DOK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.58952196
2T cell migration (GO:0072678)5.40856801
3positive regulation of gamma-delta T cell activation (GO:0046645)5.37794312
4leukocyte aggregation (GO:0070486)4.83718814
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.78384615
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56499771
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56499771
8regulation of B cell receptor signaling pathway (GO:0050855)4.53498653
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.53264679
10mast cell activation (GO:0045576)4.53141171
11detection of other organism (GO:0098543)4.36979174
12detection of bacterium (GO:0016045)4.33304968
13immunoglobulin mediated immune response (GO:0016064)4.14199351
14negative regulation of cell killing (GO:0031342)4.12651390
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.12651390
16antigen processing and presentation of endogenous antigen (GO:0019883)4.12037961
17positive thymic T cell selection (GO:0045059)4.06674938
18negative T cell selection (GO:0043383)4.03549041
19regulation of gamma-delta T cell differentiation (GO:0045586)4.03026390
20negative regulation of interleukin-12 production (GO:0032695)4.02567148
21negative thymic T cell selection (GO:0045060)4.02055230
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.00658302
23cellular extravasation (GO:0045123)3.95901927
24interferon-gamma production (GO:0032609)3.91894991
25granulocyte activation (GO:0036230)3.90729050
26neutrophil activation involved in immune response (GO:0002283)3.89035536
27respiratory burst (GO:0045730)3.88632255
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.88542050
29macrophage activation involved in immune response (GO:0002281)3.86903333
30positive regulation of mast cell activation (GO:0033005)3.83855271
31regulation of mast cell degranulation (GO:0043304)3.83025623
32regulation of gamma-delta T cell activation (GO:0046643)3.82788706
33negative regulation of leukocyte mediated immunity (GO:0002704)3.77841043
34sequestering of actin monomers (GO:0042989)3.74826608
35mast cell activation involved in immune response (GO:0002279)3.74505514
36mast cell degranulation (GO:0043303)3.74505514
37cellular response to interleukin-15 (GO:0071350)3.67809806
38lymphocyte chemotaxis (GO:0048247)3.61512034
39negative regulation of T cell mediated immunity (GO:0002710)3.57440154
40regulation of B cell differentiation (GO:0045577)3.55442012
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53250608
42cellular response to type I interferon (GO:0071357)3.52605613
43type I interferon signaling pathway (GO:0060337)3.52605613
44response to type I interferon (GO:0034340)3.52038878
45response to interleukin-15 (GO:0070672)3.51781331
46regulation of mast cell activation involved in immune response (GO:0033006)3.50870117
47activated T cell proliferation (GO:0050798)3.45646287
48B cell mediated immunity (GO:0019724)3.44432817
49regulation of tolerance induction (GO:0002643)3.43949612
50detection of external biotic stimulus (GO:0098581)3.43202589
51regulation of mast cell activation (GO:0033003)3.42658527
52lymphocyte migration (GO:0072676)3.41564113
53regulation of isotype switching to IgG isotypes (GO:0048302)3.40239123
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39987952
55leukocyte migration involved in inflammatory response (GO:0002523)3.39887957
56response to peptidoglycan (GO:0032494)3.37140070
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36855871
58myeloid cell activation involved in immune response (GO:0002275)3.34955186
59myeloid dendritic cell activation (GO:0001773)3.34896183
60regulation of regulatory T cell differentiation (GO:0045589)3.31983967
61B cell receptor signaling pathway (GO:0050853)3.31657449
62production of molecular mediator involved in inflammatory response (GO:0002532)3.29848939
63regulation of leukocyte degranulation (GO:0043300)3.29847283
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28704694
65positive regulation of macrophage differentiation (GO:0045651)3.28091381
66response to protozoan (GO:0001562)3.27955913
67regulation of T cell mediated cytotoxicity (GO:0001914)3.26399889
68positive T cell selection (GO:0043368)3.25011144
69negative regulation of phagocytosis (GO:0050765)3.24789879
70positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24076754
71defense response to protozoan (GO:0042832)3.23675511
72pinocytosis (GO:0006907)3.20242669
73positive regulation of antigen processing and presentation (GO:0002579)3.19753609
74thymic T cell selection (GO:0045061)3.18151630
75response to muramyl dipeptide (GO:0032495)3.17852147
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17526553
