DOK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08836028
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08836028
3antigen processing and presentation of endogenous antigen (GO:0019883)4.96719941
4negative regulation of cell killing (GO:0031342)4.83349541
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.83349541
6NIK/NF-kappaB signaling (GO:0038061)4.54494368
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48701765
8detection of other organism (GO:0098543)4.20573506
9detection of bacterium (GO:0016045)4.12066042
10regulation of mast cell degranulation (GO:0043304)3.88272098
11cellular extravasation (GO:0045123)3.81575293
12positive regulation of natural killer cell differentiation (GO:0032825)3.58169201
13positive regulation of gamma-delta T cell activation (GO:0046645)3.57531276
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.57408648
15detection of external biotic stimulus (GO:0098581)3.55502050
16regulation of mast cell activation involved in immune response (GO:0033006)3.54255133
17regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49361611
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.48724202
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46907298
20response to host immune response (GO:0052572)3.46907298
21neutrophil activation involved in immune response (GO:0002283)3.46878032
22regulation of leukocyte degranulation (GO:0043300)3.46093197
23positive regulation of interferon-alpha production (GO:0032727)3.44167752
24positive regulation of mast cell activation (GO:0033005)3.43681039
25leukocyte aggregation (GO:0070486)3.38143273
26natural killer cell mediated immunity (GO:0002228)3.35252143
27natural killer cell mediated cytotoxicity (GO:0042267)3.35252143
28myeloid cell activation involved in immune response (GO:0002275)3.34271978
29immunoglobulin mediated immune response (GO:0016064)3.33398135
30regulation of interferon-alpha production (GO:0032647)3.27622604
31regulation of dendritic cell antigen processing and presentation (GO:0002604)3.26303494
32response to muramyl dipeptide (GO:0032495)3.25374240
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.23007677
34detection of molecule of bacterial origin (GO:0032490)3.22490983
35response to host (GO:0075136)3.22205613
36response to host defenses (GO:0052200)3.22205613
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22205613
38regulation of interferon-beta biosynthetic process (GO:0045357)3.19092986
39myeloid dendritic cell differentiation (GO:0043011)3.18149943
40amino sugar catabolic process (GO:0046348)3.13863994
41regulation of mast cell activation (GO:0033003)3.13485886
42regulation of T-helper 1 cell differentiation (GO:0045625)3.13172522
43detection of biotic stimulus (GO:0009595)3.12409929
44antigen processing and presentation via MHC class Ib (GO:0002475)3.11447432
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.11423669
46positive regulation of mast cell degranulation (GO:0043306)3.11423669
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10996185
48microglial cell activation (GO:0001774)3.07967093
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.07160704
50dendritic cell differentiation (GO:0097028)3.06940786
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05183328
52regulation of necroptotic process (GO:0060544)3.01484646
53regulation of protein heterodimerization activity (GO:0043497)2.99879833
54positive thymic T cell selection (GO:0045059)2.98990677
55regulation of antigen processing and presentation (GO:0002577)2.98030919
56negative regulation of leukocyte mediated immunity (GO:0002704)2.97643164
57positive regulation by symbiont of host defense response (GO:0052509)2.96853225
58modulation by symbiont of host defense response (GO:0052031)2.96853225
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96853225
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96853225
61positive regulation by organism of defense response of other organism involved in symbiotic interact2.96853225
62modulation by symbiont of host immune response (GO:0052553)2.96853225
63myeloid dendritic cell activation (GO:0001773)2.96295253
64negative regulation of lymphocyte mediated immunity (GO:0002707)2.95246265
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93113177
66macrophage activation (GO:0042116)2.91918622
67response to peptidoglycan (GO:0032494)2.90008549
68viral transcription (GO:0019083)2.88837330
69negative regulation of innate immune response (GO:0045824)2.88627213
70natural killer cell differentiation (GO:0001779)2.88466544
71positive regulation of B cell differentiation (GO:0045579)2.88397407
72pinocytosis (GO:0006907)2.87280924
73positive regulation of antigen processing and presentation (GO:0002579)2.87033584
74response to type I interferon (GO:0034340)2.86610825
75T cell apoptotic process (GO:0070231)2.84579409
76germinal center formation (GO:0002467)2.84090974
