.96478567
142HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96126674
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95209624
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.95072215
145* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94732519
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.94313757
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93058354
148PHF8_20622854_ChIP-Seq_HELA_Human0.92841168
149ATF3_27146783_Chip-Seq_COLON_Human0.92814981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.67773525
2MP0003111_abnormal_nucleus_morphology4.51219974
3MP0004957_abnormal_blastocyst_morpholog4.39574881
4MP0005058_abnormal_lysosome_morphology3.97982736
5MP0003077_abnormal_cell_cycle3.53553649
6MP0005451_abnormal_body_composition3.41758539
7MP0003646_muscle_fatigue3.20727088
8MP0010094_abnormal_chromosome_stability3.15022103
9MP0003123_paternal_imprinting2.63269052
10MP0008058_abnormal_DNA_repair2.62586111
11MP0010352_gastrointestinal_tract_polyps2.59850667
12MP0008260_abnormal_autophagy2.59620425
13MP0002653_abnormal_ependyma_morphology2.58598876
14MP0001730_embryonic_growth_arrest2.49897881
15MP0005171_absent_coat_pigmentation2.40314357
16MP0003806_abnormal_nucleotide_metabolis2.37931785
17MP0008932_abnormal_embryonic_tissue2.37286975
18MP0003453_abnormal_keratinocyte_physiol2.32879581
19MP0003329_amyloid_beta_deposits2.32046149
20MP0008007_abnormal_cellular_replicative2.26439887
21MP0005423_abnormal_somatic_nervous2.18192650
22MP0004133_heterotaxia2.14884276
23MP0000350_abnormal_cell_proliferation2.09134570
24MP0003172_abnormal_lysosome_physiology1.93070387
25MP0004859_abnormal_synaptic_plasticity1.88622685
26MP0001697_abnormal_embryo_size1.87005578
27MP0003436_decreased_susceptibility_to1.81656345
28MP0002080_prenatal_lethality1.80543203
29MP0002269_muscular_atrophy1.78015663
30MP0008057_abnormal_DNA_replication1.73994453
31MP0001672_abnormal_embryogenesis/_devel1.68281463
32MP0005380_embryogenesis_phenotype1.68281463
33MP0003786_premature_aging1.67446313
34MP0000358_abnormal_cell_content/1.64632571
35MP0009840_abnormal_foam_cell1.63643242
36MP0004510_myositis1.62500781
37MP0006036_abnormal_mitochondrial_physio1.61225881
38MP0002085_abnormal_embryonic_tissue1.57184646
39MP0005083_abnormal_biliary_tract1.55569188
40MP0003984_embryonic_growth_retardation1.55238506
41MP0001661_extended_life_span1.52143745
42MP0000313_abnormal_cell_death1.51847381
43MP0001986_abnormal_taste_sensitivity1.50529414
44MP0002088_abnormal_embryonic_growth/wei1.50447828
45MP0002254_reproductive_system_inflammat1.50378717
46MP0000604_amyloidosis1.47636901
47MP0004185_abnormal_adipocyte_glucose1.47405734
48MP0009278_abnormal_bone_marrow1.46958360
49MP0002084_abnormal_developmental_patter1.46257519
50MP0005076_abnormal_cell_differentiation1.45754939
51MP0000750_abnormal_muscle_regeneration1.44829119
52MP0005397_hematopoietic_system_phenotyp1.44146254
53MP0001545_abnormal_hematopoietic_system1.44146254
54MP0001348_abnormal_lacrimal_gland1.42976010
55MP0010030_abnormal_orbit_morphology1.42714839
56MP0003119_abnormal_digestive_system1.41476821
57MP0003705_abnormal_hypodermis_morpholog1.39802683
58MP0003075_altered_response_to1.37544233
59MP0003191_abnormal_cellular_cholesterol1.36233695
60MP0006072_abnormal_retinal_apoptosis1.35823548
61MP0003011_delayed_dark_adaptation1.33408920
62MP0010307_abnormal_tumor_latency1.31848718
63MP0004947_skin_inflammation1.31781393
64MP0002148_abnormal_hypersensitivity_rea1.31490668