77positive regulation of mast cell activation involved in immune response (GO:0033008)3.17294866
78positive regulation of mast cell degranulation (GO:0043306)3.17294866
79regulation of alpha-beta T cell proliferation (GO:0046640)3.15679121
80antigen processing and presentation via MHC class Ib (GO:0002475)3.15447629
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.15316940
82negative regulation of innate immune response (GO:0045824)3.15177931
83positive regulation of B cell differentiation (GO:0045579)3.14416713
84positive regulation of interferon-alpha production (GO:0032727)3.13063005
85modulation by symbiont of host defense response (GO:0052031)3.12048457
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.12048457
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.12048457
88positive regulation by organism of defense response of other organism involved in symbiotic interact3.12048457
89modulation by symbiont of host immune response (GO:0052553)3.12048457
90positive regulation by symbiont of host defense response (GO:0052509)3.12048457
91natural killer cell activation (GO:0030101)3.11054078
92microglial cell activation (GO:0001774)3.09773110
93negative regulation of erythrocyte differentiation (GO:0045647)3.09686199
94regulation of T cell receptor signaling pathway (GO:0050856)3.09478419
95leukocyte cell-cell adhesion (GO:0007159)3.09374226
96regulation of leukocyte mediated cytotoxicity (GO:0001910)3.08051040
97interferon-gamma-mediated signaling pathway (GO:0060333)3.06067224
98positive regulation of isotype switching (GO:0045830)3.02620642
99leukocyte degranulation (GO:0043299)3.01588358
100detection of biotic stimulus (GO:0009595)3.01242765
101regulation of interferon-alpha production (GO:0032647)3.00297330
102T cell receptor signaling pathway (GO:0050852)2.98901858
103response to interferon-beta (GO:0035456)2.97197309
104antigen receptor-mediated signaling pathway (GO:0050851)2.97086227
105positive regulation of tolerance induction (GO:0002645)2.95752357
106dendritic cell chemotaxis (GO:0002407)2.95747475
107actin nucleation (GO:0045010)2.94998361
108response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.93602207
109response to host immune response (GO:0052572)2.93602207
110T cell selection (GO:0045058)2.92418057
111T cell costimulation (GO:0031295)2.92407709
112positive regulation of lamellipodium assembly (GO:0010592)2.92204804
113natural killer cell differentiation (GO:0001779)2.91559003
114regulation of interleukin-12 biosynthetic process (GO:0045075)2.90775111
115positive regulation of interleukin-2 production (GO:0032743)2.90176264
116positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.90164782
117cellular response to interferon-beta (GO:0035458)2.89771019
118lymphocyte costimulation (GO:0031294)2.89092497
119regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86750952
120regulation of T cell tolerance induction (GO:0002664)2.85528248
121positive regulation of immunoglobulin mediated immune response (GO:0002891)2.84762544
122positive regulation of B cell mediated immunity (GO:0002714)2.84762544
123positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84285932
124negative regulation of alpha-beta T cell activation (GO:0046636)2.83855632
125macrophage activation (GO:0042116)2.83841943
126regulation of natural killer cell mediated immunity (GO:0002715)2.83731212
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83731212
128regulation of response to interferon-gamma (GO:0060330)2.83548295
129regulation of antigen processing and presentation (GO:0002577)2.82509522
130positive regulation of granulocyte differentiation (GO:0030854)2.81155545
131regulation of interferon-beta biosynthetic process (GO:0045357)2.79832756
132regulation of cell killing (GO:0031341)2.79121898
133myeloid dendritic cell differentiation (GO:0043011)2.78850541
134regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78794485
135positive regulation of natural killer cell mediated immunity (GO:0002717)2.78687151
136cellular defense response (GO:0006968)2.78536043
137positive regulation of interferon-gamma production (GO:0032729)2.77955022
138positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.75833974
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.72589019
140neutrophil activation (GO:0042119)2.70677000
141tolerance induction (GO:0002507)2.70140802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.08123778
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.55634623
3E2F7_22180533_ChIP-Seq_HELA_Human4.51269313
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00181277
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.93160072