77type I interferon signaling pathway (GO:0060337)2.83756156
78cellular response to type I interferon (GO:0071357)2.83756156
79B cell mediated immunity (GO:0019724)2.81951706
80negative regulation of phagocytosis (GO:0050765)2.81715930
81response to interferon-alpha (GO:0035455)2.81170504
82T cell migration (GO:0072678)2.79831116
83negative regulation of interleukin-12 production (GO:0032695)2.78547204
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78179554
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77008237
86positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.76955490
87ribosomal small subunit assembly (GO:0000028)2.75501900
88leukocyte degranulation (GO:0043299)2.75248374
89neutrophil activation (GO:0042119)2.74792084
90translational termination (GO:0006415)2.74775060
91negative regulation of interleukin-6 production (GO:0032715)2.74139811
92leukocyte migration involved in inflammatory response (GO:0002523)2.73553446
93regulation of macrophage cytokine production (GO:0010935)2.71845622
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71665514
95interferon-gamma-mediated signaling pathway (GO:0060333)2.71071733
96regulation of B cell receptor signaling pathway (GO:0050855)2.70078157
97negative regulation of cytokine production involved in immune response (GO:0002719)2.69975186
98regulation of superoxide anion generation (GO:0032928)2.69861333
99granulocyte activation (GO:0036230)2.69839577
100negative regulation of T cell mediated immunity (GO:0002710)2.69734914
101regulation of regulated secretory pathway (GO:1903305)2.69402022
102actin nucleation (GO:0045010)2.65219636
103regulation of RIG-I signaling pathway (GO:0039535)2.65027462
104positive regulation of leukocyte degranulation (GO:0043302)2.64856319
105regulation of integrin activation (GO:0033623)2.64704048
106T-helper 1 type immune response (GO:0042088)2.64164276
107negative regulation of myeloid cell apoptotic process (GO:0033033)2.62711913
108regulation of T-helper 2 cell differentiation (GO:0045628)2.62333914
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62239952
110mannose metabolic process (GO:0006013)2.61701222
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61464666
112mature B cell differentiation (GO:0002335)2.58681787
113regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58449314
114regulation of B cell differentiation (GO:0045577)2.57924000
115platelet aggregation (GO:0070527)2.55343444
116cellular response to zinc ion (GO:0071294)2.55180089
117response to interferon-beta (GO:0035456)2.54964070
118regulation of gamma-delta T cell differentiation (GO:0045586)2.54678254
119positive regulation of interferon-beta production (GO:0032728)2.54459139
120activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.52276264
121regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.49321887
122lymphocyte apoptotic process (GO:0070227)2.45900950
123regulation of interleukin-12 production (GO:0032655)2.45861094
124positive regulation of macrophage differentiation (GO:0045651)2.44233992
125negative regulation of necroptotic process (GO:0060546)2.43586955
126cell adhesion mediated by integrin (GO:0033627)2.43313178
127mature B cell differentiation involved in immune response (GO:0002313)2.43233233
128cellular response to interferon-alpha (GO:0035457)2.42079293
129translational elongation (GO:0006414)2.41916181
130negative regulation of erythrocyte differentiation (GO:0045647)2.41268050
131hepatocyte apoptotic process (GO:0097284)2.40792765
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.39668099
133cellular response to interferon-beta (GO:0035458)2.38999527
134regulation of gamma-delta T cell activation (GO:0046643)2.38157265
135myeloid cell homeostasis (GO:0002262)2.37940256
136barbed-end actin filament capping (GO:0051016)2.36250098
137positive regulation of protein oligomerization (GO:0032461)2.34821467
138regulation of alpha-beta T cell proliferation (GO:0046640)2.34380115
139regulation of natural killer cell differentiation (GO:0032823)2.34078181
140regulation of necrotic cell death (GO:0010939)2.33815283
141macrophage activation involved in immune response (GO:0002281)2.32999091
142positive regulation of interleukin-12 production (GO:0032735)2.32920768
143defense response to protozoan (GO:0042832)2.31255471
144regulation of response to interferon-gamma (GO:0060330)2.31146697
145respiratory burst (GO:0045730)2.30535604
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.29856290
147B cell receptor signaling pathway (GO:0050853)2.29634309
148lymphocyte mediated immunity (GO:0002449)2.29407980
149positive regulation of natural killer cell activation (GO:0032816)2.29185761
150SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.27593497
151leukocyte cell-cell adhesion (GO:0007159)2.27263488
152response to protozoan (GO:0001562)2.27221001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.95395963
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.49125872