65MP0006035_abnormal_mitochondrial_morpho1.28214469
66MP0002086_abnormal_extraembryonic_tissu1.28201677
67MP0000490_abnormal_crypts_of1.28108612
68MP0000858_altered_metastatic_potential1.26994642
69MP0003283_abnormal_digestive_organ1.26743204
70MP0000343_altered_response_to1.26504139
71MP0000681_abnormal_thyroid_gland1.18875106
72MP0009333_abnormal_splenocyte_physiolog1.18689541
73MP0002332_abnormal_exercise_endurance1.16978779
74MP0005623_abnormal_meninges_morphology1.16476874
75MP0002019_abnormal_tumor_incidence1.16471156
76MP0000749_muscle_degeneration1.14861471
77MP0008874_decreased_physiological_sensi1.14508729
78MP0000003_abnormal_adipose_tissue1.14057079
79MP0005257_abnormal_intraocular_pressure1.13737401
80MP0004197_abnormal_fetal_growth/weight/1.11659003
81MP0004233_abnormal_muscle_weight1.11404030
82MP0008877_abnormal_DNA_methylation1.11330831
83MP0001727_abnormal_embryo_implantation1.08121395
84MP0000747_muscle_weakness1.07816228
85MP0001502_abnormal_circadian_rhythm1.07124970
86MP0005266_abnormal_metabolism1.05218889
87MP0003186_abnormal_redox_activity1.02977192
88MP0002396_abnormal_hematopoietic_system1.02207847
89MP0002160_abnormal_reproductive_system1.01207711
90MP0003879_abnormal_hair_cell1.00272517
91MP0003567_abnormal_fetal_cardiomyocyte1.00219014
92MP0002796_impaired_skin_barrier0.99938854
93MP0003718_maternal_effect0.99132606
94MP0003221_abnormal_cardiomyocyte_apopto0.98223312
95MP0001346_abnormal_lacrimal_gland0.97931336
96MP0005025_abnormal_response_to0.95934650
97MP0003890_abnormal_embryonic-extraembry0.95807917
98MP0001873_stomach_inflammation0.95655941
99MP0009672_abnormal_birth_weight0.93326595
100MP0005220_abnormal_exocrine_pancreas0.93114160
101MP0005000_abnormal_immune_tolerance0.93010027
102MP0000537_abnormal_urethra_morphology0.92426307
103MP0003634_abnormal_glial_cell0.91882898
104MP0005375_adipose_tissue_phenotype0.91678898
105MP0005253_abnormal_eye_physiology0.90929234
106MP0003656_abnormal_erythrocyte_physiolo0.90506938
107MP0005384_cellular_phenotype0.89502943
108MP0001849_ear_inflammation0.88988498
109MP0009931_abnormal_skin_appearance0.88343431
110MP0000733_abnormal_muscle_development0.87645201
111MP0005330_cardiomyopathy0.87246353
112MP0004858_abnormal_nervous_system0.86049601
113MP0000013_abnormal_adipose_tissue0.85493739
114MP0003315_abnormal_perineum_morphology0.85452604
115MP0005666_abnormal_adipose_tissue0.84855797
116MP0004808_abnormal_hematopoietic_stem0.83875724
117MP0004087_abnormal_muscle_fiber0.82665304
118MP0002429_abnormal_blood_cell0.80921933
119MP0003303_peritoneal_inflammation0.80649161
120MP0001145_abnormal_male_reproductive0.80624142
121MP0002751_abnormal_autonomic_nervous0.80005606
122MP0008789_abnormal_olfactory_epithelium0.79930870
123MP0005621_abnormal_cell_physiology0.79027206
124MP0002249_abnormal_larynx_morphology0.77127187
125MP0005023_abnormal_wound_healing0.76976461
126MP0001764_abnormal_homeostasis0.76841359
127MP0002060_abnormal_skin_morphology0.75895200
128MP0003091_abnormal_cell_migration0.75790178
129MP0002398_abnormal_bone_marrow0.75201707
130MP0005551_abnormal_eye_electrophysiolog0.75057842
131MP0003763_abnormal_thymus_physiology0.73433220
132MP0003279_aneurysm0.72527539
133MP0005501_abnormal_skin_physiology0.72484942
134MP0000678_abnormal_parathyroid_gland0.72480467
135MP0008770_decreased_survivor_rate0.72470924
136MP0002089_abnormal_postnatal_growth/wei0.72254128
137MP0001905_abnormal_dopamine_level0.71393780
138MP0005584_abnormal_enzyme/coenzyme_acti0.70933116