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.91257898
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.79989011
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46133526
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18237458
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02170372
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.92460668
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88045950
13* IRF8_27001747_Chip-Seq_BMDM_Mouse2.86255067
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74925246
15* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67500813
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67317954
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.65046145
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50302318
19SPI1_23547873_ChIP-Seq_NB4_Human2.49871048
20SCL_19346495_ChIP-Seq_HPC-7_Human2.49801556
21* MYB_26560356_Chip-Seq_TH2_Human2.34249794
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31017716
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22902742
24MAF_26560356_Chip-Seq_TH1_Human2.22229531
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.21177950
26* RUNX_20019798_ChIP-Seq_JUKART_Human2.17913630
27MYC_22102868_ChIP-Seq_BL_Human2.14222859
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10111667
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08211228
30* VDR_21846776_ChIP-Seq_THP-1_Human2.07596519
31* RUNX1_22412390_ChIP-Seq_EML_Mouse2.07051407
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.97043442
33MYB_26560356_Chip-Seq_TH1_Human1.96621012
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90814857
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.88179338
36* UTX_26944678_Chip-Seq_JUKART_Human1.87656232
37* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.83749250
38* VDR_24763502_ChIP-Seq_THP-1_Human1.83637439
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78181510
40* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74815251
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73066450
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.64026314
43VDR_24787735_ChIP-Seq_THP-1_Human1.57206973
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54478959
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54048524
46Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51759927
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51399054
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49732080
49SPI1_23127762_ChIP-Seq_K562_Human1.48138614
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47378115
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46485892
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.44148340
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43841138
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.41629703
55MAF_26560356_Chip-Seq_TH2_Human1.40312041
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40061757
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39350429
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37312178
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37281148
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35547611
61GATA3_27048872_Chip-Seq_THYMUS_Human1.33844335
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32845361
63LXR_22292898_ChIP-Seq_THP-1_Human1.32632783
64* PU_27001747_Chip-Seq_BMDM_Mouse1.31902747
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.31181314
66* GATA1_19941826_ChIP-Seq_K562_Human1.31162087
67BCL6_27268052_Chip-Seq_Bcells_Human1.26960721
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25361936
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23347282
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23295232
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22870447
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22230616
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.20512056
74* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18411161
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18173972
76* VDR_23849224_ChIP-Seq_CD4+_Human1.18015842
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16793174
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15603210
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15532890
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14237632
81* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13756087
82BCOR_27268052_Chip-Seq_Bcells_Human1.10871061
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10775544
84GATA3_26560356_Chip-Seq_TH2_Human1.10717745
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09993800