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.42618461
4E2F7_22180533_ChIP-Seq_HELA_Human3.31232941
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79374329
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.77753379
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76749765
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68065745
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67212396
10MYC_22102868_ChIP-Seq_BL_Human2.58515647
11VDR_21846776_ChIP-Seq_THP-1_Human2.49798142
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47438638
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36020084
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31164620
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.28713440
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23809955
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19215408
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17877349
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11437334
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10494323
21MAF_26560356_Chip-Seq_TH1_Human2.00561683
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.00131076
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99675958
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98625551
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.93846261
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93547021
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92926715
28SPI1_23547873_ChIP-Seq_NB4_Human1.88188289
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.87966782
30MYB_26560356_Chip-Seq_TH2_Human1.80104314
31VDR_24763502_ChIP-Seq_THP-1_Human1.79781219
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78179153
33SCL_19346495_ChIP-Seq_HPC-7_Human1.78061019
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77352455
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73120926
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.72262051
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.71842585
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68855783
39TCF7_22412390_ChIP-Seq_EML_Mouse1.66242340
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65143136
41UTX_26944678_Chip-Seq_JUKART_Human1.63115610
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58603309
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57690166
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57626524
45MYB_26560356_Chip-Seq_TH1_Human1.57386315
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57296502
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.49508072
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.49238656
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45403417
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42591019
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42441222
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42196224
53TFEB_21752829_ChIP-Seq_HELA_Human1.42194116
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42119259
55BCL6_27268052_Chip-Seq_Bcells_Human1.40515986
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39978921
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38560592
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37336414
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36282333
60MAF_26560356_Chip-Seq_TH2_Human1.35764906
61* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34994828
62KDM2B_26808549_Chip-Seq_DND41_Human1.33847660
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31665001
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.31271352
65SPI1_23127762_ChIP-Seq_K562_Human1.28032152
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27473773
67GATA1_19941826_ChIP-Seq_K562_Human1.27355297
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27259803
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27062383
70GATA1_22025678_ChIP-Seq_K562_Human1.26103016
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25666086
72BCOR_27268052_Chip-Seq_Bcells_Human1.25161272
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22650710
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21753447
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20988403
76* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19188740
77RUNX_20019798_ChIP-Seq_JUKART_Human1.18628374
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18339925
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18136440
80VDR_24787735_ChIP-Seq_THP-1_Human1.16958997
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16628844
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16346148
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16206855
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15770474
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15079560
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.14088187