139MP0000751_myopathy0.70488893
140MP0000703_abnormal_thymus_morphology0.69322598
141MP0001188_hyperpigmentation0.68496732
142MP0002210_abnormal_sex_determination0.68354395
143MP0002723_abnormal_immune_serum0.67756743
144MP0005499_abnormal_olfactory_system0.67600775
145MP0005394_taste/olfaction_phenotype0.67600775
146MP0000759_abnormal_skeletal_muscle0.67249804
147MP0000716_abnormal_immune_system0.66904026
148MP0000685_abnormal_immune_system0.66848427
149MP0005166_decreased_susceptibility_to0.66667779
150MP0005174_abnormal_tail_pigmentation0.66029627
151MP0002722_abnormal_immune_system0.65510268
152MP0004084_abnormal_cardiac_muscle0.64965353
153MP0002106_abnormal_muscle_physiology0.61761151
154MP0002111_abnormal_tail_morphology0.59258209
155MP0001293_anophthalmia0.59178273
156MP0000477_abnormal_intestine_morphology0.56235970
157MP0002877_abnormal_melanocyte_morpholog0.55668539

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.99575817
2Cerebral hypomyelination (HP:0006808)3.97031441
3Congenital stationary night blindness (HP:0007642)3.96104808
4Abnormal number of erythroid precursors (HP:0012131)3.77783207
5Oral leukoplakia (HP:0002745)3.61856113
6Mesangial abnormality (HP:0001966)3.50280206
7Progressive muscle weakness (HP:0003323)3.39907069
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.38925773
9Multiple enchondromatosis (HP:0005701)3.37002662
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34939123
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34939123
12Breast hypoplasia (HP:0003187)3.27396934
13Aplastic anemia (HP:0001915)3.26970622
14Reticulocytopenia (HP:0001896)3.23638814
15Ulnar bowing (HP:0003031)3.23300752
16Annular pancreas (HP:0001734)3.22269029
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.20373255
18Achilles tendon contracture (HP:0001771)3.17846769
19Abnormality of the anterior horn cell (HP:0006802)3.13440165
20Degeneration of anterior horn cells (HP:0002398)3.13440165
21Abnormality of liposaccharide metabolism (HP:0010968)3.10906442
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.10906442
23Abnormality of glycolipid metabolism (HP:0010969)3.10906442
24Birth length less than 3rd percentile (HP:0003561)3.10635836
25Trismus (HP:0000211)3.08297063
26Rough bone trabeculation (HP:0100670)3.05517832
27Selective tooth agenesis (HP:0001592)3.05044804
28Ependymoma (HP:0002888)2.98282156
29Hemorrhage of the eye (HP:0011885)2.97027980
30Microretrognathia (HP:0000308)2.94579671
31Carpal bone hypoplasia (HP:0001498)2.89729006
32Microvesicular hepatic steatosis (HP:0001414)2.82784625
33Neoplasm of the pancreas (HP:0002894)2.78195340
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73702986
35Increased cerebral lipofuscin (HP:0011813)2.72894472
36Broad distal phalanx of finger (HP:0009836)2.67863821
37Bony spicule pigmentary retinopathy (HP:0007737)2.66458414
38Abnormality of the Achilles tendon (HP:0005109)2.65462999
39Poikiloderma (HP:0001029)2.64414140
40Macrocytic anemia (HP:0001972)2.61621174
41Cholelithiasis (HP:0001081)2.61098678
42Distal lower limb amyotrophy (HP:0008944)2.60907369
43Hypertensive crisis (HP:0100735)2.60635602
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.60145039
45Abnormal rod and cone electroretinograms (HP:0008323)2.59993670
46Pendular nystagmus (HP:0012043)2.59678828
47Pallor (HP:0000980)2.58715407
48Upper limb amyotrophy (HP:0009129)2.58680679
49Distal upper limb amyotrophy (HP:0007149)2.58680679
50Thin bony cortex (HP:0002753)2.58098576