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08787794
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08256807
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.06774080
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05110971
90FOXP3_21729870_ChIP-Seq_TREG_Human1.03574616
91* GATA2_19941826_ChIP-Seq_K562_Human1.02301344
92* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00497813
93GABP_17652178_ChIP-ChIP_JURKAT_Human0.99884921
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99013433
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.97780265
96* ELK3_25401928_ChIP-Seq_HUVEC_Human0.97742170
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96912053
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.96485335
99GATA1_22025678_ChIP-Seq_K562_Human0.96375905
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96276373
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95483242
102* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95442959
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.94653721
104* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92495921
105NCOR1_26117541_ChIP-Seq_K562_Human0.92101052
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90795335
107EST1_17652178_ChIP-ChIP_JURKAT_Human0.88705223
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88291882
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87631548
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87631504
111TFEB_21752829_ChIP-Seq_HELA_Human0.86526441
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86286670
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85637846
114ELK1_19687146_ChIP-ChIP_HELA_Human0.85242762
115* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83634386
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82757661
117STAT1_20625510_ChIP-Seq_HELA_Human0.82726695
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82143151
119SPI1_20517297_ChIP-Seq_HL60_Human0.81601584
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81382650
121* GATA1_19941827_ChIP-Seq_MEL_Mouse0.80742949
122ETS1_20019798_ChIP-Seq_JURKAT_Human0.78785612
123KDM2B_26808549_Chip-Seq_DND41_Human0.77163384
124CIITA_25753668_ChIP-Seq_RAJI_Human0.75498440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.40151609
2MP0005671_abnormal_response_to4.04740062
3MP0009785_altered_susceptibility_to3.88710482
4MP0003436_decreased_susceptibility_to3.46831026
5MP0006082_CNS_inflammation3.44691792
6MP0003763_abnormal_thymus_physiology3.20122484
7MP0005000_abnormal_immune_tolerance3.13874445
8MP0002148_abnormal_hypersensitivity_rea3.11673536
9MP0005025_abnormal_response_to3.06864499
10MP0000685_abnormal_immune_system3.05123163
11MP0003724_increased_susceptibility_to2.87412667
12MP0001800_abnormal_humoral_immune2.87247776
13MP0002419_abnormal_innate_immunity2.85129073
14MP0002452_abnormal_antigen_presenting2.74478468
15MP0002723_abnormal_immune_serum2.74083103
16MP0001790_abnormal_immune_system2.69674138
17MP0005387_immune_system_phenotype2.69674138
18* MP0002420_abnormal_adaptive_immunity2.65293771
19* MP0001819_abnormal_immune_cell2.63826115
20MP0002405_respiratory_system_inflammati2.44816772
21MP0009333_abnormal_splenocyte_physiolog2.39077519
22MP0005464_abnormal_platelet_physiology2.39018369
23MP0002398_abnormal_bone_marrow2.32935615
24MP0000716_abnormal_immune_system2.12755594
25MP0005058_abnormal_lysosome_morphology2.10632636
26MP0003303_peritoneal_inflammation2.09694727
27MP0002166_altered_tumor_susceptibility2.08755251
28MP0002396_abnormal_hematopoietic_system2.07338134
29MP0010155_abnormal_intestine_physiology2.02596876
30MP0002006_tumorigenesis1.99391132
31MP0000689_abnormal_spleen_morphology1.92112669
32* MP0002722_abnormal_immune_system1.88893507
33MP0001845_abnormal_inflammatory_respons1.85873982
34MP0002429_abnormal_blood_cell1.79305199
35MP0001853_heart_inflammation1.67515462
36MP0004947_skin_inflammation1.67040532
37MP0001533_abnormal_skeleton_physiology1.66855004
38MP0004510_myositis1.66752005
39MP0003448_altered_tumor_morphology1.65845911
40MP0008469_abnormal_protein_level1.58593679
41MP0002132_abnormal_respiratory_system1.56807257
42MP0000858_altered_metastatic_potential1.53966588
43* MP0000703_abnormal_thymus_morphology1.53952950
44MP0004808_abnormal_hematopoietic_stem1.53804220
45MP0001545_abnormal_hematopoietic_system1.52756836
46MP0005397_hematopoietic_system_phenotyp1.52756836
47MP0000490_abnormal_crypts_of1.50487368
48MP0001873_stomach_inflammation1.47600937
49MP0000343_altered_response_to1.45251930
50MP0000465_gastrointestinal_hemorrhage1.44755111
51MP0003866_abnormal_defecation1.37833510
52MP0002933_joint_inflammation1.34495297
53MP0005174_abnormal_tail_pigmentation1.31991434