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13961974
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13210400
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13159636
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13051279
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12676698
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11626476
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10652749
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09656569
95E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09624406
96NCOR1_26117541_ChIP-Seq_K562_Human1.09371566
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09331893
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08355682
99MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07495052
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.07104910
101XRN2_22483619_ChIP-Seq_HELA_Human1.06409821
102PU_27001747_Chip-Seq_BMDM_Mouse1.06183716
103P68_20966046_ChIP-Seq_HELA_Human1.06128814
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05954793
105ATF3_27146783_Chip-Seq_COLON_Human1.05770192
106* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05142756
107TRIM28_21343339_ChIP-Seq_HEK293_Human1.04108672
108SPI1_20517297_ChIP-Seq_HL60_Human1.01062324
109GATA2_21666600_ChIP-Seq_HMVEC_Human1.01048294
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00003892
111LXR_22292898_ChIP-Seq_THP-1_Human0.99688006
112* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98679839
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.98268648
114HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98161308
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.97719789
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95886034
117GATA3_27048872_Chip-Seq_THYMUS_Human0.95589900
118NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95460177
119HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95414014
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94993402
121RACK7_27058665_Chip-Seq_MCF-7_Human0.94486877
122DCP1A_22483619_ChIP-Seq_HELA_Human0.94257268
123MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93770878
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93460898
125* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92549311
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92124797
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.92124797
128VDR_23849224_ChIP-Seq_CD4+_Human0.91117708
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90971082
130CLOCK_20551151_ChIP-Seq_293T_Human0.90110254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.32141395
2MP0000685_abnormal_immune_system3.05716052
3MP0008438_abnormal_cutaneous_collagen2.85742503
4MP0003436_decreased_susceptibility_to2.71740772
5MP0003303_peritoneal_inflammation2.61481571
6MP0010352_gastrointestinal_tract_polyps2.52046492
7MP0005387_immune_system_phenotype2.32339489
8MP0001790_abnormal_immune_system2.32339489
9MP0009785_altered_susceptibility_to2.32165167
10MP0005000_abnormal_immune_tolerance2.27324578
11MP0003705_abnormal_hypodermis_morpholog2.23034353
12* MP0002452_abnormal_antigen_presenting2.18421398
13* MP0001800_abnormal_humoral_immune2.17386674
14MP0005671_abnormal_response_to2.15886725
15MP0002148_abnormal_hypersensitivity_rea2.03351044
16MP0002166_altered_tumor_susceptibility2.01502998
17MP0005025_abnormal_response_to2.01492577
18MP0004510_myositis1.99198462
19* MP0002419_abnormal_innate_immunity1.98129851
20* MP0002723_abnormal_immune_serum1.96527257
21* MP0001819_abnormal_immune_cell1.91893543
22MP0001545_abnormal_hematopoietic_system1.91698071
23MP0005397_hematopoietic_system_phenotyp1.91698071
24* MP0002420_abnormal_adaptive_immunity1.91218588
25MP0003300_gastrointestinal_ulcer1.88701790
26MP0002396_abnormal_hematopoietic_system1.88453735
27MP0003566_abnormal_cell_adhesion1.84189238
28MP0009333_abnormal_splenocyte_physiolog1.82731760
29MP0002877_abnormal_melanocyte_morpholog1.81870094
30* MP0002398_abnormal_bone_marrow1.80966032
31MP0006082_CNS_inflammation1.77635725
32MP0002405_respiratory_system_inflammati1.75709000
33MP0004808_abnormal_hematopoietic_stem1.74944227
34MP0005464_abnormal_platelet_physiology1.71104435
35MP0003279_aneurysm1.70176027
36MP0005058_abnormal_lysosome_morphology1.68129908
37MP0004947_skin_inflammation1.66109833
38MP0002006_tumorigenesis1.65592698
39MP0000858_altered_metastatic_potential1.65366407
40MP0001853_heart_inflammation1.64590960
41MP0001533_abnormal_skeleton_physiology1.64103757
42MP0008260_abnormal_autophagy1.63155970
43MP0003075_altered_response_to1.62214434
44* MP0000716_abnormal_immune_system1.60564839
45MP0010307_abnormal_tumor_latency1.59500553
46MP0003448_altered_tumor_morphology1.59143241
47MP0001348_abnormal_lacrimal_gland1.58485640
48MP0005023_abnormal_wound_healing1.56980573
49MP0003091_abnormal_cell_migration1.56762447
50MP0003828_pulmonary_edema1.55242729
51MP0009278_abnormal_bone_marrow1.50208125