51Insomnia (HP:0100785)2.57104799
52Renal Fanconi syndrome (HP:0001994)2.56636181
53Colon cancer (HP:0003003)2.55409032
54Patellar aplasia (HP:0006443)2.55398907
55Premature ovarian failure (HP:0008209)2.55168403
56Adenoma sebaceum (HP:0009720)2.51462577
57Angiofibromas (HP:0010615)2.51462577
58Hyperacusis (HP:0010780)2.51194937
59Unsteady gait (HP:0002317)2.49935233
60Distal lower limb muscle weakness (HP:0009053)2.49128287
61Abnormal gallbladder physiology (HP:0012438)2.47908566
62Cholecystitis (HP:0001082)2.47908566
63Increased hepatocellular lipid droplets (HP:0006565)2.47039748
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.47024636
65Lipid accumulation in hepatocytes (HP:0006561)2.45779893
66Emotional lability (HP:0000712)2.43780898
67Difficulty climbing stairs (HP:0003551)2.43666757
68Increased serum lactate (HP:0002151)2.40231503
69Biliary tract neoplasm (HP:0100574)2.38856125
70Aplasia/Hypoplasia of the patella (HP:0006498)2.37753705
71Rectal prolapse (HP:0002035)2.34235784
72Neuronal loss in central nervous system (HP:0002529)2.33137797
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31032543
74Vertebral compression fractures (HP:0002953)2.28833842
75Ragged-red muscle fibers (HP:0003200)2.28251033
76Hepatocellular necrosis (HP:0001404)2.25101196
77Neonatal onset (HP:0003623)2.22390411
78Squamous cell carcinoma (HP:0002860)2.20917995
79Akinesia (HP:0002304)2.20524214
80Secondary amenorrhea (HP:0000869)2.18355775
81Joint stiffness (HP:0001387)2.18168031
82Stridor (HP:0010307)2.17718622
83Postnatal microcephaly (HP:0005484)2.16808826
84Rhabdomyolysis (HP:0003201)2.16807781
85Hypoplasia of the pons (HP:0012110)2.15262594
86Delusions (HP:0000746)2.15150937
87Personality changes (HP:0000751)2.14182327
88Turricephaly (HP:0000262)2.13685879
89Rib fusion (HP:0000902)2.13066365
90Missing ribs (HP:0000921)2.13022212
91Abnormal gallbladder morphology (HP:0012437)2.09681727
92Bulbar palsy (HP:0001283)2.08282018
93Hepatic necrosis (HP:0002605)2.08175132
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07957502
95Abnormality of reticulocytes (HP:0004312)2.07884825
96Late onset (HP:0003584)2.07732908
97Dyschromatopsia (HP:0007641)2.06818917
98Testicular atrophy (HP:0000029)2.06677924
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.05921666
100Myopathic facies (HP:0002058)2.05879026
101Cellular immunodeficiency (HP:0005374)2.04733706
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04673977
103Ankle clonus (HP:0011448)2.04481004
104Rapidly progressive (HP:0003678)2.02659819
105Dysostosis multiplex (HP:0000943)2.01414714
106Slender long bone (HP:0003100)2.01010008
107Absent thumb (HP:0009777)2.00513739
108Axonal loss (HP:0003447)1.99804029
109Reticulocytosis (HP:0001923)1.98629066
110CNS hypomyelination (HP:0003429)1.98592032
111Abnormal mitochondria in muscle tissue (HP:0008316)1.98201093
11211 pairs of ribs (HP:0000878)1.98105275
113Abnormality of the gallbladder (HP:0005264)1.97816294
114Neoplasm of the rectum (HP:0100743)1.95918945
115Pelvic girdle muscle weakness (HP:0003749)1.95236658
116Increased connective tissue (HP:0009025)1.95055049
117Supranuclear gaze palsy (HP:0000605)1.94191199
118Mitochondrial inheritance (HP:0001427)1.93935279
119Premature graying of hair (HP:0002216)1.93289753
120Long palpebral fissure (HP:0000637)1.92678759
121Abnormality of the intrinsic pathway (HP:0010989)1.91512127
122CNS demyelination (HP:0007305)1.91485498
123Myoglobinuria (HP:0002913)1.91478017