54MP0005310_abnormal_salivary_gland1.26163278
55MP0003172_abnormal_lysosome_physiology1.18883081
56MP0009278_abnormal_bone_marrow1.18081895
57MP0009764_decreased_sensitivity_to1.16744873
58MP0008004_abnormal_stomach_pH1.14104023
59MP0003300_gastrointestinal_ulcer1.13895876
60MP0003183_abnormal_peptide_metabolism1.11700600
61MP0005166_decreased_susceptibility_to1.09283136
62MP0008260_abnormal_autophagy1.08414530
63MP0003828_pulmonary_edema1.08369079
64MP0003191_abnormal_cellular_cholesterol1.06667452
65* MP0002019_abnormal_tumor_incidence1.01877610
66MP0002998_abnormal_bone_remodeling0.99716824
67MP0001851_eye_inflammation0.99508507
68MP0004883_abnormal_blood_vessel0.99277492
69MP0009763_increased_sensitivity_to0.98985239
70MP0010307_abnormal_tumor_latency0.98755789
71MP0008007_abnormal_cellular_replicative0.94209536
72MP0003045_fibrosis0.93828882
73MP0005075_abnormal_melanosome_morpholog0.92653794
74MP0009840_abnormal_foam_cell0.89989769
75MP0000015_abnormal_ear_pigmentation0.87407217
76MP0003075_altered_response_to0.87168512
77MP0003693_abnormal_embryo_hatching0.86661564
78MP0003077_abnormal_cell_cycle0.86396459
79MP0003806_abnormal_nucleotide_metabolis0.82639167
80MP0004381_abnormal_hair_follicle0.81208282
81MP0008057_abnormal_DNA_replication0.78484512
82MP0004130_abnormal_muscle_cell0.77601200
83MP0010094_abnormal_chromosome_stability0.76458462
84MP0010352_gastrointestinal_tract_polyps0.76056447
85MP0005390_skeleton_phenotype0.73506793
86MP0005164_abnormal_response_to0.70994257
87MP0005451_abnormal_body_composition0.69360222
88MP0002138_abnormal_hepatobiliary_system0.69010639
89MP0003186_abnormal_redox_activity0.65582254
90MP0002095_abnormal_skin_pigmentation0.65574729
91MP0001986_abnormal_taste_sensitivity0.64783866
92MP0008058_abnormal_DNA_repair0.64449999
93MP0000604_amyloidosis0.63313680
94MP0005076_abnormal_cell_differentiation0.61495967
95MP0003795_abnormal_bone_structure0.60411629
96MP0008874_decreased_physiological_sensi0.59304273
97MP0005083_abnormal_biliary_tract0.58940559
98MP0002009_preneoplasia0.58271040
99MP0003656_abnormal_erythrocyte_physiolo0.57845537
100MP0000371_diluted_coat_color0.57317091
101MP0003111_abnormal_nucleus_morphology0.57040520
102MP0000313_abnormal_cell_death0.56360978
103MP0001663_abnormal_digestive_system0.56245863
104MP0002277_abnormal_respiratory_mucosa0.55556287
105MP0002136_abnormal_kidney_physiology0.55165171
106MP0005023_abnormal_wound_healing0.55118509
107MP0003566_abnormal_cell_adhesion0.54844116
108MP0008873_increased_physiological_sensi0.54617729
109MP0000249_abnormal_blood_vessel0.54301125
110MP0005381_digestive/alimentary_phenotyp0.53359733
111MP0004957_abnormal_blastocyst_morpholog0.53064355
112MP0000920_abnormal_myelination0.51928609
113MP0005319_abnormal_enzyme/_coenzyme0.49832725
114MP0002693_abnormal_pancreas_physiology0.49184471
115MP0000609_abnormal_liver_physiology0.48912883
116MP0003690_abnormal_glial_cell0.48719972
117MP0003638_abnormal_response/metabolism_0.48216228
118MP0005167_abnormal_blood-brain_barrier0.46795696
119MP0009765_abnormal_xenobiotic_induced0.45746329
120MP0005388_respiratory_system_phenotype0.43767130
121MP0002133_abnormal_respiratory_system0.43767130

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.34759035
2Eczematoid dermatitis (HP:0000976)6.17211109
3Recurrent bacterial skin infections (HP:0005406)5.40657720
4Myositis (HP:0100614)4.70517554
5Elevated erythrocyte sedimentation rate (HP:0003565)4.62088067
6Recurrent fungal infections (HP:0002841)4.38250775
7T lymphocytopenia (HP:0005403)4.37091691
8Recurrent gram-negative bacterial infections (HP:0005420)4.33266877
9Vacuolated lymphocytes (HP:0001922)4.30193865
10Abnormality of T cell number (HP:0011839)4.23532286
11Systemic lupus erythematosus (HP:0002725)4.03087817
12Mediastinal lymphadenopathy (HP:0100721)3.95927296
13Recurrent skin infections (HP:0001581)3.94729750
14Pustule (HP:0200039)3.92922331
15Stomatitis (HP:0010280)3.87519305
16Abnormality of macrophages (HP:0004311)3.83783369
17Obstructive lung disease (HP:0006536)3.80102047
18Chronic obstructive pulmonary disease (HP:0006510)3.80102047
19Orchitis (HP:0100796)3.78864199
20IgM deficiency (HP:0002850)3.77023940
21Chronic mucocutaneous candidiasis (HP:0002728)3.75390594
22Recurrent cutaneous fungal infections (HP:0011370)3.75390594
23Optic neuritis (HP:0100653)3.72586455
24Retrobulbar optic neuritis (HP:0100654)3.72586455
25Recurrent viral infections (HP:0004429)3.70705566
26Abnormality of T cells (HP:0002843)3.63236052
27Petechiae (HP:0000967)3.48292500
28Severe combined immunodeficiency (HP:0004430)3.40379978
29Chronic otitis media (HP:0000389)3.38894078