52* MP0000689_abnormal_spleen_morphology1.49536903
53* MP0002722_abnormal_immune_system1.47661582
54* MP0002429_abnormal_blood_cell1.44894147
55MP0005451_abnormal_body_composition1.43681003
56MP0010155_abnormal_intestine_physiology1.42517600
57MP0000604_amyloidosis1.41517713
58MP0006054_spinal_hemorrhage1.36647085
59MP0002933_joint_inflammation1.35872340
60MP0001845_abnormal_inflammatory_respons1.35658163
61MP0000490_abnormal_crypts_of1.35369290
62MP0003763_abnormal_thymus_physiology1.35354662
63MP0003656_abnormal_erythrocyte_physiolo1.34390106
64MP0001958_emphysema1.32820948
65MP0005076_abnormal_cell_differentiation1.32166578
66MP0003183_abnormal_peptide_metabolism1.32024870
67MP0001873_stomach_inflammation1.30263489
68MP0005275_abnormal_skin_tensile1.27045903
69MP0002138_abnormal_hepatobiliary_system1.25391840
70MP0003724_increased_susceptibility_to1.22881188
71MP0003172_abnormal_lysosome_physiology1.19575733
72MP0000343_altered_response_to1.19464361
73MP0001851_eye_inflammation1.18044393
74MP0002163_abnormal_gland_morphology1.17534682
75MP0002254_reproductive_system_inflammat1.12510424
76MP0003866_abnormal_defecation1.11188381
77MP0002998_abnormal_bone_remodeling1.09892971
78MP0003806_abnormal_nucleotide_metabolis1.08794692
79MP0008469_abnormal_protein_level1.08721833
80MP0005257_abnormal_intraocular_pressure1.08615382
81* MP0000703_abnormal_thymus_morphology1.08391131
82MP0005310_abnormal_salivary_gland1.06919352
83MP0005390_skeleton_phenotype1.05379179
84MP0000733_abnormal_muscle_development1.04791285
85MP0008007_abnormal_cellular_replicative1.02218907
86MP0002132_abnormal_respiratory_system1.00734686
87MP0009840_abnormal_foam_cell1.00475039
88MP0001243_abnormal_dermal_layer0.97717049
89MP0005166_decreased_susceptibility_to0.97341919
90MP0000465_gastrointestinal_hemorrhage0.96926726
91MP0009763_increased_sensitivity_to0.95978833
92* MP0002019_abnormal_tumor_incidence0.95480932
93MP0008004_abnormal_stomach_pH0.94965535
94MP0003453_abnormal_keratinocyte_physiol0.92718594
95MP0003693_abnormal_embryo_hatching0.92377912
96MP0004883_abnormal_blood_vessel0.92115835
97MP0000767_abnormal_smooth_muscle0.91460522
98MP0005164_abnormal_response_to0.89993029
99MP0001663_abnormal_digestive_system0.89984243
100MP0000015_abnormal_ear_pigmentation0.88778278
101MP0003077_abnormal_cell_cycle0.88093558
102MP0003690_abnormal_glial_cell0.87740549
103MP0005174_abnormal_tail_pigmentation0.82744343
104MP0005503_abnormal_tendon_morphology0.82461229
105MP0005623_abnormal_meninges_morphology0.81692681
106MP0005165_increased_susceptibility_to0.79600289
107MP0003045_fibrosis0.78704940
108MP0003795_abnormal_bone_structure0.77957759
109MP0003329_amyloid_beta_deposits0.75337460
110MP0003191_abnormal_cellular_cholesterol0.74934795
111MP0009764_decreased_sensitivity_to0.74403966
112MP0005621_abnormal_cell_physiology0.73957264
113MP0001915_intracranial_hemorrhage0.73815143
114MP0000249_abnormal_blood_vessel0.72956323
115* MP0000350_abnormal_cell_proliferation0.72518685
116MP0003111_abnormal_nucleus_morphology0.72409876
117MP0002060_abnormal_skin_morphology0.71987837
118MP0001542_abnormal_bone_strength0.70765120
119MP0000313_abnormal_cell_death0.70313547
120MP0008874_decreased_physiological_sensi0.66448438
121MP0009765_abnormal_xenobiotic_induced0.58547354
122MP0004185_abnormal_adipocyte_glucose0.56131810
123MP0005319_abnormal_enzyme/_coenzyme0.56042421
124MP0005381_digestive/alimentary_phenotyp0.55290703
125MP0000609_abnormal_liver_physiology0.53304186

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.05137829
2Premature rupture of membranes (HP:0001788)3.80453313
3Peritonitis (HP:0002586)3.77384159
4Recurrent abscess formation (HP:0002722)3.70554284
5Eczematoid dermatitis (HP:0000976)3.69770846
6Vertebral compression fractures (HP:0002953)3.45353434
7Purpura (HP:0000979)3.42520334
8Elevated erythrocyte sedimentation rate (HP:0003565)3.39540950
9Stomatitis (HP:0010280)3.31696697
10Recurrent bacterial skin infections (HP:0005406)3.26169802
11Chronic otitis media (HP:0000389)3.13553083
12Hepatosplenomegaly (HP:0001433)3.11283171
13Nasal polyposis (HP:0100582)3.06832233
14Thrombocytosis (HP:0001894)3.05588951
15Recurrent bronchitis (HP:0002837)3.05161553
16Myositis (HP:0100614)3.01611640
17Cellulitis (HP:0100658)3.00322582
18Recurrent viral infections (HP:0004429)3.00252952
19Recurrent fungal infections (HP:0002841)2.97397778
20Abnormality of the nasal mucosa (HP:0000433)2.89415360
21Cerebral aneurysm (HP:0004944)2.85346509
22Urticaria (HP:0001025)2.79701037
23Abnormality of glycolipid metabolism (HP:0010969)2.78251453
24Abnormality of liposaccharide metabolism (HP:0010968)2.78251453
25Abnormality of glycosphingolipid metabolism (HP:0004343)2.78251453
26Abnormality of macrophages (HP:0004311)2.77639728
27Increased neuronal autofluorescent lipopigment (HP:0002074)2.77138651
28Osteolytic defects of the hand bones (HP:0009699)2.76359286