124Medulloblastoma (HP:0002885)1.90190454
125Loss of speech (HP:0002371)1.89857020
126Abnormal trabecular bone morphology (HP:0100671)1.89763582
127Horseshoe kidney (HP:0000085)1.89733434
128Increased CSF lactate (HP:0002490)1.89580354
129Esophageal neoplasm (HP:0100751)1.88980594
130Neoplasm of head and neck (HP:0012288)1.88980594
131Myotonia (HP:0002486)1.88421907
132Bowing of the arm (HP:0006488)1.87544596
133Bowed forearm bones (HP:0003956)1.87544596
134Lower limb amyotrophy (HP:0007210)1.86671757
135Type II diabetes mellitus (HP:0005978)1.86261999
136Absent radius (HP:0003974)1.85495543
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85143256
138Abnormality of abdominal situs (HP:0011620)1.84542427
139Abdominal situs inversus (HP:0003363)1.84542427
140Cerebellar dysplasia (HP:0007033)1.84319069
141Shoulder girdle muscle weakness (HP:0003547)1.84013843
142Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84001901
143Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84001901
144Abnormality of polysaccharide metabolism (HP:0011012)1.84001901
145Exercise intolerance (HP:0003546)1.83992974
146Atrioventricular block (HP:0001678)1.83964027
147Abnormality of the lower motor neuron (HP:0002366)1.83787452
148Deep palmar crease (HP:0006191)1.81981034
149Neoplasm of the colon (HP:0100273)1.80999274
150Easy fatigability (HP:0003388)1.80926006
151Vaginal fistula (HP:0004320)1.79998452
152Progressive external ophthalmoplegia (HP:0000590)1.79646515
153Retinal dysplasia (HP:0007973)1.77744484
154Cerebral inclusion bodies (HP:0100314)1.77253906
155Basal cell carcinoma (HP:0002671)1.76807805
156Hand muscle atrophy (HP:0009130)1.76520815
157Muscle fibrillation (HP:0010546)1.76047678
158Visual hallucinations (HP:0002367)1.75599919
159Increased muscle lipid content (HP:0009058)1.74699935
160Areflexia of lower limbs (HP:0002522)1.74658359
161Severe visual impairment (HP:0001141)1.74596316
162Generalized amyotrophy (HP:0003700)1.74021372
163Lactic acidosis (HP:0003128)1.73925831
164Zonular cataract (HP:0010920)1.73492113
165Prolonged neonatal jaundice (HP:0006579)1.73270147
166Megaloblastic anemia (HP:0001889)1.72943236
167Athetosis (HP:0002305)1.72901277
168Increased intramyocellular lipid droplets (HP:0012240)1.72616784
169Tongue fasciculations (HP:0001308)1.72024214
170Pointed chin (HP:0000307)1.71869467
171Diminished motivation (HP:0000745)1.71822666
172Failure to thrive in infancy (HP:0001531)1.71208559
173Diaphragmatic weakness (HP:0009113)1.71096119
174Neurofibrillary tangles (HP:0002185)1.70116274
175Delayed epiphyseal ossification (HP:0002663)1.69848142
176Abnormality of pyrimidine metabolism (HP:0004353)1.69053998
177Thoracic kyphosis (HP:0002942)1.68778678
178Increased serum ferritin (HP:0003281)1.68722471
179Absent forearm bone (HP:0003953)1.68633897
180Aplasia involving forearm bones (HP:0009822)1.68633897
181Abnormality of the pons (HP:0007361)1.68598582
182Spinal muscular atrophy (HP:0007269)1.68410333
183Acute necrotizing encephalopathy (HP:0006965)1.67900145
184Exercise-induced myalgia (HP:0003738)1.67180377
185Respiratory difficulties (HP:0002880)1.66779642
186Gastrointestinal dysmotility (HP:0002579)1.66746042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.17577801
2IRAK33.52256367
3WEE13.27695295
4NME23.09936206
5NEK13.00510207
6EIF2AK12.82962569
7SMG12.81193112
8TESK22.73116947
9EPHA22.65596494
10PRPF4B2.58118282
11MAP3K112.17120343
12CDC72.14024282
13TAOK22.07326361
14SCYL22.07116284
15BCKDK1.99266289
16MAPKAPK31.95866631