30Increased cerebral lipofuscin (HP:0011813)3.33006406
31Increased neuronal autofluorescent lipopigment (HP:0002074)3.31196722
32Gingivitis (HP:0000230)3.25382253
33Meningitis (HP:0001287)3.23595556
34Combined immunodeficiency (HP:0005387)3.20736065
35Abnormality of liposaccharide metabolism (HP:0010968)3.17037043
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.17037043
37Abnormality of glycolipid metabolism (HP:0010969)3.17037043
38Recurrent bronchitis (HP:0002837)3.16292256
39Increased IgM level (HP:0003496)3.08042529
40Panhypogammaglobulinemia (HP:0003139)3.07056733
41Vasculitis (HP:0002633)3.04712450
42Nasal polyposis (HP:0100582)3.03005059
43IgG deficiency (HP:0004315)3.01137288
44Cellulitis (HP:0100658)2.93903777
45Abnormality of T cell physiology (HP:0011840)2.87890538
46Leukocytosis (HP:0001974)2.87521855
47Spontaneous hematomas (HP:0007420)2.85666240
48Chest pain (HP:0100749)2.83233009
49Abnormality of the prostate (HP:0008775)2.82307310
50Prolonged bleeding time (HP:0003010)2.81592786
51Thyroiditis (HP:0100646)2.80006201
52Thrombocytosis (HP:0001894)2.78562227
53Abnormal platelet volume (HP:0011876)2.77377626
54Pulmonary infiltrates (HP:0002113)2.75105502
55Abnormality of the nasal mucosa (HP:0000433)2.74148781
56Prostate neoplasm (HP:0100787)2.70382559
57Autoimmune thrombocytopenia (HP:0001973)2.68192214
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.64829783
59Encephalitis (HP:0002383)2.63426621
60Lymphopenia (HP:0001888)2.63346719
61Epistaxis (HP:0000421)2.61409322
62Agnosia (HP:0010524)2.58214376
63Basal ganglia calcification (HP:0002135)2.57229797
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.56539162
65Hemoptysis (HP:0002105)2.52650218
66Episodic fever (HP:0001954)2.51808125
67Urticaria (HP:0001025)2.50307562
68Keratoconjunctivitis sicca (HP:0001097)2.48568335
69Increased serum ferritin (HP:0003281)2.47956202
70Pulmonary embolism (HP:0002204)2.46919924
71Hypergammaglobulinemia (HP:0010702)2.46459070
72Arterial thrombosis (HP:0004420)2.46064043
73Abnormality of eosinophils (HP:0001879)2.45513630
74Gingival bleeding (HP:0000225)2.43051899
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42383680
76Hypochromic anemia (HP:0001931)2.42078738
77Inflammation of the large intestine (HP:0002037)2.39983138
78Glomerulonephritis (HP:0000099)2.35823707
79Gastrointestinal infarctions (HP:0005244)2.34787107
80Joint swelling (HP:0001386)2.34718951
81Loss of speech (HP:0002371)2.32039961
82Gastrointestinal inflammation (HP:0004386)2.30730291
83Menorrhagia (HP:0000132)2.29359493
84Dysostosis multiplex (HP:0000943)2.27684971
85Chronic diarrhea (HP:0002028)2.27335830
86Hypoplasia of the thymus (HP:0000778)2.26262601
87Anorexia (HP:0002039)2.25637631
88Colitis (HP:0002583)2.25249808
89Purpura (HP:0000979)2.24751179
90Autoimmune hemolytic anemia (HP:0001890)2.23621457
91Keratoconjunctivitis (HP:0001096)2.23519594
92Abnormality of iron homeostasis (HP:0011031)2.22763578
93Agammaglobulinemia (HP:0004432)2.20614885
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20239669
95Periodontitis (HP:0000704)2.20090903
96Reduced antithrombin III activity (HP:0001976)2.17492585
97Lymphoma (HP:0002665)2.13673345
98Amyloidosis (HP:0011034)2.12958500
99Hypochromic microcytic anemia (HP:0004840)2.12738372
100Eosinophilia (HP:0001880)2.10554255
101Increased mean platelet volume (HP:0011877)2.09374918
102Increased IgE level (HP:0003212)2.08382674
103Recurrent pneumonia (HP:0006532)2.04261028
104Interstitial pulmonary disease (HP:0006530)2.01484366
105Reticulocytopenia (HP:0001896)2.01400544
106Abnormality of the pleura (HP:0002103)2.00882536
107Albinism (HP:0001022)2.00657087
108Premature loss of primary teeth (HP:0006323)2.00372011
109Hematochezia (HP:0002573)1.99621575
110Microcytic anemia (HP:0001935)1.99366511
111Osteomyelitis (HP:0002754)1.99181560
112Glomerulopathy (HP:0100820)1.98056847
113Thoracic kyphosis (HP:0002942)1.95923862
114Gangrene (HP:0100758)1.94477401
115Granulocytopenia (HP:0001913)1.94143482
116Skin ulcer (HP:0200042)1.93000551
117Cheilitis (HP:0100825)1.92851342
118IgA deficiency (HP:0002720)1.90967556
119Hepatosplenomegaly (HP:0001433)1.90939486
120Polyneuropathy (HP:0001271)1.90114420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.54329498
2MAP4K14.44185593
3BLK3.16288082
4ZAP703.15860739
5IRAK43.06121436
6NME22.83316476
7IKBKE2.75173549
8TBK12.56444621
9TYK22.50420545
10KIT2.49233070
11JAK32.46558223
12MAP3K142.38082589
13TEC2.22840200
14PRPF4B2.10427061
15TESK22.06379862
16PIM21.96960581
17MAP3K131.94107968
18KDR1.88841854
19ITK1.84377354
20* BTK1.83313268
21LCK1.81044901
22SYK1.79391868
23STK101.76614366
24BUB11.76455095
25RIPK41.64798053
26FGR1.63613555
27IKBKB1.62410632