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.76359286
30Retrobulbar optic neuritis (HP:0100654)2.76025363
31Optic neuritis (HP:0100653)2.76025363
32Gingivitis (HP:0000230)2.75464097
33Increased density of long bones (HP:0006392)2.70651418
34Loss of speech (HP:0002371)2.65910011
35Hypertensive crisis (HP:0100735)2.63871783
36Cervical subluxation (HP:0003308)2.63247479
37Petechiae (HP:0000967)2.62024027
38Gingival bleeding (HP:0000225)2.61914438
39Encephalitis (HP:0002383)2.57451827
40Autoimmune thrombocytopenia (HP:0001973)2.54361824
41Amyloidosis (HP:0011034)2.52056281
42Mediastinal lymphadenopathy (HP:0100721)2.52007295
43Dysostosis multiplex (HP:0000943)2.51749201
44Panhypogammaglobulinemia (HP:0003139)2.51153383
45Gastrointestinal stroma tumor (HP:0100723)2.50304680
46Dilatation of the ascending aorta (HP:0005111)2.48351537
47Hematochezia (HP:0002573)2.46976550
48Interstitial pulmonary disease (HP:0006530)2.46489657
49Chest pain (HP:0100749)2.45335771
50Aortic dissection (HP:0002647)2.43915096
51Mucopolysacchariduria (HP:0008155)2.42908355
52Urinary glycosaminoglycan excretion (HP:0003541)2.42908355
53Orchitis (HP:0100796)2.39082414
54Increased IgM level (HP:0003496)2.38656672
55Thoracolumbar scoliosis (HP:0002944)2.38496951
56Aortic aneurysm (HP:0004942)2.35866057
57Recurrent skin infections (HP:0001581)2.35491119
58Pustule (HP:0200039)2.34841383
59Vasculitis (HP:0002633)2.32166769
60Emphysema (HP:0002097)2.30732218
61Abnormality of iron homeostasis (HP:0011031)2.29683891
62J-shaped sella turcica (HP:0002680)2.28300720
63Beaking of vertebral bodies (HP:0004568)2.28259653
64Vacuolated lymphocytes (HP:0001922)2.24070679
65Myocardial infarction (HP:0001658)2.23980650
66Hemoptysis (HP:0002105)2.23040995
67Abnormality of the peritoneum (HP:0002585)2.22957806
68Fatigue (HP:0012378)2.20503577
69Abnormality of cells of the erythroid lineage (HP:0012130)2.19989789
70Increased cerebral lipofuscin (HP:0011813)2.19881012
71Recurrent cutaneous fungal infections (HP:0011370)2.18638620
72Chronic mucocutaneous candidiasis (HP:0002728)2.18638620
73Upper motor neuron abnormality (HP:0002127)2.17054512
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.15892500
75Abnormality of polysaccharide metabolism (HP:0011012)2.14669291
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14669291
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14669291
78Recurrent gram-negative bacterial infections (HP:0005420)2.14619087
79Episodic fever (HP:0001954)2.13804874
80Abnormality of the acetabulum (HP:0003170)2.11057176
81Abnormal platelet volume (HP:0011876)2.10585864
82Ankle contracture (HP:0006466)2.10401409
83Abnormality of the lumbar spine (HP:0100712)2.09554597
84Restrictive lung disease (HP:0002091)2.08713706
85Colitis (HP:0002583)2.07608987
86Increased serum ferritin (HP:0003281)2.06014105
87Recurrent lower respiratory tract infections (HP:0002783)2.05648256
88Thoracic kyphosis (HP:0002942)2.05542612
89Biconcave vertebral bodies (HP:0004586)2.05445751
90Disinhibition (HP:0000734)2.05204944
91Gastrointestinal inflammation (HP:0004386)2.05010968
92Prolonged bleeding time (HP:0003010)2.04595675
93Pulmonary infiltrates (HP:0002113)2.04224432
94Inflammation of the large intestine (HP:0002037)2.03191844
95Polycythemia (HP:0001901)2.02491746
96Spondylolisthesis (HP:0003302)2.02054136
97Lymphopenia (HP:0001888)2.01926022
98Granulocytopenia (HP:0001913)2.01173154
99Chronic obstructive pulmonary disease (HP:0006510)2.00364623
100Obstructive lung disease (HP:0006536)2.00364623
101Genu recurvatum (HP:0002816)2.00199453
102Osteomyelitis (HP:0002754)1.99682899
103Abnormality of T cell physiology (HP:0011840)1.98782473
104Flat acetabular roof (HP:0003180)1.98725955
105Arterial thrombosis (HP:0004420)1.98570536
106Abnormal number of erythroid precursors (HP:0012131)1.98511285
107Epistaxis (HP:0000421)1.98042990
108Radial bowing (HP:0002986)1.96538667
109Keratoconjunctivitis sicca (HP:0001097)1.95861124
110Ulnar bowing (HP:0003031)1.94498809
111Abnormality of T cells (HP:0002843)1.93677608
112Meningitis (HP:0001287)1.93421199
113Leukocytosis (HP:0001974)1.92951600
114Hypergammaglobulinemia (HP:0010702)1.92234709
115Increased mean platelet volume (HP:0011877)1.91666716
116IgM deficiency (HP:0002850)1.91640794
117Gastrointestinal infarctions (HP:0005244)1.91551529
118Abnormality of cells of the lymphoid lineage (HP:0012140)1.89804282
119Mitral valve prolapse (HP:0001634)1.89495476
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89171953
121Arthralgia (HP:0002829)1.88721488
122Basal ganglia calcification (HP:0002135)1.88426037
123Periodontitis (HP:0000704)1.87335384
124Glomerulopathy (HP:0100820)1.86880949
125Spontaneous hematomas (HP:0007420)1.85752460
126Polygenic inheritance (HP:0010982)1.85304924
127Agammaglobulinemia (HP:0004432)1.85301171
128Increased IgE level (HP:0003212)1.84447643
129Recurrent pneumonia (HP:0006532)1.84384771
130Joint stiffness (HP:0001387)1.83917181