17TLK11.94678983
18NEK21.92690439
19TESK11.83415480
20MAPK151.79815388
21TTK1.78701427
22SIK11.67793934
23TSSK61.66998304
24PAK41.65795114
25STK161.65229345
26DYRK31.60976402
27AURKA1.60956323
28RPS6KB21.60466388
29TRIB31.56886705
30MAP3K81.56281705
31PLK11.55777361
32BRAF1.52024091
33PKN21.50670865
34VRK21.47623858
35PIM21.47388891
36CCNB11.47061964
37TBK11.36368384
38BRSK21.29839184
39EEF2K1.28734187
40CDK71.26662866
41RPS6KA41.25354200
42EIF2AK31.25192603
43AURKB1.21135887
44BRSK11.20812892
45LIMK11.18185780
46MAP3K101.17050534
47PASK1.14767826
48DAPK11.13501468
49MAP4K11.10486925
50FLT31.10091466
51ACVR1B1.04047742
52ABL21.03688871
53DAPK31.01987259
54SRPK10.99637671
55ARAF0.98073869
56PAK60.96427941
57SIK20.96386518
58PAK10.93757614
59CHEK20.92302760
60VRK10.92202994
61PRKCI0.92138845
62KDR0.91917597
63PLK40.91637691
64MAP2K20.89460541
65ERN10.88982430
66RPS6KA50.88154551
67IRAK20.87853768
68BMX0.87719940
69MAP3K10.86523077
70LRRK20.84551700
71MOS0.83280562
72ATR0.83007010
73MUSK0.82173391
74RIPK10.81843623
75ICK0.72803775
76DYRK1B0.71003874
77NME10.68873089
78PBK0.68320782
79PDK30.67065311
80PDK40.67065311
81CHEK10.66862861
82CDK40.65609973
83GRK60.65261444
84WNK30.65081111
85ZAK0.65065297
86CAMK2G0.64527137
87PLK30.64456041
88TAOK10.63515489
89PDPK10.60226493
90PRKD20.60143335
91ALK0.59699931
92STK100.58696939
93MAPK110.57580556
94CDK20.56841261
95DYRK20.52946767
96CSNK2A20.52867080
97NTRK10.51916356
98AKT20.51557900
99RPS6KL10.51291386
100RPS6KC10.51291386
101TTN0.50779797
102RPS6KA20.50734648
103LATS20.50652321
104MAP3K140.50391776
105IKBKB0.50314574
106MAP2K60.49245624
107MARK20.48944471
108CSNK1G30.48239481
109UHMK10.47972965
110STK40.47665429
111RAF10.47518042
112CAMKK10.45705103
113MAP3K130.45689311
114MAP2K30.43865320
115LMTK20.43195209
116RPS6KA60.43139155
117CSNK2A10.42992296
118ILK0.42845040
119MTOR0.42470340
120DDR20.41570402
121MAP2K70.41021909
122CDK11A0.40531713
123MYLK0.39847455
124CDK140.39258185
125CDK150.38770686
126BLK0.38492452
127CDK60.37854257
128CDC42BPA0.37589268
129CDK180.37502087
130KSR20.36732247
131CAMK2B0.36603197
132CSNK1A1L0.36578262
133MINK10.36131670
134MAP3K30.34444945
135HIPK20.34235857
136CDK120.33726662
137PRKD30.33661314
138ATM0.33501967
139MAP3K50.33363959
140MAP3K90.32556883
141PRKD10.31513391
142CAMKK20.31419118
143RPS6KA10.31162997
144IRAK40.31084956
145ZAP700.29655558
146PIM10.29505670

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31336181
2Proteasome_Homo sapiens_hsa030503.84996827
3Ribosome_Homo sapiens_hsa030103.80209052
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47158951
5Mismatch repair_Homo sapiens_hsa034303.46968095
6RNA polymerase_Homo sapiens_hsa030203.30619438
7Spliceosome_Homo sapiens_hsa030403.01462027
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.88537516
9RNA transport_Homo sapiens_hsa030132.82213082
10Base excision repair_Homo sapiens_hsa034102.81907984
11Pyrimidine metabolism_Homo sapiens_hsa002402.55379087
12Phototransduction_Homo sapiens_hsa047442.41474595
13Nucleotide excision repair_Homo sapiens_hsa034202.38026263
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.19472083
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.17729881
16One carbon pool by folate_Homo sapiens_hsa006702.15234730
17Cell cycle_Homo sapiens_hsa041102.02102361
18Homologous recombination_Homo sapiens_hsa034401.95117162
19Lysosome_Homo sapiens_hsa041421.93963151
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90127354