28JAK11.61626315
29CSF1R1.58494659
30CSK1.57909576
31SIK31.44453439
32MAP3K121.40297300
33MAP3K31.34317066
34TAOK31.27557073
35TAOK11.26903710
36* HCK1.25390639
37* LYN1.23648988
38FGFR41.21630158
39IRAK31.19408331
40FES1.17645345
41LRRK21.10437660
42ERN11.09952795
43BMPR21.09862445
44PIM11.07705249
45GRK61.07173528
46RPS6KA41.04900426
47NLK1.00347798
48FLT30.99598845
49CAMKK20.98503430
50CLK10.97695010
51NEK90.96825011
52TGFBR20.96335559
53MST40.92586820
54PDK10.91796688
55MAP3K10.90142440
56MAP2K30.85433097
57ADRBK20.85226674
58FGFR30.84867721
59TAOK20.83898513
60JAK20.77833358
61STK40.75300967
62MAPK120.74819922
63TNK20.74471316
64TESK10.72041397
65YES10.70728794
66ACVR1B0.69107909
67PKN20.67233911
68PTK2B0.67110772
69EPHB10.66652863
70MAP3K110.66298599
71CHUK0.65838036
72MAP3K100.65807028
73PDPK10.65663261
74MAPK70.65307026
75PRKD20.64109196
76KSR20.63509293
77MARK20.62501974
78GRK70.62250015
79BMX0.62055696
80CAMKK10.58681775
81MARK30.57380015
82EEF2K0.55274323
83PIK3CG0.55231151
84MAP3K70.54818197
85MAP2K20.52240450
86CDK40.51632992
87PBK0.51098280
88CDC42BPA0.50678851
89TLK10.50424424
90PTK60.50331480
91PRKCQ0.50225035
92DAPK10.49577940
93TRIB30.48319460
94RPS6KA60.48103225
95PRKCD0.47440737
96TGFBR10.47282240
97EIF2AK20.46483094
98ABL10.45588687
99CDC70.43312378
100HIPK20.43233736
101STK240.42854878
102DAPK30.42826346
103CDK60.41793156
104WEE10.40890318
105ILK0.40257664
106SCYL20.40176698
107EIF2AK30.38868941
108DYRK1B0.38085092
109RPS6KC10.37565591
110RPS6KL10.37565591
111FYN0.37188284
112RET0.36886864
113MAP2K60.36762055
114IRAK10.36646734
115ABL20.36323055
116RPS6KA50.35057694
117MAP3K50.34902865
118MOS0.34479265
119PAK40.34401251
120MAPKAPK20.33654791
121NEK20.33392300
122MAPK110.32455670
123EGFR0.31665590
124ATR0.31411582
125CDK70.31171960
126IRAK20.31110990
127MAPK40.30929349
128SIK10.30732562
129MATK0.30177207
130MUSK0.29709509
131IGF1R0.27320787
132SIK20.26932997
133VRK10.26854646
134TTN0.26426522
135INSR0.26301720
136PRKD10.25838731
137DAPK20.23481000
138EPHA30.22843960
139ARAF0.22835533

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.46636602
2Primary immunodeficiency_Homo sapiens_hsa053403.37589692
3Leishmaniasis_Homo sapiens_hsa051402.92619014
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.76916898
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63576861
6Staphylococcus aureus infection_Homo sapiens_hsa051502.63363996
7Measles_Homo sapiens_hsa051622.52916377
8Allograft rejection_Homo sapiens_hsa053302.46320547
9Antigen processing and presentation_Homo sapiens_hsa046122.45670121
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.37279568
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33042611
12Hematopoietic cell lineage_Homo sapiens_hsa046402.10042551
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.07852657
14Osteoclast differentiation_Homo sapiens_hsa043802.04428758
15Legionellosis_Homo sapiens_hsa051342.01412649
16DNA replication_Homo sapiens_hsa030301.96634369
17T cell receptor signaling pathway_Homo sapiens_hsa046601.91144624
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88726743
19Pertussis_Homo sapiens_hsa051331.86846501
20Malaria_Homo sapiens_hsa051441.69616439
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68916210
22B cell receptor signaling pathway_Homo sapiens_hsa046621.67581576
23Herpes simplex infection_Homo sapiens_hsa051681.65190610
24Tuberculosis_Homo sapiens_hsa051521.58615176
25Other glycan degradation_Homo sapiens_hsa005111.52977712
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47252642
27Viral myocarditis_Homo sapiens_hsa054161.45269844
28Mismatch repair_Homo sapiens_hsa034301.43939859
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.42602317
30Salmonella infection_Homo sapiens_hsa051321.42307407
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42145582
32Asthma_Homo sapiens_hsa053101.42079238
33Ribosome_Homo sapiens_hsa030101.41955077
34Shigellosis_Homo sapiens_hsa051311.37625112
35Influenza A_Homo sapiens_hsa051641.36605083
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32893276
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31818980
38Toxoplasmosis_Homo sapiens_hsa051451.28540806
39Autoimmune thyroid disease_Homo sapiens_hsa053201.27773097
40Lysosome_Homo sapiens_hsa041421.27298230
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24671975
42Proteasome_Homo sapiens_hsa030501.24293804
43Chemokine signaling pathway_Homo sapiens_hsa040621.21413097
44Base excision repair_Homo sapiens_hsa034101.19642930
45Apoptosis_Homo sapiens_hsa042101.18227473
46Rheumatoid arthritis_Homo sapiens_hsa053231.17127028
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.16804591