131Systemic lupus erythematosus (HP:0002725)1.83737886
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83549861
133Abnormal platelet function (HP:0011869)1.83376861
134Impaired platelet aggregation (HP:0003540)1.83376861

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.09972130
2NME22.92192446
3TRIB32.82524791
4ERN12.82227860
5TBK12.74771070
6TYK22.50714387
7FES2.41286274
8JAK32.40703466
9MAP3K142.38341145
10PRPF4B2.36599131
11PIM22.20226641
12MAP3K102.13076348
13EEF2K2.09524896
14PKN21.99434278
15LRRK21.97113321
16BLK1.96327396
17KIT1.94715519
18STK101.92052176
19RPS6KA41.91940919
20TTN1.86918826
21* IKBKB1.82841488
22TNK21.71387939
23IKBKE1.69147530
24SMG11.62685269
25ZAP701.54553924
26TESK21.53533032
27CSF1R1.51905740
28MAP2K31.51029059
29FLT31.50209039
30JAK11.49427710
31TGFBR21.43011283
32TESK11.38188347
33TAOK21.38136015
34MAP3K131.35753053
35BMX1.30896893
36CHUK1.30748835
37IRAK41.27539788
38SCYL21.25153686
39PIM11.23494456
40MAP3K111.22272582
41TRPM71.17634963
42PAK41.16855230
43BTK1.14113499
44MOS1.09354405
45EPHB11.08922631
46PRKD21.04822865
47NEK91.04487709
48HCK1.01554249
49SYK1.01515989
50MAP3K11.00638203
51GRK61.00626454
52KDR0.99107599
53CSK0.98989943
54RIPK40.98380729
55MAP3K80.97777299
56MATK0.97464465
57NEK20.95010988
58MAPKAPK30.94914718
59PTK60.91920787
60MAP3K30.87597708
61STK40.84405719
62TGFBR10.84390038
63EIF2AK10.83323343
64PAK20.81844930
65TXK0.80288759
66CDC42BPA0.79636124
67IRAK30.78456891
68FGFR40.78268233
69RPS6KB20.77471294
70ARAF0.76831524
71* LCK0.76751135
72BMPR20.76588331
73SIK30.74295163
74MAPKAPK20.73616198
75TEC0.73427838
76CDK60.72269171
77DDR20.71006181
78GRK70.70940021
79LYN0.69224212
80RPS6KL10.67406565
81RPS6KC10.67406565
82ILK0.67242523
83MAPK70.64843308
84JAK20.64796502
85PDPK10.64445066
86ICK0.63146072
87MARK30.61683348
88PDGFRA0.61486930
89PDK10.60287201
90PAK10.59088141
91KSR20.58822028
92MAPK120.57654682
93CDK120.57520984
94RIPK10.56970324
95TLK10.55706244
96BUB10.55541339
97MARK20.55220093
98CAMKK20.54913300
99EPHA30.54865349
100EPHA20.54682776
101MAP2K20.54469388
102TAOK10.52292852
103SIK20.51965057
104RAF10.51896078
105CDK40.51802115
106FGFR30.51536458
107IRAK10.51172421
108HIPK20.50876062
109MAPK110.49950620
110MAPK40.49489348
111CDK190.47521653
112PTK2B0.47239406
113PRKCQ0.46839968
114DYRK30.46698232
115TAOK30.46498298
116ITK0.46275500
117STK30.45948742
118DAPK30.45516819
119RPS6KA20.45136403
120PTK20.44561464
121PRKG20.44141661
122IRAK20.43463329
123FYN0.43159936
124PIK3CG0.42612196
125RPS6KA60.42128281
126LIMK10.41795956
127BCKDK0.41418387
128ABL20.41306804
129DYRK1B0.41223853
130MAP3K50.40690094
131ALK0.38477040
132SIK10.38379017
133EGFR0.36528980
134CLK10.36471533
135FGR0.34924476
136RPS6KA50.34620973

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.59647765
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.28582277
3Antigen processing and presentation_Homo sapiens_hsa046122.01085451
4Osteoclast differentiation_Homo sapiens_hsa043801.97591244
5* Measles_Homo sapiens_hsa051621.90824589
6Shigellosis_Homo sapiens_hsa051311.84450375
7Apoptosis_Homo sapiens_hsa042101.83810047
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.83358939
9B cell receptor signaling pathway_Homo sapiens_hsa046621.81644888
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81154579
11Ribosome_Homo sapiens_hsa030101.79241945
12Malaria_Homo sapiens_hsa051441.77306556
13Primary immunodeficiency_Homo sapiens_hsa053401.76430640
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74905900
15Toxoplasmosis_Homo sapiens_hsa051451.72289257
16Legionellosis_Homo sapiens_hsa051341.66576816
17TNF signaling pathway_Homo sapiens_hsa046681.66009503
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64526763
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60703832
20p53 signaling pathway_Homo sapiens_hsa041151.58762269
21Chronic myeloid leukemia_Homo sapiens_hsa052201.58145290
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53736512
23Herpes simplex infection_Homo sapiens_hsa051681.52253781
24Allograft rejection_Homo sapiens_hsa053301.50416511
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50358483
26Tuberculosis_Homo sapiens_hsa051521.47276177
27Pertussis_Homo sapiens_hsa051331.46705863
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45763831
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45745625
30Small cell lung cancer_Homo sapiens_hsa052221.44216877
31Hematopoietic cell lineage_Homo sapiens_hsa046401.42286644
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41923856
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.38788656
34Influenza A_Homo sapiens_hsa051641.36282553
35Acute myeloid leukemia_Homo sapiens_hsa052211.33221395
36DNA replication_Homo sapiens_hsa030301.32986901
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32874931
38Hepatitis B_Homo sapiens_hsa051611.32627636
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30429395