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88224956
22Folate biosynthesis_Homo sapiens_hsa007901.77925401
23Biosynthesis of amino acids_Homo sapiens_hsa012301.67494870
24Parkinsons disease_Homo sapiens_hsa050121.67348194
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63462154
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54181698
27Oxidative phosphorylation_Homo sapiens_hsa001901.45784150
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.44730515
29Sulfur relay system_Homo sapiens_hsa041221.44615873
30Huntingtons disease_Homo sapiens_hsa050161.40467059
31Purine metabolism_Homo sapiens_hsa002301.37361341
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35629309
33Prion diseases_Homo sapiens_hsa050201.27092965
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.23998397
35p53 signaling pathway_Homo sapiens_hsa041151.23452374
36RNA degradation_Homo sapiens_hsa030181.23232119
37mRNA surveillance pathway_Homo sapiens_hsa030151.22563870
38Carbon metabolism_Homo sapiens_hsa012001.20840434
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17594066
40Pentose phosphate pathway_Homo sapiens_hsa000301.17502713
41Salmonella infection_Homo sapiens_hsa051321.15201657
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.13565964
43VEGF signaling pathway_Homo sapiens_hsa043701.13186208
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.12836188
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11900357
46Systemic lupus erythematosus_Homo sapiens_hsa053221.04048826
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03022359
48Thyroid cancer_Homo sapiens_hsa052161.01083582
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99871698
50Fanconi anemia pathway_Homo sapiens_hsa034600.98725657
51Epstein-Barr virus infection_Homo sapiens_hsa051690.96122119
52Galactose metabolism_Homo sapiens_hsa000520.95767727
53Endocytosis_Homo sapiens_hsa041440.93277776
54Basal transcription factors_Homo sapiens_hsa030220.93152422
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92362525
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88537276
57Protein export_Homo sapiens_hsa030600.88168239
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87967030
59Selenocompound metabolism_Homo sapiens_hsa004500.86911985
60Oocyte meiosis_Homo sapiens_hsa041140.82590446
61Collecting duct acid secretion_Homo sapiens_hsa049660.81961097
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79602863
63Cardiac muscle contraction_Homo sapiens_hsa042600.76734614
64Alzheimers disease_Homo sapiens_hsa050100.76291130
65Alcoholism_Homo sapiens_hsa050340.75006617
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.74185837
67Bladder cancer_Homo sapiens_hsa052190.72507897
68Phenylalanine metabolism_Homo sapiens_hsa003600.71033491
69Sphingolipid metabolism_Homo sapiens_hsa006000.70845016
70Herpes simplex infection_Homo sapiens_hsa051680.70336362
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69210390
72Tuberculosis_Homo sapiens_hsa051520.68905234
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.68743979
74B cell receptor signaling pathway_Homo sapiens_hsa046620.68662101
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67553332
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65524143
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65187713
78Viral carcinogenesis_Homo sapiens_hsa052030.62372581
79Sulfur metabolism_Homo sapiens_hsa009200.60949830
80Non-homologous end-joining_Homo sapiens_hsa034500.60929914
81N-Glycan biosynthesis_Homo sapiens_hsa005100.60770700