48Type I diabetes mellitus_Homo sapiens_hsa049401.15512579
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.14770548
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13830203
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08978795
52Hepatitis B_Homo sapiens_hsa051611.04745872
53Homologous recombination_Homo sapiens_hsa034401.00687696
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98867730
55TNF signaling pathway_Homo sapiens_hsa046680.96625542
56Phagosome_Homo sapiens_hsa041450.95627085
57Pentose phosphate pathway_Homo sapiens_hsa000300.91758034
58Platelet activation_Homo sapiens_hsa046110.89027728
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89014624
60Acute myeloid leukemia_Homo sapiens_hsa052210.85534810
61Non-small cell lung cancer_Homo sapiens_hsa052230.84633754
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80840580
63Nucleotide excision repair_Homo sapiens_hsa034200.73701880
64Spliceosome_Homo sapiens_hsa030400.73492353
65Caffeine metabolism_Homo sapiens_hsa002320.73251589
66Epstein-Barr virus infection_Homo sapiens_hsa051690.72123722
67Non-homologous end-joining_Homo sapiens_hsa034500.71600992
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66817972
69Pancreatic cancer_Homo sapiens_hsa052120.65397088
70Hepatitis C_Homo sapiens_hsa051600.63635229
71African trypanosomiasis_Homo sapiens_hsa051430.62481275
72HTLV-I infection_Homo sapiens_hsa051660.62210827
73Viral carcinogenesis_Homo sapiens_hsa052030.60685613
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.59929868
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58469726
76Pyrimidine metabolism_Homo sapiens_hsa002400.58020184
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.54336249
78Complement and coagulation cascades_Homo sapiens_hsa046100.54060875
79Collecting duct acid secretion_Homo sapiens_hsa049660.53594428
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.52498855
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51860296
82p53 signaling pathway_Homo sapiens_hsa041150.51468333
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50271007
84Renal cell carcinoma_Homo sapiens_hsa052110.50235410
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49311523
86Chronic myeloid leukemia_Homo sapiens_hsa052200.47620502
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45710938
88One carbon pool by folate_Homo sapiens_hsa006700.45632146
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43539259
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.42999228
91Choline metabolism in cancer_Homo sapiens_hsa052310.40765049
92VEGF signaling pathway_Homo sapiens_hsa043700.39954157
93Systemic lupus erythematosus_Homo sapiens_hsa053220.39309689
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37924892
95MAPK signaling pathway_Homo sapiens_hsa040100.37862036
96Cell cycle_Homo sapiens_hsa041100.37319283
97Amoebiasis_Homo sapiens_hsa051460.37113450
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36766834
99Colorectal cancer_Homo sapiens_hsa052100.36542780
100FoxO signaling pathway_Homo sapiens_hsa040680.35864840
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35651829
102Notch signaling pathway_Homo sapiens_hsa043300.35259389
103Endocytosis_Homo sapiens_hsa041440.35130797
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34187784
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34136834
106Arachidonic acid metabolism_Homo sapiens_hsa005900.33602046
107RNA degradation_Homo sapiens_hsa030180.32717214
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32404933
109GnRH signaling pathway_Homo sapiens_hsa049120.30864195
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30702352
111Fanconi anemia pathway_Homo sapiens_hsa034600.30249301
112Rap1 signaling pathway_Homo sapiens_hsa040150.29863795
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.29160191
114HIF-1 signaling pathway_Homo sapiens_hsa040660.28621047
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27566274
116Regulation of autophagy_Homo sapiens_hsa041400.27382565
117RNA polymerase_Homo sapiens_hsa030200.27348575
118Insulin resistance_Homo sapiens_hsa049310.26940331
119Inositol phosphate metabolism_Homo sapiens_hsa005620.24949522
120Endometrial cancer_Homo sapiens_hsa052130.24332747
121Small cell lung cancer_Homo sapiens_hsa052220.23793366
122Prolactin signaling pathway_Homo sapiens_hsa049170.22929309
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22533180
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.21142279
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20523043
126Galactose metabolism_Homo sapiens_hsa000520.20372420

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