40Graft-versus-host disease_Homo sapiens_hsa053321.29057805
41Other glycan degradation_Homo sapiens_hsa005111.28623129
42Viral myocarditis_Homo sapiens_hsa054161.26087903
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.23167056
44Viral carcinogenesis_Homo sapiens_hsa052031.22789129
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21856139
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.20793945
47Salmonella infection_Homo sapiens_hsa051321.20660064
48Epstein-Barr virus infection_Homo sapiens_hsa051691.16319804
49Lysosome_Homo sapiens_hsa041421.15090828
50Pancreatic cancer_Homo sapiens_hsa052121.11150702
51Staphylococcus aureus infection_Homo sapiens_hsa051501.06593602
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05842471
53Chemokine signaling pathway_Homo sapiens_hsa040621.05401606
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02676387
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98769486
56HTLV-I infection_Homo sapiens_hsa051660.98415918
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98087987
58Bladder cancer_Homo sapiens_hsa052190.97992464
59Base excision repair_Homo sapiens_hsa034100.97942520
60T cell receptor signaling pathway_Homo sapiens_hsa046600.95690481
61Platelet activation_Homo sapiens_hsa046110.94384287
62Phagosome_Homo sapiens_hsa041450.90657153
63Proteoglycans in cancer_Homo sapiens_hsa052050.90240544
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89083118
65MicroRNAs in cancer_Homo sapiens_hsa052060.88369196
66Focal adhesion_Homo sapiens_hsa045100.87811770
67Amoebiasis_Homo sapiens_hsa051460.86333221
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.86178997
69Proteasome_Homo sapiens_hsa030500.83689059
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83183855
71One carbon pool by folate_Homo sapiens_hsa006700.81753488
72Systemic lupus erythematosus_Homo sapiens_hsa053220.81679194
73Rheumatoid arthritis_Homo sapiens_hsa053230.79663247
74HIF-1 signaling pathway_Homo sapiens_hsa040660.79113794
75Prolactin signaling pathway_Homo sapiens_hsa049170.78796489
76African trypanosomiasis_Homo sapiens_hsa051430.78744362
77Asthma_Homo sapiens_hsa053100.78398105
78Pentose phosphate pathway_Homo sapiens_hsa000300.77027877
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75102325
80Hepatitis C_Homo sapiens_hsa051600.74814241
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73818591
82Cell cycle_Homo sapiens_hsa041100.72032284
83ECM-receptor interaction_Homo sapiens_hsa045120.71988256
84Autoimmune thyroid disease_Homo sapiens_hsa053200.69092536
85VEGF signaling pathway_Homo sapiens_hsa043700.67516413
86Mismatch repair_Homo sapiens_hsa034300.66274259
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65552362
88Non-small cell lung cancer_Homo sapiens_hsa052230.64232271
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63901515
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.61243373
91Galactose metabolism_Homo sapiens_hsa000520.59030203
92Notch signaling pathway_Homo sapiens_hsa043300.58286440
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58283585
94Colorectal cancer_Homo sapiens_hsa052100.57519852
95Endocytosis_Homo sapiens_hsa041440.56065876
96Homologous recombination_Homo sapiens_hsa034400.54987068
97Spliceosome_Homo sapiens_hsa030400.54050835
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52512418
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52249855
100Adherens junction_Homo sapiens_hsa045200.50941577
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.49246357
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.48157508
103Sulfur relay system_Homo sapiens_hsa041220.48109179
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46356830
105Pathways in cancer_Homo sapiens_hsa052000.46266918
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46097510
107Nucleotide excision repair_Homo sapiens_hsa034200.45906616
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45167904
109Prostate cancer_Homo sapiens_hsa052150.45149317
110RNA transport_Homo sapiens_hsa030130.44782568
111Prion diseases_Homo sapiens_hsa050200.44556320
112Type I diabetes mellitus_Homo sapiens_hsa049400.42485244
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42137028
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42039114
115mTOR signaling pathway_Homo sapiens_hsa041500.41335824
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40233002
117Renal cell carcinoma_Homo sapiens_hsa052110.40162767
118Collecting duct acid secretion_Homo sapiens_hsa049660.34244207
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.31973787
120Endometrial cancer_Homo sapiens_hsa052130.30894777
121Fructose and mannose metabolism_Homo sapiens_hsa000510.26709895
122Vibrio cholerae infection_Homo sapiens_hsa051100.24265433
123MAPK signaling pathway_Homo sapiens_hsa040100.21594167
124FoxO signaling pathway_Homo sapiens_hsa040680.20681231

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