82Regulation of autophagy_Homo sapiens_hsa041400.60092442
83Vitamin B6 metabolism_Homo sapiens_hsa007500.59117663
84Osteoclast differentiation_Homo sapiens_hsa043800.58968679
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58504128
86Non-small cell lung cancer_Homo sapiens_hsa052230.58396444
87Hepatitis C_Homo sapiens_hsa051600.55082203
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54100604
89Glutathione metabolism_Homo sapiens_hsa004800.53110208
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53021231
91Rheumatoid arthritis_Homo sapiens_hsa053230.52871177
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52558973
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52359041
94Pyruvate metabolism_Homo sapiens_hsa006200.52331387
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51207814
96Hepatitis B_Homo sapiens_hsa051610.50054944
97Arginine and proline metabolism_Homo sapiens_hsa003300.49838561
98TNF signaling pathway_Homo sapiens_hsa046680.49133236
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46679173
100Pertussis_Homo sapiens_hsa051330.46021010
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45947270
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.45614774
103Metabolic pathways_Homo sapiens_hsa011000.44639664
104Notch signaling pathway_Homo sapiens_hsa043300.43393987
105mTOR signaling pathway_Homo sapiens_hsa041500.42558771
106Influenza A_Homo sapiens_hsa051640.40920660
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.40845724
108Viral myocarditis_Homo sapiens_hsa054160.40726058
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40683489
110Pancreatic cancer_Homo sapiens_hsa052120.40353673
111HTLV-I infection_Homo sapiens_hsa051660.39352424
112HIF-1 signaling pathway_Homo sapiens_hsa040660.37940656
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.37840588
114Phagosome_Homo sapiens_hsa041450.37083719
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36774452
116Legionellosis_Homo sapiens_hsa051340.35356219
117Toxoplasmosis_Homo sapiens_hsa051450.35209134
118Leishmaniasis_Homo sapiens_hsa051400.33680107
119Antigen processing and presentation_Homo sapiens_hsa046120.32896156
120Synaptic vesicle cycle_Homo sapiens_hsa047210.31375235
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30456283
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29998444
123Apoptosis_Homo sapiens_hsa042100.26399156
124Chronic myeloid leukemia_Homo sapiens_hsa052200.19725328
125Fat digestion and absorption_Homo sapiens_hsa049750.19305554
126Other glycan degradation_Homo sapiens_hsa005110.18216159
127Hedgehog signaling pathway_Homo sapiens_hsa043400.18209363
128Hippo signaling pathway_Homo sapiens_hsa043900.18093727
129Vibrio cholerae infection_Homo sapiens_hsa051100.16725125
130Shigellosis_Homo sapiens_hsa051310.16141958
131Tight junction_Homo sapiens_hsa045300.14972700
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14836271
133Insulin signaling pathway_Homo sapiens_hsa049100.14649804
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14595916
135Acute myeloid leukemia_Homo sapiens_hsa052210.14549861
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14182296
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11425071
138AMPK signaling pathway_Homo sapiens_hsa041520.09811708
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09277949
140Glucagon signaling pathway_Homo sapiens_hsa049220.08160868

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